CN105866077A - Time-resolved fluorescence analysis system and detection apparatus - Google Patents

Time-resolved fluorescence analysis system and detection apparatus Download PDF

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Publication number
CN105866077A
CN105866077A CN201610166288.9A CN201610166288A CN105866077A CN 105866077 A CN105866077 A CN 105866077A CN 201610166288 A CN201610166288 A CN 201610166288A CN 105866077 A CN105866077 A CN 105866077A
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China
Prior art keywords
time
motor
light source
resolved fluorescence
reagent strip
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Pending
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CN201610166288.9A
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Chinese (zh)
Inventor
刘玉县
梁伟棠
陈庆明
林晓明
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Guangdong Zhicheng Biotechnology Co., Ltd.
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Guangdong Shunde Industrial Design Institute
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Priority to CN201610166288.9A priority Critical patent/CN105866077A/en
Publication of CN105866077A publication Critical patent/CN105866077A/en
Pending legal-status Critical Current

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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6408Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence

Abstract

The invention discloses a time-resolved fluorescence analysis system and a detection apparatus. The time-resolved fluorescence analysis system comprises a guide rail, a first motor, an optical detection unit, a light source and a control unit, wherein the first motor, the optical detection unit and the light source are all electrically connected with the control unit; the guide rail is used for placing a reagent strip and carrying the reagent strip to the optical detection unit for scanning and detection under the driving of the first motor; and the control unit is used for controlling turning-on of the light source for irradiation of the reagent strip. After first preset time, the light source is turned off, the optical detection unit is turned on to detect fluorescence emitted by the reagent strip, and an converted electric signal output to the control unit for processing; after second preset time, the optical detection unit is turned off, and the first motor is controlled to rotate by one step length; and the above-mentioned steps are repeated until scanning and detection of the reagent strip are completed. The time-resolved fluorescence analysis system has the advantages of simple structure and low cost.

Description

Time-resolved fluorescence assay system and detection device
Technical field
The present invention relates to fluorescent mark immunity sample detection technical field, particularly to a kind of Time-resolved fluorescence assay system System and apply the detection device of this Time-resolved fluorescence assay system.
Background technology
Time-resolved fluoroimmunoassay chromatographic technique is a kind of non-isotop analysis technology, and it resists with lanthanide series labelling Former or antibody, according to the luminous characteristics of lanthanide chelate, measures fluorescence by TIME RESOLVED TECHNIQUE, simultaneously detection wavelength and time Between two parameters carry out signal resolution, can effectively get rid of the interference of non-specific fluorescence, drastically increase sensitivity for analysis, because of This is widely used.
Existing time-resolved fluoroimmunoassay chromatographic analysis instrument be obtain bigger Stokes (Stokes shift, the most identical Electron transition difference between absorption spectrum and emission spectrum high-amplitude wave length) displacement, generally use rare earth metal, such as europium (Eu3 +) ion carries out fluorescent labeling, and fluorescence detection method is all to add fixing optical system after fluorescent material for collimating And focusing, finally enter photoelectric sensor.The optical detecting module of optical system thus can be made to need light path to build, increase The complexity of system.
Summary of the invention
The main object of the present invention is to provide a kind of Time-resolved fluorescence assay system, it is intended to simplied system structure, reduces Cost.
For achieving the above object, the present invention proposes a kind of Time-resolved fluorescence assay system, including guide rail, the first electricity Machine, optical detection unit, light source and control unit;Described first motor, optical detection unit and light source all control list with described Unit's electrical connection;Wherein,
Described guide rail, is used for placing reagent strip and reagent strip delivery being examined to described optics under described first motor drives Survey module and be scanned detection;
Described control unit, is used for controlling the unlatching of described light source and is irradiated described reagent strip;At the first Preset Time Rear shutoff light source is also opened the signal of telecommunication that the fluorescence that reagent strip sends by optical detection unit detects and be converted into and is exported extremely Control unit processes;After the second Preset Time, close optical detection unit and control described first electric machine rotation one Step-length;Repeat the above steps is until the scanned detection of reagent strip is complete.
Preferably, described Time-resolved fluorescence assay system also includes host computer unit, and described host computer unit is with described Control unit electrically connects.
Preferably, described optical detection unit includes photoelectric sensor;Described photoelectric sensor is with described control unit even Connect;Described host computer according to the data genaration abscissa of photoelectric sensor collection be time, vertical coordinate be the curve of light intensity.
Preferably, described Time-resolved fluorescence assay system also includes attenuator;Described optical detection unit is formed glimmering Light sense channel, described attenuator is arranged in fluorescence detection channel.
Preferably, described Time-resolved fluorescence assay system also includes narrow band pass filter;Described narrow band pass filter is arranged at In described fluorescence detection channel;After the fluorescence that described reagent strip sends is by described narrow band pass filter and described attenuator, by institute State photoelectric sensor to detect.
Preferably, described Time-resolved fluorescence assay system also includes the second motor, described second motor and described decay Sheet is connected by gear mesh;Described control unit controls described second motor step-length and turns to, and drives described attenuator to rotate The fluorescence intensity sending described reagent strip decays.
Preferably, described control unit includes single-chip microcomputer, the first drive circuit, the second drive circuit, analog-digital converter, light Source driving circuit and filter circuit;Described single-chip microcomputer drives electricity with described first drive circuit, the second drive circuit, light source respectively Road, described analog-digital converter and the electrical connection of described host computer;One end of described filter circuit is connected with described analog-digital converter, separately Photoelectric sensor described in one end connects;Described first motor is connected with described first drive circuit;Described second motor is with described Second drive circuit connects;Described light source is connected with described light source driving circuit.
Preferably, described light source uses LED.
Preferably, described first motor and described second motor all use motor.
The present invention also proposes a kind of detection device, and described detection device includes Time-resolved fluorescence assay system as above System;Described Time-resolved fluorescence assay system includes guide rail, the first motor, optical detection unit, light source and control unit;Described First motor, optical detection unit and light source all electrically connect with described control unit;Wherein, described guide rail, it is used for placing reagent Reagent strip delivery is also scanned detection to described optical detecting module under described first motor drives by bar;Described control is single Unit, is used for controlling the unlatching of described light source and is irradiated described reagent strip;After the first Preset Time, turn off light source and open light The signal of telecommunication output that the fluorescence that reagent strip is sent by detector unit detects and is converted into processes to control unit; After the second Preset Time, close optical detection unit and control described one step-length of first electric machine rotation;Repeat the above steps is straight Complete to the scanned detection of reagent strip.
Technical solution of the present invention, by arranging guide rail, the first motor, optical detection unit, light source and control unit, is formed A kind of Time-resolved fluorescence assay system.Described first motor drives described guide rail to move along a direction, is delivered by reagent strip Detection it is scanned to described optical detecting module;Described control unit controls the unlatching of described light source and carries out described reagent strip Irradiate;After the first Preset Time, turn off light source and open the fluorescence that reagent strip sends by optical detection unit and detect and turn Change the signal of telecommunication into process;After the second Preset Time, close optical detection unit and control described first electric machine rotation one Individual step-length;Repeat the above steps is until the scanned detection of reagent strip is complete.The optical detecting module simple in construction of the present invention, is not required to Want optical system collimation focusing, easy to operate, reduce the cost of instrument.
Accompanying drawing explanation
In order to be illustrated more clearly that the embodiment of the present invention or technical scheme of the prior art, below will be to embodiment or existing In having technology to describe, the required accompanying drawing used is briefly described, it should be apparent that, the accompanying drawing in describing below is only this Some embodiments of invention, for those of ordinary skill in the art, on the premise of not paying creative work, it is also possible to Other accompanying drawing is obtained according to the structure shown in these accompanying drawings.
Fig. 1 is the functional block diagram of Time-resolved fluorescence assay system one embodiment of the present invention.
Drawing reference numeral illustrates:
Label Title Label Title
100 Guide rail 530 Second drive circuit
200 First motor 540 Light source driving circuit
300 Optical detection unit 550 Analog-digital converter
400 Light source 560 Filter circuit
500 Control unit 600 Reagent strip
510 Single-chip microcomputer 700 Host computer
520 First drive circuit 800 Second motor
The realization of the object of the invention, functional characteristics and advantage will in conjunction with the embodiments, are described further referring to the drawings.
Detailed description of the invention
Below in conjunction with the accompanying drawing in the embodiment of the present invention, the technical scheme in the embodiment of the present invention is carried out clear, complete Describe, it is clear that described embodiment is only a part of embodiment of the present invention rather than whole embodiments wholely.Base Embodiment in the present invention, those of ordinary skill in the art obtained under not making creative work premise all its His embodiment, broadly falls into the scope of protection of the invention.
It is to be appreciated that be only used for describing purpose as related to the description of " first ", " second " etc. in the present invention, and can not manage Solve as instruction or imply its relative importance or the implicit quantity indicating indicated technical characteristic.Thus, define " the One ", the feature of " second " can express or implicitly include at least one this feature.It addition, the skill between each embodiment Art scheme can be combined with each other, but must be based on those of ordinary skill in the art are capable of, when technical scheme People should think that the combination of this technical scheme does not exists when maybe cannot realize in conjunction with appearance is conflicting, not want in the present invention Within the protection domain asked.
The present invention proposes a kind of Time-resolved fluorescence assay system.
With reference to Fig. 1, in embodiments of the present invention, this Time-resolved fluorescence assay system, including guide rail the 100, first motor 200, optical detection unit 300, light source 400 and control unit 500;Described first motor 200, optical detection unit 300 and light Source 400 all electrically connects with described control unit 500.
Wherein, described guide rail 100 is used for placing reagent strip 600 and by reagent strip 600 under described first motor 200 drives Delivery to described optical detection unit 300 is scanned detection;Described control unit 500 is used for controlling described light source 400 and opens Described reagent strip 600 is irradiated;After the first Preset Time, turn off light source 400 and open optical detection unit 300, to examination The fluorescence that agent bar 600 sends carries out detecting and be converted into signal of telecommunication output and processes to control unit 500;When second presets Close optical detection unit 300 after between and control described first motor 200 and rotate a step-length;Repeat the above steps is until reagent The scanned detection of bar 600 is complete.
It should be noted that when carrying out sample detection, reagent strip 600 is positioned on guide rail 100, by the first motor 200 drive, and are delivered to described optical detection unit 300 by reagent strip 600;Now control unit 500 controls light source 400 and opens Open, described reagent strip 600 is irradiated, after maintaining the first preset time period, start optical detection unit 300 the most at once The fluorescence intensity that on detectable bar, labelling produce are raw.In the case of not having the light of light source 400 as background, detection obtains Fluorescence is exactly the fluorescence signal of intrinsic, eliminates the impact of light source 400, thus improves signal to noise ratio.
After extinguishing due to light source 400, the fluorescence that reagent strip 600 produces is held time limited.Label in the present embodiment Using europium ion, europium element produces fluorescence times about 1 millisecond after being excited, and therefore the fluorescent collecting time not can exceed that fluorescence is held The continuous time.After a cycle fluorescent collecting completes, control unit 500 controls guide rail 100 and moves a step distance, and repeats Excite the fluorescent material on reagent strip 600 and gather fluorescence signal process, until the optical sensitive sector scanning in test strips 600 Complete.
Technical solution of the present invention is by arranging guide rail the 100, first motor 200, optical detection unit 300, light source 400 and control Unit 500 processed, defines a kind of Time-resolved fluorescence assay system.Described first motor 200 drives described guide rail 100 along a side To movement, reagent strip 600 is delivered to described optical detection unit 300, is scanned detection;Described control unit 500 controls Described light source 400 is opened and is irradiated described reagent strip 600;After the first Preset Time, turn off light source 400 and open optics Detector unit 300, the fluorescence sending reagent strip 600 detects and is converted into the signal of telecommunication to process;Preset second Close optical detection unit 300 after time and control described first motor 200 and rotate a step-length;Repeat the above steps is until trying The scanned detection of agent bar 600 is complete.Optical detection unit 300 simple in construction of the present invention, it is not necessary to carry out the light of collimation focusing System, easy to operate, reduce the cost of instrument.
Further, described Time-resolved fluorescence assay system also includes host computer 700, and described host computer 700 is with described Control unit 500 electrically connects.In the present embodiment, host computer 700 is based on ARM platform and Android platform.
Specifically, described optical detection unit 300 includes photoelectric sensor (not shown);Described photoelectric sensor with Described control unit 500 electrically connects;Described host computer 700 according to the data genaration abscissa of photoelectric sensor collection be the time, Vertical coordinate is the curve of light intensity.
Host computer 700 based on ARM platform and Android platform is mutual with user for realizing, and processes slave computer and (i.e. controls Unit 500) fluorescence signal that collects, and it is converted into detection by quantitative result, demonstrate result the most intuitively.
Further, described Time-resolved fluorescence assay system also includes attenuator (not shown);Described optics is examined Surveying unit 300 and be formed with fluorescence detection channel, described attenuator is arranged in fluorescence detection channel.
When incident fluorescence is relatively strong, when exceeding the detection range of photoelectric sensor, need by attenuator, fluorescence to be declined Subtract consumption, meet the input requirements of photoelectric sensor so that fluorescence signal is undistorted, improve the integrity of fluorescence signal.This reality Execute in example.Attenuator uses attenuation quotient to be the attenuator of 0.8.
Further, described Time-resolved fluorescence assay system also includes narrow band pass filter (not shown);Described narrow Band optical filter is arranged in described fluorescence detection channel;The fluorescence that described reagent strip 600 sends by described narrow band pass filter and After described attenuator, detected by described photoelectric sensor.
It should be noted that noise is filtered off by narrow band filter slice, only allow fluorescence to pass through, improve the precision gathering signal, Thus improve certainty of measurement.
Further, described Time-resolved fluorescence assay system also includes the second motor 800, described second motor 800 with Described attenuator is connected by gear mesh;Described control unit 500 controls described second motor 800 step-length and turns to, and drives Attenuator rotates the fluorescence intensity sending described reagent strip 600 and decays.
It should be noted that in order to extend measurement scope, present invention employs the method being automatically adjusted attenuator.When tested Amount fluorescence exceed photoelectric sensor detection range, the attenuator of startup is moved to fluorescence detection channel by the second motor 800 In, incident fluorescence is decayed, to meet the range of photoelectric sensor.
Specifically, described control unit 500 include single-chip microcomputer the 510, first drive circuit the 520, second drive circuit 530, Analog-digital converter 550, filter circuit 560 and light source driving circuit 540;Described single-chip microcomputer 510 drives electricity with described first respectively Road 520, described second drive circuit 530, described analog-digital converter 550, described light source driving circuit 540 and described host computer 700 electrical connections;One end of described filter circuit 560 is connected with described analog-digital converter 550, the other end and described photoelectric sensor Connect;Described first motor 200 is connected with described first drive circuit 520;Described second motor 800 drives electricity with described second Road 530 connects.
Wherein, first drive circuit the 520, second drive circuit 530 and light source driving circuit 540 are for single-chip microcomputer 510 The control signal of output is amplified, to drive first motor the 200, second motor 800 and light source 400 to work respectively.
After the fluorescence signal of collection is converted into the signal of telecommunication by photoelectric sensor, filtered circuit 560 is filtered, to get rid of Interference signal;It is converted into digital signal inputting to single-chip microcomputer 510 by analog-digital converter 560 through analogue signal the most again to carry out Process.
In the present embodiment, described light source 400 uses LED to realize.Described first motor 200 and described second motor 800 Motor is all used to realize.
Technical solution of the present invention is made without the optical system of collimation focusing, and simple in construction cost is relatively low;Use simultaneously Attenuator is automatically adjusted fluorescence intensity, extends the measurement scope of Time-resolved fluorescence assay system.
The present invention also proposes a kind of detection device, and this detection device includes Time-resolved fluorescence assay system, and this time divides Distinguish concrete structure reference above-described embodiment of system of fluorescence analysis, owing to this detection device have employed the complete of above-mentioned all embodiments Portion's technical scheme, the most at least has all beneficial effects that the technical scheme of above-described embodiment is brought, at this most one by one Repeat.
The foregoing is only the preferred embodiments of the present invention, not thereby limit the scope of the claims of the present invention, every at this Under the inventive concept of invention, utilize the equivalent structure transformation that description of the invention and accompanying drawing content are made, or directly/indirectly use The technical field relevant at other is included in the scope of patent protection of the present invention.

Claims (10)

1. a Time-resolved fluorescence assay system, it is characterised in that include guide rail, the first motor, optical detection unit, light source And control unit;Described first motor, optical detection unit and light source all electrically connect with described control unit;Wherein,
Described guide rail, is used for placing reagent strip and by reagent strip delivery extremely described optical detection mould under described first motor drives Block is scanned detection;
Described control unit, is used for controlling the unlatching of described light source and is irradiated described reagent strip;Close after the first Preset Time Disconnected light source also opens signal of telecommunication output that the fluorescence that reagent strip sends by optical detection unit detects and be converted into controlling Unit processes;After the second Preset Time, close optical detection unit and control described one step-length of first electric machine rotation; Repeat the above steps is until the scanned detection of reagent strip is complete.
2. Time-resolved fluorescence assay system as claimed in claim 1, it is characterised in that described Time-resolved fluorescence assay system System also includes that host computer unit, described host computer unit electrically connect with described control unit.
3. Time-resolved fluorescence assay system as claimed in claim 2, it is characterised in that described optical detection unit includes light Electric transducer;Described photoelectric sensor is connected with described control unit;The data that described host computer gathers according to photoelectric sensor Generation abscissa be time, vertical coordinate be the curve of light intensity.
4. Time-resolved fluorescence assay system as claimed in claim 3, it is characterised in that described Time-resolved fluorescence assay system System also includes attenuator;Described optical detection unit is formed with fluorescence detection channel, and described attenuator is arranged at fluoroscopic examination and leads to In road.
5. Time-resolved fluorescence assay system as claimed in claim 4, it is characterised in that described Time-resolved fluorescence assay system System also includes narrow band pass filter;Described narrow band pass filter is arranged in described fluorescence detection channel;It is glimmering that described reagent strip sends After light is by described narrow band pass filter and described attenuator, detected by described photoelectric sensor.
6. Time-resolved fluorescence assay system as claimed in claim 5, it is characterised in that described Time-resolved fluorescence assay system System also includes that the second motor, described second motor are connected by gear mesh with described attenuator;Described control unit controls institute State the second motor step-length and turn to, driving described attenuator to rotate the fluorescence intensity that described reagent strip is sent and decay.
7. Time-resolved fluorescence assay system as claimed in claim 6, it is characterised in that described control unit includes monolithic Machine, the first drive circuit, the second drive circuit, analog-digital converter, light source driving circuit and filter circuit;Described single-chip microcomputer is respectively It is electrically connected with described first drive circuit, the second drive circuit, light source driving circuit, described analog-digital converter and described host computer Connect;One end of described filter circuit is connected with described analog-digital converter, and photoelectric sensor described in the other end connects;Described first electricity Machine is connected with described first drive circuit;Described second motor is connected with described second drive circuit;Described light source and described light Source driving circuit connects.
8. Time-resolved fluorescence assay system as claimed in claim 7, it is characterised in that described light source uses LED.
9. Time-resolved fluorescence assay system as claimed in claim 8, it is characterised in that described first motor and described second Motor all uses motor.
10. one kind detection device, it is characterised in that described detection device include as described in claim 1-9 any one time Between resolved fluorometric analyze system.
CN201610166288.9A 2016-03-21 2016-03-21 Time-resolved fluorescence analysis system and detection apparatus Pending CN105866077A (en)

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Cited By (2)

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CN106290286A (en) * 2016-09-20 2017-01-04 广东顺德工业设计研究院(广东顺德创新设计研究院) Time-resolved fluorescence assay system and detection device
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Application publication date: 20160817