CN105497733A

CN105497733A - Chinese herb preparation for treating intestinal obstruction and preparation method thereof

Info

Publication number: CN105497733A
Application number: CN201510996279.8A
Authority: CN
Inventors: 于杰
Original assignee: Qingdao Third Peoples Hospital
Current assignee: Qingdao Third Peoples Hospital
Priority date: 2015-12-25
Filing date: 2015-12-25
Publication date: 2016-04-20

Abstract

The invention provides a Chinese herb preparation for treating intestinal obstruction and a preparation method thereof. The Chinese herb preparation is prepared from snakegourd seeds, herb of serissa serissoides, niter, black bamboo roots, mirabilite, peach flowers, semen calonyctionis muricati, Japanese snakegourd roots, seeds of turnip, stems of rheum officinale Baill., fruits of polygonum orientale, copperas, Henry clematis roots, roots of isotrema transsecta Chatt., immature fruits of citus grandis, rhizomes of Chinese galangal, fruits of white perilla, straw, fruit-spikes of betel pepper, rhizoma bolbostemmae, radix mirabilis, herb of basella rubra L., herb of polygonum divaricatum L. and seeds of pinus koraiensis Sieb. et Zucc.. The Chinese herb preparation for treating intestinal obstruction has the advantages of being good in treatment effect when used in cooperation with a conventional Western medicine treatment method, free of toxic and side effects and simple in preparation process.

Description

Traditional Chinese medicine preparation for treating intestinal obstruction and preparation method thereof

Technical Field

The invention relates to the technical field of traditional Chinese medicine engineering, in particular to a traditional Chinese medicine preparation for treating intestinal obstruction and a preparation method thereof.

Background

Ileus refers to the obstruction of the passage of intestinal contents in the intestinal tract. The acute abdomen disease is a common acute abdomen disease and can be caused by various factors, the anatomical and functional changes of an obstructed intestinal section at the beginning of the disease, the loss of body fluid and electrolyte, the circulatory disturbance of the intestinal wall, necrosis and secondary infection occur, and finally, toxemia, shock and death can be caused. The treatment of intestinal obstruction consists in relieving the obstruction and restoring the smoothness of the intestinal canal. It is worth noting that the life-threatening aspect of the patient is not solely due to ileus itself, but rather to the systemic pathophysiological changes caused by ileus. In order to save the life of a patient, the water and electrolyte disorder should be corrected in time to reduce the intestinal cavity expansion. Ileus refers to a group of clinical symptoms caused by the failure of intestinal contents to normally run and smoothly pass through the intestinal tract, and is a common surgical disease. The western medicine considers that the pathological changes of intestinal obstruction are intestinal intracavity swelling, pneumatosis and hydrops, bacteria are propagated in a large quantity to generate a large quantity of toxins, and meanwhile, the intestinal wall is congested and edematous, the venous blood flow is blocked to generate blood disorder, intestinal adhesion after operation is one of the main reasons for causing the intestinal obstruction, when inflammatory reaction caused by any reason exists in the intestinal cavity, congestion and edema are locally released, histamine, various kinins and other blood vessel-derived substances are released, and a large quantity of cellulose exudation cells generate collagen which becomes the basis of fibrous adhesion, so that secondary adhesion can be generated after secondary operation.

The clinical manifestations of ileus are mainly: (1) abdominal pain: is paroxysmal angina. Ileus of jejunum or upper ileum attacks 1 time every 3-5 minutes, ileus of terminal ileum or large intestine attacks 1 time every 6-9 minutes, pain is relieved in the intermittent period of the attack, and the period of colic is accompanied by hyperthyroidism. (2) Vomiting: after obstruction, the retrograde motion of the intestinal tract causes vomiting in the patient. (3) Abdominal distension: most of the ileus occurs in the late stage, the high-level small intestine obstruction is not obvious as that of the low-level small intestine obstruction, the ileus of the colon rarely generates reflux due to the existence of the ileocecal valve, and the obstruction is usually of a closed loop nature, so the abdominal distension is obvious. (4) Exhaust and defecation stop: patients with intestinal obstruction generally stop defecation and exhaustion through the anus. However, mesenteric vascular embolization and intussusception can drain loose stool or bloody mucus.

Ileus belongs to the category of "intestine knot" and "guan ge" in traditional Chinese medicine. The formula recorded in Zhongzhanzhongxi recorded and cured dryness accumulation in medicine includes that the food is stopped in the intestine and does not cause pain, so the term "intestine accumulation". Shanghai treatise on Cold-induced diseases and Yang-Ming syndrome differentiation syndrome cloud: the food cannot be eaten, so the product is named as a barrier. The relevant description in the "internal classic" is: "diet failing to keep the diaphragm blocked and pathogenic factors in the stomach". "if the person is closed, neither the one is nor the other is true". The traditional Chinese medicine considers that the intestinal canal is 'a house for transmission and transformation', and can transmit, digest and transport food. The physiological features of the intestine are "purgative but not in storage", "move but not still", "descend but not rise", "excess but not full", and in short, smooth descending behavior. If the disorder of qi and blood circulation caused by qi and blood stagnation and cold, heat accumulation, cold stagnation, food and insect retention can lead to the stagnation of qi and blood in the intestinal tract and the adverse rising of cold, the disease can be manifested as pain, vomiting, distention and block. Pain is caused by qi and blood stagnation, swelling is caused by qi stagnation, intestinal tract is blocked, vomiting is caused by obstruction of qi in the upper part, and downward flow is smooth.

Disclosure of Invention

The invention aims to solve the technical problem of providing a traditional Chinese medicine preparation for treating intestinal obstruction with definite curative effect and small toxic effect and a preparation method thereof by utilizing the traditional Chinese medicine theory in China.

In order to solve the technical problems, the invention provides a traditional Chinese medicine preparation for treating intestinal obstruction, which comprises the following raw material medicines: semen Trichosanthis, fructus Mali Pumilae, Sal Nitri, radix Phyllostachydis Henonis, fructus Cynanchi Stauntonii, flos persicae, fructus Solani Melongenae, radix Trichosanthis, caulis et folium Rhei, fructus Polygoni orientalis, Melanteritum, fructus Chebulae, semen Oroxyli, exocarpium Citri rubrum, rhizoma Zingiberis recens, fructus Perillae Frutescentis, caulis et folium oryzae, caulis et folium Piperis Hancei, rhizoma Bolbostematis, herba Basellae, herba Potentillae Discoloris and semen Pini koraiensis.

The weight part ratio of various raw medicinal materials in the traditional Chinese medicine preparation can be preferably as follows: 20-35 parts of trichosanthes kirilowii maxim, 20-30 parts of serissa serissoides, 15-25 parts of gypsum, 30-40 parts of phyllostachys edulis, 15-30 parts of cynanchum glaucescens, 10-25 parts of sodaapple nightshade, 15-25 parts of king cucumber root, 10-20 parts of turnip seed, 25-35 parts of rhubarb stem, 30-40 parts of princesplume ladysthumb fruit, 5-15 parts of copperas, 20-30 parts of henry, 15-25 parts of buttercup root, 10-20 parts of margaria, 10-20 parts of margarita, 10-25 parts of lima ginger, 15-30 parts of perilla frutescens, 20-30 parts of straw, 20-35 parts of betel sauce, 10-20 parts of rhizoma boldii, 15-25 parts of mirabilis, 20-30 parts of mallow, 25-35 parts of tamarind and 20-35 parts of.

The weight part ratio of the raw medicinal materials in the traditional Chinese medicine preparation can be further optimized as follows: 30-35 parts of trichosanthes kirilowii maxim, 25-30 parts of serissa serissoides, 15-20 parts of gypsum, 30-35 parts of phyllostachys edulis, 25-30 parts of cynanchum glaucescens, 20-25 parts of peach blossom, 15-20 parts of sodaapple nightshade, 20-25 parts of royal jelly root, 10-15 parts of turnip seed, 25-30 parts of rhubarb stem, 35-40 parts of princesplume ladysthumb, 5-10 parts of copperas, 20-25 parts of henry, 15-20 parts of buttercup root, 10-15 parts of margaria, 10-15 parts of margarita, 15-20 parts of cirrus formosana, 15-20 parts of salmon ginger, 20-25 parts of perilla frutescens, 25-30 parts of straw, 30-35 parts of betel sauce, 10-15 parts of rhizoma boldii, 15-20 parts of mirabilis japonicas.

The weight part ratio of various raw medicinal materials in the traditional Chinese medicine preparation can also be further optimized as follows: 35 parts of trichosanthes kirilowii maxim, 26 parts of serissa serissoides, 19 parts of gypsum, 32 parts of black bamboo root, 29 parts of puelia, 22 parts of peach blossom, 19 parts of soda-apple night-shade herb, 21 parts of king melon root, 15 parts of turnip seed, 26 parts of rhubarb stem, 39 parts of prince's-feather fruit, 6 parts of green vitriol, 25 parts of henry clematis root, 16 parts of buttercup fruit, 15 parts of tangerine bead, 16 parts of lima ginger, 25 parts of perilla frutescens fruit, 26 parts of straw, 34 parts of betel sauce, 12 parts of bolbostemma paniculatum, 19 parts of mirabilis root, 26 parts of mallow, 29 parts of acid regurgitation and 26 parts of sea.

When the dosage form of the traditional Chinese medicine preparation is granules, the preparation method comprises the following steps:

the method comprises the following steps: mixing the raw material medicines according to the proportion, adding ethanol with the alcohol concentration of 80-95% which is 5-6 times of that of the mixture, heating to boil and refluxing for 4-6 hours, filtering, slowly percolating at the speed of 1-2 ml per minute by using a percolation method with reflux liquid as a solvent and filter residue as a solute, collecting percolate, then concentrating under reduced pressure at the vacuum degree of 0.06-0.08 Mpa to a paste with the relative density of 1.05-1.10 at the temperature of 50-60 ℃, spray drying, and crushing the paste into powder to prepare dry paste powder, wherein the air inlet temperature of a spray dryer is 160-175 ℃, and the air outlet temperature is 80-85 ℃;

step two: adding sucrose powder 0.2-0.4 times of the dry extract powder and dextrin 0.1-0.2 times of the dry extract powder into the obtained dry extract powder, preparing granules, and drying at 40-50 ℃ to obtain the granules.

When the dosage form of the traditional Chinese medicine preparation is a capsule, the preparation method comprises the following steps:

mixing trichosanthes kirilowii maxim, serissa serissoides, lithospermum and arundina chinensis and cynanchum obovatum according to the proportion, adding 4-6 times of water to extract volatile oil, including the obtained volatile oil with beta-cyclodextrin, wherein the proportion of the volatile oil to the beta-cyclodextrin is 1: 3-6, stirring for 75-90 minutes, and keeping the temperature at 30-50 ℃ to obtain a volatile oil inclusion compound for later use; concentrating the water extract to obtain a clear paste with the relative density of 1.15-1.17 at 60 ℃;

secondly, mixing the radix cucurbitae, the turnip seed, the rhubarb stem, the copperas, the chervil, the butterfly dark girl and the rhizoma zingiberis recens according to the proportion, adding ethanol with the alcohol concentration of 80-90% which is 6-8 times of that of the mixture, performing reflux extraction for 3-5 times, performing 2-3 hours each time, filtering, combining filtrates, recovering ethanol, and concentrating to obtain a clear paste with the relative density of 1.20-1.22 at 60 ℃ for later use;

thirdly, mixing the rest raw medicinal materials according to the proportion, adding 8-10 times of water relative to the mixture, boiling for 6-8 hours, filtering, and concentrating to obtain clear paste with the relative density of 1.28-1.30 at 65 ℃;

fourthly, mixing the clear pastes obtained in the first step, the second step and the third step, and drying the mixture in vacuum at 60-70 ℃ under reduced pressure to obtain dry paste powder;

and fifthly, fully mixing the volatile oil inclusion compound obtained in the first step with the dry paste powder obtained in the fourth step, then adding 5-8 parts by weight of sodium carboxymethyl starch and 10-50 parts by weight of starch to 100 parts by weight of the mixture of the volatile oil inclusion compound and the dry paste powder, uniformly mixing, adding 150-200 parts by weight of ethanol with the alcohol concentration of 80% -90%, granulating, drying, grading, then adding 3-5 parts by weight of magnesium stearate to 100 parts by weight of the mixture of the volatile oil inclusion compound and the dry paste powder, and then filling into gelatin capsules.

The traditional Chinese medicine preparation for treating intestinal obstruction has the advantages of good treatment effect, no toxic or side effect and simple preparation process when used in combination with a conventional western medicine treatment method.

Detailed Description

The invention provides a traditional Chinese medicine preparation for treating intestinal obstruction, which comprises the following raw material medicines: semen Trichosanthis, fructus Mali Pumilae, Sal Nitri, radix Phyllostachydis Henonis, fructus Cynanchi Stauntonii, flos persicae, fructus Solani Melongenae, radix Trichosanthis, caulis et folium Rhei, fructus Polygoni orientalis, Melanteritum, fructus Chebulae, semen Oroxyli, exocarpium Citri rubrum, rhizoma Zingiberis recens, fructus Perillae Frutescentis, caulis et folium oryzae, caulis et folium Piperis Hancei, rhizoma Bolbostematis, herba Basellae, herba Potentillae Discoloris and semen Pini koraiensis.

The pharmacology of various raw medicinal materials is as follows:

trichosanthes seed: [ ALDEM ] semen Trichosanthis, and semen Trichosanthis. [ SOURCE ] medicinal material base source: is seed of Trichosanthes kirilowii Maxim and Trichosanthes sinense Maxim of Cucurbitaceae. [ PROPERTIES AND FLAVOUR ] sweet in taste; slightly bitter; is cold in nature. [ GUIJING ] belongs to the lung; the stomach; the large intestine channel. [ FUNCTIONS ] can clear lung-heat and resolve phlegm; to smooth the intestines and relax the bowels. Cough due to dominant phlegm; cough due to lung deficiency; constipation due to intestinal dryness; abscess, sore and pyogenic infections. [ discussions of the respective households ] 1. Rihuazi Ben Cao: tonify consumptive disease, dry mouth, moisten heart and lung. Treating hand and face wrinkles, hematemesis, intestinal wind and bloody discharge, and red and white dysentery. 2. The herbal Meng quan: tonify lung and descend qi, remove dirt and relieve depression. Treating cold accumulation in chest, deficiency, timidity, tuberculosis and cough; quenching thirst and promoting the production of body fluid; stop bleeding. 3. The book of Traditional Chinese Medicine (TCM) (J: it is used for treating constipation of intestine and colon in the elderly or after illness. [ extract ] China materia Medica

White horse bone: [ SOURCE ] medicinal material base source: is a whole plant of dicotyledonous plant, such as white horse bone or serissa serissoides of Rubiaceae. [ PROPERTIES AND FLAVOUR ] bitter and pungent; cooling; is nontoxic. [ GUIJING ] liver; spleen meridian. [ FUNCTIONAL INDICATIONS ] dispel pathogenic wind; removing dampness; clearing away heat; and (5) detoxifying. Treating common cold; icteric hepatitis; edema due to nephritis; cough; sore throat; keratitis; enteritis; dysentery; pain in the waist and legs; hemoptysis; hematuria; amenorrhea in women; leucorrhea; infantile malnutrition; convulsion; toothache due to wind-fire evil; abscess, deep-rooted carbuncle and pyogenic infections; traumatic injury. [ discussion of each family ] 1, Guangzhou army 'handbook of common Chinese herbal medicine': soothing liver, relieving depression, clearing away heat, promoting diuresis, relieving swelling, and removing toxic materials. It can be used for treating acute and chronic hepatitis, rheumatic lumbago, skelalgia, carbuncle, swelling, skin ulcer, and snake bite. 2. A manual of Chinese herbal medicines commonly used in Shanghai: promoting blood circulation, relieving swelling, dispelling pathogenic wind, eliminating dampness, and strengthening body constitution. It is indicated for amenorrhea, leukorrhagia, dizziness and weakness.

Stone removal: [ SOURCE ] medicinal material base source: is a crystal or an artificial product which is prepared by processing and refining nitrate saltpeter mineral potassium saltpeter. [ PROPERTIES AND WESTERN ] bitter and salty; and (4) warming. [ GUIJING ] XIN; a spleen; the lung meridian. [ FUNCTIONS ] can break hardness and dissipate stagnation; diuresis and purgation; detoxify and detumescence. Mainly treating heatstroke and cold injury; eruptive disease; pain in the heart and abdomen; vomiting and diarrhea; jaundice; the symptoms and the volume; gonorrhea; constipation; conjunctival congestion; pharyngitis; furunculosis; abscess and swelling. [ discussions of the respective households ] 1, the book of academic Press: the five zang organs accumulate heat and the stomach is distended and closed, and the retention is cleared away, the accumulation is accumulated, the food is drunk, the five zang organs are aged and become new, and pathogenic qi is removed. 2. Treatise on herb Property: scrofula mainly manifests itself by diarrhea, bleeding, accumulation, dissipating hardness and nodulation, and is indicated for abdominal distension. 3. The herbal Meng quan: moisten dryness and soften hardness, purge excess. 4. Compendium (compendium): it is indicated for cold due to summer-heat, cholera and vomiting, five kinds of stranguria, female black jaundice, cardialgia, red eye swelling and pain, and toothache. [ extract ] China materia Medica (Chinese materia Medica)

Root of purple bamboo: [ SOURCE ] medicinal material base source: is rhizome of Phyllostachys nigra of Gramineae. [ PROPERTIES AND FLAVOURS ] XIN; diluting; and (6) cooling. [ FUNCTIONS ] can dispel pathogenic wind and dampness; promoting blood circulation and removing toxic substance. Wind-damp-heat arthralgia; soreness of bones and muscles; amenorrhea; (iii) a symptom; rabies. [ discussions of the respective households ] Chongqing herbal medicine: move qi and break food stagnation, clear liver heat from wind-heat. For stagnation of qi and blood, mass accumulation and menopause. [ extract ] China materia Medica

Naive: [ ALSAGE ] cortex Magnoliae officinalis, sea weed, Mirabilitum, PIXIAO, SAIXIAO, SHUIXIAO, HAIPIAO, and MAOXIAO. [ SOURCE ] medicinal material base source: is crude product of sulfate salt mirabilite, mineral mirabilite or artificial product mirabilite. [ PROPERTIES AND FLAVOURS ] XIN; bitter and salty; is cold. [ GUIJING ] DIGEN (stomach); the large intestine channel. [ FUNCTIONS ] can purge heat and moisten dryness; clearing heat and relieving swelling; soften hardness and dissipate nodulation. Dominant excess heat retention; abdominal distension and constipation; stopping phlegm accumulation; conjunctival congestion with swelling and pain; pharyngitis; abscess and swelling; breast swelling; swelling and pain of hemorrhoid; stopping phlegm accumulation; abdominal pain due to blood stasis in women. [ extract ] China materia Medica (Chinese materia Medica)

Peach blossom: [ SOURCE ] medicinal material base source: is flower of Prunus persica or Prunus davidiana of Rosaceae. [ PROPERTIES AND FLAVOUR ] bitter; and (7) flattening. [ GUIJING ] XIN; liver; the large intestine channel. [ FUNCTIONAL INDICATIONS ] disinhibiting water; promoting blood circulation and removing blood stasis. Major edema; beriberi; phlegm-fluid retention; promoting diuresis and relaxing bowels; spraying sand and stone; constipation; amenorrhea; mania; sores and rashes. [ discussions of the respective households ] 1 the bibliography: it is mainly used to remove water vapor, break stone and stranguria, relieve constipation and expel three insects. 2. Tang Ben Cao (materia Medica of Tang Dynasty): mainly descend foul breath, eliminate swelling and benefit large and small intestines. 3. Compendium (compendium): induce diuresis and phlegm retention. It is indicated for mania. 4. Compendium (compendium): peach blossom, being quick in promoting sexuality, promoting urination and defecation, is harmless and effective in treating excess qi patients with edema, stagnation of fluid and obstruction of urination and defecation, and can consume yin blood and lose primordial qi if taken for a long time. [ extract ] China materia Medica

And (3) soda-apple night-shade herb: [ SOURCE ] medicinal material base source: is seed of Solanum caryophyllum L of Convolvulaceae. [ PROPERTIES AND FLAVOUR ] bitter; is cold. [ FUNCTIONAL INDICATIONS ] purgative; and (3) detoxifying snake venom. Constipation in major cases; bite by poisonous snake. [ extract ] China materia Medica

And (3) root of king cucumber: [ alternative name ] fructus seu semen haii, fructus haii, pollen, fructus Momordicae charantiae, and semen Trichosanthis Cucumeroidis. [ SOURCE ] medicinal material base source: is seed of Trichosanthes Kitagawa of Compositae. [ PROPERTIES AND FLAVOUR ] bitter in taste; is cold in nature. [ GUIJING ] belongs to the large intestine; the stomach meridian. [ FUNCTIONS ] RELIEF HEAT-RELEASING AND JIE CONE-TRANSITION; dispel stasis and relieve swelling. Polydipsia due to major heat; jaundice; constipation due to heat accumulation; difficulty in urination; amenorrhea; the milk does not fall; (iii) a symptom; abscess and swelling. [ discussions of the respective households ] 1. Rihuazi Ben Cao: promoting blood circulation, activating the heat in the sky, treating alcohol jaundice, strengthening heat, vexation, oppression, expelling pus, and relieving internal heat. For threatened abortion, blood stasis, dry stool and blood stasis. 2. Compendium (compendium): relieve constipation and treat skin ulcer. [ extract ] China materia Medica

Turnip seed: [ alternative name ] Brassica napus seed. [ SOURCE ] medicinal material base source: is seed of Brassicaceae plant radix Brassicae Rapae. [ PROPERTIES AND FLAVOURS ] XIN; bitter; is cold. [ GUIJING ] liver; a spleen; a lung; the large intestine channel. [ FUNCTIONS ] can nourish liver and improve vision; promoting qi circulation and inducing diuresis; clearing away heat and toxic material. (iii) blind dominance; the eyes are dark; jaundice constipation; difficulty in urination; the symptoms and the volume; sores and deep-rooted carbuncle. [ discussions of the families ] 1. wash: it is indicated for heat yellow with hard mass. 2. Treatise on medilin: benefiting liver qi, activating qi-flowing, removing stagnated heat, eliminating accumulation and killing parasites and viruses. [ extract ] China materia Medica

Rhubarb stem: [ SOURCE ] medicinal material base source: is overground stem or seedling of Rheum palmatum L.var.tanguticum Maxim, Rheum tanguticum Maxim or Rheum officinale Baill. [ PROPERTIES AND FLAVOUR ] bitter; an acid; is cold in nature. [ FUNCTIONS ] can purge pathogenic fire; and (5) relaxing the bowels. Constipation due to excess heat. [ discussion of each family ] Chinese medical dictionary: relieve constipation and clear intestinal heat. [ extract ] China materia Medica

Fructus polygoni orientalis: [ alias ] Oriental knotweed, Japanese knotweed, Setaria viridis, and Setaria chamaejasme. [ SOURCE ] the product is dry mature fruit of Polygonum hydropiper L.of Polygonaceae. [ PROPERTIES AND FLAVOUR ] salty in taste and slightly cold in nature. [ GUIJING ] enters liver and stomach meridians. [ FUNCTIONS ] can dispel blood, eliminate stagnation, and relieve pain. Can be used for treating lump, gall, dyspepsia, and gastralgia. [ extract ] Chinese pharmacopoeia

Green vitriol: [ alias ] Melanteritum, and Melanteritum. [ SOURCE ] medicinal material base source: is mineral of sulfate type Melanteritum or its artificial product (JIANGFAN). [ PROPERTIES ] ACID; astringency; cold; is nontoxic. [ GUIJING ] FEN (Lung-meridian tropism) lung; liver; a spleen; the large intestine channel. [ FUNCTIONS INDICATION ] can eliminate dampness and kill parasites; enriching blood and removing food retention; detoxify and heal wound. Sallow complexion due to deficiency of the blood; malnutrition; abdominal distension and fullness; hematochezia due to intestinal wind; ulceration of sores; sore throat and aphtha; rotten wind eyes; scabies, tinea and pruritus. [ discussion of the various families ] compendium: the recipe can eliminate stagnation, dryness-spleen dampness, phlegm and saliva, and relieve the symptoms of fullness and distention, yellow swelling, malaria, wind-eyes and mouth and teeth. [ extract ] China materia Medica (Chinese materia Medica)

Snow lining: [ alternative name ] flos Centellae, herba Desmodii Multifloi, semen Hoveniae, and semen Serissae. [ SOURCE ] medicinal material base source: is root or leaf of Monopterospermum flabellatum of Ranunculaceae. [ PROPERTIES AND FLAVOURS ] XIN; bitter; is cool in nature. [ GUIJING ] XIN; a lung; the stomach meridian. [ FUNCTIONAL INDICATIONS ] can clear away heat and toxic materials; eliminating phlegm and relieving cough; promoting qi and blood circulation; can be used for relieving pain. High fever and infantile convulsions mainly occur; cough; swollen and sore throat; headache; stomach pain; abdominal pain; traumatic injury; parotitis; furunculosis and furuncle; snake bite. [ extract ] China materia Medica

Hidden elimination of butterfly: [ alias ] radix aucklandiae, caulis Sinomenii, fructus Tribuli and fructus Vitis Viniferae, and fructus Vitis Viniferae are used for eliminating endogenous fire. [ SOURCE ] medicinal material base source: is root of Aristolochia debilis of Aristolochiaceae. [ PROPERTIES AND FLAVOUR ] bitter; astringency; and (4) warming. [ FUNCTIONS ] CHARGING BUILD-UP Qi and alleviate pain; dispelling wind and eliminating dampness. Food stagnation in the major qi; stomach pain; abdominal distension; rheumatic arthralgia. [ extract ] China materia Medica

Orange bead: [ alias ] orange bead and orange embryo. [ SOURCE ] medicinal material base source: is the young fruit of Citrus paradisi of Rutaceae. [ PROPERTIES AND FLAVOURS ] WEI ACID; bitter; and (4) warming. [ GUIJING ] liver; a spleen; the stomach meridian. [ FUNCTIONS ] can promote the circulation of qi and remove food stagnation. Stagnation of the main diet; and (4) symptoms. [ discussion of the various families ] Guangxi Chinese materia medica Zhi (records of Chinese materia Medica in Guangxi): quench thirst, help digestion and remove qi stagnation in chest. It is indicated for food stagnation and abdominal mass. [ extract ] China materia Medica

Fresh ginger: [ ALSAL ] Subspini, JIANGHUI, rhizoma Alpiniae Officinarum, herba Epimedii, and rhizoma Coptidis. [ SOURCE ] medicinal material base source: is rhizome of Alpinia zerumbet belonging to Zingiberaceae. [ PROPERTIES AND FLAVOUR ] pungent in flavor; and (4) temperature. [ GUIJING ] spleen; the stomach; the liver meridian. [ FUNCTIONS ] can warm the middle-jiao to promote digestion; dispelling cold and relieving pain; promoting blood circulation; relieving cough and asthma. Cold and cold pain in the stomach; dysphagia and vomiting; abdominal pain, diarrhea, dyspepsia; rheumatic joint crymodynia; traumatic injury; cough and asthma due to wind-cold evil. [ discussions of the respective households ] 1 the compendium: warm the middle-jiao and lower qi, promote digestion and benefit intelligence. 2. The famous records of Guangxi drug implantation: it is indicated for stomach cold, dysphagia, vomiting, abdominal pain, diarrhea and dyspepsia. [ extract ] China materia Medica

White perilla seed: [ ALSAGE ] Perilla frutescens seed and bamboo. [ SOURCE ] medicinal material base source: is fruit of Perilla frutescens of Labiatae, a dicotyledonous plant drug. [ PROPERTIES AND FLAVOURS ] XIN; warming; is nontoxic. [ GUIJING ] FEN (Lung-meridian tropism) lung; a spleen; the large intestine channel. [ FUNCTIONS ] can discharge qi; eliminating phlegm; moistening lung; the intestine is wide. Cough with dyspnea; asthma due to phlegm; constipation due to qi stagnation. [ discussion of the various families ] decoction piece Xin Shen: pacify lung qi and check contrary. For cough and dyspnea, it is indicated for intestinal obstruction. [ extract ] China materia Medica

Straw: [ alias ] Rice stalks, Rice straw, straw. [ SOURCE ] medicinal material base source: is stem and leaf of Gramineae plant rice and glutinous rice. [ PROPERTIES AND FLAVOURS ] XIN; and (4) warming. [ GUIJING ] spleen; the lung meridian. [ FUNCTIONS ] with wide and moderate scope; discharging gas; promoting digestion; and (5) detoxifying. Dysphagia; regurgitation; food stagnation; abdominal pain; diarrhea; quenching thirst; jaundice; pharyngitis; hemorrhoids; scald. [ extract ] China materia Medica

Betel sauce: [ alias ] betel jam, betel and betel nut. [ SOURCE ] medicinal material base source: is the fruit ear of Piper betle of Piperaceae. [ PROPERTIES AND FLAVOURS ] XIN; and (4) warming. [ GUIJING ] FEN (Lung-meridian tropism) lung; spleen meridian. [ FUNCTIONS ] can warm the middle-jiao and lower qi, resolve phlegm and dissipate nodulation, and alleviate pain. Cold pain in the abdomen, vomiting, diarrhea, abdominal pain due to parasitic infestation, cough, dyspnea, and toothache. [ discussion of each family ] 1, dietetic herbal: disperse accumulation of qi and treat cold in the heart and abdomen. 2. The materia Medica of sea drugs: it is mainly indicated for cough, dyspnea, abdominal pain, stomach weakness, diarrhea, cholera, vomiting, sobering up and eating. [ extract ] China materia Medica

Paniculate Bolbostemma rhizome: [ SOURCE ] the product is dried tuber of Bolbostemma paniculatum of Cucurbitaceae. [ PROPERTIES AND FLAVOUR ] bitter and slightly cold. [ GUIJING ] enters lung and spleen meridians. [ FUNCTIONS ] can dissipate stagnation, relieve swelling, and remove toxicity. Can be used for treating acute mastitis, scrofula, mastitis, tuberculosis of cervical lymph nodes, chronic lymphadenitis, and hypertrophic rhinitis. [ extract ] Chinese pharmacopoeia

Radix Mirabilis: [ ALSAGE ] BAIHUASHEN, radix Stephaniae Cepharanthae, semen Sinapis Albae, flos Bidentis Bipinnatae, radix Erysipheae Divaricatae, and fructus Canarii albi. [ SOURCE ] medicinal material base source: is root of Mirabilis jalapa of Mirabilis. [ PROPERTIES AND FLAVOURS ] sweet; diluting; slightly cold in nature. [ FUNCTIONS ] can clear away heat and promote diuresis; detoxicate and activate blood. Performing main heat shower; white turbidity; edema; leucorrhea with reddish discharge; joint swelling and pain; carbuncle sore and pyogenic infections; acute mastitis; traumatic injury. [ discussions of the respective families ] Nanning City medical records: antipyretic, slow purgation, removing blood stasis, regulating menstruation. It is indicated for cough and hemoptysis due to lung fatigue. [ extract ] China materia Medica

And (3) sunflower: [ SOURCE ] medicinal material base source: is leaf or whole plant of herba Basellae Rubrae of Malvaceae. [ PROPERTIES AND FLAVOURS ] sweet; an acid; is cold in nature. [ FUNCTIONAL INDICATIONS ] can smooth intestines and relieve constipation; clearing heat and promoting diuresis; cooling blood and removing toxic substance; promoting blood circulation. Constipation in major cases; short and astringent urine; dysentery; sores and ulcers due to heat-toxin; traumatic injury. [ extract ] China materia Medica

Acid is not easy to run: [ ALDENSE ] SUANJIANG, SUANHAN pulp, and SUANJIANG. [ SOURCE ] medicinal material base source: is the whole plant of herba Polygoni Avicularis of Polygonaceae. [ PROPERTIES ] ACID; bitter; is cool in nature. [ FUNCTIONS ] can clear heat and eliminate dampness; soften hardness and dissipate nodulation. Diarrhea due to damp-heat; dysentery; gall and gall tuberculosis. [ extract ] China materia Medica

Sea pine nuts: [ ALDETAE ] semen pini koraiensis, and semen pini koraiensis. [ SOURCE ] medicinal material base source: is seed of Pinus koraiensis of Pinaceae. [ PROPERTIES AND FLAVOURS ] sweet; mild in nature. [ GUIJING ] liver; a lung; the large intestine channel. [ FUNCTIONS ] can moisten dryness, nourish blood, and dispel pathogenic wind. It is mainly indicated for dry cough due to lung dryness, constipation, wind-syndrome, dizziness, wind-syndrome of bone and arthralgia due to wind-cold. It also has effects in moistening skin and caring hair. [ discussions of the respective families ] 1, Yu catalpa Yao Jie (Yao's medical solution): like Baizi ren, Songzi ren is astringent and moist, moistens lung and relieves cough, and smoothes intestine and keeps the bowels secret. It is also good at treating arthralgia syndrome due to wind-damp and good at nourishing skin and hair. 2. The materia Medica of sea drugs: mainly dispel wind, warm intestines and stomach. 3. The herbal medicine Tongxian: to tonify lung and relieve cough, to tonify qi and nourish blood, moisten intestine to quench thirst, warm middle energizer and search wind. [ extract ] China materia Medica

The following embodiments are described in detail to solve the technical problems by applying technical means to the present invention, and the implementation process of achieving the technical effects can be fully understood and implemented.

Example 1: granules prepared by the invention

350g of trichosanthes kirilowii maxim, 260g of serissa serissoides, 190g of gypsum, 320g of purple bamboo root, 290g of cynanchum glaucescens, 220g of peach blossom, 190g of soda-apple night-shade herb, 210g of king melon root, 150g of turnip seed, 260g of rhubarb stem, 390g of princesplume ladysthumb fruit, 60g of green vitriol, 250g of henry clematis root, 160g of butterfly dark herb, 150g of chrysoidine bead, 160g of rhizoma zingiberis, 250g of perilla frutescens, 260g of straw, 340g of betel sauce, 120g of rhizoma bolbostemmae, 190g of mirabilis japonicas root, 260g of mallow-fruit.

The preparation method comprises the following steps:

the method comprises the following steps: mixing the raw material medicines according to the proportion, adding ethanol with the concentration of 85% relative to 5 times of the mixture, heating to boil and reflux for 5 hours, filtering, slowly percolating at the speed of 2ml per minute by using a percolation method by using the reflux liquid as a solvent and filter residue as a solute, collecting the percolate, then concentrating under reduced pressure at the vacuum degree of 0.08Mpa to obtain a paste with the relative density of 1.05 at the temperature of 55 ℃, spray drying, and crushing into powder at the air inlet temperature of 165 ℃ and the air outlet temperature of a spray dryer, thus preparing dry paste powder;

step two: adding sucrose powder 0.3 times and dextrin 0.2 times of the dry extract powder into the obtained dry extract powder, granulating, and drying at 45 deg.C to obtain granule.

Example 2: the capsule prepared by the invention

310g of trichosanthes kirilowii maxim, 280g of serissa serissoides, 160g of gypsum, 350g of purple bamboo root, 260g of cynanchum glaucescens, 250g of peach blossom, 160g of soda-apple night-shade herb, 250g of king melon root, 120g of turnip seed, 300g of rhubarb stem, 360g of princesplume ladysthumb fruit, 100g of green vitriol, 210g of henry clematis root, 190g of butterfly dark herb, 120g of chrysoidine bead, 200g of rhizoma zingiberis, 220g of perilla frutescens, 290g of straw, 320g of betel pepper sauce, 150g of rhizoma bolbostemmae, 160g of mirabilis root, 290g of mallow, 260g of acid.

The preparation method comprises the following steps:

firstly, mixing trichosanthes kirilowii maxim, serissa serissoides, lithospermum and arundina chinensis and cynanchum wilfordii according to the proportion, adding 5 times of water to extract volatile oil relative to the mixture, clathrating the obtained volatile oil with beta-cyclodextrin, wherein the proportion of the volatile oil to the beta-cyclodextrin is 1: 4, stirring for 80 minutes, and keeping the temperature at 40 ℃ to obtain a volatile oil clathrate compound for later use; concentrating the water extractive solution to obtain fluid extract with relative density of 1.16 at 60 deg.C;

secondly, mixing the radix cucurbitae, the turnip seed, the rhubarb stem, the copperas, the chervil, the butterfly dark and the rhizoma zingiberis recens according to the proportion, adding ethanol with the concentration of 85 percent which is 6 times of that of the mixture, refluxing and extracting for 4 times, 3 hours each time, filtering, combining the filtrates, recovering the ethanol, and concentrating to obtain clear paste with the relative density of 1.20 at the temperature of 60 ℃ for later use;

thirdly, mixing the rest raw medicinal materials according to the proportion, adding 9 times of water relative to the mixture, boiling for 8 hours, filtering, and concentrating to obtain clear paste with the relative density of 1.28 at 65 ℃;

fourthly, mixing the clear pastes obtained in the first step, the second step and the third step, and drying the mixture in vacuum at 65 ℃ to obtain dry paste powder;

and fifthly, fully mixing the volatile oil inclusion compound obtained in the first step with the dry paste powder obtained in the fourth step, then adding 6 parts by weight of sodium carboxymethyl starch and 30 parts by weight of starch to 100 parts by weight of the mixture of the volatile oil inclusion compound and the dry paste powder, uniformly mixing, adding 160 parts by weight of ethanol with the alcohol concentration of 85%, granulating, drying, grading, then adding 4 parts by weight of magnesium stearate to 100 parts by weight of the mixture of the volatile oil inclusion compound and the dry paste powder, and then filling into gelatin capsules.

Toxicity test:

acute toxicity test: acute toxicity tests were carried out using 60 mice, each half of the mice being male and female, weighing 25-35 g. Mice were randomly divided into two groups, i.e., a control group and an administration group, fasted for 12 hours before the experiment, the Chinese medicinal granules prepared in example 1 of the present invention were dissolved in water, gavage was performed (concentration of 8.87g crude drug/ml, maximum concentration) with a gavage volume of 5ml/kg (i.e., single administration dose of 44.35 crude drug/kg), the control group was administered with an equal amount of physiological saline 2 times a day at intervals of 6 hours, after administration, observation was continuously performed for 14 days, and the toxic reaction and the number of deaths of the mice were recorded. The experimental results show that: compared with a control group, the mice have no obvious difference after administration, and the mice have normal general conditions, diet, drinking water and weight increase after continuous observation for 14 days in the experiment. The granules LD50 of the invention is orally administrated to mice with a gastric lavage of more than 44.35 crude drugs/kg, and the maximum daily dose is 88.7 crude drugs/kg/day. The clinical dosage of the traditional Chinese medicine is 8.53g crude drug/day/person, the weight of an adult is measured by 60KG, and the average dosage of the traditional Chinese medicine is 0.142g crude drug/KG/day. According to the weight: the tolerance of the traditional Chinese medicine of the invention orally administrated by gavage is 625 times of the clinical dosage of the traditional Chinese medicine of the invention for mice (the average body weight is calculated by 30 g). Therefore, the traditional Chinese medicine has extremely low acute toxicity and safe clinical medication.

Long-term toxicity test: the granule of example 1 of the present invention was administered to three groups of mice (20 mice per group) with 13.25, 25.43 and 42.37g crude drug/kg continuously for 15 weeks (1.0ml/100g body weight, 2 times per day) and after 3 weeks off, the results showed that: the traditional Chinese medicine has no obvious influence on indexes such as hair, behaviors, excrement and urine, body weight, visceral weight, hemogram, liver and kidney functions, blood sugar, blood fat and the like of a mouse, and the visceral eye does not find out abnormal change and histological examination results show that after the traditional Chinese medicine is taken for 15 weeks and stopped for 3 weeks, all visceral organs of the mouse have no obvious change. The traditional Chinese medicine has low toxicity after long-term administration to mice, has no abnormal reaction after stopping administration, and is safe to apply.

Clinical data:

case selection: all 130 cases were outpatient and inpatient. All patients were randomized into treatment and control groups. Wherein,

treatment groups 65, 36 men and 29 women; age 21-68 years; the course of the disease is 1h-6 d. Control group 65, 34 men and 31 women; age 20-67 years; the course of the disease is 1h-7 d. The treated group and the control group have no obvious difference (P is less than or equal to 0.01) in age, sex, disease onset time and clinical symptoms and are comparable.

Diagnostic criteria: 1. most of the acute onset diseases, the typical clinical symptoms can be summarized as "pain, vomiting, distension and closure", i.e. abdominal pain, vomiting, abdominal distension, and stopping of the exhaust and defecation. Abdominal distension, intestinal type, peristaltic wave or asymmetric bulge can be seen in abdominal physical examination, the bowel sounds are increased and increased, and the excessive water sounds or the metallic sounds of high tone can be heard, such as the peritonitis can be seen when strangulation or perforation occurs. 2. Auxiliary inspection: (1) abdomen vertical and horizontal position X-ray plain film: the flatus abdomen in the horizontal position shows the flatus and the flatus in the vertical position shows a plurality of gas-liquid planes. If the abdominal cavity is oozed more, the intestinal space is obviously widened. The small intestinal obstruction can show the fish bone spur formed by the intestinal mucosa fold in the dilated intestinal canal, and the colon obstruction can show the dilated colon bag. (2) Abdominal CT: CT signs of ileus mainly include intestinal dilation, sudden changes in intestinal diameter, thickening of intestinal wall, changes in mesenteric vascular course and diffuse hyperemia, and abnormal changes outside the intestinal lumen, such as large amounts of ascites.

The treatment method comprises the following steps:

control group: adopts the conventional treatment method of western medicine. 1. Fasting, gastrointestinal decompression; 2. correct water, electrolyte disorder and acid-base balance disorder; 3. parenteral nutrition support (home albumin for hypoproteinemic patients); 4. use of a suitable antibiotic; 7 days is a course of treatment.

Treatment groups: on the basis of the conventional treatment of the western medicine of a control group, the granules of the traditional Chinese medicine embodiment 1 are orally taken simultaneously, 15g is taken each time, and 3 times a day; 7 days is a course of treatment.

The judgment standard of the curative effect is as follows: and (3) curing: after treatment, the clinical symptoms such as abdominal distension and abdominal pain of the patient disappear, normal exhaust is recovered, and the abdomen is normal through X-ray examination. The method has the following advantages: after treatment, the clinical symptoms of abdominal distension, abdominal pain and the like of a patient are obviously improved but not completely disappeared, the abdominal X-ray examination does not return to normal, and the phenomenon of slight inflation of liquid or intestinal canal can be reduced. And (4) invalidation: after treatment, the clinical symptoms of abdominal distension, abdominal pain and the like of the patient are unchanged, and even the peritonitis is caused by aggravation of the disease.

The treatment results are as follows: the statistics of the two groups after 7 days of treatment are shown in Table 1.

TABLE 1 comparison of clinical efficacy of the two groups after 7 days of treatment (unit: case)

Group of	Number of examples	Cure of disease	Improvement of life	Not cured	Total effective rate
						Treatment group	65	47	16	2	63(96.92％)
Control group	65	31	22	12	53(81.53％)

As can be seen from Table 1, the treatment group adopting the traditional Chinese medicine of the invention and cooperating with Western medicine for treating intestinal obstruction has significant improvement on the treatment effect compared with the control group.

The concrete cases are as follows: the male is admitted to be a hospital and is 34 years old, the patient has no obvious inducement to lower abdominal pain, is persistent angina, has pale complexion, no cold sweat, no radiating pain, nausea and no vomiting, and stops defecation and exhaust with the anus, and the patient comes to the hospital to see a doctor.

Adopts the conventional treatment method of western medicine. 1. Fasting, gastrointestinal decompression; 2. correct water, electrolyte disorder and acid-base balance disorder; 3. parenteral nutrition support (home albumin for hypoproteinemic patients); 4. the use of appropriate antibiotics prevents infection. 5. The granules in the embodiment 1 of the invention are orally taken for 3 times a day, 15g each time, clinical symptoms such as abdominal distension and abdominal pain of a patient disappear after 5 days of treatment, normal exhaust is recovered, and the abdomen is normal and cured by X-ray examination, and no relapse occurs after 3 months of follow-up.

All of the above mentioned intellectual property rights are first implemented and no restrictions are set on other forms of implementing the new product or method. Those skilled in the art will take advantage of this important information, and the foregoing will be modified to achieve similar performance. However, all modifications or alterations are based on the new products of the invention and belong to the reserved rights.

The foregoing is directed to preferred embodiments of the present invention, other and further embodiments of the invention may be devised without departing from the basic scope thereof, and the scope thereof is determined by the claims that follow. However, any simple modification, equivalent change and modification of the above embodiments according to the technical essence of the present invention are within the protection scope of the technical solution of the present invention.

Claims

1. The traditional Chinese medicine preparation for treating intestinal obstruction is characterized by comprising the following raw material medicines: semen Trichosanthis, fructus Mali Pumilae, Sal Nitri, radix Phyllostachydis Henonis, fructus Cynanchi Stauntonii, flos persicae, fructus Solani Melongenae, radix Trichosanthis, caulis et folium Rhei, fructus Polygoni orientalis, Melanteritum, fructus Chebulae, semen Oroxyli, exocarpium Citri rubrum, rhizoma Zingiberis recens, fructus Perillae Frutescentis, caulis et folium oryzae, caulis et folium Piperis Hancei, rhizoma Bolbostematis, herba Basellae, herba Potentillae Discoloris and semen Pini koraiensis.

2. The traditional Chinese medicine preparation as claimed in claim 1, wherein the raw material herbs comprise, by weight: 20-35 parts of trichosanthes kirilowii maxim, 20-30 parts of serissa serissoides, 15-25 parts of gypsum, 30-40 parts of phyllostachys edulis, 15-30 parts of cynanchum glaucescens, 10-25 parts of sodaapple nightshade, 15-25 parts of king cucumber root, 10-20 parts of turnip seed, 25-35 parts of rhubarb stem, 30-40 parts of princesplume ladysthumb fruit, 5-15 parts of copperas, 20-30 parts of henry, 15-25 parts of buttercup root, 10-20 parts of margaria, 10-20 parts of margarita, 10-25 parts of lima ginger, 15-30 parts of perilla frutescens, 20-30 parts of straw, 20-35 parts of betel sauce, 10-20 parts of rhizoma boldii, 15-25 parts of mirabilis, 20-30 parts of mallow, 25-35 parts of tamarind and 20-35 parts of.

3. The traditional Chinese medicine preparation as claimed in claim 1 or 2, wherein the raw material herbs comprise, by weight: 30-35 parts of trichosanthes kirilowii maxim, 25-30 parts of serissa serissoides, 15-20 parts of gypsum, 30-35 parts of phyllostachys edulis, 25-30 parts of cynanchum glaucescens, 20-25 parts of peach blossom, 15-20 parts of sodaapple nightshade, 20-25 parts of royal jelly root, 10-15 parts of turnip seed, 25-30 parts of rhubarb stem, 35-40 parts of princesplume ladysthumb, 5-10 parts of copperas, 20-25 parts of henry, 15-20 parts of buttercup root, 10-15 parts of margaria, 10-15 parts of margarita, 15-20 parts of cirrus formosana, 15-20 parts of salmon ginger, 20-25 parts of perilla frutescens, 25-30 parts of straw, 30-35 parts of betel sauce, 10-15 parts of rhizoma boldii, 15-20 parts of mirabilis japonicas.

4. The traditional Chinese medicine preparation as claimed in claims 1 to 3, wherein the raw material herbs comprise, by weight: 35 parts of trichosanthes kirilowii maxim, 26 parts of serissa serissoides, 19 parts of gypsum, 32 parts of black bamboo root, 29 parts of puelia, 22 parts of peach blossom, 19 parts of soda-apple night-shade herb, 21 parts of king melon root, 15 parts of turnip seed, 26 parts of rhubarb stem, 39 parts of prince's-feather fruit, 6 parts of green vitriol, 25 parts of henry clematis root, 16 parts of buttercup fruit, 15 parts of tangerine bead, 16 parts of lima ginger, 25 parts of perilla frutescens fruit, 26 parts of straw, 34 parts of betel sauce, 12 parts of bolbostemma paniculatum, 19 parts of mirabilis root, 26 parts of mallow, 29 parts of acid regurgitation and 26 parts of sea.

5. The Chinese medicinal preparation as claimed in claims 1 to 4, wherein the Chinese medicinal preparation is in the form of granules, and the preparation method comprises the following steps:

6. The Chinese medicinal preparation as claimed in claims 1 to 4, wherein the Chinese medicinal preparation is in the form of capsule, and the preparation method comprises the following steps:

7. A method for preparing the Chinese medicinal preparation of claims 1 to 4, wherein the Chinese medicinal preparation is in the form of granules, and the preparation method comprises the following steps:

8. A method for preparing the Chinese medicinal preparation of claims 1 to 4, wherein the Chinese medicinal preparation is in the form of capsules, and the preparation method comprises the following steps: