CN105796961A - Application of dried tangerine peel and lalang grass rhizome composition in preparation of drug resisting vomiting due to chemotherapy - Google Patents
Application of dried tangerine peel and lalang grass rhizome composition in preparation of drug resisting vomiting due to chemotherapy Download PDFInfo
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- CN105796961A CN105796961A CN201610221039.5A CN201610221039A CN105796961A CN 105796961 A CN105796961 A CN 105796961A CN 201610221039 A CN201610221039 A CN 201610221039A CN 105796961 A CN105796961 A CN 105796961A
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- Prior art keywords
- pericarpium citri
- citri reticulatae
- rhizoma imperatae
- preparation
- chemotherapy
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- 239000000203 mixture Substances 0.000 title claims abstract description 34
- 239000003814 drug Substances 0.000 title claims abstract description 31
- 206010047700 Vomiting Diseases 0.000 title claims abstract description 18
- 238000002512 chemotherapy Methods 0.000 title claims abstract description 16
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 241001598107 Imperata Species 0.000 title claims abstract description 10
- 244000025254 Cannabis sativa Species 0.000 title claims abstract description 9
- 229940079593 drug Drugs 0.000 title abstract description 23
- 230000008673 vomiting Effects 0.000 title abstract description 13
- 241000675108 Citrus tangerina Species 0.000 title abstract 6
- 150000004676 glycans Chemical class 0.000 claims abstract description 32
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 30
- 239000005017 polysaccharide Substances 0.000 claims abstract description 30
- 239000000284 extract Substances 0.000 claims abstract description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 23
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 18
- 238000009835 boiling Methods 0.000 claims description 13
- 239000000706 filtrate Substances 0.000 claims description 9
- 238000001914 filtration Methods 0.000 claims description 9
- 239000012467 final product Substances 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 7
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 6
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 6
- 239000012153 distilled water Substances 0.000 claims description 6
- 229960004756 ethanol Drugs 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 6
- 238000010992 reflux Methods 0.000 claims description 6
- 230000006837 decompression Effects 0.000 claims description 4
- 239000012141 concentrate Substances 0.000 claims description 3
- 229960000935 dehydrated alcohol Drugs 0.000 claims description 3
- 230000003292 diminished effect Effects 0.000 claims description 3
- 238000000605 extraction Methods 0.000 claims description 3
- 238000007654 immersion Methods 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 239000002244 precipitate Substances 0.000 claims description 3
- 238000001556 precipitation Methods 0.000 claims description 3
- 238000000108 ultra-filtration Methods 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 22
- 201000011510 cancer Diseases 0.000 abstract description 8
- 206010028980 Neoplasm Diseases 0.000 abstract description 7
- 241000700159 Rattus Species 0.000 description 9
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 8
- 239000005995 Aluminium silicate Substances 0.000 description 7
- 235000012211 aluminium silicate Nutrition 0.000 description 7
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 description 5
- 229960004316 cisplatin Drugs 0.000 description 5
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 description 4
- 238000011160 research Methods 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- FELGMEQIXOGIFQ-CYBMUJFWSA-N (3r)-9-methyl-3-[(2-methylimidazol-1-yl)methyl]-2,3-dihydro-1h-carbazol-4-one Chemical group CC1=NC=CN1C[C@@H]1C(=O)C(C=2C(=CC=CC=2)N2C)=C2CC1 FELGMEQIXOGIFQ-CYBMUJFWSA-N 0.000 description 2
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 2
- 206010023126 Jaundice Diseases 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
- 230000006399 behavior Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 229960003638 dopamine Drugs 0.000 description 2
- 230000000857 drug effect Effects 0.000 description 2
- 208000001780 epistaxis Diseases 0.000 description 2
- 231100000053 low toxicity Toxicity 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 229960005343 ondansetron Drugs 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 150000004804 polysaccharides Polymers 0.000 description 2
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 description 2
- 239000002464 receptor antagonist Substances 0.000 description 2
- MKBLHFILKIKSQM-UHFFFAOYSA-N 9-methyl-3-[(2-methyl-1h-imidazol-3-ium-3-yl)methyl]-2,3-dihydro-1h-carbazol-4-one;chloride Chemical compound Cl.CC1=NC=CN1CC1C(=O)C(C=2C(=CC=CC=2)N2C)=C2CC1 MKBLHFILKIKSQM-UHFFFAOYSA-N 0.000 description 1
- 208000001889 Acid-Base Imbalance Diseases 0.000 description 1
- 208000007848 Alcoholism Diseases 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 241001672694 Citrus reticulata Species 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 208000031361 Hiccup Diseases 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 206010030302 Oliguria Diseases 0.000 description 1
- 241001093501 Rutaceae Species 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 206010043458 Thirst Diseases 0.000 description 1
- 208000037386 Typhoid Diseases 0.000 description 1
- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 description 1
- 229960004373 acetylcholine Drugs 0.000 description 1
- 201000007930 alcohol dependence Diseases 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 230000003474 anti-emetic effect Effects 0.000 description 1
- 230000002238 attenuated effect Effects 0.000 description 1
- 229930003827 cannabinoid Natural products 0.000 description 1
- 239000003557 cannabinoid Substances 0.000 description 1
- 229940065144 cannabinoids Drugs 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 210000002249 digestive system Anatomy 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 239000000890 drug combination Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- NLDDIKRKFXEWBK-AWEZNQCLSA-N gingerol Chemical compound CCCCC[C@H](O)CC(=O)CCC1=CC=C(O)C(OC)=C1 NLDDIKRKFXEWBK-AWEZNQCLSA-N 0.000 description 1
- JZLXEKNVCWMYHI-UHFFFAOYSA-N gingerol Natural products CCCCC(O)CC(=O)CCC1=CC=C(O)C(OC)=C1 JZLXEKNVCWMYHI-UHFFFAOYSA-N 0.000 description 1
- 235000002780 gingerol Nutrition 0.000 description 1
- -1 has histamine (H2) Chemical compound 0.000 description 1
- 208000006750 hematuria Diseases 0.000 description 1
- 229960001340 histamine Drugs 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 229910052622 kaolinite Inorganic materials 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 229940048949 ondansetron 4 mg Drugs 0.000 description 1
- 229960000770 ondansetron hydrochloride Drugs 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000001047 pyretic effect Effects 0.000 description 1
- 208000010540 rapid respiration Diseases 0.000 description 1
- 229940044551 receptor antagonist Drugs 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000003369 serotonin 5-HT3 receptor antagonist Substances 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 201000008297 typhoid fever Diseases 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
- 210000004916 vomit Anatomy 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
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- Engineering & Computer Science (AREA)
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Abstract
The invention relates to an application of dried tangerine peel and lalang grass rhizome composition in preparation of a drug resisting vomiting due to chemotherapy. The composition is prepared from water-decocted and concentrated extract of dried tangerine peel and lalang grass rhizomes, dried tangerine peel polysaccharides and lalang grass rhizome polysaccharides, and a ratio of the water-decocted and concentrated extract of dried tangerine peel and lalang grass rhizomes to dried tangerine peel polysaccharides to lalang grass rhizome polysaccharides is 4:2:1. The composition has a good curative effect on vomiting due to cancer chemotherapy.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition, relate more specifically to a kind of by Pericarpium Citri Reticulatae Rhizoma Imperatae water boiling concentration extract,
The natural drug composition of Pericarpium Citri Reticulatae polysaccharide, Rhizoma imperatae polysaccharides composition, and this natural drug composition prepares minimizing cancer being used for
Purposes in the vomiting medicine that disease chemotherapy causes.
Background technology
Cancer has become a big killer of facing mankind the most, and mortality rate is only second to cardiovascular disease, and in going up year by year
The trend risen.China has 1,800,000 malignant tumor patients every year, and wherein the patient of 2/3 accepts chemotherapy, although have certain curative effect,
But after chemotherapy, major part patient there will be side effect in various degree, and most common of which side effect is the gastrointestinals such as Nausea and vomiting
Road reacts.Vomiting may result in Digestive system and loses in a large number frequently, and water, electrolyte, acid base imbalance make patient agonizing,
Have a strong impact on the life quality of patient, not only influence whether curative effect, even make patient be difficult to stand and therapy discontinued.
At present, clinical conventional Bendectin mainly has histamine (H2), acetylcholine (M) and dopamine (DA) receptor antagonist
With cannabinoids drug etc., but the weak curative effect that these medicines are to vomit duo to chemotherapy, and toxic and side effects is strong, and application is subject to the very day of one's doom
System.Novel Bendectin, such as NK1Receptor antagonist and 5-HT3Receptor antagonist class medicine, although good to vomit duo to chemotherapy antiemetic effect,
But expensive, range is narrow, and toxicity is big, and clinic needs drug combination more.
The research that Chinese medicine is attenuated for cancer chemotherapy, attracts people's attention.It is therefore, a kind of high-efficiency low-toxicity of research and development, cheap,
The easy to spread natural Chinese medicine that can be used for alleviating cancer chemotherapy vomiting side effect becomes clinical problem demanding prompt solution.
Pericarpium Citri Reticulatae, for rutaceae orange (Citrus reticulata Blanco) and the mature peel of variety thereof,
Have another name called Pericarpium Citri tangerinae, there is spleen invigorating and regulate the flow of vital energy, effect of drying dampness to eliminate phlegm, can and in, stomach-QI being unable to descend normally, nausea and vomiting can be controlled.Rhizoma Imperatae is standing grain
Graminaceous plant Herba Imperatae Imperata cylindrica Beauv.var. major(Nees) dry rhizome of C.E.Hubb..Return
Lung, stomach, bladder warp.Spit blood for heat in blood, epistaxis, hematuria, calentura excessive thirst, cough due to lung-heat, gastropyretic vomiting, jaundice due to damp-heat, edema
Oliguria, the puckery pain of pyretic stranguria.Compendium of Material Medica records its effect to be had: the emesis all blood of nosebleed, typhoid fever hiccup, lung-heat dyspnea with rapid respiration, edema jaundice, solves
Alcoholism.The effective ingredient of the two is carried out extracting separation by the present inventor, through research and the experiment of substantial amounts of each formula proportion,
After obtain the optimal drug comparative compositions of the present invention, be the compositions of the novelty agreed with mutually with polyceptor target spot ratio,
And demonstrate its vomiting that cancer chemotherapy is caused and have fabulous curative effect, this completes the present invention.
Summary of the invention
First purpose of the present invention is to provide a kind of natural drug composition, and said composition low toxicity is efficient, determined curative effect,
It is easy to application and promotes, vomit duo to chemotherapy side effect can be resisted.
Second purpose of the present invention is to provide above-mentioned natural drug composition to reduce cancer chemotherapy side effect in preparation
Purposes in medicine.
A kind of natural drug composition that the present invention provides, by Pericarpium Citri Reticulatae Rhizoma Imperatae water boiling concentration extract, Pericarpium Citri Reticulatae polysaccharide, white
Rhizoma Imperatae polysaccharide is formed in the ratio of 4:2:1 by weight.
Wherein, Pericarpium Citri Reticulatae Rhizoma Imperatae water boiling concentration extract, Pericarpium Citri Reticulatae polysaccharide, Rhizoma imperatae polysaccharides can pass through those skilled in the art
Known conventional method carries out purifying acquisition, and Pericarpium Citri Reticulatae polysaccharide is even commercially available, and these of employing conventional method acquisition become
The natural drug of the present invention dividing or using commercially available one-tenth to be grouped into all can obtain identical curative effect.The method being listed below
It is only that inventor thinks preferred method, is not intended to the extracting method of composition each in this natural drug composition is made
Particularly limit.
Preferably, in above-mentioned natural drug composition, the preparation method of Pericarpium Citri Reticulatae Rhizoma Imperatae water boiling concentration extract is:
Being that 1:1 takes Pericarpium Citri Reticulatae, Rhizoma Imperatae, distilled water immersion according to proportion compatibility, heating decocts, and filters, and preserves filtrate, and medicinal residues add again
Distilled water, soaks with method, decoct, filters, and by twice filtrate mixing, heating is concentrated into small size, ultrafiltration membrance filter, and decompression is dry
Dry, to obtain final product.
In above-mentioned natural drug composition, the preparation method of Pericarpium Citri Reticulatae polysaccharide is:
Pericarpium Citri Reticulatae pulverizes and sieves, the alcohol reflux 30min of 80%, sloughs surface fat, sucking filtration, air-dries, the sample after defat, uses
Apparatus,Soxhlet's extracts 2 times, each 30min, by twice lixiviating solution filtration under diminished pressure, removes filtering residue, merges twice filtrate decompression dense
Reduced concentration is reduced to small size, to obtain final product.
In above-mentioned natural drug composition, Rhizoma imperatae polysaccharides preparation method is:
Take lalang grass rhizome, the reflux, extract, that adds water 2 times, filter, united extraction liquid, concentrate, 95% ethanol precipitate with ethanol, stand 24 h,
The precipitation obtained appropriate dehydrated alcohol, ether, acetone wash successively, are dried, to obtain final product.
Natural drug composition of the present invention having the beneficial effect that in terms of resisting emesis:
1, natural drug composition of the present invention has good resisting emesis effect, different addicted to Kaolin rat before having completed clinic
The pharmaceutical research of model.Research shows: this natural drug composition has bright for rat caused by cisplatin is different addicted to Kaolin behavior
Aobvious antagonism, its effect is better than being used alone Pericarpium Citri Reticulatae Rhizoma Imperatae water boiling concentration extract, Pericarpium Citri Reticulatae polysaccharide and Rhizoma imperatae polysaccharides.
2, Pericarpium Citri Reticulatae Rhizoma Imperatae water boiling concentration extract, Pericarpium Citri Reticulatae polysaccharide, Rhizoma imperatae polysaccharides are carried out group by the present inventor originally
Close, and determine the consumption proportion between these components by great many of experiments, make said composition play good synergism, obtain
Obtain unexpected effect.Passing through our experimentation repeatedly, when the usage ratio of each component is 4:2:1, potentiation is obvious, and this is this
A person of good sense pays a large amount of creative work and obtains, and those of ordinary skill in the art cannot simply obtain only by disclosure
Obtain this ratio range and optimum amount ratio.
3, this natural drug composition Pericarpium Citri Reticulatae Rhizoma Imperatae water boiling concentration extract, Pericarpium Citri Reticulatae polysaccharide, each component of Rhizoma imperatae polysaccharides
All can be obtained by conventional means, some of them component such as Pericarpium Citri Reticulatae polysaccharide is also by commercially available, and such compositions is originally
Body has acquisition convenience, lower-cost effect.This be also inventor pass through a large amount of creative work side obtain have concurrently splendid
Curative effect and the product of higher industrial practicality.
Detailed description of the invention
The preparation of of the present invention natural drug composition is expanded on further below by embodiment and test example, and it is anti-
The beneficial effect of vomiting application.
Embodiment
The first step: the preparation of various extracts
(1) preparation of Pericarpium Citri Reticulatae Rhizoma Imperatae water boiling concentration extract
Being that 1:1 takes Pericarpium Citri Reticulatae, Rhizoma Imperatae, distilled water immersion according to proportion compatibility, heating decocts, and filters, and preserves filtrate, and medicinal residues add again
Distilled water, soaks with method, decoct, filters, and by twice filtrate mixing, heating is concentrated into small size, ultrafiltration membrance filter, and decompression is dry
Dry, to obtain final product.
(2) preparation of Pericarpium Citri Reticulatae polysaccharide
Pericarpium Citri Reticulatae pulverizes and sieves, the alcohol reflux 30min of 80%, sloughs surface fat, sucking filtration, air-dries, the sample after defat, uses rope
Family name's extractor extracts 2 times, each 30min, by twice lixiviating solution filtration under diminished pressure, removes filtering residue, merges twice filtrate reduced in volume
It is concentrated into small size, to obtain final product.
(3) preparation of Rhizoma imperatae polysaccharides
Take lalang grass rhizome, the reflux, extract, that adds water 2 times, filter, united extraction liquid, concentrate, 95% ethanol precipitate with ethanol, stand 24 h,
The precipitation obtained appropriate dehydrated alcohol, ether, acetone wash successively, are dried, to obtain final product.
Drug effect and pharmacological data:
In following test example, compositions is: Pericarpium Citri Reticulatae Rhizoma Imperatae water boiling concentration extract, Pericarpium Citri Reticulatae polysaccharide, the use of Rhizoma imperatae polysaccharides
Amount ratio is 4:2:1, conventional means the compositions that prepare or commercially available above-mentioned four kinds of one-tenth are grouped into has with above-mentioned
The identical effect of compositions that method prepares, its experimental data the most no longer enumerates, and this can be approved by those skilled in the art.
The following is the drug effect and pharmacological data preferred embodiment obtained:
Test example 1: the pharmacodynamic study of natural drug composition treatment vomiting effect
1, test material
(1) Kaolin
(2) cisplatin (cisplatin)
(3) Ondansetron Hydrochloride injection
(4) rat, male, ad lib drinking-water before experiment.
2, test method:
Rat being randomly divided into 7 groups, often group 6, A group is blank group, and B group is model control group, and C group is ondansetron group, D group
For Pericarpium Citri Reticulatae Rhizoma Imperatae water boiling concentration extract, E group is Pericarpium Citri Reticulatae polysaccharide group, and F group is Rhizoma imperatae polysaccharides group, and G group is the sky of the present invention
So pharmaceutical composition (Pericarpium Citri Reticulatae Rhizoma Imperatae water boiling concentration extract, Pericarpium Citri Reticulatae polysaccharide, Rhizoma imperatae polysaccharides are mixed in 4:2:1 ratio).A、B
Group is first to give normal saline 5ml kg-1ig；C group give to ondansetron 4mg kg-1Ip pretreatment；D-G group is to phase
The medicine 10g.kg answered-1(being equivalent to containing crude drug amount) ig pretreatment, successive administration thing three days, fasting after being administered for second day.3rd
After it administration 30min in addition to A group, all give cisplatin 3mg kg-1Ip, observes each group of rat different addicted to kaolinite in 6h upon administration
Soil behavior, records rats eating Kaolin amount.
3, experimental result
Comparing with matched group, model group rats feed Kaolin amount substantially increases (P < 0.01).Ondansetron group and the present invention's
Compositions can substantially reduce rats eating Kaolin amount.The results are shown in Table 1.
Table 1 gingerol is at cisplatin (3 mg kg−1, ip) and the different Functional observation addicted to model of the rat (n=6, mg) induced
| Group | Dosage (g/kg) | Kaolin amount (mg) |
| A | 48.0±10.7 | |
| B | 1850.9±155.6 a | |
| C | 0.004 | 421.9±85.7b |
| D | 10a | 1776.1±125.1 |
| E | 10a | 1652.6±248.1 |
| F | 10a | 1744.8±205.1 |
| G | 10a | 812.6±100.8b |
Note: a is equivalent to, containing crude drug amount, compare with matched groupaP < 0.01, compared with model groupbP<0.01。
Claims (2)
1. the Pericarpium Citri Reticulatae Rhizoma Imperatae compositions of an anti-emesis of chemotherapy, it is characterised in that said composition is by Pericarpium Citri Reticulatae Rhizoma Imperatae water boiling concentration
Extract, Pericarpium Citri Reticulatae polysaccharide, Rhizoma imperatae polysaccharides are formed in the ratio of 4:2:1 by weight,
Wherein the preparation method of Pericarpium Citri Reticulatae Rhizoma Imperatae water boiling concentration extract is:
Being that 1:1 takes Pericarpium Citri Reticulatae, Rhizoma Imperatae, distilled water immersion according to proportion compatibility, heating decocts, and filters, and preserves filtrate, and medicinal residues add again
Distilled water, soaks with method, decoct, filters, and by twice filtrate mixing, heating is concentrated into small size, ultrafiltration membrance filter, and decompression is dry
Dry, to obtain final product；
Wherein the preparation method of Pericarpium Citri Reticulatae polysaccharide is:
Pericarpium Citri Reticulatae pulverizes and sieves, the alcohol reflux 30min of 80%, sloughs surface fat, sucking filtration, air-dries, the sample after defat, uses rope
Family name's extractor extracts 2 times, each 30min, by twice lixiviating solution filtration under diminished pressure, removes filtering residue, merges twice filtrate reduced in volume
It is concentrated into small size, to obtain final product；
Wherein the preparation method of Rhizoma imperatae polysaccharides is:
Take lalang grass rhizome, the reflux, extract, that adds water 2 times, filter, united extraction liquid, concentrate, 95% ethanol precipitate with ethanol, stand 24 h,
The precipitation obtained appropriate dehydrated alcohol, ether, acetone wash successively, are dried, to obtain final product.
2. the Pericarpium Citri Reticulatae Rhizoma Imperatae compositions as claimed in claim 1 purposes in preparation reduces emesis of chemotherapy medicine.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110117330A (en) * | 2018-02-05 | 2019-08-13 | 上海绿谷制药有限公司 | A kind of isolated Rhizoma imperatae polysaccharides and application thereof |
| CN111848826A (en) * | 2019-04-27 | 2020-10-30 | 九江学院 | Extraction method and application of cogongrass rhizome polysaccharide |
| JP2021512998A (en) * | 2018-02-05 | 2021-05-20 | シャンハイ、グリーン、バレー、ファーマスーティカル、カンパニー、リミテッドＳｈａｎｇｈａｉ Ｇｒｅｅｎ Ｖａｌｌｅｙ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｃｏ．， Ｌｔｄ． | Isolated white chili polysaccharide and its uses |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104095273A (en) * | 2014-08-07 | 2014-10-15 | 宋晓玲 | Traditional Chinese medicine anti-alcoholism beverage |
| CN104523930A (en) * | 2014-12-30 | 2015-04-22 | 青岛大学 | Tangerine peel and largehead atractylodes rhizome composition for reducing chemotherapy-induced vomiting |
-
2016
- 2016-04-12 CN CN201610221039.5A patent/CN105796961A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104095273A (en) * | 2014-08-07 | 2014-10-15 | 宋晓玲 | Traditional Chinese medicine anti-alcoholism beverage |
| CN104523930A (en) * | 2014-12-30 | 2015-04-22 | 青岛大学 | Tangerine peel and largehead atractylodes rhizome composition for reducing chemotherapy-induced vomiting |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110117330A (en) * | 2018-02-05 | 2019-08-13 | 上海绿谷制药有限公司 | A kind of isolated Rhizoma imperatae polysaccharides and application thereof |
| JP2021512998A (en) * | 2018-02-05 | 2021-05-20 | シャンハイ、グリーン、バレー、ファーマスーティカル、カンパニー、リミテッドＳｈａｎｇｈａｉ Ｇｒｅｅｎ Ｖａｌｌｅｙ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｃｏ．， Ｌｔｄ． | Isolated white chili polysaccharide and its uses |
| CN111848826A (en) * | 2019-04-27 | 2020-10-30 | 九江学院 | Extraction method and application of cogongrass rhizome polysaccharide |
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Application publication date: 20160727 |