CN105412300A - Dried tangerine or orange peel extract and preparation method and application thereof - Google Patents
Dried tangerine or orange peel extract and preparation method and application thereof Download PDFInfo
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- CN105412300A CN105412300A CN201510867908.7A CN201510867908A CN105412300A CN 105412300 A CN105412300 A CN 105412300A CN 201510867908 A CN201510867908 A CN 201510867908A CN 105412300 A CN105412300 A CN 105412300A
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- pericarpium citri
- citri reticulatae
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- 239000000284 extract Substances 0.000 title claims abstract description 56
- 238000000605 extraction Methods 0.000 title claims abstract description 24
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 241000675108 Citrus tangerina Species 0.000 title abstract 10
- 239000000341 volatile oil Substances 0.000 claims abstract description 23
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims abstract description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 22
- 229910002092 carbon dioxide Inorganic materials 0.000 claims abstract description 11
- 239000001569 carbon dioxide Substances 0.000 claims abstract description 11
- 239000006228 supernatant Substances 0.000 claims abstract description 11
- 239000003814 drug Substances 0.000 claims abstract description 7
- 238000003815 supercritical carbon dioxide extraction Methods 0.000 claims description 21
- 239000000287 crude extract Substances 0.000 claims description 20
- 239000012141 concentrate Substances 0.000 claims description 15
- 206010029410 night sweats Diseases 0.000 claims description 11
- 230000036565 night sweats Effects 0.000 claims description 11
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical class [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 10
- 238000004108 freeze drying Methods 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 10
- 238000005406 washing Methods 0.000 claims description 10
- 235000013305 food Nutrition 0.000 claims description 3
- 239000000047 product Substances 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 abstract description 5
- 239000002994 raw material Substances 0.000 abstract description 5
- 230000001105 regulatory effect Effects 0.000 abstract description 5
- 210000000952 spleen Anatomy 0.000 abstract description 5
- 210000002784 stomach Anatomy 0.000 abstract description 4
- 238000005728 strengthening Methods 0.000 abstract description 4
- 230000036528 appetite Effects 0.000 abstract description 3
- 235000019789 appetite Nutrition 0.000 abstract description 3
- 210000001124 body fluid Anatomy 0.000 abstract description 3
- 239000010839 body fluid Substances 0.000 abstract description 3
- 210000000936 intestine Anatomy 0.000 abstract description 3
- 239000000049 pigment Substances 0.000 abstract description 3
- 230000035922 thirst Effects 0.000 abstract description 3
- 238000001035 drying Methods 0.000 abstract description 2
- 238000000926 separation method Methods 0.000 abstract description 2
- 239000007788 liquid Substances 0.000 abstract 3
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 235000003599 food sweetener Nutrition 0.000 abstract 1
- 230000008014 freezing Effects 0.000 abstract 1
- 238000007710 freezing Methods 0.000 abstract 1
- 239000003755 preservative agent Substances 0.000 abstract 1
- 230000002335 preservative effect Effects 0.000 abstract 1
- 239000012266 salt solution Substances 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 238000000194 supercritical-fluid extraction Methods 0.000 abstract 1
- 239000003765 sweetening agent Substances 0.000 abstract 1
- 239000008176 lyophilized powder Substances 0.000 description 11
- 230000000052 comparative effect Effects 0.000 description 9
- 230000000694 effects Effects 0.000 description 8
- 206010062717 Increased upper airway secretion Diseases 0.000 description 2
- 230000002421 anti-septic effect Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 208000026435 phlegm Diseases 0.000 description 2
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- 208000024891 symptom Diseases 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 206010003591 Ataxia Diseases 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 241000207199 Citrus Species 0.000 description 1
- 206010010947 Coordination abnormal Diseases 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 208000022531 anorexia Diseases 0.000 description 1
- 230000001166 anti-perspirative effect Effects 0.000 description 1
- 239000003213 antiperspirant Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
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- 235000008216 herbs Nutrition 0.000 description 1
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- 238000000034 method Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 208000028684 sweat gland disease Diseases 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 230000002618 waking effect Effects 0.000 description 1
- 238000003809 water extraction Methods 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The invention provides a dried tangerine or orange peel extract and belongs to the technical field of medicine processing. Preparation of the dried tangerine or orange peel extract includes the following steps that dried tangerine or orange peel is smashed, water with the weight 10-15 times that of the dried tangerine or orange peel is added for decoction, and crude extraction liquid and dried tangerine or orange peel residues are obtained through separation of a filter screen; the crude extraction liquid is centrifuged, supernatant liquid is taken, and vacuum concentration is performed so that concentrated matter can be obtained; fresh orange peel with the weight 0.1-1 time that of the dried tangerine or orange peel is taken and is smashed after being washed through a saturated salt solution, the washed fresh orange peel is placed in a carbon dioxide supercritical extraction device to be extracted, and volatile oil is obtained; the dried tangerine or orange peel residues are smashed and evenly mixed with the concentrated matter and the volatile oil, vacuum freezing drying is performed, and the dried tangerine or orange peel extract is obtained. The dried tangerine or orange peel extract does not contain preservative, pigment or a sweetening agent, has the functions of encouraging production of body fluid to extinguish thirst, regulating the intestines and the stomach, regulating qi and strengthening the spleen, enhancing appetite and the like, and is high in safety, wide in raw material resource and low in preparation cost.
Description
Technical field
The invention belongs to pharmaceutical processing techniques field, particularly relate to a kind of Pericarpium Citri Reticulatae extract and its production and use.
Background technology
Pericarpium Citri Reticulatae is the dry mature skin of rue family citrus plant Fructus Citri tangerinae and variety thereof, as a kind of Chinese medicine material, and the fragrant and bitter in the mouth of gas, have and drive away dampness in body, regulating qi-flowing for strengthening spleen, the effects such as drying dampness to eliminate phlegm, cure mainly incoordination between the spleen and stomach, distension and fullness of the chest and abdomen, anorexia, cough ant phlegms etc., belong to integration of edible and medicinal herbs thing, security performance is good, applied range.
Night sweat is a disease name in Chinese medicine, be after falling asleep sweating abnormal, namely after waking up, antiperspirant is let out is only a kind of symptom of feature.Caused by the reasons such as the traditional Chinese medical science thinks that night sweat is many because of exterior deficiency, gas deficiency of YIN heat.Infantile night sweat is Pediatric Clinic common disease, and by replenishing the calcium, zinc and trace element be difficult to the therapeutic effect that plays, there is no the good and Western medicine that side effect is little of therapeutic effect.
Chinese patent application 201110023459.X discloses a kind of Pericarpium Citri Reticulatae extract, this Pericarpium Citri Reticulatae extract take Pericarpium Citri Reticulatae as raw material, obtained by supercritical carbon dioxide extraction, water extraction or organic solvent extraction, and disclose obtained Pericarpium Citri Reticulatae extract preparation there is the application of putting on weight in the health food of effect, but the active component in this Pericarpium Citri Reticulatae extract is more single, the residue after Pericarpium Citri Reticulatae extraction is not made full use of.
Chinese patent application 201210516457.9 discloses a kind of Pericarpium Citri Reticulatae extract, after adding alcohol reflux by Pericarpium Citri Reticulatae, concentrated, obtained after separation and purification, and disclose the effect that obtained Pericarpium Citri Reticulatae extract has blood fat reducing, but its preparation method is complicated, and active component in obtained Pericarpium Citri Reticulatae extract is more single, does not make full use of the residue after Pericarpium Citri Reticulatae extracts.
Summary of the invention
For solving problems of the prior art, the invention provides a kind of Pericarpium Citri Reticulatae extract, not containing antiseptic, pigment and sweeting agent, having promoting the production of body fluid to quench thirst, regulate the intestines and stomach, regulating qi-flowing for strengthening spleen, the effects such as appetite stimulator, safety is high, and raw material sources are extensive, and preparation cost is low.
The invention provides a kind of Pericarpium Citri Reticulatae extract, the preparation of described Pericarpium Citri Reticulatae extract comprises the steps:
A) pulverized by Pericarpium Citri Reticulatae, add the soak by water of described Pericarpium Citri Reticulatae 10 ~ 15 times of weight, filter screen is separated and obtains crude extract and Pericarpium Citri Reticulatae residue;
B) by centrifugal for described crude extract, get supernatant, concentrating under reduced pressure, obtain concentrate;
C) get the new fresh orange peel of described Pericarpium Citri Reticulatae 0.1 ~ 1 times of weight, after saturated common salt water washing, pulverize, be placed in supercritical carbon dioxide extraction apparatus extraction and obtain volatile oil;
D) pulverized by described Pericarpium Citri Reticulatae residue, mix homogeneously with described concentrate and described volatile oil, vacuum lyophilization, obtains Pericarpium Citri Reticulatae extract.
Preferably, described step B) in, centrifugal condition is the centrifugal 15 ~ 20min of 1000 ~ 5000g; Concentrating under reduced pressure condition is 70 ~ 90 DEG C and is evaporated to 1.25 ~ 1.4 Baume degrees.
Preferably, described step C) in, the weight of described new fresh orange peel is described Pericarpium Citri Reticulatae 0.1 ~ 0.4 times.
Preferably, the condition of described supercritical carbon dioxide extraction is carbon dioxide flow is 20 ~ 30L/h, and pressure is 15 ~ 25MPa, and temperature is 35 ~ 45 DEG C, and extraction time is 1.5 ~ 2h.
Correspondingly, present invention also offers the preparation method of Pericarpium Citri Reticulatae extract, comprise the steps:
A) pulverized by Pericarpium Citri Reticulatae, add the soak by water of described Pericarpium Citri Reticulatae 10 ~ 15 times of weight, filter screen is separated and obtains crude extract and Pericarpium Citri Reticulatae residue;
B) by centrifugal for described crude extract, get supernatant, concentrating under reduced pressure, obtain concentrate;
C) get the new fresh orange peel of described Pericarpium Citri Reticulatae 0.1 ~ 1 times of weight, after saturated common salt water washing, pulverize, be placed in supercritical carbon dioxide extraction apparatus extraction and obtain volatile oil;
D) pulverized by described Pericarpium Citri Reticulatae residue, mix homogeneously with described concentrate and described volatile oil, vacuum lyophilization, obtains Pericarpium Citri Reticulatae extract.
Preferably, described step B) in, centrifugal condition is the centrifugal 15 ~ 20min of 1000 ~ 5000g; Concentrating under reduced pressure condition is 70 ~ 90 DEG C and is evaporated to 1.25 ~ 1.4 Baume degrees.
Preferably, described step C) in, the weight of described new fresh orange peel is described Pericarpium Citri Reticulatae 0.1 ~ 0.4 times.
Preferably, the condition of described supercritical carbon dioxide extraction is carbon dioxide flow is 20 ~ 30L/h, and pressure is 15 ~ 25MPa, and temperature is 35 ~ 45 DEG C, and extraction time is 1.5 ~ 2h.
In addition, the present invention also provides Pericarpium Citri Reticulatae extract preparing the purposes in food, health product or the medicine preventing and treating/treat infantile night sweat.
Compared with prior art, the invention has the beneficial effects as follows: Pericarpium Citri Reticulatae extract provided by the invention, not containing antiseptic, pigment and sweeting agent, with Pericarpium Citri Reticulatae and new fresh orange peel for raw material, achieve making full use of of active component in volatile oil, concentrate and residue, there is promoting the production of body fluid to quench thirst, regulate the intestines and stomach, regulating qi-flowing for strengthening spleen, the effects such as appetite stimulator, safety is high, and raw material sources are extensive, preparation method is simple, and preparation cost is low.Present invention also offers Pericarpium Citri Reticulatae extract preparing the purposes in food, health product or the medicine preventing and treating/treat infantile night sweat, having widened the purposes of Pericarpium Citri Reticulatae, also for the treatment of infantile night sweat provides new selection.
Detailed description of the invention
Below by specific embodiment, the present invention is described in further detail.
embodiment one Pericarpium Citri Reticulatae extract
Get the Pericarpium Citri Reticulatae of 10 parts by weight, pulverize, add the soak by water 5h of 120 parts by weight, filter screen is separated and obtains crude extract and Pericarpium Citri Reticulatae residue; By crude extract in the centrifugal 15min of 2000g, get supernatant, 75 DEG C are evaporated to 1.3 Baume degrees; Get the new fresh orange peel of 2 parts by weight, after saturated common salt water washing, pulverize, be placed in supercritical carbon dioxide extraction apparatus extraction and obtain volatile oil, the condition of supercritical carbon dioxide extraction is carbon dioxide flow is 25L/h, and pressure is 20MPa, temperature is 35 DEG C, and extraction time is 1.5h; Pulverized by described Pericarpium Citri Reticulatae residue, mix homogeneously with concentrate and volatile oil, vacuum lyophilization 10h, obtains Pericarpium Citri Reticulatae extract lyophilized powder.
embodiment two Pericarpium Citri Reticulatae extract
Get the Pericarpium Citri Reticulatae of 10 parts by weight, pulverize, add the soak by water 5h of 150 parts by weight, filter screen is separated and obtains crude extract and Pericarpium Citri Reticulatae residue; By crude extract in the centrifugal 15min of 2000g, get supernatant, 85 DEG C are evaporated to 1.25 Baume degrees; Get the new fresh orange peel of 4 parts by weight, after saturated common salt water washing, pulverize, be placed in supercritical carbon dioxide extraction apparatus extraction and obtain volatile oil, the condition of supercritical carbon dioxide extraction is carbon dioxide flow is 25L/h, and pressure is 20MPa, temperature is 35 DEG C, and extraction time is 1.5h; Pulverized by described Pericarpium Citri Reticulatae residue, mix homogeneously with concentrate and volatile oil, vacuum lyophilization 10h, obtains Pericarpium Citri Reticulatae extract lyophilized powder.
embodiment three Pericarpium Citri Reticulatae extract
Get the Pericarpium Citri Reticulatae of 10 parts by weight, pulverize, add the soak by water 5h of 120 parts by weight, filter screen is separated and obtains crude extract and Pericarpium Citri Reticulatae residue; By crude extract in the centrifugal 15min of 2000g, get supernatant, 75 DEG C are evaporated to 1.3 Baume degrees; Get the new fresh orange peel of 3 parts by weight, after saturated common salt water washing, pulverize, be placed in supercritical carbon dioxide extraction apparatus extraction and obtain volatile oil, the condition of supercritical carbon dioxide extraction is carbon dioxide flow is 25L/h, and pressure is 20MPa, temperature is 35 DEG C, and extraction time is 1.5h; Pulverized by described Pericarpium Citri Reticulatae residue, mix homogeneously with concentrate and volatile oil, vacuum lyophilization 10h, obtains Pericarpium Citri Reticulatae extract lyophilized powder.
comparative example one Pericarpium Citri Reticulatae extract
Get the Pericarpium Citri Reticulatae of 10 parts by weight, pulverize, add the soak by water 5h of 120 parts by weight, filter screen is separated and obtains crude extract; By crude extract in the centrifugal 15min of 2000g, get supernatant, 75 DEG C are evaporated to 1.3 Baume degrees; Get the new fresh orange peel of 2 parts by weight, after saturated common salt water washing, pulverize, be placed in supercritical carbon dioxide extraction apparatus extraction and obtain volatile oil, the condition of supercritical carbon dioxide extraction is carbon dioxide flow is 25L/h, and pressure is 20MPa, temperature is 35 DEG C, and extraction time is 1.5h; By concentrate and volatile oil mix homogeneously, vacuum lyophilization 10h, obtains Pericarpium Citri Reticulatae extract lyophilized powder.
comparative example two Pericarpium Citri Reticulatae extract
Get the Pericarpium Citri Reticulatae of 10 parts by weight, pulverize, add the soak by water 5h of 120 parts by weight, filter screen is separated and obtains crude extract and Pericarpium Citri Reticulatae residue; By crude extract in the centrifugal 15min of 2000g, get supernatant, 75 DEG C are evaporated to 1.3 Baume degrees; Get the Pericarpium Citri Reticulatae of 2 parts by weight, after saturated common salt water washing, pulverize, be placed in supercritical carbon dioxide extraction apparatus extraction and obtain volatile oil, the condition of supercritical carbon dioxide extraction is carbon dioxide flow is 25L/h, and pressure is 20MPa, temperature is 35 DEG C, and extraction time is 1.5h; Pulverized by described Pericarpium Citri Reticulatae residue, mix homogeneously with concentrate and volatile oil, vacuum lyophilization 10h, obtains Pericarpium Citri Reticulatae extract lyophilized powder.
comparative example three Pericarpium Citri Reticulatae extract
Get the Pericarpium Citri Reticulatae of 10 parts by weight, pulverize, add the soak by water 5h of 120 parts by weight, filter screen is separated and obtains crude extract and Pericarpium Citri Reticulatae residue; By crude extract in the centrifugal 15min of 2000g, get supernatant, 75 DEG C are evaporated to 1.3 Baume degrees; Get the new fresh orange peel of 8 parts by weight, after saturated common salt water washing, pulverize, be placed in supercritical carbon dioxide extraction apparatus extraction and obtain volatile oil, the condition of supercritical carbon dioxide extraction is carbon dioxide flow is 25L/h, and pressure is 20MPa, temperature is 35 DEG C, and extraction time is 1.5h; Pulverized by described Pericarpium Citri Reticulatae residue, mix homogeneously with concentrate and volatile oil, vacuum lyophilization 10h, obtains Pericarpium Citri Reticulatae extract lyophilized powder.
the efficacy assessments of Pericarpium Citri Reticulatae extract in treatment infantile night sweat
Convene 300 infantile night sweat patient volunteers, the age, between 5 ~ 8 years old, is divided into 5 groups at random, often organize 60 people, take the Pericarpium Citri Reticulatae extract that embodiment one, embodiment two, comparative example one, comparative example two and comparative example three is obtained respectively, every day 3 times, each 5g, takes after mixing it with hot water, takes 15 days continuously.
Infantile night sweat feedback result after 15 days is: take in the patient volunteer of the obtained Pericarpium Citri Reticulatae extract lyophilized powder of embodiment one, and 43 people have and obviously or significantly improve, and 10 people slightly improve, 7 people without improvement also without discomfort; Take in the patient volunteer of the obtained Pericarpium Citri Reticulatae extract lyophilized powder of embodiment two, 41 people have and obviously or significantly improve, and 11 people slightly improve, 8 people without improvement also without discomfort; Take in the patient volunteer of the obtained Pericarpium Citri Reticulatae extract lyophilized powder of comparative example one, 26 people have and obviously or significantly improve, and 19 people slightly improve, 15 people without improvement also without discomfort; Take in the patient volunteer of the obtained Pericarpium Citri Reticulatae extract lyophilized powder of comparative example two, 22 people have and obviously or significantly improve, and 18 people slightly improve, 20 people without improvement also without discomfort; Take in the patient volunteer of the obtained Pericarpium Citri Reticulatae extract lyophilized powder of comparative example three, 21 people have and obviously or significantly improve, and 18 people slightly improve, and 14 people are without improvement also without discomfort, and 7 people do not feel like oneself and occur the symptoms such as digestive functional disturbance.
In sum, Pericarpium Citri Reticulatae extract provided by the invention has good effect in treatment infantile night sweat, and safety is good, can not cause side effect.
Above content is in conjunction with concrete preferred implementation further description made for the present invention, can not assert that specific embodiment of the invention is confined to these explanations.For general technical staff of the technical field of the invention, without departing from the inventive concept of the premise, some simple deduction or replace can also be made, all should be considered as belonging to protection scope of the present invention.
Claims (9)
1. a Pericarpium Citri Reticulatae extract, is characterized in that: the preparation of described Pericarpium Citri Reticulatae extract comprises the steps:
A) pulverized by Pericarpium Citri Reticulatae, add the soak by water of described Pericarpium Citri Reticulatae 10 ~ 15 times of weight, filter screen is separated and obtains crude extract and Pericarpium Citri Reticulatae residue;
B) by centrifugal for described crude extract, get supernatant, concentrating under reduced pressure, obtain concentrate;
C) get the new fresh orange peel of described Pericarpium Citri Reticulatae 0.1 ~ 1 times of weight, after saturated common salt water washing, pulverize, be placed in supercritical carbon dioxide extraction apparatus extraction and obtain volatile oil;
D) pulverized by described Pericarpium Citri Reticulatae residue, mix homogeneously with described concentrate and described volatile oil, vacuum lyophilization, obtains Pericarpium Citri Reticulatae extract.
2. Pericarpium Citri Reticulatae extract according to claim 1, is characterized in that: described step B) in, centrifugal condition is the centrifugal 15 ~ 20min of 1000 ~ 5000g; Concentrating under reduced pressure condition is 70 ~ 90 DEG C and is evaporated to 1.25 ~ 1.4 Baume degrees.
3. Pericarpium Citri Reticulatae extract according to claim 1, is characterized in that: described step C) in, the weight of described new fresh orange peel is described Pericarpium Citri Reticulatae 0.1 ~ 0.4 times.
4. Pericarpium Citri Reticulatae extract according to claim 1, is characterized in that: the condition of described supercritical carbon dioxide extraction is carbon dioxide flow is 20 ~ 30L/h, and pressure is 15 ~ 25MPa, and temperature is 35 ~ 45 DEG C, and extraction time is 1.5 ~ 2h.
5. the preparation method of Pericarpium Citri Reticulatae extract according to claim 1, is characterized in that: comprise the steps:
A) pulverized by Pericarpium Citri Reticulatae, add the soak by water of described Pericarpium Citri Reticulatae 10 ~ 15 times of weight, filter screen is separated and obtains crude extract and Pericarpium Citri Reticulatae residue;
B) by centrifugal for described crude extract, get supernatant, concentrating under reduced pressure, obtain concentrate;
C) get the new fresh orange peel of described Pericarpium Citri Reticulatae 0.1 ~ 1 times of weight, after saturated common salt water washing, pulverize, be placed in supercritical carbon dioxide extraction apparatus extraction and obtain volatile oil;
D) pulverized by described Pericarpium Citri Reticulatae residue, mix homogeneously with described concentrate and described volatile oil, vacuum lyophilization, obtains Pericarpium Citri Reticulatae extract.
6. Pericarpium Citri Reticulatae extract according to claim 5, is characterized in that: described step B) in, centrifugal condition is the centrifugal 15 ~ 20min of 1000 ~ 5000g; Concentrating under reduced pressure condition is 70 ~ 90 DEG C and is evaporated to 1.25 ~ 1.4 Baume degrees.
7. Pericarpium Citri Reticulatae extract according to claim 5, is characterized in that: described step C) in, the weight of described new fresh orange peel is described Pericarpium Citri Reticulatae 0.1 ~ 0.4 times.
8. Pericarpium Citri Reticulatae extract according to claim 5, is characterized in that: the condition of described supercritical carbon dioxide extraction is carbon dioxide flow is 20 ~ 30L/h, and pressure is 15 ~ 25MPa, and temperature is 35 ~ 45 DEG C, and extraction time is 1.5 ~ 2h.
9. Pericarpium Citri Reticulatae extract according to any one of claim 1 to 8 is preparing the purposes in the food of control/treatment infantile night sweat, health product or medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510867908.7A CN105412300A (en) | 2015-12-02 | 2015-12-02 | Dried tangerine or orange peel extract and preparation method and application thereof |
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| CN201510867908.7A CN105412300A (en) | 2015-12-02 | 2015-12-02 | Dried tangerine or orange peel extract and preparation method and application thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106036268A (en) * | 2016-05-27 | 2016-10-26 | 深圳市东鹏饮料实业有限公司 | Method for making dried orange peel beverage through composite enzymolysis of dried orange peel |
| CN109349405A (en) * | 2018-10-31 | 2019-02-19 | 广西梧州双钱实业有限公司 | A kind of moistening lung to arrest cough ointment and preparation method |
-
2015
- 2015-12-02 CN CN201510867908.7A patent/CN105412300A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106036268A (en) * | 2016-05-27 | 2016-10-26 | 深圳市东鹏饮料实业有限公司 | Method for making dried orange peel beverage through composite enzymolysis of dried orange peel |
| CN109349405A (en) * | 2018-10-31 | 2019-02-19 | 广西梧州双钱实业有限公司 | A kind of moistening lung to arrest cough ointment and preparation method |
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Application publication date: 20160323 |