CN105396499A - Electromagnetic stirring separation device for biopharmacy - Google Patents

Electromagnetic stirring separation device for biopharmacy Download PDF

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Publication number
CN105396499A
CN105396499A CN201510965358.2A CN201510965358A CN105396499A CN 105396499 A CN105396499 A CN 105396499A CN 201510965358 A CN201510965358 A CN 201510965358A CN 105396499 A CN105396499 A CN 105396499A
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converter
input
output
bio
central processing
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Granted
Application number
CN201510965358.2A
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Chinese (zh)
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CN105396499B (en
Inventor
杨毅红
邓辉红
蒋怀军
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Shandong Renhe Pharmaceutical Co ltd
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Zhongshan Houyuan Electronic Technology Co Ltd
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Priority to CN201510965358.2A priority Critical patent/CN105396499B/en
Publication of CN105396499A publication Critical patent/CN105396499A/en
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Publication of CN105396499B publication Critical patent/CN105396499B/en
Expired - Fee Related legal-status Critical Current
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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00Other mixers; Mixing plants; Combinations of mixers
    • B01F33/45Magnetic mixers; Mixers with magnetically driven stirrers
    • B01F33/453Magnetic mixers; Mixers with magnetically driven stirrers using supported or suspended stirring elements
    • B01F33/4532Magnetic mixers; Mixers with magnetically driven stirrers using supported or suspended stirring elements using a bearing, tube, opening or gap for internally supporting the stirring element
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/20Measuring; Control or regulation
    • B01F35/21Measuring
    • B01F35/211Measuring of the operational parameters
    • B01F35/2112Level of material in a container or the position or shape of the upper surface of the material
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/20Measuring; Control or regulation
    • B01F35/22Control or regulation
    • B01F35/2201Control or regulation characterised by the type of control technique used
    • B01F35/2203Controlling the mixing process by feed-forward, i.e. a parameter of the components to be mixed is measured and the feed values are calculated
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/2202Mixing compositions or mixers in the medical or veterinary field
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00Auxiliary or complementary information in relation with mixing
    • B01F2215/04Technical information in relation with mixing
    • B01F2215/0409Relationships between different variables defining features or parameters of the apparatus or process
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00Auxiliary or complementary information in relation with mixing
    • B01F2215/04Technical information in relation with mixing
    • B01F2215/0413Numerical information
    • B01F2215/0418Geometrical information
    • B01F2215/0431Numerical size values, e.g. diameter of a hole or conduit, area, volume, length, width, or ratios thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

The present invention provides an electromagnetic stirring separation device for biopharmacy. The device includes an operation surface, a body, a stirring base and a support bar. The outer surface of the operation surface comprises a display screen, a switch and an automatic switch; a support plate is fixedly mounted on the upper end face of the body; the body is internally provided with a cavity; the cavity is internally provided with a control unit, a variable-frequency power source and a sensor; and the control unit includes a printed circuit board and an A / D converter welded to the printed circuit board, an embedded central processing unit, a storage, a D / A converter, a relay and a battery. Compared with the prior art, the device provided by the present invention has the following beneficial effects: the device prevents inadvertent tough of switch by the staff in case of an accident leading to accidental opening of the device, so as to enhance the use safety; the device can be automatically controlled, and has the advantages of minimal impact on the pharmaceutically activity, high separation efficiency, easiness to use and operation, good stability and high reliability.

Description

A kind of electromagnetic agitation separator for bio-pharmaceuticals
Technical field
The present invention is a kind of electromagnetic agitation separator for bio-pharmaceuticals, belongs to bio-pharmaceuticals apparatus field.
Background technology
Separating and purifying technology is namely in the industry by suitable technological means and equipment, and expend certain energy to realize the separation process of mixture, common separate mode has Liquid liquid Separation and gas-liquid separation.For gas-liquid separation, gas-liquid separation mode of the prior art has a variety of, and corresponding device is also a lot, but bio-pharmaceuticals has its particularity, and some pharmaceutical compositions can not distill, because it at high temperature can lose activity.Could preserve for a long time after some medicines then need the solution gas in its liquid ingredients or bubble to discharge.At present for the liquid drug that can not heat, remove the solution gas in it, what mainly adopt is concussion and stirring two kinds of modes.But special there is bioactive medicine for some, the mode of shaking particularly ultrasonic oscillation degasification can make the active ingredient in it lose effect equally.Therefore the mode of stirring can only be adopted to carry out degasification.What mostly adopt in prior art is directly electric mixer is stretched into the mode carrying out in medicine stirring, but few for some doses, can not put into the medicine of agitator and inapplicable.
In sum, lack one in prior art and be exclusively used in low consumption of the liquid medicine, and the electromagnetic agitation separator for bio-pharmaceuticals of minimum stirring-type degasification is affected on pharmaceutically active.
Summary of the invention
For the deficiency that prior art exists, the object of the invention is to provide a kind of electromagnetic agitation separator for bio-pharmaceuticals, and to solve the problem proposed in above-mentioned background technology, the present invention is easy to use, convenient operation, good stability, and reliability is high.
To achieve these goals, the present invention realizes by the following technical solutions: a kind of electromagnetic agitation separator for bio-pharmaceuticals, comprise operating surface, main body, stir base and support bar, described operating surface is arranged on the front of main body, described operating surface outer surface comprises display screen and the switch that is arranged on below display screen and automatic switch, the inside of described switch is provided with pressure sensor, described stirring base is arranged on the top of gripper shoe, the inside of described stirring base is provided with LOAD CELLS, described gripper shoe is fixedly mounted on the upper surface of main body, described support bar is arranged on the rear of main body, the top of described support bar is provided with horizontal fixed bar, the front end of described horizontal fixed bar is connected with stirring rotator, the inside of described main body is provided with cavity, the inside of described cavity is provided with control unit, variable-frequency power sources and inductor, described variable-frequency power sources connects inductor by being electrically connected line, described control unit comprises printed circuit board and welding A/D converter on a printed circuit board, embedded central processing unit, holder, D/A converter, relay and battery, the output of described LOAD CELLS is connected with the input of A/D converter, the input of described A/D converter is also connected with the output of pressure sensor, the output of described A/D converter is connected with the input of embedded central processing unit, the output of described embedded central processing unit is connected with the input of D/A converter, the output of described D/A converter is connected with the input of relay, the output of described relay is connected with the input of variable-frequency power sources, and the output of described variable-frequency power sources is connected with the input of inductor.
Further, the bottom of described stirring rotator is placed in jar, and described jar is placed on and stirs above base.
Further, being arranged on the LOAD CELLS stirring chassis interior is a kind of resistance strain gage sensor.
Further, welding embedded central processing unit on a printed circuit board and holder are bi-directionally connected.
Further, described pressure sensor is a kind of diffuse silicon formula pressure sensor.
Further, described battery and LOAD CELLS, pressure sensor, A/D converter, embedded central processing unit, holder and D/A converter are electrically connected.
Beneficial effect of the present invention: a kind of electromagnetic agitation separator for bio-pharmaceuticals of the present invention, the existence of pressure sensor, false touch is to switch under fortuitous event to prevent staff, and unexpected unlatching situation of the present invention occurs, and adds safe handling type of the present invention.
Can Automated condtrol the present invention work, and minimum on pharmaceutically active impact, separative efficiency is high, and the present invention is easy to use, convenient operation, good stability, and reliability is high.
Accompanying drawing explanation
By reading the detailed description done non-limiting example with reference to the following drawings, other features, objects and advantages of the present invention will become more obvious:
Fig. 1 is the structural representation of a kind of electromagnetic agitation separator for bio-pharmaceuticals of the present invention;
Fig. 2 is the body interior structural representation of a kind of electromagnetic agitation separator for bio-pharmaceuticals of the present invention;
Fig. 3 is the printed circuit board structural representation of a kind of electromagnetic agitation separator for bio-pharmaceuticals of the present invention;
Fig. 4 is the operation principle block diagram of a kind of electromagnetic agitation separator for bio-pharmaceuticals of the present invention;
In figure: 1-operating surface, 2-main body, 3-stirs base, 4-support bar, 11-display screen, 12-switch, 13-automatic switch, 21-gripper shoe, 22-inductor, 23-cavity, 24-is electrically connected line, 25-variable-frequency power sources, 26-control unit, 31-LOAD CELLS, the horizontal fixed bar of 41-, 42-stirring rotator, 43-jar, 121-pressure sensor, 261-printed circuit board, 262-A/D converter, 263-embedded central processing unit, 264-holder, 265-D/A converter, 266-relay, 267-battery.
Detailed description of the invention
The technological means realized for making the present invention, creation characteristic, reaching object and effect is easy to understand, below in conjunction with detailed description of the invention, setting forth the present invention further.
Refer to Fig. 1, Fig. 2, Fig. 3 and Fig. 4, the invention provides a kind of technical scheme: a kind of electromagnetic agitation separator for bio-pharmaceuticals, comprise operating surface 1, main body 2, stir base 3 and support bar 4, operating surface 1 is arranged on the front of main body 2, operating surface 1 outer surface comprises display screen 11 and the switch 12 that is arranged on below display screen and automatic switch 13, the inside of switch 12 is provided with pressure sensor 121, stir the top that base 3 is arranged on gripper shoe 21, the inside of stirring base 3 is provided with LOAD CELLS 31, gripper shoe 21 is fixedly mounted on the upper surface of main body 2, support bar 4 is arranged on the rear of main body 2, the top of support bar 4 is provided with horizontal fixed bar 41, the front end of horizontal fixed bar 41 is connected with stirring rotator 42, the inside of main body 2 is provided with cavity 23, the inside of cavity 23 is provided with control unit 26, variable-frequency power sources 25 and inductor 22, variable-frequency power sources 25 connects inductor 22 by being electrically connected line 24, control unit 26 comprises printed circuit board 261 and is welded on the A/D converter 262 on printed circuit board 261, embedded central processing unit 263, holder 264, D/A converter 265, relay 266 and battery 267.
The output of LOAD CELLS 31 is connected with the input of A/D converter 262, the input of A/D converter 262 is also connected with the output of pressure sensor 121, the output of A/D converter 262 is connected with the input of embedded central processing unit 263, the output of embedded central processing unit 263 is connected with the input of D/A converter 265, the output of D/A converter 265 is connected with the input of relay 266, the output of relay 266 is connected with the input of variable-frequency power sources 25, the output of variable-frequency power sources 25 is connected with the input of inductor 22, welding embedded central processing unit 263 is on a printed circuit board bi-directionally connected with holder 264.
The bottom of stirring rotator 42 is placed in jar 43, jar 43 is placed on and stirs above base 3, being arranged on the LOAD CELLS 31 stirring base 3 inside is a kind of resistance strain gage sensor, pressure sensor 121 is a kind of diffuse silicon formula pressure sensor 121, battery 267 and LOAD CELLS 31, pressure sensor 121, A/D converter 262, embedded central processing unit 263, holder 264 and D/A converter 265 are electrically connected, battery 267 is for LOAD CELLS 31, pressure sensor 121, A/D converter 262, embedded central processing unit 263, power supply when holder 264 and D/A converter 265 work.
As one embodiment of the present of invention: before actual use, staff can input the critical value of a pressure in holder 264, when reality uses, staff is by by compressing switch 12 for controlling work of the present invention, the pressure sensor 121 of switch 12 inside can the place of detection staff be applied to force value size on switch 12, namely when the pressure of measured medium directly acts on the diaphragm of pressure sensor 121, diaphragm is made to produce the micrometric displacement be directly proportional to pressure medium, the resistance value of pressure sensor 121 is changed, with with this change of electronics wireline inspection, and change the canonical measure signal that output one corresponds to this pressure, being converted to a kind of digital quantity to A/D converter 262 is added in embedded central processing unit 263, embedded central processing unit 263 is by contrasting with the pressure threshold be stored in holder 264, if higher than this critical value, then can send a numerical control instruction, this numerical control instruction is after D/A converter 265 is changed, be added on relay 266, relay 266 is by controlling variable-frequency power sources 25, utilize the characteristic of magnetisable material two like magnetic poles repel each other, promote stirring rotator 42 by the polarity at the two ends constantly converting inductor 22 to rotate, then the step of liquid in jar 43 is completed, the existence of pressure sensor 121, prevent staff under fortuitous event false touch to switch 12, unexpected unlatching situation of the present invention occurs, add safe handling type of the present invention.
As one embodiment of the present of invention: before actual use, staff can input the critical value of a weight in holder 264, when reality uses, staff is by pressing automatic switch 13 for controlling work of the present invention, after this, battery 267 can be powered from trend LOAD CELLS 31, to make LOAD CELLS 31 automatic operation, when the object that staff need stir is placed in jar 43, LOAD CELLS 31 can need the weight of the object stirred in the place's of detection jar 43, the inside of LOAD CELLS 31 is provided with a metallic resistance silk, its length is L, the circle of cross section to be radius be r, its area is denoted as S, its resistivity is denoted as ρ, the Poisson's coefficient of this material is μ.When this root resistance wire is not by External Force Acting, its resistance value is R:
R=ρL/S(Ω)(2—1)
When its two ends are by the F masterpiece used time, will extend, that is produce distortion.If it extends Δ L, its cross-sectional area then reduces, and namely its cross section radius of circle reduces Δ r.In addition, going back Available experimental proves, after deformation, resistivity also can change this metallic resistance silk to some extent, is denoted as Δ ρ.
To demand perfection differential to formula (2--1), namely obtain after resistance wire extends, his resistance value changes how many.We have:
ΔR=ΔρL/S+ΔLρ/S–ΔSρL/S2(2—2)
Remove formula (2--2) by formula (2--1) to obtain
ΔR/R=Δρ/ρ+ΔL/L–ΔS/S(2—3)
In addition, we know the cross-sectional area S=π r2 of wire, then Δ s=2 π r* Δ r, so
ΔS/S=2Δr/r(2—4)
From the mechanics of materials, we know
Δr/r=-μΔL/L(2—5)
Wherein, when negative sign represents elongation, radial direction reduces.μ represents material transversal effect Poisson's coefficient.Wushu (2-4) (2-5) substitute into (2--3), have
ΔR/R=Δρ/ρ+ΔL/L+2μΔL/L
=(1+2μ(Δρ/ρ)/(ΔL/L))*ΔL/L
=K*ΔL/L(2--6)
Wherein
K=1+2μ+(Δρ/ρ)/(ΔL/L)(2--7)
Formula (2--6)) describe relation between the resistance change rate (resistance changes relatively) of resistance strain gage and resistance wire percentage elongation (length changes relatively), then the weight needing the object stirred is inferred in jar 43, this weight information can be changed a kind of digital quantity by A/D converter 262 and be added in embedded central processing unit 263, embedded central processing unit 263 is by contrasting with the pressure threshold be stored in holder 264, if higher than this critical value, then can send a numerical control instruction, this numerical control instruction is after D/A converter 265 is changed, be added on relay 266, relay 266 is by controlling variable-frequency power sources 25, utilize the characteristic of magnetisable material two like magnetic poles repel each other, promote stirring rotator 42 by the polarity at the two ends constantly converting inductor 22 to rotate, then the step of liquid in jar 43 is completed, then the step of Automated condtrol work of the present invention is realized, the present invention is easy to use, convenient operation, good stability, reliability is high.
More than show and describe general principle of the present invention and principal character and advantage of the present invention, to those skilled in the art, obviously the invention is not restricted to the details of above-mentioned one exemplary embodiment, and when not deviating from spirit of the present invention or essential characteristic, the present invention can be realized in other specific forms.Therefore, no matter from which point, all should embodiment be regarded as exemplary, and be nonrestrictive, scope of the present invention is limited by claims instead of above-mentioned explanation, and all changes be therefore intended in the implication of the equivalency by dropping on claim and scope are included in the present invention.Any Reference numeral in claim should be considered as the claim involved by limiting.
In addition, be to be understood that, although this description is described according to embodiment, but not each embodiment only comprises an independently technical scheme, this narrating mode of description is only for clarity sake, those skilled in the art should by description integrally, and the technical scheme in each embodiment also through appropriately combined, can form other embodiments that it will be appreciated by those skilled in the art that.

Claims (6)

1. the electromagnetic agitation separator for bio-pharmaceuticals, comprise operating surface, main body, stir base and support bar, it is characterized in that: described operating surface is arranged on the front of main body, described operating surface outer surface comprises display screen and the switch that is arranged on below display screen and automatic switch, the inside of described switch is provided with pressure sensor, described stirring base is arranged on the top of gripper shoe, the inside of described stirring base is provided with LOAD CELLS, described gripper shoe is fixedly mounted on the upper surface of main body, described support bar is arranged on the rear of main body, the top of described support bar is provided with horizontal fixed bar, the front end of described horizontal fixed bar is connected with stirring rotator, the inside of described main body is provided with cavity, the inside of described cavity is provided with control unit, variable-frequency power sources and inductor, described variable-frequency power sources connects inductor by being electrically connected line, described control unit comprises printed circuit board and welding A/D converter on a printed circuit board, embedded central processing unit, holder, D/A converter, relay and battery,
The output of described LOAD CELLS is connected with the input of A/D converter, the input of described A/D converter is also connected with the output of pressure sensor, the output of described A/D converter is connected with the input of embedded central processing unit, the output of described embedded central processing unit is connected with the input of D/A converter, the output of described D/A converter is connected with the input of relay, the output of described relay is connected with the input of variable-frequency power sources, and the output of described variable-frequency power sources is connected with the input of inductor.
2. a kind of electromagnetic agitation separator for bio-pharmaceuticals according to claim 1, is characterized in that: the bottom of described stirring rotator is placed in jar, and described jar is placed on and stirs above base.
3. a kind of electromagnetic agitation separator for bio-pharmaceuticals according to claim 1, is characterized in that: being arranged on the LOAD CELLS stirring chassis interior is a kind of resistance strain gage sensor.
4. a kind of electromagnetic agitation separator for bio-pharmaceuticals according to claim 1, is characterized in that: welding embedded central processing unit on a printed circuit board and holder are bi-directionally connected.
5. a kind of electromagnetic agitation separator for bio-pharmaceuticals according to claim 1, is characterized in that: described pressure sensor is a kind of diffuse silicon formula pressure sensor.
6. a kind of electromagnetic agitation separator for bio-pharmaceuticals according to claim 1, is characterized in that: described battery and LOAD CELLS, pressure sensor, A/D converter, embedded central processing unit, holder and D/A converter are electrically connected.
CN201510965358.2A 2015-12-21 2015-12-21 A kind of electromagnetic agitation separator for bio-pharmaceuticals Expired - Fee Related CN105396499B (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105967268A (en) * 2016-05-23 2016-09-28 中山市捷信科技服务有限公司 A visible light catalytic sewage treatment equipment
CN106241565A (en) * 2016-08-24 2016-12-21 宁夏通宇电梯制造发展股份有限公司 Between a kind of sightseeing elevator and preparation method thereof

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CN102879057A (en) * 2012-10-12 2013-01-16 龙岩烟草工业有限责任公司 Charging bucket liquid level measuring device and method as well as dispensing equipment
CN202893269U (en) * 2012-11-22 2013-04-24 北大荒丰缘集团有限公司 Magnetic stirrer
CN103071418A (en) * 2013-01-23 2013-05-01 辽宁石油化工大学 Suspended magnetic stirrer
CN103837272A (en) * 2012-11-27 2014-06-04 Ge医疗系统环球技术有限公司 Curved-surface film pressure sensor and manufacturing method thereof
CN104645863A (en) * 2013-11-25 2015-05-27 西安华雍机电科技有限公司 Magnetic stirrer with weighing function

Patent Citations (5)

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Publication number Priority date Publication date Assignee Title
CN102879057A (en) * 2012-10-12 2013-01-16 龙岩烟草工业有限责任公司 Charging bucket liquid level measuring device and method as well as dispensing equipment
CN202893269U (en) * 2012-11-22 2013-04-24 北大荒丰缘集团有限公司 Magnetic stirrer
CN103837272A (en) * 2012-11-27 2014-06-04 Ge医疗系统环球技术有限公司 Curved-surface film pressure sensor and manufacturing method thereof
CN103071418A (en) * 2013-01-23 2013-05-01 辽宁石油化工大学 Suspended magnetic stirrer
CN104645863A (en) * 2013-11-25 2015-05-27 西安华雍机电科技有限公司 Magnetic stirrer with weighing function

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105967268A (en) * 2016-05-23 2016-09-28 中山市捷信科技服务有限公司 A visible light catalytic sewage treatment equipment
CN105967268B (en) * 2016-05-23 2019-01-22 中山市捷信科技服务有限公司 Visible light catalysis sewage treatment device
CN106241565A (en) * 2016-08-24 2016-12-21 宁夏通宇电梯制造发展股份有限公司 Between a kind of sightseeing elevator and preparation method thereof

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Effective date of registration: 20191213

Address after: 276100 Renhe Road 1, town home appliance industrial park, Li Town, Linyi, Shandong, Tancheng

Patentee after: SHANDONG RENHE PHARMACEUTICAL Co.,Ltd.

Address before: 528437, Guangdong Industrial Zone, Zhongshan City Torch Development Zone, Hong Kong Road, creative industrial park, No. 3 business card 501

Patentee before: ZHONGSHAN HOUYUAN ELECTRONICS TECHNOLOGY Co.,Ltd.

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Granted publication date: 20171107

Termination date: 20211221