CN105535854A - Drug for treating polyneuritis and preparation method of drug - Google Patents
Drug for treating polyneuritis and preparation method of drug Download PDFInfo
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- CN105535854A CN105535854A CN201610042311.3A CN201610042311A CN105535854A CN 105535854 A CN105535854 A CN 105535854A CN 201610042311 A CN201610042311 A CN 201610042311A CN 105535854 A CN105535854 A CN 105535854A
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- 239000003814 drug Substances 0.000 title claims abstract description 33
- 206010029240 Neuritis Diseases 0.000 title claims abstract description 24
- 206010036105 Polyneuropathy Diseases 0.000 title claims abstract description 24
- 208000019629 polyneuritis Diseases 0.000 title claims abstract description 24
- 238000002360 preparation method Methods 0.000 title claims description 6
- 229940079593 drug Drugs 0.000 title abstract description 7
- 239000000843 powder Substances 0.000 claims abstract description 10
- 210000000582 semen Anatomy 0.000 claims abstract description 8
- 239000002775 capsule Substances 0.000 claims abstract description 6
- 239000007788 liquid Substances 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 241000628997 Flos Species 0.000 claims description 7
- 239000012567 medical material Substances 0.000 claims description 7
- 210000002826 placenta Anatomy 0.000 claims description 7
- 239000002994 raw material Substances 0.000 claims description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- 239000000706 filtrate Substances 0.000 claims description 6
- 239000008187 granular material Substances 0.000 claims description 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 3
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 claims description 3
- 238000009835 boiling Methods 0.000 claims description 3
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- 229910002027 silica gel Inorganic materials 0.000 claims description 3
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- 230000000694 effects Effects 0.000 abstract description 5
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- A61K35/50—Placenta; Placental stem cells; Amniotic fluid; Amnion; Amniotic stem cells
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Abstract
The invention provides a drug for treating polyneuritis. The drug is prepared from the following traditional Chinese medicines in parts by weight: 12-17 parts of geranium, 4-7 parts of cimicifugae foetidae, 8-12 parts of achyranthes bidentata, 7-12 parts of ramulus mori, 12-18 parts of radix curcuma, 12-17 parts of semen cuscutae, 8-12 parts of radix curcumae, 12-16 parts of rhizoma typhonii, 9-13 parts of pericarpium citri reticulatae, 8-15 parts of gentiana macrophylla pall, 6-10 parts of placental powder, 15-20 parts of citrus chirocarpus, 13-17 parts of rhizoma alismatis, 10-14 parts of piper wallichii, 12-18 parts of pinellia ternata, 12-17 parts of caulis lonicerae, 7-11 parts of fructus chaenomelis lagenariae, 7-12 parts of cyperus rotundus, 8-14 parts of periostracum cicada and 11-18 parts of safflower. The drug in form of a traditional Chinese medicine capsule has the effects of tonifying Qi, lifting Yang, enriching and activating blood, relieving exterior syndrome, dispelling cold, removing blood stasis and promoting menstrual flow, is used for treating the polyneuritis caused by various reasons and obtains a better curative effect, thereby having a clinical promotion value.
Description
Technical field
The invention belongs to medical field, specifically, relate to a kind of medicine for the treatment of polyneuritis and preparation method thereof.
Background technology
Polyneuritis is due to numerous constitutional causes, causes the multifocal neurological of far-end of limb to be main axonal degeneration and segmental myelinoclasis, and main manifestations is the clinical syndrome of the symmetric sensation of far-end of limb, motion and autonomic nerve dysfunction.Primary disease due to the cause of disease different, the course of disease can have acute, subacute, chronic, recurrent is not.This disease can occur in any age.The symptom of major part patient develops within several weeks to several months.
The muscular strength that polyneuritis starts from lower limb usually goes down, and to trunk, upper limb, face development.Meanwhile, the paraesthesias such as distal limbs symmetry is numb, spontaneity is ached often are had.Most of patients reached summit in onset 3-15 days, and extremity present flaccid paralysis and the distal muscle atrophy of varying degree.Severe patient can have hoarseness, dysarthria, dysphagia, even dyspnea.Play stable disease in 10-25 days after being ill, and start to recover, patient often shows motion, sensation and neuro vegetative dysfunction.Extremity tip is sent out cool, rubescent, cyanosis, hypohidrosis or hyperhidrosis, and thinning of skin is tender or coarse, refers to that (toe) first is thickening and becomes fragile, tarnish, or the horizontal trace of adularescent; Distal limbs symmetry is felt to go down or disappear, or hyperesthesia; Extremity muscular tension declines, and quadriceps reflex weakens or disappears, amyotrophy.
The Therapeutic Method of primary disease and prognosis are due to the cause of disease, the course of disease, the treatment whether difference of the cooperate degree of correct and patient and different in time, at drug treatment, Chinese prescription now commercially for polyneuritis is actually rare, is rule for the treatment of treatment polyneuritis mainly with blood-activating and qi-promoting, rich in nutrition, nourishing the liver and kidney, QI invigorating tonify deficiency.When its ubiquity is taken, the property of medicine is comparatively slow, and the course for the treatment of is longer, the shortcoming that cure rate is not high; Medicine needs of patients long-term taking, therapeutic effect is undesirable.
Summary of the invention
The present invention proposes a kind of medicine for the treatment of polyneuritis, this medicament can effectively be treated polyneuritis, and the clinical condition improving patient resembles, and effectively prevents that sb.'s illness took a turn for the worse, and its concrete technical scheme is as follows:
Treat a medicine for polyneuritis, it is made by the raw material of Chinese medicine of following weight:
Herba Erodii (Herba Geranii): 12 ~ 17 parts; Rhizoma Cimicifugae: 4 ~ 7 parts; Radix Achyranthis Bidentatae: 8 ~ 12 parts; Ramulus Mori: 7 ~ 12 parts; Rhizoma Curcumae Longae: 12 ~ 18 parts;
Semen Cuscutae: 12 ~ 17 parts; Radix Curcumae: 8 ~ 12 parts; Rhizoma Typhonii: 12 ~ 16 parts; Pericarpium Citri Reticulatae: 9 ~ 13 parts; Radix Gentianae Marcrophyllae: 8 ~ 15 parts;
Placenta Hominis powder: 6 ~ 10 parts; Fructus Citri Sarcodactylis: 15 ~ 20 parts; Rhizoma Alismatis: 13 ~ 17 parts; Caulis et Folium piperis: 10 ~ 14 parts; The Rhizoma Pinelliae: 12 ~ 18 parts;
Caulis Lonicerae: 12 ~ 17 parts; Fructus Chaenomelis: 7 ~ 11 parts; Gun additioner: 7 ~ 12 parts; Periostracum Cicadae: 8 ~ 14 parts; Flos Carthami: 11 ~ 18 parts.
Preferably, it is made by the raw material of Chinese medicine of following weight portion:
Herba Erodii (Herba Geranii): 15 parts; Rhizoma Cimicifugae: 5 parts; Radix Achyranthis Bidentatae: 10 parts; Ramulus Mori: 10 parts; Rhizoma Curcumae Longae: 15 parts;
Semen Cuscutae: 15 parts; Radix Curcumae: 10 parts; Rhizoma Typhonii: 14 parts; Pericarpium Citri Reticulatae: 11 parts; Radix Gentianae Marcrophyllae: 12 parts;
Placenta Hominis powder: 8 parts; Fructus Citri Sarcodactylis: 18 parts; Rhizoma Alismatis: 15 parts; Caulis et Folium piperis: 12 parts; The Rhizoma Pinelliae: 15 parts;
Caulis Lonicerae: 15 parts; Fructus Chaenomelis: 9 parts; Gun additioner: 9 parts; Periostracum Cicadae: 11 parts; Flos Carthami: 15 parts.
Treat a preparation method for the medicine of polyneuritis, comprise following processing step:
Get above-mentioned each medical material by weight ratio, first time decocts the 8-10 water boiling and extraction doubly adding medical material gross weight, decocts 1.5-2.5 hour, leaches medicinal liquid stand-by: second time adds the water of 6-8 times amount, decoct 1-1.2h, leach medicinal liquid stand-by; Add the water of 6-8 times amount for the third time, decoct 0.8-1.2h, leach medicinal liquid stand-by; Merge three decocting liquids, filter, collect filtrate; The filtrate relative density be concentrated into 60 DEG C time is 1-1.1; Centrifugal under the rotating speed of 3000r/min; At 60 DEG C of-80 DEG C of spraying dry, obtain dry extract;
Above-mentioned dry extract is pulverized, adds appropriate micropowder silica gel, α-galactose mixing, take ethanol as wetting agent, granulate, dry, granulate, encapsulated, obtained capsule.
The present invention compared with prior art, has following beneficial effect:
Selected by Chinese medicine composition of the present invention, medical material compatibility is suitable, meet Chinese medicine and pharmacy and modern medicine theory, through experimental verification, Chinese medicine composition capsule of the present invention have tonifying Qi and lifting yang, enrich blood invigorate blood circulation, effect of the cold expelling that induces sweat, eliminating blood stasis and inducing menstruation, be used for the treatment of the polyneuritis that a variety of causes causes, obtain good curative effect, and quick result, non-relapse after healing, safe without toxic side effect, cost is lower, can reach the object for the treatment of both the principal and secondary aspects of a disease, have clinical generalization value.
Detailed description of the invention
Below in conjunction with embodiment, a kind of medicine for the treatment of polyneuritis of the present invention and preparation method thereof is described in further detail.
Embodiment 1
Make up a prescription by the raw material of following effective ingredient and composition weight:
Herba Erodii (Herba Geranii): 12 grams; Rhizoma Cimicifugae: 4 grams; Radix Achyranthis Bidentatae: 8 grams; Ramulus Mori: 7 grams; Rhizoma Curcumae Longae: 12 grams;
Semen Cuscutae: 12 grams; Radix Curcumae: 8 grams; Rhizoma Typhonii: 12 grams; Pericarpium Citri Reticulatae: 9 grams; Radix Gentianae Marcrophyllae: 8 grams;
Placenta Hominis powder: 6 grams; Fructus Citri Sarcodactylis: 15 grams; Rhizoma Alismatis: 13 grams; Caulis et Folium piperis: 10 grams; The Rhizoma Pinelliae: 12 grams;
Caulis Lonicerae: 12 grams; Fructus Chaenomelis: 7 grams; Gun additioner: 7 grams; Periostracum Cicadae: 8 grams; Flos Carthami: 11 grams.
Embodiment 2
The raw material composition of effective ingredient of the present invention and weight are:
Herba Erodii (Herba Geranii): 17 grams; Rhizoma Cimicifugae: 7 grams; Radix Achyranthis Bidentatae: 12 grams; Ramulus Mori: 12 grams; Rhizoma Curcumae Longae: 18 grams;
Semen Cuscutae: 17 grams; Radix Curcumae: 12 grams; Rhizoma Typhonii: 16 grams; Pericarpium Citri Reticulatae: 13 grams; Radix Gentianae Marcrophyllae: 15 grams;
Placenta Hominis powder: 10 grams; Fructus Citri Sarcodactylis: 20 grams; Rhizoma Alismatis: 17 grams; Caulis et Folium piperis: 14 grams; The Rhizoma Pinelliae: 18 grams;
Caulis Lonicerae: 17 grams; Fructus Chaenomelis: 11 grams; Gun additioner: 12 grams; Periostracum Cicadae: 14 grams; Flos Carthami: 18 grams.
Embodiment 3
The raw material composition of effective ingredient of the present invention and weight are:
Herba Erodii (Herba Geranii): 15 grams; Rhizoma Cimicifugae: 5 grams; Radix Achyranthis Bidentatae: 10 grams; Ramulus Mori: 10 grams; Rhizoma Curcumae Longae: 15 grams;
Semen Cuscutae: 15 grams; Radix Curcumae: 10 grams; Rhizoma Typhonii: 14 grams; Pericarpium Citri Reticulatae: 11 grams; Radix Gentianae Marcrophyllae: 12 grams;
Placenta Hominis powder: 8 grams; Fructus Citri Sarcodactylis: 18 grams; Rhizoma Alismatis: 15 grams; Caulis et Folium piperis: 12 grams; The Rhizoma Pinelliae: 15 grams;
Caulis Lonicerae: 15 grams; Fructus Chaenomelis: 9 grams; Gun additioner: 9 grams; Periostracum Cicadae: 11 grams; Flos Carthami: 15 grams.
Embodiment 4
Each medical material by weight ratio that Example 1-3 is arbitrary, first time decocts the 8-10 water boiling and extraction doubly adding medical material gross weight, decocts 1.5-2.5 hour, leaches medicinal liquid stand-by: second time adds the water of 6-8 times amount, decoct 1-1.2h, leach medicinal liquid stand-by; Add the water of 6-8 times amount for the third time, decoct 0.8-1.2h, leach medicinal liquid stand-by; Merge three decocting liquids, filter, collect filtrate; The filtrate relative density be concentrated into 60 DEG C time is 1-1.1; Centrifugal under the rotating speed of 3000r/min; At 60 DEG C of-80 DEG C of spraying dry, obtain dry extract;
Obtained dry extract be dry, pulverize, make powder; Or dry extract obtained for step (1) is pulverized, adds appropriate micropowder silica gel, α-galactose mixing, take ethanol as wetting agent, granulate, dry, granulate, encapsulated, obtained capsule;
Clinical data:
1, case selection:
Face middle Stochastic choice polyneuritis patient 80 example, wherein male patient 52 example, age 40-65 year, female patient 28 example, age 45-60 year.
2, medicament selection:
Use capsule obtained in embodiment 5 to treat, every day 3 times, each 3 powders (every containing 1.0g formula effective ingredient), treating January is a course for the treatment of.
3, efficacy determination:
(1) cure: polyneuritis symptom all disappears.
(2) effective: polyneuritis symptom alleviates.
(3) effective: polyneuritis symptom makes moderate progress.
(4) invalid: polyneuritis symptom is without being clearly better or increasing the weight of.
4, therapeutic effect
The present invention treats 80 examples, and result clinical cure 36 example, accounts for 45%, and effective 28 examples, account for 35%, and effective 14 examples, account for 17.5%, and invalid 2 examples, account for 2.5%, total effective rate 97.5%.
5, model case
Case 1, Sun Nvshi, 48 years old, patient moving obstacle, myasthenia of limbs, acral feels pain, numbness.After taking a course for the treatment of of this Chinese medicine, acrodynia and feeling of numbness alleviate to some extent, recover motor capacity, then after taking a course for the treatment of, symptom all disappear.
Case 2, Mr. Kong, 57 years old, acrodynia was burnt, feeling of numbness, and tendon reflex weakens.Take Western medicine and fail radical cure always, after the course for the treatment of of oral medicine of the present invention, pain alleviates to some extent, and feeling of numbness gradually moves back, then after taking two courses for the treatment of, symptom all disappears.
Case 3, Mrs Xu, 60 years old, acral pain, moving difficulty, acra skin was sent out cool, pachylosis, and after taking a course for the treatment of of this Chinese medicine, acrodynia sense alleviates to some extent, recover motor capacity, then after taking two courses for the treatment of, symptom all disappears.
Above result display, medicine of the present invention effectively can treat polyneuritis, treatment short treating period, Be very effective.
Claims (3)
1. treat a medicine for polyneuritis, it is characterized in that: it is made by the raw material of Chinese medicine of following weight:
Herba Erodii (Herba Geranii): 12 ~ 17 parts; Rhizoma Cimicifugae: 4 ~ 7 parts; Radix Achyranthis Bidentatae: 8 ~ 12 parts; Ramulus Mori: 7 ~ 12 parts; Rhizoma Curcumae Longae: 12 ~ 18 parts;
Semen Cuscutae: 12 ~ 17 parts; Radix Curcumae: 8 ~ 12 parts; Rhizoma Typhonii: 12 ~ 16 parts; Pericarpium Citri Reticulatae: 9 ~ 13 parts; Radix Gentianae Marcrophyllae: 8 ~ 15 parts;
Placenta Hominis powder: 6 ~ 10 parts; Fructus Citri Sarcodactylis: 15 ~ 20 parts; Rhizoma Alismatis: 13 ~ 17 parts; Caulis et Folium piperis: 10 ~ 14 parts; The Rhizoma Pinelliae: 12 ~ 18 parts;
Caulis Lonicerae: 12 ~ 17 parts; Fructus Chaenomelis: 7 ~ 11 parts; Gun additioner: 7 ~ 12 parts; Periostracum Cicadae: 8 ~ 14 parts; Flos Carthami: 11 ~ 18 parts.
2. a kind of medicine for the treatment of polyneuritis according to claim 1, is characterized in that: it is made by the raw material of Chinese medicine of following weight portion:
Herba Erodii (Herba Geranii): 15 parts; Rhizoma Cimicifugae: 5 parts; Radix Achyranthis Bidentatae: 10 parts; Ramulus Mori: 10 parts; Rhizoma Curcumae Longae: 15 parts;
Semen Cuscutae: 15 parts; Radix Curcumae: 10 parts; Rhizoma Typhonii: 14 parts; Pericarpium Citri Reticulatae: 11 parts; Radix Gentianae Marcrophyllae: 12 parts;
Placenta Hominis powder: 8 parts; Fructus Citri Sarcodactylis: 18 parts; Rhizoma Alismatis: 15 parts; Caulis et Folium piperis: 12 parts; The Rhizoma Pinelliae: 15 parts;
Caulis Lonicerae: 15 parts; Fructus Chaenomelis: 9 parts; Gun additioner: 9 parts; Periostracum Cicadae: 11 parts; Flos Carthami: 15 parts.
3. treat a preparation method for the medicine of polyneuritis as claimed in claim 1 or 2, it is characterized in that: comprise following processing step:
Step 1): get the arbitrary described each medical material by weight ratio of claim 1 or 2, first time decocts the 8-10 water boiling and extraction doubly adding medical material gross weight, decocts 1.5-2.5 hour, leaches medicinal liquid stand-by: second time adds the water of 6-8 times amount, decoct 1-1.2h, leach medicinal liquid stand-by; Add the water of 6-8 times amount for the third time, decoct 0.8-1.2h, leach medicinal liquid stand-by; Merge three decocting liquids, filter, collect filtrate; The filtrate relative density be concentrated into 60 DEG C time is 1-1.1; Centrifugal under the rotating speed of 3000r/min; At 60 DEG C of-80 DEG C of spraying dry, obtain dry extract;
Dry extract obtained for step 1) is pulverized, adds appropriate micropowder silica gel, α-galactose mixing, take ethanol as wetting agent, granulate, dry, granulate, encapsulated, obtained capsule.
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| CN101703716A (en) * | 2009-10-22 | 2010-05-12 | 蒲灵珍 | Chinese medicinal preparation for treating polyneuritis |
| CN102000286A (en) * | 2010-11-11 | 2011-04-06 | 吴金霞 | Traditional Chinese medicine preparation for treating polyneuritis |
| CN105213974A (en) * | 2015-10-19 | 2016-01-06 | 青岛市中心医院 | One treats lymphadenomatous Chinese medicine composition and application thereof |
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| CN101703716A (en) * | 2009-10-22 | 2010-05-12 | 蒲灵珍 | Chinese medicinal preparation for treating polyneuritis |
| CN102000286A (en) * | 2010-11-11 | 2011-04-06 | 吴金霞 | Traditional Chinese medicine preparation for treating polyneuritis |
| CN105213974A (en) * | 2015-10-19 | 2016-01-06 | 青岛市中心医院 | One treats lymphadenomatous Chinese medicine composition and application thereof |
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