CN105513084A - 一种多层螺旋ct肺动脉成像中固定对比剂剂量的试验方法 - Google Patents

一种多层螺旋ct肺动脉成像中固定对比剂剂量的试验方法 Download PDF

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CN105513084A
CN105513084A CN201610019979.6A CN201610019979A CN105513084A CN 105513084 A CN105513084 A CN 105513084A CN 201610019979 A CN201610019979 A CN 201610019979A CN 105513084 A CN105513084 A CN 105513084A
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顾庆春
范晔辉
薛春华
吕传国
杨波
陈炜
李健
蒋华东
陈蔚
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QIDONG CITY PEOPLES' HOSPITAL
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Abstract

本发明涉及一种多层螺旋CT肺动脉成像中固定对比剂剂量的试验方法,所述试验方法的具体步骤如下:(1)选取患者;(2)扫描图像;(3)图像后处理;(4)图像质量评价;试验方法中对比剂用量为35ml或0.7ml/kg。本发明的优点在于:通过该试验方法,确定了肺动脉CT成像中对比剂用量使用固定值是可行的;这样不仅减少了对比剂用量,降低了对比剂肾病发生的风险,而且降低了上腔静脉中对比剂的残留,提高了图像质量。

Description

一种多层螺旋CT肺动脉成像中固定对比剂剂量的试验方法
技术领域
本发明属于医学影像技术领域,特别涉及一种多层螺旋CT肺动脉成像中固定对比剂剂量的试验方法。
背景技术
肺动脉栓塞是一个高发病、高致死率、高致残率、低检出的一个常见的疾病,目前CT肺动脉成像已成为诊断肺动脉栓塞的首选方法,然而CT肺动脉检查中对比剂用量尚无统一标准。
文献报告(张龙江,卢光明.CT血管成像静脉注射碘对比剂的原则和策略[J].中华放射学杂志,2011,45(6):597-600.)经典的CT血管成像中,对比剂用量一直按公斤体重来计算。文献报告(RamadanSU,KosarP,SonmczI,etal.Optimisationofcontrastmediumvolumeandinjection-relatedfactorsinCTpulmonaryangiography:64-sliceCTstudy[J].EurRadial,2010,20:2100-2107.)Ramadan等就60,55和50mL的对比剂用量进行了比较研究,认为50-55mL用量可使肺动脉强化良好,血管强化程度大于250HU,血管显示清晰。(HunsakerAR,OlivaIB,CaiT,etal.ContrastopacificationusingareducedvolnmcofiodinatedcontrastmaterialandlowpeakkilovoltagcinpulmonaryCTangiography:objectiveandsubjectiveevaluation[J].AJR,2010,195:W118-124.)Hunsaker等采用75mL和125mL分组研究,认为75mL对比剂可以使血管强化良好,两组叶、段级肺动脉强化程度差异无统计学意义。
在我们熟知的多层螺旋CT肝门静脉造影中,对比剂经过一个完整的肺循环与体循环后回流进入门静脉,因此,体重大小对于CT门静脉造影中对比剂的用量多少起着决定性作用,体重大的患者必须使用大剂量的对比剂,才能获得满意的门静脉图像。而肺动脉是CT血管成像中全身第一个显像的动脉。对比剂经肘静脉、锁骨下静脉、上腔静脉、右心房、右心室后即刻进入肺动脉,其显影时尚未经过一个完整的肺循环。因此,体重的大小对于对比剂用量的影响微乎其微,几乎可以忽略不计,理论上对比剂用量与体重的相关性不大。
发明内容
本发明要解决的技术问题是提供一种多层螺旋CT肺动脉成像中固定对比剂剂量的试验方法。
为解决上述技术问题,本发明的技术方案为:一种多层螺旋CT肺动脉成像中固定对比剂剂量的试验方法,其创新点在于:所述试验方法的具体步骤如下:
(1)选取患者:选取进行肺动脉检查患者,年龄39~80岁,中位年龄51岁,体重均大于等于50kg;
(2)扫描图像:采用西门子SOMATOMSensation64螺旋CT进行扫描,扫描参数为:管电压120kV,管电流110mAs,准直器宽度64x0.6mm,螺距1.0,重建层厚0.6mm,重建增量0.4mm,检查前禁食4~6h,对比剂为370mgI/m1的碘帕醇注射液,采用双筒高压注射器经肘前静脉注射,注射速率5.0ml/s,注射完毕后以相同速率注射50ml生理盐水,扫描范围肺尖至肺底,采用从头侧向足侧扫描,扫描周期为3.87~5.24s,用Bolus-tracking团注追踪与自动触发技术,靶血管选择肺动脉主干,触发阈值设置为触发点平扫值加5Hu,触发后延迟4s开始扫描;
(3)图像后处理:将数据传至工作站进行后处理,包括MIP、MPR、VRT,并测量各组图像的肺动脉主干、上腔静脉、左心房CT值;
(4)图像质量评价:以轴位图像及重建冠状位、VR图像评价各组肺血管及上腔静脉的显示程度并进行评分。
进一步地,所述步骤(2)中的对比剂用量为35ml或0.7ml/kg。
本发明的优点在于:通过该试验方法,在管电压120kV,管电流110mAs,准直器宽度64x0.6mm,螺距1.0,重建层厚0.6mm,重建增量0.4mm,检查前禁食4~6h,对比剂为370mgI/m1的碘帕醇注射液,采用双筒高压注射器经肘前静脉注射,注射速率5.0ml/s的扫描条件下,确定了肺动脉CT成像中对比剂用量使用固定值是可行的;这样不仅减少了对比剂用量,降低了对比剂肾病发生的风险,而且降低了上腔静脉中对比剂的残留,提高了图像质量。
具体实施方式
下面的实施例可以使本专业的技术人员更全面地理解本发明,但并不因此将本发明限制在所述的实施例范围之中。
实施例1
(1)选取患者:随机选取我院进行肺动脉检查患者30例,其中男12例,女18例,年龄39~80岁,中位年龄51岁,体重均大于等于50kg;
(2)扫描图像:采用西门子SOMATOMSensation64螺旋CT进行扫描,扫描参数为:管电压120kV,管电流110mAs,准直器宽度64x0.6mm,螺距1.0,重建层厚0.6mm,重建增量0.4mm,检查前禁食4~6h,对比剂用370mgI/m1的碘帕醇注射液35ml,采用双筒高压注射器经肘前静脉注射,注射速率5.0ml/s,注射完毕后以相同速率注射50ml生理盐水,扫描范围肺尖至肺底,采用从头侧向足侧扫描,扫描周期为3.87~5.24s,用Bolus-tracking团注追踪与自动触发技术,靶血管选择肺动脉主干,触发阈值设置为触发点平扫值加5Hu,触发后延迟4s开始扫描;
(3)图像后处理:将数据传至工作站进行后处理,包括MIP、MPR、VRT,由同1名医师测量各组图像的肺动脉主干、上腔静脉、左心房CT值;
(4)图像质量评价:以轴位图像及重建冠状位、VR图像评价各组肺血管及上腔静脉的显示程度并进行评分。
实施例2
(1)选取患者:随机选取我院进行肺动脉检查患者30例,其中男13例,女17例,年龄39~80岁,中位年龄51岁,体重51.9~76.1kg不等;
(2)扫描图像:采用西门子SOMATOMSensation64螺旋CT进行扫描,扫描参数为:管电压120kV,管电流110mAs,准直器宽度64x0.6mm,螺距1.0,重建层厚0.6mm,重建增量0.4mm,检查前禁食4~6h,对比剂用370mgI/m1的碘帕醇注射液0.7ml/kg,采用双筒高压注射器经肘前静脉注射,注射速率5.0ml/s,注射完毕后以相同速率注射50ml生理盐水,扫描范围肺尖至肺底,采用从头侧向足侧扫描,扫描周期为3.87~5.24s,用Bolus-tracking团注追踪与自动触发技术,靶血管选择肺动脉主干,触发阈值设置为触发点平扫值加5Hu,触发后延迟4s开始扫描;
(3)图像后处理:将数据传至工作站进行后处理,包括MIP、MPR、VRT,由同1名医师测量各组图像的肺动脉主干、上腔静脉、左心房CT值;
(4)图像质量评价:以轴位图像及重建冠状位、VR图像评价各组肺血管及上腔静脉的显示程度并进行评分。
评分标准
好(4分):亚段级肺动脉显示清晰,对比剂浓度高,肺静脉几乎无显影,上腔静脉对比剂浓度低,CT平均值小于200HU;
较好(3分):叶段级肺动脉显示清楚,对比剂浓度较高,肺静脉轻度强化,上腔静脉CT平均值大于200HU,但小于肺动脉主干CT平均值;
一般(2分):肺动脉干显示清楚,对比剂浓度尚可,肺静脉强化,但密度低于肺动脉,或上腔静脉CT平均值大于肺动脉主干CT平均值,尚没有出现放射状伪影;
差(1分):肺动脉干显示不清,对比剂浓度低,或肺静脉密度高于肺动脉,或上腔静脉内残留对比剂浓度高,出现放射状伪影,CT值大于1000HU。
由2名中级以上职称的放射学医师采用盲法对各组图像进行评分,二者意见一致时确认结果,二者意见不一致时由一位主任医师裁决。
统计学分析
使用SPSS13.0软件,两组患者采用t检验,P<0.05为差异具有统计学意义。
结果:
实施例1与实施例2肺动脉主干、上腔静脉、左心房CT平均值的比较:
两实施例肺动脉主干、左心房、CT平均值无显著性差异(P均>0.05,表1);两实施例上腔静脉CT平均值有统计学意义(P<0.01)。
表1实施例1与实施例2肺动脉、肺静脉、主动脉CT值的比较(HU)
组别 肺动脉主干 上腔静脉 左心房
A组 453.32±23.21 183.1±16.36 154.5±16.34
B组 462.3±25.35 556.4±120.28 157.5±17.32
P值 >0.05 <0.01 >0.05
图像质量评价
2名医师采用双盲法对两实施例的病例的图像评分见表2。实施例1、实施例2图像平均得分分别为3.8、2.7分。
表2两实施例图像质量评分表
组别 好(4分) 较好(3分) 一般(2分) 差(1分)
实施例1 24 6 0 0
实施例2 12 8 6 4
结论:肺动脉CT成像中对比剂用量使用固定值是可行的,不仅减少了对比剂用量,降低了对比剂肾病发生的风险,而且降低了上腔静脉中对比剂的残留,提高了图像质量。
以上显示和描述了本发明的基本原理和主要特征以及本发明的优点。本行业的技术人员应该了解,本发明不受上述实施例的限制,上述实施例和说明书中描述的只是说明本发明的原理,在不脱离本发明精神和范围的前提下,本发明还会有各种变化和改进,这些变化和改进都落入要求保护的本发明范围内。本发明要求保护范围由所附的权利要求书及其等效物界定。

Claims (2)

1.一种多层螺旋CT肺动脉成像中固定对比剂剂量的试验方法,其特征在于:所述试验方法的具体步骤如下:
(1)选取患者:选取进行肺动脉检查患者,年龄39~80岁,中位年龄51岁,体重均大于等于50kg;
(2)扫描图像:采用西门子SOMATOMSensation64螺旋CT进行扫描,扫描参数为:管电压120kV,管电流110mAs,准直器宽度64x0.6mm,螺距1.0,重建层厚0.6mm,重建增量0.4mm,检查前禁食4~6h,对比剂为370mgI/m1的碘帕醇注射液,采用双筒高压注射器经肘前静脉注射,注射速率5.0ml/s,注射完毕后以相同速率注射50ml生理盐水,扫描范围肺尖至肺底,采用从头侧向足侧扫描,扫描周期为3.87~5.24s,用Bolus-tracking团注追踪与自动触发技术,靶血管选择肺动脉主干,触发阈值设置为触发点平扫值加5Hu,触发后延迟4s开始扫描;
(3)图像后处理:将数据传至工作站进行后处理,包括MIP、MPR、VRT,并测量各组图像的肺动脉主干、上腔静脉、左心房CT值;
(4)图像质量评价:以轴位图像及重建冠状位、VR图像评价各组肺血管及上腔静脉的显示程度并进行评分。
2.根据权利要求1所述的多层螺旋CT肺动脉成像中固定对比剂剂量的试验方法,其特征在于:所述步骤(2)中的对比剂用量为35ml或0.7ml/kg。
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