CN105796912B - 一种外用于解除乳腺癌化疗反应的中药组合物 - Google Patents
一种外用于解除乳腺癌化疗反应的中药组合物 Download PDFInfo
- Publication number
- CN105796912B CN105796912B CN201610148244.3A CN201610148244A CN105796912B CN 105796912 B CN105796912 B CN 105796912B CN 201610148244 A CN201610148244 A CN 201610148244A CN 105796912 B CN105796912 B CN 105796912B
- Authority
- CN
- China
- Prior art keywords
- relieving
- breast cancer
- chemotherapy
- root
- traditional chinese
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000002512 chemotherapy Methods 0.000 title claims abstract description 52
- 206010006187 Breast cancer Diseases 0.000 title claims abstract description 27
- 208000026310 Breast neoplasm Diseases 0.000 title claims abstract description 27
- 239000000203 mixture Substances 0.000 title claims abstract description 27
- 238000006243 chemical reaction Methods 0.000 title claims abstract description 21
- 230000000699 topical effect Effects 0.000 title description 3
- 239000003814 drug Substances 0.000 claims abstract description 47
- 229940079593 drug Drugs 0.000 claims abstract description 16
- 239000002994 raw material Substances 0.000 claims abstract description 12
- 235000006140 Raphanus sativus var sativus Nutrition 0.000 claims abstract description 11
- 244000234609 Portulaca oleracea Species 0.000 claims abstract description 10
- 235000001855 Portulaca oleracea Nutrition 0.000 claims abstract description 10
- 241000218989 Trichosanthes Species 0.000 claims abstract description 10
- 235000001759 Citrus maxima Nutrition 0.000 claims abstract description 9
- 244000276331 Citrus maxima Species 0.000 claims abstract description 9
- 241001523681 Dendrobium Species 0.000 claims abstract description 9
- 241000972672 Phellodendron Species 0.000 claims abstract description 9
- 241000767840 Semiaquilegia Species 0.000 claims abstract description 9
- 241001522129 Pinellia Species 0.000 claims abstract description 6
- 244000273928 Zingiber officinale Species 0.000 claims abstract description 6
- 235000006886 Zingiber officinale Nutrition 0.000 claims abstract description 6
- 235000008397 ginger Nutrition 0.000 claims abstract description 6
- 244000088415 Raphanus sativus Species 0.000 claims abstract 3
- 244000248557 Ophiopogon japonicus Species 0.000 claims description 9
- 229930195210 Ophiopogon Natural products 0.000 claims description 6
- 241001522232 Pinellia ternata Species 0.000 claims description 4
- 230000000694 effects Effects 0.000 abstract description 33
- 206010047700 Vomiting Diseases 0.000 abstract description 13
- 230000006870 function Effects 0.000 abstract description 13
- 210000002784 stomach Anatomy 0.000 abstract description 12
- 239000008280 blood Substances 0.000 abstract description 11
- 210000004369 blood Anatomy 0.000 abstract description 11
- 231100000331 toxic Toxicity 0.000 abstract description 10
- 230000002588 toxic effect Effects 0.000 abstract description 10
- 230000008673 vomiting Effects 0.000 abstract description 10
- 210000000952 spleen Anatomy 0.000 abstract description 9
- 208000002193 Pain Diseases 0.000 abstract description 5
- 230000002411 adverse Effects 0.000 abstract description 5
- 230000029087 digestion Effects 0.000 abstract description 5
- 238000004519 manufacturing process Methods 0.000 abstract description 5
- 239000000843 powder Substances 0.000 abstract description 5
- 230000001737 promoting effect Effects 0.000 abstract description 5
- 206010000060 Abdominal distension Diseases 0.000 abstract description 4
- 206010020601 Hyperchlorhydria Diseases 0.000 abstract description 4
- 210000001124 body fluid Anatomy 0.000 abstract description 4
- 239000010839 body fluid Substances 0.000 abstract description 4
- 239000000463 material Substances 0.000 abstract description 4
- 238000005728 strengthening Methods 0.000 abstract description 4
- 230000002045 lasting effect Effects 0.000 abstract description 3
- 230000001105 regulatory effect Effects 0.000 abstract description 3
- 238000010792 warming Methods 0.000 abstract description 3
- 240000002948 Ophiopogon intermedius Species 0.000 abstract 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 12
- 208000026435 phlegm Diseases 0.000 description 12
- 230000010415 tropism Effects 0.000 description 12
- 235000013305 food Nutrition 0.000 description 11
- 235000005911 diet Nutrition 0.000 description 10
- 230000037213 diet Effects 0.000 description 9
- 241000220259 Raphanus Species 0.000 description 8
- 210000004072 lung Anatomy 0.000 description 8
- 238000000034 method Methods 0.000 description 8
- 206010011224 Cough Diseases 0.000 description 7
- 201000010099 disease Diseases 0.000 description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
- 206010028980 Neoplasm Diseases 0.000 description 6
- 210000004185 liver Anatomy 0.000 description 6
- 206010028813 Nausea Diseases 0.000 description 5
- 238000011156 evaluation Methods 0.000 description 5
- 210000003734 kidney Anatomy 0.000 description 5
- 230000008693 nausea Effects 0.000 description 5
- 201000009030 Carcinoma Diseases 0.000 description 4
- 206010012735 Diarrhoea Diseases 0.000 description 4
- 235000009508 confectionery Nutrition 0.000 description 4
- 239000012530 fluid Substances 0.000 description 4
- 208000001297 phlebitis Diseases 0.000 description 4
- 210000001185 bone marrow Anatomy 0.000 description 3
- 201000011510 cancer Diseases 0.000 description 3
- 208000001848 dysentery Diseases 0.000 description 3
- 235000013399 edible fruits Nutrition 0.000 description 3
- 208000035861 hematochezia Diseases 0.000 description 3
- 241000411851 herbal medicine Species 0.000 description 3
- 210000002429 large intestine Anatomy 0.000 description 3
- 235000014347 soups Nutrition 0.000 description 3
- 238000010025 steaming Methods 0.000 description 3
- 230000008961 swelling Effects 0.000 description 3
- 210000001113 umbilicus Anatomy 0.000 description 3
- 208000004998 Abdominal Pain Diseases 0.000 description 2
- 206010067484 Adverse reaction Diseases 0.000 description 2
- 240000007124 Brassica oleracea Species 0.000 description 2
- 235000003899 Brassica oleracea var acephala Nutrition 0.000 description 2
- 235000011301 Brassica oleracea var capitata Nutrition 0.000 description 2
- 235000001169 Brassica oleracea var oleracea Nutrition 0.000 description 2
- 206010007247 Carbuncle Diseases 0.000 description 2
- 206010010774 Constipation Diseases 0.000 description 2
- 241000371652 Curvularia clavata Species 0.000 description 2
- 201000004624 Dermatitis Diseases 0.000 description 2
- 208000000059 Dyspnea Diseases 0.000 description 2
- 206010013975 Dyspnoeas Diseases 0.000 description 2
- 208000012671 Gastrointestinal haemorrhages Diseases 0.000 description 2
- 208000003251 Pruritus Diseases 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 2
- 206010067171 Regurgitation Diseases 0.000 description 2
- 208000004078 Snake Bites Diseases 0.000 description 2
- 208000031971 Yin Deficiency Diseases 0.000 description 2
- 208000019790 abdominal distention Diseases 0.000 description 2
- 206010000269 abscess Diseases 0.000 description 2
- 230000006838 adverse reaction Effects 0.000 description 2
- 208000022531 anorexia Diseases 0.000 description 2
- 230000001093 anti-cancer Effects 0.000 description 2
- 208000010668 atopic eczema Diseases 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 210000000481 breast Anatomy 0.000 description 2
- 210000000038 chest Anatomy 0.000 description 2
- 206010061428 decreased appetite Diseases 0.000 description 2
- 206010012601 diabetes mellitus Diseases 0.000 description 2
- 208000002173 dizziness Diseases 0.000 description 2
- 208000017574 dry cough Diseases 0.000 description 2
- 201000006549 dyspepsia Diseases 0.000 description 2
- 235000013601 eggs Nutrition 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- 210000002216 heart Anatomy 0.000 description 2
- 238000001990 intravenous administration Methods 0.000 description 2
- 235000020997 lean meat Nutrition 0.000 description 2
- 201000007227 lymph node tuberculosis Diseases 0.000 description 2
- 230000036565 night sweats Effects 0.000 description 2
- 206010029410 night sweats Diseases 0.000 description 2
- 230000024121 nodulation Effects 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 230000001575 pathological effect Effects 0.000 description 2
- 230000007170 pathology Effects 0.000 description 2
- 206010036067 polydipsia Diseases 0.000 description 2
- 235000021395 porridge Nutrition 0.000 description 2
- 230000002980 postoperative effect Effects 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 235000013311 vegetables Nutrition 0.000 description 2
- 206010000077 Abdominal mass Diseases 0.000 description 1
- 206010000087 Abdominal pain upper Diseases 0.000 description 1
- 235000009436 Actinidia deliciosa Nutrition 0.000 description 1
- 244000298697 Actinidia deliciosa Species 0.000 description 1
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 1
- 244000291564 Allium cepa Species 0.000 description 1
- 235000010167 Allium cepa var aggregatum Nutrition 0.000 description 1
- 201000004384 Alopecia Diseases 0.000 description 1
- 241000272525 Anas platyrhynchos Species 0.000 description 1
- 241000272814 Anser sp. Species 0.000 description 1
- 241000512259 Ascophyllum nodosum Species 0.000 description 1
- 244000003416 Asparagus officinalis Species 0.000 description 1
- 235000005340 Asparagus officinalis Nutrition 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical class [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 1
- 241001107116 Castanospermum australe Species 0.000 description 1
- 208000010445 Chilblains Diseases 0.000 description 1
- 241000209020 Cornus Species 0.000 description 1
- 240000008067 Cucumis sativus Species 0.000 description 1
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 description 1
- 244000000626 Daucus carota Species 0.000 description 1
- 235000002767 Daucus carota Nutrition 0.000 description 1
- 240000004638 Dendrobium nobile Species 0.000 description 1
- 201000000297 Erysipelas Diseases 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 206010016807 Fluid retention Diseases 0.000 description 1
- 235000016623 Fragaria vesca Nutrition 0.000 description 1
- 240000009088 Fragaria x ananassa Species 0.000 description 1
- 235000011363 Fragaria x ananassa Nutrition 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 206010017553 Furuncle Diseases 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 208000018779 Globus Sensation Diseases 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 206010018498 Goitre Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 235000007340 Hordeum vulgare Nutrition 0.000 description 1
- 240000005979 Hordeum vulgare Species 0.000 description 1
- 206010021118 Hypotonia Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000006877 Insect Bites and Stings Diseases 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- 240000007049 Juglans regia Species 0.000 description 1
- 235000009496 Juglans regia Nutrition 0.000 description 1
- 241000408747 Lepomis gibbosus Species 0.000 description 1
- 244000241838 Lycium barbarum Species 0.000 description 1
- 235000015459 Lycium barbarum Nutrition 0.000 description 1
- 235000015468 Lycium chinense Nutrition 0.000 description 1
- 241000220225 Malus Species 0.000 description 1
- 235000011430 Malus pumila Nutrition 0.000 description 1
- 235000015103 Malus silvestris Nutrition 0.000 description 1
- 208000007054 Medullary Carcinoma Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010028034 Mouth ulceration Diseases 0.000 description 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 1
- 244000061176 Nicotiana tabacum Species 0.000 description 1
- 206010059013 Nocturnal emission Diseases 0.000 description 1
- 241000237502 Ostreidae Species 0.000 description 1
- 206010033557 Palpitations Diseases 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 241000972673 Phellodendron amurense Species 0.000 description 1
- 235000014443 Pyrus communis Nutrition 0.000 description 1
- 240000001987 Pyrus communis Species 0.000 description 1
- 206010057071 Rectal tenesmus Diseases 0.000 description 1
- 208000007660 Residual Neoplasm Diseases 0.000 description 1
- 206010038776 Retching Diseases 0.000 description 1
- 244000272264 Saussurea lappa Species 0.000 description 1
- 235000006784 Saussurea lappa Nutrition 0.000 description 1
- 241000270295 Serpentes Species 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 244000062793 Sorghum vulgare Species 0.000 description 1
- 235000009337 Spinacia oleracea Nutrition 0.000 description 1
- 244000300264 Spinacia oleracea Species 0.000 description 1
- 208000033809 Suppuration Diseases 0.000 description 1
- 241000282898 Sus scrofa Species 0.000 description 1
- 206010042674 Swelling Diseases 0.000 description 1
- 241000270666 Testudines Species 0.000 description 1
- 206010053615 Thermal burn Diseases 0.000 description 1
- 206010053476 Traumatic haemorrhage Diseases 0.000 description 1
- 241001125843 Trichiuridae Species 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 241001261506 Undaria pinnatifida Species 0.000 description 1
- 235000009754 Vitis X bourquina Nutrition 0.000 description 1
- 235000012333 Vitis X labruscana Nutrition 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 238000009098 adjuvant therapy Methods 0.000 description 1
- 229940069428 antacid Drugs 0.000 description 1
- 239000003159 antacid agent Substances 0.000 description 1
- 230000001458 anti-acid effect Effects 0.000 description 1
- 230000003474 anti-emetic effect Effects 0.000 description 1
- 239000002111 antiemetic agent Substances 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 229940041181 antineoplastic drug Drugs 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 230000006793 arrhythmia Effects 0.000 description 1
- 206010003119 arrhythmia Diseases 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 235000021279 black bean Nutrition 0.000 description 1
- 235000007215 black sesame Nutrition 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 238000004159 blood analysis Methods 0.000 description 1
- 208000027503 bloody stool Diseases 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 208000013116 chronic cough Diseases 0.000 description 1
- 230000007012 clinical effect Effects 0.000 description 1
- 208000012839 conversion disease Diseases 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 235000019007 dietary guidelines Nutrition 0.000 description 1
- 206010013023 diphtheria Diseases 0.000 description 1
- 235000011869 dried fruits Nutrition 0.000 description 1
- 206010013781 dry mouth Diseases 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 206010016629 fibroma Diseases 0.000 description 1
- 208000017561 flaccidity Diseases 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 235000012631 food intake Nutrition 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 208000007565 gingivitis Diseases 0.000 description 1
- 201000003872 goiter Diseases 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 208000024963 hair loss Diseases 0.000 description 1
- 230000003676 hair loss Effects 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 208000013403 hyperactivity Diseases 0.000 description 1
- 206010020718 hyperplasia Diseases 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 206010073095 invasive ductal breast carcinoma Diseases 0.000 description 1
- 201000010985 invasive ductal carcinoma Diseases 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 235000015263 low fat diet Nutrition 0.000 description 1
- 210000001165 lymph node Anatomy 0.000 description 1
- 210000005075 mammary gland Anatomy 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 208000023356 medullary thyroid gland carcinoma Diseases 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 235000019713 millet Nutrition 0.000 description 1
- 235000020636 oyster Nutrition 0.000 description 1
- 150000004965 peroxy acids Chemical class 0.000 description 1
- 238000011248 postoperative chemotherapy Methods 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 235000020236 pumpkin seed Nutrition 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000008085 renal dysfunction Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000008354 sodium chloride injection Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 235000020238 sunflower seed Nutrition 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000002636 symptomatic treatment Methods 0.000 description 1
- 206010042772 syncope Diseases 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 208000012271 tenesmus Diseases 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 201000004647 tinea pedis Diseases 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 231100000611 venom Toxicity 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 235000020234 walnut Nutrition 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8984—Dendrobium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/285—Aucklandia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
- A61K36/428—Trichosanthes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
- A61K36/8888—Pinellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8968—Ophiopogon (Lilyturf)
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Marine Sciences & Fisheries (AREA)
- Zoology (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
本发明涉及一种外用于解除乳腺癌化疗反应的中药组合物，它是由下列重量配比的原料药物组成的：石斛10g‑20g、黄柏10g‑20g、天葵子15g‑20g、天花粉10g‑20g、马齿苋15g‑20g、莱菔子10g‑15g、麦冬10g‑15g、瓦楞子10g‑15g、姜半夏5g‑10g、木香5g‑10g、化橘红5g‑10g。本发明采用天然的中药原料，研碾成粉末敷脐，具有清热解毒、理气宽中、益胃生津，健脾消食，制酸止痛，软坚散结，温中化瘀，降逆止呕，使用安全，功效持久，其配制简便、药源广、成本低，疗效显著，药性平和，有效率达93.3％。
Description
技术领域
本发明涉及一种传统草药的未确定结构的医用配制品，具体地说是一种外用于解除乳腺癌化疗反应的中药组合物。
背景技术
乳腺癌是女性最常见的恶性肿瘤之一，在我国占全身各系统肿瘤的7-10％，呈逐年上升趋势。手术治疗是乳腺癌的主要治疗方法之一，术后应用化学药物辅助治疗，是实体肿瘤中应用化疗最有效的肿瘤之一，化疗在整个治疗中占有重要地位。由于手术尽量去除了肿瘤负荷，残存的肿瘤细胞易被化学抗癌药物杀灭。也有研究表明，乳腺癌为治疗效果较好的恶性肿瘤之一，综合治疗的存活率较高。尽管化疗的确切疗效已受到充分肯定，然而由于化疗的诸多毒副反应，如胃肠道反应、骨髓抑制、口腔溃疡、脱发、心、肝、肾功能异常等等，一部分患者因而不能耐受而中断治疗。
发明内容
本发明的目的就是为了克服上述现有的技术不足，根据中医理论，通过数年的药物筛选和反复临床验证，提供一种配伍合理，药源广，成本低，疗效显著，无毒副作用的外用于解除乳腺癌化疗反应的中药组合物，其具有清热解毒、理气宽中、益胃生津，健脾消食，制酸止痛，软坚散结，温中化瘀，降逆止呕，使用安全，功效持久，使患者顺利渡过化疗期，达到扶正祛邪，平衡阴阳，标本兼治。
本发明解决其技术问题所采用的技术方案是：一种外用于解除乳腺癌化疗反应的中药组合物，其特征在于它是由下列重量配比的原料药物组成的：石斛10g-20g、黄柏10g-20g、天葵子15g-20g、天花粉10g-20g、马齿苋15g-20g、莱菔子10g-15g、麦冬10g-15g、瓦楞子10g-15g、姜半夏5g-10g、木香5g-10g、化橘红5g-10g。
本发明的优选技术方案是：一种外用于解除乳腺癌化疗反应的中药组合物，其特征在于它是由下列重量的原料药物组成的：石斛15g、黄柏15g、天葵子15g、天花粉15g、马齿苋15g、莱菔子12g、麦冬12g、瓦楞子12g、姜半夏9g、木香6g、化橘红6g。
本发明中药组合物是在传统中医理论和临床经验指导下，精选药物组方，原料成本低，应用于解除乳腺癌化疗反应，其疗效高，无毒副作用。本发明中的石斛【性味】微寒；甘【归经】归胃、肾经【功能主治】益胃生津，滋阴清热。用于阴伤津亏，口干烦渴，食少干呕，病后虚热，目暗不明。黄柏【性味】苦，寒【归经】归肾、膀胱经。【功能主治】清热燥湿，泻火除蒸，解毒疗疮。用于湿热泻痢，黄疸，带下，热淋，脚气，痿辟，骨蒸劳热，盗汗，遗精，疮疡肿毒，湿疹瘙痒。盐黄柏滋阴降火。用于阴虚火旺，盗汗骨蒸。天葵子【性味】寒；甘、苦【归经】归肝经【功能主治】清热解毒，消肿散结。用于痈肿疔疮，乳痈，瘰疬，毒蛇咬伤。天花粉【性味】微寒；甘、微苦【归经】归肺、胃经【功能主治】清热生津，消肿排脓。用于热病烦渴，肺热燥咳，内热消渴，疮疡肿毒。马齿苋【性味】寒；酸【归经】归大肠、肝经【功能主治】清热解毒，凉血止血。用于热毒血痢，痈肿疗疮，湿疹，丹毒，蛇虫咬伤，便血，下血。莱菔子【性味】味辛；甘；性平【归经】脾；胃；肺；大肠经【功能主治】消食导滞；降气化痰。主治食积气滞；脘腹胀满；腹泻；下痢后重；咳嗽多痰；气逆喘满。麦冬【性味】微寒；甘、微苦【归经】归心、肺、胃经【功能主治】养阴生津，润肺清心。用于肺燥干咳。虚痨咳嗽，津伤口渴，心烦失眠，内热消渴，肠燥便秘；咽白喉。瓦楞子【性味】味甘；咸；性平【归经】肝；脾；胃经【功能主治】消痰化瘀；软坚散结；制酸止痛。主治瘰疬；瘿瘤；症瘕痞块，顽痰久咳；胃痛吐酸；牙疳；外伤出血；冻疮及烫火伤。姜半夏【性味】辛，温；有毒【归经】归脾、胃、肺经【功能主治】燥湿化痰，降逆止呕，消痞散结。用于痰多咳喘，痰饮眩悸，风痰眩晕，痰厥头痛，呕吐反胃，胸脘痞闷，梅核气；生用外治痈肿痰核。姜半夏多用于降逆止呕。木香【性味】辛、苦，温【归经】归脾、胃、大肠、三焦、胆经【功能主治】行气止痛，健脾消食。用于胸脘胀痛，泻痢后重，食积不消，不思饮食。煨木香实肠止泻。用于泄泻腹痛。化橘红【性味】温；辛、苦【归经】归肺、脾经【功能主治】散寒，燥湿，利气，消痰。用于风寒咳嗽，喉痒痰多，食积伤酒，呕恶痞闷。以上诸药合用，具有清热解毒、理气宽中、益胃生津，健脾消食，制酸止痛，软坚散结，温中化瘀，降逆止呕，使用安全，功效持久，对解除乳腺癌化疗反应达到标本兼治的目的。
本发明组合物遵循中医的处方用药原则，采用天然的中药原料，配制简便、药源广、成本低。将十一味中草药巧妙组方，研碾成粉末敷脐，配合科学的食疗指导可以解除化疗引起的诸多不良反应，使患者顺利渡过化疗期，达到扶正祛邪，平衡阴阳，标本兼治，消除癌细胞赖以生存的环境，经临床应用验证，其疗效显著，作用可靠，药性平和，未出现毒副作用，总有效率93.3％。
具体实施方式
实施例1：一种外用于解除乳腺癌化疗反应的中药组合物，它是由下列重量的原料药物组成的：石斛15g、黄柏15g、天葵子15g、天花粉15g、马齿苋15g、莱菔子12g、麦冬12g、瓦楞子12g、姜半夏9g、木香6g、化橘红6g。
实施例2：一种外用于解除乳腺癌化疗反应的中药组合物，它是由下列重量的原料药物组成的：石斛20g、黄柏20g、天葵子15g、天花粉10g、马齿苋15g、莱菔子10g、麦冬15g、瓦楞子10g、姜半夏5g、木香5g、化橘红10g。
实施例3：一种外用于解除乳腺癌化疗反应的中药组合物，它是由下列重量的原料药物组成的：石斛10gg、黄柏10g、天葵子20g、天花粉20g、马齿苋20g、莱菔子10g、麦冬10g、瓦楞子15g、姜半夏8g、木香10g、化橘红5g。
实施例4：一种外用于解除乳腺癌化疗反应的中药组合物，它是由下列重量的原料药物组成的：石斛12g、黄柏12g、天葵子20g、天花粉20g、马齿苋16g、莱菔子15g、麦冬15g、瓦楞子10g、姜半夏10g、木香6g、化橘红10g。
本发明实施例中的外用于解除乳腺癌化疗反应的中药组合物，具体制备、使用方法如下：将十一味中草药剪碎烘干，碾压成细粉末，过100目筛，装瓶备用。乳腺癌患者化疗前晚上开始用本发明组合物敷脐，洗净擦干患者的脐部，置入备用好的中药组合物10g左右于脐眼及脐周部位，用敷贴固定脐眼药粉部位，每晚换药1次，出汗多时添加1次，至化疗结束后次晨停用。
配合科学的食疗也可有助于解除化疗引起的诸多不良反应，饮食指导：(1)饮食时间：经静脉注射化疗时，指导在化疗前3小时进食，至化疗时，食物已经基本排空消化，化疗结束后3小时进食，化疗前2小时禁食，饭后2小时不平卧。每晚睡觉前，以脐眼为中心，顺时针按揉腹部10-15分钟。口服化疗药物时，饭后半小时服用药物，至血药浓度达到高峰时，胃肠呈空腹状态。巧妙的饮食时间安排，可明显减少恶心、呕吐等胃肠道反应。(2)进食时避免过热、过酸及辛辣、烟、酒刺激性食物，每日清晨1杯淡盐水，急性口腔炎症可口含冰块以减少炎性渗出。静滴化疗药物恶心、呕吐时，可将生姜片含在口中，或者喝鲜姜汁3-5ml，有一定止吐作用。(3)饮食多样化，注意色、香、味、形，以清淡为主，多用蒸、煮、炖的方法。可将小米、黑米、黑豆、黑芝麻、薏米、核桃、枸杞子、葵花籽、南瓜子、燕麦片等熬稀饭或用豆浆机打成稀粥，黑入肾口，凉拌海带、裙带、黄瓜、金针菇、菠菜、白菜、萝卜等，将鸡蛋、瘦肉末、葱切碎加水，少量盐搅拌均匀，用长蒸，或者鸡蛋煮，做汤菜吃，尽量减少油炸、油煎等。(4)适当增加动物骨髓，如牛、羊、猪的骨髓炖汤，冷却后去除上面结的白油，用汤做鸡血、鸭血、鹅血等汤菜。(5)坚持低脂肪饮食，多食富含Vit A、Vit E、Vit C丰富的蔬菜及水果及粗纤维，如胡萝卜、黑木耳、芦笋、包心菜、油菜、猕猴桃、苹果、葡萄、梨、草莓、干果类及带鱼、甲鱼、牡蛎、瘦肉等。避免高脂肪与高热量饮食，多食新鲜蔬菜和水果等含粗纤维较多的食物以预防便秘的发生。
一种外用于解除乳腺癌化疗反应的中药组合物的临床疗效总结：
一、一般性资料：选择2010年3月至2015年11月乳腺癌术后在我院肿瘤科住院化疗患者120例，所有患者均经术后病理确诊为乳腺癌，年龄31-67岁，平均43.5岁，均为女性，单侧发病，病理类型：浸润性导管癌68例，单纯癌31例，髓样癌21例，腋窝淋巴结阳性46例，阴性74例，癌瘤长径≤2cm19例，癌瘤长径＞2cm，≤5cm 92例，癌瘤长径＞5cm 9例根据国际抗癌联盟(UICC)肿瘤分期系统(TNM)分期，其中I期患者29例，II期患者64例，III患者27例。所有病理均排除了乳腺结核、乳腺囊性增生、乳腺纤维瘤等疾患。采用随机数字表法将120例患者分为实验组与对照组各60例。两组患者其年龄、病理类型、肿块大小等经统计处理，P＞0.05，无统计学意义，表明两组患者具有可比性。
二、用法用量：对照组化疗期间采用临床常规止吐抑酸、护肝、保心等药物对症处理，常规普通饮食，并对饮食时间、种类、方法等进行具体指导。
实验组方法：实验组60例患者采用乳腺癌仿根治术50例，乳腺癌根治术10例。实验组60例患者术后化疗开始时间、化疗周期、化疗期间用药及辅助检查等同对照组完全一致，在对照组基础上加用本发明组合物敷脐及饮食指导，并每次化疗后用0.9％氯化钠注射液快速静滴
三、疗效标准：
解除乳腺癌化疗反应疗效评价标准实验组与对照组患者化疗前后均查血常规、肝、肾功能及心电图检查，并观察、记录患者胃肠道反应情况，有否静脉炎发生，按照显效、有效、无效的疗效评价标准进行效果评价。
显效：患者化疗期间无明显恶心、呕吐，可正常进食，化疗周期结束复查血常规：WBC＞4×109/L，HGB＞80g/L，PLT＞50×109/L，心、肝、肾功能正常，无静脉炎发生。
有效：患者化疗期间时有恶心，无明显呕吐，食欲明显下降，进食量减少1/3左右，化疗周期结束复查血常规：WBC≥3×109/L，偶有心律不齐，心律快，心电图大致正常，肝、肾功能正常，偶发静脉炎。
无效：患者化疗期间明显恶心、呕吐，不能进食，化疗周期结束复查血常规：WBC＜3×109/L，并发生静脉炎，给予延长用药间隔时间至停止治疗。
四、治疗效果：
实验组治疗效果：实验组60例患者在常规处理基础上加用本发明组合物及食疗指导，进行四个周期化疗。按照制定的疗效评价标准进行疗效效果评价：显效37例，占61.7％，有效19例，占31.6％，无效4例，占6.7％，患者效率为93.3％。
对照组治疗效果：对照组60例患者按以往临床常规治疗方法，饮食上普通饮食，患者随意无特别指导，进行四周期化疗。按照疗效评价标准进行效果评价：显效28例，占46.7％，有效18例，占30％，无效14例，占23.3％，患者效率为78.3％。
实验组与对照组两组效果比较见下表：
| 组别 | 显效 | 占比％ | 有效 | 占比％ | 无效 | 占比％ |
| 实验组 | 37 | 61.7 | 19 | 31.6 | 4 | 6.7 |
| 对照组 | 28 | 46.7 | 18 | 30 | 14 | 23.3 |
X2＝6.829 P＜0.05
两组治疗效果比较，经统计学处理，P＜0.05，差异显著，有统计学意义。
五、结论：本发明组合物敷脐加科学饮食指导，可明显解除乳腺癌化疗反应的临床症状，使患者顺利渡过化疗期，提高生存率及生命质量，有着较高的临床推广应用价值。
Claims (2)
1.一种外用于解除乳腺癌化疗反应的中药组合物，其特征在于它是由下列重量配比的原料药物组成的：石斛10g-20g、黄柏10g-20g、天葵子15g-20g、天花粉10g-20g、马齿苋15g-20g、莱菔子10g-15g、麦冬10g-15g、瓦楞子10g-15g、姜半夏5g-10g、木香5g-10g、化橘红5g-10g。
2.根据权利要求1所述的一种外用于解除乳腺癌化疗反应的中药组合物，其特征在于它是由下列重量的原料药物组成的：石斛15g、黄柏15g、天葵子15g、天花粉15g、马齿苋15g、莱菔子12g、麦冬12g、瓦楞子12g、姜半夏9g、木香6g、化橘红6g。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610148244.3A CN105796912B (zh) | 2016-03-09 | 2016-03-09 | 一种外用于解除乳腺癌化疗反应的中药组合物 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610148244.3A CN105796912B (zh) | 2016-03-09 | 2016-03-09 | 一种外用于解除乳腺癌化疗反应的中药组合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105796912A CN105796912A (zh) | 2016-07-27 |
| CN105796912B true CN105796912B (zh) | 2019-12-27 |
Family
ID=56467438
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610148244.3A Active CN105796912B (zh) | 2016-03-09 | 2016-03-09 | 一种外用于解除乳腺癌化疗反应的中药组合物 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105796912B (zh) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1679803A (zh) * | 2005-01-25 | 2005-10-12 | 广东怡康制药有限公司 | 改善放化疗后肠胃功能的药物 |
| CN105147989A (zh) * | 2015-10-28 | 2015-12-16 | 青岛华之草医药科技有限公司 | 一种治疗胃肠紊乱的中药组合物及其制备方法 |
-
2016
- 2016-03-09 CN CN201610148244.3A patent/CN105796912B/zh active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1679803A (zh) * | 2005-01-25 | 2005-10-12 | 广东怡康制药有限公司 | 改善放化疗后肠胃功能的药物 |
| CN105147989A (zh) * | 2015-10-28 | 2015-12-16 | 青岛华之草医药科技有限公司 | 一种治疗胃肠紊乱的中药组合物及其制备方法 |
Non-Patent Citations (1)
| Title |
|---|
| 恶性肿瘤化疗后胃肠道反应中医辨证论治分析;杨建生;《湖南中医杂志》;19931231;第9卷(第4期);第9页左栏第1段-右栏最后1段，第10页左栏第1段、右栏最后1段 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105796912A (zh) | 2016-07-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105455047A (zh) | 一种保健鲤鱼丸及其制备方法 | |
| CN104336224A (zh) | 一种辣木茶的加工方法 | |
| CN105796912B (zh) | 一种外用于解除乳腺癌化疗反应的中药组合物 | |
| CN103549449A (zh) | 保健羊肉食品 | |
| CN104605372A (zh) | 一种基于恶性肿瘤放疗患者的营养药膳及制备方法 | |
| CN104256436A (zh) | 一种具有改善肿瘤功能的菌蔬粉条 | |
| CN108939043A (zh) | 一种鲨鱼软骨糖蛋白及其抗癌用途 | |
| CN1935245A (zh) | 一种具有防癌、抗癌作用的营养粉 | |
| CN115399476A (zh) | 一种具有辅助润肠通便功能的食品组合物 | |
| CN104189431A (zh) | 淋巴结核平肝清热制剂及制法 | |
| CN108186921B (zh) | 一种抗肿瘤的含硒中药组合物及其制备方法 | |
| CN104940739A (zh) | 治疗胆道蛔虫症的中药组合物 | |
| CN102423071B (zh) | 食疗包 | |
| CN103535740A (zh) | 保健鸭肉丸 | |
| CN103356830B (zh) | 一种治疗尿毒症的药物及其制备方法 | |
| CN105104980A (zh) | 一种基于恶性肿瘤放疗患者的营养药膳及其制备方法 | |
| CN104381852A (zh) | 黄秋葵、菌、藻植物组合物制作功能性挂面的方法 | |
| KR20250062593A (ko) | 천연재료를 이용한 식품 첨가제 | |
| CN104686668B (zh) | 一种植物蛋白养生乳笋及其制备方法 | |
| KR20250064021A (ko) | 천연재료를 이용한 치약 조성물 | |
| CN103535741A (zh) | 保健鹌鹑肉丸 | |
| CN104547740B (zh) | 一种用于治疗风湿病的中药及其制备方法 | |
| CN112438396A (zh) | 一种食品添加剂及配置方法 | |
| CN103519237A (zh) | 保健水獭肉食品 | |
| CN107693646A (zh) | 一种治疗癫痫的药物及其制备方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |