CN105748728A - 一种治疗皮肤病及乳腺增生的中药组合物及其制备方法 - Google Patents
一种治疗皮肤病及乳腺增生的中药组合物及其制备方法 Download PDFInfo
- Publication number
- CN105748728A CN105748728A CN201610278891.6A CN201610278891A CN105748728A CN 105748728 A CN105748728 A CN 105748728A CN 201610278891 A CN201610278891 A CN 201610278891A CN 105748728 A CN105748728 A CN 105748728A
- Authority
- CN
- China
- Prior art keywords
- radix
- chinese medicine
- medicine composition
- parts
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 113
- 239000003814 drug Substances 0.000 title claims abstract description 101
- 208000017520 skin disease Diseases 0.000 title claims abstract description 52
- 238000002360 preparation method Methods 0.000 title claims abstract description 32
- 210000005075 mammary gland Anatomy 0.000 title abstract description 8
- 206010020718 hyperplasia Diseases 0.000 title abstract description 6
- 241000628997 Flos Species 0.000 claims abstract description 36
- 239000008517 radix Trichosanthis Substances 0.000 claims abstract description 17
- 206010007247 Carbuncle Diseases 0.000 claims abstract description 14
- 201000000297 Erysipelas Diseases 0.000 claims abstract description 8
- 206010063409 Acarodermatitis Diseases 0.000 claims abstract description 6
- 241000447727 Scabies Species 0.000 claims abstract description 6
- 208000005687 scabies Diseases 0.000 claims abstract description 6
- 238000001816 cooling Methods 0.000 claims abstract description 5
- 206010048768 Dermatosis Diseases 0.000 claims description 47
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 18
- 241000717739 Boswellia sacra Species 0.000 claims description 16
- 239000004863 Frankincense Substances 0.000 claims description 16
- 239000000284 extract Substances 0.000 claims description 15
- 241000283956 Manis Species 0.000 claims description 14
- 229940079593 drug Drugs 0.000 claims description 14
- 239000002671 adjuvant Substances 0.000 claims description 13
- 239000002994 raw material Substances 0.000 claims description 12
- 206010040943 Skin Ulcer Diseases 0.000 claims description 11
- 231100000019 skin ulcer Toxicity 0.000 claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 235000019640 taste Nutrition 0.000 claims description 7
- 239000007788 liquid Substances 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 6
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 3
- 238000009835 boiling Methods 0.000 claims description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 3
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 3
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 3
- 239000004744 fabric Substances 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 239000002244 precipitate Substances 0.000 claims description 3
- 238000010992 reflux Methods 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 239000000230 xanthan gum Substances 0.000 claims description 3
- 229920001285 xanthan gum Polymers 0.000 claims description 3
- 229940082509 xanthan gum Drugs 0.000 claims description 3
- 235000010493 xanthan gum Nutrition 0.000 claims description 3
- QIJRTFXNRTXDIP-UHFFFAOYSA-N (1-carboxy-2-sulfanylethyl)azanium;chloride;hydrate Chemical compound O.Cl.SCC(N)C(O)=O QIJRTFXNRTXDIP-UHFFFAOYSA-N 0.000 claims description 2
- KPQJOKRSYYJJEL-VLQRKCJKSA-K [Na+].[Na+].CC1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C([O-])=O)O[C@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O[C@@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)C([O-])=O)C([O-])=O Chemical compound [Na+].[Na+].CC1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C([O-])=O)O[C@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O[C@@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)C([O-])=O)C([O-])=O KPQJOKRSYYJJEL-VLQRKCJKSA-K 0.000 claims description 2
- 239000002775 capsule Substances 0.000 claims description 2
- 229960001305 cysteine hydrochloride Drugs 0.000 claims description 2
- 239000008187 granular material Substances 0.000 claims description 2
- 239000007924 injection Substances 0.000 claims description 2
- 238000002347 injection Methods 0.000 claims description 2
- 239000006187 pill Substances 0.000 claims description 2
- JWYIRZRIDBKTPH-UHFFFAOYSA-N propyl 2-hydroxybenzoate;sodium Chemical compound [Na].CCCOC(=O)C1=CC=CC=C1O JWYIRZRIDBKTPH-UHFFFAOYSA-N 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 23
- 208000002193 Pain Diseases 0.000 abstract description 20
- 230000036407 pain Effects 0.000 abstract description 20
- 239000008280 blood Substances 0.000 abstract description 19
- 210000004369 blood Anatomy 0.000 abstract description 19
- 230000001717 pathogenic effect Effects 0.000 abstract description 6
- 208000033809 Suppuration Diseases 0.000 abstract description 5
- 230000008961 swelling Effects 0.000 abstract description 5
- 206010006187 Breast cancer Diseases 0.000 abstract description 3
- 208000026310 Breast neoplasm Diseases 0.000 abstract description 3
- 230000003213 activating effect Effects 0.000 abstract description 3
- 238000010926 purge Methods 0.000 abstract description 3
- 231100000331 toxic Toxicity 0.000 abstract description 3
- 230000002588 toxic effect Effects 0.000 abstract description 3
- 206010000269 abscess Diseases 0.000 abstract description 2
- 241000382455 Angelica sinensis Species 0.000 abstract 1
- 241000205585 Aquilegia canadensis Species 0.000 abstract 1
- 244000303040 Glycyrrhiza glabra Species 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 235000017443 Hedysarum boreale Nutrition 0.000 abstract 1
- 235000007858 Hedysarum occidentale Nutrition 0.000 abstract 1
- 241000283966 Pholidota <mammal> Species 0.000 abstract 1
- 229920000175 Pistacia lentiscus Polymers 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000003260 anti-sepsis Effects 0.000 abstract 1
- 230000003750 conditioning effect Effects 0.000 abstract 1
- 230000003467 diminishing effect Effects 0.000 abstract 1
- 230000002500 effect on skin Effects 0.000 abstract 1
- 238000009776 industrial production Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000003053 toxin Substances 0.000 abstract 1
- 231100000765 toxin Toxicity 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 30
- 241000700159 Rattus Species 0.000 description 15
- 210000000481 breast Anatomy 0.000 description 14
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 11
- 201000010099 disease Diseases 0.000 description 10
- 231100000614 poison Toxicity 0.000 description 8
- 239000000243 solution Substances 0.000 description 8
- 230000002159 abnormal effect Effects 0.000 description 7
- 210000004185 liver Anatomy 0.000 description 6
- 210000004072 lung Anatomy 0.000 description 6
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 5
- 230000002146 bilateral effect Effects 0.000 description 5
- 230000008859 change Effects 0.000 description 5
- 235000009508 confectionery Nutrition 0.000 description 5
- 238000007796 conventional method Methods 0.000 description 5
- 239000000796 flavoring agent Substances 0.000 description 5
- 235000019634 flavors Nutrition 0.000 description 5
- 208000014674 injury Diseases 0.000 description 5
- 231100001252 long-term toxicity Toxicity 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 210000002784 stomach Anatomy 0.000 description 5
- 230000001225 therapeutic effect Effects 0.000 description 5
- 239000003440 toxic substance Substances 0.000 description 5
- 201000000736 Amenorrhea Diseases 0.000 description 4
- 206010001928 Amenorrhoea Diseases 0.000 description 4
- 206010010774 Constipation Diseases 0.000 description 4
- 241000191023 Rhodobacter capsulatus Species 0.000 description 4
- 208000025865 Ulcer Diseases 0.000 description 4
- 231100000540 amenorrhea Toxicity 0.000 description 4
- 230000000844 anti-bacterial effect Effects 0.000 description 4
- 238000003304 gavage Methods 0.000 description 4
- 210000002216 heart Anatomy 0.000 description 4
- 229920001817 Agar Polymers 0.000 description 3
- 208000006820 Arthralgia Diseases 0.000 description 3
- 206010006298 Breast pain Diseases 0.000 description 3
- 206010017553 Furuncle Diseases 0.000 description 3
- 208000006662 Mastodynia Diseases 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- 206010042674 Swelling Diseases 0.000 description 3
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 3
- 238000011047 acute toxicity test Methods 0.000 description 3
- 239000008272 agar Substances 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 230000003203 everyday effect Effects 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 206010025482 malaise Diseases 0.000 description 3
- 230000002175 menstrual effect Effects 0.000 description 3
- 239000002574 poison Substances 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 238000010791 quenching Methods 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 238000010998 test method Methods 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- 230000035922 thirst Effects 0.000 description 3
- 231100000397 ulcer Toxicity 0.000 description 3
- 206010010904 Convulsion Diseases 0.000 description 2
- 208000005171 Dysmenorrhea Diseases 0.000 description 2
- 206010013935 Dysmenorrhoea Diseases 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 208000015220 Febrile disease Diseases 0.000 description 2
- 206010023126 Jaundice Diseases 0.000 description 2
- 208000019255 Menstrual disease Diseases 0.000 description 2
- 208000025747 Rheumatic disease Diseases 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 210000001015 abdomen Anatomy 0.000 description 2
- 208000019790 abdominal distention Diseases 0.000 description 2
- 230000005856 abnormality Effects 0.000 description 2
- 231100000403 acute toxicity Toxicity 0.000 description 2
- 230000007059 acute toxicity Effects 0.000 description 2
- 230000003385 bacteriostatic effect Effects 0.000 description 2
- 230000033228 biological regulation Effects 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 201000008275 breast carcinoma Diseases 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 230000036461 convulsion Effects 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 230000037213 diet Effects 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 208000002173 dizziness Diseases 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 210000003026 hypopharynx Anatomy 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 231100000957 no side effect Toxicity 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 208000037920 primary disease Diseases 0.000 description 2
- 230000001047 pyretic effect Effects 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 230000000552 rheumatic effect Effects 0.000 description 2
- 230000035943 smell Effects 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 238000007619 statistical method Methods 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 230000008736 traumatic injury Effects 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- 210000001835 viscera Anatomy 0.000 description 2
- 230000008673 vomiting Effects 0.000 description 2
- 238000010792 warming Methods 0.000 description 2
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 206010000077 Abdominal mass Diseases 0.000 description 1
- 206010000087 Abdominal pain upper Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 201000004569 Blindness Diseases 0.000 description 1
- 206010006223 Breast discharge Diseases 0.000 description 1
- 241001164374 Calyx Species 0.000 description 1
- 241000208828 Caprifoliaceae Species 0.000 description 1
- 208000002177 Cataract Diseases 0.000 description 1
- 235000008495 Chrysanthemum leucanthemum Nutrition 0.000 description 1
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 description 1
- 206010010071 Coma Diseases 0.000 description 1
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 1
- 206010010741 Conjunctivitis Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 206010060710 Galactostasis Diseases 0.000 description 1
- 241000533849 Gleditsia Species 0.000 description 1
- 206010018612 Gonorrhoea Diseases 0.000 description 1
- 241000237890 Haliotis Species 0.000 description 1
- 241001489138 Haliotis diversicolor Species 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 208000000616 Hemoptysis Diseases 0.000 description 1
- 208000031361 Hiccup Diseases 0.000 description 1
- 206010024229 Leprosy Diseases 0.000 description 1
- 208000019693 Lung disease Diseases 0.000 description 1
- 241000283967 Manidae Species 0.000 description 1
- 206010062575 Muscle contracture Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 208000001140 Night Blindness Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 241000207834 Oleaceae Species 0.000 description 1
- 206010068319 Oropharyngeal pain Diseases 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 208000008469 Peptic Ulcer Diseases 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- 241000013557 Plantaginaceae Species 0.000 description 1
- 208000005214 Poroma Diseases 0.000 description 1
- 208000033240 Progressive symmetric erythrokeratodermia Diseases 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 208000001431 Psychomotor Agitation Diseases 0.000 description 1
- 208000004680 Rectal Fistula Diseases 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- 206010065954 Stubbornness Diseases 0.000 description 1
- 240000004460 Tanacetum coccineum Species 0.000 description 1
- 206010043376 Tetanus Diseases 0.000 description 1
- 206010053615 Thermal burn Diseases 0.000 description 1
- 206010043458 Thirst Diseases 0.000 description 1
- 208000002474 Tinea Diseases 0.000 description 1
- 241000130764 Tinea Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 206010047513 Vision blurred Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 206010002156 anal fistula Diseases 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 239000003005 anticarcinogenic agent Substances 0.000 description 1
- 208000002399 aphthous stomatitis Diseases 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 230000001174 ascending effect Effects 0.000 description 1
- 206010003549 asthenia Diseases 0.000 description 1
- 230000000680 avirulence Effects 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 208000030270 breast disease Diseases 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 208000006111 contracture Diseases 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 239000003246 corticosteroid Substances 0.000 description 1
- 229960001334 corticosteroids Drugs 0.000 description 1
- 239000012531 culture fluid Substances 0.000 description 1
- 230000002354 daily effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 229940126534 drug product Drugs 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 206010013990 dysuria Diseases 0.000 description 1
- 201000001013 eccrine acrospiroma Diseases 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 208000001780 epistaxis Diseases 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 210000003754 fetus Anatomy 0.000 description 1
- 235000008384 feverfew Nutrition 0.000 description 1
- 206010016629 fibroma Diseases 0.000 description 1
- 230000003325 follicular Effects 0.000 description 1
- -1 found that Substances 0.000 description 1
- 238000002682 general surgery Methods 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 208000001786 gonorrhea Diseases 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 208000035861 hematochezia Diseases 0.000 description 1
- 208000006750 hematuria Diseases 0.000 description 1
- 208000014617 hemorrhoid Diseases 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 210000000629 knee joint Anatomy 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 235000021374 legumes Nutrition 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000002932 luster Substances 0.000 description 1
- 201000007227 lymph node tuberculosis Diseases 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 238000009607 mammography Methods 0.000 description 1
- 208000004396 mastitis Diseases 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 210000002445 nipple Anatomy 0.000 description 1
- 231100000862 numbness Toxicity 0.000 description 1
- 239000006916 nutrient agar Substances 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 229940126701 oral medication Drugs 0.000 description 1
- 230000027758 ovulation cycle Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 208000011906 peptic ulcer disease Diseases 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 208000009146 rhinoscleroma Diseases 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 201000005404 rubella Diseases 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- 230000008359 toxicosis Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 210000004916 vomit Anatomy 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/238—Saposhnikovia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/324—Boswellia, e.g. frankincense
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
- A61K36/428—Trichosanthes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/483—Gleditsia (locust)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/634—Forsythia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/83—Thymelaeaceae (Mezereum family), e.g. leatherwood or false ohelo
- A61K36/835—Aquilaria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Developmental Biology & Embryology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Marine Sciences & Fisheries (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明公开一种治疗皮肤病及乳腺增生的中药组合物及其制备方法,所述中药组合物的由下面主要原料重量份加工制备而成:防风、当归、连翘、沉香、皂刺、甘草、生地、乳香、穿山甲、石决明、天花粉、金银花、大黄和红花。本发明提供的治疗皮肤病及乳腺增生的中药组合物,配方科学合理,各组分协同作用,疗效显著、安全方便且无毒副作用,抗菌、泻火、凉血、清热解毒、排脓、消肿,对丹毒、浓疮、风疮、外痈、疮毒、疥藓等皮肤病效果优异,复发率极低,活血祛瘀,并调理人体对乳腺增生和乳腺癌止痛也有很好的疗效。中药组合物制剂提高了药物的稳定性和生物利用率,本发明提供的治疗皮肤病及乳腺增生的中药组合物制备方法高效,提取有效成分效果好,适合工业生产。
Description
技术领域
本发明属于医药领域,尤其涉及一种治疗皮肤病及乳腺增生的中药组合物及其制备方法。
背景技术
近年来皮肤病的发病率呈明显升高趋势,生活环境、饮食、遗传、免疫功能紊乱、精神刺激、外伤感染等多方面因素导致顽固性皮肤病,如化脓性皮肤病,浓疮、风疮、外痈、疮毒、诸毒,疥藓。而久病多瘀,久医伤身,治疗过程因用药不当导致病情恶化的患者比比皆是,并且很多治疗药物都有一定的副作用。长期使用皮质激素类药物、抗癌药与含有重金属类口服药物,致病情趋向顽固恶化很难治愈。
乳腺增生是指乳腺上皮和纤维组织增生,乳腺组织导管和乳小叶在结构上的退行性病变及进行性结缔组织的生长,是女性最常见的乳房疾病,其发病率占乳腺疾病的首位,近些年来该病发病率呈逐年上升的趋势,年龄也越来越低龄化。
现有治疗皮肤病、乳腺增生的药物见效慢,刺激性大,治疗效果不理想。
因此,开发一种对多种皮肤病以及乳腺增生具有确切治疗效果的中药组合物,将具有重要的意义和价值。
发明内容
针对上述现有技术中存在的问题与缺陷,本发明的目的在于提供一种治疗皮肤病及乳腺增生的中药组合物及其制备方法,该组合物疗效显著、安全方便且无毒副作用,其制备方法高效,提取有效成分效果好,适合工业生产。
本发明是以如下的技术方案实现的:
本发明提供一种治疗皮肤病及乳腺增生的中药组合物,制备所述中药组合物的主要原料重量份组成为:防风5-35份、皂刺10-30份、甘草6-36份、生地10-25份、当归10-45份、连翘5-30份、乳香4-30份、沉香5-35份、穿山甲3-20份、石决明5-25份、天花粉12-45份、金银花5-35份、大黄10-30份,红花10-35份。
优选的,制备所述治疗皮肤病及乳腺增生的中药组合物的主要原料重量份组成为:防风10-25份、皂刺12-20份、甘草10-25份、生地10-20份、当归15-30份、连翘8-20份、乳香5-20份、沉香8-25份、穿山甲3-15份、石决明8-20份、天花粉15-30份、金银花10-30份、大黄12-25份,红花10-25份。
优选的,制备所述治疗皮肤病及乳腺增生的中药组合物的主要原料重量份组成为:防风15份、皂刺15份、甘草15份、生地15份、当归20份、连翘15份、乳香10份、沉香10份、穿山甲5份、石决明10份、天花粉20份、金银花20份、大黄15份,红花12份。
以上组成原料药的重量是以生药计算的,以重量份作为配比,在生产时可按照比例增大或减少,如大规模生产可以以公斤为单位,或以吨为单位,小规模生产也可以以克或毫克为单位,重量可以增大或者减小,但各组成之间的生药材重量配比的比例不变。且以上重量配比的比例是经过科学筛选得到的,可以相应调整组成的量的配比,增加或减少不超过100%,药效不变。
本发明的治疗皮肤病及乳腺增生的中药组合物组方科学合理,其原料药来源如下:
防风:味辛、甘,性微温,功效:祛风解表,胜湿止痛,止痉定搐。主治外感表证,风疹瘙痒,风湿痹痛,破伤风。
皂刺:为豆科植物皂荚的棘刺。辛,温。搜风,拔毒,消肿,排脓。治痈肿,疮毒,疠风,癣疮,胎衣不下。
甘草:为豆科植物甘草的根及根状茎。味甘,性平,入脾、胃、肺经。和中缓急,润肺,解毒,调和诸药,炙用,治脾胃虚弱,食少,腹痛便溏,劳倦发热,肺痿咳嗽,心悸,惊痫;生用,治咽喉肿痛,消化性溃疡,痈疽疮疡,解药毒及食物中毒。
生地:为玄参科植物地黄或怀庆地黄的根茎。性凉,味甘,入心、肝、肾经。既能凉血,又能滋阴,具清热滋阴、凉血止血、生津止渴的功效。
当归:性温,味甘、辛,功能主治:补血活血,调经止痛,润肠通便。用于血虚萎黄、眩晕心悸、月经不调、经闭痛经、虚寒腹痛、肠燥便秘、风湿痹痛、跌扑损伤、痈疽疮疡。
连翘:为木犀科植物连翘的干燥果实。味苦,性微寒,归肺、心、小肠经,清热解毒,消肿散结。用于痈疽,瘰疠,乳痈,丹毒,风热感冒,温病初起,温热入营,高热烦渴,神昏发斑,热淋尿闭。
乳香:辛苦,温,功能主治调气活血,定痛,追毒。治气血凝滞、心腹疼痛,痈疮肿毒,跌打损伤,痛经,产后瘀血刺痛。
沉香:辛、苦,温,功效:降气温中,暖肾纳气。主治气逆喘息,呕吐呃逆,脘腹胀痛,腰膝虚冷,大肠虚秘,小便气淋,男子精冷。
穿山甲:为鲮鲤科动物穿穿山甲鳞甲。性味咸,微寒。归肝、胃经。通经下乳,消肿排脓,搜风通络。用于经闭癓瘕,乳汁不通,痈肿疮毒,关节痹痛,麻木拘挛。
石决明:为鲍科动物杂色鲍、羊鲍、澳洲鲍、耳鲍或白鲍的贝壳。性味咸,寒,归肝经。平肝潜阳,清肝明目。用于头痛眩晕,目赤翳障,视物昏花,青盲雀目。
天花粉:为葫芦科植物栝楼的根。甘苦酸,凉。入肺、胃经。生津,止渴,降火,润燥,排脓,消肿。治热病口渴,消渴,黄疸,肺燥咳血,痈肿,痔瘘。
金银花:为忍冬科植物忍冬、红腺忍冬、山银花(毛萼忍冬)或毛花柱忍的干燥花蕾或带初开的花。性味甘、寒,归肺、心、胃经,清热解毒,凉散风热。用于痈肿疔疮,喉痹,丹毒,热毒血痢,风热感冒,温病发热。
大黄:苦,寒,功效:攻积滞,清湿热,泻火,凉血,祛瘀,解毒。主治:实热便秘,热结胸痞,湿热泻痢,黄疸,淋病,水肿腹满,小便不利,目赤,咽喉肿痛,口舌生疮,胃热呕吐,吐血,咯血,衄血,便血,尿血,蓄血,经闭,产后瘀滞腹痛,症瘕积聚,跌打损伤,热毒痈疡,丹毒,烫伤。
红花:为菊科植物红花的花。辛,温。入心、肝经。活血通经,去瘀止痛。治经闭,症瘕,难产,死胎,产后恶露不行、瘀血作痛,痈肿,跌扑损伤。
作为本发明的进一步改进,本发明提高了一种治疗皮肤病及乳腺增生的中药组合物和辅料制备的制剂,所述制剂包括合剂、片剂、胶囊剂、颗粒剂、注射剂或丸剂,所述中药组合物和辅料的重量比为1:3.5-6。
进一步的,所述制剂为合剂,所述辅料由以下重量份数的成分组成:195-220份的水、40-65份的盐酸半胱氨酸、60-85份的桂皮油、25-35份的对羟基苯甲酸丙酯钠盐、42-60份的甘草酸二钠。
其中,上述辅料可以提高中药组合物在合剂中的溶解度,有利于人体吸收,还改善了味道,起到开胃的作用,同时,提高了合剂的储存时间。
进一步的,所述辅料还包括重量份数为35-47份的黄原胶、25-35份的羧甲基纤维素。
其中,上述辅料提高了合剂的稳定性,是合剂内的成分分布更均匀,提高了储存时间。
进一步的,制备所述制剂所用的中药组合物和辅料的重量份为:
本发明提供了一种治疗皮肤病及乳腺增生的中药组合物的制备方法,所述方法包括如下步骤:
a)称取处方量的防风、当归、连翘和沉香4味原料药加水煎煮2次,第一次15倍水量煎煮4h,第二次10倍水量煎煮2h,合并得煎液,温度50℃条件下浓缩成相对密度为1.2g/ml,冷却,加75%的乙醇进行醇沉3h,过滤,在55℃下浓缩成相对密度为1.2g/ml,干燥,制得干浸膏1;
b)称取处方量的皂刺、甘草、生地、乳香、穿山甲、石决明、天花粉、金银花、大黄和红花10味原料药,粉碎、碾磨、过筛制成细粉,所述筛网的数目为10-30目,在搅拌均匀后,加入5-10倍60%-85%乙醇的回流提取2次,每次1-2小时,滤过,合并回流液,在50~60℃下干燥,制得干浸膏2;
c)合并干浸膏1和干浸膏2,将其粉碎成粉,然后置于槽型混合机内混合30分钟,即得治疗皮肤病及乳腺增生的中药组合物。
进一步的,本发明提出治疗皮肤病及乳腺增生的中药组合物在制备治疗丹毒、浓疮、风疮、外痈、疮毒、疥藓以及乳腺增生的药物中的应用。
本发明提供的治疗皮肤病及乳腺增生的中药组合物,该中药组合物配方科学合理,各组分协同作用,疗效显著、安全方便且无毒副作用,没有任何西药或者激素药成分,抗菌、泻火、凉血、清热解毒、排脓、消肿,对丹毒、浓疮、风疮、外痈、疮毒、疥藓等皮肤病效果优异,复发率极低,活血祛瘀,并调理人体对乳腺增生和乳腺癌止痛也有很好的疗效。中药组合物制剂提高了药物的稳定性和生物利用率,本发明提供的治疗皮肤病及乳腺增生的中药组合物制备方法高效,提取有效成分效果好,适合工业生产。
具体实施方式
下面结合具体实施例来进一步描述本发明,本发明的优点和特点将会随着描述而更为清楚。但是应理解所述实施例仅是范例性的,不对本发明的范围构成任何限制。本领域技术人员应该理解的是,在不偏离本发明的精神和范围下可以对本发明技术方案的细节和形式进行修改或替换,但这些修改或替换均落入本发明的保护范围。
实施例1:
一种治疗皮肤病及乳腺增生的中药组合物,制备所述中药组合物的主要原料重量份组成为:防风15g、皂刺15g、甘草15g、生地15g、当归20g、连翘15g、乳香10g、沉香10g、穿山甲5g、石决明10g、天花粉20g、金银花20g、大黄15g,红花12g。
其中,治疗皮肤病及乳腺增生的中药组合物的制备方法,包括如下步骤:
a)称取处方量的防风、当归、连翘和沉香4味原料药加水煎煮2次,第一次15倍水量煎煮4h,第二次10倍水量煎煮2h,合并得煎液,温度50℃条件下浓缩成相对密度为1.2g/ml,冷却,加75%的乙醇进行醇沉3h,过滤,在55℃下浓缩成相对密度为1.2g/ml,干燥,制得干浸膏1;
b)称取处方量的皂刺、甘草、生地、乳香、穿山甲、石决明、天花粉、金银花、大黄和红花10味原料药,粉碎、碾磨、过筛制成细粉,所述筛网的数目为10-30目,在搅拌均匀后,加入5-10倍60%-85%乙醇的回流提取2次,每次1-2小时,滤过,合并回流液,在50~60℃下干燥,制得干浸膏2;
c)合并干浸膏1和干浸膏2,将其粉碎成粉,然后置于槽型混合机内混合30分钟,即得治疗皮肤病及乳腺增生的中药组合物。
实施例2:
一种治疗皮肤病及乳腺增生的中药组合物,制备所述中药组合物的主要原料重量份组成为:防风13g、皂刺12g、甘草12g、生地11g、当归18g、连翘10g、乳香6g、沉香9g、穿山甲4g、石决明9g、天花粉18g、金银花15g、大黄15g,红花11g。
其中,所述治疗皮肤病及乳腺增生的中药组合物的制备方法,和实施例1相同。
实施例3:
一种治疗皮肤病及乳腺增生的中药组合物,制备所述中药组合物的主要原料重量份组成为:
防风10g、皂刺12g、甘草10g、生地10g、当归15g、连翘8g、乳香5g、沉香8g、穿山甲3g、石决明8g、天花粉15g、金银花10g、大黄12g,红花10g。
其中,所述治疗皮肤病及乳腺增生的中药组合物的制备方法,和实施例1相同。
实施例4:
一种治疗皮肤病及乳腺增生的中药组合物,制备所述中药组合物的主要原料重量份组成为:
防风25g、皂刺20g、甘草25g、生地20g、当归30g、连翘20g、乳香20g、沉香25g、穿山甲15g、石决明20g、天花粉30g、金银花30g、大黄25g,红花25g。
其中,所述治疗皮肤病及乳腺增生的中药组合物的制备方法,和实施例1相同。
实施例5:
一种治疗皮肤病及乳腺增生的中药组合物,制备所述中药组合物的主要原料重量份组成为:
防风5g、皂刺10g、甘草6g、生地10g、当归10g、连翘5g、乳香4g、沉香5g、穿山甲3g、石决明5g、天花粉12g、金银花5g、大黄10g,红花10g。
其中,所述治疗皮肤病及乳腺增生的中药组合物的制备方法,和实施例1相同。
实施例6:
一种治疗皮肤病及乳腺增生的中药组合物,制备所述中药组合物的主要原料重量份组成为:
防风35g、皂刺30g、甘草36g、生地25g、当归45g、连翘30g、乳香30g、沉香35g、穿山甲20g、石决明25g、天花粉45g、金银花35g、大黄30g,红花35g。
其中,所述治疗皮肤病及乳腺增生的中药组合物的制备方法,和实施例1相同。
实施例7:
一种合剂,所述合剂由重量的成分组成:
常规方法制备。
实施例8:
一种合剂,所述合剂由重量的成分组成:
常规方法制备。
实施例9:
一种合剂,所述合剂由重量的成分组成:
常规方法制备。
对照例1:
一种合剂,所述合剂由重量的成分组成:
常规方法制备。
对照例2:
一种合剂,所述合剂由重量的成分组成:
常规方法制备。
试验例1稳定性试验
1.加速试验
取实施例7、实施例8、实施例9、对照例1和对照例2的合剂,分成3批,分别编号为样品1、样品2、样品3、样品4和样品5,在温度40℃±2℃下,相对湿度为75%±5%的条件下放置6个月,在试验期间1个月、2个月、3个月、6个月末分别取样一次,按中国药典中的规定,检测合剂的性状、色泽、气味和主要成分的含量(标示量%)、溶出度以及有关物质,结果发现,样品1、样品2和样品3各项指标均无明显变化,而样品4和样品5颜色变深,出现沉淀,并在6个月的时候均出现轻微异味。
2.长期试验
取实施例7、实施例8、实施例9、对照例1和对照例2的合剂,分成3批,分别编号为样品1、样品2、样品3、样品4和样品5,在温度25℃±2℃下,相对湿度为60%±10%的条件下放置24个月,在试验期间0个月、3个月、6个月、9个月、12个月、18个月、24个月末分别取样一次,按中国药典中的规定,检测合剂的性状、色泽、气味和主要成分的含量(标示量%)、溶出度以及有关物质,结果发现,样品1、样品2和样品3各项指标均无明显变化,而样品4和样品5颜色变深,出现沉淀,并在6个月的时候均出现轻微异味,在12个月时候出现轻微臭味。
结论本发明中药组合物制成的合剂由于辅料的合理选择,药品稳定性好、储存时间长,而黄原胶和羧甲基纤维素的加入更显著提高了合剂的稳定性。
试验例2毒性试验
(一)急性毒性试验
1.试验对象:健康SD大鼠
试验组50例,雄鼠,年龄5周龄;
对照组50例,雄鼠,年龄5周龄。
2.试验方法:
试验组:将本发明治疗皮肤病及乳腺增生的中药组合物用生理盐水配制成65%浓度的溶液,给大鼠按一次40ml/kg灌胃,一日内连续两次,然后停药,停药后继续观察7天。
对照组:用生理盐水给大鼠按一次40ml/kg灌胃,一日内连续两次,然后停药,停药后继续观察7天。
3.统计方法:分别在试验1天、2天、3天、4天、5天、6天、7天,记录两组大鼠的死亡率及大鼠行为有无明显异常;在观察期结束后,于第8天处死大鼠,进行剖检,记录两组大鼠的脏器异常改变情况。
4.试验结果:
试验结果见表1
表1急性毒性试验结果
表1的比较结果如下:
由试验组和对照组的比较可知,本发明治疗皮肤病及乳腺增生的中药组合物对大鼠没有急性毒性。
5.结论:本发明治疗皮肤病及乳腺增生的中药组合物,安全度高,无急性毒性。
(二)长期毒性试验
1.试验对象:健康SD大鼠
试验组50例,雄鼠,年龄5周龄;
对照组50例,雄鼠,年龄5周龄。
2.试验方法:
试验组:将本发明治疗皮肤病及乳腺增生的中药组合物溶解在水中灌胃,用药剂量以白鼠体重计,每日0.05g/kg,连续180天,停药后继续观察30天。
对照组:喂食与试验组一样且不含本发明中药组合物的食物,食物量也与试验组一样,并灌胃等量生理盐水,连续180天;随后的30天观察期期间,大鼠与试验组一样对待。
3.统计方法:分别在试验0天、30天、60天、90天、120天、150天、180天、及观察期结束时,记录两组大鼠的死亡率及大鼠行为有无明显异常;在观察期结束后,处死大鼠,进行剖检,记录两组大鼠的饮食、饮水、体重增长和脏器异常改变情况。
4.试验结果:试验结果见表2。
表2长期毒性试验结果
表2的比较结果如下:
由试验组和对照组的比较可知,本发明治疗皮肤病及乳腺增生的中药组合物对大鼠无长期毒性;
5.结论:本发明的治疗皮肤病及乳腺增生的中药组合物,安全度高,无长期毒性。
(三)结论
由急性毒性试验结果和长期毒性试验结果可知,本发明的治疗皮肤病及乳腺增生的中药组合物,安全度高,无毒性。
试验例3抑菌试验
使用下列化合物,采用本领域中经典的滤纸片法来进行抑菌试验。
供试菌种荚膜红细菌ATCC11166购自上海北诺生物科技有限公司。
培养液
营养琼脂和营养肉汤,购自北京中科晨宇实验设备有限公司。
试验方法
将荚膜红细菌ATCC11166接种于琼脂平板营养液平面上,接种时均匀密布。
取无菌圆形滤纸片,分别喷洒5ml的实施例1中中药组合物溶解成的溶液、5ml的实施例4中中药组合物溶解成的溶液,至完全润湿,贴在已接种细菌的琼脂平板营养液平面上。将琼脂平板置于37℃的培养箱内,温育4小时。测量抑菌环的直径。测定3次取平均值。
结论
实施例4中中药组合物溶解成的溶液的荚膜红细菌ATCC11166的抑菌环的平均直径为11.35mm,实施例1中中药组合物溶解成的溶液的荚膜红细菌ATCC11166的抑菌环的平均直径为13.96mm。
治疗乳腺增生的效果评价试验
本发明的能降脂减肥的中药组合物效果如下:
1.病例选择:
治疗组50例,年龄25~50岁,平均30岁;
对照组50例,年龄25~50岁,平均30岁。
诊断标准:病程2个月~3年,均为单侧乳房发病。所治患者均以乳房胀痛为主症来就诊,患者自觉一侧乳房胀痛,疼痛部位可摸到颗粒状、条索状肿块,表面光滑,与皮肤不粘连。经前期疼痛加重,经后减弱或消失,或伴有心烦易怒,嗳气,善太息等症状。诊断标准参照《外科学》乳腺增生病的诊断标准:1)单侧或双侧乳腺出现疼痛,多数具有周期性,发作与月经周期有关,月经前几天疼痛加重,月经来潮后减轻或消失;2)体检发现一侧或双侧乳腺腺体局限性或弥漫性增厚,肿块呈颗粒状,大小不一,质韧而不硬,增厚区与周围正常乳腺组织分界不清;3)本病病程较长,发展缓慢,好发于中年妇女;4)少数患者可合并有乳头溢液,为浆液性或浆血性,如有上述两条以上者,可确认为本病。必要时利用钼靶X线、B超、热象图等辅助检测手段,或行肿块针吸细胞学检查及局部活组织病理检查,以排除乳腺癌、乳腺纤维瘤等其它良、恶性疾病。
2.给药方式:
治疗组:使用本发明的治疗皮肤病及乳腺增生的中药组合物的合剂,每日3次,三周为一个疗程,连续使用三个疗程。
对照组:广州中一药业有限公司的乳核散结片,每日3次,饭后温水口服,三周为一个疗程,连续使用三个疗程。
3.疗效标准:
临床治愈:疼痛及肿块均消失,乳头无溢液且维持6个月者;
显效:疼痛消失,增厚的肿块软化并散开,肿块缩小大于50%者;
有效:疼痛明显缓解,肿块变软,肿块缩小小于50%者;
无效:疼痛无缓解,肿块大小、质地无改变。5.试验结果:
空白组、治疗组和对照组的疗效比较结果见表3;
表3治疗组和对照组的疗效比较
治疗组和对照组比较具有显著差异(P<0.01)。
重者服药两个疗程明显好转,三个疗程即痊愈。治疗75例,临床治愈46例(61.3%),显效8例(10.7%),有效17例(22.7%),无效4例(5.3%),总有效率94.7%。
6.效果判定:本发明的能降脂减肥的中药组合物及由其制得的制剂,治疗前以乳房肿块、乳房疼痛为观察指标,结果显示本发明的治疗皮肤病及乳腺增生的中药组合物的合剂在缓解乳房疼痛、缩小乳房肿块方面均有显著效果,轻者服药两疗程即明显好转,三个疗程即愈。有效率96%、痊愈率82%,治愈效果显著优于对照组。
治疗皮肤病的效果评价试验
临床用药情况:
本发明中药组合物已用于临床试用多年,根据近3年用药情况统计,治疗各类病人1200例,病症类型包括丹毒、浓疮、风疮、外痈、疮毒、疥藓等。
治疗效果:
疗效判断标准,按疗程用药,以病症明显好转或消失为有效,六个月后不复发为治愈。经用药后观察,有效率为100%,治愈率达95%以上。按病症类型临床治疗情况如下表4:
表4不同病症类型的治疗效果
典型病例1:
韩某,女,33岁,主症双侧乳腺疼痛1年,双侧乳腺外上象限可触及片状包块,质硬,经前尤甚,月经不调,双侧乳腺小叶增生,服用本发明的治疗皮肤病及乳腺增生的中药组合物的合剂治疗3个疗程,乳房胀痛消失,继服1个疗程以巩固疗效。
典型病例2:
于某,女,25岁,面部长有数个疔疮,初起为毛囊口脓疮隆起呈圆锥形的炎性硬结,状如粟粒,有明显的疼痛感;涂覆普通外科药膏治疗数周,不见效果,后使用本发明的治疗皮肤病及乳腺增生的中药组合物的合剂,每日服用三次,两周一疗程,服用一个疗程,患处硬结明显变软,并逐渐变小,后继续涂覆一疗程,疔疮消失,痊愈。
Claims (9)
1.一种治疗皮肤病及乳腺增生的中药组合物,其特征在于,制备所述中药组合物的主要原料重量份组成为:防风5-35份、皂刺10-30份、甘草6-36份、生地10-25份、当归10-45份、连翘5-30份、乳香4-30份、沉香5-35份、穿山甲3-20份、石决明5-25份、天花粉12-45份、金银花5-35份、大黄10-30份,红花10-35份。
2.根据权利要求1所述的治疗皮肤病及乳腺增生的中药组合物,其特征在于,制备所述中药组合物的主要原料重量份组成为:防风10-25份、皂刺12-20份、甘草10-25份、生地10-20份、当归15-30份、连翘8-20份、乳香5-20份、沉香8-25份、穿山甲3-15份、石决明8-20份、天花粉15-30份、金银花10-30份、大黄12-25份,红花10-25份。
3.根据权利要求2所述的治疗皮肤病及乳腺增生的中药组合物,其特征在于,制备所述中药组合物的主要原料重量份组成为:防风15份、皂刺15份、甘草15份、生地15份、当归20份、连翘15份、乳香10份、沉香10份、穿山甲5份、石决明10份、天花粉20份、金银花20份、大黄15份,红花12份。
4.根据权利要求1-3中任一项所述的治疗皮肤病及乳腺增生的中药组合物和辅料制备的制剂,其特征在于,所述制剂包括合剂、片剂、胶囊剂、颗粒剂、注射剂或丸剂,所述中药组合物和辅料的重量比为1:3.5-6。
5.根据权利要求4中所述的制剂,其特征在于,所述制剂为合剂,所述辅料由以下重量份数的成分组成:195-220份的水、40-65份的盐酸半胱氨酸、60-85份的桂皮油、25-35份的对羟基苯甲酸丙酯钠盐、42-60份的甘草酸二钠。
6.根据权利要求5中所述的制剂,其特征在于,所述辅料还包括重量份数为35-47份的黄原胶、25-35份的羧甲基纤维素。
7.根据权利要求6中所述的制剂,其特征在于,制备所述制剂所用的中药组合物和辅料的重量份为:
8.一种权利要求1-3中任一项所述的治疗皮肤病及乳腺增生的中药组合物的制备方法,其特征在于,所述方法包括如下步骤:
a)称取处方量的防风、当归、连翘和沉香4味原料药加水煎煮2次,第一次15倍水量煎煮4h,第二次10倍水量煎煮2h,合并得煎液,温度50℃条件下浓缩成相对密度为1.2g/ml,冷却,加75%的乙醇进行醇沉3h,过滤,在55℃下浓缩成相对密度为1.2g/ml,干燥,制得干浸膏1;
b)称取处方量的皂刺、甘草、生地、乳香、穿山甲、石决明、天花粉、金银花、大黄和红花10味原料药,粉碎、碾磨、过筛制成细粉,所述筛网的数目为10-30目,在搅拌均匀后,加入5-10倍60%-85%乙醇的回流提取2次,每次1-2小时,滤过,合并回流液,在50~60℃下干燥,制得干浸膏2;
c)合并干浸膏1和干浸膏2,将其粉碎成粉,然后置于槽型混合机内混合30分钟,即得治疗皮肤病及乳腺增生的中药组合物。
9.一种权利要求1-3任一项所述的中药组合物,在制备治疗丹毒、浓疮、风疮、外痈、疮毒、疥藓以及乳腺增生的药物中的应用。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610278891.6A CN105748728A (zh) | 2016-04-29 | 2016-04-29 | 一种治疗皮肤病及乳腺增生的中药组合物及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610278891.6A CN105748728A (zh) | 2016-04-29 | 2016-04-29 | 一种治疗皮肤病及乳腺增生的中药组合物及其制备方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN105748728A true CN105748728A (zh) | 2016-07-13 |
Family
ID=56324578
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610278891.6A Pending CN105748728A (zh) | 2016-04-29 | 2016-04-29 | 一种治疗皮肤病及乳腺增生的中药组合物及其制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN105748728A (zh) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1709497A (zh) * | 2005-06-29 | 2005-12-21 | 贵州苗莹药业科技开发有限公司 | 一种苗药组合物及其应用 |
CN1739706A (zh) * | 2005-09-09 | 2006-03-01 | 郝天发 | 消炎解毒的药物点舌丸 |
-
2016
- 2016-04-29 CN CN201610278891.6A patent/CN105748728A/zh active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1709497A (zh) * | 2005-06-29 | 2005-12-21 | 贵州苗莹药业科技开发有限公司 | 一种苗药组合物及其应用 |
CN1739706A (zh) * | 2005-09-09 | 2006-03-01 | 郝天发 | 消炎解毒的药物点舌丸 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN103830635B (zh) | 一种治疗月经不调、闭经的中药制剂 | |
CN105749179A (zh) | 治疗代谢综合征的中药组合物 | |
CN101129994A (zh) | 一种治疗黄疸的中药组合物 | |
CN115770279B (zh) | 用于治疗慢性下肢静脉疾病的中药组合物及其汤剂和制剂 | |
CN104826036A (zh) | 一种治疗乳腺增生的复合中药组合物及制备方法 | |
CN113827687A (zh) | 一种用于治疗甲状腺结节的中药组方制剂及其制备方法 | |
CN103920034A (zh) | 减轻肿瘤病人化疗副反应的中药组合物及制法 | |
CN101023992B (zh) | 治疗乳腺增生病的药物 | |
CN101897785A (zh) | 一种具有祛痤疮功能的药物组合物及其制备方法 | |
CN101618201B (zh) | 一种治疗外阴粘膜白斑的药物 | |
CN106039196B (zh) | 一种治疗高脂血症的药物组合物 | |
CN104491718B (zh) | 一种治疗肝郁痰凝型乳腺增生的药物及制备方法 | |
CN105998495A (zh) | 一种治疗烫伤的中药组合物及其制备方法 | |
CN103356870B (zh) | 一种治疗产后缺乳的中药制剂及制备方法 | |
CN103212030B (zh) | 一种治疗肝郁型乳腺增生的中药及制备方法 | |
CN105770691A (zh) | 一种用于治疗宫颈癌的药物制剂及其用途 | |
CN105748728A (zh) | 一种治疗皮肤病及乳腺增生的中药组合物及其制备方法 | |
CN105106840A (zh) | 祛痛消炎止呕汤 | |
CN114712466B (zh) | 一种具有减肥养颜功效的药物及其制备方法 | |
CN114632127B (zh) | 一种治疗小儿黄疸的中药组合物、制剂及其制备方法和应用 | |
CN115252679B (zh) | 一种治疗缺血性心肌病的中药组合物及其应用 | |
CN102988883B (zh) | 一种治疗肝炎的药物及其制备方法 | |
CN100415289C (zh) | 一种治疗白癜风的中药制剂 | |
CN105456951A (zh) | 一种治疗乳房纤维腺瘤的中药制剂及其制备方法 | |
CN100353987C (zh) | 一种治疗痤疮的中药制剂 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160713 |