CN105664156A - Vitamin antibody transfer factor compound oil emulsion for animals and preparing method thereof - Google Patents

Vitamin antibody transfer factor compound oil emulsion for animals and preparing method thereof Download PDF

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Publication number
CN105664156A
CN105664156A CN201610149323.6A CN201610149323A CN105664156A CN 105664156 A CN105664156 A CN 105664156A CN 201610149323 A CN201610149323 A CN 201610149323A CN 105664156 A CN105664156 A CN 105664156A
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China
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vitamin
antibody
transfer factor
oil emulsion
compound oil
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CN201610149323.6A
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Chinese (zh)
Inventor
王立明
王思琪
车建军
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JINAN DADONGNONG BIOTECHNOLOGY Co Ltd
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JINAN DADONGNONG BIOTECHNOLOGY Co Ltd
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Priority to CN201610149323.6A priority Critical patent/CN105664156A/en
Publication of CN105664156A publication Critical patent/CN105664156A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07—Retinol compounds, e.g. vitamin A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A61K31/51—Thiamines, e.g. vitamin B1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7135—Compounds containing heavy metals
    • A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/113—Multiple emulsions, e.g. oil-in-water-in-oil

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention discloses vitamin antibody transfer factor compound oil emulsion for animals and a preparing method thereof. The emulsion is prepared from, by weight, 3-5 parts of decavitamin, 4-6 parts of an animal antibody extracting solution, 5-7 parts of an animal transfer factor extracting solution, 7-12 parts of methionine and 9-10 parts of lysine. The decavitamin is prepared from, by weight, 8-12% of vitamin A, 10-20% of vitamin D3, 6-12% of vitamin E, 8-25% of vitamin B1, 8-15% of vitamin B2, 12-20% of vitamin B12, 4-15% of niacin, 10-15% of pantothenic acid, 7-15% of folic acid and the balance impurities. The vitamin antibody transfer factor compound oil emulsion for the animals contains a specific antibody for the animals, and is compounded with multiple vitamins and amino acid necessary to growth of the animals. While viral diseases are treated, nutrient substances are effectively supplemented to animal bodies, the immune function of the animals is effectively improved, recovery after the diseases is accelerated, and development of the environment-friendly and healthy breeding industry can be promoted effectively.

Description

Vitamin antibody transfer factor compound oil emulsion and preparation method thereof for a kind of animal
Technical field
The invention belongs to animal-breeding technical field, especially relate to a kind of animal vitamin antibody shift because ofSub-compound oil emulsion and preparation method thereof, belongs to biological technical field for animals.
Background technology
In animal farming industry, virus harm is one of factor of being concerned about the most. Cultivation person must the moment pairZoosis toxicity disease is prevented and controls. Animal virus infect the bird flu that causes, Marek's disease,Ewcastle disease, gumboro disease, infective bronchitis, infectious laryngotracheitis, encephalomyelitis etc.Every year bringing the economic loss of billions of units to aquaculture, is the formidable enemy of current aviculture development. How to haveEffect prevention and treatment poultry tumour and disease of viral infection be always puzzlement poultry disease prevention and control great difficult problem itOne. So far there is not yet the special poultry virus cause of disease of effectively killing of a kind of medicine energy. Therefore, need to grindMake a kind of new preparation, make it contain specific antibody, to contain necessary multiple the supporting one's family of growth of animalElement, amino acid. In treatment viral disease, effectively supplement animal body nutriment, effectively carryThe immunologic function of high animal, accelerates rehabilitation, promotes the development of green health aquaculture.
Summary of the invention
The present invention is directed to existing technical problem, provide a kind of animal vitamin antibody transfer factor compoundOil emu and preparation method thereof, can, in treatment viral disease, effectively supplement animal body nutritionMaterial, effectively improves the immunologic function of animal, accelerates rehabilitation, promotes sending out of green health aquacultureExhibition.
For achieving the above object, the invention provides following technical scheme: a kind of animal vitamin antibody turnsMove factor compound oil emulsion, it is characterized in that, it comprises the proportioning of following weight fraction: the compound dimension of 3-5 partRaw element and 4-6 part fowl antibody extract, 5-7 part fowl transfer factor extract, 7-12 part methionineWith 9-10 part lysine.
Further, as preferably, each material composition and the weight proportion of described B B-complex are:8-12% vitamin A, 10-20% neo dohyfral D3,6-12% vitamin E, 8-25% vitamin B1,8-15%Vitamin B2,12-20% cobalamin, 4-15% nicotinic acid, 10-15% pantothenic acid, 7-15% folic acid and otherFor impurity, and the percent of total of each content of material and impurity is 100%.
Further, as preferably, this compound oil emulsion is to add fat-soluble supporting one's family with water soluble vitaminIn element oil phase substance, fully stir mixed solution is fully dissolved each other, the light yellow compound oil breast of clarification obtainingAgent.
Further, as preferably, this compound oil emulsion is that the heating of liposoluble vitamin oil phase substance is dissolved each otherFor the brown yellow transparent liquid of clarification; Then, water soluble vitamin is made to clarification mixed liquor, stir oilPhase solution, slowly adds water-soluble mixed liquor in oil-phase solution by certain additive capacity, is uniformly mixedEvenly; Afterwards, continue to be uniformly mixed emulsion fluid temperature is down in 30 DEG C, slowly add antibodyExtract and fowl transfer factor extract, fully stirs mixed solution is fully dissolved each other, and obtains clarifyingLight yellow compound oil emulsion.
Further, as preferably, it is to adopt to spray that water-soluble mixed liquor is slowly added in oil-phase solutionMode adds, and the speed adding is 1.5-4.5ml/min.
Further, as preferably, described fowl adopts Yolk antibody extract, described fowl with antibody extractWith transfer factor extract be fowl spleen extract
In addition, the present invention also provides the system of a kind of animal vitamin antibody transfer factor compound oil emulsionPreparation Method, is characterized in that: it comprises the following steps:
(1) prepare liposoluble vitamin oil phase substance: liposoluble vitamin is dissolved according to certain ratioOrganic solvent, and heating, adopt ultrasonic wave to stir, and obtains liposoluble vitamin oil phase substance, treatsWith;
(2) prepare water soluble vitamin clarification mixed liquor: water soluble vitamin is molten according to certain ratioYu Shuizhong, adopts ultrasonic wave to stir, stand-by;
(3) the liposoluble vitamin oil phase substance of preparation in described step (1) is further heated and dissolved each otherFor the brown yellow transparent liquid of clarification; Then, stir described step (1) oil-phase solution, by described step(2) in, the water soluble vitamin of preparation slowly adds oil phase by certain additive capacity by water-soluble mixed liquorIn solution, be uniformly mixed; Afterwards, continue to be uniformly mixed emulsion make fluid temperature be down to 30 DEG C withIn, slowly add antibody extract and fowl transfer factor extract, fully ultrasonic wave stirring makes to mix moltenLiquid fully dissolves each other, and can obtain the light yellow compound oil emulsion of clarification.
Compared with prior art, the invention has the beneficial effects as follows:
Animal of the present invention contain fowl with specific antibody with vitamin antibody transfer factor compound oil emulsion andTransfer factor, simultaneously composite necessary multivitamin, the amino acid of growth of animal. Viral in treatmentWhen disease, effectively supplement animal body nutriment, effectively improve the immunologic function of animal, accelerate diseaseSick rehabilitation, can effectively promote the development of green health aquaculture.
Detailed description of the invention
Below in conjunction with the embodiment of the present invention, the technical scheme in the embodiment of the present invention is carried out clear, completeDescribe, obviously, described embodiment is only the present invention's part embodiment wholely, instead of allEmbodiment. Based on the embodiment in the present invention, those of ordinary skill in the art are not making creativenessThe every other embodiment obtaining under work prerequisite, belongs to the scope of protection of the invention.
Embodiment mono-
Vitamin antibody transfer factor compound oil emulsion for a kind of animal, it comprises joining of following weight fractionRatio: 4 parts of B B-complexes and 5 portions of fowl antibody extract, 6 portions of fowl transfer factor extract, 8 partsMethionine and 9 parts of lysines.
In the present embodiment, each material composition and the weight proportion of described B B-complex are: 10% dimensionRaw plain A, 13% neo dohyfral D3,10% vitamin E, 12% vitamin B1,8% vitamin B2,15% are supported one's familyElement B12,12% nicotinic acid, 10% pantothenic acid, 8% folic acid and other are impurity.
Embodiment bis-
Vitamin antibody transfer factor compound oil emulsion for a kind of animal, it comprises joining of following weight fractionRatio: 5 parts of B B-complexes and 4 portions of fowl antibody extract, 5 portions of fowl transfer factor extract, 10 partsMethionine and 9.5 parts of lysines.
In the present embodiment, each material composition and the weight proportion of described B B-complex are: 12% dimensionRaw plain A, 13% neo dohyfral D3,8% vitamin E, 10% vitamin B1,15% vitamin B2,18% are supported one's familyElement B12,10% nicotinic acid, 10% pantothenic acid, 7% folic acid and other are impurity.
Wherein, for the compound oil emulsion in embodiment mono-and embodiment bis-, its be by and water soluble vitaminRaw element adds in liposoluble vitamin oil phase substance, fully stirs mixed solution is fully dissolved each other, and obtainsClarify light yellow compound oil emulsion. This compound oil emulsion is that the heating of liposoluble vitamin oil phase substance is dissolved each otherFor the brown yellow transparent liquid of clarification; Then, water soluble vitamin is made to clarification mixed liquor, stir oilPhase solution, slowly adds water-soluble mixed liquor in oil-phase solution by certain additive capacity, is uniformly mixedEvenly; Afterwards, continue to be uniformly mixed emulsion fluid temperature is down in 30 DEG C, slowly add antibodyExtract and fowl transfer factor extract, fully stirs mixed solution is fully dissolved each other, and obtains clarifyingLight yellow compound oil emulsion. It is to adopt the mode of spraying that water-soluble mixed liquor is slowly added in oil-phase solutionAdd, and the speed adding is 1.5-4.5ml/min. Wherein, described fowl adopts yolk with antibody extractAntibody extract.
In addition, the present invention also provides the preparation of a kind of animal vitamin antibody transfer factor compound oil emulsionMethod, is characterized in that: it comprises the following steps:
(1) prepare liposoluble vitamin oil phase substance: liposoluble vitamin is dissolved in and is had according to certain ratioMachine solvent, and heating, adopt ultrasonic wave to stir, and obtains liposoluble vitamin oil phase substance, stand-by;
(2) prepare water soluble vitamin clarification mixed liquor: by water soluble vitamin according to described claim 2Ratio soluble in water, adopt ultrasonic wave stir, stand-by;
(3) by the liposoluble vitamin oil phase substance of preparation in described step (1) further heating dissolve each other forThe brown yellow transparent liquid of clarification; Then, stir described step (1) oil-phase solution, by described step (2)The water soluble vitamin of middle preparation slowly adds oil-phase solution by certain additive capacity by water-soluble mixed liquorIn, be uniformly mixed; Afterwards, continue to be uniformly mixed emulsion fluid temperature be down in 30 DEG C,Slowly add antibody extract and fowl transfer factor extract, fully ultrasonic wave stirs mixed solution is filledDivide and dissolve each other, can obtain the light yellow compound oil emulsion of clarification.
Animal of the present invention contains fowl specific antibody and fowl with vitamin antibody transfer factor compound oil emulsionUse transfer factor extract, simultaneously composite necessary multivitamin, the amino acid of growth of animal. ControllingWhen treating viral disease, effectively supplement animal body nutriment, effectively improve the immunologic function of animal,Accelerate rehabilitation, can effectively promote the development of green health aquaculture.
Although illustrated and described embodiments of the invention, for the ordinary skill in the art,Being appreciated that without departing from the principles and spirit of the present invention to carry out multiple to these embodimentVariation, amendment, replacement and modification, scope of the present invention is limited by claims and equivalent thereof.

Claims (7)

1. a vitamin antibody transfer factor compound oil emulsion for animal, is characterized in that, it comprises as followsThe proportioning of weight fraction: 3-5 part B B-complex and 4-6 part fowl antibody extract, 5-7 part fowl is with turningMove factor extract, 7-12 part methionine and 9-10 part lysine.
2. vitamin antibody transfer factor compound oil emulsion for a kind of animal according to claim 1,It is characterized in that: each material composition and the weight proportion of described B B-complex are: 8-12% vitaminA, 10-20% neo dohyfral D3,6-12% vitamin E, 8-25% vitamin B1,8-15% vitamin B2,12-20%Cobalamin, 4-15% nicotinic acid, 10-15% pantothenic acid, 7-15% folic acid and other are impurity, and each materialThe percent of total of content and impurity is 100%.
3. vitamin antibody transfer factor compound oil emulsion for a kind of animal according to claim 1,It is characterized in that: this compound oil emulsion is to add liposoluble vitamin oil phase substance with water soluble vitaminIn, fully stir mixed solution is fully dissolved each other, the light yellow compound oil emulsion of clarification obtaining.
4. vitamin antibody transfer factor compound oil emulsion for a kind of animal according to claim 2,It is characterized in that: this compound oil emulsion is that the heating of liposoluble vitamin oil phase substance is dissolved each other for the palm fibre of clarificationYellow transparent liquid; Then, water soluble vitamin is made to clarification mixed liquor, stir oil-phase solution, pressCertain additive capacity slowly adds water-soluble mixed liquor in oil-phase solution, is uniformly mixed; Afterwards,Continue to be uniformly mixed emulsion fluid temperature is down in 30 DEG C, slowly add antibody extract and fowl to useTransfer factor extract, fully stirs mixed solution is fully dissolved each other, and obtains the light yellow compound oil of clarificationEmulsion.
5. vitamin antibody transfer factor compound oil emulsion for a kind of animal according to claim 4,It is characterized in that: it is to adopt the mode of spraying to add that water-soluble mixed liquor is slowly added in oil-phase solution,And the speed adding is 1.5-4.5ml/min.
6. vitamin antibody transfer factor compound oil emulsion for a kind of animal according to claim 1,It is characterized in that: described fowl antibody extract adopts Yolk antibody extract, described fowl transfer factorAdopt fowl spleen extract.
7. multiple by vitamin antibody transfer factor according to a kind of animal described in claim 1-6 any oneThe preparation method who closes oil emu, is characterized in that: it comprises the following steps:
(1) prepare liposoluble vitamin oil phase substance: by the liposoluble vitamin described in claim 2Ratio according to described claim 2 is dissolved in organic solvent, and heating, adopts ultrasonic wave to stir,Obtain liposoluble vitamin oil phase substance, stand-by;
(2) prepare water soluble vitamin clarification mixed liquor: by water-soluble the supporting one's family described in claim 2Element is soluble in water according to the ratio of described claim 2, adopts ultrasonic wave to stir, stand-by;
(3) by the liposoluble vitamin oil phase substance of preparation in described step (1) further heating dissolve each other forThe brown yellow transparent liquid of clarification; Then, stir described step (1) oil-phase solution, by described step (2)The water soluble vitamin of middle preparation slowly adds oil-phase solution by certain additive capacity by water-soluble mixed liquorIn, be uniformly mixed; Afterwards, continue to be uniformly mixed emulsion fluid temperature be down in 30 DEG C,Slowly add antibody extract and transfer factor extract, fully ultrasonic wave stirs and makes mixed solution fully mutualMolten, can obtain the light yellow compound oil emulsion of clarifying.
CN201610149323.6A 2016-03-15 2016-03-15 Vitamin antibody transfer factor compound oil emulsion for animals and preparing method thereof Pending CN105664156A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102389036A (en) * 2011-10-13 2012-03-28 山东省健牧生物药业有限公司 Macroergic multivitamin-amino acid emulsion and preparation method thereof
CN104208673A (en) * 2013-09-30 2014-12-17 郑州后羿制药有限公司 Poultry antivirus composition, freeze-dried powder, preparation method and applications of the composition
CN104606675A (en) * 2015-01-24 2015-05-13 西安天星生物药业股份有限公司 Preparation method of poultry multi-linked specific egg yolk antibodies and transfer factors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102389036A (en) * 2011-10-13 2012-03-28 山东省健牧生物药业有限公司 Macroergic multivitamin-amino acid emulsion and preparation method thereof
CN104208673A (en) * 2013-09-30 2014-12-17 郑州后羿制药有限公司 Poultry antivirus composition, freeze-dried powder, preparation method and applications of the composition
CN104606675A (en) * 2015-01-24 2015-05-13 西安天星生物药业股份有限公司 Preparation method of poultry multi-linked specific egg yolk antibodies and transfer factors

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