CN105853502A - Application of pyrroloquinoline quinine to improvement on internal environment of female reproductive system - Google Patents
Application of pyrroloquinoline quinine to improvement on internal environment of female reproductive system Download PDFInfo
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- CN105853502A CN105853502A CN201610309902.2A CN201610309902A CN105853502A CN 105853502 A CN105853502 A CN 105853502A CN 201610309902 A CN201610309902 A CN 201610309902A CN 105853502 A CN105853502 A CN 105853502A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
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Abstract
Disclosed is application of pyrroloquinoline quinine to improvement on an internal environment of a female reproductive system. The pyrroloquinoline quinine is applied in a form of a compound which is prepared from, by weight, 1-9 parts of pyrroloquinoline quinine, 2-8 parts of artemisinin, 1-8 parts of mint and 3-9 parts of borneol. The application of the pyrroloquinoline quinine to improvement on the internal environment of the female reproductive system has the advantages that the compound consisting of the pyrroloquinoline quinine, the artemisinin, the mint and the borneol is capable of effectively inhibiting harmful bacteria hidden in wrinkles and recesses of a vagina or cervix muscles, guaranteeing reproductive health, delaying menopause, recovering menorrhea, delaying senescence, promoting secretion of hormones, improving ovarian functions, enhancing ovarian reserve capability, increasing body's hormone level, repairing striae gravidarum and rejuvenating, has good treatment effect on various skin inflammations and skin ulcerations and has the advantages of capabilities of repairing inner walls of female vaginae and endometria, no toxic or side effect, no dependency, safety, effectiveness and capability of treating both symptoms and root causes.
Description
Technical field
The present invention relates to the medicine technology field of female reproductive system, especially relate to PQQ application of environment in improving female reproductive system.
Background technology
Along with the development of society, women status in society also steps up, and women pressure experienced is the most increasing, if well pressure can not be discharged self-control, causes endocrinopathy, the symptoms such as aging, facial colour spot, scytitis and exanthemv occurs.And if women does not notes in life, it is easy to make vaginal walls, uterus inwall and ovary impaired, cause vagina self-purification capacity to reduce or lose, the menses that in lyra of vagina, remaining bacteria, toxin, dead skin cells, row are the cleanest year in year out, lower cloudy itch, leukorrhea peculiar smell, turn yellow, stench, vaginal problems recurrence is made, and the up pelvic cavity of bacteriotoxin causes the problems such as pelvic infecton.Thus affect women's health, bring puzzlement in life to it.
Summary of the invention
In order to overcome the problems referred to above, the present invention provides PQQ application of environment in improving female reproductive system to society, repairing vagina inwall, repairing uterus inwall, repair ovary, go the aspect such as peculiar smell, sterilization to have a very good effect, and have no side effect, no dependence, safely and effectively and treat both principal and secondary aspect of disease.
Offer PQQ application of environment in improving female reproductive system is provided, wherein, described PQQ is applied in the form of compositions, and described composition is made up of the medicine of following composition by weight: PQQ 1-9 part, qinghaosu 2-8 part, peppermint 1-8 part, borneol 3-9 part.
As improvement of the present invention, described composition is made up of the medicine of following composition by weight: PQQ 2-8 part, qinghaosu 3-7 part, peppermint 2-7 part, borneol 4-8 part.
As improvement of the present invention, described composition is made up of the medicine of following composition by weight: PQQ 3-7 part, qinghaosu 4-6 part, peppermint 3-6 part, borneol 5-7 part.
As improvement of the present invention, described composition is made up of the medicine of following composition by weight: PQQ 5 parts, qinghaosu 5 parts, peppermint 4 parts, borneol 6 parts.
As improvement of the present invention, the formulation of described composition includes: tablet, powder agent, capsule, solution, spray or ointment.
As improvement of the present invention, described PQQ is made by pure natural.
Present invention employs PQQ, qinghaosu, peppermint and described borneol; staphylococcus aureus, mould, Pseudomonas aeruginosa, Escherichia coli, Candida albicans etc. there is relatively high inhibition effect; go deep into vagina fully to melt; can effectively suppress the harmful bacteria being hidden in vagina, cervix uteri wall fold crypts; anti-inflammation; promote regeneration, moisten and repair the impaired skin of vagina, protect healthy reproduction；Postpone the menopause time limit, recover menorrhea, delay senility, promote hormone secretion；Improve ovarian function, improve ovarian reserve ability, promote follicular development and ovulation, delay premature ovarian failure, increasing hormone in vivo level, repair striae of pregnancy, retain youth appearance, postpones involutional arrival, regulation internal system balance, stablizes organismic internal environment, improves body's immunity；Various scytitises and exanthemv are had result for the treatment of well, have repair vagina inwall, repair uterus inwall, repair impaired ovary, treatment scytitis, treatment exanthemv, have no side effect, no dependence, safely, effectively and the advantage treated both principal and secondary aspect of disease.
Detailed description of the invention
One, based on years of researches, researcher finds that PQQ environment in improving female reproductive system has good using value; therefore the present invention needs to be protected is PQQ application of environment in improving female reproductive system; wherein; described PQQ is applied in the form of compositions, and described composition is made up of the medicine of following composition by weight: PQQ 1-9 part, qinghaosu 2-8 part, peppermint 1-8 part, borneol 3-9 part.
In the present invention, the formulation of described composition includes: tablet, powder agent, capsule, solution, spray or ointment, and described PQQ is made by pure natural.
In the present invention, the preparation method of described composition, comprise the steps:
(100) peppermint of 1-8 part (composition by weight), is taken:
(200), peppermint is soaked the scheduled time, then the peppermint after soaking is decocted, after decocting certain time, obtain raw material liquid；
(300), raw material liquid is carried out high speed centrifugation process, go the removal of impurity, obtain liquid；
(400), PQQ 1-9 part (composition by weight), qinghaosu 2-8 part (composition by weight) and borneol 3-9 part (composition by weight) are joined liquid obtains be mixed to get described composition；
(500), described composition carried out sterilizing and filter.
In the present invention, also including below embodiment, following example are used for illustrating the present invention, but are not limited to the scope of the present invention.
Embodiment 1
First, the peppermint of 1 part (composition by weight) is taken:
Secondly, peppermint is soaked the scheduled time, then the peppermint after soaking is decocted, after decocting certain time, obtain raw material liquid；Raw material liquid is carried out high speed centrifugation process, goes the removal of impurity, obtain liquid；Then PQQ 1 part (composition by weight), qinghaosu 2 parts (composition by weight) and borneol 3 parts (composition by weight) are joined and obtain in liquid being mixed to get described composition；Finally described composition carried out sterilizing and filter.
Embodiment 2
First, the peppermint of 2 parts (composition by weight) is taken:
Secondly, peppermint is soaked the scheduled time, then the peppermint after soaking is decocted, after decocting certain time, obtain raw material liquid；Raw material liquid is carried out high speed centrifugation process, goes the removal of impurity, obtain liquid；Then PQQ 2 parts (composition by weight), qinghaosu 3 parts (composition by weight) and borneol 4 parts (composition by weight) are joined and obtain in liquid being mixed to get described composition；Finally described composition carried out sterilizing and filter.
Embodiment 3
First, the peppermint of 3 parts (composition by weight) is taken:
Secondly, peppermint is soaked the scheduled time, then the peppermint after soaking is decocted, after decocting certain time, obtain raw material liquid；Raw material liquid is carried out high speed centrifugation process, goes the removal of impurity, obtain liquid；Then PQQ 3 parts (composition by weight), qinghaosu 4 parts (composition by weight) and borneol 5 parts (composition by weight) are joined and obtain in liquid being mixed to get described composition；Finally described composition carried out sterilizing and filter.
Embodiment 4
First, the peppermint of 3.4 parts (composition by weight) is taken:
Secondly, peppermint is soaked the scheduled time, then the peppermint after soaking is decocted, after decocting certain time, obtain raw material liquid；Raw material liquid is carried out high speed centrifugation process, goes the removal of impurity, obtain liquid；Then PQQ 4 parts (composition by weight), qinghaosu 4.6 parts (composition by weight) and borneol 5.4 parts (composition by weight) are joined and obtain in liquid being mixed to get described composition；Finally described composition carried out sterilizing and filter.
Embodiment 5
First, the peppermint of 4 parts (composition by weight) is taken:
Secondly, peppermint is soaked the scheduled time, then the peppermint after soaking is decocted, after decocting certain time, obtain raw material liquid；Raw material liquid is carried out high speed centrifugation process, goes the removal of impurity, obtain liquid；Then PQQ 5 parts (composition by weight), qinghaosu 5 parts (composition by weight) and borneol 6 parts (composition by weight) are joined and obtain in liquid being mixed to get described composition；Finally described composition carried out sterilizing and filter.
Embodiment 6
First, the peppermint of 5 parts (composition by weight) is taken:
Secondly, peppermint is soaked the scheduled time, then the peppermint after soaking is decocted, after decocting certain time, obtain raw material liquid；Raw material liquid is carried out high speed centrifugation process, goes the removal of impurity, obtain liquid；Then PQQ 6 parts (composition by weight), qinghaosu 5.4 parts (composition by weight) and borneol 6.4 parts (composition by weight) are joined and obtain in liquid being mixed to get described composition；Finally described composition carried out sterilizing and filter.
Embodiment 7
First, the peppermint of 6 parts (composition by weight) is taken:
Secondly, peppermint is soaked the scheduled time, then the peppermint after soaking is decocted, after decocting certain time, obtain raw material liquid；Raw material liquid is carried out high speed centrifugation process, goes the removal of impurity, obtain liquid；Then PQQ 7 parts (composition by weight), qinghaosu 6 parts (composition by weight) and borneol 7 parts (composition by weight) are joined and obtain in liquid being mixed to get described composition；Finally described composition carried out sterilizing and filter.
Embodiment 8
First, the peppermint of 7 parts (composition by weight) is taken:
Secondly, peppermint is soaked the scheduled time, then the peppermint after soaking is decocted, after decocting certain time, obtain raw material liquid；Raw material liquid is carried out high speed centrifugation process, goes the removal of impurity, obtain liquid；Then PQQ 8 parts (composition by weight), qinghaosu 7 parts (composition by weight) and borneol 8 parts (composition by weight) are joined and obtain in liquid being mixed to get described composition；Finally described composition carried out sterilizing and filter.
Embodiment 9
First, the peppermint of 8 parts (composition by weight) is taken:
Secondly, peppermint is soaked the scheduled time, then the peppermint after soaking is decocted, after decocting certain time, obtain raw material liquid；Raw material liquid is carried out high speed centrifugation process, goes the removal of impurity, obtain liquid；Then PQQ 9 parts (composition by weight), qinghaosu 8 parts (composition by weight) and borneol 9 parts (composition by weight) are joined and obtain in liquid being mixed to get described composition；Finally described composition carried out sterilizing and filter.
Two, below by clinical data, PQQ application of environment in improving female reproductive system being described, wherein, described PQQ is applied with the form of described composition:
1, clinical observation: the described composition in the present invention is since 2010 to 2015 years hospitals throughout the country carry out Clinical practice, collecting patient 800 example altogether, including leukorrhea peculiar smell, lower cloudy itch, vagina inwall is impaired, uterus inwall is impaired, ovary is impaired, ulcus vulvae and vaginitis.
2, instructions of taking: include for oral administration and external application, for oral administration: 12g every time, every bu morning, noon and afternoon are administered orally for 3 times, and warm water is sent down, and taking continuously 30 days is a course for the treatment of.External application: be used for cleaning affected part or being coated in affected part, every day 2 times, 20 days is a course for the treatment of.
3, points for attention:
(1), quit smoking, acne swashs food.
(2), there is inflammatory reaction in local in therapeutic process, drug withdrawal immediately, and symptomatic treatment.
(3), pregnant woman be cautious use of, be continuing with after menstrual period.
4, efficacy result:
The healing ultrahigh in efficiency of the present invention as can be seen from the table, cure rate reaches 86%, and recovery from illness refers to that symptom all disappears.Improvement rate reaches 12%, takes a turn for the better and refers to that symptom take a favorable turn or symptom is obviously improved.Inefficiency only has 2 %, invalid refers to that symptom is not improved, thus it is known that described composition evident in efficacy and without any side effects.
5, some cases data:
Case 1: model, female, 22 years old, is reading student, owing to, during official holiday, employing unholiness sanitary napkin, cause lower cloudy itch, leukorrhea peculiar smell, turn yellow, stench, have a strong impact on its study, multi-treatment is invalid, after 2 courses for the treatment of of for oral administration and heretofore described composition of external application, and complete recovery of health.
Case 2: Zhang, female, 28 years old, evening show worker, vaginal walls is impaired, causes vagina self-purification capacity to reduce or loses, the menses that in lyra of vagina, remaining bacteria, toxin, dead skin cells, row are the cleanest year in year out, vaginal problems recurrence is made, the up pelvic cavity of bacteriotoxin, causes the problems such as pelvic infecton, after 4 courses for the treatment of of for oral administration and heretofore described composition of external application, complete recovery of health, does not the most recur.
Case 3: Jiang, female is 32 years old, married, just spontaneous labor, cause vagina surrounding muscle tear during childbirth, when carrying out vagina and cutting suture operation, fail intactly to sew up musculature comprehensively, introitus lax contraction greatly is caused to decline, after 3 courses for the treatment of of for oral administration and heretofore described composition of external application, vagina elastic fibers and band pleat return to normal state, thoroughly improve the loose symptom of its vagina.
Case 4: Huang, female, 25 years old, company's white collar, the repeatedly stream of people so that it is vaginal walls is impaired, affect its love life, after 4 courses for the treatment of of for oral administration and heretofore described composition of external application, vaginal walls is repaired, and love life is smooth and easy.
Case 5: Wu, female, 30 years old, vaginal walls was impaired, caused bacterium to infect and a series of inflammation, after 3 courses for the treatment of of for oral administration and heretofore described composition of external application, vaginal walls is repaired, and makes its vagina clean, removes free radical, reduce melanin to generate, make that its skin is ruddy, whitening, health.
Case 6: Wang, female, 35 years old, company clerk, suffers from gynaecological imflammation for a long time, such as symptoms such as women vaginitis, vulvitis, eczema genitalium, ulcus vulvae, women abnormal leucorrheas, multi-treatment is invalid, after 5 courses for the treatment of of for oral administration and heretofore described composition of external application, gynaecological imflammation disappears, and has recovered health.
Case 7: Lee, female, 30 years old, repeatedly carry out the stream of people, uterus inwall is badly damaged, and causes Hypomenorrhea, after marriage, for a long time cannot be conceived, after 8 courses for the treatment of of heretofore described composition for oral administration, uterus inwall is repaired, through pregnancy.
Case 8: Zhang, female, 26 years old, not long ago having done ectopic pregnancy operation, result has been spent one month and has been found to also have in uterus hemostasis, is staying always, do the most again a palace of the Qing Dynasty operation, now due to operation is frequently, causing ovary impaired, present people starts skin wrinkle, start symptoms such as losing hair, after 6 courses for the treatment of of heretofore described composition for oral administration, ovary is repaired, and above-mentioned symptom disappears.
Present invention employs described PQQ, described qinghaosu, described peppermint and described borneol; staphylococcus aureus, mould, Pseudomonas aeruginosa, Escherichia coli, Candida albicans etc. there is relatively high inhibition effect; go deep into vagina fully to melt; can effectively suppress the harmful bacteria being hidden in vagina, cervix uteri wall fold crypts; anti-inflammation; promote regeneration, moisten and repair the impaired skin of vagina, protect healthy reproduction；Postpone the menopause time limit, recover menorrhea, delay senility, promote hormone secretion；Improve ovarian function, improve ovarian reserve ability, promote follicular development and ovulation, delay premature ovarian failure, increasing hormone in vivo level, repair striae of pregnancy, retain youth appearance, postpones involutional arrival, regulation internal system balance, stablizes organismic internal environment, improves body's immunity；Various scytitises and exanthemv are had result for the treatment of well, have repair vagina inwall, repair uterus inwall, repair ovary, treatment scytitis, treatment exanthemv, have no side effect, no dependence, safely, effectively and the advantage treated both principal and secondary aspect of disease.
Claims (6)
1. PQQ application of environment in improving female reproductive system, wherein, described PQQ is applied in the form of compositions, and described composition is made up of the medicine of following composition by weight: PQQ 1-9 part, qinghaosu 2-8 part, peppermint 1-8 part, borneol 3-9 part.
Application the most according to claim 1, it is characterised in that: described composition is made up of the medicine of following composition by weight: PQQ 2-8 part, qinghaosu 3-7 part, peppermint 2-7 part, borneol 4-8 part.
Application the most according to claim 1, it is characterised in that: described composition is made up of the medicine of following composition by weight: PQQ 3-7 part, qinghaosu 4-6 part, peppermint 3-6 part, borneol 5-7 part.
Application the most according to claim 1, it is characterised in that: described composition is made up of the medicine of following composition by weight: PQQ 5 parts, qinghaosu 5 parts, peppermint 4 parts, borneol 6 parts.
5. according to the application described in any one claim in claim 1-4, it is characterised in that: the formulation of described composition includes: tablet, powder agent, capsule, solution, spray or ointment.
6. according to the application described in any one claim in claim 1-4, it is characterised in that: described PQQ is made by pure natural.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201610309902.2A CN105853502A (en) | 2016-05-11 | 2016-05-11 | Application of pyrroloquinoline quinine to improvement on internal environment of female reproductive system |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610309902.2A CN105853502A (en) | 2016-05-11 | 2016-05-11 | Application of pyrroloquinoline quinine to improvement on internal environment of female reproductive system |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113813261A (en) * | 2021-09-15 | 2021-12-21 | 常州市妇幼保健院 | Application of pyrroloquinoline quinone in preventing and/or treating female reproductive dysfunction |
| CN114007618A (en) * | 2019-06-28 | 2022-02-01 | 国立大学法人广岛大学 | Female anti-aging agent |
| WO2022166599A1 (en) * | 2021-02-02 | 2022-08-11 | 广州沪同有梧生物科技有限公司 | New use of pqq and derivative thereof |
| WO2024245461A1 (en) * | 2023-07-24 | 2024-12-05 | 广州沪同有梧生物科技有限公司 | Use of pqq in preparation of modulator for menstrual cycle disorders |
| WO2025002115A1 (en) * | 2023-06-28 | 2025-01-02 | 南京纽邦生物科技有限公司 | Method and composition for protecting or improving ovarian function in mammals |
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| CN1602858A (en) * | 2003-09-30 | 2005-04-06 | 昆明紫健生物技术有限公司 | Arteannuin preparation for treating gynecopathy |
| CN101829130A (en) * | 2009-03-09 | 2010-09-15 | 中国人民武装警察部队医学院 | Compound resveratrol anti-inflammatory and itching relieving medicament combination and purpose thereof |
| CN104856996A (en) * | 2015-04-27 | 2015-08-26 | 南京舒鹏生物科技有限公司 | Pyrroloquinoline quinine, novel medicine applications of derivative and/or salt of pyrroloquinoline quinine and medicine composition |
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Patent Citations (3)
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| CN1602858A (en) * | 2003-09-30 | 2005-04-06 | 昆明紫健生物技术有限公司 | Arteannuin preparation for treating gynecopathy |
| CN101829130A (en) * | 2009-03-09 | 2010-09-15 | 中国人民武装警察部队医学院 | Compound resveratrol anti-inflammatory and itching relieving medicament combination and purpose thereof |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114007618A (en) * | 2019-06-28 | 2022-02-01 | 国立大学法人广岛大学 | Female anti-aging agent |
| WO2022166599A1 (en) * | 2021-02-02 | 2022-08-11 | 广州沪同有梧生物科技有限公司 | New use of pqq and derivative thereof |
| CN116669732A (en) * | 2021-02-02 | 2023-08-29 | 广州沪同有梧生物科技有限公司 | New applications of PQQ and its derivatives |
| CN113813261A (en) * | 2021-09-15 | 2021-12-21 | 常州市妇幼保健院 | Application of pyrroloquinoline quinone in preventing and/or treating female reproductive dysfunction |
| WO2025002115A1 (en) * | 2023-06-28 | 2025-01-02 | 南京纽邦生物科技有限公司 | Method and composition for protecting or improving ovarian function in mammals |
| WO2024245461A1 (en) * | 2023-07-24 | 2024-12-05 | 广州沪同有梧生物科技有限公司 | Use of pqq in preparation of modulator for menstrual cycle disorders |
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