CN105596642A - 一种用于促进骨折愈合的中药组合物 - Google Patents

一种用于促进骨折愈合的中药组合物 Download PDF

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CN105596642A
CN105596642A CN201610125596.7A CN201610125596A CN105596642A CN 105596642 A CN105596642 A CN 105596642A CN 201610125596 A CN201610125596 A CN 201610125596A CN 105596642 A CN105596642 A CN 105596642A
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rhizoma
radix
medicine composition
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刘晓云
王芳
刘晓静
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Abstract

本发明涉及一种用于促进骨折愈合的中药组合物，它是由下列重量配比的原料药物组成的：当归12-15g、川芎9-12g、熟地黄12-15g、芍药12-15g、没药5-10g、黄芪20-30g、土鳖虫5-10g、狗脊9-12g、骨碎补12-15g、杜仲12-15g、续断12-15g、香附9-12g、牛膝9-15g、苍术9-12g、威灵仙12-15g、地枫皮5-10g、千年健12-15g、煅自然铜9-12g、煅龙骨15-20g、煅牡蛎15-30g、甘草5-10g、三七粉3-6g。本发明的中药组合物具有活血通络、补益肝肾、接骨续筋、促进骨伤骨折快速愈合的功效，其配制简便、成本低，疗效显著，有效率达98.33％，治愈率达75％。

Description

一种用于促进骨折愈合的中药组合物
技术领域
本发明涉及一种传统草药的未确定结构的医用配制品，具体地说是一种用于促进骨折愈合的中药组合物。
背景技术
骨折是指骨结构的连续性完全或部分断裂。多见于儿童及老年人，中青年人也时有发生。病人常为一个部位骨折，少数为多发性骨折。经及时恰当处理，多数病人能恢复原来的功能，少数病人可遗留有不同程度的后遗症。对于骨折的治疗，目前治疗骨伤的主要方法是对骨折病人的患处固定，靠自然愈合。西医在治疗方面常采用复位、打石膏、超关节固定、手术下钢钉、抗菌消炎、预防感染的方案，无针对骨折的特效药物。骨折愈合是一个极其复杂的过程，涉及多种细胞和细胞因子的共同参与，目前，大多数研究只基于试验阶段，其作用机制以及各细胞因子间的相互作用关系尚未完全阐明。中药促进骨折愈合历史悠久，但现有的中药配方复杂，疗效差。
发明内容
本发明的目的就是为了克服上述现有的技术不足，根据中医理论，通过数年的药物筛选和反复临床验证，提供一种配伍合理，药源广，成本低，疗效显著，无毒副作用的用于促进骨折愈合的中药组合物，其具有活血通络、补益肝肾、接骨续筋、能促进骨伤骨折快速愈合。
本发明解决其技术问题所采用的技术方案是：一种用于促进骨折愈合的中药组合物，其特征在于它是由下列重量配比的原料药物组成的：当归12-15g、川芎9-12g、熟地黄12-15g、芍药12-15g、没药5-10g、黄芪20-30g、土鳖虫5-10g、狗脊9-12g、骨碎补12-15g、杜仲12-15g、续断12-15g、香附9-12g、牛膝9-15g、苍术9-12g、威灵仙12-15g、地枫皮5-10g、千年健12-15g、煅自然铜9-12g、煅龙骨15-20g、煅牡蛎15-30g、甘草5-10g、三七粉3-6g。
本发明的优选技术方案是：一种用于促进骨折愈合的中药组合物，其特征在于它是由下列重量的原料药物组成的：当归15g、川芎10g、熟地黄15g、芍药15g、没药5g、黄芪25g、土鳖虫8g、狗脊10g、骨碎补12g、杜仲15g、续断12g、香附9g、牛膝15g、苍术10g、威灵仙15g、地枫皮10g、千年健15g、煅自然铜10g、煅龙骨15g、煅牡蛎25g、甘草8g、三七粉6g。
本发明中药组合物是在传统中医理论和临床经验指导下，精选药物组方，原料成本低，用于促进骨折愈合，其疗效高，无毒副作用。本发明中的当归【性味】甘辛，温【归经】入心、肝、脾经【功能主治】补血和血，调经止痛，润燥滑肠。治月经不调，经闭腹痛，癥瘕结聚，崩漏；血虚头痛，眩晕，痿痹；肠燥便难，赤痢后重；痈疽疮窃，跌扑损伤。川芎【性味】辛，温【归经】归肝、胆、心包经【功能主治】活血行气，祛风止痛。用于月经不调，经闭痛经，癥瘕腹痛，胸胁刺痛，跌扑肿痛，头痛，风湿痹痛。熟地黄【性味】微温；甘【归经】归肝、肾经【功能主治】补血滋阴，益精填髓。用于肝肾阴虚，腰膝酸软，骨蒸潮热，盗汗遗精，内热消渴，血虚萎黄，心悸怔忡，月经不调，崩漏下血，眩晕，耳鸣，须发早白。芍药【性味】苦、酸、微寒、无毒【归经】入肺、脾、肝经【功能主治】主邪气腹痛，除血痹，破坚积寒热，疝瘕，止痛，利小便，益气。没药【性味】平；苦、辛【归经】归心、肝、脾经【功能主治】活血止痛，消肿生肌。用于外伤科跌打损伤，疮疡痈肿，瘀血阻滞诸痛证。黄芪【性味】甘，微温【归经】归脾、肺经【功能主治】补齐固表，托疮生肌。主治体虚自汗，久泻，脱肛，子宫脱垂，慢性肾炎，体虚浮肿，慢性溃疡，疮口久不愈合。土鳖虫【性味】咸，寒；有小毒【归经】归肝经【功能主治】破瘀血，续筋骨。用于筋骨折伤，瘀血经闭，癥瘕痞块。狗脊【性味】温；苦、甘【归经】归肝、肾经【功能主治】补肝肾，强腰膝，祛风湿。用于腰膝酸软，下肢无力，风湿痹痛。骨碎补【性味】苦；性温【归经】肝；肾经【功能主治】补肾强骨；活血止痛。主治肾虚腰痛；足膝痿弱；耳聋；牙痛；久泄；遗尿；跌打骨折及斑秃。杜仲【性味】温；甘【归经】归肝、肾经【功能主治】补肝肾，强筋骨，安胎。用于肾虚腰痛，筋骨无力，妊娠漏血，胎动不安；高血压。续断【性味】微温；苦、甘、辛【归经】归肝、肾经【功能主治】补肝肾，强筋骨，续折伤，止崩漏。用于腰膝酸软，风湿痹痛，崩漏，胎漏，跌扑损伤。香附【性味】平；辛、微苦、微甘【归经】归肝、脾、三焦经【功能主治】行气解郁，调经止痛。用于肝郁气滞，胸、胁、脘腹胀痛，消化不良，胸脘痞闷，寒疝腹痛，乳房胀痛，月经不调，经闭痛经。牛膝【性味】苦、酸，平【归经】归肝、肾经【功能主治】补肝肾，强筋骨，逐瘀通经，引血下行。用于腰膝酸痛，筋骨无力，经闭癥瘕，肝阳眩晕。苍术【性味】温；苦、辛【归经】归脾、胃经【功能主治】燥湿健脾，祛风散寒，明目。用于脘腹胀满，泄泻，水肿，脚气痿璧，风湿痹痛，风寒感冒，夜盲。威灵仙【性味】辛咸，温，有毒【归经】入膀胱经【功能主治】祛风湿，通经络，消痰涎，散癖积。治痛风、顽痹、腰膝冷痛，脚气，疟疾，癥瘕积聚，破伤风，扁桃体炎，诸骨鲠咽。地枫皮【性味】温；微辛、涩；有小毒【归经】归膀胱、肾经【功能主治】祛风除湿，行气止痛。用于风湿痹痛，腰肌劳损。千年健【性味】苦、辛，温【归经】归肝、肾经【功能主治】祛风湿，强筋骨，止痹痛。用于风湿痹痛，筋骨无力。自然铜【性味】辛，平【归经】归肝经【功能主治】散瘀，接骨，止痛。用于跌扑肿痛，筋骨折伤。煅自然铜：取净自然铜，照煅法(附录IID)煅至暗红，醋淬至表面呈黑褐色，光泽消失并酥松。每100kg自然铜，用醋30kg。龙骨【性味】甘涩，平【归经】入心、肝、肾、大肠经【功能主治】镇惊安神，敛汗固精，止血涩肠，生肌敛疮。治惊痫癫狂，怔忡健忘，失眠多梦，自汗盗汗，遗精淋浊，吐衄便血，崩漏带下，泻痢脱肛，溃疡久不收口。煅龙骨：取刷净的龙骨，在无烟的炉火上或坩埚内煅红透，取出，放凉，碾碎。牡蛎【性味】咸，微寒【归经】归肝、胆、肾经【功能主治】重镇安神，潜阳补阴，软坚散结。用于惊悸失眠，眩晕耳鸣，瘰疬痰核，癥瘕痞块。煅牡蛎收敛固涩。用于自汗盗汗，遗精崩带，胃痛吞酸。甘草【性味】甘，平【归经】归心，脾，肺，胃经【功能主治】有补脾益气，润肺止咳，清热解毒，缓解止痛，缓和药性的功效。三七粉【性味】甘、味苦，温【归经】归肝、胃经【功能主治】散瘀止血，消肿定痛。用于咯血，吐血，衄血，便血，崩漏，外伤出血，胸腹刺痛，跌扑肿痛等。上述诸药合用，具有活血通络、补益肝肾、接骨续筋、促进骨伤骨折快速愈合的功效，对骨折愈合达到标本兼治的目的。
本发明的组合物遵循中医的处方用药原则，采用天然的中药原料，配制简便、药源广、成本低。其中除三七粉粉剂冲服外，其他原料药物采用水煎服用，经临床应用验证，其疗效显著，作用可靠，药性平和，未出现毒副作用，总有效率98.33％，治愈率为75％。
具体实施方式
实施例1：一种用于促进骨折愈合的中药组合物，它是由下列重量的原料药物组成的：当归12g、川芎9g、熟地黄12g、芍药12g、没药5g、黄芪20g、土鳖虫5g、狗脊9g、骨碎补12g、杜仲12g、续断12g、香附9g、牛膝9g、苍术9g、威灵仙12g、地枫皮5g、千年健12g、煅自然铜9g、煅龙骨15g、煅牡蛎15g、甘草5g、三七粉3g。
实施例2：一种用于促进骨折愈合的中药组合物，它是由下列重量的原料药物组成的：当归15g、川芎12g、熟地黄15g、芍药15g、没药10g、黄芪30g、土鳖虫10g、狗脊12g、骨碎补15g、杜仲15g、续断15g、香附12g、牛膝15g、苍术12g、威灵仙15g、地枫皮10g、千年健15g、煅自然铜12g、煅龙骨20g、煅牡蛎30g、甘草10g、三七粉6g。
实施例3：一种用于促进骨折愈合的中药组合物，它是由下列重量的原料药物组成的：当归12g、川芎12g、熟地黄12g、芍药15g、没药5g、黄芪30g、土鳖虫5g、狗脊12g、骨碎补12g、杜仲15g、续断12g、香附12g、牛膝9g、苍术12g、威灵仙12g、地枫皮10g、千年健12g、煅自然铜12g、煅龙骨15g、煅牡蛎30g、甘草5g、三七粉5g。
实施例4：一种用于促进骨折愈合的中药组合物，它是由下列重量的原料药物组成的：当归15g、川芎10g、熟地黄15g、芍药15g、没药5g、黄芪25g、土鳖虫8g、狗脊10g、骨碎补12g、杜仲15g、续断12g、香附9g、牛膝15g、苍术10g、威灵仙15g、地枫皮10g、千年健15g、煅自然铜10g、煅龙骨15g、煅牡蛎25g、甘草8g、三七粉6g。
本发明实施例中的中药组合物，除三七粉外，其它中药原料药物按常规的水煎法制取药剂。具体方法如下：取本发明组合物，除三七粉外，其它的中药原料药物放入容器中，先加水浸泡，加冷水漫过药面，浸泡20～30分钟，再加水没过药面约15厘米；进行第一次煎煮，先用武火煎煮，煮沸后用文火煎煮20～30分钟，滤出取药液汁200ml；第二煎煮，加水没过药面约10厘米，水沸后煎煮20～25分钟，滤出取药液汁200ml。两次煎煮取得药液汁合并备用。三七粉剂，以备冲服。
一种用于促进骨折愈合的中药组合物的临床疗效总结：
一、一般性资料：本用于促进骨折愈合的中药组合物应用于临床观察病180例，其中男82例，女98例，年龄10～70岁。
二、诊断标准：
骨折的特有体征
1、畸形：骨折端移位可使患肢外形发生改变，主要表现为缩短、成角、延长。
2、异常活动：正常情况下肢体不能活动的部位，骨折后出现不正常的活动。
3、骨擦音或骨擦感：骨折后两骨折端相互摩擦撞击，可产生骨擦音或骨擦感。
以上三种体征只要发现其中之一即可确诊，但未见此三种体征者也不能排除骨折的可能，如嵌插骨折、裂缝骨折。一般情况下不要为了诊断而检查上述体征，因为这会加重损伤。
检查：
1.X线检查：凡疑为骨折者应常规进行X线拍片检查，可显示临床上难以发现的不完全性骨折、深部的骨折、关节内骨折和小的撕脱性骨折等，即使临床上已表现为明显骨折者，X线拍片检查也是必需的，可以了解骨折的类型和具体情况，对治疗具有指导意义。
2.CT检查：对于骨折不明确但又不能排除者、脊柱骨折有可能压迫脊髓神经根者及复杂骨折者均可行CT检查。三维CT重建可以更直观便捷地进行骨折分型，对治疗方案选择帮助很大，目前临床上常用。
3.MRI检查：虽然显示骨折线不如CT检查，但对于脊髓神经根及软组织损伤的显示有独特优点，目前已广泛用于脊柱骨折的检查。
三、用法用量：临床应用时，组合物中的组分、用量根据患者的体重、年龄及症状酌情增减。7剂为一疗程，一天一剂，水煎两遍取汁约400ml，分早、晚两次饭前半小时温热服用。三七粉粉剂同水剂，分早、晚两次饭前服用。
四、疗效标准：
1、治愈：受损处的疼痛、肿胀等症状消失，通过X线对骨折处进行拍片检查，发现受损部位已完全愈合。
2、显效：受损处的疼痛、肿胀等症状消失，通过X线对骨折处进行拍片检查，发现受损部位已明显好转，已基本愈合。
3、无效：受损处的疼痛、肿胀等症状改善缓慢，通过X线对骨折处进行拍片检查，发现受损部位愈合状况较差，愈合缓慢。
五、治疗效果：临床观察病例中，服药1-5个疗程，治愈135例，有效42例，无效3例。治疗期间未发生毒副作用。
六、典型病例：
1、王某，男，40岁，因车祸，造成左右臂双侧左臂桡骨骨折。治疗：手法拔伸复位，夹缚固定，服用本发明的中药组合物，一疗程后拆除外固定，肿胀消除，肌肉恢复弹性，二个疗程后，可进行曲伸、取物等锻炼，关节活动自如，三个疗程后臂力恢复，痊愈。
2、赵某，女，50岁，患者从高处跌落，骨折，经X线片检查，发现左锁骨中外1/3处骨折，断端错位重叠，右外踝骨折，断端对位线可。诊断为：左锁骨骨折，右外踝骨折伴三角韧带损伤。住院经手术后服用本发明的中药组合物，服用两个疗程后，X线检查，左肱骨中段骨折部位无移位，有少量骨痂生长；服用三疗程后，X线检查，左肱骨中段骨折部位有明显骨痂生长，骨折线开始模糊；继续服用至两个疗程，X线检查，左肱骨中段骨折部位有大量骨痂生长，骨折线模糊并消失，符合骨折临床愈合标准，恢复正常工作和家务劳动。
3、钱某，女，25岁，患者左尺、挠骨闭合性骨折，进行手法复位，小夹板固定，服用本发明的中药组合物，服用一疗程后肿痛消除，两疗程后X线可见原始骨痂生成，五个疗程可见骨小梁通过骨折线。X线检查，骨痂生长，骨折线模糊并消失。符合骨折临床愈合标准，下地负重行走，并逐渐恢复正常。

Claims (2)

1.一种用于促进骨折愈合的中药组合物，其特征在于它是由下列重量配比的原料药物组成的：当归12-15g、川芎9-12g、熟地黄12-15g、芍药12-15g、没药5-10g、黄芪20-30g、土鳖虫5-10g、狗脊9-12g、骨碎补12-15g、杜仲12-15g、续断12-15g、香附9-12g、牛膝9-15g、苍术9-12g、威灵仙12-15g、地枫皮5-10g、千年健12-15g、煅自然铜9-12g、煅龙骨15-20g、煅牡蛎15-30g、甘草5-10g、三七粉3-6g。
2.根据权利要求1所述的一种用于促进骨折愈合的中药组合物，其特征在于它是由下列重量的原料药物组成的：当归15g、川芎10g、熟地黄15g、芍药15g、没药5g、黄芪25g、土鳖虫8g、狗脊10g、骨碎补12g、杜仲15g、续断12g、香附9g、牛膝15g、苍术10g、威灵仙15g、地枫皮10g、千年健15g、煅自然铜10g、煅龙骨15g、煅牡蛎25g、甘草8g、三七粉6g。
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CN101623415A (zh) * 2009-08-07 2010-01-13 葛超顺 一种治疗骨折骨伤的中药制剂

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CN101623415A (zh) * 2009-08-07 2010-01-13 葛超顺 一种治疗骨折骨伤的中药制剂

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