CN105360136A - Sterilization composition containing mepanipyrim and diniconazole and application thereof - Google Patents

Sterilization composition containing mepanipyrim and diniconazole and application thereof Download PDF

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CN105360136A
CN105360136A CN201510751885.3A CN201510751885A CN105360136A CN 105360136 A CN105360136 A CN 105360136A CN 201510751885 A CN201510751885 A CN 201510751885A CN 105360136 A CN105360136 A CN 105360136A
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diniconazole
mepanipyrim
control
sterilization composition
composition
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CN201510751885.3A
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赵东亚
彭永强
郭崇友
白杰
程清云
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南京华洲药业有限公司
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Abstract

The invention discloses a sterilization composition containing mepanipyrim and diniconazole and application thereof. The sterilization composition employs mepanipyrim and diniconazole as the main effective compositions, and the mass ratio of mepanipyrim to diniconazole is 1-70:1-50. The sterilization composition is applicable to control diseases of cereals, fruit trees and vegetables, possesses relatively high synergic interaction, overcomes and delays pathogen drug resistance, is fast in sterilization speed and long in lasting period, helps to reduce application cost, and possesses the control effect obviously better than the singly-used compositions. The sterilization composition is applicable to control fungi diseases of crops, especially applicable to control powdery mildew, botrytis blight, brown rot, smut disease, rust and other fungi diseases, and possesses the effect better than that of the single-used compositions.

Description

一种含嘧菌胺和烯唑醇的杀菌组合物及其应用 Fungicidal compositions containing mepanipyrim and Its Application diniconazole

技术领域: FIELD:

[0001] 本发明涉及一种杀菌组合物及其用途,尤其是一种以嘧菌胺和烯唑醇为主要活性成分的杀菌组合物及其应用。 [0001] The present invention relates to a fungicidal composition and its use, in particular, is a kind of mepanipyrim and diniconazole germicidal compositions and the use of the main active ingredient.

背景技术 Background technique

[0002] 嘧菌胺(Mepanioyrim),化学名称:4-甲基-N-苯基-6-(1-丙炔基)-2-嘧啶胺, 分子式:c14h13n3。 [0002] mepanipyrim (Mepanioyrim), chemical name: 4-Methyl -N- phenyl-6- (1-propynyl) -2-pyrimidinamine, of the formula: c14h13n3. 结构式如下: Structural formula:

[0003] [0003]

Figure CN105360136AD00031

[0004] 作用机理:嘧菌胺具有独特的作用机理即抑制病原菌蛋白质分泌,包括降低一些水解酶水平,据推测这些酶与病原菌进人寄主植物并引起寄主组织的坏死有关。 [0004] The mechanism of action: mepanipyrim has a unique mechanism of action which inhibits protein secretion pathogens, including reducing the number of levels of hydrolytic enzymes, these enzymes presumably host plant and pathogen into the host tissue, and cause necrosis concerned. 主要防治防治苹果和梨黑星病,黄瓜、葡萄、草莓和番茄灰霉病,桃、梨等褐腐病等。 The main prevention and control of apple scab, cucumber, grape, strawberry and tomato gray mold, peach, pear and other brown rot disease. 甲基嘧菌胺同三唑类、二硫代氨基甲酸酯类、苯并咪唑类及乙霉威等无交互抗性,因此其对敏感或抗性病原菌均有优异的活性。 Methyl mepanipyrim with triazoles, dithiocarbamates, benzimidazoles and diethofencarb no cross-resistance and the like, and therefore their excellent activity against pathogenic bacteria are sensitive or resistant.

[0005]烯唑醇(Diniconazole),分子式:C15H17C12N30 化学名称:(E)-(RS)-1-(2,4-二氯苯基)-4,4-二甲基-2-(1H-1,2,4_三唑-1-基)戊-1烯-3-醇。 [0005] diniconazole (Diniconazole), molecular formula: C15H17C12N30 Chemical Name: (E) - (RS) -1- (2,4- dichlorophenyl) -4,4-dimethyl -2- (1H- 1,2,4_ triazol-1-yl) pent -1-en-3-ol. 结构式: Structure:

[0006] [0006]

Figure CN105360136AD00032

[0007]烯唑醇属三唑类杀菌剂,在真菌的麦角甾醇生物合成中抑制14α-脱甲基化作用,引起麦角留醇缺乏,导致真菌细胞膜不正常,最终真菌死亡,持效期长久。 [0007] diniconazole a triazole fungicide, 14α- demethylation inhibiting the biosynthesis of ergosterol in fungi, causing a lack of alcohol ergot left, resulting in abnormal fungal cell membrane, ultimately death fungi, long persistence . 是一种具有保护、治疗、铲除作用的广谱性杀菌剂;对于囊菌、担子菌引起的多种植物病害如白粉病、锈病、黑粉病、黑星病等有特效。 It is a protective, therapeutic, effect of broad spectrum fungicide eradication; bacteria to the bladder, various plant diseases caused by Basidiomycetes, such as powdery mildew, rust, smut, scab are special effects. 另外,还对尾孢霉、球腔菌、核盘菌、菌核菌、丝核菌引起的病害有良效。 In addition, good effect of disease Cercospora sp, Leptosphaeria, Sclerotinia sclerotiorum, Sclerotinia, Rhizoctonia caused.

[0008]目前植物病菌的防治难度越来越大,一方面,随着种植结构的改变,瓜果、蔬菜等经济作物种植面积逐步扩大,病害发生程度、发生数量均有所提高,在防治上难度加大;另一方面,病原菌的抗性在持续的药剂选择压力下逐年上升,单剂的防治效果大打折扣,植物病害防治面临着重大挑战。 [0008] currently difficult to control plant pathogens is increasing, on the one hand, with the change of planting structure, fruits, vegetables and other cash crops planting area gradually expanded, the degree of disease occurrence, the number of occurrences were higher in the prevention and treatment more difficult; on the other hand, resistance to pathogens increased year by year in the ongoing drug selection pressure, control effect of a single dose greatly reduced, plant disease control faces significant challenges.

发明内容: SUMMARY:

[0009]本发明的目的是针对上述技术问题提供一种适用范围广、成本低、效果好的含嘧菌胺与烯唑醇的植物杀菌组合物。 [0009] The object of the present invention is to provide a wide application range, low cost, good effect and containing mepanipyrim diniconazole address the above technical problem plant fungicidal composition.

[0010] 本发明还有一个目的是提供该杀菌组合物在防治植物真菌引起真菌病害上的应用,尤其是在防治白粉病、灰霉病、褐腐病、黑粉病、锈病等真菌病害上的用途。 [0010] Another object of the present invention to provide a germicidal composition for use in the control of plant fungal diseases caused by fungi, especially in the prevention and treatment of powdery mildew, gray mold, brown rot, smut, rust and other fungal diseases the use of.

[0011] 本发明的目的是通过以下技术方案实现: [0011] The object of the present invention is achieved by the following technical solution:

[0012] -种含嘧菌胺和烯唑醇的杀菌组合物,该杀菌组合物以嘧菌胺与烯唑醇为主要有效成分,其中嘧菌胺与烯唑醇的质量比为1~70 :1~50,其中杀菌组合物中有效成份以增效有效量存在于组合物中。 [0012] - seed disinfectant composition containing mepanipyrim and diniconazole of the germicidal composition to mepanipyrim and diniconazole as the main active ingredient, wherein the mass ratio of mepanipyrim and diniconazole 1 to 70 : 1 to 50, wherein the germicidal composition in a synergistically effective amount of the active ingredient present in the composition.

[0013] 所述的杀菌组合物,其中嘧菌胺与烯唑醇的质量比优选为1~50 :1~50,进一步优选为1~10 :1~10 ;最优选为1~5 :1~4 ;特别优选为5 :1。 [0013] The fungicidal composition, wherein the mass of mepanipyrim and diniconazole is preferably from 1 to about 50: 1 to 50, more preferably from 1 to 10: 1 to 10; most preferably 1 to 5: 1 to 4; particularly preferably 5: 1.

[0014] 在本发明组合物中,嘧菌胺和烯唑醇二者占组合物的质量百分含量为2~80%。 [0014] In the compositions of the present invention, both the mepanipyrim and diniconazole account the mass percentage composition is 2 to 80%. 优选10~40%。 Preferably 10 to 40%.

[0015] 所述的杀菌组合物,其中以嘧菌胺和烯唑醇为主要有效成分与已知的助剂和赋形剂复配成农药上允许的任意一种剂型。 [0015] The fungicidal composition, which mepanipyrim and diniconazole as the main active ingredient is mixed with any of known adjuvants and excipients formulated into a dosage form pesticide allowed. 这些已知的助剂、赋型剂有分散剂、扩散剂、消泡剂、 润湿剂、崩解剂等,可以采用十二烷基苯磺酸钙、烷基酚聚氧乙烯醚、苄基酚聚氧乙烯醚、苯乙基酚聚氧乙烯醚、脂肪醇聚氧乙烯醚及其类似产品、脂肪胺聚氧乙烯醚、脂肪酸环氧乙烷加成物、聚氧乙烯聚氧丙稀嵌段化合物、蓖麻油聚氧乙烯醚、壬基酚聚氧乙烯醚、吐温系列、 脂肪醇聚氧乙烯醚、聚乙二醇系列、磺酸盐类、羧酸盐、硫酸盐、磷酸盐、亚磷酸盐、木质素磺酸盐、黄原胶、酚甲醛缩合物、铵盐、季铵盐型等中的一个或多个组合,赋形剂包括环己酮、 二甲苯、各种溶剂油、水、防冻剂(如丙二醇)、去离子水等。 These known adjuvants, excipients dispersant, spreading agents, defoamers, wetting agents, disintegrating agents and the like may be employed calcium dodecylbenzene sulfonate, polyoxyethylene alkylphenol ether, benzyl phenol polyoxyethylene ether, phenethyl phenol polyoxyethylene ether, fatty alcohol polyoxyethylene ethers and similar products, polyoxyethylene fatty amine, fatty acid ethylene oxide adducts, polyoxyethylene polyoxypropylene block compound, polyoxyethylene castor oil, polyoxyethylene nonylphenyl ether, Tween series, polyoxyethylene fatty alcohol ethers, polyethylene glycol series, sulfonates, carboxylates, sulfates, phosphates , a combination of one or more phosphites, lignosulfonates, xanthan gum, phenol formaldehyde condensates, ammonium, quaternary ammonium and the like, excipients include cyclohexanone, xylene, various solvents oil, water, antifreeze (e.g., propylene glycol), deionized water and the like. 以上助剂、赋形剂及其它辅料可以单用或并用。 Or more adjuvants, excipients and other materials can be used alone or in combination.

[0016] 所述的杀菌组合物,其剂型是乳油、可湿性粉剂、悬浮剂、水乳剂、微乳剂或水分散颗粒剂。 [0016] The fungicidal composition, which dosage forms are emulsifiable concentrates, wettable powders, suspensions, water emulsions or water-dispersible granules.

[0017] 上述的杀菌组合物在制备防治植物真菌病害药物上的应用。 Applications [0017] The fungicidal compositions in the preparation of a medicament for controlling plant fungal diseases. 尤其是在防治禾谷类、果树、蔬菜作物病害方面的应用。 Especially in terms of the application against cereal, fruit, vegetable crop diseases.

[0018] 上述的应用,所述的植物真菌病害为白粉病、灰霉病、褐腐病、黑粉病、锈病中的至少一种。 [0018] The application of the plant fungal diseases as powdery mildew, gray mold, brown rot, smut, at least one of rust.

[0019] 本发明的有益效果: [0019] Advantageous effects of the invention:

[0020] 1、本发明所用的嘧菌胺和烯唑醇,作用机理不同,相互混配不会产生抵触,可协同增效,减少用药量,降低成本。 [0020] 1, mepanipyrim used in the present invention and diniconazole, different mechanisms of action, will not conflict with each other compounding can be synergistic, reducing the dosage, and reduce costs.

[0021] 2、本发明组合物适用范围增加,适用于防治禾谷类、果树、蔬菜的抗性真菌病害, 特别是防治白粉病、灰霉病、褐腐病、黑粉病、锈病等均有显著的效果。 [0021] 2. The composition of the present invention is to increase the scope of application, suitable for controlling cereal, fruit trees, vegetables, fungal disease resistance, in particular for controlling powdery mildew, gray mold, brown rot, smut, rust, etc. are significant effect. 本发明杀菌组合物对子囊菌、担子菌、半知菌和卵菌纲真菌病害具有很好的防治效果;并抑制害虫或真菌对单一制剂(嘧菌胺和烯唑醇任一)的抗药性的产生。 The fungicidal compositions according to the invention Ascomycetes, Basidiomycetes, Deuteromycetes and Oomycetes fungi diseases have a good control effect; and inhibiting fungal resistance to a pest or a single formulation (mepanipyrim and diniconazole any one) of generation. 本发明杀菌组合物能产生较高的协同增效作用,并且该混合物的用量比单独活性化合物的用量大大降低,即混合物的活性大于单独组分的活性。 Fungicidal compositions of the present invention can produce a high synergistic effect, and with the ratio of the amount of the individual active compound mixture is greatly reduced, i.e., the activity of the mixture is greater than the activity of the individual components.

[0022] 与现有技术相比本发明的有益效果:(1)与单剂相比,该组合物对抗性真菌病害如白粉病、灰霉病、褐腐病、黑粉病、锈病等真菌病害有明显协同增效作用,克服和延缓了抗药性,扩大防治谱,明显提高了防治效果;(2)减少防治用工、用药成本;(3)可替代常规和易产生抗性的农药;(4)与单剂相比,生产和使用成本降低;(5)抑制真菌抗药性的产生,其效果明显高于其单剂使用。 [0022] Advantageous effects of the present invention compared with the prior art: (1) Compared with the single dose, the composition antagonistic to fungal diseases such as powdery mildew, gray mold, brown rot, smut, rust and other fungi diseases are significant synergies to overcome drug resistance and delaying, expansion control spectrum, significantly improve the control effect; (2) prevention of labor reduction, the cost of medication; (3) an alternative conventional pesticide resistant and easy to produce; ( 4) compared to the single dose, and use of the production costs; (5) inhibits the production of resistance, which is significantly higher than the effect of a single agent.

具体实施方式 Detailed ways

[0023] 以下结合实施例对本发明作进一步说明,实施例中剂型的制备方法均为常规方法,本发明所述的" % "均为质量百分比。 [0023] The following embodiments in conjunction with the present invention will be further described, in a dosage form prepared according to a conventional method are embodiments of the present invention, "%" are percent by mass.

[0024] 室内生测试验: [0024] indoor bioassay test:

[0025] 在室内采用菌丝生长速率法,测定不同药剂对菌株的EC5。 [0025] The mycelial growth rate in the chamber, for measuring different agents EC5 strain. 值,采用共毒系数计算方法,计算出混剂的共毒系数(CTC),确定混剂的增效性,具体计算方法如下: Value, using the co-toxicity coefficient calculation method, the co-toxicity coefficient (CTC) Mixture determining synergistic mixture by the specific calculation is as follows:

[0026] 以混剂中某一单剂为标准药剂(通常选择EC5。较低者),进行计算: [0026] (usually selecting the lower of EC5), to calculate a single dose in mixture of standard agents:

[0027] 单剂毒力指数=标准药剂EC5。 [0027] The single dose toxicity index = standard agents EC5. /某单剂ECMX100 / A single dose ECMX100

[0028] 理论毒力指数=A单剂的毒力指数XA单剂在混剂中所占比例+B单剂的毒力指数XB单剂在混剂中所占比例 [0028] Theoretical toxicity index = index XA single dose toxicity A single dose proportion XB + Toxicity index of a single dose of a single agent B in mixture in a proportion in the mixed agent

[0029] 实测毒力指数=标准单剂的EC5。 [0029] EC5 Found toxicity index = standard single agent. 值/混剂的EC5。 Value / Mixture of EC5. 值X100 Value X100

[0030] 共毒系数=实测毒力指数/理论毒力指数X100 [0030] Co-toxicity coefficient = virulence index Found / Theoretical toxicity index X100

[0031] 共毒系数分级:CTC大于120时混剂具有协同增效性,CTC小于80时为拮抗,CTC 在80-120之间为相加作用。 [0031] toxicity coefficient Rating: When greater than 120 CTC compounding agents having synergistic properties, CTC antagonistic less than 80, CTC additive effect between 80-120.

[0032] 按照有效成分嘧菌胺(A):烯唑醇⑶质量配比为70 :1、50 :1、30 :1、20 :1、10 :1、 5 :1、2· 5 :1、1 :1、1 :2、1 :4、1 :6、1 :10、1 :20、1 :30、1 :50 进行试验,测定其对黄瓜灰霉病菌(bocrytisCinereaPers.)的共毒系数。 [0032] The active ingredients according to mepanipyrim (A): diniconazole ⑶ mass ratio of 70: 1, 50: 1, 30: 1, 20: 1, 10: 1, 5: 1, 5.5: 1 , 1: 1,1: 2,1: 4,1: 6,1: 10,1: 20, 1: 30, 1: 50 were tested for toxicity coefficient measured Botrytis cinerea (bocrytisCinereaPers.) of .

[0033] 表1 :嘧菌胺+烯唑醇不同配比对黄瓜灰霉病菌的室内生测结果 [0033] Table 1: mepanipyrim + diniconazole different ratio bioassay results of Botrytis cinerea

[0034] [0034]

Figure CN105360136AD00051

Figure CN105360136AD00061

[0035] 此外,发明人经研究发现当A:B的数值大于70或者A:B的数值小于1:50,此时二组分配合使用是没有协同效应的,且经计算共毒系数均小于120。 [0035] Further, the inventors found that when by A: B value greater than 70, or A: B value is less than 1:50, with the use of two-component case no synergistic effect, and the co-toxicity coefficient is calculated by less than 120.

[0036] 田间药效试验: [0036] Field Trial:

[0037] 用上述实施例制得的农药制剂防治黄瓜灰霉病试验。 [0037] Botrytis cinerea Control tests with the above embodiment pesticide formulations prepared.

[0038] 1、试验处理:本试验药剂用量根据各个成分的不同分别设三个处理浓度,对照药剂分别是农药单剂10%嘧菌胺SC和5%烯唑醇ME及空白清水试验。 [0038] 1, processing test: This test pharmaceutical dosage depending on the individual components are arranged three treatment concentration, control drug are single dose of pesticide mepanipyrim SC 10% and 5% diniconazole ME and blank test water.

[0039] 2、试验方法每个小区面积为66. 7m2,重复3次;施药前调查及防治后的调查药效方法为:在试验处理区内随机取样5点,按照国家田间试验相关标准进行病情分级,计算防效。 [0039] 2. Test method of each cell area 66. 7m2, repeated three times; Investigation Investigation Method efficacy before treatment and prevention of post-: 5:00 random sampling test treatment zone, the field test in accordance with national standards for disease classification, control effect is calculated. 试验结果见表2: The results in Table 2:

[0040] 表2田间试验效果[0041 ] [0040] Table 2 Field Tests [0041]

Figure CN105360136AD00071

Figure CN105360136AD00081

[0043] 通过室内生测和田间药效结果表明,嘧菌胺与烯唑醇组合物具有明显的协同增效作用,组合物的防治效果优良,防治效果均好于单剂品种,在农业应用中具有应用价值。 [0043] by bioassay and field results show that efficacy, mepanipyrim and diniconazole composition has obvious synergistic effect, an excellent prevention effect of the composition, control effect was better than single agent species in agricultural applications It has a value.

[0044] 两种活性化合物可以加工成允许的任意一种剂型,下面以具体的实施例说明两种有效成分加工成的制剂,但是该两种活性成分可以加工的制剂不仅限于以下所列。 [0044] The two active compounds can be processed into one dosage form of any allowed, following specific examples illustrate the two active ingredients into the formulation, but the two active ingredients can be processed is not limited to the formulation listed below.

[0045] 实施例1 :15%嘧菌胺•烯唑醇可湿性粉剂(1 :2) [0045] Example 1: 15% • mepanipyrim diniconazole WP (1: 2)

[0046] 将嘧菌胺5g、烯唑醇10g、净洗剂LS(对甲氧基脂肪酰胺基苯磺酸钠)2g、扩散剂ΝΝ0 (亚甲基双萘磺酸钠)4g、白炭黑5g,高岭土加至100g混合物进行气流粉碎,制得有效成分质量百分比为15%嘧菌胺•烯唑醇可湿性粉剂。 [0046] The mepanipyrim 5g, diniconazole 10g, the LS detergent (methoxy-benzene sulfonate of fatty acid amide) 2g, diffusing agent ΝΝ0 (methylene-bis-naphthalene sulfonate) 4g, white carbon black 5g, 100g of kaolin was added to the mixture to jet milling, to obtain the mass percentage of 15% active ingredient mepanipyrim • diniconazole wettable powder.

[0047] 实施例2 :15%嘧菌胺•烯唑醇可湿性粉剂(1 :4) [0047] Example 2: 15% • mepanipyrim diniconazole WP (1: 4)

[0048] 将嘧菌胺3g、烯唑醇12g、十二烷基硫酸钠3g、扩散剂NNO4g、白炭黑5g,高岭土加至l〇〇g混合物进行气流粉碎,制得有效成分质量百分比为15%嘧菌胺•烯唑醇可湿性粉剂。 [0048] The mepanipyrim 3g, diniconazole 12g, sodium lauryl sulfate 3g, diffusing agent NNO4g, silica 5g, kaolin was added to the mixture to l〇〇g jet milling, to obtain the percentage by mass of active ingredient • 15% mepanipyrim diniconazole wettable powder.

[0049] 实施例3 :14%嘧菌胺•烯唑醇可湿性粉剂(1 :6) [0049] Example 3: 14% • mepanipyrim diniconazole WP (1: 6)

[0050] 将嘧菌胺2g、烯唑醇12g、十二烷基硫酸钠3g、扩散剂NNO4g、白炭黑5g,高岭土加至l〇〇g混合物进行气流粉碎,制得有效成分质量百分比为14%嘧菌胺•烯唑醇可湿性粉剂。 [0050] The mepanipyrim 2g, diniconazole 12g, sodium lauryl sulfate 3g, diffusing agent NNO4g, silica 5g, kaolin was added to the mixture to l〇〇g jet milling, to obtain the percentage by mass of active ingredient • 14% mepanipyrim diniconazole wettable powder.

[0051] 实施例4 :20%嘧菌胺•烯唑醇悬浮剂(1 :1) [0051] Example 4: 20% • mepanipyrim diniconazole suspension (1: 1)

[0052] 称取10g啼菌胺、10g稀唑醇,木质素2g,聚氧乙稀聚氧丙稀醚4g,黄原胶0. 15g, 乙二醇5g,聚硅氧乙烷0. 10g,硅酸镁铝0.5g,用水补足至100g,在砂磨机的作用下制成有效成分质量百分比为20%嘧菌胺•烯唑醇悬浮剂。 [0052] Weigh 10g bacteria cry amine, 10g dilute hexaconazole, lignin 2g, polyoxyethylene polyoxypropylene ether Ethylene 4g, xanthan gum 0. 15g, ethylene glycol 5g, 10g of 0. The silicone oxide , magnesium aluminum silicate 0.5g, made up with water to 100g, by mass percent active ingredient are made under the action of a sand mill is 20% or mepanipyrim • diniconazole suspending agents.

[0053] 实施例5 :55%嘧菌胺•烯唑醇水乳剂(1 :10) [0053] Example 5: 55% • mepanipyrim diniconazole aqueous emulsion (1: 10)

[0054] 称取5g嘧菌胺、50g烯唑醇、苯乙基酚聚氧乙烯醚磷酸酯3g、农乳33#2g、烷基酚聚氧乙烯醚lg,溶剂油13g,加水至100g。 [0054] Weigh 5g mepanipyrim, 50g diniconazole, phenethyl phenol polyoxyethylene ether phosphate 3g, Agricultural Emulsifier 33 # 2g, polyoxyethylene alkylphenol ether lg, 13g oil solvent, water was added to 100g. 将以上原料按常规配制水乳剂的方法投入混合釜中高速混合,制成有效成分质量百分比为55%嘧菌胺•烯唑醇水乳剂。 The above ingredients formulated in aqueous emulsion by conventional methods into a mixing tank of high speed mixing to prepare a mass percentage of 55% active ingredient mepanipyrim • diniconazole aqueous emulsion.

[0055] 实施例6 :42%嘧菌胺•烯唑醇乳油(1 :20) [0055] Example 6: 42% • mepanipyrim diniconazole EC (1: 20)

[0056] 称取2g嘧菌胺、40g烯唑醇,十二烷基苯磺酸钙8g、苯乙基酚聚氧乙烯醚5g、溶剂油至l〇〇g。 [0056] Weigh 2g mepanipyrim, 4Og diniconazole, calcium dodecylbenzenesulfonate 8g, phenethyl phenol polyoxyethylene ether 5g, solvent to oil l〇〇g. 将以上原料按常规配制乳油的方法投入混合釜中混合,制成有效成分质量百分比为42 %嘧菌胺•烯唑醇乳油。 The method of these raw materials by a conventional mixing kettle into an emulsifiable concentrate formulation was mixed to prepare a mass percentage of 42% active ingredient mepanipyrim • diniconazole EC.

[0057] 实施例7 :70%嘧菌胺•烯唑醇乳油(2. 5 :1) [0057] Example 7: 70% mepanipyrim EC • diniconazole (2.5: 1)

[0058] 称取50g嘧菌胺、20g烯唑醇,十二烷基苯磺酸钙5g、苯乙基酚聚氧乙烯醚2g、蓖麻油聚氧乙烯醚2g、溶剂油至100g。 [0058] mepanipyrim weighed 50g, 20g diniconazole, calcium dodecylbenzenesulfonate 5g, phenethyl phenol polyoxyethylene ether 2g, polyoxyethylene castor oil 2g, mineral spirits to 100g. 将以上原料按常规配制乳油的方法投入混合釜中混合, 制成有效成分质量百分比为70%嘧菌胺•烯唑醇乳油。 The above ingredients formulated into an emulsifiable concentrate of a conventional mixing kettle were mixed to prepare a mass percentage of 70% active ingredient mepanipyrim • diniconazole EC.

[0059] 实施例8 :18 %嘧菌胺•烯唑醇水分散颗粒剂(5 :1) [0059] Example 8: 18% • mepanipyrim diniconazole water-dispersible granules (5: 1)

[0060] 称取15g啼菌胺、3g稀唑醇,木质磺酸钠8g、十二烷基硫酸钠2g、硫酸铵5g,聚乙烯醇5g,硼砂2g,硅藻土28g补足至100g,将以上原料按水分散颗粒剂方法制成有效成分质量百分比为18 %嘧菌胺•烯唑醇水分散颗粒剂。 [0060] Weigh 15g bacteria cry amine, 3g dilute hexaconazole, sodium lignosulfonate 8g, sodium lauryl sulfate 2g, ammonium sulfate 5g, polyvinyl 5g, borax 2g, diatomaceous earth made up to 28g 100g, the the above ingredients according to the quality of water-dispersible granules method percentage of 18% active ingredient prepared mepanipyrim • diniconazole water-dispersible granules.

[0061] 实施例9 :11%嘧菌胺•烯唑醇乳油(10 :1) [0061] Example 9: 11% • mepanipyrim diniconazole EC (10: 1)

[0062] 称取10g嘧菌胺、lg烯唑醇,十二烷基苯磺酸钙6g、苯乙基酚聚氧乙烯醚7g、溶剂油至l〇〇g。 [0062] Weigh 10g mepanipyrim, lg diniconazole, calcium dodecylbenzenesulfonate 6g, phenethyl phenol polyoxyethylene ether 7g, l〇〇g solvent to oil. 将以上原料按常规配制乳油的方法投入混合釜中混合,制成有效成分质量百分比为11 %嘧菌胺•烯唑醇乳油。 The above ingredients formulated into an emulsifiable concentrate of a conventional mixing kettle were mixed to prepare a mass percentage of 11% active ingredient mepanipyrim • diniconazole EC.

[0063] 实施例10 :31. 5%嘧菌胺•烯唑醇微乳剂(20 :1) [0063] Example 10: 31 • 5% mepanipyrim diniconazole microemulsion (20: 1)

[0064] 称取30g嘧菌胺、1. 5g烯唑醇、十二烷基苯磺酸钙6g、苯乙基酚聚氧乙烯醚磷酸酯3g、农乳33#2g、烷基酚聚氧乙烯醚lg,异丙醇10g,加水至100g。 [0064] Weigh 30g mepanipyrim, 1. 5g diniconazole, calcium dodecylbenzenesulfonate 6g, phenethyl phenol polyoxyethylene ether phosphate 3g, Agricultural Emulsifier 33 # 2g, alkylphenol vinyl ethers lg, isopropanol 10g, add water to 100g. 将以上原料按常规配制微乳剂的方法投入混合釜中混合,制成有效成分质量百分比为31. 5%嘧菌胺•烯唑醇微乳剂。 The above ingredients are mixed into a conventional mixing kettle formulated microemulsions, mass% active ingredient is made 31.5% mepanipyrim • diniconazole microemulsion.

[0065] 实施例11 :31%嘧菌胺•烯唑醇乳油(30 :1) [0065] Example 11: 31% • mepanipyrim diniconazole EC (30: 1)

[0066] 称取30g嘧菌胺、lg烯唑醇,十二烷基苯磺酸钙4g、苯乙基酚聚氧乙烯醚4g、溶剂油至l〇〇g。 [0066] Weigh 30g mepanipyrim, lg diniconazole, calcium dodecylbenzenesulfonate 4g, phenethyl phenol polyoxyethylene ether 4g, solvent to oil l〇〇g. 将以上原料按常规配制乳油的方法投入混合釜中混合,制成有效成分质量百分比为31 %嘧菌胺•烯唑醇乳油。 The method of these raw materials by a conventional mixing kettle into an emulsifiable concentrate formulation was mixed to prepare a mass percentage of 31% active ingredient mepanipyrim • diniconazole EC.

[0067] 实施例12 :51%嘧菌胺•烯唑醇悬浮剂(50 :1) [0067] Example 12: 51% • mepanipyrim diniconazole suspension (50: 1)

[0068] 称取50g啼菌胺、lg稀唑醇,木质素2g,聚氧乙稀聚氧丙稀醚4g,黄原胶0· 15g,乙二醇5g,聚硅氧乙烷0. 10g,硅酸镁铝0. 5g,用水补足至100g,在砂磨机的作用下制成有效成分质量百分比为51 %嘧菌胺•烯唑醇悬浮剂。 [0068] Weigh 50g bacteria cry amine, lg diluted hexaconazole, lignin 2g, polyoxyethylene polyoxypropylene ether Ethylene 4g, xanthan gum 0 · 15g, ethylene glycol 5g, 0. 10g silicone oxide , magnesium aluminum silicate 0. 5g, made up with water to 100g, by mass percent active ingredient is made 51% mepanipyrim • diniconazole suspension under the action of a sand mill.

[0069] 实施例13 :32%嘧菌胺•烯唑醇微乳剂(1 :15) [0069] Example 13: 32% • mepanipyrim diniconazole microemulsion (1:15)

[0070] 称取2g嘧菌胺、30g烯唑醇、十二烷基苯磺酸钙6g、苯乙基酚聚氧乙烯醚磷酸酯3g、农乳33#2g、烷基酚聚氧乙烯醚lg,异丙醇10g,加水至100g。 [0070] Weigh 2g mepanipyrim, diniconazole 30g, calcium dodecylbenzenesulfonate 6g, phenethyl phenol polyoxyethylene ether phosphate 3g, Agricultural Emulsifier 33 # 2g, alkylphenol ether lg, isopropanol 10g, add water to 100g. 将以上原料按常规配制微乳剂的方法投入混合釜中混合,制成有效成分质量百分比为32%嘧菌胺•烯唑醇微乳剂。 The above ingredients are mixed into a conventional mixing kettle microemulsions formulated, the mass percentage of 32% active ingredient prepared mepanipyrim • diniconazole microemulsion.

[0071] 实施例14 :6%嘧菌胺•烯唑醇水乳剂(1 :5) [0071] Example 14: 6% • mepanipyrim diniconazole aqueous emulsion (1: 5)

[0072] 称取lg嘧菌胺、5g烯唑醇、苯乙基酚聚氧乙烯醚磷酸酯3g、农乳33#2g、烷基酚聚氧乙烯醚lg,溶剂油13g,加水至100g。 [0072] Weigh lg mepanipyrim, 5g diniconazole, phenethyl phenol polyoxyethylene ether phosphate 3g, Agricultural Emulsifier 33 # 2g, polyoxyethylene alkylphenol ether lg, 13g oil solvent, water was added to 100g. 将以上原料按常规配制水乳剂的方法投入混合釜中高速混合,制成有效成分质量百分比为6%嘧菌胺•烯唑醇水乳剂。 The above ingredients formulated in aqueous emulsion by conventional methods into a mixing tank of high speed mixing to prepare a mass percent active ingredient of 6% • mepanipyrim diniconazole aqueous emulsion.

[0073] 实施例15 :62%嘧菌胺•烯唑醇微乳剂(1 :30) [0073] Example 15: 62% • mepanipyrim diniconazole microemulsion (1:30)

[0074] 称取2g嘧菌胺、60g烯唑醇、十二烷基苯磺酸钙6g、苯乙基酚聚氧乙烯醚磷酸酯3g、农乳33#2g、烷基酚聚氧乙烯醚lg,异丙醇10g,加水至100g。 [0074] Weigh 2g mepanipyrim, diniconazole 60g, calcium dodecylbenzenesulfonate 6g, phenethyl phenol polyoxyethylene ether phosphate 3g, Agricultural Emulsifier 33 # 2g, alkylphenol ether lg, isopropanol 10g, add water to 100g. 将以上原料按常规配制微乳剂的方法投入混合釜中混合,制成有效成分质量百分比为62%嘧菌胺•烯唑醇微乳剂。 The above ingredients are mixed into a conventional mixing kettle microemulsions formulated, the mass percentage of 62% active ingredient prepared mepanipyrim • diniconazole microemulsion.

[0075] 实施例16 :51 %嘧菌胺•烯唑醇悬浮剂(1 :50) [0075] Example 16: 51% • mepanipyrim diniconazole suspension (1: 50)

[0076] 称取lg啼菌胺、50g稀唑醇,木质素2g,聚氧乙稀聚氧丙稀醚4g,黄原胶0. 15g,乙二醇5g,聚硅氧乙烷0. 10g,硅酸镁铝0. 5g,用水补足至100g,在砂磨机的作用下制成有效成分质量百分比为51 %嘧菌胺•烯唑醇悬浮剂。 [0076] Weigh lg cry bacteria amine, 50g dilute hexaconazole, lignin 2g, polyoxyethylene polyoxypropylene ether Ethylene 4g, xanthan gum 0. 15g, ethylene glycol 5g, 0. 10g silicone oxide , magnesium aluminum silicate 0. 5g, made up with water to 100g, by mass percent active ingredient is made 51% mepanipyrim • diniconazole suspension under the action of a sand mill.

[0077] 实施例17 :7%嘧菌胺•烯唑醇水分散颗粒剂(1 :2· 5) [0077] Example 17: 7% • mepanipyrim diniconazole water-dispersible granules (1: 2.5)

[0078] 称取2g啼菌胺、5g稀唑醇,木质素磺酸钠8g、十二烷基硫酸钠2g、硫酸铵5g,聚乙烯醇5g,硼砂2g,白炭黑3g、硅藻土补足至100g,将以上原料按水分散颗粒剂方法制成有效成分质量百分比为7%嘧菌胺•烯唑醇水分散颗粒剂。 [0078] Weigh 2g amine cry bacteria, 5g dilute hexaconazole, sodium lignosulfonate 8g, 2g sodium dodecyl sulfate, ammonium sulfate 5g, polyvinyl 5g, 2g borax, silica 3g, diatomaceous earth made up to 100g, these raw materials by the method of water-dispersible granules prepared by mass percent active ingredient 7% mepanipyrim • diniconazole water-dispersible granules.

Claims (10)

1. 一种含嘧菌胺和烯唑醇的杀菌组合物,其特征在于该杀菌组合物以嘧菌胺和烯唑醇为主要有效成分,其中嘧菌胺与烯唑醇的质量比为1~70 :1~50。 1. A fungicidal composition containing mepanipyrim and diniconazole, characterized in that the germicidal composition to mepanipyrim and diniconazole as the main active ingredient, wherein the mass ratio of mepanipyrim and diniconazole is 1 ~ 70: 1 ~ 50.
2. 根据权利要求1所述的杀菌组合物,其特征在于所述嘧菌胺与烯唑醇的质量比为1 ~50 :1 ~50。 2. The germicidal composition according to claim 1, characterized in that the mass ratio of amine to azoxystrobin diniconazole 1 to 50: 1 ~ 50.
3. 根据权利要求2所述的杀菌组合物,其特征在于所述嘧菌胺与烯唑醇的质量比为1 ~10 :1 ~10。 3. The germicidal composition according to claim 2, wherein said amine with azoxystrobin diniconazole mass ratio of 1 ~ 10: 1 ~ 10.
4. 根据权利要求3所述的杀菌组合物,其特征在于所述嘧菌胺与烯唑醇的质量比为1~5 :1~4〇 4. The germicidal composition according to claim 3, characterized in that the mass ratio of mepanipyrim and diniconazole 1 to 5: 1 4〇
5. 根据权利要求1所述的杀菌组合物,其特征在于所述的嘧菌胺和烯唑醇二者占组合物的质量百分含量为2-80%。 5. The germicidal composition according to claim 1, wherein both of said mepanipyrim and diniconazole account the mass percentage of 2-80% of the composition.
6. 根据权利要求5所述的杀菌组合物,其特征在于所述的嘧菌胺和烯唑醇二者占组合物的质量百分含量为10-40%。 6. A fungicidal composition as claimed in claim 5, wherein both of said mepanipyrim and diniconazole account the mass percentage of 10 to 40% of the composition.
7. 根据权利要求1所述的杀菌组合物,其特征在于以嘧菌胺和烯唑醇为主要有效成分和农药助剂、赋型剂配制成农药上允许的任意一种剂型。 7. The germicidal composition according to claim 1, characterized in mepanipyrim and diniconazole as a main active ingredient of pesticides and adjuvants, excipients formulated into any dosage forms permit the pesticide.
8. 根据权利要求7所述的杀菌组合物,其特征在于所述的剂型是乳油、悬浮剂、水乳剂、可湿性粉剂、微乳剂或水分散颗粒剂。 8. The germicidal composition according to claim 7, wherein said dosage forms are emulsifiable concentrates, suspensions, water emulsions, wettable powders, microemulsions or water-dispersible granules.
9. 权利要求1所述的杀菌组合物在制备防治植物真菌病害药物上的应用。 Germicidal composition of claim 1 applied to the preparation of a medicament for controlling plant fungal disease of claim 9.
10. 根据权利要求9所述的应用,其特征在于所述的植物真菌病害为白粉病、灰霉病、 褐腐病、黑粉病、锈病中的至少一种。 10. The use according to claim 9, wherein said plant fungal disease of powdery mildew, gray mold, brown rot, smut, at least one of rust.
CN201510751885.3A 2015-11-06 2015-11-06 Sterilization composition containing mepanipyrim and diniconazole and application thereof CN105360136A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4814338A (en) * 1985-10-30 1989-03-21 Kumiai Chemical Industry Co., Ltd. Pyrimidine derivative, process for preparing same and agricultural or horticultural fungicidal composition containing same
CN1385069A (en) * 2001-05-15 2002-12-18 马韵升 Pyrimethanil disinfection composition
CN104012541A (en) * 2013-02-28 2014-09-03 陕西美邦农药有限公司 Fungicidal composition containing diflumetorim and triazole

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4814338A (en) * 1985-10-30 1989-03-21 Kumiai Chemical Industry Co., Ltd. Pyrimidine derivative, process for preparing same and agricultural or horticultural fungicidal composition containing same
CN1385069A (en) * 2001-05-15 2002-12-18 马韵升 Pyrimethanil disinfection composition
CN104012541A (en) * 2013-02-28 2014-09-03 陕西美邦农药有限公司 Fungicidal composition containing diflumetorim and triazole

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