CN105435116A - 用于治疗由血热引起的青春痘的药物 - Google Patents

用于治疗由血热引起的青春痘的药物 Download PDF

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CN105435116A
CN105435116A CN201510996273.0A CN201510996273A CN105435116A CN 105435116 A CN105435116 A CN 105435116A CN 201510996273 A CN201510996273 A CN 201510996273A CN 105435116 A CN105435116 A CN 105435116A
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陈雯雯
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Abstract

本发明公开了一种用于治疗由血热引起的青春痘的药物，主要由下述重量份配比的原料制成：金银花12-18份，黄芩12-18份，赤芍12-18份，丹皮12-18份，白芷12-18份，桃仁12-18份，莪术12-18份，黄连10-15份，桑白皮10-15份，白鲜皮10-15份，苍术10-15份，川芎10-15份，薄荷10-15份，生地18-22份，紫花地丁18-22份，刺蒺藜8-12份，茯苓15-20份。本发明用于治疗由血热引起的青春痘的药物，选取17种天然中药科学配伍，配方简单，各原料药协同作用起到清热解毒，凉血散瘀的效果，见效快，标本兼治，无毒副作用，而且其制备方法简单、服用方便，成本低。有效率达到95％以上。

Description

用于治疗由血热引起的青春痘的药物
技术领域
本发明涉及中药，具体是一种用于治疗由血热引起的青春痘的药物。
背景技术
青春痘，也叫痤疮、粉刺、暗疮，是皮肤科常见病，多发病。主要好发于青少年，在青春期男性有95％，女性有85％患过不同程度的痤疮，所以大家称其为“青春痘”是很贴切的。对青少年的心理和社交影响很大，但青春期后往往能自然减轻或痊愈。青春痘是一种发生于毛囊皮脂腺的慢性皮肤病，多发于头面部，颈部，前胸后背等皮脂腺丰富的部位。痤疮的发生主要与皮脂分泌过多、毛囊皮脂腺导管堵塞、细菌感染和炎症反应等因素密切相关。进入青春期后人体内雄激素特别是睾酮的水平迅速升高，促进皮脂腺发育并产生大量皮脂。同时毛囊皮脂腺导管的角化异常造成导管堵塞，皮脂排出障碍，形成角质栓即微粉刺。毛囊中多种微生物尤其是痤疮丙酸杆菌大量繁殖，痤疮丙酸杆菌产生的脂酶分解皮脂生成游离脂肪酸，同时趋化炎症细胞和介质，最终诱导并加重炎症反应。
皮损好发于面部及上胸背部。痤疮的非炎症性皮损表现为开放性和闭合性粉刺。闭合性粉刺(又称白头)的典型皮损是约1毫米大小的肤色丘疹，无明显毛囊开口。开放性粉刺(又称黑头)表现为圆顶状丘疹伴显著扩张的毛囊开口。粉刺进一步发展会演变成各种炎症性皮损，表现为炎性丘疹、脓疱、结节和囊肿。炎性丘疹呈红色，直径1～5毫米不等；脓疱大小一致，其中充满了白色脓液；结节直径大于5毫米，触之有硬结和疼痛感；囊肿的位置更深，充满了脓液和血液的混合物。这些皮损还可融合形成大的炎性斑块和窦道等。炎症性皮损消退后常常遗留色素沉着、持久性红斑、凹陷性或肥厚性瘢痕。痤疮消退后可留有暂时性色素斑，或小的坑凹状疤痕。
由血热引起的青春痘多由情志内伤，气分郁滞，日久化热，热伏营血所致。其症颜面丘疹以口鼻及两眉间为多,面部潮热明显，妇女尚有月经前后丘疹增多，舌红，脉细数等。
现在多以西药治疗为主，但是效果较慢，其副作用大，会引起其他疾病。而目前的一些中药的治疗效率也不甚理想，且疗效不显著。
发明内容
本发明的目的是提供一种疗效好、疗程短、成本低、无毒副作用的治疗由血热引起的青春痘的药物。
实现本发明目的的技术方案是：
一种用于治疗由血热引起的青春痘的药物，主要由下述重量份配比的原料制成：
金银花12-18份，黄芩12-18份，赤芍12-18份，丹皮12-18份，白芷12-18份，桃仁12-18份，莪术12-18份，黄连10-15份，桑白皮10-15份，白鲜皮10-15份，苍术10-15份，川芎10-15份，薄荷10-15份，生地18-22份，紫花地丁18-22份，刺蒺藜8-12份，茯苓15-20份。
上述用于治疗由血热引起的青春痘的药物，各原料的最佳重量份配比为：
金银花15份，黄芩15份，赤芍15份，丹皮15份，白芷15份，桃仁15份，莪术15份，黄连12份，桑白皮12份，白鲜皮12份，苍术12份，川芎12份，薄荷12份，生地20份，紫花地丁20份，刺蒺藜10份，茯苓18份。
所述的原料药材在中药店及市场有售。
本发明药物的制备方法如下：按重量配比称取各原料药，加入混合置于容器中，再加原料量重量10-20倍的水煎煮3次，每次煎煮30-40min，合并煎煮液，过滤去渣，滤液浓缩至50-60℃下相对密度为1.20-1.30的浸膏，加入辅料，制成相应的剂型，即得。
本发明中，各原料药的药理、功效如下：
金银花：既能宣散风热，还善清解血毒，用于各种热性病，如身热、发疹、发斑、热毒疮痈、咽喉肿痛等症。
黄芩：有清热燥湿、泻火解毒、止血、安胎等功效。主治温热病、上呼吸道感染、肺热咳嗽、湿热黄胆、肺炎、痢疾、咳血、目赤、胎动不安、高血压、痈肿疖疮等症。
赤芍：清热凉血，散瘀止痛。用于热人营血，温毒发斑，吐血衄血，目赤肿痛，肝郁胁痛，经闭痛经，瘾瘕腹痛，跌扑损伤，痈肿疮疡。
丹皮：清热凉血；活血散瘀。温热病热入血分；发斑；吐衄；热泪盈眶病菌后期热伏阴分发热；阴虚骨蒸潮热；血滞经闭；痛经；痈肿疮毒；跌扑伤痛；风湿热痹。
白芷：解表散寒，祛风止痛，通鼻窍，燥湿止带，消肿排脓，祛风止痒。风寒感冒，头痛、牙痛、风湿痹痛，鼻渊，带下证，疮痈肿毒。
桃仁：具有活血祛瘀，润肠通便，止咳平喘的功效。用于经闭痛经，瘕瘕痞块，肺痈肠痈，跌扑损伤，肠燥便秘，咳嗽气喘。
莪术：破血行气，消积止痛。用于血瘀腹痛、肝脾肿大、心腹胀痛，积聚，妇女血瘀经闭，跌打损伤作痛饮食积滞。
黄连：清热燥湿，泻火解毒。湿热痞满，呕吐吞酸，泻痢，黄疸，高热神昏，心火亢盛，心烦不寐，心悸不宁，血热吐衄，目赤，牙痛，消渴，痈肿疗疮；外治湿疹，湿疮，耳道流脓。
桑白皮：泻肺平喘，利水消肿。用于肺热喘咳，水肿胀满，尿少，面目肌肤浮肿。
白鲜皮：清热燥湿，祛风解毒。湿热疮毒，黄水淋漓，湿疹，风疹，疥癣疮癞，风湿热痹。
苍术：燥湿健脾，祛风散寒，明目。用于湿阻中焦，脘腹胀满，泄泻，水肿，脚气痿蹙，风湿痹痛，风寒感冒，夜盲，眼目昏涩。
川芎：行气开郁，法风燥湿，活血止痛。治风冷头痛旋晕，胁痛腹疼，寒痹筋挛，经闭，难产，产后瘀阻块痛，痈疽疮疡。用于月经不调，经闭痛经，瘕腹痛，胸胁刺痛，跌扑肿痛，头痛，风湿痹痛。
薄荷：疏散风热，清利头目，利咽透疹，疏肝行气。外感风热，头痛，咽喉肿痛，食滞气胀，口疮，牙痛，疮疥，瘾疹，温病初起，风疹瘙痒，肝郁气滞，胸闷胁痛。
生地：具有清热凉血、益阴生津之功效。用于温热病热入营血，壮热神昏，口干舌绛。
紫花地丁：有清热解毒的功效。主治黄疸、痢疾、乳腺炎、目赤肿痛、咽炎；外敷治跌打损伤、痈肿、毒蛇咬伤。
刺蒺藜：散风，明目，下气，行血。治头痛，身痒，目赤肿翳，胸满，咳逆，症瘕，乳难，痈疽，瘰疬。平肝；解郁；祛风明目。
茯苓：利水渗湿，健脾，宁心。用于水肿尿少，痰饮眩悸，脾虚食少，便溏泄泻，心神不安，惊悸失眠。
本发明用于治疗由血热引起的青春痘的药物，选取17种天然中药科学配伍，配方简单，各原料药协同作用起到清热解毒，凉血散瘀的效果，见效快，标本兼治，无毒副作用，而且其制备方法简单、服用方便，成本低。
具体实施方式
下面结合实施例对本发明内容作进一步的说明，但不是对本发明的限定。
实施例1
一种用于治疗由血热引起的青春痘的药物，主要由下述重量份配比的原料制成：
金银花12kg，黄芩12kg，赤芍12kg，丹皮12kg，白芷12kg，桃仁1212kg，莪术1212kg，黄连10kg，桑白皮10kg，白鲜皮10kg，苍术10kg，川芎10kg，薄荷10kg，生地18kg，紫花地丁18kg，刺蒺藜8kg，茯苓15kg。
制备方法如下：按上述称取各原料药混合置于容器中，再加原料量重量10倍的水煎煮3次，每次煎煮30min，合并煎煮液，过滤去渣，滤液浓缩至50℃下相对密度为1.20的浸膏，加入辅料，制成片剂，每片0.1g。
实施例2
一种用于治疗由血热引起的青春痘的药物，主要由下述重量份配比的原料制成：
金银花15kg，黄芩15kg，赤芍15kg，丹皮15kg，白芷15kg，桃仁15kg，莪术15kg，黄连12kg，桑白皮12kg，白鲜皮12kg，苍术12kg，川芎12kg，薄荷12kg，生地20kg，紫花地丁20kg，刺蒺藜10kg，茯苓18kg。
制备方法如下：按上述称取各原料药混合置于容器中，再加原料量重量15倍的水煎煮3次，每次煎煮34min，合并煎煮液，过滤去渣，滤液浓缩至53℃下相对密度为1.20的浸膏，加入辅料，制成片剂，每片0.2g。
实施例3
一种用于治疗由血热引起的青春痘的药物，主要由下述重量份配比的原料制成：
金银花18kg，黄芩18kg，赤芍18kg，丹皮18kg，白芷18kg，桃仁18kg，莪术18kg，黄连15kg，桑白皮15kg，白鲜皮15kg，苍术15kg，川芎15kg，薄荷15kg，生地22kg，紫花地丁22kg，刺蒺藜12kg，茯苓20kg。
制备方法如下：按上述称取各原料药混合置于容器中，再加原料量重量18倍的水煎煮3次，每次煎煮37min，合并煎煮液，过滤去渣，滤液浓缩至57℃下相对密度为1.30的浸膏，加入辅料，制成丸剂，每粒0.4g。
实施例4
一种用于治疗由血热引起的青春痘的药物，主要由下述重量份配比的原料制成：
金银花18kg，黄芩18kg，赤芍18kg，丹皮18kg，白芷18kg，桃仁18kg，莪术18kg，黄连15kg，桑白皮15kg，白鲜皮15kg，苍术15kg，川芎15kg，薄荷15kg，生地22kg，紫花地丁22kg，刺蒺藜12kg，茯苓20kg。
制备方法如下：按上述称取各原料药混合置于容器中，再加原料量重量20倍的水煎煮3次，每次煎煮40min，合并煎煮液，过滤去渣，滤液浓缩至60℃下相对密度为1.30的浸膏，加入辅料，制成丸剂，每粒0.5g。
为了进一步证明本发明中药的临床疗效，选择收治患者中的200例，对本发明药物的疗效进行临床观察。年龄15-35岁，随机分为4组，每组为50例，分别为实验组1-4组。
实验组1-4组分别服用实施例1-4的药物，每日2次，每次内服3片/粒，10天为一个疗程，连续服用2-3个疗程，视病情轻重加减疗程。其中显效185例，有效182例，治愈190例，无效10例，治愈率91％，有效率95％。

Claims (3)

1.一种用于治疗由血热引起的青春痘的药物，其特征是：主要由下述重量份配比的原料制成：
金银花12-18份，黄芩12-18份，赤芍12-18份，丹皮12-18份，白芷12-18份，桃仁12-18份，莪术12-18份，黄连10-15份，桑白皮10-15份，白鲜皮10-15份，苍术10-15份，川芎10-15份，薄荷10-15份，生地18-22份，紫花地丁18-22份，刺蒺藜8-12份，茯苓15-20份。
2.根据权利要求1所述的用于治疗由血热引起的青春痘的药物，其特征是：各原料的最佳重量份配比为：
金银花15份，黄芩15份，赤芍15份，丹皮15份，白芷15份，桃仁15份，莪术15份，黄连12份，桑白皮12份，白鲜皮12份，苍术12份，川芎12份，薄荷12份，生地20份，紫花地丁20份，刺蒺藜10份，茯苓18份。
3.根据权利要求1所述的用于治疗由热毒引起的青春痘的药物，其特征是：
制备方法如下：按重量配比称取各原料药，加入混合置于容器中，再加原料量重量10-20倍的水煎煮3次，每次煎煮30-40min，合并煎煮液，过滤去渣，滤液浓缩至50-60℃下相对密度为1.20-1.30的浸膏，加入辅料，制成相应的剂型，即得。
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