CN105722974B - 全能干细胞的诱导方法、及用该方法制备的全能干细胞 - Google Patents

全能干细胞的诱导方法、及用该方法制备的全能干细胞 Download PDF

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CN105722974B
CN105722974B CN201480019489.5A CN201480019489A CN105722974B CN 105722974 B CN105722974 B CN 105722974B CN 201480019489 A CN201480019489 A CN 201480019489A CN 105722974 B CN105722974 B CN 105722974B
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stem cells
cells
extract
shikimic acid
present
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CN105722974A (zh
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金雅凛
金秀娜
朴元锡
权裕旭
朴永培
金孝洙
白宰承
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Amorepacific Corp
SNU R&DB Foundation
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Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102016062B1 (ko) * 2016-04-26 2019-08-30 주식회사 바이오에프디엔씨 미백개선과 주름개선 효과를 갖는 배 캘러스와 유자 캘러스 소재
KR101920650B1 (ko) * 2018-01-24 2019-01-30 주식회사 바람인터내셔날 다알리아 조성물, 다알리아 조성물 분말, 화장료 조성물 및 그 제조방법
WO2020139057A2 (ko) * 2018-12-28 2020-07-02 연세대학교 산학협력단 팔각회향 추출물 또는 시킴산을 함유하는 근육 질환 예방 및 치료용 또는 근 기능 개선용 조성물
WO2020240056A1 (es) * 2019-10-16 2020-12-03 Mesoestetic Pharma Group, S.L Composiciones cosméticas y utilización de las mismas
KR102299417B1 (ko) * 2019-12-12 2021-09-07 (주)아모레퍼시픽 노화 피부세포 주변 환경변화 유도 촉진용 조성물
KR102408566B1 (ko) * 2020-04-09 2022-06-16 대한민국 터미날리아 비아라타 추출물을 이용한 피부 주름 개선용 조성물
CN113005079B (zh) * 2021-05-08 2022-12-06 威海见生生物技术有限公司 一种人骨髓间充质干细胞体外扩增用添加剂及扩增方法
KR102783281B1 (ko) * 2021-09-01 2025-03-21 주식회사 뉴셀팜 푸른여로 추출물을 이용한 피부 주름 개선 및 피부 미백용 조성물
JP7763260B2 (ja) * 2021-09-14 2025-10-31 株式会社アルビオン ブナ科植物由来カルス、カルス抽出物、それを用いた方法および化粧品組成物
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CN114591894B (zh) * 2022-02-28 2024-01-09 中国人民解放军总医院 一种皮肤多能前体干细胞的制备方法及其应用
CN115369081B (zh) * 2022-08-24 2024-01-02 吉林大学 一种干细胞生长促进剂及其制备的细胞培养基和应用
WO2024128333A1 (ko) * 2022-12-12 2024-06-20 주식회사 뉴셀팜 푸른여로 추출물을 이용한 피부 주름 개선 및 피부 미백용 조성물

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20090104223A (ko) * 2008-03-31 2009-10-06 (주)아모레퍼시픽 항노화용 화장료 조성물
KR20110032989A (ko) * 2009-09-22 2011-03-30 서울대학교병원 성체세포로부터 만능줄기세포를 유도하는 방법 및 그 방법에 의해 제조된 만능줄기세포
KR20120058829A (ko) * 2010-11-30 2012-06-08 (주)아모레퍼시픽 세콰이어 캘러스 추출물을 함유하는 지방유래 줄기세포의 줄기세포성 증진용 및 피부세포 증식용 조성물

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR19980034293A (ko) 1996-11-06 1998-08-05 성재갑 갈로일시키믹산을 함유하는 피부 미백용 조성물
KR19980034293U (ko) * 1996-12-10 1998-09-15 박병재 자동차의 배기 가스 후압력 감소 장치
DE19818541C2 (de) * 1998-04-24 2003-04-10 Forschungszentrum Juelich Gmbh Mikrobielle Herstellung von Substanzen aus dem aromatischen Stoffwechsel / III
US6613552B1 (en) * 1999-01-29 2003-09-02 Board Of Trustees Operating Michigan State University Biocatalytic synthesis of shikimic acid
TWI282275B (en) * 2000-08-17 2007-06-11 Control Ox Oy Plant-derived and synthetic phenolic compounds and plant extracts, effective in the treatment and prevention of chlamydial infections
US20020142397A1 (en) * 2000-12-22 2002-10-03 Philippe Collas Methods for altering cell fate
AU2002315337A1 (en) * 2001-06-18 2003-01-02 Psychiatric Genomics, Inc. Method for neural stem cell differentiation using valproate
EP1799228B1 (en) * 2004-09-14 2010-04-14 Ajinomoto Omnichem S.A. Topical compositions containing phosphorylated polyphenols
ITMI20050498A1 (it) 2005-03-24 2006-09-25 Giuliani Spa Composizione a base di estratti vegetali di ajuga reptans per prevenire la caduta dei capelli stimolare la crescita dei capelli regolare la produzione di sebo
JP5559463B2 (ja) * 2008-03-12 2014-07-23 株式会社コーセー シキミ酸を有効成分とする美白剤
KR101121883B1 (ko) * 2010-11-24 2012-03-20 주식회사 바이오에프디엔씨 세인트존스워트 캘러스 추출물을 함유하는 피부 외용제 조성물
WO2012158216A1 (en) * 2011-05-16 2012-11-22 Beech Tree Labs, Inc. Methods of treating a disorder associated with sequestered bacteria
KR101279092B1 (ko) * 2011-09-28 2013-06-26 건국대학교 산학협력단 형절전환체를 이용한 클로로겐산의 합성

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20090104223A (ko) * 2008-03-31 2009-10-06 (주)아모레퍼시픽 항노화용 화장료 조성물
KR20110032989A (ko) * 2009-09-22 2011-03-30 서울대학교병원 성체세포로부터 만능줄기세포를 유도하는 방법 및 그 방법에 의해 제조된 만능줄기세포
KR20120058829A (ko) * 2010-11-30 2012-06-08 (주)아모레퍼시픽 세콰이어 캘러스 추출물을 함유하는 지방유래 줄기세포의 줄기세포성 증진용 및 피부세포 증식용 조성물

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Emerging Methods for Preparing iPS Cells;Susumu Miyazaki et al.;《Jpn J Clin Oncol》;20121231;773–779 *
ES Cell Extract-Induced Expression of Pluripotent Factors in Somatic Cells;YAN-NING XU et al.;《THE ANATOMICAL RECORD》;20091231;1229–1234 *
Shikimic acid: review of its analytical, isolation,and purification techniques from plant and microbial sources;D. V. Bochkov et al.;《J Chem Biol》;20110724;5–17 *

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