CN105412865A - Gongyankang granules and preparation method thereof - Google Patents
Gongyankang granules and preparation method thereof Download PDFInfo
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- CN105412865A CN105412865A CN201510863229.2A CN201510863229A CN105412865A CN 105412865 A CN105412865 A CN 105412865A CN 201510863229 A CN201510863229 A CN 201510863229A CN 105412865 A CN105412865 A CN 105412865A
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- 239000008187 granular material Substances 0.000 title claims abstract description 12
- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- 239000000843 powder Substances 0.000 claims abstract description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 16
- 235000021419 vinegar Nutrition 0.000 claims abstract description 10
- 239000000052 vinegar Substances 0.000 claims abstract description 10
- 229920001353 Dextrin Polymers 0.000 claims abstract description 9
- 239000004375 Dextrin Substances 0.000 claims abstract description 9
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims abstract description 9
- 229920001214 Polysorbate 60 Polymers 0.000 claims abstract description 9
- 235000019425 dextrin Nutrition 0.000 claims abstract description 9
- GNPVGFCGXDBREM-UHFFFAOYSA-N germanium atom Chemical compound [Ge] GNPVGFCGXDBREM-UHFFFAOYSA-N 0.000 claims abstract description 9
- 239000008101 lactose Substances 0.000 claims abstract description 9
- 150000003839 salts Chemical class 0.000 claims abstract description 8
- 208000029082 Pelvic Inflammatory Disease Diseases 0.000 claims abstract description 6
- 230000001684 chronic effect Effects 0.000 claims abstract description 6
- 239000002245 particle Substances 0.000 claims description 24
- 239000000284 extract Substances 0.000 claims description 21
- 241000195474 Sargassum Species 0.000 claims description 10
- 241000628997 Flos Species 0.000 claims description 9
- 238000001035 drying Methods 0.000 claims description 8
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 claims description 8
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 claims description 8
- 229940113124 polysorbate 60 Drugs 0.000 claims description 8
- 210000000582 semen Anatomy 0.000 claims description 8
- 239000007921 spray Substances 0.000 claims description 8
- 206010013786 Dry skin Diseases 0.000 claims description 7
- 229910052623 talc Inorganic materials 0.000 claims description 7
- 235000012222 talc Nutrition 0.000 claims description 7
- 239000000454 talc Substances 0.000 claims description 7
- 238000005550 wet granulation Methods 0.000 claims description 7
- 239000003814 drug Substances 0.000 claims description 6
- 230000000694 effects Effects 0.000 abstract description 8
- 241000382455 Angelica sinensis Species 0.000 abstract description 2
- 241000729196 Lycopus lucidus Species 0.000 abstract description 2
- 244000294611 Punica granatum Species 0.000 abstract description 2
- 235000014360 Punica granatum Nutrition 0.000 abstract description 2
- 238000002137 ultrasound extraction Methods 0.000 abstract 2
- 241001474374 Blennius Species 0.000 abstract 1
- 244000020518 Carthamus tinctorius Species 0.000 abstract 1
- 235000003255 Carthamus tinctorius Nutrition 0.000 abstract 1
- 241001233914 Chelidonium majus Species 0.000 abstract 1
- 208000007882 Gastritis Diseases 0.000 abstract 1
- 235000003805 Musa ABB Group Nutrition 0.000 abstract 1
- 240000008790 Musa x paradisiaca Species 0.000 abstract 1
- 206010033645 Pancreatitis Diseases 0.000 abstract 1
- 206010033647 Pancreatitis acute Diseases 0.000 abstract 1
- 235000015266 Plantago major Nutrition 0.000 abstract 1
- 244000273928 Zingiber officinale Species 0.000 abstract 1
- 235000006886 Zingiber officinale Nutrition 0.000 abstract 1
- 201000003229 acute pancreatitis Diseases 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 235000008397 ginger Nutrition 0.000 abstract 1
- 239000011858 nanopowder Substances 0.000 abstract 1
- 238000001694 spray drying Methods 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 description 5
- 235000013399 edible fruits Nutrition 0.000 description 4
- 239000012535 impurity Substances 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 241001078983 Tetradium ruticarpum Species 0.000 description 3
- YBMRDBCBODYGJE-UHFFFAOYSA-N germanium dioxide Chemical compound O=[Ge]=O YBMRDBCBODYGJE-UHFFFAOYSA-N 0.000 description 3
- 230000010354 integration Effects 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 241000961970 Plantago depressa Species 0.000 description 2
- 241000264279 Sargassum fusiforme Species 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 241001290610 Abildgaardia Species 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- 241000208327 Apocynaceae Species 0.000 description 1
- 241000202726 Bupleurum Species 0.000 description 1
- 235000008495 Chrysanthemum leucanthemum Nutrition 0.000 description 1
- 244000192528 Chrysanthemum parthenium Species 0.000 description 1
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 description 1
- 241000219991 Lythraceae Species 0.000 description 1
- 241000013557 Plantaginaceae Species 0.000 description 1
- 240000002505 Pogostemon cablin Species 0.000 description 1
- 235000011751 Pogostemon cablin Nutrition 0.000 description 1
- 241000331449 Vincetoxicum pycnostelma Species 0.000 description 1
- 235000013527 bean curd Nutrition 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000006837 decompression Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 235000008384 feverfew Nutrition 0.000 description 1
- 230000004345 fruit ripening Effects 0.000 description 1
- 229940119177 germanium dioxide Drugs 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 238000010025 steaming Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000003813 thin hair Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/02—Algae
- A61K36/03—Phaeophycota or phaeophyta (brown algae), e.g. Fucus
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/27—Asclepiadaceae (Milkweed family), e.g. hoya
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/68—Plantaginaceae (Plantain Family)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/754—Evodia
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The invention discloses gongyankang granules and a preparation method thereof. The preparation method is characterized in that 75 g of cablin potchouli herb, 120 g of pomegranate peel, 7.5 g of fructus evodiae, 90 g of radix angelica sinensis, 240 g of paniculate swallowwort roots, 95 g of rhizoma cyperi (processed with vinegar), 81 g of baked ginger, 80 g of hiraute shiny bugleweed herb, 78 g of carthamus tinctorius, 75 g of radix bupleuri, 95 g of seaweed and 110 g of plantain seeds (stir-fried with salt) are taken and smashed into coarse powder, the coarse powder is put into a circulated and ultrasonic extraction device, water, germanium powder and Tween 60 are added, ultrasonic extraction is performed, jet spray drying is performed, extraction nano-powder is obtained, lactose and dextrin are added, and the gongyankang granules are obtained. When used for treating acute pancreatitis, acute gastritis and other chronic pelvic inflammatory diseases, the gongyankang granules are obviously superior to commercially-available gongyankang granules in treatment effect and achieve a good effect.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of Fuyankan particles and preparation method thereof.
Background technology
Fuyankan particles blood circulation promoting and blood stasis dispelling, removing toxic substances and promoting subsidence of swelling.For chronic pelvic inflammatory disease.Commercially available Fuyankan particles is due to prescription and technological reason, and curative effect is not satisfactory, and preparation adopts traditional handicraft preparation, there is the shortcoming that curative effect is low.
Summary of the invention
The present invention, for overcoming above-mentioned deficiency, provides Fuyankan particles that a kind of curative effect is high and preparation method thereof.
Invention embodiment is as follows:
Get Herba Pogostemonis 75g, Pericarpium Granati 120g, Fructus Evodiae 7.5g, Radix Angelicae Sinensis 90g, Radix Cynanchi Paniculati 240g, Rhizoma Cyperi (vinegar system) 95g, Rhizoma Zingiberis Preparatum 81g, Herba Lycopi 80g, Flos Carthami 78g, Radix Bupleuri 75g, Sargassum 95g, Semen Plantaginis (salt is processed) 110g, be ground into 40 order coarse powder, put in circulating ultrasonic extractor, add 11465g water, 8 ~ 10g germanium powder, 6 ~ 10g polysorbate60, selects supersonic frequency 55 ~ 65KHz, pressure 0.3 ~ 0.5Mpa extracts 30 minutes, uses 80 mesh screen, obtains extracting solution; Getting extracting solution puts in jet spray dryer, and control inlet temperature 35 ~ 45 DEG C, pressure 0.02 ~ 0.04Mpa, 400 ~ 600 meters per second of flow velocity, obtains nanometer extract powder; Get extract powder and add lactose 400g, dextrin 100g, use water wet granulation, 60 DEG C of dryings, granulate, adds Talcum 25g, mixing, obtained Fuyankan particles.
The raw material standards that above-mentioned embodiment is mentioned is as follows:
Herba Pogostemonis: China's coastal port one ministerial standard.This product is that labiate extensively stores fragrant Pogostemoncablin(Blanco) dry aerial parts of Benth..Tap when branch and leaf are luxuriant, Exposure to Sunlight is vexed for night, repeatedly to dry.
Pericarpium Granati: China's coastal port one ministerial standard.This product is the dry peel of Punicaceae plant Punica granatum L. PunicagranatumL..Autumn collects peel after fruit maturation, dries.
Fructus Evodiae: China's coastal port one ministerial standard.This product is luxuriant growth savoury herb Fructus Evodiae Evodiarutaecarpa(Juss.) Benth., Shi Hu Evodiarutaecarpa(Juss.) Benth.var.officina-lis(Dode) Huang or thin hair Fructus Evodiae Evodiarutaecarpa(Juss.) Benth.var.bodinieri(Dode) the dry almost ripe fruit of Huang.When the 8-11 month, fruit not yet ftractureed, cut Fruit branch, dry or cold drying. except impurity such as debranching, leaf, carpopodiums.
Radix Angelicae Sinensis: China's coastal port one ministerial standard.This product is umbelliferae angelica Angelicasinensis(Oliv.) dry root of Diels.Autumn end excavates, and removing fibrous root and silt, after moisture slightly evaporates, be bundled into wisp, upper canopy, with pyrotechnics slowly smoke-dried beancurd.
Radix Cynanchi Paniculati: China's coastal port one ministerial standard.This product is asclepiadaceae plant Radix Cynanchi Paniculati CynanCHUMpaniculatum(Bge.) the dry root and rhizome of Kitag..Autumn excavates, and removing impurity, dries in the shade.
Rhizoma Cyperi (vinegar system): China's coastal port one ministerial standard.This product is the dry rhizome of sedge dried tuber CyperusrotundusL..Autumn excavates, sing the hair must, put in boiling water after slightly boiling or steaming and dry. or burn and directly to dry afterwards.
Rhizoma Zingiberis Preparatum: China's coastal port one ministerial standard.This product is the Preparation process product of Rhizoma Zingiberis.
Herba Lycopi: China's coastal port one ministerial standard.This product is the dry aerial parts of labiate hair leaf lycopus lucidus LycopuslucidusTurcz.var.hirtusRegel.Summer, autumn two tap when season, stem and leaf was luxuriant, dry.
Flos Carthami: China's coastal port one ministerial standard.This product is the dried floral of feverfew Flos Carthami CarthamustinctoriusL..Pluck when summer, flower was red by xanthochromia, dry in the shade or dry.
Radix Bupleuri: China's coastal port one ministerial standard.This product is the dry root of umbelliferae bupleurum BupleurumchinenseDC. or Radix Bupeuri Scorzonerfolii. BupleurumscocrzonerifoliumWilld..Different by character, practise title " Radix Bupleuri " and " Radix Bupleuri Scorzonerifolii " respectively.Spring, Qiu Erji excavate, removing stem and leaf and silt, dry.
Sargassum: China's coastal port one ministerial standard.This product is Sargassaceae plant Sargassum Sareassumpallidum(Turn.) C.Ag. or Sargassum fusiforme (Harv.) Setch Sargassumfusiforme(Hary.) the dry frond of Setch..The former practises title " compatibile ", and the latter practises title " lobule Sargassum ".Summer, Qiu Erji fish, and removing impurity, cleans, dry.
Semen Plantaginis: China's coastal port one ministerial standard.This product is the dry mature seed of Plantaginaceae plant Herba Plantaginis PlantagoasiaticaL. or Plantago depressa Willd PlantagodepressaWilld..To gather when summer, autumn two season seed maturity fruit ear, dry, rub seed, removing impurity.
Germanium powder: germanium dioxide: No. CAS: 1310-53-8: industry standard: lark prestige Science and Technology Ltd.;
Polysorbate60: Chinese Pharmacopoeia version two ministerial standard in 2010;
Lactose: Chinese Pharmacopoeia version two ministerial standard in 2010;
Dextrin: Chinese Pharmacopoeia version two ministerial standard in 2010;
Pulvis Talci: Chinese Pharmacopoeia version one ministerial standard in 2010;
Raw material used by above Fuyankan particles all can be bought from pharmaceuticals and obtain, and is not limited to typical production producer, all can be used to implement the present invention program as long as meet quality standard.
The key equipment that foregoing invention embodiment is mentioned is as follows:
Circulating ultrasonic machine: supersonic frequency 20 ~ 100KHz,
(typical production producer: Beijing Hongxianglong Biotechnology Development Co., Ltd)
Jet spray dryer: inlet temperature scope 30 ~ 70 DEG C, 300 ~ 900 meters per second of effluxvelocity scope;
(typical production producer: Nai Nuo bio tech ltd, Beijing)
Raw material used by above Fuyankan particles all can be bought from pharmaceuticals and obtain, and all can be used to implement the present invention program as long as meet national standard.
In foregoing invention scheme, term used is pharmacy proprietary term, as Chinese Pharmacopoeia regulation and pharmaceutical practice of being correlated with all are deferred in " decompression ", " vinegar system " etc.
Unit g in the present invention also can be other weight portion, does not affect the enforcement of the present invention program.
Equipment Market described in the present invention program all has sale, is not limited to typical production producer, as long as technical specification can reach requirement, all can be used to realize the present invention.
Detailed description of the invention
Specific embodiments of the invention 1
Get Herba Pogostemonis 75g, Pericarpium Granati 120g, Fructus Evodiae 7.5g, Radix Angelicae Sinensis 90g, Radix Cynanchi Paniculati 240g, Rhizoma Cyperi (vinegar system) 95g, Rhizoma Zingiberis Preparatum 81g, Herba Lycopi 80g, Flos Carthami 78g, Radix Bupleuri 75g, Sargassum 95g, Semen Plantaginis (salt is processed) 110g, be ground into 40 order coarse powder, put in circulating ultrasonic extractor, add 11465g water, 8g germanium powder, 6g polysorbate60, selects supersonic frequency 55KHz, pressure 0.3Mpa extracts 30 minutes, uses 80 mesh screen, obtains extracting solution; Getting extracting solution puts in jet spray dryer, and control inlet temperature 35 DEG C, pressure 0.02Mpa, 400 meters per second of flow velocity, obtains nanometer extract powder; Get extract powder and add lactose 400g, dextrin 100g, use water wet granulation, 60 DEG C of dryings, granulate, adds Talcum 25g, mixing, obtained Fuyankan particles.
Specific embodiments of the invention 2
Get Herba Pogostemonis 75g, Pericarpium Granati 120g, Fructus Evodiae 7.5g, Radix Angelicae Sinensis 90g, Radix Cynanchi Paniculati 240g, Rhizoma Cyperi (vinegar system) 95g, Rhizoma Zingiberis Preparatum 81g, Herba Lycopi 80g, Flos Carthami 78g, Radix Bupleuri 75g, Sargassum 95g, Semen Plantaginis (salt is processed) 110g, be ground into 40 order coarse powder, put in circulating ultrasonic extractor, add 11465g water, 10g germanium powder, 10g polysorbate60, selects supersonic frequency 65KHz, pressure 0.5Mpa extracts 30 minutes, uses 80 mesh screen, obtains extracting solution; Getting extracting solution puts in jet spray dryer, and control inlet temperature 45 DEG C, pressure 0.04Mpa, 600 meters per second of flow velocity, obtains nanometer extract powder; Get extract powder and add lactose 400g, dextrin 100g, use water wet granulation, 60 DEG C of dryings, granulate, adds Talcum 25g, mixing, obtained Fuyankan particles.
Specific embodiments of the invention 3
Get Herba Pogostemonis 75g, Pericarpium Granati 120g, Fructus Evodiae 7.5g, Radix Angelicae Sinensis 90g, Radix Cynanchi Paniculati 240g, Rhizoma Cyperi (vinegar system) 95g, Rhizoma Zingiberis Preparatum 81g, Herba Lycopi 80g, Flos Carthami 78g, Radix Bupleuri 75g, Sargassum 95g, Semen Plantaginis (salt is processed) 110g, be ground into 40 order coarse powder, put in circulating ultrasonic extractor, add 11465g water, 9g germanium powder, 8g polysorbate60, selects supersonic frequency 60KHz, pressure 0.4Mpa extracts 30 minutes, uses 80 mesh screen, obtains extracting solution; Getting extracting solution puts in jet spray dryer, and control inlet temperature 40 DEG C, pressure 0.03Mpa, 500 meters per second of flow velocity, obtains nanometer extract powder; Get extract powder and add lactose 400g, dextrin 100g, use water wet granulation, 60 DEG C of dryings, granulate, adds Talcum 25g, mixing, obtained Fuyankan particles.
Above embodiment illustrates, adopts the extreme condition of embodiment of the present invention and optimal conditions all can make Fuyankan particles.Actual effect of the present invention is investigated below with the Fuyankan particles that embodiment 3 is obtained:
(1) embodiment 3 Fuyankan particles and commercially available Fuyankan particles treat chronic pelvic inflammatory disease Disease Clinical observation of curative effect
1 case scenario
Statistics outpatient service and inpatient, observe chronic pelvic inflammation case 100 example, 42 years old mean age altogether.Patient is divided into two groups, test group takes embodiment 3 Fuyankan particles, and matched group takes traditional Fuyankan particles.
2 efficacy assessment standards
According to new Chinese medicine guideline of clinical investigations tcm syndrome curative effect determinate standard:
Cure: tcm clinical practice symptom, sign disappear or substantially disappear, syndrome integral reduces >=95%.
Effective: tcm clinical practice symptom, sign are obviously improved, syndrome integral reduces >=70%.
Effective: tcm clinical practice symptom, sign all take a favorable turn, syndrome integral reduces >=30%.
Invalid: tcm clinical practice symptom, sign are all not improved or increase the weight of, syndrome integral reduces < 30%.
Computing formula: [before (before treatment the rear integration of integration-treatment) ÷ treatment integration] × 100%.
3 clinical observation result
Table 1 embodiment 3 Fuyankan particles and the contrast of commercially available Fuyankan particles clinical efficacy
Above-mentioned clinical observation on the therapeutic effect result shows, Fuyankan particles prepared by the present invention is when treating chronic pelvic inflammatory disease, evident in efficacy higher than commercially available Fuyankan particles, p < 0.05.
Claims (3)
1. treat a Chinese medicine for chronic pelvic inflammatory disease, it is characterized in that getting Herba Pogostemonis 75g, Pericarpium Granati 120g, Fructus Evodiae 7.5g, Radix Angelicae Sinensis 90g, Radix Cynanchi Paniculati 240g, Rhizoma Cyperi (vinegar system) 95g, Rhizoma Zingiberis Preparatum 81g, Herba Lycopi 80g, Flos Carthami 78g, Radix Bupleuri 75g, Sargassum 95g, Semen Plantaginis (salt is processed) 110g, be ground into 40 order coarse powder, put in circulating ultrasonic extractor, add 11465g water, 8 ~ 10g germanium powder, 6 ~ 10g polysorbate60, select supersonic frequency 55 ~ 65KHz, pressure 0.3 ~ 0.5Mpa extracts 30 minutes, uses 80 mesh screen, obtains extracting solution; Getting extracting solution puts in jet spray dryer, and control inlet temperature 35 ~ 45 DEG C, pressure 0.02 ~ 0.04Mpa, 400 ~ 600 meters per second of flow velocity, obtains nanometer extract powder; Get extract powder and add lactose 400g, dextrin 100g, use water wet granulation, 60 DEG C of dryings, granulate, adds Talcum 25g, mixing, obtained Fuyankan particles.
2. the preparation method of Chinese medicine according to claim 1, is characterized in that getting Herba Pogostemonis 75g, Pericarpium Granati 120g, Fructus Evodiae 7.5g, Radix Angelicae Sinensis 90g, Radix Cynanchi Paniculati 240g, Rhizoma Cyperi (vinegar system) 95g, Rhizoma Zingiberis Preparatum 81g, Herba Lycopi 80g, Flos Carthami 78g, Radix Bupleuri 75g, Sargassum 95g, Semen Plantaginis (salt is processed) 110g, be ground into 40 order coarse powder, put in circulating ultrasonic extractor, add 11465g water, 8 ~ 10g germanium powder, 6 ~ 10g polysorbate60, select supersonic frequency 55 ~ 65KHz, pressure 0.3 ~ 0.5Mpa extracts 30 minutes, uses 80 mesh screen, obtains extracting solution; Getting extracting solution puts in jet spray dryer, and control inlet temperature 35 ~ 45 DEG C, pressure 0.02 ~ 0.04Mpa, 400 ~ 600 meters per second of flow velocity, obtains nanometer extract powder; Get extract powder and add lactose 400g, dextrin 100g, use water wet granulation, 60 DEG C of dryings, granulate, adds Talcum 25g, mixing, obtained Fuyankan particles.
3. the preparation method of Chinese medicine according to claim 1, is characterized in that getting Herba Pogostemonis 75g, Pericarpium Granati 120g, Fructus Evodiae 7.5g, Radix Angelicae Sinensis 90g, Radix Cynanchi Paniculati 240g, Rhizoma Cyperi (vinegar system) 95g, Rhizoma Zingiberis Preparatum 81g, Herba Lycopi 80g, Flos Carthami 78g, Radix Bupleuri 75g, Sargassum 95g, Semen Plantaginis (salt is processed) 110g, is ground into 40 order coarse powder, puts in circulating ultrasonic extractor, add 11465g water, 9g germanium powder, 8g polysorbate60, selects supersonic frequency 60KHz, pressure 0.4Mpa extracts 30 minutes, uses 80 mesh screen, obtains extracting solution; Getting extracting solution puts in jet spray dryer, and control inlet temperature 40 DEG C, pressure 0.03Mpa, 500 meters per second of flow velocity, obtains nanometer extract powder; Get extract powder and add lactose 400g, dextrin 100g, use water wet granulation, 60 DEG C of dryings, granulate, adds Talcum 25g, mixing, obtained Fuyankan particles.
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Application publication date: 20160323 |