CN105943720A - Traditional Chinese medicinal preparation for treating anemia as well as preparation method and application of traditional Chinese medicinal preparation - Google Patents
Traditional Chinese medicinal preparation for treating anemia as well as preparation method and application of traditional Chinese medicinal preparation Download PDFInfo
- Publication number
- CN105943720A CN105943720A CN201610319015.3A CN201610319015A CN105943720A CN 105943720 A CN105943720 A CN 105943720A CN 201610319015 A CN201610319015 A CN 201610319015A CN 105943720 A CN105943720 A CN 105943720A
- Authority
- CN
- China
- Prior art keywords
- herba
- chinese medicine
- traditional chinese
- chinese medicinal
- medicine preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 96
- 208000007502 anemia Diseases 0.000 title claims abstract description 40
- 241000628997 Flos Species 0.000 claims abstract description 29
- 239000003814 drug Substances 0.000 claims description 98
- 241001643642 Viticis Species 0.000 claims description 29
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 28
- 239000000706 filtrate Substances 0.000 claims description 12
- 239000012467 final product Substances 0.000 claims description 11
- 239000002671 adjuvant Substances 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 5
- 238000007493 shaping process Methods 0.000 claims description 5
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 4
- 230000000694 effects Effects 0.000 abstract description 18
- 208000024891 symptom Diseases 0.000 abstract description 12
- 230000006870 function Effects 0.000 abstract description 9
- 210000004369 blood Anatomy 0.000 abstract description 5
- 239000008280 blood Substances 0.000 abstract description 5
- 210000004185 liver Anatomy 0.000 abstract description 5
- 230000001737 promoting effect Effects 0.000 abstract description 5
- 231100000331 toxic Toxicity 0.000 abstract description 5
- 230000002588 toxic effect Effects 0.000 abstract description 5
- 238000004519 manufacturing process Methods 0.000 abstract description 3
- 210000000952 spleen Anatomy 0.000 abstract description 3
- 235000003261 Artemisia vulgaris Nutrition 0.000 abstract description 2
- 210000001124 body fluid Anatomy 0.000 abstract description 2
- 239000010839 body fluid Substances 0.000 abstract description 2
- 235000013399 edible fruits Nutrition 0.000 abstract description 2
- 210000003734 kidney Anatomy 0.000 abstract description 2
- 230000001502 supplementing effect Effects 0.000 abstract description 2
- 235000009051 Ambrosia paniculata var. peruviana Nutrition 0.000 abstract 1
- 235000003097 Artemisia absinthium Nutrition 0.000 abstract 1
- 240000001851 Artemisia dracunculus Species 0.000 abstract 1
- 235000017731 Artemisia dracunculus ssp. dracunculus Nutrition 0.000 abstract 1
- 241001093760 Sapindaceae Species 0.000 abstract 1
- 235000018324 Shepherdia canadensis Nutrition 0.000 abstract 1
- 244000248021 Vitex negundo Species 0.000 abstract 1
- 235000013427 Vitex negundo var incisa Nutrition 0.000 abstract 1
- 235000014961 Vitex negundo var negundo Nutrition 0.000 abstract 1
- 241001251949 Xanthium sibiricum Species 0.000 abstract 1
- 239000001138 artemisia absinthium Substances 0.000 abstract 1
- 235000014956 negundo chastetree Nutrition 0.000 abstract 1
- 210000002784 stomach Anatomy 0.000 abstract 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 abstract 1
- 229940079593 drug Drugs 0.000 description 28
- 239000000203 mixture Substances 0.000 description 20
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 18
- 239000008187 granular material Substances 0.000 description 11
- 239000004375 Dextrin Substances 0.000 description 8
- 229920001353 Dextrin Polymers 0.000 description 8
- 235000019425 dextrin Nutrition 0.000 description 8
- 239000000796 flavoring agent Substances 0.000 description 8
- 229930006000 Sucrose Natural products 0.000 description 7
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 7
- 235000019634 flavors Nutrition 0.000 description 7
- 238000004806 packaging method and process Methods 0.000 description 7
- 208000006673 asthma Diseases 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 6
- 206010011224 Cough Diseases 0.000 description 5
- 229920002472 Starch Polymers 0.000 description 5
- 238000009835 boiling Methods 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- 239000006187 pill Substances 0.000 description 5
- 239000008107 starch Substances 0.000 description 5
- 235000019698 starch Nutrition 0.000 description 5
- 230000001225 therapeutic effect Effects 0.000 description 5
- 241000196324 Embryophyta Species 0.000 description 4
- 244000029684 Vitex negundo var. negundo Species 0.000 description 4
- 239000002775 capsule Substances 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 244000045947 parasite Species 0.000 description 4
- 244000025254 Cannabis sativa Species 0.000 description 3
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 3
- 206010040943 Skin Ulcer Diseases 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 235000009508 confectionery Nutrition 0.000 description 3
- 239000003085 diluting agent Substances 0.000 description 3
- 208000002173 dizziness Diseases 0.000 description 3
- -1 fluidizer Substances 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 235000019359 magnesium stearate Nutrition 0.000 description 3
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 3
- 239000008108 microcrystalline cellulose Substances 0.000 description 3
- 229940016286 microcrystalline cellulose Drugs 0.000 description 3
- 231100000614 poison Toxicity 0.000 description 3
- 231100000019 skin ulcer Toxicity 0.000 description 3
- 230000008961 swelling Effects 0.000 description 3
- 239000003826 tablet Substances 0.000 description 3
- 208000008203 tachypnea Diseases 0.000 description 3
- 206010043089 tachypnoea Diseases 0.000 description 3
- 208000006820 Arthralgia Diseases 0.000 description 2
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 2
- 102000001554 Hemoglobins Human genes 0.000 description 2
- 108010054147 Hemoglobins Proteins 0.000 description 2
- 239000009636 Huang Qi Substances 0.000 description 2
- 206010062717 Increased upper airway secretion Diseases 0.000 description 2
- 208000015817 Infant Nutrition disease Diseases 0.000 description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- 206010068319 Oropharyngeal pain Diseases 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- 201000005702 Pertussis Diseases 0.000 description 2
- 201000007100 Pharyngitis Diseases 0.000 description 2
- 241001619461 Poria <basidiomycete fungus> Species 0.000 description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 description 2
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 208000001848 dysentery Diseases 0.000 description 2
- 201000006549 dyspepsia Diseases 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000004438 eyesight Effects 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- 231100000957 no side effect Toxicity 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 208000026435 phlegm Diseases 0.000 description 2
- 230000007096 poisonous effect Effects 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 2
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- 230000035922 thirst Effects 0.000 description 2
- DCXXMTOCNZCJGO-UHFFFAOYSA-N tristearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 description 2
- 206010000087 Abdominal pain upper Diseases 0.000 description 1
- 235000003826 Artemisia Nutrition 0.000 description 1
- 235000007516 Chrysanthemum Nutrition 0.000 description 1
- 235000008495 Chrysanthemum leucanthemum Nutrition 0.000 description 1
- 244000192528 Chrysanthemum parthenium Species 0.000 description 1
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 description 1
- 244000189548 Chrysanthemum x morifolium Species 0.000 description 1
- 241000756943 Codonopsis Species 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 206010013954 Dysphoria Diseases 0.000 description 1
- 206010015958 Eye pain Diseases 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 206010017553 Furuncle Diseases 0.000 description 1
- 206010019909 Hernia Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- 206010024229 Leprosy Diseases 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 208000019695 Migraine disease Diseases 0.000 description 1
- 229920000881 Modified starch Polymers 0.000 description 1
- 206010062575 Muscle contracture Diseases 0.000 description 1
- 241000475481 Nebula Species 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 244000131316 Panax pseudoginseng Species 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 208000001431 Psychomotor Agitation Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 208000004680 Rectal Fistula Diseases 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 241000130764 Tinea Species 0.000 description 1
- 208000002474 Tinea Diseases 0.000 description 1
- 208000009205 Tinnitus Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 241001073567 Verbenaceae Species 0.000 description 1
- 241000746966 Zizania Species 0.000 description 1
- 235000002636 Zizania aquatica Nutrition 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000000783 alginic acid Substances 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 229960001126 alginic acid Drugs 0.000 description 1
- 150000004781 alginic acids Chemical class 0.000 description 1
- 206010002156 anal fistula Diseases 0.000 description 1
- 244000030166 artemisia Species 0.000 description 1
- 235000009052 artemisia Nutrition 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 206010006451 bronchitis Diseases 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
- 235000013539 calcium stearate Nutrition 0.000 description 1
- 239000008116 calcium stearate Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 208000006111 contracture Diseases 0.000 description 1
- 239000012050 conventional carrier Substances 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- GXGAKHNRMVGRPK-UHFFFAOYSA-N dimagnesium;dioxido-bis[[oxido(oxo)silyl]oxy]silane Chemical compound [Mg+2].[Mg+2].[O-][Si](=O)O[Si]([O-])([O-])O[Si]([O-])=O GXGAKHNRMVGRPK-UHFFFAOYSA-N 0.000 description 1
- 206010013023 diphtheria Diseases 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 230000001882 diuretic effect Effects 0.000 description 1
- MOTZDAYCYVMXPC-UHFFFAOYSA-N dodecyl hydrogen sulfate Chemical compound CCCCCCCCCCCCOS(O)(=O)=O MOTZDAYCYVMXPC-UHFFFAOYSA-N 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 description 1
- FCZCIXQGZOUIDN-UHFFFAOYSA-N ethyl 2-diethoxyphosphinothioyloxyacetate Chemical compound CCOC(=O)COP(=S)(OCC)OCC FCZCIXQGZOUIDN-UHFFFAOYSA-N 0.000 description 1
- 239000003172 expectorant agent Substances 0.000 description 1
- 230000003419 expectorant effect Effects 0.000 description 1
- 235000008384 feverfew Nutrition 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 210000002816 gill Anatomy 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000003862 health status Effects 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 235000012907 honey Nutrition 0.000 description 1
- 239000008172 hydrogenated vegetable oil Substances 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 210000003026 hypopharynx Anatomy 0.000 description 1
- 201000007227 lymph node tuberculosis Diseases 0.000 description 1
- 239000000391 magnesium silicate Substances 0.000 description 1
- 229940099273 magnesium trisilicate Drugs 0.000 description 1
- 229910000386 magnesium trisilicate Inorganic materials 0.000 description 1
- 235000019793 magnesium trisilicate Nutrition 0.000 description 1
- 201000004792 malaria Diseases 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 206010027599 migraine Diseases 0.000 description 1
- 230000001617 migratory effect Effects 0.000 description 1
- 201000008383 nephritis Diseases 0.000 description 1
- 231100000862 numbness Toxicity 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 238000005453 pelletization Methods 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 239000011435 rock Substances 0.000 description 1
- 230000009291 secondary effect Effects 0.000 description 1
- 210000001625 seminal vesicle Anatomy 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000019615 sensations Nutrition 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 206010040872 skin infection Diseases 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 description 1
- 239000007779 soft material Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 230000004206 stomach function Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 231100000886 tinnitus Toxicity 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 208000019206 urinary tract infection Diseases 0.000 description 1
- 201000010653 vesiculitis Diseases 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/77—Sapindaceae (Soapberry family), e.g. lychee or soapberry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/85—Verbenaceae (Verbena family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a traditional Chinese medicinal preparation for treating anemia as well as a preparation method and an application of the traditional Chinese medicinal preparation. The traditional Chinese medicinal preparation consists of flos gomphrenae, herb of siberian cocklebur, negundo chastetree fruits, herb of shortlobed wormwood and soapberries. The traditional Chinese medicinal preparation disclosed by the invention, according to a conventional traditional Chinese medicinal preparation method, can be prepared into any clinically acceptable oral medicinal preparations. The traditional Chinese medicinal preparation disclosed by the invention is broad in source of various components, simple in preparation process and low in cost; the traditional Chinese medicinal preparation has functions of enriching blood and nourishing blood, tonifying the spleen and harmonizing the stomach, supplementing qi and promoting production of body fluid, and tonifying the liver and kidney; and upon a clinical curative effect, the traditional Chinese medicinal preparation is exact and reliable in curative effect on treating the anemia, safe in clinical application and free from any toxic and side effects, and the traditional Chinese medicinal preparation is capable of treating both symptoms and root causes.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, particularly relate to a kind of Chinese medicine preparation treating anemia and preparation thereof
Method and purposes, belong to the treatment by Chinese herbs field of anemia.
Background technology
Anemia refers to that human peripheral blood erythrocyte volume a surname is few, common less than the one of lower limit normal range
Clinical symptoms.Anemia can without or have the most tired and dizzy；Anemia, movable or work
After pale complexion, dim eyesight, nervous and tachypnea occur；Anemia, even if when having a rest or lie in bed also
There is obvious symptom.Nineteen sixty-eight, World Health Organization (WHO) proposes: the hemoglobin of adult male is less than
130g/L, the hemoglobin of adult female can be diagnosed as anemia less than 120g/L person.
At present, for the symptom of anemia, most patient uses Western medicine to be controlled treatment, but Western medicine is secondary
Effect is big, and dependency is strong, cures the symptoms, not the disease, causes dosage increasing, cause vicious cycle.
Therefore, develop a kind of safe and effective Prospect of TCM New Products treating anemia to be significant.
Summary of the invention
An object of the present invention is to overcome existing medicine to there is, in treatment anemia, slow, the curative effect that takes effect
Not persistently, the defect such as big, the easy recurrence of toxic and side effects, it is provided that a kind of instant effect, determined curative effect, nothing
The prevention of toxic and side effects and the Chinese medicine preparation for the treatment of anemia；
The two of the purpose of the present invention are to provide a kind of method preparing above-mentioned Chinese medicine preparation.
For reaching above-mentioned purpose, the technical solution used in the present invention is:
First the present invention discloses a kind of Chinese medicine preparation treating anemia, including following component: thousand
Red, Herba Xanthii, Fructus Viticis Negundo, Herba Artemisiae Brachylobae and Fructus Sapindi Mukouossi；
Preferably, the weight portion of each component is: Flos Gomphrenae 30-40 part, Herba Xanthii 30-40 part, five-leaved chaste tree
Sub-20-30 part, Herba Artemisiae Brachylobae 5-9 part, Fructus Sapindi Mukouossi 3-7 part.
Most preferably, the weight portion of each component is: Flos Gomphrenae 35 parts, Herba Xanthii 35 parts, Fructus Viticis Negundo 25
Part, Herba Artemisiae Brachylobae 7 parts, Fructus Sapindi Mukouossi 5 parts.
Flos Gomphrenae is inflorescence or the herb of amaranthaceous plant Flos Gomphrenae.Nature and flavor: sweet are flat.Function cures mainly:
Liver heat removing, eliminating stagnation, relieving cough and relieving asthma.Control wind syndrome of head, ophthalmalgia, asthma and cough, dysentery, pertussis, children's
Infantile convulsion, scrofula steal, skin infection.For chronic or asthmatic bronchitis, pertussis.
Herba Xanthii is the stem and leaf of feverfew Herba Xanthii.Nature and flavor: toil, cold, poisonous.Function cures mainly: dispel
Wind dispels the heat, and detoxify parasite killing.Control wind syndrome of head, dizzy, arthralgia chiefly caused by damp pathogen contracture, conjunctival congestion, corneal nebula, wind leprosy, furuncle swells,
Pathopyretic ulcer, skin pruritus.
Fructus Viticis Negundo is the fruit of Verbenaceae five-leaved chaste tree.Nature and flavor: arduous, temperature.Function cures mainly: dispel
Wind, expectorant, circulation of qi promoting, pain relieving.Cure cold, cough, asthma, migratory arthralgia, malaria, stomachache, hernia,
Anal fistula.
Herba Artemisiae Brachylobae is the herb of chrysanthemum kind plant Herba Artemisiae Brachylobae.Nature and flavor: toil are flat.Function cures mainly: heat clearing and damp drying,
Parasite killing evacuation of pus.Control migraine, laryngopharynx swelling and pain, rheumatism.
Fructus Sapindi Mukouossi is that sapindaceous plant is without suffering from the seed of tree.Nature and flavor: bitter, flat, poisonous.Function master
Control: heat clearing away, eliminate the phlegm, removing food stagnancy, parasite killing.Control sore throat to swell and ache, cough with asthma, dyspepsia, leucorrhea, infantile malnutrition,
Skin ulcer numbness, toxic swelling.For diphtheria disease, seminal vesicle is sick, stranguria with turbid discharge frequent micturition.Heat clearing away, eliminates the phlegm, removing food stagnancy, parasite killing.
Sore throat swells and ache, cough with asthma, dyspepsia, leucorrhea, infantile malnutrition, skin ulcer tinea, toxic swelling.
The present invention further discloses a kind of Chinese medicine preparation treating anemia, including following component: thousand
Day red, Herba Xanthii, Fructus Viticis Negundo, Herba Artemisiae Brachylobae, Fructus Sapindi Mukouossi, Caulis Zizaniae caduciflorae and Herba Melicae Scabrosae.
Preferably, the weight portion of each component is: Flos Gomphrenae 30-40 part, Herba Xanthii 30-40 part, five-leaved chaste tree
Sub-20-30 part, Caulis Zizaniae caduciflorae 20-30 part, Herba Melicae Scabrosae 5-9 part, Herba Artemisiae Brachylobae 5-9 part, Fructus Sapindi Mukouossi 3-7 part；
Most preferably, the weight portion of each component is: Flos Gomphrenae 35 parts, Herba Xanthii 35 parts, Fructus Viticis Negundo 25
Part, Caulis Zizaniae caduciflorae 25 parts, Herba Melicae Scabrosae 7 parts, Herba Artemisiae Brachylobae 7 parts, Fructus Sapindi Mukouossi 5 parts.
Caulis Zizaniae caduciflorae is that the spindle that the scape of grass wild rice is formed through the stimulation of the black powder of Caulis Zizaniae caduciflorae is loose
Mycoceicidum.Nature and flavor: sweet in the mouth are nontoxic.Enter liver, spleen two warp.Function cures mainly: relieving heat toxin, relieving thirst and restlessness,
Profit two is just.Control dysphoria with smothery sensation, quench one's thirst, jaundice, dysentery, conjunctival congestion, wind skin ulcer.
Herba Melicae Scabrosae is the herb of grass Herba rutae.Nature and flavor: sweet are cool.Function cures mainly: diuretic leads to
Drench, heat clearing away.Control urinary tract infection, oedema due to nephritis, cat fever, icterohepatitis, diabetes.
The Chinese medicine preparation that the present invention is prepared by Flos Gomphrenae, Herba Xanthii, Fructus Viticis Negundo, Herba Artemisiae Brachylobae and Fructus Sapindi Mukouossi is to lean
Blood has certain therapeutic effect, and effective percentage reaches 68.0%.At Flos Gomphrenae, Herba Xanthii, Fructus Viticis Negundo, rock
Following groups medicine (1) Radix Polygoni Multiflori, Fructus Lycii (2) party is with the addition of respectively on the basis of Artemisia and Fructus Sapindi Mukouossi
Ginseng, Radix Angelicae Sinensis (3) Rhizoma Atractylodis Macrocephalae, Fructus Ligustri Lucidi (4) Radix Astragali, Poria (5) Fructus Jujubae, Radix Rehmanniae Preparata (6) water hay
In vain, Fructus Lycii (7) Herba Melicae Scabrosae, Fructus Lycii (8) Radix Polygoni Multiflori, Caulis Zizaniae caduciflorae (9) Radix Polygoni Multiflori, Herba Melicae Scabrosae (10)
Caulis Zizaniae caduciflorae, Radix Angelicae Sinensis (11) Herba Melicae Scabrosae, Radix Angelicae Sinensis (12) Caulis Zizaniae caduciflorae, Herba Melicae Scabrosae；By above-mentioned 12 groups of medicine groups
Compound prepares Chinese medicine preparation respectively, investigates its therapeutic effect to anemia.Test result indicate that, thousand
Add Caulis Zizaniae caduciflorae on the basis of day red, Herba Xanthii, Fructus Viticis Negundo, Herba Artemisiae Brachylobae and Fructus Sapindi Mukouossi, patient is had by Herba Melicae Scabrosae
Efficiency is up to 100%, is significantly higher than other combination.Illustrate Flos Gomphrenae, Herba Xanthii, Fructus Viticis Negundo, Herba Artemisiae Brachylobae,
Fructus Sapindi Mukouossi has definite Synergistic effect together with Caulis Zizaniae caduciflorae, Herba Melicae Scabrosae compatibility, is effectively increased
The effective percentage for the treatment of anemia.By contrast, by Flos Gomphrenae, Herba Xanthii, Fructus Viticis Negundo, Herba Artemisiae Brachylobae, Fructus Sapindi Mukouossi
After together with other several drugs compatibility, inconspicuous for improving the effect for the treatment of for anemia effect.
Chinese medicine preparation of the present invention is to the pathogenetic research of deep layer of anemia and treatment thereof based on inventor
Principle, simultaneously according to inventor's clinical experience for many years and pharmaceutical research achievement, filters out to have and enriches blood
Nourishing blood, dispersing liver and promoting blood circulation, clearing away heat-damp and promoting diuresis, the crude drug of removing toxic substances, according to certain weight proportion prescription
Become.
The present invention each medicine compatibility has blood-supplementing blood-nourishing, spleen reinforcing stomach function regulating, supplementing QI for promoting the production of body fluid, tonifying liver benefit together
Effect of kidney.Chinese medicine preparation of the present invention confirms for anemia treating both the principal and secondary aspects of a disease, clinical observation on the therapeutic effect, this
Bright Chinese medicine preparation is reliable for treatment anemia determined curative effect, true.Chinese medicine preparation of the present invention is nontoxic,
Safe and reliable, have no adverse reaction after taking, Clinical practice safety.
Each taste crude drug used by the present invention can be commercially available at pharmacy.
In the present invention on the basis of medicine preparation, add suitable adjuvant or carrier according to Chinese medicine conventional formulation
Method is prepared into treating the suitable clinical preparation of anemia；It is preferably oral formulations.
Described oral formulations includes electuary, pill, powder, granule, capsule, tablet, mouth
Take liquid or drop pill.
Described carrier or adjuvant refer to the conventional carrier of pharmaceutical field or adjuvant, such as: diluent, collapse
Split agent, lubricant, excipient, binding agent, fluidizer, filler, surfactant etc.；It addition,
Other adjuvant can also be added in the composition, such as flavouring agent and sweeting agent.Described diluent can be
One or more increase tablet weight and compositions of volume, conventional diluent include lactose, starch,
Pregelatinized Starch, microcrystalline Cellulose, sorbitol, mannitol and inorganic calcium salt etc.；Most common of which
For lactose, starch, microcrystalline Cellulose.Described disintegrating agent can be crospolyvinylpyrrolidone, hands over
Connection one of sodium carboxymethyl cellulose, alginic acid, microcrystalline Cellulose are planted or several mixture；Wherein with
Crospolyvinylpyrrolidone, cross-linking sodium carboxymethyl cellulose is preferred.Described lubricant includes tristearin
Acid, sodium stearate, magnesium stearate, calcium stearate, Polyethylene Glycol, Pulvis Talci, in hydrogenated vegetable oil
One or more mixture；Wherein most widely suited with magnesium stearate.Described binding agent can be one
Plant or several composition being conducive to pelletizing；Can be starch slurry, hydroxypropyl methyl cellulose, polyethylene
Ketopyrrolidine, is preferred with the ethanol water of polyvinylpyrrolidone.Described fluidizer can be micropowder
One of silica gel, Pulvis Talci, magnesium trisilicate are planted or several mixture.Described surfactant can be
One or more can improve wettability and increase the composition of drug-eluting, commonly use as lauryl sulphate acid
Sodium.
A kind of preparation method of Chinese medicine preparation of the present invention, comprises the following steps: take each raw material of the present invention
Medicine, pulverizes, sieve (can be such as 100-300 mesh sieve), to obtain final product.It is of course also possible to will be each
After crude drug is pulverized, add the adjuvant needed for preparations shaping or excipient, be conventionally prepared as
Required dosage form.
The another kind of preparation method of Chinese medicine preparation of the present invention: take each crude drug；By each crude drug decocting
Boiling, merge decoction liquor, filter, filtrate is condensed into clear paste, adds adjuvant or the excipient of preparations shaping,
Preparations shaping, to obtain final product.
The usage of Chinese medicine preparation of the present invention and consumption: the dosage of the present invention depends on concrete dosage form, disease
The factors such as the age of people, health status.As guidance: usage and dosage: oral, the most oral 1 to
2 bags, 3 times on the one, 10 days be a course for the treatment of, altogether 4-5 the course for the treatment of of treatment.
Technical solution of the present invention compared with prior art, has the advantages that
The compatibility of Chinese medicine preparation of the present invention is reasonable, it is possible to significantly improve the effective percentage for the treatment of anemia, curative effect
Definitely.Chinese medicine preparation of the present invention is pure Chinese medicinal preparation, and treating both the principal and secondary aspects of a disease has no side effect, and each component is come
Source is extensive, and preparation technology is simple, with low cost, has a good application prospect.
Detailed description of the invention
Further describing the present invention below in conjunction with specific embodiment, these embodiments are only exemplary,
It will be understood by those skilled in the art that can be to this under without departing from the spirit and scope of the present invention
The details of inventive technique scheme and form are modified or replace, but these amendments and replacement each fall within this
In the protection domain of invention.
The preparation of embodiment 1 electuary
Weigh each crude drug by following weight: Flos Gomphrenae 3.0kg, Herba Xanthii 3.0kg, Fructus Viticis Negundo 2.0kg,
Herba Artemisiae Brachylobae 0.5kg, Fructus Sapindi Mukouossi 0.3kg；By above-mentioned each crude drug boiling secondary, add 4 times for the first time
The water of weight, decocts 2 hours, and second time adds the water of 5 times of weight, decocts 1.5 hours；To decoct
Liquid merges, and filters, and filtrate is concentrated into the clear paste that relative density is 1.17-1.19 (60 DEG C)；Add suitable
The white sugar of amount, dextrin, mix homogeneously, then add appropriate amount of ethanol and make granule, packaging, to obtain final product.
The preparation of embodiment 2 electuary
Weigh each crude drug by following weight: Flos Gomphrenae 4.0kg, Herba Xanthii 4.0kg, Fructus Viticis Negundo 3.0kg,
Herba Artemisiae Brachylobae 0.9kg, Fructus Sapindi Mukouossi 0.7kg；By above-mentioned each crude drug boiling secondary, add 4 times for the first time
The water of weight, decocts 2 hours, and second time adds the water of 5 times of weight, decocts 1.5 hours；To decoct
Liquid merges, and filters, and filtrate is concentrated into the clear paste that relative density is 1.17-1.19 (60 DEG C)；Add suitable
The white sugar of amount, dextrin, mix homogeneously, then add appropriate amount of ethanol and make granule, packaging, to obtain final product.
The preparation of embodiment 3 electuary
Weigh each crude drug by following weight: Flos Gomphrenae 3.5kg, Herba Xanthii 3.5kg, Fructus Viticis Negundo 2.5kg,
Herba Artemisiae Brachylobae 0.7kg, Fructus Sapindi Mukouossi 0.5kg；By above-mentioned each crude drug boiling secondary, add 4 times for the first time
The water of weight, decocts 2 hours, and second time adds the water of 5 times of weight, decocts 1.5 hours；To decoct
Liquid merges, and filters, and filtrate is concentrated into the clear paste that relative density is 1.17-1.19 (60 DEG C)；Add suitable
The white sugar of amount, dextrin, mix homogeneously, then add appropriate amount of ethanol and make granule, packaging, to obtain final product.
The preparation of embodiment 4 electuary
Weigh each crude drug by following weight: Flos Gomphrenae 3.0kg, Herba Xanthii 3.0kg, Fructus Viticis Negundo 2.0kg,
Caulis Zizaniae caduciflorae 2.0kg, Herba Melicae Scabrosae 0.5kg, Herba Artemisiae Brachylobae 0.5kg, Fructus Sapindi Mukouossi 0.3kg；Above-mentioned each crude drug is added
Soak by water secondary, adds the water of 4 times of weight for the first time, decocts 2 hours, and second time adds 5 times of weight
Water, decocts 1.5 hours；Decoction liquor being merged, filter, it is 1.17-1.19 that filtrate is concentrated into relative density
The clear paste of (60 DEG C)；Add appropriate white sugar, dextrin, mix homogeneously, then add appropriate amount of ethanol system
Become granule, packaging, to obtain final product.
The preparation of embodiment 5 electuary
Weigh each crude drug by following weight: Flos Gomphrenae 4.0kg, Herba Xanthii 4.0kg, Fructus Viticis Negundo 3.0kg,
Caulis Zizaniae caduciflorae 3.0kg, Herba Melicae Scabrosae 0.9kg, Herba Artemisiae Brachylobae 0.9kg, Fructus Sapindi Mukouossi 0.7kg；Above-mentioned each crude drug is added
Soak by water secondary, adds the water of 4 times of weight for the first time, decocts 2 hours, and second time adds 5 times of weight
Water, decocts 1.5 hours；Decoction liquor being merged, filter, it is 1.17-1.19 that filtrate is concentrated into relative density
The clear paste of (60 DEG C)；Add appropriate white sugar, dextrin, mix homogeneously, then add appropriate amount of ethanol system
Become granule, packaging, to obtain final product.
The preparation of embodiment 6 electuary
Weigh each crude drug by following weight: Flos Gomphrenae 3.5kg, Herba Xanthii 3.5kg, Fructus Viticis Negundo 2.5kg,
Caulis Zizaniae caduciflorae 2.5kg, Herba Melicae Scabrosae 0.7kg, Herba Artemisiae Brachylobae 0.7kg, Fructus Sapindi Mukouossi 0.5kg；Above-mentioned each crude drug is added
Soak by water secondary, adds the water of 4 times of weight for the first time, decocts 2 hours, and second time adds 5 times of weight
Water, decocts 1.5 hours；Decoction liquor being merged, filter, it is 1.17-1.19 that filtrate is concentrated into relative density
The clear paste of (60 DEG C)；Add appropriate white sugar, dextrin, mix homogeneously, then add appropriate amount of ethanol system
Become granule, packaging, to obtain final product.
The preparation of embodiment 7 pill
Weigh each crude drug by following weight: Flos Gomphrenae 3.5kg, Herba Xanthii 3.5kg, Fructus Viticis Negundo 2.5kg,
Caulis Zizaniae caduciflorae 2.5kg, Herba Melicae Scabrosae 0.7kg, Herba Artemisiae Brachylobae 0.7kg, Fructus Sapindi Mukouossi 0.5kg；Above-mentioned each crude drug is added
Soak by water secondary, adds the water of 4 times of weight for the first time, decocts 2 hours, and second time adds 5 times of weight
Water, decocts 1.5 hours；Decoction liquor being merged, filter, it is 1.17-1.19 that filtrate is concentrated into relative density
The clear paste of (60 DEG C)；Add appropriate refined honey, mixing, it is prepared as the pill of every 6g.
The preparation of embodiment 8 tablet
Weigh each crude drug by following weight: Flos Gomphrenae 3.5kg, Herba Xanthii 3.5kg, Fructus Viticis Negundo 2.5kg,
Caulis Zizaniae caduciflorae 2.5kg, Herba Melicae Scabrosae 0.7kg, Herba Artemisiae Brachylobae 0.7kg, Fructus Sapindi Mukouossi 0.5kg；Above-mentioned each crude drug is added
Soak by water secondary, adds the water of 4 times of weight for the first time, decocts 2 hours, and second time adds 5 times of weight
Water, decocts 1.5 hours；Decoction liquor being merged, filter, it is 1.17-1.19 that filtrate is concentrated into relative density
The clear paste of (60 DEG C)；Add appropriate amount of starch, mix homogeneously, then mix homogeneously with dextrin, add ethanol
(50%) soft material the most processed；Being pelletized by 16 mesh nylon mesh, be dried at 60 DEG C, dry granular is after 16 mesh
Sieve granulate, adds appropriate magnesium stearate, tabletting after mix homogeneously.
The preparation of embodiment 9 capsule
Weigh each crude drug by following weight: Flos Gomphrenae 3.5kg, Herba Xanthii 3.5kg, Fructus Viticis Negundo 20.5kg,
Caulis Zizaniae caduciflorae 2.5kg, Herba Melicae Scabrosae 0.7kg, Herba Artemisiae Brachylobae 0.7kg, Fructus Sapindi Mukouossi 0.5kg；Above-mentioned each crude drug is added
Soak by water secondary, adds the water of 4 times of weight for the first time, decocts 2 hours, and second time adds 5 times of weight
Water, decocts 1.5 hours；Decoction liquor being merged, filter, it is 1.17-1.19 that filtrate is concentrated into relative density
The clear paste of (60 DEG C)；Add appropriate amount of starch, mix homogeneously, add appropriate amount of ethanol and make granule, be dried,
Granulate, fills capsule, to obtain final product.
Experimental example 1 applies the clinical observation on the therapeutic effect test of Chinese medicine preparation of the present invention treatment anemia
One, physical data:
650 example patients all meet the diagnostic criteria of anemia, patient is randomly divided into 13 groups, often organizes 50
Example；13 groups of no significant differences on sex, age, the course of disease and coincident with severity degree of condition.Clinical manifestation:
The most tired and dizzy；Pale complexion, dim eyesight, nervous and tachypnea occur after activity or work；Memory
Power goes down, cardiopalmus, breathe hard, uncomfortable in chest；Light red tongne, the symptom such as thready pulse without strength.
Two, prepared by medicine
Chinese medicine preparation 1, weighs each component according to following weight: Flos Gomphrenae 3.5kg, Herba Xanthii 3.5kg,
Fructus Viticis Negundo 2.5kg, Herba Artemisiae Brachylobae 0.7kg, Fructus Sapindi Mukouossi 0.5kg；
By above-mentioned each crude drug boiling secondary, add the water of 4 times of weight for the first time, decoct 2 hours,
Second time adds the water of 5 times of weight, decocts 1.5 hours；Decoction liquor being merged, filter, filtrate concentrates
To the clear paste that relative density is 1.17-1.19 (60 DEG C)；Add appropriate white sugar, dextrin, mixing
Uniformly, then add appropriate amount of ethanol and make granule, packaging, to obtain final product.
Chinese medicine preparation 2: add Radix Polygoni Multiflori 2.5kg, Fructus Lycii 0.7kg on the basis of Chinese medicine preparation 1；
Chinese medicine preparation 3: add Radix Codonopsis 2.5kg, Radix Angelicae Sinensis 0.7kg on the basis of Chinese medicine preparation 1；
Chinese medicine preparation 4: add Rhizoma Atractylodis Macrocephalae 2.5kg, Fructus Ligustri Lucidi 0.7kg on the basis of Chinese medicine preparation 1；
Chinese medicine preparation 5: add Radix Astragali 2.5kg, Poria 0.7kg on the basis of Chinese medicine preparation 1；
Chinese medicine preparation 6: add Fructus Jujubae 2.5kg, Radix Rehmanniae Preparata 0.7kg on the basis of Chinese medicine preparation 1；
Chinese medicine preparation 7: add Caulis Zizaniae caduciflorae 2.5kg, Fructus Lycii 0.7kg on the basis of Chinese medicine preparation 1；
Chinese medicine preparation 8: add Herba Melicae Scabrosae 2.5kg, Fructus Lycii 0.7kg on the basis of Chinese medicine preparation 1；
Chinese medicine preparation 9: add Radix Polygoni Multiflori 2.5kg, Caulis Zizaniae caduciflorae 0.7kg on the basis of Chinese medicine preparation 1；
Chinese medicine preparation 10: add Radix Polygoni Multiflori 2.5kg, Herba Melicae Scabrosae 0.7kg on the basis of Chinese medicine preparation 1；
Chinese medicine preparation 11: add Caulis Zizaniae caduciflorae 2.5kg, Radix Angelicae Sinensis 0.7kg on the basis of Chinese medicine preparation 1；
Chinese medicine preparation 12: add Herba Melicae Scabrosae 2.5kg, Radix Angelicae Sinensis 0.7kg on the basis of Chinese medicine preparation 1；
Chinese medicine preparation 13: add Caulis Zizaniae caduciflorae 2.0kg, Herba Melicae Scabrosae 0.7kg on the basis of Chinese medicine preparation 1；
The preparation method of Chinese medicine preparation 2-13 is with Chinese medicine preparation 1.
Three, Therapeutic Method
With the electuary of above-mentioned Chinese medicine preparation 1-13, above-mentioned 13 groups of Anemic patients are treated respectively；Mouthful
Clothes, the most oral 1 to 2 bag, 3 times on the one, 10 days be a course for the treatment of, altogether 4 courses for the treatment of of treatment；
Other related drugs and other treatment is withdrawn during taking medicine.
Four, efficacy assessment standard
Cure: clinical symptoms and sign disappear or substantially disappear；
Effective: clinical symptoms and sign are eased；
Invalid: clinical symptoms and sign the most do not obtain any alleviation.
Five, clinical observation result
Clinical observation result is shown in Table 1.
The statistical result of table 1 different Chinese medicine preparation treatment anemia
Result shows, Flos Gomphrenae, Herba Xanthii, Fructus Viticis Negundo, Herba Artemisiae Brachylobae, Fructus Sapindi Mukouossi the Chinese medicine preparation prepared
1 pair of anemia has certain therapeutic effect, and effective percentage reaches 68.0%.Flos Gomphrenae, Herba Xanthii, five-leaved chaste tree
On the basis of son, Herba Artemisiae Brachylobae, Fructus Sapindi Mukouossi, add Caulis Zizaniae caduciflorae, Herba Melicae Scabrosae, notable to the effective percentage for the treatment of anemia
Improve, reach 100%.
These results suggest that, Flos Gomphrenae, Herba Xanthii, Fructus Viticis Negundo, Herba Artemisiae Brachylobae, Fructus Sapindi Mukouossi and Caulis Zizaniae caduciflorae, spun gold
There is between grass significant synergistic function, its compatibility can be significantly improved treatment anemia together
Effective percentage.By contrast, Flos Gomphrenae, Herba Xanthii, Fructus Viticis Negundo, Herba Artemisiae Brachylobae, Fructus Sapindi Mukouossi is several with other
Kind of compatibility of drugs together after, inconspicuous for improving the effect for the treatment of for anemia effect.Safety observations
Find, do not observe any clinical adverse, show Chinese medicine preparation clinical practice of the present invention safety,
Have no side effect.
The model case of experimental example 2 Chinese medicine preparation treatment anemia
Zhao, man, 25 years old, in mid-May, 2014, one month in succession, have breathe hard,
The symptoms such as cardiopalmus, inappetence, lean body mass, are anemia after diagnosing, take the embodiment of the present invention 6
Prepared electuary, three times on the one, one time 2 bags, after 2 courses for the treatment of, major part transference cure, 3
Fully recover after the individual course for the treatment of, follow up a case by regular visits to 1 year have no recurrence.
Liu so-and-so, female, 42 years old, on July 12nd, 2014, green around the gills occurs, weak, tinnitus,
Come here to go to a doctor, be anemia after diagnosing.Take pill prepared by the embodiment of the present invention 7 three times on the one,
3 balls, after treating a course for the treatment of, symptom has been alleviated, and after 2 courses for the treatment of, major part symptom is
Eliminate, fully recover after 3 courses for the treatment of, follow up a case by regular visits to not recur half a year.
Go into business certain, man, 19 years old, because of sore waist and aching in the waist and the back, tachypnea, weak, irritated come here go to a doctor, through examining
Break as anemia.Take the capsule prepared by the embodiment of the present invention 9, three times on the one, one time 4,
Fully recover after treating two courses for the treatment of, for consolidating curative effect, continue to take a course for the treatment of, follow up a case by regular visits to not recur half a year.
Claims (8)
1. the Chinese medicine preparation treating anemia, it is characterised in that be made up of following component: thousand days
Red, Herba Xanthii, Fructus Viticis Negundo, Herba Artemisiae Brachylobae and Fructus Sapindi Mukouossi.
2. according to the Chinese medicine preparation described in claim 1, it is characterised in that the weight portion of each component is:
Flos Gomphrenae 30-40 part, Herba Xanthii 30-40 part, Fructus Viticis Negundo 20-30 part, Herba Artemisiae Brachylobae 5-9 part, Fructus Sapindi Mukouossi
3-7 part.
3. according to the Chinese medicine preparation described in claim 2, it is characterised in that the weight portion of each component is:
Flos Gomphrenae 35 parts, Herba Xanthii 35 parts, Fructus Viticis Negundo 25 parts, Herba Artemisiae Brachylobae 7 parts, Fructus Sapindi Mukouossi 5 parts.
4. the Chinese medicine preparation treating anemia, it is characterised in that be made up of following component: thousand days
Red, Herba Xanthii, Fructus Viticis Negundo, Herba Artemisiae Brachylobae, Fructus Sapindi Mukouossi, Caulis Zizaniae caduciflorae and Herba Melicae Scabrosae.
5. according to the Chinese medicine preparation described in claim 4, it is characterised in that the weight portion of each component is:
Flos Gomphrenae 30-40 part, Herba Xanthii 30-40 part, Fructus Viticis Negundo 20-30 part, Caulis Zizaniae caduciflorae 20-30 part, Herba Melicae Scabrosae
5-9 part, Herba Artemisiae Brachylobae 5-9 part, Fructus Sapindi Mukouossi 3-7 part.
6. according to the Chinese medicine preparation described in claim 5, it is characterised in that the weight portion of each component is:
Flos Gomphrenae 35 parts, Herba Xanthii 35 parts, Fructus Viticis Negundo 25 parts, Caulis Zizaniae caduciflorae 25 parts, Herba Melicae Scabrosae 7 parts, Herba Artemisiae Brachylobae
7 parts, Fructus Sapindi Mukouossi 5 parts.
7. prepare a method for Chinese medicine preparation described in claim 1-6 any one, including following step
Rapid: to take each component, mixing；With soak by water, merging decoction liquor, filter, filtrate is condensed into clear paste,
Add adjuvant or excipient, the preparations shaping of preparations shaping, to obtain final product.
8. the use in preparation treatment anemia medicine of the Chinese medicine preparation described in claim 1-6 any one
On the way.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610319015.3A CN105943720A (en) | 2016-05-13 | 2016-05-13 | Traditional Chinese medicinal preparation for treating anemia as well as preparation method and application of traditional Chinese medicinal preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610319015.3A CN105943720A (en) | 2016-05-13 | 2016-05-13 | Traditional Chinese medicinal preparation for treating anemia as well as preparation method and application of traditional Chinese medicinal preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105943720A true CN105943720A (en) | 2016-09-21 |
Family
ID=56912501
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610319015.3A Pending CN105943720A (en) | 2016-05-13 | 2016-05-13 | Traditional Chinese medicinal preparation for treating anemia as well as preparation method and application of traditional Chinese medicinal preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105943720A (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101940740A (en) * | 2010-09-19 | 2011-01-12 | 张小红 | Chinese medicinal preparation for treating anemia and preparation method thereof |
| CN103392882A (en) * | 2013-08-08 | 2013-11-20 | 常熟市海虞茶叶有限公司 | Anemia preventing tea |
| CN103655801A (en) * | 2014-01-02 | 2014-03-26 | 王晓翠 | Medicine for treating anemia |
| CN104689040A (en) * | 2013-12-05 | 2015-06-10 | 陕西康乐中医药养生研究院 | Chinese medicinal preparation for treatment of anemia |
| CN105055660A (en) * | 2015-09-22 | 2015-11-18 | 孙华堂 | Traditional Chinese medicine preparation for treating anemia |
-
2016
- 2016-05-13 CN CN201610319015.3A patent/CN105943720A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101940740A (en) * | 2010-09-19 | 2011-01-12 | 张小红 | Chinese medicinal preparation for treating anemia and preparation method thereof |
| CN103392882A (en) * | 2013-08-08 | 2013-11-20 | 常熟市海虞茶叶有限公司 | Anemia preventing tea |
| CN104689040A (en) * | 2013-12-05 | 2015-06-10 | 陕西康乐中医药养生研究院 | Chinese medicinal preparation for treatment of anemia |
| CN103655801A (en) * | 2014-01-02 | 2014-03-26 | 王晓翠 | Medicine for treating anemia |
| CN105055660A (en) * | 2015-09-22 | 2015-11-18 | 孙华堂 | Traditional Chinese medicine preparation for treating anemia |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102342992B (en) | Chinese medicinal composition for treating insomnia and preparation method of preparation thereof | |
| CN101797352B (en) | Chinese medicinal composition for treating lassitude hypodynamia and preparation method thereof | |
| CN103990081A (en) | Traditional Chinese medicine composition and application thereof in preparation of medicine for treating infant jaundice | |
| CN102293975B (en) | Medicine for treating phthisis and preparation method thereof | |
| CN105535471A (en) | Pill medicine for treating panasthenia and preparation method thereof | |
| CN105663656A (en) | Pharmaceutical composition for treating sleep disorders and preparing method thereof | |
| CN104491236A (en) | Traditional Chinese medicine preparation for treating essential hypertension and preparation method for traditional Chinese medicine preparation | |
| CN106620516A (en) | Traditional Chinese medicine composition used for health maintenance and weight loss as well as preparation and preparation method thereof | |
| CN106138785A (en) | One treats neurasthenic Chinese medicine composition and preparation method thereof | |
| CN105232999A (en) | Traditional Chinese medicine composition for tonifying qi, activating blood and controlling nocturnal emission | |
| CN104491318A (en) | Traditional Chinese preparation used for treating asthma and preparation method of traditional Chinese preparation | |
| CN104998005A (en) | Traditional Chinese medicine oral liquid special for treating constipation and preparation method thereof | |
| CN104096073A (en) | Traditional Chinese medicine composition for treating male infertility and preparation method for same | |
| CN103656199B (en) | A kind of Chinese medicine for the treatment of deficiency of kidney yin syndrome cough | |
| CN105943720A (en) | Traditional Chinese medicinal preparation for treating anemia as well as preparation method and application of traditional Chinese medicinal preparation | |
| CN103349709B (en) | Traditional Chinese medicine preparation capable of tonifying qi and yin and nourishing liver and kidney | |
| CN107596230A (en) | A kind of new medicine composition for treating acne rosacea and preparation method thereof | |
| CN105327003A (en) | Traditional Chinese medicine for treating cardiovascular diseases and preparation method thereof | |
| CN105250618A (en) | Antiviral traditional Chinese medicine composition for treating liver cirrhosis and preparation method thereof | |
| CN105250749A (en) | Traditional Chinese medicine for treating thyroid adenoma and preparation method thereof | |
| CN104740396A (en) | Traditional Chinese medicine for treating kidney stones and preparation method of traditional Chinese medicine | |
| CN104306565A (en) | Traditional Chinese medicine preparation for treating qi stagnation and blood stasis type angina pectoris and preparation method thereof | |
| CN103330896A (en) | Preparation method of powder for treating postpartum nonspecific vaginitis | |
| CN102743682A (en) | Chinese medicinal pill for preventing miscarriage of pregnant woman | |
| CN107929583A (en) | A kind of medicine for treating the cataractogenic medicine of lenticular opacities and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160921 |