CN105496412A - Expiration inflammation monitoring method and device - Google Patents
Expiration inflammation monitoring method and device Download PDFInfo
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- CN105496412A CN105496412A CN201510881093.8A CN201510881093A CN105496412A CN 105496412 A CN105496412 A CN 105496412A CN 201510881093 A CN201510881093 A CN 201510881093A CN 105496412 A CN105496412 A CN 105496412A
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- 238000012544 monitoring process Methods 0.000 title claims abstract description 25
- 206010061218 Inflammation Diseases 0.000 title claims abstract description 24
- 230000004054 inflammatory process Effects 0.000 title claims abstract description 24
- 238000000034 method Methods 0.000 title claims abstract description 22
- 230000029058 respiratory gaseous exchange Effects 0.000 claims abstract description 18
- 238000004458 analytical method Methods 0.000 claims abstract description 12
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 82
- 239000007789 gas Substances 0.000 claims description 68
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 41
- 230000036391 respiratory frequency Effects 0.000 claims description 13
- 230000000241 respiratory effect Effects 0.000 claims description 10
- 238000012360 testing method Methods 0.000 claims description 9
- 239000001569 carbon dioxide Substances 0.000 claims description 8
- 230000001143 conditioned effect Effects 0.000 claims description 5
- 238000012937 correction Methods 0.000 claims description 5
- 230000002757 inflammatory effect Effects 0.000 claims description 5
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 claims description 4
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 claims description 4
- 238000005070 sampling Methods 0.000 claims description 4
- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 claims description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 2
- 230000002159 abnormal effect Effects 0.000 claims description 2
- 230000004087 circulation Effects 0.000 claims description 2
- 239000003546 flue gas Substances 0.000 claims description 2
- 229910000037 hydrogen sulfide Inorganic materials 0.000 claims description 2
- 238000012545 processing Methods 0.000 claims description 2
- 238000009736 wetting Methods 0.000 claims description 2
- 230000035565 breathing frequency Effects 0.000 abstract 1
- 210000003456 pulmonary alveoli Anatomy 0.000 abstract 1
- 229910002091 carbon monoxide Inorganic materials 0.000 description 7
- 206010002091 Anaesthesia Diseases 0.000 description 4
- 230000037005 anaesthesia Effects 0.000 description 4
- 238000002560 therapeutic procedure Methods 0.000 description 3
- 102000016761 Haem oxygenases Human genes 0.000 description 2
- 108050006318 Haem oxygenases Proteins 0.000 description 2
- 239000003994 anesthetic gas Substances 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 238000009423 ventilation Methods 0.000 description 2
- 239000004475 Arginine Substances 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 241001024304 Mino Species 0.000 description 1
- 238000005085 air analysis Methods 0.000 description 1
- 208000037883 airway inflammation Diseases 0.000 description 1
- 229940035674 anesthetics Drugs 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- VTVVPPOHYJJIJR-UHFFFAOYSA-N carbon dioxide;hydrate Chemical compound O.O=C=O VTVVPPOHYJJIJR-UHFFFAOYSA-N 0.000 description 1
- 238000003759 clinical diagnosis Methods 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000003193 general anesthetic agent Substances 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 230000000770 proinflammatory effect Effects 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 238000012207 quantitative assay Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Measuring devices for evaluating the respiratory organs
- A61B5/082—Evaluation by breath analysis, e.g. determination of the chemical composition of exhaled breath
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Physiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Physics & Mathematics (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
The invention provides an expiration inflammation monitoring method. A subject does normal tidal breathing, a part of breathing gas in the process is collected, and the CO2 level is measured, and displayed on a display screen in real time; when it is detected that the CO2 level of the breathing gas reaches a preset range, the gas flow is led into a gas chamber; the operation is repeated within multi-time breathing cycles until the volume of the gas flow introduced into the gas chamber exceeds more than one time of the volume of the gas chamber; according to inflammation molecules needing to be measured, the flowing mode of the gas flow in an analysis gas channel and a concentration sensor of the passing gas are selected, and the gas molecule concentration in the gas chamber is measured; according to the recorded breathing frequency, the real concentration of the gas molecules in tidal breathing is calculated; according to the tidal volume of the subject, the equilibrium concentration of the gas molecules in pulmonary alveoli is calculated.
Description
Technical field
The present invention relates to characteristics of contaminated respiratory droplets gas monitoring arts.
Background technology
In characteristics of contaminated respiratory droplets gas, the measurement of different kinds of molecules concentration can diagnose patient disease by assist physician, monitoring disease states and observation therapeutic effect etc., exhaled NO and CO(eNO and eCO) can be used as the research that marker of inflammation is worth Intensive Care Therapy, this produces because endogenous gas signaling molecule NO and CO is decomposed by cortex cell arginine deaminizating and haemachrome respectively, infect, irritated, the pro-inflammatory cytokines such as wound all cause NO and CO concentration significantly to rise by increasing the expression of inductivity NO synzyme (iNOS) and Heme oxygenase (HO1), and by expired air analysis quantitative assay.And temporary transient not technology can be implemented in serious symptom, performs the operation and carry out in the process of Respiratory Care, Simultaneous Determination is carried out to the concentration of exhaled NO and CO.
Existing Respiratory Care technology comprises: partial pressure of carbon dioxide in endexpiratory gas (pETCO2) monitoring, anesthetic gases monitoring etc.The monitoring of partial pressure of carbon dioxide in endexpiratory gas (pETCO2) is described in patent CN201510038742, it passes through to measure CO2 dividing potential drop level curve in breathing and judges pulmonary ventilation and blood flow change, but does not carry out analytical test to inflammatory molecule NO and the CO in expiration; Patent CN201080049377 describes the monitor of anesthetic gases, this instrument is for monitoring the concentration of anesthetics in suction and breath, be used to guide the enforcement of anesthesia and improve anesthesia safety, also analytical test not carried out to inflammatory molecule NO and the CO in expiration.
And existing instrument of guarding airway inflammation has Aerocrine, MINO, VERO series (US20040082872) of Inc. and still fertile medical electronics receive a coulomb breath analysis instrument family.Wherein the product of Aerocrine, Inc. is mainly for detection of NO molecular concentration in expiration, and coulomb breath analyzing instrument of receiving can detect NO and CO molecular concentration in expiration respectively.And the expiration inflammatory molecule that two kinds of technology detect, all there is requirement to expiration state, eNO requires with the flow of 50ml/s at least exhalation 10s(child 6s), the eCO slowly expiration that to require to feel suffocated after 15s, to end of exhaling, cannot be used for breathing the expiration monitoring arts such as anesthesia Intensive Care Therapy.
Restrict this two instrument shorter for the cycle of technical factor mainly due to tidal breath in Respiratory Care field, when simple collection breath measures, have two problems: 1) respiratory frequency can affect the expired gas molecular concentration mensuration collected; 2) expired gas Middle molecule concentration can not molecular concentration in direct reaction steady state alveolar gas.
So, if a kind of expiration inflammation monitoring method or device can be provided, the breathing state of monitor patients while, gather the gas to the significant position of clinic diagnosis (air flue or alveolar), and analysis mensuration is carried out to some Gas Molecular Density wherein, this has great significance undoubtedly for expiration monitoring arts such as breathing anesthesia Intensive Care Therapies.
Summary of the invention
A technical problem to be solved by this invention is to provide a kind of expiration inflammation monitor device, the breathing state of monitor patients while, gather the gas to the significant position of clinic diagnosis (air flue or alveolar), and analysis mensuration is carried out to some Gas Molecular Density wherein.
Another technical problem to be solved by this invention is the breath molecular concentration that measures out and to the conversion between the significant physiology Gas Molecular Density of clinical diagnosis.
In order to solve above-mentioned two technical problems, the invention provides a kind of expiration inflammation monitoring method: when the normal tidal breath of experimenter, a part for the breathing gas in gatherer process, measures wherein CO2 level, and shows on a display screen in real time; Detecting that air-flow is directed into air chamber when reaching preset range by described expiration CO2 level; Aforesaid operations is repeated, until the airflow volume importing air chamber exceedes more than one times of gas chamber volume within repeatedly breathing cycle; According to the inflammatory molecule of required mensuration, select air-flow at the type of flow analyzing gas circuit and the gas concentration sensor flowed through, record this Gas Molecular Density in air chamber; According to recorded respiratory frequency, calculate the actual concentration of this gas molecule in moisture is exhaled; According to the tidal volume of experimenter, calculate the equilibrium concentration of this gas molecule in alveolar.
When said method is for gathering end-tidal or alveolar gas, before acquisition, experimenter's eupnea is allowed to practise several times, the gas meeting the preset range of expiration CO2 level is gathered after respiratory curve is steady, the preset range of described expiration CO2 level is determined by meeting two conditions below simultaneously, 1) in breathing for n-th time, expiration CO2 level >=end-tidal threshold value, 2) derivative of expiration CO2 level be on the occasion of.
This end-tidal threshold value is determined by condition below, threshold value=the N Yu Ji Zhi – B of the N time, the highest CO2 level+(1-a) * the N-1 time predicted value of the N time predicted value=a* the N-1 time, the highest CO2 Shui Ping – B wherein during the 1st predicted value=exercise, a, B are constant.
When said method is for gathering expiration front end or air flue gas, expiration CO2 level is greater than B and is less than end-tidal threshold value, and the derivative of expiration CO2 level be on the occasion of.
The Gas Molecular Density of direct test by the respiratory frequency of having demarcated in advance and concentration relationship curve amendment to the actual concentration of this gas molecule in moisture is exhaled.
When tidal breath, breath molecular concentration by reflecting steady state alveolar gas concentration formula after formula correction is: exhalation concentrations/steady state alveolar gas concentration=a*ln expired volume-b, a, b are constant.
In order to realize above-mentioned expiration inflammation monitoring method, present invention also offers a kind of expiration inflammation monitor device, be made up of control module (100), functional module (200) and display module (300), functional module at least comprises monitoring, sampling, analytic function, the three-way valve one (201) be connected with carbon dioxide module (202) front end, for switching air end and experimenter holds, carries out air zero point correction or Respiratory Care; The three-way valve two (203) be connected with carbon dioxide module (202) rear end is for switching air and air chamber (204), the expiration CO2 level recorded according to carbon dioxide module (202) and pre-conditioned, gas to be analyzed is imported air chamber, and ineligible gas drains into outside system; The three-way valve three (206) be connected with analysis pump (207) front end is for switching air chamber (204) and air chamber (204), filter one (205), the three-way valve four (208) be connected with analysis pump (207) rear end is for switching wetting balance device (209), gas concentration sensor one (210) and gas concentration sensor two (211), filter (212), and be connected with air chamber rear end, functional module entirety is in circulation pattern.
This display module (300) can be LED screen, TFT shields or is connected with computer, the information of display at least comprises breathes CO2 curve, real-time CO2 level, the concentration of respiratory frequency and at least one gas molecule, described display module (300) comprises sound and the light of abnormal curve alarm and prompting.
This gas concentration sensor can be these hydrogen sulfide gas sensor, CO gas sensor, hydrogen gas sensor, nitric oxide gas sensor.
This control module (100) comprises central processing module, power module, portable power source module and printer module.
As seen from the above technical solution provided by the invention, expiration inflammation monitoring method of the present invention and device, can guard the breathing state of patient easily, and various Gas Molecular Density measures in exhaling to it while monitoring, by the utilization of various algorithm, have modified the impact of respiratory frequency on measurement result, also can reflect the molecular concentration in steady state alveolar gas simultaneously.Technical scheme provided by the invention makes Respiratory Care, expiration sampling and expiration molecular assay be integrated in one, and improves the reliability of sampling and test.
Accompanying drawing explanation
A kind of expiration inflammation of Fig. 1 monitor device.
Expiration CO2 level curve and end-tidal pre-conditioned curve during Fig. 2 tidal breath.
Under the different respiratory frequency of Fig. 3, when testing concentration known CO, the test value accuracy before and after revising compares.
Detailed description of the invention
Below for utilizing expiration inflammation monitoring method of the present invention and device, in experimenter's tidal breath process, breathing CO2 level is guarded, wherein end-tidal CO gas is gathered and analyzes a detailed description of the invention of mensuration end-tidal CO concentration.
Experimenter uses the expiration inflammation monitor device as Fig. 1, tidal breath, CO2 module is entered with a part of gas in the air pump flow collection expired gas of 100ml/min, measure its CO2 water Ventilation, surveyed CO2 level is met pre-conditioned gas and import air chamber, outside ungratified discharge system.Fig. 2 is the pre-conditioned curve of its tidal breath expiration CO2 level curve and end-tidal, wherein the computational constant a of threshold value gets 0.2, B gets 3mmHg, and the respiratory frequency of this experimenter is 16bpm, the moisture breath (cumulative volume is the twice of gas chamber volume) in about 45 cycles of repeated acquisition.
The flow direction of gas when analyzing is air chamber 204, three-way valve 206, analysis pump 207, three-way valve 208, gas concentration sensor 211, filter 212, wherein gas concentration sensor 211 is electrochemical carbon monoxide sensor, and filter 212 is carbon monoxide filter.The tidal breath CO concentration that this experimenter directly tests is 1.2ppm, obtaining its true tidal breath CO concentration after revising according to recorded respiratory frequency 16bpm is 1.5ppm, again according to its tidal volume 450ml, conversing the equilibrium concentration of CO molecule in this experimenter's alveolar is 2.6ppm.Contrast with the method (feel suffocated after the dark air-breathing of experimenter 15s, then slow in gas exhalation, gathers last expired gas and carry out CO concentration analysis) detecting alveolar CO concentration in standard, both results are consistent, specifically compare and see the following form.
Fig. 3 is under different respiratory frequency, and when testing concentration known CO, the test value accuracy before and after revising compares, and as can be seen from the figure, respiratory frequency is faster, and it is larger that test value is on the low side, but by after correction, accuracy can within ± 10%.
Claims (10)
1. an expiration inflammation monitoring method, is characterized in that: the normal tidal breath of experimenter, and a part for the breathing gas in gatherer process, measures wherein CO2 level, and shows on a display screen in real time; Detecting that air-flow is directed into air chamber when reaching preset range by described expiration CO2 level; Aforesaid operations is repeated, until the airflow volume importing air chamber exceedes more than one times of gas chamber volume within repeatedly breathing cycle; According to the inflammatory molecule of required mensuration, select air-flow at the type of flow analyzing gas circuit and the gas concentration sensor flowed through, record this Gas Molecular Density in air chamber; According to recorded respiratory frequency, calculate the actual concentration of this gas molecule in moisture is exhaled; According to the tidal volume of experimenter, calculate the equilibrium concentration of this gas molecule in alveolar.
2. expiration inflammation monitoring method as claimed in claim 1, it is characterized in that: during for gathering end-tidal or alveolar gas, before acquisition, experimenter's eupnea is allowed to practise several times, until respiratory curve steadily after gather the gas meeting the preset range of expiration CO2 level, the preset range of described expiration CO2 level is determined by meeting two conditions below simultaneously, 1) in n-th breathing, expiration CO2 level >=end-tidal threshold value, 2) derivative of expiration CO2 level be on the occasion of.
3. expiration inflammation monitoring method as claimed in claim 2, it is characterized in that: end-tidal threshold value is determined by condition below, threshold value=the N Yu Ji Zhi – B of the N time, the highest CO2 level+(1-a) * the N-1 time predicted value of the N time predicted value=a* the N-1 time, the highest CO2 Shui Ping – B wherein during the 1st predicted value=exercise, a, B are constant.
4. expiration inflammation monitoring method as claimed in claim 1, it is characterized in that: during for gathering expiration front end or air flue gas, the preset range of described expiration CO2 level is: 1) B≤expiration CO2 horizontal < end-tidal threshold value, 2) derivative of expiration CO2 level be on the occasion of.
5. expiration inflammation monitoring method as claimed in claim 1, is characterized in that: the Gas Molecular Density of directly test by the respiratory frequency of having demarcated in advance and concentration relationship curve amendment to the actual concentration of this gas molecule in moisture is exhaled.
6. expiration inflammation monitoring method as claimed in claim 1, it is characterized in that: during tidal breath, breath molecular concentration by reflecting steady state alveolar gas concentration formula after formula correction is:
, a, b are constant.
7. an expiration inflammation monitor device, be made up of control module (100), functional module (200) and display module (300), it is characterized in that: functional module at least comprises monitoring, sampling, analytic function, the three-way valve one (201) be connected with carbon dioxide module (202) front end, for switching air end and experimenter holds, carries out air zero point correction or Respiratory Care; The three-way valve two (203) be connected with carbon dioxide module (202) rear end is for switching air and air chamber (204), the expiration CO2 level recorded according to carbon dioxide module (202) and pre-conditioned, gas to be analyzed is imported air chamber, and ineligible gas drains into outside system; The three-way valve three (206) be connected with analysis pump (207) front end is for switching air chamber (204) and air chamber (204), filter one (205), the three-way valve four (208) be connected with analysis pump (207) rear end is for switching wetting balance device (209), gas concentration sensor one (210) and gas concentration sensor two (211), filter (212), and be connected with air chamber rear end, functional module entirety is in circulation pattern.
8. expiration inflammation monitor device as claimed in claim 7, it is characterized in that: described display module (300) can be LED screen, TFT shields or is connected with computer, the information of display at least comprises breathes CO2 curve, real-time CO2 level, the concentration of respiratory frequency and at least one gas molecule, described display module (300) comprises sound and the light of abnormal conditions alarm and prompting.
9. expiration inflammation monitor device as claimed in claim 7, is characterized in that: described gas concentration sensor can be these hydrogen sulfide gas sensor, CO gas sensor, hydrogen gas sensor, nitric oxide gas sensor.
10. expiration inflammation monitor device as claimed in claim 7, is characterized in that: described control module (100) comprises central processing module, power module, portable power source module and printer module.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510881093.8A CN105496412B (en) | 2015-12-04 | 2015-12-04 | A kind of expiration inflammation monitoring method and device |
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| CN201510881093.8A CN105496412B (en) | 2015-12-04 | 2015-12-04 | A kind of expiration inflammation monitoring method and device |
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| CN105496412A true CN105496412A (en) | 2016-04-20 |
| CN105496412B CN105496412B (en) | 2019-04-19 |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106770738A (en) * | 2016-12-03 | 2017-05-31 | 浙江大学 | The expiratory air multi-analyte immunoassay instrument and detection method of a kind of gas concentration lwevel amendment |
| CN110441351A (en) * | 2019-07-15 | 2019-11-12 | 河北雄安绿研检验认证有限公司 | A kind of expiratory air VOCs detection device and application for the continuous self-appraisal of human health |
| CN111407280A (en) * | 2020-03-10 | 2020-07-14 | 山东大学 | End-tidal CO of noninvasive ventilator2Monitoring device and method |
| CN112782371A (en) * | 2021-01-29 | 2021-05-11 | 惠雨恩科技(深圳)有限公司 | Gas concentration detection device |
| CN113069102A (en) * | 2020-01-06 | 2021-07-06 | 深圳市先亚生物科技有限公司 | Breath collection system and method |
| CN113777244A (en) * | 2021-09-27 | 2021-12-10 | 惠雨恩科技(深圳)有限公司 | Alveolar gas concentration detection device and method for separating air passage |
| CN114814103A (en) * | 2022-04-28 | 2022-07-29 | 青岛华仁医疗用品有限公司 | Off-line exhaled gas nitric oxide detection device |
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| CN106770738A (en) * | 2016-12-03 | 2017-05-31 | 浙江大学 | The expiratory air multi-analyte immunoassay instrument and detection method of a kind of gas concentration lwevel amendment |
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| CN110441351A (en) * | 2019-07-15 | 2019-11-12 | 河北雄安绿研检验认证有限公司 | A kind of expiratory air VOCs detection device and application for the continuous self-appraisal of human health |
| CN113069102A (en) * | 2020-01-06 | 2021-07-06 | 深圳市先亚生物科技有限公司 | Breath collection system and method |
| CN111407280A (en) * | 2020-03-10 | 2020-07-14 | 山东大学 | End-tidal CO of noninvasive ventilator2Monitoring device and method |
| CN112782371A (en) * | 2021-01-29 | 2021-05-11 | 惠雨恩科技(深圳)有限公司 | Gas concentration detection device |
| CN113777244A (en) * | 2021-09-27 | 2021-12-10 | 惠雨恩科技(深圳)有限公司 | Alveolar gas concentration detection device and method for separating air passage |
| WO2023046169A1 (en) * | 2021-09-27 | 2023-03-30 | 惠雨恩科技(深圳)有限公司 | Alveolar gas concentration measurement apparatus and method for separated airway |
| CN114814103A (en) * | 2022-04-28 | 2022-07-29 | 青岛华仁医疗用品有限公司 | Off-line exhaled gas nitric oxide detection device |
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