CN105396632B - Liquid drop collection device based on micro-fluidic chip - Google Patents
Liquid drop collection device based on micro-fluidic chip Download PDFInfo
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- CN105396632B CN105396632B CN201510924387.4A CN201510924387A CN105396632B CN 105396632 B CN105396632 B CN 105396632B CN 201510924387 A CN201510924387 A CN 201510924387A CN 105396632 B CN105396632 B CN 105396632B
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- micro
- fluidic chip
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- liquid
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
Abstract
The invention discloses a liquid drop collection device based on a micro-fluidic chip. The device comprises a fixed holder. A liquid drop collector and a micro-fluidic chip are installed on the fixed holder. The liquid drop collector contains a collection liquid. A plurality of pipes are formed in the micro-fluidic chip in the vertical direction. Two ends of each pipe are communicated. The pipes are communicated with the collection liquid in the liquid drop collector. The micro-fluidic chip is located directly above or under the liquid drop collector. The device can generate batch precursor liquid drops with uniform heights rapidly. The chip contacts the collection liquid directly. The generated liquid drops enter into the collection liquid from the outlet, and liquid flow disturbance and liquid drop fusion are avoided. UV can be selected to cure liquid drops at a collection curing module, and therefore multifunctional polymer particles are obtained. The liquid drop products generated by the liquid drop collection device can be used in fields of nutriology, cosmetic and material science.
Description
Technical field
The application is related to a kind of droplet collection device based on micro-fluidic chip, and the drop product of generation can be used for Ru Ying
Support, cosmetics and material science.
Background technology
Microflow control technique (Microfluidics) is the emerging technology for preparing microemulsion, and it is to hundreds of micro- by tens of
The passage of metrical scale is processing or manipulate the Science and Technology system of a small amount of (10-9 to 10-18L) fluid.By change oil or
The component of the aqueous solution, can prepare the microemulsion being widely used in medicine, food, cosmetic field, and emulsion is polymerized just
Obtain multi-functional polymer particle.
At present, the process that microflow control technique prepares microemulsion is generation forerunner's precursor emulsion liquid first in micro-fluidic chip
Drop, then, drop is entered in reception liquid by external pipe and collected, and the microemulsion for preparing photopolymerization typically receives microemulsion
Collect and carry out in vessel illumination or directly carry out photopolymerization in pipeline.However, when drop flows through pipeline, due to disturbing for fluid
Dynamic, droplet coalescence phenomenon clearly, has a strong impact on the monodispersity and shape of the drop for obtaining.In addition, Jing said process is produced
The speed of raw drop is compared with slow and amount of droplets is few, it is difficult to prepares polymer particle in a large number, limits it at aspects such as biomedicines
Application.
The content of the invention
It is an object of the invention to provide a kind of droplet collection device based on micro-fluidic chip, effectively prevent liquid flow
Dynamic disturbance and droplet coalescence.
For achieving the above object, the present invention provides following technical scheme：
The embodiment of the present application discloses a kind of droplet collection device based on micro-fluidic chip, including fixed support, described solid
Drip collector and micro-fluidic chip are installed on fixed rack, collection liquid is contained with the drip collector, it is described micro-fluidic
Chip vertically offers the pipeline that a plurality of two ends communicate, the collection liquid phase in the pipeline and the drip collector
Logical, the micro-fluidic chip is located at the surface or underface of the drip collector.
Preferably, in above-mentioned droplet collection device, the fixed support includes base and is fixed on the base
On two fix bars, be fixed with the first collector fixed seat, the drip collector and miniflow between two fix bars
Control chip is individually fixed in the two ends of the first collector fixed seat, offer in the first collector fixed seat respectively with
The micro-fluidic chip pipeline and the through hole of collection liquid connection.
Preferably, in above-mentioned droplet collection device, the liquid feeding end of the micro-fluidic chip is fixed on fixture, described
Fixture includes the first cover plate and the second cover plate being oppositely arranged, and between first cover plate and the second cover plate elastic washer is fixed with
And conduit, one end of the conduit is inserted in the elastic washer and communicates with the pipeline of the micro-fluidic chip, described to lead
The other end of pipe is connected with fluid injector.
Preferably, in above-mentioned droplet collection device, pass through between the fixture and the first collector fixed seat
Screw rod is fixed.
Preferably, in above-mentioned droplet collection device, the drip collector is the quartz ampoule for communicating up and down.
Preferably, in above-mentioned droplet collection device, the side of the drip collector is placed with uviol lamp.
Preferably, in above-mentioned droplet collection device, the drip collector is located at the top of the micro-fluidic chip,
The top of the drip collector is fixed with the second collector fixed seat, and the second collector fixed seat is fixed on described two
Between fix bar.
Preferably, in above-mentioned droplet collection device, offer in the second collector fixed seat and the drop
The overfall that collector top communicates.
Preferably, in above-mentioned droplet collection device, the contact of the drip collector and the first collector fixed seat
Seal washer is provided between face.
Compared with prior art, it is an advantage of the current invention that：
1. collector chips and collection liquid directly contact, the drop of generation is directly entered in collection liquid from outlet, it is to avoid
Liquid flow disturbance and droplet coalescence；
2. small volume, light weight, portability is strong, be readily disassembled cleaning；
3. overflowing port can conveniently take out unnecessary carrier fluid；
4. chip crosspoint and chip edge can be observed；
5. batch and highly homogeneous presoma drop can be produced quickly；
6. UV solidification drops can be selected curing module is collected, so as to obtain multi-functional polymer particle；
Chip in 7 fixtures is connected by packing ring in groove with quartzy fixed seat, and is fixed by standard screws, by elasticity
Packing ring is joined directly together PTFE tube road and chip pipeline, and dead volume is little；
Description of the drawings
In order to be illustrated more clearly that the embodiment of the present application or technical scheme of the prior art, below will be to embodiment or existing
The accompanying drawing to be used needed for having technology description is briefly described, it should be apparent that, drawings in the following description are only this
Some embodiments described in application, for those of ordinary skill in the art, on the premise of not paying creative work,
Can be with according to these other accompanying drawings of accompanying drawings acquisition.
Fig. 1 show the schematic perspective view of droplet collection device in the specific embodiment of the invention；
Fig. 2 show the perspective exploded view of droplet collection device in the specific embodiment of the invention.
Specific embodiment
Below in conjunction with the accompanying drawing in the embodiment of the present invention, detailed retouching is carried out to the technical scheme in the embodiment of the present invention
State, it is clear that described embodiment is only a part of embodiment of the invention, rather than the embodiment of whole.Based on the present invention
In embodiment, the every other enforcement that those of ordinary skill in the art are obtained on the premise of creative work is not made
Example, belongs to the scope of protection of the invention.
Shown in ginseng Fig. 1 and Fig. 2, based on the droplet collection device of micro-fluidic chip, including fixed support 1, on fixed support 1
It is provided with drip collector 2 and micro-fluidic chip 3, drip collector 2 and is contained with collection liquid, micro-fluidic chip 3 is along vertical side
To the pipeline that a plurality of two ends communicate is offered, pipeline is communicated with the collection liquid in drip collector, and micro-fluidic chip 3 is located at drop
The underface of collector.
In other embodiments, micro-fluidic chip 3 can also be located at the surface of drip collector.
Fixed support 1 includes base 101 and two fix bars 102 being fixed on base, solid between two fix bars
Surely there is the first collector fixed seat 103, drip collector 2 and micro-fluidic chip 3 are individually fixed in the first collector fixed seat 103
Two ends, offer the through hole for connecting with micro-fluidic chip pipeline and collection liquid respectively in the first collector fixed seat 103
1031。
The liquid feeding end of micro-fluidic chip 3 is fixed on fixture 4, and fixture 4 includes the first cover plate 401 and second being oppositely arranged
Cover plate 402, is fixed with elastic washer 403 and conduit between the first cover plate 401 and the second cover plate 402, one end of conduit is inserted in
Communicate in elastic washer 403 and with the pipeline of micro-fluidic chip 3, the other end of conduit is connected with fluid injector.
In the technical scheme, micro-fluidic chip is standard chips, and the standard chips are the hard that thickness and width are fixed
Chip, it is consistent with fixture inside dimensions, it is to avoid displacement.Chip passes through standard M4 spiral shell between fixture and the first collector fixed seat
Bar 406 is fixed.Adjustment packing ring and chip position guarantee the accurate connection of gasket position and chip, it is to avoid leakage.
Conduit preferably adopts polytetrafluoro quality of rubber materials, centre to be uniformly distributed four holes, and aperture is slightly less than PTFE catheter outer diameters,
Hole site is corresponding with standard chips stream position.PTFE conduits and polytetrafluoro caoutchouc elasticity packing ring are by the extruding of cover screw
Closely connection.Polytetrafluoro rubber washer overall dimensions are squeezed more than the gasket groove between the first cover plate and the second cover plate using screw
Pressure produces deformation, realizes closely connection.PTFE tube head is away from elastic washer exit about 1mm.
M3 screws 405 between first cover plate 401 and the second cover plate 402 by being engaged are fixed.
The two ends of the first collector fixed seat 103 are sheathed on respectively in two fix bars, and with two hex nuts 1032
It is fixed.
Preferably, drip collector is the quartz ampoule for communicating up and down.The side of drip collector is placed with uviol lamp.
Further, the top of drip collector is fixed with the second collector fixed seat 104, the second collector fixed seat
104 are fixed between two fix bars.The overfall communicated with drip collector top is offered in second collector fixed seat
1041.The two ends of the second collector fixed seat 104 are sheathed on respectively in two fix bars and by two goat's horn head nuts 1042
It is fixed.
Further, it is provided with seal washer 1033 between the contact surface of drip collector and the first collector fixed seat.
Using the preparation process of above-mentioned collection device batch emulsion：
Drip collector selects hard micro-fluidic chip, and under the promotion of micro-injection pump or constant pressure pump, two-phase is immiscible
Fluid single emulsion (W1/O, or O1/W) or double emulsions are produced first in standard chips, then under buoyancy and Action of Gravity Field
In being directly entered collection liquid, stable liquid flow is defined, quickly generate the liquid of batch and highly homogeneous presoma drop
Drop, the monodispersed emulsion droplet diameter range of generation is at 10-250 μm.Collector chips and collection liquid directly contact, produce
Drop be directly entered in collection liquid from outlet, it is to avoid liquid flow disturbance and droplet coalescence.
Wherein, the overfall for designing in the collector can conveniently pour out current-carrying liquid.Drop is solidified using UV, in quartzy tube side
Face is put into uviol lamp, can carry out ultra-violet curing, so that multi-functional polymer particle is obtained, so as to be applied to nutrition, cosmetics
With material science aspect.
It should be noted that herein, such as first and second or the like relational terms are used merely to a reality
Body or operation make a distinction with another entity or operation, and not necessarily require or imply these entities or deposit between operating
In any this actual relation or order.And, term " including ", "comprising" or its any other variant are intended to
Nonexcludability is included, so that a series of process, method, article or equipment including key elements not only will including those
Element, but also including other key elements being not expressly set out, or also include for this process, method, article or equipment
Intrinsic key element.In the absence of more restrictions, the key element for being limited by sentence "including a ...", it is not excluded that
Also there is other identical element in process, method, article or equipment including the key element.
The above is only the specific embodiment of the application, it is noted that for the ordinary skill people of the art
For member, on the premise of without departing from the application principle, some improvements and modifications can also be made, these improvements and modifications also should
It is considered as the protection domain of the application.
Claims (9)
1. a kind of droplet collection device based on micro-fluidic chip, it is characterised in that including fixed support, on the fixed support
Drip collector and micro-fluidic chip are installed, collection liquid is contained with the drip collector, the micro-fluidic chip is along perpendicular
Nogata is to the pipeline that a plurality of two ends communicate is offered, and the pipeline is communicated with the collection liquid in the drip collector, described micro-
Fluidic chip is located at the surface or underface of the drip collector, the micro-fluidic chip and collection liquid directly contact, should
The drop that micro-fluidic chip is produced is directly entered in collection liquid from its tube outlet.
2. the droplet collection device based on micro-fluidic chip according to claim 1, it is characterised in that：The fixed support
Including base and two fix bars being fixed on the base, between two fix bars the first collector is fixed with
Fixed seat, the drip collector and micro-fluidic chip are individually fixed in the both sides of the first collector fixed seat, and described
The through hole for connecting with the micro-fluidic chip pipeline and collection liquid respectively is offered in one collector fixed seat.
3. the droplet collection device based on micro-fluidic chip according to claim 2, it is characterised in that：The micro-fluidic core
The liquid feeding end of piece is fixed on fixture, and the fixture includes the first cover plate and the second cover plate being oppositely arranged, first cover plate
And second be fixed with elastic washer and conduit between cover plate, one end of the conduit be inserted in the elastic washer and with it is described
The pipeline of micro-fluidic chip is communicated, and the other end of the conduit is connected with fluid injector.
4. the droplet collection device based on micro-fluidic chip according to claim 3, it is characterised in that：The fixture and institute
State and fixed by screw rod between the first collector fixed seat.
5. the droplet collection device based on micro-fluidic chip according to claim 1, it is characterised in that：The drop is collected
Device is the quartz ampoule for communicating up and down.
6. the droplet collection device based on micro-fluidic chip according to claim 5, it is characterised in that：The drop is collected
The side of device is placed with uviol lamp.
7. the droplet collection device based on micro-fluidic chip according to claim 2, it is characterised in that：The drop is collected
Device is located at the top of the micro-fluidic chip, and the top of the drip collector is fixed with the second collector fixed seat, and described the
Two collector fixed seats are fixed between two fix bars.
8. the droplet collection device based on micro-fluidic chip according to claim 7, it is characterised in that：Described second collects
The overfall communicated with the drip collector top is offered in device fixed seat.
9. the droplet collection device based on micro-fluidic chip according to claim 2, it is characterised in that：The drop is collected
Seal washer is provided between the contact surface of device and the first collector fixed seat.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510924387.4A CN105396632B (en) | 2015-12-14 | 2015-12-14 | Liquid drop collection device based on micro-fluidic chip |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510924387.4A CN105396632B (en) | 2015-12-14 | 2015-12-14 | Liquid drop collection device based on micro-fluidic chip |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105396632A CN105396632A (en) | 2016-03-16 |
| CN105396632B true CN105396632B (en) | 2017-05-10 |
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| CN201510924387.4A Active CN105396632B (en) | 2015-12-14 | 2015-12-14 | Liquid drop collection device based on micro-fluidic chip |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107058080B (en) * | 2017-03-13 | 2020-08-04 | 中国科学院上海高等研究院 | Digital PCR chip based on ink-jet printing and preparation method thereof |
| CN107727838B (en) * | 2017-09-30 | 2019-10-25 | 西南大学 | A kind of micro waste collecting device suitable for micro-fluidic chip |
| CN115138416A (en) * | 2022-06-17 | 2022-10-04 | 安徽福贸生物科技有限公司 | Medical micro-fluidic chip liquid drop collection device |
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| US6506609B1 (en) * | 1999-05-17 | 2003-01-14 | Caliper Technologies Corp. | Focusing of microparticles in microfluidic systems |
| CN202322811U (en) * | 2011-11-24 | 2012-07-11 | 杭州电子科技大学 | Device for preparing I-type collagen gel particles and collecting cell microspheres |
| CN103113515A (en) * | 2013-02-28 | 2013-05-22 | 中国科学院长春应用化学研究所 | Magnetic porous polymer particle and preparation method thereof |
| CN103240043A (en) * | 2013-05-09 | 2013-08-14 | 四川大学 | Preparation method of monodisperse multicomponent multiple emulsion |
| CN104511320A (en) * | 2013-09-27 | 2015-04-15 | 王来 | A liquid-drop-generation capillary microfluidic chip and a preparing method thereof |
| CN205182756U (en) * | 2015-12-14 | 2016-04-27 | 苏州汶颢芯片科技有限公司 | Liquid drop collection device based on micro -fluidic chip |
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2015
- 2015-12-14 CN CN201510924387.4A patent/CN105396632B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6506609B1 (en) * | 1999-05-17 | 2003-01-14 | Caliper Technologies Corp. | Focusing of microparticles in microfluidic systems |
| CN202322811U (en) * | 2011-11-24 | 2012-07-11 | 杭州电子科技大学 | Device for preparing I-type collagen gel particles and collecting cell microspheres |
| CN103113515A (en) * | 2013-02-28 | 2013-05-22 | 中国科学院长春应用化学研究所 | Magnetic porous polymer particle and preparation method thereof |
| CN103240043A (en) * | 2013-05-09 | 2013-08-14 | 四川大学 | Preparation method of monodisperse multicomponent multiple emulsion |
| CN104511320A (en) * | 2013-09-27 | 2015-04-15 | 王来 | A liquid-drop-generation capillary microfluidic chip and a preparing method thereof |
| CN205182756U (en) * | 2015-12-14 | 2016-04-27 | 苏州汶颢芯片科技有限公司 | Liquid drop collection device based on micro -fluidic chip |
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| CN105396632A (en) | 2016-03-16 |
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Address after: 215808 Suzhou Industrial Park, Jiangsu Road, No. 128 Patentee after: SUZHOU WENHAO MICROFLUIDIC TECHNOLOGY Co.,Ltd. Address before: 215808 Suzhou Industrial Park, Jiangsu Road, No. 128 Patentee before: SUZHOU WENHAO CHIP TECHNOLOGY Co.,Ltd. |
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| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Droplet collection device based on microfluidic chip Effective date of registration: 20220905 Granted publication date: 20170510 Pledgee: Zhejiang Tailong Commercial Bank Co.,Ltd. Suzhou Branch Pledgor: SUZHOU WENHAO MICROFLUIDIC TECHNOLOGY Co.,Ltd. Registration number: Y2022320010504 |
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