CN105395516A - Fuyuekang capsule and preparation method thereof - Google Patents
Fuyuekang capsule and preparation method thereof Download PDFInfo
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- CN105395516A CN105395516A CN201510898730.2A CN201510898730A CN105395516A CN 105395516 A CN105395516 A CN 105395516A CN 201510898730 A CN201510898730 A CN 201510898730A CN 105395516 A CN105395516 A CN 105395516A
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- 238000002360 preparation method Methods 0.000 title claims abstract description 9
- 239000002775 capsule Substances 0.000 title abstract 4
- 238000001035 drying Methods 0.000 claims abstract description 16
- 238000000034 method Methods 0.000 claims abstract description 9
- 238000000227 grinding Methods 0.000 claims abstract description 8
- 238000000194 supercritical-fluid extraction Methods 0.000 claims abstract description 8
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 28
- 239000006071 cream Substances 0.000 claims description 21
- 239000000843 powder Substances 0.000 claims description 21
- 210000000582 semen Anatomy 0.000 claims description 18
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 14
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 14
- 239000001569 carbon dioxide Substances 0.000 claims description 14
- 238000002156 mixing Methods 0.000 claims description 14
- 241000628997 Flos Species 0.000 claims description 9
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 8
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 8
- 229930195725 Mannitol Natural products 0.000 claims description 8
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 8
- 229920002472 Starch Polymers 0.000 claims description 8
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 8
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 8
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims description 8
- 238000004132 cross linking Methods 0.000 claims description 8
- 235000019359 magnesium stearate Nutrition 0.000 claims description 8
- 239000000594 mannitol Substances 0.000 claims description 8
- 235000010355 mannitol Nutrition 0.000 claims description 8
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 8
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 8
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 8
- 239000011734 sodium Substances 0.000 claims description 8
- 229910052708 sodium Inorganic materials 0.000 claims description 8
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 8
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 8
- 239000008107 starch Substances 0.000 claims description 8
- 235000019698 starch Nutrition 0.000 claims description 8
- 206010013786 Dry skin Diseases 0.000 claims description 7
- 238000000605 extraction Methods 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 7
- 239000002245 particle Substances 0.000 claims description 7
- 238000005550 wet granulation Methods 0.000 claims description 7
- 210000001015 abdomen Anatomy 0.000 claims description 5
- 239000003433 contraceptive agent Substances 0.000 claims description 5
- 230000002254 contraceptive effect Effects 0.000 claims description 5
- 201000010099 disease Diseases 0.000 claims description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 5
- 239000003814 drug Substances 0.000 claims description 5
- 230000000694 effects Effects 0.000 abstract description 6
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 abstract description 3
- 244000144730 Amygdalus persica Species 0.000 abstract description 2
- 241000308663 Eupatorium fortunei Species 0.000 abstract description 2
- 244000270834 Myristica fragrans Species 0.000 abstract description 2
- 235000009421 Myristica fragrans Nutrition 0.000 abstract description 2
- 241000213006 Angelica dahurica Species 0.000 abstract 1
- 244000020518 Carthamus tinctorius Species 0.000 abstract 1
- 235000003255 Carthamus tinctorius Nutrition 0.000 abstract 1
- 240000007890 Leonurus cardiaca Species 0.000 abstract 1
- 235000000802 Leonurus cardiaca ssp. villosus Nutrition 0.000 abstract 1
- 241000112528 Ligusticum striatum Species 0.000 abstract 1
- 235000006040 Prunus persica var persica Nutrition 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 description 5
- 208000007106 menorrhagia Diseases 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 230000010354 integration Effects 0.000 description 3
- 235000008495 Chrysanthemum leucanthemum Nutrition 0.000 description 2
- 244000192528 Chrysanthemum parthenium Species 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 235000008384 feverfew Nutrition 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 235000011446 Amygdalus persica Nutrition 0.000 description 1
- 241000382455 Angelica sinensis Species 0.000 description 1
- 241000125183 Crithmum maritimum Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000134253 Lanka Species 0.000 description 1
- 240000003271 Leonurus japonicus Species 0.000 description 1
- 241001081833 Myristicaceae Species 0.000 description 1
- 240000002381 Prunus davidiana Species 0.000 description 1
- 235000013527 bean curd Nutrition 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000006837 decompression Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 230000004345 fruit ripening Effects 0.000 description 1
- 230000003760 hair shine Effects 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/533—Leonurus (motherwort)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
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- Medical Informatics (AREA)
- Microbiology (AREA)
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- Medicines Containing Plant Substances (AREA)
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Abstract
The invention discloses a fuyuekang capsule and a preparation method thereof. The method is characterized by comprising: subjecting 72g of myristica fragrans, 14.4g of Eupatorium fortunei, 216g of Chinese angelica, 72g of Ligusticum wallichii, 36g of peach kernel, 288g of motherwort and 14.4g of safflower to CO2 supercritical extraction, conducting pressure reduction drying, grinding the product into nano dry paste with high-energy nano impact mill, and adding functional auxiliary materials to prepare the fuyuekang capsule. The disintegration time is significantly shortened, the curative effect is remarkably superior to that of commercially available fuyuekang capsules, and positive results can be achieved.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of MCH information system and preparation method thereof.
Background technology
MCH information system is invigorated blood circulation, blood stasis dispelling, pain relieving.For disease that postpartum lochia can't go, few abdomen pain, also can try out the colporrhagia caused after being fitted with a contraceptive ring, menorrhagia.Commercially available MCH information system is due to prescription and technological reason, and curative effect is not satisfactory, and preparation adopts traditional handicraft preparation, there is the deficiencies such as prolonged disintegration, curative effect are low.
Summary of the invention
The present invention, for overcoming above-mentioned deficiency, provides MCH information system that a kind of disintegration rate is fast, curative effect is high and preparation method thereof.
Invention embodiment is as follows:
Get Semen Myristicae 72g, Herba Eupatorii 14.4g, Radix Angelicae Sinensis 216g, Rhizoma Chuanxiong 72g, Semen Persicae 36g, Herba Leonuri 288g, Flos Carthami 14.4g, is ground into 60 order coarse powder, adopts carbon dioxide supercritical extraction method to extract, extracting pressure 22 ~ 35Mpa, extraction temperature 25 ~ 40 DEG C, separator pressure 10 ~ 20Mpa, separator temperature 44 ~ 55 DEG C, disengaging time 2.6 ~ 3.9 hours, carbon dioxide flow 24 ~ 38L per hour, obtains extracting solution; Get extracting solution 61 ~ 79 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add mannitol 150 ~ 200g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 45 ~ 55g, crospolyvinylpyrrolidone 45 ~ 55g, cross-linking sodium carboxymethyl cellulose 35 ~ 45g, mix homogeneously, with 50 ~ 70% ethanol wet granulations, 60 DEG C ~ 80 DEG C dryings, additional carboxymethyl starch sodium 7 ~ 9g, magnesium stearate 1 ~ 3g, granulate, incapsulates, obtained MCH information system 1200.
The raw material standards that above-mentioned embodiment is mentioned is as follows:
Semen Myristicae: China's coastal port one ministerial standard.This product has another name called Fructus Amomi Rotundus, flesh fruit, semen myristicae.For the kernel of myristicaceae plant Semen Myristicae MyristicafragransHoutt.Main product is in states such as Malaysia, Indonesia, Sri Lanka, and torrid areas is extensively cultivated.There is introducing and planting on the ground such as China Taiwan, Guangdong, Yunnan.Summer harvesting ripe fruit, removing peel, peel off aril, low temperature is slowly dried.
Herba Eupatorii: China's coastal port one ministerial standard.This product is the dry aerial parts of feverfew Herba Eupatorii EupatoriumfortuneiTurcz..Summer, Qiu Erji tap at twice, and removing impurity, dries.
Radix Angelicae Sinensis: China's coastal port one ministerial standard.This product is umbelliferae angelica Angelicasinensis(Oliv.) dry root of Diels.Autumn end excavates, and removing fibrous root and silt, after moisture slightly evaporates, be bundled into wisp, upper canopy, with pyrotechnics slowly smoke-dried beancurd.
Rhizoma Chuanxiong: China's coastal port one ministerial standard.This product is the dry rhizome of samphire Rhizoma Chuanxiong LigusticumchuanriongHort..The joint dish that summer works as on stem is significantly outstanding, and excavates during purplish, and removing silt, shines post-drying, then remove fibrous root.
Semen Persicae: China's coastal port one ministerial standard.This product is rosaceous plant Fructus Persicae Prunuspersica(L.) Batsch or Prunus davidiana Prunusdavidiana(Cars.) dry mature seed of Franch..Gather after fruit maturation, removing sarcocarp and nucleocapsid, take out seed, dry.
Herba Leonuri: China's coastal port one ministerial standard.This product is the fresh or dry aerial parts of labiate Herba Leonuri LeonurusjaponicusHoutt..Fresh goods Seedling Stage in spring is tapped to first summer flower early stage; Dry product stem and leaf in summer is luxuriant, HUAMU is opened or tap when just opening, and dry, or cutting is dried.
Flos Carthami: China's coastal port one ministerial standard.This product is the dried floral of feverfew Flos Carthami CarthamustinctoriusL..Pluck when summer, flower was red by xanthochromia, dry in the shade or dry.
Mannitol: Chinese Pharmacopoeia version two ministerial standard in 2010.
Microcrystalline Cellulose: Chinese Pharmacopoeia version two ministerial standard in 2010.
Crospolyvinylpyrrolidone: Chinese Pharmacopoeia version two ministerial standard in 2010.
Cross-linking sodium carboxymethyl cellulose: Chinese Pharmacopoeia version two ministerial standard in 2010.
Carboxymethyl starch sodium: Chinese Pharmacopoeia version two ministerial standard in 2010.
Magnesium stearate: Chinese Pharmacopoeia version two ministerial standard in 2010.
Raw material used by above MCH information system all can be bought from pharmaceuticals and obtain, and all can be used to implement the present invention program as long as meet national standard.
In foregoing invention scheme, term used is pharmacy proprietary term, as " decompression " etc. all defers to Chinese Pharmacopoeia regulation and pharmaceutical practice of being correlated with.
Unit g in the present invention also can be other weight portion, does not affect the enforcement of the present invention program.
Equipment Market described in the present invention program all has sale, is not limited to typical production producer, as long as technical specification can reach requirement, all can be used to realize the present invention.
Four detailed description of the invention
Specific embodiments of the invention 1
Get Semen Myristicae 72g, Herba Eupatorii 14.4g, Radix Angelicae Sinensis 216g, Rhizoma Chuanxiong 72g, Semen Persicae 36g, Herba Leonuri 288g, Flos Carthami 14.4g, is ground into 60 order coarse powder, adopts carbon dioxide supercritical extraction method to extract, extracting pressure 22Mpa, extraction temperature 25 DEG C, separator pressure 10Mpa, separator temperature 44 DEG C, disengaging time 2.6 hours, carbon dioxide flow 24L per hour, obtains extracting solution; Get extracting solution 61 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add mannitol 150g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 45g, crospolyvinylpyrrolidone 45g, cross-linking sodium carboxymethyl cellulose 35g, mix homogeneously, with 50% ethanol wet granulation, 60 DEG C of dryings, additional carboxymethyl starch sodium 7g, magnesium stearate 1g, granulate, incapsulates, obtained MCH information system 1200.
Specific embodiments of the invention 2
Get Semen Myristicae 72g, Herba Eupatorii 14.4g, Radix Angelicae Sinensis 216g, Rhizoma Chuanxiong 72g, Semen Persicae 36g, Herba Leonuri 288g, Flos Carthami 14.4g, is ground into 60 order coarse powder, adopts carbon dioxide supercritical extraction method to extract, extracting pressure 35Mpa, extraction temperature 40 DEG C, separator pressure 20Mpa, separator temperature 55 DEG C, disengaging time 3.9 hours, carbon dioxide flow 38L per hour, obtains extracting solution; Get extracting solution 79 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add mannitol 200g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 55g, crospolyvinylpyrrolidone 55g, cross-linking sodium carboxymethyl cellulose 45g, mix homogeneously, with 70% ethanol wet granulation, 80 DEG C of dryings, additional carboxymethyl starch sodium 9g, magnesium stearate 3g, granulate, incapsulates, obtained MCH information system 1200.
Specific embodiments of the invention 3
Get Semen Myristicae 72g, Herba Eupatorii 14.4g, Radix Angelicae Sinensis 216g, Rhizoma Chuanxiong 72g, Semen Persicae 36g, Herba Leonuri 288g, Flos Carthami 14.4g, is ground into 60 order coarse powder, adopts carbon dioxide supercritical extraction method to extract, extracting pressure 28Mpa, extraction temperature 33 DEG C, separator pressure 15Mpa, separator temperature 50 DEG C, disengaging time 3.3 hours, carbon dioxide flow 31L per hour, obtains extracting solution; Get extracting solution 70 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add mannitol 175g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 50g, crospolyvinylpyrrolidone 50g, cross-linking sodium carboxymethyl cellulose 40g, mix homogeneously, with 60% ethanol wet granulation, 70 DEG C of dryings, additional carboxymethyl starch sodium 8g, magnesium stearate 2g, granulate, incapsulates, obtained MCH information system 1200.
Above embodiment illustrates, adopts the extreme condition of embodiment of the present invention and optimal conditions all can make MCH information system.Actual effect of the present invention is investigated below with the MCH information system that embodiment 3 is obtained:
(1) embodiment 3 MCH information system and contrast disintegration of commercially available MCH information system
1 disintegration time mensuration method
Measure by Chinese Pharmacopoeia version annex Ⅻ A in 2010.
Contrast 2 disintegrations
Table 1 embodiment 3 MCH information system and commercially available MCH information system contrast table disintegration
The above results shows, MCH information system prepared by the present invention has the remarkable advantages such as disintegration rate is fast, bioavailability is high relative to commercially available MCH information system.
(2) embodiment 3 MCH information system and the few abdomen pain of commercially available MCH information system treatment disease that postpartum lochia can't go, be fitted with a contraceptive ring after cause colporrhagia, menorrhagia clinical observation on the therapeutic effect
1 case scenario
Statistics outpatient service and inpatient, observe the few abdomen pain of disease that postpartum lochia can't go altogether, be fitted with a contraceptive ring after cause colporrhagia, menorrhagia case 135 example, 33 years old mean age.Patient is divided into two groups, test group takes embodiment 3 MCH information system, and matched group takes commercially available MCH information system.
2 efficacy assessment standards
According to new Chinese medicine treatment guideline of clinical investigations tcm syndrome curative effect determinate standard:
Clinical recovery: tcm clinical practice symptom, sign disappear or substantially disappear, syndrome integral reduces >=95%.
Effective: tcm clinical practice symptom, sign are obviously improved, syndrome integral reduces >=70%.
Effective: tcm clinical practice symptom, sign all take a favorable turn, syndrome integral reduces >=30%.
Invalid: tcm clinical practice symptom, sign are all not improved or increase the weight of, syndrome integral reduces < 30%.
Computing formula: [before (before treatment the rear integration of integration-treatment) ÷ treatment integration] × 100%.
3 clinical observation result
Table 2 embodiment 3 MCH information system and commercially available MCH information system clinical efficacy contrast table
Above-mentioned clinical observation on the therapeutic effect result shows, when the colporrhagia that MCH information system prepared by the present invention causes after treating the few abdomen pain of disease that postpartum lochia can't go, being fitted with a contraceptive ring, menorrhagia, evident in efficacy higher than commercially available MCH information system, p < 0.05.
Claims (3)
1. one kind treat the few abdomen pain of disease that postpartum lochia can't go, be fitted with a contraceptive ring after cause colporrhagia, menorrheal Chinese medicine, it is characterized in that getting Semen Myristicae 72g, Herba Eupatorii 14.4g, Radix Angelicae Sinensis 216g, Rhizoma Chuanxiong 72g, Semen Persicae 36g, Herba Leonuri 288g, Flos Carthami 14.4g, be ground into 60 order coarse powder, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 22 ~ 35Mpa, extraction temperature 25 ~ 40 DEG C, separator pressure 10 ~ 20Mpa, separator temperature 44 ~ 55 DEG C, disengaging time 2.6 ~ 3.9 hours, carbon dioxide flow 24 ~ 38L per hour, obtains extracting solution; Get extracting solution 61 ~ 79 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add mannitol 150 ~ 200g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 45 ~ 55g, crospolyvinylpyrrolidone 45 ~ 55g, cross-linking sodium carboxymethyl cellulose 35 ~ 45g, mix homogeneously, with 50 ~ 70% ethanol wet granulations, 60 DEG C ~ 80 DEG C dryings, additional carboxymethyl starch sodium 7 ~ 9g, magnesium stearate 1 ~ 3g, granulate, incapsulates, obtained MCH information system.
2. the preparation method of Chinese medicine according to claim 1, is characterized in that getting Semen Myristicae 72g, Herba Eupatorii 14.4g, Radix Angelicae Sinensis 216g, Rhizoma Chuanxiong 72g, Semen Persicae 36g, Herba Leonuri 288g, Flos Carthami 14.4g, be ground into 60 order coarse powder, employing carbon dioxide supercritical extraction method is extracted, extracting pressure 22 ~ 35Mpa, extraction temperature 25 ~ 40 DEG C, separator pressure 10 ~ 20Mpa, separator temperature 44 ~ 55 DEG C, disengaging time 2.6 ~ 3.9 hours, carbon dioxide flow 24 ~ 38L per hour, obtains extracting solution; Get extracting solution 61 ~ 79 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add mannitol 150 ~ 200g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 45 ~ 55g, crospolyvinylpyrrolidone 45 ~ 55g, cross-linking sodium carboxymethyl cellulose 35 ~ 45g, mix homogeneously, with 50 ~ 70% ethanol wet granulations, 60 DEG C ~ 80 DEG C dryings, additional carboxymethyl starch sodium 7 ~ 9g, magnesium stearate 1 ~ 3g, granulate, incapsulates, obtained MCH information system.
3. the preparation method of Chinese medicine according to claim 1, gets Semen Myristicae 72g, Herba Eupatorii 14.4g, Radix Angelicae Sinensis 216g, Rhizoma Chuanxiong 72g, Semen Persicae 36g, Herba Leonuri 288g, Flos Carthami 14.4g, be ground into 60 order coarse powder, employing carbon dioxide supercritical extraction method is extracted, extracting pressure 28Mpa, extraction temperature 33 DEG C, separator pressure 15Mpa, separator temperature 50 DEG C, disengaging time 3.3 hours, carbon dioxide flow 31L per hour, obtains extracting solution; Get extracting solution 70 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add mannitol 175g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 50g, crospolyvinylpyrrolidone 50g, cross-linking sodium carboxymethyl cellulose 40g, mix homogeneously, with 60% ethanol wet granulation, 70 DEG C of dryings, additional carboxymethyl starch sodium 8g, magnesium stearate 2g, granulate, incapsulates, obtained MCH information system.
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Application publication date: 20160316 |