CN105582090A - 一种用于治疗酒精性股骨头坏死的药物 - Google Patents
一种用于治疗酒精性股骨头坏死的药物 Download PDFInfo
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Abstract
本发明涉及一种用于治疗酒精性股骨头坏死的药物，它是由以下重量配比的原料药材制备而成：远志8份、荷叶3份、黄连6份、杜仲8份、牛膝8份、蜂房6份、苦木9份、海金沙6份、红花6份、红芪8份。本发明运用：远志安神益智；荷叶升发清阳；黄连泻火解毒；杜仲、牛膝补肝肾，强筋骨，逐瘀通经；蜂房祛风止痛；苦木清热祛湿解毒；海金沙清利湿热，通淋止痛；红花活血散瘀；红芪托毒生肌。诸药合用，共奏安神益智、补肝肾强筋骨、祛风止痛、祛湿解毒之功。达到治疗酒精性股骨头坏死的目的。临床实验证明，本发明能够安全有效治疗酒精性股骨头坏死。
Description
技术领域
本发明涉及一种中药，具体涉及一种用于治疗酒精性股骨头坏死的药物。
背景技术
股骨头坏死又称股骨头无菌性坏死，或股骨头缺血性坏死，是由于多种原因导致的股骨头局部血运不良，从而引起骨细胞进一步缺血、坏死、骨小梁断裂、股骨头塌陷的一种病变。酒精性股骨头坏死就是因为大量酗酒而引起的一种股骨头坏死。简单的说是脂类代谢异常导致的结果，临床研究表明长期大量饮酒者，血脂明显升高，致使肝内脂类的清理效能降低而致脂肪肝。
酗酒之所以会对股骨头产生破坏作用，是因为酒精会增加血液的粘稠度，股骨头这个位置血运本来就不好，血液的粘稠度如果还不断升高，这个位置的微循环就容易出现问题，进一步出现坏死症状。大量吸烟也会造成血管的痉挛，降低血供，诱发股骨头的坏死。
早期酒精性股骨头坏死患者常感患肢无力，髋关节疼痛，慢性钝痛或剧痛，夜间和劳累加重，可放射到膝关节、大腿内侧、腹股沟等。到了中晚期酒精性股骨头坏死时，患者出现髋关节功能活动受限，以外展、内旋及屈曲等功能主。下蹲、穿鞋困难、行走步幅小、跛行、4字实验、托马氏征阳性及患侧下肢肌肉萎缩。
酒精性股骨头坏死的X线表现：
1.早期股骨头外形完整，骨性关节面光滑，骨密度无明显改变，仅见骨小梁梳松变粗，但临床上无典型的临床症状及体症，并且在酒精性股骨头坏死的早期X线光片并不能显示股骨头坏死，所以早期光靠X线光片诊断股骨头坏死比较困难，则需要患者做ECT、MRI等检查来辅助诊断。
2.中晚期在骨性关节面的下方出现了2-4mm宽的新月形透明带，即“新月征”。股骨头顶部或全股骨头的密度增高，但有密度减低及囊状透光区。死骨为楔形及半月形，其下有一密度较高的新生骨带。股骨头塌陷变形，呈蘑菇状。骨形关节面破裂，凸凹不平，关节间隙变窄，患髋呈半脱位。常伴有骨性关节炎。
中医认为与股骨头坏死病变关系最为密切的为肝、脾、肾三脏。肾为先天之本，主骨生髓，肾健则髓充，髓满则骨坚。反之，则髓枯骨萎，失去应用的再生能力。肝主筋藏血，与肾同源，两藏荣衰与共，若肝脏受累，藏血失司，不能正常调节血量，“心主血，肝藏之，人动则运于诸经，人静则血归于肝脏。”若血液藏运不周，营养不济，亦是造成缺血性股骨头坏死的重要因素。脾胃为后天这本，万物生化之源，使脾健胃和，则不谷腐熟，化气化血，以行营卫，若脾胃失健运，生化气血无源，则筋骨肌肉皆无气以生。
本发明所涉及药材均可见记载于《中国药典》。
发明内容
本发明旨在提供一种用于治疗酒精性股骨头坏死的药物，通过选择合适的药材及其配比，达到安全有效治愈酒精性股骨头坏死的目的。
为了达到上述目的，本发明采用以下技术方案：
一种用于治疗酒精性股骨头坏死的药物，其特征在于，它是由以下重量配比的原料药材制备而成：远志8份、荷叶3份、黄连6份、杜仲8份、牛膝8份、蜂房6份、苦木9份、海金沙6份、红花6份、红芪8份。
下面结合中药学理论说明本发明有益效果：
发明人认为，本病由于患者长期饮酒无度、嗜欲不节，以致脉络张弛失调、周身血行受阻，最终导致骨内髓失所养；或因素体肝肾亏虚，肝虚不能主筋藏血、肾虚不能藏精主骨，而过量饮酒使营卫失调加重，阻碍气血滋养筋骨，致生本病。
本发明运用：远志安神益智；荷叶升发清阳；黄连泻火解毒；杜仲、牛膝补肝肾，强筋骨，逐瘀通经；蜂房祛风止痛；苦木清热祛湿解毒；海金沙清利湿热，通淋止痛；红花活血散瘀；红芪托毒生肌。诸药合用，共奏安神益智、补肝肾强筋骨、祛风止痛、祛湿解毒之功。达到治疗酒精性股骨头坏死的目的。
下面结合临床实验数据说明本发明的有益效果：
1、一般资料
纳入标准：①年龄18到60岁；②诊断为股骨头坏死，且有长期、大量饮酒史；③无经济条件手术、惧怕手术或合并疾病无法手术治疗者，需行保守治疗。
排除标准：①先天性髋关节发育不良者；②长期使用激素类药物、遭受外伤或其他原因引起ONFH者。本研究获得医院伦理委员通过，患者均签署知情同意书。
发明人2012年1月-2014年1月间共收集60例酒精性股骨头坏死患者。随机分为：治疗组30例，对照组30例。治疗组男12例，女18例；年龄18～57岁；病程6个月～12年。对照组男11例，女19例；年龄18～58岁；病程6个月～13年。两组患者在性别、年龄、病程及症状积分等方面比较，差异无统计学意义(两组性别、年龄、病程等资料无显著性差异，具有可比性。
2、治疗方法
治疗组口服本发明按照具体实施例3制得的胶囊，每日3次。治疗3个月。
对照组口服仙灵骨葆胶囊，按其说明书服用，治疗3个月。
3、疗效标准与治疗结果
3.1疗效标准
优:疼痛完全消失,髋功能恢复正常,X线好转1级以上者。
良:疼痛轻度或偶尔,髋功能轻度受限,X线稳定或稍有恢复。
可:疼痛中度需止疼药,髋功能一般受限,X线无加重趋势。
差:剧痛,髋功能重度受限、扶拐,X线有恶化。
3.2治疗统计结果见表1。
表1两组疗效比较
可见，本发明制得的药物能够安全有效治疗酒精性股骨头坏死。
具体实施方式
为了更好地理解和实施本发明，下面结合具体实施例进一步说明本发明。
实施例1
称取：远志8克、荷叶3克、黄连6克、杜仲8克、牛膝8克、蜂房6克、苦木9克、海金沙6克、红花6克、红芪8克；加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩至120克，即得符合正常成人一天用量的煎剂。
用于治疗酒精性股骨头坏死。口服，每日服用一次。
实施例2
称取：远志8克、荷叶3克、黄连6克、杜仲8克、牛膝8克、蜂房6克、苦木9克、海金沙6克、红花6克、红芪8克；加10倍量水，煎煮2小时，过滤；滤渣加8倍量水，煎煮1.5小时，过滤；合并滤液，浓缩，干燥，包装，即得符合正常成人一天用量的散剂。
用于治疗酒精性股骨头坏死。口服，每日分早晚两次服用。
实施例3
称取：远志8克、荷叶3克、黄连6克、杜仲8克、牛膝8克、蜂房6克、苦木9克、海金沙6克、红花6克、红芪8克；加6倍量水，煎煮3次，每次煎煮1小时，合并煎煮液，浓缩，干燥，装入胶囊壳，即得符合正常成人一天用量的胶囊剂。
用于治疗酒精性股骨头坏死。口服，每日分早中晚三次服用。
Claims (4)
1.一种用于治疗酒精性股骨头坏死的药物，其特征在于，它是由以下重量配比的原料药材制备而成：远志8份、荷叶3份、黄连6份、杜仲8份、牛膝8份、蜂房6份、苦木9份、海金沙6份、红花6份、红芪8份。
2.如权利要求1所述的一种用于治疗酒精性股骨头坏死的药物，其特征在于，其制备方法为：称取：远志8份、荷叶3份、黄连6份、杜仲8份、牛膝8份、蜂房6份、苦木9份、海金沙6份、红花6份、红芪8份；加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩至120份，即得煎剂；上述份均是指重量份。
3.如权利要求1所述的一种用于治疗酒精性股骨头坏死的药物，其特征在于，其制备方法为：称取：远志8份、荷叶3份、黄连6份、杜仲8份、牛膝8份、蜂房6份、苦木9份、海金沙6份、红花6份、红芪8份；加10倍量水，煎煮2小时，过滤；滤渣加8倍量水，煎煮1.5小时，过滤；合并滤液，浓缩，干燥，包装，即得散剂；上述份均是指重量份。
4.如权利要求1所述的一种用于治疗酒精性股骨头坏死的药物，其特征在于，其制备方法为：称取：远志8份、荷叶3份、黄连6份、杜仲8份、牛膝8份、蜂房6份、苦木9份、海金沙6份、红花6份、红芪8份；加6倍量水，煎煮3次，每次煎煮1小时，合并煎煮液，浓缩，干燥，装入胶囊壳，即得胶囊剂；上述份均是指重量份。
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1515306A (zh) * | 2003-08-29 | 2004-07-28 | 石永龙 | 一种治疗股骨头坏死的药物 |
| CN101773531A (zh) * | 2010-03-05 | 2010-07-14 | 王春玉 | 一种治疗骨质增生、股骨头坏死的药酒 |
| CN102600430A (zh) * | 2012-03-31 | 2012-07-25 | 沈庆坡 | 一种治疗股骨头坏死的药剂 |
| CN102688452A (zh) * | 2012-05-25 | 2012-09-26 | 韦标方 | 治疗酒精性股骨头坏死的中药、膏药、其制备方法及应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1515306A (zh) * | 2003-08-29 | 2004-07-28 | 石永龙 | 一种治疗股骨头坏死的药物 |
| CN101773531A (zh) * | 2010-03-05 | 2010-07-14 | 王春玉 | 一种治疗骨质增生、股骨头坏死的药酒 |
| CN102600430A (zh) * | 2012-03-31 | 2012-07-25 | 沈庆坡 | 一种治疗股骨头坏死的药剂 |
| CN102688452A (zh) * | 2012-05-25 | 2012-09-26 | 韦标方 | 治疗酒精性股骨头坏死的中药、膏药、其制备方法及应用 |
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