CN105559947A - Preparation method of porous implant filled with O-intersecting lines units - Google Patents

Preparation method of porous implant filled with O-intersecting lines units Download PDF

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Publication number
CN105559947A
CN105559947A CN201510940064.4A CN201510940064A CN105559947A CN 105559947 A CN105559947 A CN 105559947A CN 201510940064 A CN201510940064 A CN 201510940064A CN 105559947 A CN105559947 A CN 105559947A
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CN
China
Prior art keywords
porous
porous implant
implant
dimensional
entity
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CN201510940064.4A
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Chinese (zh)
Inventor
张春雨
孙学通
陈贤帅
林志生
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广州中国科学院先进技术研究所
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Priority to CN201510940064.4A priority Critical patent/CN105559947A/en
Publication of CN105559947A publication Critical patent/CN105559947A/en

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/28Bones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/32Joints for the hip
    • A61F2/36Femoral heads ; Femoral endoprostheses
    • A61F2/3609Femoral heads or necks; Connections of endoprosthetic heads or necks to endoprosthetic femoral shafts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/28Bones
    • A61F2002/2825Femur
    • A61F2002/2832Femoral neck
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/28Bones
    • A61F2002/2835Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material

Abstract

The invention provides a preparation method of a porous implant filled with O-intersecting lines units. The preparation method comprises the following steps: drawing a three-dimensional model of the O-intersecting lines units, controlling the bore diameter, wall thickness and porosity of the three-dimensional model according to the given specific dimension so as to generate a unit structure cell body, carrying out array copying operation on the unit structure cell body, thus obtaining a space porous network body, introducing in a femoral three-dimensional surface model, scaling the model to reach the proportion actually needed, carrying out cutting and Boolean operation on the porous network body and the femoral three-dimensional surface, thus obtaining a porous main body part, drawing the femoral steam end and a bolt positioning hole part by utilizing three-dimensional modeling, combing the porous main body part to enable the porous main body part to form a single-output porous implant body, saving the single-output porous implant body into an output format file and transmitting the file to layering software, adding with a bottom surface support, printing the porous implant body by adopting a 3D printer, clearing a substrate plate, taking out the porous implant, carrying out sand blasting treatment on the porous implant, and packaging the porous implant. With the adoption of the preparation method, units which are regular and uniform and having no closure can be generated, and the stressing uniformity is guaranteed.

Description

A kind of preparation method of porous implant of being filled by O-intersecting lines unit
Technical field
Category belonging to the present invention is biological medical instruments field, relates to a kind of preparation method of porous implant, is specifically related to a kind of preparation method of porous implant of being filled by O-intersectinglines (column intersection line) unit.
Background technology
Long bone the longest in human body is femur, and it can divide and is integrated two ends, and similar bone is as humerus etc.Femur is also known as Thigh bone, and it is mainly used in the trunk, pelvis etc. of support human body, and be maximum bone that bears a heavy burden, be all extremely important in numerous animals such as the mankind.
But, the disease bad due to some or wound etc. cause femur to rupture and cause large-area Cranial defect, and when cannot be healed by autologous tissue, then need to consider bone collection, particularly for some old peoples, best Therapeutic Method is exactly artificial bone or replacement joint, can avoid the situation of postoperative generation Avascular Necrosis Of Femur Head like this.Femur supports and maximum skeletal structure that bears a heavy burden as in human body, must be paid attention to.
The technology of current existing a lot of bone collection.Use solid metal bone collection traditionally, although cost is low, but implant deadweight is excessive, patient can be made not feel well, and it can cause obvious stress capture-effect, this stimulation that will primary bone tissue caused well can not to be subject to external force, cause it to soften, moreover, also because solid metal implant fails to provide enough space for inducing the regrowth of original structure, primary bone tissue finally may be caused to come off, and therefore this technology not can solve Cranial defect problem; There is degradable biomaterial in addition as the graft technology of bone implant, this degradable biomaterial can adapt to the primary structure of host, obvious rejection can not be produced, but, its intensity is not enough unavoidably, and as the implant of femur structure, based on the heavy burden effect of femur, need implant to have enough intensity, therefore this employing degradable biomaterial neither optimum selection as bone implant.
Tradition is main still based on certain algorithm and image processing techniques for the bone trabecular method for designing of porous, by gathering human bone microstructure image, extract peripheral outline, the data obtained are carried out interpolation and are repaired generating vector diagram, finally each layer data are carried out summation and obtain three-dimensional porous structure.There is closed cell in this design, and closed cell will be not suitable for the regeneration of osseous tissue and grow into unavoidably, because for femur model, ensure that the connection between bone trabecula is very important, in addition, this mode is difficult to the unified unit of create-rule, is therefore difficult to ensure stressed uniformity.
Summary of the invention
In view of this, the present invention is intended to propose Improving ways in the shortcoming of traditional bone implant and the difficulty of bone trabecula design, it is mainly by a kind of porous implant of being filled by O-intersectinglines unit of design, and carry out Design and manufacture for femur model, in order to realize Simple Design and the manufacture of bone implant, finally for femur implanted prosthetics provides good medical reference to be worth.
The present invention is solved the problem by following technological means:
A kind of porous implant of being filled by O-intersectinglines unit, it is mainly towards femoral stem, comprise femur pommel, porous bodies part and screw pilot hole position, described femur pommel is for locating described porous implant, described screw pilot hole position is used for fixing implant and host, the through porous network entity of three-dimensional that described porous bodies part is filled primarily of O-intersectinglines unit, described porous network entity be by O-intersectinglines unit cylinder to pass through mutually in space intersect the hollow out entity that scans, the aperture of described porous network entity is 400-1000 μm, unit wall thickness is 80-120 μm, porosity is 55%-85%.
Further, described hollow out entity forms by the O-intersectinglines unit face of cylinder is orthogonal, linearly stacking between two in space.
Further, described porous implant is made primarily of human implantable metal material, preferred pure titanium metal, titanium alloy, rustless steel and vitallium.
Further, described O-intersectinglines unit form is that second order cylinder passes through cellular construction mutually or three rank cylinders pass through cellular construction mutually.
Preferably, when described O-intersectinglines unit form is second order cylinder units, described perforated grill entity aperture is 500 μm, pipeline wall thickness is 100 μm, porosity is 72%; When described O-intersectinglines unit form is three rank cylinder units, described perforated grill entity aperture is 500 μm, pipeline wall thickness is 100 μm, porosity is 69%.
Preferably, described femur pommel, described porous bodies part and described screw pilot hole position are linked to be an entirety, do not need to assemble direct disposal molding in addition.
The preparation method of porous implant of the present invention comprises the following steps:
S1. Three-dimensional Design Software is utilized to draw the threedimensional model of O-intersectinglines unit on computers, the threedimensional model face of cylinder is orthogonal between two in space, linearly stacking, by given its aperture of concrete size Control, wall thickness and porosity, generation unit structure cell entity;
S2. array processing is copied to unit structure cell entity, obtain space porous network entity;
S3. the femur three-dimensional surface model that reverse-engineering obtains is directed through, to scaling of model to the ratio of actual needs;
S4. cutting is carried out to porous network entity and femur three-dimension curved surface and Boolean calculation operates, obtain porous bodies part;
S5. draw femur pommel and screw pilot hole position by three-dimensional modeling, and merge porous bodies part and make it to become single output porous implant entity;
S6. porous implant entity preserved into output format file and transfer in delamination software, adding bottom supporting;
S7. open fiber selectivity laser fusion equipment metal material 3D printer, porous implant entity is printed;
S8. clear up substrate, take out with the porous implant that 3D prints by shovel file;
S9. blasting treatment is carried out to porous implant, make its any surface finish;
S10. porous implant is encapsulated.
Preferably, in step S1, described Three-dimensional Design Software is solidworks or pro-eUG.
Preferably, in step S6, described output format file is stl, and described delamination software is ontofab.
Preferably, in step S7, described fiber selectivity laser fusion equipment metal material 3D printer model is SLM125HL.
Further, in step S7, described print parameters is set as: pure titanium density is 4.55g/cm3, laser spot diameter d=80-85 μm, sweep span h=100-200 μm, power P=70-100W, scan velocity V=100-500mm/s, paving powder thickness t=40-70 μm.
The invention provides porous implant of being filled by O-intersectinglines unit and preparation method thereof, compared with prior art, thus hollow out entity stacking porous network structure close to bone structure, there is high porosity, high connected ratio and larger contact surface area, applicable area of new bone is grown into and the circulation of nutritive issue liquid, loose structure and pure titanium material provide enough high strength also to avoid too many stress shielding, highly interconnected through hole structure can provide Bone Ingrowth widely, the initial stability that ideal material makes coefficient of friction provide good, possess the potentiality of good implant, there is considerable clinical medical prospect, the preparation method of porous implant is more reliably feasible, is convenient to adopt 3D to print and processes.
Accompanying drawing explanation
Fig. 1 is second order O-intersectinglines cell schematics;
Fig. 2 is three rank O-intersectinglines cell schematics;
Fig. 3 is second order O-intersectinglines element stack schematic diagram;
Fig. 4 is three rank O-intersectinglines element stack schematic diagrams;
Fig. 5 is the porous implant schematic diagram of being filled by O-intersectinglines unit.
Detailed description of the invention
For enabling above-mentioned purpose of the present invention, feature and advantage become apparent more, are described in detail to technical scheme of the present invention below in conjunction with accompanying drawing and specific embodiment.
Please refer to Fig. 1, Fig. 3 and Fig. 5, a kind of porous implant of being filled by O-intersectinglines unit, it is mainly towards femoral stem, comprise femur pommel, porous bodies part and screw pilot hole position, described femur pommel is for locating described porous implant, described screw pilot hole position is used for fixing implant and host, the through porous network entity of three-dimensional that described porous bodies part is filled primarily of O-intersectinglines unit, described O-intersectinglines unit form is that second order cylinder passes through cellular construction mutually, described porous network entity be by O-intersectinglines unit cylinder to pass through mutually in space intersect the hollow out entity that scans, described hollow out entity is orthogonal between two in space by the O-intersectinglines unit face of cylinder, linearly stackingly to form, described perforated grill entity aperture is 500 μm, pipeline wall thickness is 100 μm, porosity is 72%, described porous implant is made primarily of human implantable metal material, preferred pure titanium metal, titanium alloy, rustless steel and vitallium, described femur pommel, described porous bodies part and described screw pilot hole position are linked to be an entirety, do not need to assemble direct disposal molding in addition.
Please refer to Fig. 2, Fig. 4 and Fig. 5, a kind of porous implant of being filled by O-intersectinglines unit, it is mainly towards femoral stem, comprise femur pommel, porous bodies part and screw pilot hole position, described femur pommel is for locating described porous implant, described screw pilot hole position is used for fixing implant and host, the through porous network entity of three-dimensional that described porous bodies part is filled primarily of O-intersectinglines unit, described O-intersectinglines unit form is that three rank cylinders pass through cellular construction mutually, described porous network entity be by O-intersectinglines unit cylinder to pass through mutually in space intersect the hollow out entity that scans, described hollow out entity is orthogonal between two in space by the O-intersectinglines unit face of cylinder, linearly stackingly to form, described perforated grill entity aperture is 500 μm, pipeline wall thickness is 100 μm, porosity is 69%, described porous implant is made primarily of human implantable metal material, preferred pure titanium metal, titanium alloy, rustless steel and vitallium, described femur pommel, described porous bodies part and described screw pilot hole position are linked to be an entirety, do not need to assemble direct disposal molding in addition.
The preparation method of porous implant of the present invention comprises the following steps:
S1. Three-dimensional Design Software is utilized to draw the threedimensional model of O-intersectinglines unit on computers, the threedimensional model face of cylinder is orthogonal between two in space, linearly stacking, by given its aperture of concrete size Control, wall thickness and porosity, generation unit structure cell entity;
Specific as follows: to use solidworks Three-dimensional Design Software on computers, draw O-intersectinglines second order or three rank column intersection line space lattice unit, dimensioning makes that pore size is 500 μm, wall thickness size is 100 μm, porosity is 65%-75%;
S2. array processing is copied to unit structure cell entity, obtain space porous network entity;
S3. the femur three-dimensional surface model that reverse-engineering obtains is directed through, to scaling of model to the ratio of actual needs;
S4. cutting is carried out to porous network entity and femur three-dimension curved surface and Boolean calculation operates, obtain porous bodies part;
S5. draw femur pommel and screw pilot hole position by three-dimensional modeling, and merge porous bodies part and make it to become single output porous implant entity;
S6. porous implant entity preserved into output format file and transfer in delamination software, adding bottom supporting;
Wherein, output format file stl, delamination software is ontofab;
S7. open fiber selectivity laser fusion equipment metal material 3D printer, porous implant entity is printed;
Specific as follows: to open SLM125HL fiber selectivity laser fusion equipment metal material 3D printer, print porous implant, wherein print parameters is set to: pure titanium density is 4.55g/cm3, laser spot diameter d=83 μm, sweep span h=100-200 μm, power P=70-100W, scan velocity V=100-500mm/s, paving powder thickness t=30-70 μm;
S8. clear up substrate, take out with the porous implant that 3D prints by shovel file;
S9. blasting treatment is carried out to porous implant, make its any surface finish;
S10. porous implant is encapsulated.
The above embodiment only have expressed several embodiment of the present invention, and it describes comparatively concrete and detailed, but therefore can not be interpreted as the restriction to the scope of the claims of the present invention.It should be pointed out that for the person of ordinary skill of the art, without departing from the inventive concept of the premise, can also make some distortion and improvement, these all belong to protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.

Claims (5)

1. a preparation method for the porous implant of being filled by O-intersectinglines unit, is characterized in that, comprises the following steps:
S1. Three-dimensional Design Software is utilized to draw the threedimensional model of O-intersectinglines unit on computers, the threedimensional model face of cylinder is orthogonal between two in space, linearly stacking, by given its aperture of concrete size Control, wall thickness and porosity, generation unit structure cell entity;
S2. array processing is copied to unit structure cell entity, obtain space porous network entity;
S3. the femur three-dimensional surface model that reverse-engineering obtains is directed through, to scaling of model to the ratio of actual needs;
S4. cutting is carried out to porous network entity and femur three-dimension curved surface and Boolean calculation operates, obtain porous bodies part;
S5. draw femur pommel and screw pilot hole position by three-dimensional modeling, and merge porous bodies part and make it to become single output porous implant entity;
S6. porous implant entity preserved into output format file and transfer in delamination software, adding bottom supporting;
S7. open fiber selectivity laser fusion equipment metal material 3D printer, porous implant entity is printed;
S8. clear up substrate, take out with the porous implant that 3D prints by shovel file;
S9. blasting treatment is carried out to porous implant, make its any surface finish;
S10. porous implant is encapsulated.
2. the preparation method of porous implant according to claim 1, is characterized in that, in step S1, described Three-dimensional Design Software is solidworks or pro-eUG.
3. the preparation method of porous implant according to claim 1, is characterized in that, in step S6, described output format file is stl, and described delamination software is ontofab.
4. the preparation method of porous implant according to claim 1, is characterized in that, in step S7, described fiber selectivity laser fusion equipment metal material 3D printer model is SLM125HL.
5. the preparation method of porous implant according to claim 1, it is characterized in that, in step S7, described print parameters is set as: pure titanium density is 4.55g/cm3, laser spot diameter d=80-85 μm, sweep span h=100-200 μm, power P=70-100W, scan velocity V=100-500mm/s, paving powder thickness t=40-70 μm.
CN201510940064.4A 2015-12-15 2015-12-15 Preparation method of porous implant filled with O-intersecting lines units CN105559947A (en)

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Cited By (5)

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CN106109064A (en) * 2016-06-15 2016-11-16 东北大学 A kind of spinal fusion device
WO2018019215A1 (en) * 2016-07-29 2018-02-01 北京形梦信息技术有限公司 Bone repair stent and preparation method therefor
CN107790719A (en) * 2017-11-13 2018-03-13 成都优材科技有限公司 Based on selective laser molten metal fine cellular structure forming method
CN109622958A (en) * 2018-12-20 2019-04-16 华中科技大学 A method of titanium alloy implant is prepared using minimal surface porous structure
CN110384573A (en) * 2018-04-18 2019-10-29 智塑健康科技有限公司 Lightweight femoral stem for hip implant

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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106109064A (en) * 2016-06-15 2016-11-16 东北大学 A kind of spinal fusion device
WO2018019215A1 (en) * 2016-07-29 2018-02-01 北京形梦信息技术有限公司 Bone repair stent and preparation method therefor
CN107661160A (en) * 2016-07-29 2018-02-06 北京形梦信息技术有限公司 A kind of bone repairing support and preparation method thereof
CN107790719A (en) * 2017-11-13 2018-03-13 成都优材科技有限公司 Based on selective laser molten metal fine cellular structure forming method
CN110384573A (en) * 2018-04-18 2019-10-29 智塑健康科技有限公司 Lightweight femoral stem for hip implant
CN110384573B (en) * 2018-04-18 2020-09-22 智塑健康科技有限公司 Lightweight femoral stem for hip implants
CN109622958A (en) * 2018-12-20 2019-04-16 华中科技大学 A method of titanium alloy implant is prepared using minimal surface porous structure
CN109622958B (en) * 2018-12-20 2020-06-02 华中科技大学 Method for preparing titanium alloy implant by adopting minimum curved surface porous structure

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Application publication date: 20160511