CN105498671A - Intelligent preparation device for medical intermediate - Google Patents
Intelligent preparation device for medical intermediate Download PDFInfo
- Publication number
- CN105498671A CN105498671A CN201511033674.2A CN201511033674A CN105498671A CN 105498671 A CN105498671 A CN 105498671A CN 201511033674 A CN201511033674 A CN 201511033674A CN 105498671 A CN105498671 A CN 105498671A
- Authority
- CN
- China
- Prior art keywords
- cylindrical shell
- heating plate
- barrel
- described cylindrical
- interlayer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 238000010438 heat treatment Methods 0.000 claims abstract description 35
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims abstract description 22
- 239000013078 crystal Substances 0.000 claims abstract description 18
- 239000011229 interlayer Substances 0.000 claims abstract description 18
- 239000010410 layer Substances 0.000 claims abstract description 15
- 239000002826 coolant Substances 0.000 claims abstract description 13
- 239000007788 liquid Substances 0.000 claims abstract description 11
- 229910052697 platinum Inorganic materials 0.000 claims abstract description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 11
- 238000009413 insulation Methods 0.000 claims abstract description 9
- 238000003756 stirring Methods 0.000 claims abstract description 8
- 238000001816 cooling Methods 0.000 claims abstract description 7
- 238000012544 monitoring process Methods 0.000 claims abstract description 7
- 239000003814 drug Substances 0.000 claims description 17
- 239000011490 mineral wool Substances 0.000 claims description 3
- 239000003973 paint Substances 0.000 claims description 3
- 238000004321 preservation Methods 0.000 claims description 3
- 238000006243 chemical reaction Methods 0.000 abstract description 2
- 239000000543 intermediate Substances 0.000 description 12
- 238000004519 manufacturing process Methods 0.000 description 5
- 239000000126 substance Substances 0.000 description 4
- 238000000034 method Methods 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 230000009471 action Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000003317 industrial substance Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000001953 recrystallisation Methods 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 230000008901 benefit Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0006—Controlling or regulating processes
- B01J19/0013—Controlling the temperature of the process
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0053—Details of the reactor
- B01J19/0066—Stirrers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/02—Apparatus characterised by being constructed of material selected for its chemically-resistant properties
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/18—Stationary reactors having moving elements inside
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00049—Controlling or regulating processes
- B01J2219/00051—Controlling the temperature
- B01J2219/00054—Controlling or regulating the heat exchange system
- B01J2219/00056—Controlling or regulating the heat exchange system involving measured parameters
- B01J2219/00058—Temperature measurement
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00049—Controlling or regulating processes
- B01J2219/00051—Controlling the temperature
- B01J2219/00054—Controlling or regulating the heat exchange system
- B01J2219/00056—Controlling or regulating the heat exchange system involving measured parameters
- B01J2219/00065—Pressure measurement
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/0068—Means for controlling the apparatus of the process
- B01J2219/00686—Automatic
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention relates to an intelligent preparation device for a medical intermediate, which comprises a barrel with supporting legs, wherein a stirring shaft which is driven by a variable frequency motor and is provided with stirring blades is arranged in the barrel, a crystal outlet and a crystal water outlet are arranged at the bottom and on the side wall of the barrel, a feed liquid inlet and a crystal seed inlet are arranged at the top end of the barrel, the barrel is a barrel wall and provided with an interlayer, a cooling coil which is spirally wound is arranged in the interlayer, a coolant outlet and a coolant inlet of the cooling coil are respectively arranged on the side wall of the barrel, a heat insulation layer is arranged in the interlayer, a first heating plate is arranged at the bottom in the barrel, a second heating plate is arranged at the upper end of the barrel, a platinum resistance temperature sensor is embedded in the outer wall of. The invention can realize the reaction processing through the automatic control set by the remote monitoring terminal.
Description
Technical field
The invention belongs to medicine intermediate production technical field, be specifically related to a kind of medicine intermediate intelligence preparation facilities.
Background technology
So-called medicine intermediate, is actually some for some industrial chemicals in medicine synthesis process or chemical products.This chemical products, do not need the production licence of medicine, can produce in common chemical plant, as long as reach the rank of some, namely can be used for the synthesis of medicine.China about needs the raw material supporting with chemical industry and intermediate kind more than 2000 every year, and demand reaches more than 2,500,000 tons.Through the development of more than 30 years, the industrial chemicals needed for China's medicine production and intermediate substantially can be supporting, only have small part to need import.And due to china natural resources abundanter, the prices of raw and semifnished materials are lower, have many intermediates to achieve a large amount of outlet.
In the production process of medicine intermediate, need multiple hybrid reaction repeatedly, extraction, recrystallization and filter operation, on current market, when carrying out above operation, used device structure is simple, and intelligence degree is low, thus makes recrystallization effect not be very desirable, therefore, develop a kind of novel equipment and there is important production practices and realistic meaning.
Summary of the invention
The object of the invention is to solve above-mentioned technical problem and a kind of medicine intermediate intelligence preparation facilities is provided.
For achieving the above object, the present invention adopts following technical scheme:
A kind of medicine intermediate intelligence preparation facilities, comprise the cylindrical shell of band feet, the shaft with stirring vane driven by variable-frequency motor is provided with in described cylindrical shell, the bottom crystalline outlet of described cylindrical shell, sidewall is provided with brilliant water out, the top of described cylindrical shell is provided with feed liquid port and crystal seed entrance, described cylindrical shell is that barrel has interlayer, the cooling coil of helical coil is provided with in described interlayer, the coolant outlet of described cooler pan and entrance are respectively equipped with on the sidewall of described cylindrical shell, heat-insulation layer is provided with in described interlayer, described cylindrical shell inner bottom part is provided with the first heating plate, upper end is provided with the second heating plate, the outer wall of described cylindrical shell is embedded with platinum resistance temperature sensor, the top of described cylindrical shell is provided with air extractor and pressure sensor, described variable-frequency motor, platinum resistance temperature sensor, first heating plate and the second heating plate, air extractor, pressure sensor connects the controller with display screen and manual key, described control wirelessly connects remote supervisory and control(ling) equipment, described crystal outlet, brilliant water out, feed liquid port, crystal seed entrance, coolant outlet and entrance install the motor-operated control valve be connected with described controller.
Described first heating plate and the second heating plate are Electromagnetic Heating plate, and the outside of described Electromagnetic Heating plate scribbles anticorrosive paint layer.
Described heat-insulation layer is rock wool heat-preservation layer.
Described remote supervisory and control(ling) equipment be monitoring host computer and or mobile terminal.
The present invention by being provided with the shaft with stirring vane driven by variable-frequency motor in cylindrical shell, the bottom crystalline outlet of described cylindrical shell, sidewall is provided with brilliant water out, the top of described cylindrical shell is provided with feed liquid port and crystal seed entrance, described cylindrical shell is that barrel has interlayer, the cooling coil of helical coil is provided with in described interlayer, the coolant outlet of described cooler pan and entrance are respectively equipped with on the sidewall of described cylindrical shell, heat-insulation layer is provided with in described interlayer, described cylindrical shell inner bottom part is provided with the first heating plate, upper end is provided with the second heating plate, the outer wall of described cylindrical shell is embedded with platinum resistance temperature sensor, the top of described cylindrical shell is provided with air extractor and pressure sensor, described variable-frequency motor, platinum resistance temperature sensor, first heating plate and the second heating plate, air extractor, pressure sensor connects the controller with display screen and manual key, described control wirelessly connects remote supervisory and control(ling) equipment, described crystal outlet, brilliant water out, feed liquid port, crystal seed entrance, coolant outlet and entrance install the motor-operated control valve be connected with described controller, can realize by the automatic process controlling to carry out reacting of remote monitoring terminal setting, basic eliminating manpower, have great importance.
Accompanying drawing explanation
The schematic diagram of the medicine intermediate intelligence preparation facilities that Fig. 1 provides for the embodiment of the present invention.
Detailed description of the invention
Below, in conjunction with example, substantive distinguishing features of the present invention and advantage are further described, but the present invention is not limited to listed embodiment.
Shown in Figure 1, a kind of medicine intermediate intelligence preparation facilities, comprise the cylindrical shell 1 of band feet 20, the shaft 3 with stirring vane driven by variable-frequency motor 2 is provided with in described cylindrical shell, the bottom crystalline outlet 13 of described cylindrical shell, sidewall is provided with brilliant water out 18, the top of described cylindrical shell is provided with feed liquid port 6 and crystal seed entrance 7, described cylindrical shell is that barrel has interlayer 10, the cooling coil 11 of helical coil is provided with in described interlayer, coolant outlet 8 and the entrance 9 of described cooler pan are respectively equipped with on the sidewall of described cylindrical shell, heat-insulation layer 12 is provided with in described interlayer, described cylindrical shell inner bottom part is provided with the first heating plate 14, upper end is provided with the second heating plate 15, the outer wall of described cylindrical shell is embedded with platinum resistance temperature sensor 16, the top of described cylindrical shell is provided with air extractor 5 and pressure sensor 4, described variable-frequency motor, platinum resistance temperature sensor, first heating plate and the second heating plate, air extractor, pressure sensor connects the controller 17 with display screen and manual key, described control wirelessly connects remote supervisory and control(ling) equipment 19, described crystal outlet, brilliant water out, feed liquid port, crystal seed entrance, coolant outlet and entrance install the motor-operated control valve be connected with described controller.
Wherein, described first heating plate and the second heating plate are Electromagnetic Heating plate, and the outside of described Electromagnetic Heating plate scribbles anticorrosive paint layer.
In specific implementation, described heat-insulation layer is rock wool heat-preservation layer.
It should be noted that, in the present invention, described remote supervisory and control(ling) equipment 19 be monitoring host computer and or mobile terminal.
The present invention can transmit each mechanism action that described controller goes to control to be connected by described remote monitoring terminal setup control parameter, thus realize automatically controlling charging, whether etc. the action of the how many and air extractor of stirring, discharging, heating, cooling agent addition, achieves the automatic control of intelligence.
The present invention by being provided with the shaft with stirring vane driven by variable-frequency motor in cylindrical shell, the bottom crystalline outlet of described cylindrical shell, sidewall is provided with brilliant water out, the top of described cylindrical shell is provided with feed liquid port and crystal seed entrance, described cylindrical shell is that barrel has interlayer, the cooling coil of helical coil is provided with in described interlayer, the coolant outlet of described cooler pan and entrance are respectively equipped with on the sidewall of described cylindrical shell, heat-insulation layer is provided with in described interlayer, described cylindrical shell inner bottom part is provided with the first heating plate, upper end is provided with the second heating plate, the outer wall of described cylindrical shell is embedded with platinum resistance temperature sensor, the top of described cylindrical shell is provided with air extractor and pressure sensor, described variable-frequency motor, platinum resistance temperature sensor, first heating plate and the second heating plate, air extractor, pressure sensor connects the controller with display screen and manual key, described control wirelessly connects remote supervisory and control(ling) equipment, described crystal outlet, brilliant water out, feed liquid port, crystal seed entrance, coolant outlet and entrance install the motor-operated control valve be connected with described controller, can realize by the automatic process controlling to carry out reacting of remote monitoring terminal setting, basic eliminating manpower, have great importance.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the premise without departing from the principles of the invention; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (4)
1. a medicine intermediate intelligence preparation facilities, it is characterized in that, comprise the cylindrical shell of band feet, the shaft with stirring vane driven by variable-frequency motor is provided with in described cylindrical shell, the bottom crystalline outlet of described cylindrical shell, sidewall is provided with brilliant water out, the top of described cylindrical shell is provided with feed liquid port and crystal seed entrance, described cylindrical shell is that barrel has interlayer, the cooling coil of helical coil is provided with in described interlayer, the coolant outlet of described cooler pan and entrance are respectively equipped with on the sidewall of described cylindrical shell, heat-insulation layer is provided with in described interlayer, described cylindrical shell inner bottom part is provided with the first heating plate, upper end is provided with the second heating plate, the outer wall of described cylindrical shell is embedded with platinum resistance temperature sensor, the top of described cylindrical shell is provided with air extractor and pressure sensor, described variable-frequency motor, platinum resistance temperature sensor, first heating plate and the second heating plate, air extractor, pressure sensor connects the controller with display screen and manual key, described control wirelessly connects remote supervisory and control(ling) equipment, described crystal outlet, brilliant water out, feed liquid port, crystal seed entrance, coolant outlet and entrance install the motor-operated control valve be connected with described controller.
2. according to claim 1 medicine intermediate intelligence preparation facilities, it is characterized in that, described first heating plate and the second heating plate are Electromagnetic Heating plate, and the outside of described Electromagnetic Heating plate scribbles anticorrosive paint layer.
3. according to claim 2 medicine intermediate intelligence preparation facilities, it is characterized in that, described heat-insulation layer is rock wool heat-preservation layer.
4. according to claim 3 medicine intermediate intelligence preparation facilities, it is characterized in that, described remote supervisory and control(ling) equipment be monitoring host computer and or mobile terminal.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201511033674.2A CN105498671A (en) | 2015-12-31 | 2015-12-31 | Intelligent preparation device for medical intermediate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201511033674.2A CN105498671A (en) | 2015-12-31 | 2015-12-31 | Intelligent preparation device for medical intermediate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105498671A true CN105498671A (en) | 2016-04-20 |
Family
ID=55707203
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201511033674.2A Pending CN105498671A (en) | 2015-12-31 | 2015-12-31 | Intelligent preparation device for medical intermediate |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105498671A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106000239A (en) * | 2016-06-27 | 2016-10-12 | 天津市鹏翔科技有限公司 | Combined reactor |
| CN111921479A (en) * | 2020-08-18 | 2020-11-13 | 常熟市天工医药化工设备有限公司 | High-efficient reation kettle is used in pharmacy |
| CN112774506A (en) * | 2020-12-28 | 2021-05-11 | 湖北智盛纺织科技有限公司 | Textile slurry stirring device capable of stirring uniformly and using method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN202554995U (en) * | 2012-04-13 | 2012-11-28 | 四川科伦药业股份有限公司 | Crystallizing tank for extracting traditional Chinese medicine |
| CN104722256A (en) * | 2013-12-21 | 2015-06-24 | 天津市华晋溥化工有限公司 | Novel chemical reaction kettle with adjustable temperature |
-
2015
- 2015-12-31 CN CN201511033674.2A patent/CN105498671A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN202554995U (en) * | 2012-04-13 | 2012-11-28 | 四川科伦药业股份有限公司 | Crystallizing tank for extracting traditional Chinese medicine |
| CN104722256A (en) * | 2013-12-21 | 2015-06-24 | 天津市华晋溥化工有限公司 | Novel chemical reaction kettle with adjustable temperature |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106000239A (en) * | 2016-06-27 | 2016-10-12 | 天津市鹏翔科技有限公司 | Combined reactor |
| CN111921479A (en) * | 2020-08-18 | 2020-11-13 | 常熟市天工医药化工设备有限公司 | High-efficient reation kettle is used in pharmacy |
| CN112774506A (en) * | 2020-12-28 | 2021-05-11 | 湖北智盛纺织科技有限公司 | Textile slurry stirring device capable of stirring uniformly and using method thereof |
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| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20160420 |