CN105434995A - Traditional Chinese medicine gel paste patch for treating lung cold cough and preparation and using method thereof - Google Patents

Traditional Chinese medicine gel paste patch for treating lung cold cough and preparation and using method thereof Download PDF

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CN105434995A
CN105434995A CN201510899968.7A CN201510899968A CN105434995A CN 105434995 A CN105434995 A CN 105434995A CN 201510899968 A CN201510899968 A CN 201510899968A CN 105434995 A CN105434995 A CN 105434995A
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parts
traditional chinese
chinese medicine
gel
radix
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廖冲
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/54Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
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    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284Atractylodes
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/34Campanulaceae (Bellflower family)
    • A61K36/346Platycodon
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/36Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481Astragalus (milkvetch)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/535Perilla (beefsteak plant)
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/538Schizonepeta
    • AHUMAN NECESSITIES
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    • A61K36/185Magnoliopsida (dicotyledons)
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/752Citrus, e.g. lime, orange or lemon
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    • A61K36/88Liliopsida (monocotyledons)
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    • A61K36/8888Pinellia
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    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/894Dioscoreaceae (Yam family)
    • A61K36/8945Dioscorea, e.g. yam, Chinese yam or water yam
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    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8962Allium, e.g. garden onion, leek, garlic or chives
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/7023Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
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    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH

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Abstract

The invention discloses a traditional Chinese medicine gel paste patch for treating the lung cold cough and a preparation and using method thereof. The traditional Chinese medicine gel paste patch is prepared from, by weight, 12-18 parts of cassis twigs, 5-7 parts of purple perilla, 8-12 parts of schizonepeta, 8-12 parts of atractylodes, 8-12 parts of radix astragali, 5-7 parts of radix pseudostellariae, 5-7 parts of exocarpium citri grandis, 5-7 parts of rhizoma pinelliae preparata, 8-10 parts of platycodon grandiflorus, 8-12 parts of aster, 8-12 parts of Schisandra chinensis, 8-12 parts of Japanese ardisia herb, 8-12 parts of Chinese yam, 8-12 parts of roasted malt, 8-12 parts of roasted medicated leaven, 15-20 parts of garlic and 60-170 parts of gel matrixes. The gel paste patch is attached to the throat of the neck and the arch of the foot and is kept for 24-36 hours, a treatment course lasts for 5 days, and the traditional Chinese medicine gel paste patch is continuously used for 1-3 treatment courses.

Description

The Traditional Chinese medicine gel patch for the treatment of lung cold cough and preparation and application thereof
Technical field
The present invention relates to tcm field, particularly relate to a kind of Traditional Chinese medicine gel patch and preparation and application thereof for the treatment of lung cold cough.
Background technology
Doctor trained in Western medicine thinks that cough is a kind of protectiveness respiratory reflex action of human body.First cough action is quick very brief air-breathing, and diaphragm declines, and glottis is closed rapidly, and respiratory muscle and abdominal muscle rapid desufflation, make intrapulmonic pressure rise rapidly immediately; Then glottis throws open, lung inner high voltage jet-impingement and going out, and impact glottis crack and cough action and the special sound occur, respiratory tract endocrine or foreign body etc. are also discharged thereupon.Effectively can remove the secretions in respiratory tract by coughre flex or enter the foreign body of air flue.But cough also has disadvantageous one side, violent cough can cause respiratory tract hemorrhage, and as a long time, frequently, violent cough affects work, has a rest, even causes laryngalgia, and hoarseness and breathing myalgia, then belong to pathological phenomenon.Western medical treatment cough generally adopts transfusion, have an injection, have Western medicine, and the methods such as maintenance of recuperating is recuperated.General medicine takes costly, but curative effect is undesirable, is mostly to control table and do not effect a permanent cure, and often restores to the original state from patient after medicine.
The traditional Chinese medical science thinks that cough is because exopathogen violates lung, or internal organs internal injury, involves caused by the lung.The traditional Chinese medical science is divided by internal organs QI and blood, and cough has lung cold cough, the deficiency of the lung is coughed, pulmonary cough, cough referring to the heart, cough due to disorder of the liver, cough due to the spleen disease etc. are multiple, and wherein, lung cold cough is more common in the winter time, but, long for the course for the treatment of to the treatment ubiquity of lung cold cough at present, the defects such as effect is undesirable.Also there is no the gel patch effectively can treating lung cold cough at present.
Summary of the invention
An object of the present invention is to solve at least the problems referred to above and/or defect, and the advantage will illustrated at least is below provided.
Another object of the present invention is to provide a kind of Traditional Chinese medicine gel patch for the treatment of lung cold cough, effectively can treat lung cold cough, and easy to use, and long action time, has no side effect.
A further object of the invention is to provide a kind of preparation method for the treatment of the Traditional Chinese medicine gel patch of lung cold cough.
Other objects with some for achieving the above object, the present invention adopts following technical scheme:
Treat a Traditional Chinese medicine gel patch for lung cold cough, comprise the component of following weight portion:
Ramulus Cinnamomi 12-18, Folium Perillae 5-7, Herba Schizonepetae 8-12, Rhizoma Atractylodis Macrocephalae 8-12, Radix Astragali 8-12, Radix Pseudostellariae 5-7, Exocarpium Citri Grandis 5-7, Rhizoma Pinelliae 5-7, Radix Platycodonis 8-10, Radix Asteris 8-12, Fructus Schisandrae Chinensis 8-12, Herba Ardisiae Japonicae 8-12, Rhizoma Dioscoreae 8-12, Fructus Hordei Germinatus (parched) 8-12, Massa Medicata Fermentata preparata 8-12, Bulbus Allii 15-20 and gel-type vehicle 60-170.
Preferably, in the Traditional Chinese medicine gel patch of described treatment lung cold cough, the component of following weight portion is comprised:
Ramulus Cinnamomi 15, Folium Perillae 6, Herba Schizonepetae 10, the Rhizoma Atractylodis Macrocephalae 10, the Radix Astragali 10, Radix Pseudostellariae 6, Exocarpium Citri Grandis 6, Rhizoma Pinelliae 6, Radix Platycodonis 9, Radix Asteris 10, Fructus Schisandrae Chinensis 9, Herba Ardisiae Japonicae 10, Rhizoma Dioscoreae 10, Fructus Hordei Germinatus (parched) 10, Massa Medicata Fermentata preparata 10, Bulbus Allii 18 and gel-type vehicle 100.
Preferably, in the Traditional Chinese medicine gel patch of described treatment lung cold cough, described gel-type vehicle comprises following parts by weight of component: gelatin 20-40, silica 1 0-30, sodium polyacrylate 10-30, polyvidone 10-30, sodium carboxymethyl cellulose 6-16, carbomer 2-6, ethyl hydroxybenzoate 0.2-1 and glycerol 300-500.
Treat a preparation method for the Traditional Chinese medicine gel patch of lung cold cough, comprise the following steps:
Step one, Ramulus Cinnamomi, Folium Perillae, Herba Schizonepetae, the Rhizoma Atractylodis Macrocephalae, the Radix Astragali, Radix Pseudostellariae, Exocarpium Citri Grandis, Rhizoma Pinelliae, Radix Platycodonis, Radix Asteris, Fructus Schisandrae Chinensis, Herba Ardisiae Japonicae, Rhizoma Dioscoreae, Fructus Hordei Germinatus (parched), Massa Medicata Fermentata preparata and Bulbus Allii are dried, pulverizing is ground to more than 120 orders, obtain medicated powder, by the 70-80% ethanol mixed extraction of gained medicated powder and 6-8 times of volume, obtain extracting solution;
Step 2, extracting solution heating is brewed into thick, obtains thick paste;
Step 3, gelatin added 8-12 times of water dilution, then with thick paste and silicon dioxide mix and blend, obtain admixing medical solutions;
Step 4, by Borneolum Syntheticum, sodium polyacrylate, polyvidone, sodium carboxymethyl cellulose, carbomer, ethyl hydroxybenzoate, glycerol mixing after and gained admixing medical solutions Hybrid Heating, obtain drug gel, be coated with drug gel and obtain described gel patch.
Preferably, in the preparation method of the Traditional Chinese medicine gel patch of described treatment lung cold cough, in step 4, described drug gel coating thickness is 2-3mm, coating bonnet lining, dry in the air 20-30 hour under the environment of temperature 25 ± 2 DEG C, relative humidity 50 ± 5%, obtains described gel patch.
Treat a using method for the Traditional Chinese medicine gel patch of lung cold cough, get described gel cream note and be affixed on cervical region throat place and arch of the foot place respectively, often paste and keep 24-36 hour, every 5 days courses for the treatment of, paste 1-3 the course for the treatment of continuously.
The present invention at least comprises following beneficial effect: first, and the present invention utilizes the traditional Chinese medical science five elements and dialectical theory, thinks that the cause of disease of lung cold cough is relevant with people's diet, because of the deficiency of the lung usually, eating cold drink, so that cold-evil's impairing the lung, sends out as cough.Treatment should expelling wind and cold pathogens, open lung qi dispersing gas, then gas is clear along expectorant, and coughs from stopping also.In addition, the present invention is prepared as instant granular by the Chinese medicine composition effectively can treating lung cold cough by operations such as lixiviates, drinks conveniently, can effectively prevent and treat lung cold cough.
Secondly, the present invention, can the long action time of prolong drug by the Chinese medicine composition for the treatment of lung cold cough being prepared into the form of gel patch, makes effective ingredient directly infiltrate through human body by pore, easy to use.
Part is embodied by explanation below by other advantage of the present invention, target and feature, part also will by research and practice of the present invention by those skilled in the art is understood.
Detailed description of the invention
Below the present invention is elaborated, can implement according to this after consulting this description to make those of ordinary skill in the art.
Treat a Traditional Chinese medicine gel patch for lung cold cough, comprise the component of following weight portion: Ramulus Cinnamomi 12-18, Folium Perillae 5-7, Herba Schizonepetae 8-12, Rhizoma Atractylodis Macrocephalae 8-12, Radix Astragali 8-12, Radix Pseudostellariae 5-7, Exocarpium Citri Grandis 5-7, Rhizoma Pinelliae 5-7, Radix Platycodonis 8-10, Radix Asteris 8-12, Fructus Schisandrae Chinensis 8-12, Herba Ardisiae Japonicae 8-12, Rhizoma Dioscoreae 8-12, Fructus Hordei Germinatus (parched) 8-12, Massa Medicata Fermentata preparata 8-12, Bulbus Allii 15-20 and gel-type vehicle 60-170.
The present invention utilizes the traditional Chinese medical science five elements and dialectical theory, thinks that the cause of disease of lung cold cough is relevant with people's diet, because of the deficiency of the lung usually, eating cold drink, so that cold-evil's impairing the lung, sends out as cough.Treatment should expelling wind and cold pathogens, open lung qi dispersing gas, then gas is clear along expectorant, and coughs from stopping also.
Ramulus Cinnamomi, pungent loose temperature is led to, feasible flesh table and play the effect of inducing sweat, dispersing wind and cold; Folium Perillae, disperses exterior cold, opens lung qi dispersing gas; Herba Schizonepetae, expelling wind and cold pathogens, throat; The Rhizoma Atractylodis Macrocephalae, dehumidifying QI invigorating, expectorant is relieved oedema or abdominal distension through diuresis or purgation; The Radix Astragali, the sweet tepor of property, benefit defends consolidating superficial resistance, tonifying the lung gas; Radix Pseudostellariae, mends strengthening spleen and lung, reduces phlegm and quench the thirst; Exocarpium Citri Grandis, drying dampness to eliminate phlegm; Rhizoma Pinelliae, the property of tool warm-dryness syndrome, can dampness and reducing phlegm, and tool antitussive action; Radix Platycodonis, pungent loose hardship is let out, and opens lung qi dispersing gas, and sharp septum pectorale throat, eliminate the phlegm; Radix Asteris, gentle hardship is let out, preventing phlegm from forming and stopping coughing; Fructus Schisandrae Chinensis, sour in the mouth tepor, nourishing kidney of astringing the lung, relieve coughing Dingchuan; Herba Ardisiae Japonicae, bitterness is put down, eliminating phlegm and stopping cough; Rhizoma Dioscoreae, strengthening the spleen and stomach, tonifying the lung gas, reinforcing the mother-organ for treating deficiency of the son-organ; Fructus Hordei Germinatus (parched), Massa Medicata Fermentata preparata, invigorating the spleen and benefiting QI.Bulbus Allii, Xin Gan, heat, exorcising, virus killing gas.
In the Traditional Chinese medicine gel patch of described treatment lung cold cough, comprise the component of following weight portion: Ramulus Cinnamomi 15, Folium Perillae 6, Herba Schizonepetae 10, the Rhizoma Atractylodis Macrocephalae 10, the Radix Astragali 10, Radix Pseudostellariae 6, Exocarpium Citri Grandis 6, Rhizoma Pinelliae 6, Radix Platycodonis 9, Radix Asteris 10, Fructus Schisandrae Chinensis 9, Herba Ardisiae Japonicae 10, Rhizoma Dioscoreae 10, Fructus Hordei Germinatus (parched) 10, Massa Medicata Fermentata preparata 10, Bulbus Allii 18 and gel-type vehicle 100.
In the Traditional Chinese medicine gel patch of described treatment lung cold cough, described gel-type vehicle comprises following parts by weight of component: gelatin 20-40, silica 1 0-30, sodium polyacrylate 10-30, polyvidone 10-30, sodium carboxymethyl cellulose 6-16, carbomer 2-6, ethyl hydroxybenzoate 0.2-1 and glycerol 300-500.
A kind of preparation method for the treatment of the Traditional Chinese medicine gel patch of lung cold cough, comprise the following steps: step one, Ramulus Cinnamomi, Folium Perillae, Herba Schizonepetae, the Rhizoma Atractylodis Macrocephalae, the Radix Astragali, Radix Pseudostellariae, Exocarpium Citri Grandis, Rhizoma Pinelliae, Radix Platycodonis, Radix Asteris, Fructus Schisandrae Chinensis, Herba Ardisiae Japonicae, Rhizoma Dioscoreae, Fructus Hordei Germinatus (parched), Massa Medicata Fermentata preparata and Bulbus Allii are dried, pulverizing is ground to more than 120 orders, obtain medicated powder, by the 70-80% ethanol mixed extraction of gained medicated powder and 6-8 times of volume, obtain extracting solution; Step 2, extracting solution heating is brewed into thick, obtains thick paste; Step 3, gelatin added 8-12 times of water dilution, then with thick paste and silicon dioxide mix and blend, obtain admixing medical solutions; Step 4, by Borneolum Syntheticum, sodium polyacrylate, polyvidone, sodium carboxymethyl cellulose, carbomer, ethyl hydroxybenzoate, glycerol mixing after and gained admixing medical solutions Hybrid Heating, obtain drug gel, be coated with drug gel and obtain described gel patch.
In the preparation method of the Traditional Chinese medicine gel patch of described treatment lung cold cough, in step 4, described drug gel coating thickness is 2-3mm, coating bonnet lining, dry in the air 20-30 hour under the environment of temperature 25 ± 2 DEG C, relative humidity 50 ± 5%, obtains described gel patch.
Treat a using method for the Traditional Chinese medicine gel patch of lung cold cough, get described gel cream note and be affixed on cervical region throat place and arch of the foot place respectively, often paste and keep 24-36 hour, every 5 days courses for the treatment of, paste 1-3 the course for the treatment of continuously.
Although embodiment of the present invention are open as above, but it is not restricted to listed in description and embodiment utilization, it can be applied to various applicable the field of the invention completely, for those skilled in the art, can easily realize other amendment, therefore do not deviating under the general concept that claim and equivalency range limit, the present invention is not limited to specific details.

Claims (6)

1. treat a Traditional Chinese medicine gel patch for lung cold cough, it is characterized in that, comprise the component of following weight portion:
Ramulus Cinnamomi 12-18, Folium Perillae 5-7, Herba Schizonepetae 8-12, Rhizoma Atractylodis Macrocephalae 8-12, Radix Astragali 8-12, Radix Pseudostellariae 5-7, Exocarpium Citri Grandis 5-7, Rhizoma Pinelliae 5-7, Radix Platycodonis 8-10, Radix Asteris 8-12, Fructus Schisandrae Chinensis 8-12, Herba Ardisiae Japonicae 8-12, Rhizoma Dioscoreae 8-12, Fructus Hordei Germinatus (parched) 8-12, Massa Medicata Fermentata preparata 8-12, Bulbus Allii 15-20 and gel-type vehicle 60-170.
2. the Traditional Chinese medicine gel patch for the treatment of lung cold cough as claimed in claim 1, is characterized in that, comprise the component of following weight portion:
Ramulus Cinnamomi 15, Folium Perillae 6, Herba Schizonepetae 10, the Rhizoma Atractylodis Macrocephalae 10, the Radix Astragali 10, Radix Pseudostellariae 6, Exocarpium Citri Grandis 6, Rhizoma Pinelliae 6, Radix Platycodonis 9, Radix Asteris 10, Fructus Schisandrae Chinensis 9, Herba Ardisiae Japonicae 10, Rhizoma Dioscoreae 10, Fructus Hordei Germinatus (parched) 10, Massa Medicata Fermentata preparata 10, Bulbus Allii 18 and gel-type vehicle 100.
3. the Traditional Chinese medicine gel patch for the treatment of lung cold cough as claimed in claim 1, it is characterized in that, described gel-type vehicle comprises following parts by weight of component: gelatin 20-40, silica 1 0-30, sodium polyacrylate 10-30, polyvidone 10-30, sodium carboxymethyl cellulose 6-16, carbomer 2-6, ethyl hydroxybenzoate 0.2-1 and glycerol 300-500.
4. a preparation method for the Traditional Chinese medicine gel patch for the treatment of lung cold cough as claimed in claim 3, is characterized in that, comprise the following steps:
Step one, Ramulus Cinnamomi, Folium Perillae, Herba Schizonepetae, the Rhizoma Atractylodis Macrocephalae, the Radix Astragali, Radix Pseudostellariae, Exocarpium Citri Grandis, Rhizoma Pinelliae, Radix Platycodonis, Radix Asteris, Fructus Schisandrae Chinensis, Herba Ardisiae Japonicae, Rhizoma Dioscoreae, Fructus Hordei Germinatus (parched), Massa Medicata Fermentata preparata and Bulbus Allii are dried, pulverizing is ground to more than 120 orders, obtain medicated powder, by the 70-80% ethanol mixed extraction of gained medicated powder and 6-8 times of volume, obtain extracting solution;
Step 2, extracting solution heating is brewed into thick, obtains thick paste;
Step 3, gelatin added 8-12 times of water dilution, then with thick paste and silicon dioxide mix and blend, obtain admixing medical solutions;
Step 4, by Borneolum Syntheticum, sodium polyacrylate, polyvidone, sodium carboxymethyl cellulose, carbomer, ethyl hydroxybenzoate, glycerol mixing after and gained admixing medical solutions Hybrid Heating, obtain drug gel, be coated with drug gel and obtain described gel patch.
5. the preparation method of the Traditional Chinese medicine gel patch for the treatment of lung cold cough as claimed in claim 4, it is characterized in that, in step 4, described drug gel coating thickness is 2-3mm, coating bonnet lining, dry in the air 20-30 hour under the environment of temperature 25 ± 2 DEG C, relative humidity 50 ± 5%, obtains described gel patch.
6. the using method of the Traditional Chinese medicine gel patch of the treatment lung cold cough as described in claim 1 or 4, it is characterized in that, get described gel cream note and be affixed on cervical region throat place and arch of the foot place respectively, often paste and keep 24-36 hour, every 5 days courses for the treatment of, paste 1-3 the course for the treatment of continuously.
CN201510899968.7A 2015-12-08 2015-12-08 Traditional Chinese medicine gel paste patch for treating lung cold cough and preparation and using method thereof Pending CN105434995A (en)

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