CN105709163A - Guan Maining tablet and preparation method thereof - Google Patents
Guan Maining tablet and preparation method thereof Download PDFInfo
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- CN105709163A CN105709163A CN201410703480.8A CN201410703480A CN105709163A CN 105709163 A CN105709163 A CN 105709163A CN 201410703480 A CN201410703480 A CN 201410703480A CN 105709163 A CN105709163 A CN 105709163A
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- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims abstract description 30
- 229910002092 carbon dioxide Inorganic materials 0.000 claims abstract description 15
- 239000001569 carbon dioxide Substances 0.000 claims abstract description 15
- 238000001035 drying Methods 0.000 claims abstract description 10
- 238000000605 extraction Methods 0.000 claims abstract description 8
- 238000000194 supercritical-fluid extraction Methods 0.000 claims abstract description 8
- 239000006071 cream Substances 0.000 claims description 21
- 239000000843 powder Substances 0.000 claims description 21
- 210000000582 semen Anatomy 0.000 claims description 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 14
- 238000002156 mixing Methods 0.000 claims description 14
- 239000009286 sanguis draxonis Substances 0.000 claims description 9
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 8
- 229920001353 Dextrin Polymers 0.000 claims description 8
- 239000004375 Dextrin Substances 0.000 claims description 8
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 8
- 229930195725 Mannitol Natural products 0.000 claims description 8
- 229920002472 Starch Polymers 0.000 claims description 8
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 8
- 239000009670 cang er zi wan Substances 0.000 claims description 8
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 8
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims description 8
- 238000004132 cross linking Methods 0.000 claims description 8
- 235000019425 dextrin Nutrition 0.000 claims description 8
- 239000000594 mannitol Substances 0.000 claims description 8
- 235000010355 mannitol Nutrition 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 8
- 229910052708 sodium Inorganic materials 0.000 claims description 8
- 239000011734 sodium Substances 0.000 claims description 8
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 8
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 8
- 239000008107 starch Substances 0.000 claims description 8
- 235000019698 starch Nutrition 0.000 claims description 8
- 239000000284 extract Substances 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 7
- 238000000227 grinding Methods 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 7
- 239000002245 particle Substances 0.000 claims description 7
- 238000005550 wet granulation Methods 0.000 claims description 7
- 206010002383 Angina Pectoris Diseases 0.000 claims description 6
- 206010052895 Coronary artery insufficiency Diseases 0.000 claims description 5
- 208000029078 coronary artery disease Diseases 0.000 claims description 5
- 239000003814 drug Substances 0.000 claims description 5
- 230000000694 effects Effects 0.000 abstract description 7
- 244000144730 Amygdalus persica Species 0.000 abstract description 2
- 235000014375 Curcuma Nutrition 0.000 abstract description 2
- 244000163122 Curcuma domestica Species 0.000 abstract description 2
- 241000737253 Lygodium japonicum Species 0.000 abstract description 2
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 abstract description 2
- 239000000463 material Substances 0.000 abstract 2
- 241000213006 Angelica dahurica Species 0.000 abstract 1
- 235000003805 Musa ABB Group Nutrition 0.000 abstract 1
- 240000008790 Musa x paradisiaca Species 0.000 abstract 1
- 235000015266 Plantago major Nutrition 0.000 abstract 1
- 244000292697 Polygonum aviculare Species 0.000 abstract 1
- 235000006386 Polygonum aviculare Nutrition 0.000 abstract 1
- 235000006040 Prunus persica var persica Nutrition 0.000 abstract 1
- 240000007164 Salvia officinalis Species 0.000 abstract 1
- 241000913745 Spatholobus Species 0.000 abstract 1
- 244000067505 Xanthium strumarium Species 0.000 abstract 1
- 239000009136 dragon's blood Substances 0.000 abstract 1
- 235000005412 red sage Nutrition 0.000 abstract 1
- 239000009910 sargent gloryvine Substances 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 description 5
- 208000011580 syndromic disease Diseases 0.000 description 5
- 241000345998 Calamus manan Species 0.000 description 3
- 235000013399 edible fruits Nutrition 0.000 description 3
- 230000010354 integration Effects 0.000 description 3
- 235000012950 rattan cane Nutrition 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- 241000961970 Plantago depressa Species 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 230000004345 fruit ripening Effects 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 230000005070 ripening Effects 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 235000011446 Amygdalus persica Nutrition 0.000 description 1
- 241000382455 Angelica sinensis Species 0.000 description 1
- 235000008495 Chrysanthemum leucanthemum Nutrition 0.000 description 1
- 244000192528 Chrysanthemum parthenium Species 0.000 description 1
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 description 1
- 240000009138 Curcuma zedoaria Species 0.000 description 1
- 235000003405 Curcuma zedoaria Nutrition 0.000 description 1
- 241000005043 Lygodiaceae Species 0.000 description 1
- 244000021150 Orbignya martiana Species 0.000 description 1
- 235000014643 Orbignya martiana Nutrition 0.000 description 1
- 235000019082 Osmanthus Nutrition 0.000 description 1
- 241000333181 Osmanthus Species 0.000 description 1
- 206010033557 Palpitations Diseases 0.000 description 1
- 241000013557 Plantaginaceae Species 0.000 description 1
- 240000002381 Prunus davidiana Species 0.000 description 1
- 241000800405 Spatholobus suberectus Species 0.000 description 1
- 235000013527 bean curd Nutrition 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 239000001812 curcuma zedoaria berg. rosc. Substances 0.000 description 1
- 230000006837 decompression Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 235000008384 feverfew Nutrition 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 238000009738 saturating Methods 0.000 description 1
- 235000019509 white turmeric Nutrition 0.000 description 1
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- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a Guan Maining tablets and a preparation method thereof. The preparation method is characterized by comprising the following steps: taking 100 g of lygodium japonicum, 100 g of cocklebur sargentgloryvine stem, 112.5 g of red sage root, 112.5 g of spatholobus stem, 25.5 g of dragons blood, 45 g of plantain seed, 45 g of Chinese angelica, 45 g of curcuma tuber, 75 g of prepared tuber of multiflower knotweed, and 30 g of peach seed (fried); employing a carbon dioxide supercritical extraction method for extraction, drying the materials under reduced pressure, using a high-energy nano impingement mill for crushing a nano dry paste, and adding functional auxiliary materials to obtain the Guan Maining tablets. The Guan Maining tablets have the advantages that the disintegration time is obviously shortened, compared with the commercially available Guan Maining tablets, curative effect of the Guan Maining tablets provided by the invention is better, and active effect can be achieved.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of peaceful sheet of arteria coronaria and preparation method thereof.
Background technology
The peaceful sheet blood circulation promoting and blood stasis dispelling of arteria coronaria, promoting the circulation of QI to relieve pain.This product be mainly used in stabbing pain over the chest, fixing do not move, enter Night Watch very, palpitation and uneasiness, purplish tongue, deep and stringy pulse be primary symptom coronary heart diseases and angina pectoris, coronary insufficiency.The peaceful sheet of commercially available arteria coronaria is due to prescription and technological reason, and curative effect is not satisfactory, and preparation adopts traditional handicraft to prepare, and there is the deficiencies such as prolonged disintegration, curative effect are low.
Summary of the invention
The present invention is for overcoming above-mentioned deficiency, it is provided that peaceful sheet of arteria coronaria that a kind of disintegration rate is fast, curative effect is high and preparation method thereof.
Invention embodiment is as follows:
Take Spora Lygodii 100g, Fructus Xanthii 100g, Radix Salviae Miltiorrhizae 112.5g, Caulis Spatholobi 112.5g, Sanguis Draxonis 25.5g, Semen Plantaginis 45g, Radix Angelicae Sinensis 45g, Radix Curcumae 45g, Radix Polygoni Multiflori Preparata 75g, Semen Persicae (stir-fry) 30g, it is ground into 60 order coarse powder, adopts carbon dioxide supercritical extraction method to extract, extracting pressure 30～40Mpa, extraction temperature 30～40 DEG C, separator pressure 10～20Mpa, separator temperature 50～60 DEG C, disengaging time 2～4 hours, carbon dioxide flow is 40～50L per hour, obtains extracting solution；Take 60 DEG C～80 DEG C drying under reduced pressure of extracting solution, get dry extract；Take dry cream and add mannitol 150～200g, adopt high energy nanometer impact grinding to be ground into the mixing dried cream powder of particle diameter 200～300nm；Take mixing dried cream powder, dextrin 45～55g, crospolyvinylpyrrolidone 45～55g, cross-linking sodium carboxymethyl cellulose 35～45g, mix homogeneously, with 50～70% ethanol wet granulations, 60 DEG C～80 DEG C dry, additional carboxymethyl starch sodium 7～9g, granulate, is pressed into 1500, prepares the peaceful sheet of arteria coronaria.
The raw material standards that the embodiment above is previously mentioned is as follows:
Spora Lygodii: China's coastal port one ministerial standard.This product is Lygodiaceae plant Spora Lygodii Lygodiumjaponicum(Thunb.) the drying and ripening spore of Sw..Autumn, spore tapped rattan leaf when not falling off, and dried, and crumpled or lay spore, removed rattan leaf.
Fructus Xanthii: China's coastal port one ministerial standard.This product is the drying and ripening of the feverfew Herba Xanthii XanthiumsibiricumPatr. fruit with involucre.Gather during fruit maturation in autumn, dry, remove the impurity such as stalk, leaf.
Radix Salviae Miltiorrhizae: China's coastal port one ministerial standard.This product is the dry root and rhizome of labiate Radix Salviae Miltiorrhizae SalviamiltiorrhizaBge..Spring, season in autumn two excavate, and remove silt, dry.
Caulis Spatholobi: China's coastal port one ministerial standard.This product is the dry rattan of leguminous plant spatholobus suberectus SpatholobussuberectusDunn.Autumn, season in winter two gather, and remove branch and leaf, section, dry.
Sanguis Draxonis: China's coastal port one ministerial standard.This product is that resin that babassu Sanguis Draxonis DaemonoropsdracoBl. fruit oozes out is processed to be made.
Semen Plantaginis: China's coastal port one ministerial standard.This product is the dry mature seed of Plantaginaceae plant Herba Plantaginis PlantagoasiaticaL. or Plantago depressa Willd PlantagodepressaWilld..Gather when summer, autumn two season seed maturity fruit ear, dry, rub seed, remove impurity.
Radix Angelicae Sinensis: China's coastal port one ministerial standard.This product is umbelliferae angelica Angelicasinensis(Oliv.) dry root of Diels.Autumn end excavates, and removes fibrous root and silt, after moisture slightly evaporates, is bundled into wisp, and upper canopy, with pyrotechnics slowly smoke-dried beancurd.
Radix Curcumae: China's coastal port one ministerial standard.This product is the dried root of zingiberaceous plant RADIX CURCUMAE CurcumawenyujinY.H.ChenetC.Ling, Rhizoma Curcumae Longae CurcumalongaL., Guangxi zedoary CurcumakwaugsienisS.G.LeeetC.F.Liang or Rhizoma Curcumae Curcumapha-eocaulisVal..The above two practise title " RADIX CURCUMAE " and " Radix Curcuma " respectively, and all the other are practised by character difference and claim " osmanthus Radix Curcumae " or " green filament Radix Curcumae ".Winter, stem and leaf was excavated after withering, and removes silt and radicula, steams or boil to the saturating heart, dry.
Radix Polygoni Multiflori Preparata: China's coastal port one ministerial standard.This product is the Preparation process product of Radix Polygoni Multiflori.
Semen Persicae: China's coastal port one ministerial standard.This product is rosaceous plant Fructus Persicae Prunuspersica(L.) Batsch or Prunus davidiana Prunusdavidiana(Cars.) dry mature seed of Franch..Gather after fruit maturation, remove sarcocarp and nucleocapsid, take out seed, dry.
Mannitol: Chinese Pharmacopoeia version two ministerial standard in 2010.
Dextrin: Chinese Pharmacopoeia version two ministerial standard in 2010.
Crospolyvinylpyrrolidone: Chinese Pharmacopoeia version two ministerial standard in 2010.
Cross-linking sodium carboxymethyl cellulose: Chinese Pharmacopoeia version two ministerial standard in 2010.
Carboxymethyl starch sodium: Chinese Pharmacopoeia version two ministerial standard in 2010.
Raw material used in the peaceful sheet of above arteria coronaria all can be commercially available from pharmaceuticals, all can be used to implement the present invention program as long as meeting national standard.
In foregoing invention scheme, term used is pharmacy proprietary term, all defers to Chinese Pharmacopoeia regulation and pharmaceutical practice of being correlated with such as " decompression " etc..
Unit g in the present invention can also be other weight portion, does not affect the enforcement of the present invention program.
Equipment Market described in the present invention program all has sale, however it is not limited to typical production producer, as long as technical specification can reach requirement, all can be used to realize the present invention.
Four detailed description of the invention
Specific embodiments of the invention 1
Take Spora Lygodii 100g, Fructus Xanthii 100g, Radix Salviae Miltiorrhizae 112.5g, Caulis Spatholobi 112.5g, Sanguis Draxonis 25.5g, Semen Plantaginis 45g, Radix Angelicae Sinensis 45g, Radix Curcumae 45g, Radix Polygoni Multiflori Preparata 75g, Semen Persicae (stir-fry) 30g, it is ground into 60 order coarse powder, adopts carbon dioxide supercritical extraction method to extract, extracting pressure 30Mpa, extraction temperature 30 DEG C, separator pressure 10Mpa, separator temperature 50 DEG C, disengaging time 2 hours, carbon dioxide flow is 40L per hour, obtains extracting solution；Take 60 DEG C of drying under reduced pressure of extracting solution, get dry extract；Take dry cream and add mannitol 150g, adopt high energy nanometer impact grinding to be ground into the mixing dried cream powder of particle diameter 200～300nm；Taking mixing dried cream powder, dextrin 45g, crospolyvinylpyrrolidone 45g, cross-linking sodium carboxymethyl cellulose 35g, mix homogeneously, with 50% ethanol wet granulation, 60 DEG C dry, additional carboxymethyl starch sodium 7g, and granulate is pressed into 1500, prepares the peaceful sheet of arteria coronaria.
Specific embodiments of the invention 2
Take Spora Lygodii 100g, Fructus Xanthii 100g, Radix Salviae Miltiorrhizae 112.5g, Caulis Spatholobi 112.5g, Sanguis Draxonis 25.5g, Semen Plantaginis 45g, Radix Angelicae Sinensis 45g, Radix Curcumae 45g, Radix Polygoni Multiflori Preparata 75g, Semen Persicae (stir-fry) 30g, it is ground into 60 order coarse powder, adopts carbon dioxide supercritical extraction method to extract, extracting pressure 40Mpa, extraction temperature 40 DEG C, separator pressure 20Mpa, separator temperature 60 DEG C, disengaging time 4 hours, carbon dioxide flow is 50L per hour, obtains extracting solution；Take 80 DEG C of drying under reduced pressure of extracting solution, get dry extract；Take dry cream and add mannitol 200g, adopt high energy nanometer impact grinding to be ground into the mixing dried cream powder of particle diameter 200～300nm；Taking mixing dried cream powder, dextrin 55g, crospolyvinylpyrrolidone 55g, cross-linking sodium carboxymethyl cellulose 45g, mix homogeneously, with 70% ethanol wet granulation, 80 DEG C dry, additional carboxymethyl starch sodium 9g, and granulate is pressed into 1500, prepares the peaceful sheet of arteria coronaria.
Specific embodiments of the invention 3
Take Spora Lygodii 100g, Fructus Xanthii 100g, Radix Salviae Miltiorrhizae 112.5g, Caulis Spatholobi 112.5g, Sanguis Draxonis 25.5g, Semen Plantaginis 45g, Radix Angelicae Sinensis 45g, Radix Curcumae 45g, Radix Polygoni Multiflori Preparata 75g, Semen Persicae (stir-fry) 30g, it is ground into 60 order coarse powder, adopts carbon dioxide supercritical extraction method to extract, extracting pressure 35Mpa, extraction temperature 35 DEG C, separator pressure 15Mpa, separator temperature 55 DEG C, disengaging time 3 hours, carbon dioxide flow is 45L per hour, obtains extracting solution；Take 70 DEG C of drying under reduced pressure of extracting solution, get dry extract；Take dry cream and add mannitol 175g, adopt high energy nanometer impact grinding to be ground into the mixing dried cream powder of particle diameter 200～300nm；Taking mixing dried cream powder, dextrin 50g, crospolyvinylpyrrolidone 50g, cross-linking sodium carboxymethyl cellulose 40g, mix homogeneously, with 60% ethanol wet granulation, 70 DEG C dry, additional carboxymethyl starch sodium 8g, and granulate is pressed into 1500, prepares the peaceful sheet of arteria coronaria.
Above example illustrates, adopts the extreme condition of embodiment of the present invention and optimal conditions all can make the peaceful sheet of arteria coronaria.The peaceful sheet of arteria coronaria prepared with embodiment 3 below investigates the actual effect of the present invention:
(1) the peaceful sheet of embodiment 3 arteria coronaria and peaceful sheet contrast disintegration of commercially available arteria coronaria
1 disintegration time mensuration method
Measure by Chinese Pharmacopoeia version annex Ⅻ A in 2010.
Contrast 2 disintegrations
The table 1 embodiment 3 peaceful sheet of arteria coronaria and commercially available arteria coronaria peaceful sheet contrast table disintegration
The above results shows, the peaceful sheet of arteria coronaria prepared by the present invention has the remarkable advantages such as disintegration rate is fast, bioavailability is high relative to the peaceful sheet of commercially available arteria coronaria.
(2) the peaceful sheet of embodiment 3 arteria coronaria and commercially available arteria coronaria peaceful sheet treatment coronary heart diseases and angina pectoris, coronary insufficiency clinical observation on the therapeutic effect
1 case scenario
Statistics outpatient service and inpatient, observe coronary heart diseases and angina pectoris, coronary insufficiency case 110 example, 54 years old mean age altogether.Patient is divided into two groups, and test group takes the embodiment 3 peaceful sheet of arteria coronaria, and matched group takes the peaceful sheet of commercially available arteria coronaria.
2 efficacy assessment standards
According to new Chinese medicine treatment angina pectoris guideline of clinical investigations tcm syndrome curative effect determinate standard:
Effective: tcm clinical practice symptom, sign are obviously improved, syndrome integral reduces >=70%.
Effective: tcm clinical practice symptom, sign all take a favorable turn, syndrome integral reduces >=30%.
Invalid: tcm clinical practice symptom, sign are all not improved or increase the weight of, syndrome integral reduces < 30%.
Increasing the weight of: tcm clinical practice symptom, sign all have and increase the weight of, syndrome integral reduces < 0.
Computing formula: [before (before treatment integration after integration-treatment) ÷ treatment integration] × 100%.
3 clinical observation result
The table 2 embodiment 3 peaceful sheet of arteria coronaria and the peaceful sheet clinical efficacy contrast table of commercially available arteria coronaria
Above-mentioned clinical observation on the therapeutic effect is it is shown that the peaceful sheet of arteria coronaria prepared of the present invention is when treating coronary heart diseases and angina pectoris, coronary insufficiency, evident in efficacy higher than the peaceful sheet of commercially available arteria coronaria, p < 0.05.
Claims (3)
1. a treatment coronary heart disease, angina pectoris, the Chinese medicine of coronary insufficiency, it is characterized in that taking Spora Lygodii 100g, Fructus Xanthii 100g, Radix Salviae Miltiorrhizae 112.5g, Caulis Spatholobi 112.5g, Sanguis Draxonis 25.5g, Semen Plantaginis 45g, Radix Angelicae Sinensis 45g, Radix Curcumae 45g, Radix Polygoni Multiflori Preparata 75g, Semen Persicae (stir-fry) 30g, it is ground into 60 order coarse powder, employing carbon dioxide supercritical extraction method is extracted, extracting pressure 30～40Mpa, extraction temperature 30～40 DEG C, separator pressure 10～20Mpa, separator temperature 50～60 DEG C, disengaging time 2～4 hours, carbon dioxide flow is 40～50L per hour, obtain extracting solution；Take 60 DEG C～80 DEG C drying under reduced pressure of extracting solution, get dry extract；Take dry cream and add mannitol 150～200g, adopt high energy nanometer impact grinding to be ground into the mixing dried cream powder of particle diameter 200～300nm；Take mixing dried cream powder, dextrin 45～55g, crospolyvinylpyrrolidone 45～55g, cross-linking sodium carboxymethyl cellulose 35～45g, mix homogeneously, with 50～70% ethanol wet granulations, 60 DEG C～80 DEG C dry, additional carboxymethyl starch sodium 7～9g, granulate, suppress to obtain the peaceful sheet of arteria coronaria.
2. the preparation method of Chinese medicine according to claim 1, it is characterized in that taking Spora Lygodii 100g, Fructus Xanthii 100g, Radix Salviae Miltiorrhizae 112.5g, Caulis Spatholobi 112.5g, Sanguis Draxonis 25.5g, Semen Plantaginis 45g, Radix Angelicae Sinensis 45g, Radix Curcumae 45g, Radix Polygoni Multiflori Preparata 75g, Semen Persicae (stir-fry) 30g, be ground into 60 order coarse powder, employing carbon dioxide supercritical extraction method is extracted, extracting pressure 30～40Mpa, extraction temperature 30～40 DEG C, separator pressure 10～20Mpa, separator temperature 50～60 DEG C, disengaging time 2～4 hours, carbon dioxide flow is 40～50L per hour, obtains extracting solution；Take 60 DEG C～80 DEG C drying under reduced pressure of extracting solution, get dry extract；Take dry cream and add mannitol 150～200g, adopt high energy nanometer impact grinding to be ground into the mixing dried cream powder of particle diameter 200～300nm；Take mixing dried cream powder, dextrin 45～55g, crospolyvinylpyrrolidone 45～55g, cross-linking sodium carboxymethyl cellulose 35～45g, mix homogeneously, with 50～70% ethanol wet granulations, 60 DEG C～80 DEG C dry, additional carboxymethyl starch sodium 7～9g, granulate, suppress to obtain the peaceful sheet of arteria coronaria.
3. the preparation method of Chinese medicine according to claim 1, takes Spora Lygodii 100g, Fructus Xanthii 100g, Radix Salviae Miltiorrhizae 112.5g, Caulis Spatholobi 112.5g, Sanguis Draxonis 25.5g, Semen Plantaginis 45g, Radix Angelicae Sinensis 45g, Radix Curcumae 45g, Radix Polygoni Multiflori Preparata 75g, Semen Persicae (stir-fry) 30g, it is ground into 60 order coarse powder, adopts carbon dioxide supercritical extraction method to extract, extracting pressure 35Mpa, extraction temperature 35 DEG C, separator pressure 15Mpa, separator temperature 55 DEG C, disengaging time 3 hours, carbon dioxide flow is 45L per hour, obtains extracting solution；Take 70 DEG C of drying under reduced pressure of extracting solution, get dry extract；Take dry cream and add mannitol 175g, adopt high energy nanometer impact grinding to be ground into the mixing dried cream powder of particle diameter 200～300nm；Taking mixing dried cream powder, dextrin 50g, crospolyvinylpyrrolidone 50g, cross-linking sodium carboxymethyl cellulose 40g, mix homogeneously, with 60% ethanol wet granulation, 70 DEG C dry, additional carboxymethyl starch sodium 8g, and granulate suppresses to obtain the peaceful sheet of arteria coronaria.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410703480.8A CN105709163A (en) | 2014-11-30 | 2014-11-30 | Guan Maining tablet and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410703480.8A CN105709163A (en) | 2014-11-30 | 2014-11-30 | Guan Maining tablet and preparation method thereof |
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| Publication Number | Publication Date |
|---|---|
| CN105709163A true CN105709163A (en) | 2016-06-29 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201410703480.8A Pending CN105709163A (en) | 2014-11-30 | 2014-11-30 | Guan Maining tablet and preparation method thereof |
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| CN (1) | CN105709163A (en) |
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