CN105329543A - Integrated packaging and pre-filling-sealing pen-type injector - Google Patents
Integrated packaging and pre-filling-sealing pen-type injector Download PDFInfo
- Publication number
- CN105329543A CN105329543A CN201410398370.5A CN201410398370A CN105329543A CN 105329543 A CN105329543 A CN 105329543A CN 201410398370 A CN201410398370 A CN 201410398370A CN 105329543 A CN105329543 A CN 105329543A
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- bottle
- box body
- cartridge
- filling
- holes
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- 238000007789 sealing Methods 0.000 title claims abstract description 5
- 238000004806 packaging method and process Methods 0.000 title abstract description 9
- 238000011049 filling Methods 0.000 claims abstract description 16
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims abstract description 7
- 229910052782 aluminium Inorganic materials 0.000 claims abstract description 7
- 239000000203 mixture Substances 0.000 claims description 3
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims 1
- 239000004411 aluminium Substances 0.000 claims 1
- 239000005297 pyrex Substances 0.000 claims 1
- 238000004140 cleaning Methods 0.000 abstract description 8
- 238000001035 drying Methods 0.000 abstract description 5
- 230000001954 sterilising effect Effects 0.000 abstract description 5
- 239000005388 borosilicate glass Substances 0.000 abstract description 4
- 239000012141 concentrate Substances 0.000 abstract description 3
- 238000012858 packaging process Methods 0.000 abstract description 3
- 239000003814 drug Substances 0.000 description 8
- 229940079593 drug Drugs 0.000 description 7
- 238000000034 method Methods 0.000 description 4
- 238000004659 sterilization and disinfection Methods 0.000 description 4
- 238000012371 Aseptic Filling Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000010276 construction Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 229940126534 drug product Drugs 0.000 description 1
- 238000005429 filling process Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000005022 packaging material Substances 0.000 description 1
- 238000009512 pharmaceutical packaging Methods 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/008—Racks for supporting syringes or needles
Landscapes
- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Packages (AREA)
Abstract
本发明涉及一种集成式包装预灌封卡式瓶,其由托盘盒体、蜂巢式中间体、卡式瓶、里层瓶盖纸、外层盒盖纸组成,所述蜂巢式中间体上设有若干孔洞,所述卡式瓶的硼硅玻璃套筒前端通过垫片和铝盖密封,后端敞口,所述卡式瓶密封的前端朝下,后端敞口朝上,分别对应装配在蜂巢式中间体的每个孔洞中,装满卡式瓶的蜂巢式中间体放置在托盘盒体中,所述里层瓶盖纸覆盖在托盘盒体中卡式瓶上,外层盒盖纸覆盖在托盘盒体上,边缘与托盘盒体上沿粘合固定。本发明构造合理,其将卡式瓶的清洗、烘干、灭菌作业集中在蜂巢式中间体式包装过程中,其使用方便,药品制造商可直接进行灌装作业。
The invention relates to an integrated packaging pre-filling and sealing card bottle, which is composed of a tray box body, a honeycomb intermediate, a card bottle, an inner layer of bottle cap paper, and an outer layer of box cover paper. There are several holes, the front end of the borosilicate glass sleeve of the cartridge is sealed by a gasket and an aluminum cover, and the rear end is open. Assembled in each hole of the honeycomb intermediate, the honeycomb intermediate filled with cartridges is placed in the tray box, the inner bottle cap paper covers the cartridges in the tray box, and the outer box The cover paper is covered on the tray box body, and the edge is bonded and fixed to the upper edge of the tray box body. The invention has a reasonable structure, concentrates the cleaning, drying and sterilizing operations of the cartridge bottles in the honeycomb intermediate packaging process, is convenient to use, and the pharmaceutical manufacturer can directly perform the filling operation.
Description
技术领域 technical field
本发明涉及医用药品包装材料,具体地说是一种集成式包装预灌封卡式瓶。 The invention relates to a medical drug packaging material, in particular to an integrated packaging pre-filling and sealing cartridge bottle.
背景技术 Background technique
我们知道,卡式瓶类似没有推杆的注射器,该瓶瓶口用橡胶垫片和铝盖密封,尾部用橡胶活塞密封。卡式瓶前部安装注射针,使用时置入重复使用的卡式注射架或称注射笔中,使用过程药液不与注射器任何部件接触。目前,国内外市场上普遍使用的卡式瓶为散装的卡式瓶,制药企业在使用卡式瓶时,需要经过清洗、隧道烘箱之后才能进行灌装药物。这对于制药企业来说,灌装之前的设备、工艺投资巨大,对于中小型药厂来说非常困难。 We know that the cartridge bottle is similar to a syringe without a push rod. The mouth of the bottle is sealed with a rubber gasket and an aluminum cap, and the tail is sealed with a rubber piston. An injection needle is installed at the front of the cartridge, and it is put into a reusable cartridge injection holder or injection pen when in use, and the liquid medicine does not come into contact with any part of the syringe during use. At present, the cartridges commonly used in domestic and foreign markets are bulk cartridges. When pharmaceutical companies use cartridges, they need to go through cleaning and tunnel oven before filling drugs. For pharmaceutical companies, the investment in equipment and processes before filling is huge, which is very difficult for small and medium-sized pharmaceutical companies.
发明内容 Contents of the invention
本发明所要解决的技术问题是克服上述现有技术的不足,提供一种构造合理,使用方便,可直接进行灌装作业的集成式包装预灌封卡式瓶。 The technical problem to be solved by the present invention is to overcome the deficiencies of the above-mentioned prior art, and provide an integrated packaging pre-filled cartridge bottle with reasonable structure, convenient use, and direct filling operation.
本发明解决上述技术问题采用的技术方案是:一种集成式包装预灌封卡式瓶,其由托盘盒体、蜂巢式中间体、卡式瓶、里层瓶盖纸、外层盒盖纸组成,所述蜂巢式中间体上设有若干孔洞,其特征是:所述卡式瓶的硼硅玻璃套筒前端通过垫片和铝盖密封,后端敞口,所述卡式瓶密封的前端朝下,后端敞口朝上,分别对应装配在蜂巢式中间体的每个孔洞中,装满卡式瓶的蜂巢式中间体放置在托盘盒体中,所述里层瓶盖纸覆盖在托盘盒体中卡式瓶上,外层盒盖纸覆盖在托盘盒体上,边缘与托盘盒体上沿粘合固定。 The technical solution adopted by the present invention to solve the above technical problems is: an integrated packaging pre-filled and sealed cartridge bottle, which consists of a tray box body, a honeycomb intermediate, a cartridge bottle, an inner layer of bottle cap paper, and an outer layer of box cover paper Composition, the honeycomb intermediate body is provided with a number of holes, characterized in that: the front end of the borosilicate glass sleeve of the cartridge is sealed by a gasket and an aluminum cover, the rear end is open, and the sealed cartridge The front end is facing down, and the rear end is open and facing upwards, which are respectively assembled in each hole of the honeycomb intermediate body. The honeycomb intermediate body filled with cartridge bottles is placed in the tray box, and the inner layer of bottle cap paper is covered. On the cassette bottle in the tray box, the outer cover paper is covered on the tray box, and the edge is glued and fixed to the upper edge of the tray box.
本发明所述蜂巢式中间体上的孔洞的数量、位置、间距有规律排列;所述卡式瓶经过清洗、烘干、灭菌,集成装配在蜂巢式中间体和托盘盒体中,成为集成的蜂巢式包装预灌封卡式瓶,对照现有技术,本发明构造合理,其将卡式瓶的清洗、烘干、灭菌作业集中在集成式包装过程中,而灌装过程则不再需要清洗、烘干、灭菌等作业。成为独立的适于自动化灌装的标准件。适用于药品制造商在制造预灌封卡式瓶装药物的时候直接自动化无菌灌装。而且灭菌后的集成式包装预灌封卡式瓶能够长时间保存,制药企业可以随时灌装。其使用方便,药品制造商可直接进行无菌灌装作业,大大简化了药品制造商在制造预灌封卡式瓶药物时,卡式瓶要经过清洗、隧道烘箱之后才能进行灌装药物的工艺过程,也降低了设备投资。 The number, position, and spacing of the holes on the honeycomb intermediate body of the present invention are arranged regularly; the cartridge bottle is cleaned, dried, and sterilized, and integrated into the honeycomb intermediate body and the tray box to form an integrated Compared with the prior art, the present invention has a reasonable structure, and it concentrates the cleaning, drying and sterilization operations of the cartridges in the integrated packaging process, while the filling process is no longer Need cleaning, drying, sterilization and other operations. Become an independent standard part suitable for automatic filling. It is suitable for pharmaceutical manufacturers to directly automate aseptic filling when manufacturing pre-filled cartridge bottles. Moreover, the sterilized integrated packaging pre-filled cartridges can be stored for a long time, and pharmaceutical companies can fill them at any time. It is easy to use, and the drug manufacturer can directly carry out the aseptic filling operation, which greatly simplifies the process of the drug manufacturer when manufacturing the pre-filled cartridge drug, the cartridge bottle must be cleaned and the tunnel oven can be used to fill the drug The process also reduces equipment investment.
附图说明 Description of drawings
下面结合附图对本发明作进一步的描述。 The present invention will be further described below in conjunction with the accompanying drawings.
图1是本发明组成结构分解示意图。 Fig. 1 is an exploded schematic diagram of the composition structure of the present invention.
图2是本发明卡式瓶示意图。 Figure 2 is a schematic diagram of the cartridge of the present invention.
图3是本发明蜂巢式中间体示意图。 Fig. 3 is a schematic diagram of the honeycomb intermediate of the present invention.
图中1.外层盒盖纸,2.里层瓶盖纸,3.卡式瓶,4.蜂巢式中间体,5.托盘盒体。31.硼硅玻璃套筒,32.铝盖,33.垫片。 In the figure 1. Outer box cover paper, 2. Inner bottle cover paper, 3. Cassette bottle, 4. Honeycomb intermediate, 5. Tray box body. 31. Borosilicate glass sleeve, 32. Aluminum cover, 33. Gasket.
具体实施方式 detailed description
从图1、图2中可以看出,一种集成式包装预灌封卡式瓶,其由托盘盒体5、蜂巢式中间体4、卡式瓶3、里层瓶盖纸2、外层盒盖纸1组成,所述蜂巢式中间体4上设有若干孔洞,所述卡式瓶3的硼硅玻璃套筒31前端通过垫片33和铝盖32密封,后端敞口,所述卡式瓶3前部密封端朝下,后端敞口朝上,分别对应装配在蜂巢式中间体4的每个孔洞中,装满卡式瓶的蜂巢式中间体4放置在托盘盒体5中,所述里层瓶盖纸2覆盖在托盘盒体中卡式瓶后端敞口上,外层盒盖纸1覆盖在托盘盒体5上,边缘与托盘盒体5上沿粘合固定。 As can be seen from Figures 1 and 2, an integrated packaging pre-filled cartridge bottle consists of a tray box body 5, a honeycomb intermediate body 4, a cartridge bottle 3, an inner layer cap paper 2, an outer layer The box cover paper 1 is composed of the honeycomb intermediate body 4 with several holes, the front end of the borosilicate glass sleeve 31 of the cartridge bottle 3 is sealed by a gasket 33 and an aluminum cover 32, and the rear end is open. The sealed end of the front part of the cartridge 3 faces downwards, and the rear end opens upwards, which are respectively assembled in each hole of the honeycomb intermediate 4, and the honeycomb intermediate 4 filled with the cartridge is placed on the tray box 5 Among them, the inner bottle cap paper 2 is covered on the rear end opening of the cartridge in the tray box body, the outer layer cover paper 1 is covered on the tray box body 5, and the edge is bonded and fixed to the upper edge of the tray box body 5 .
本发明所述卡式瓶3是经过清洗、烘干、灭菌的卡式瓶。集成装配在蜂巢式中间体和托盘盒体中,成为独立的产品。 The cartridge bottle 3 of the present invention is a cartridge bottle that has been cleaned, dried and sterilized. It is integrated and assembled in the honeycomb intermediate body and pallet box, and becomes an independent product.
本发明所述蜂巢式中间体上的孔洞的数量、位置、间距有规律排列,孔洞的内外径、孔间距等均为设计的标准值,成为能够适应自动化清洗、包装、灌装的标准件。例如,所述蜂巢式中间体4上纵向设有10列孔洞,横向设有10列孔洞,每列均设有10个孔洞,孔洞的内外径、孔间距相等。如图3所示。所述孔洞的内径、深度与卡式瓶外径和高度相对应,以适于卡式瓶的装配。这样可轻易实现清洗、包装、灌装的自动化。适用于药品制造商在制造预灌封卡式瓶装药物的时候直接自动化灌装。卡式瓶所用的胶塞、铝盖分别为独立包装的产品。均为经过清洁、灭菌的产品,分别独立包装。制药企业在使用的时候,可直接进行无菌灌装即可。 The number, position, and spacing of the holes on the honeycomb intermediate body of the present invention are regularly arranged, and the inner and outer diameters of the holes, the hole spacing, etc. are designed standard values, and become standard parts that can adapt to automatic cleaning, packaging, and filling. For example, the honeycomb intermediate body 4 is provided with 10 rows of holes in the vertical direction and 10 rows of holes in the horizontal direction, each row is provided with 10 holes, and the inner and outer diameters of the holes and the hole spacing are equal. As shown in Figure 3. The inner diameter and depth of the hole correspond to the outer diameter and height of the cartridge, so as to be suitable for the assembly of the cartridge. In this way, the automation of cleaning, packaging and filling can be easily realized. It is suitable for pharmaceutical manufacturers to directly automate filling when manufacturing pre-filled cartridges. The rubber stoppers and aluminum caps used in the cartridges are individually packaged products. All are cleaned and sterilized products, and are individually packaged. When pharmaceutical companies use it, they can directly carry out aseptic filling.
本发明清洗、烘干后的卡式瓶摆放在蜂巢式中间体的孔洞内,各卡式瓶瓶体之间被相互隔开,有效解决瓶体之间相互碰撞摩擦导致的破碎、划痕等问题;同时也防止瓶体之间摆放过于密集导致的贴近部位灭菌不彻底的问题。 The cartridge bottles after cleaning and drying in the present invention are placed in the holes of the honeycomb intermediate body, and the cartridge bodies are separated from each other, which effectively solves the broken and scratches caused by the mutual collision and friction between the bottle bodies and other problems; at the same time, it also prevents the problem of incomplete sterilization of close parts caused by placing too densely between the bottles.
本发明托盘盒体为硬质塑料材料,卡式瓶放置在蜂巢式中间体和托盘盒体内,定位准确,有效解决了卡式瓶在运输过程中由于震荡、搬运、跌落等因素造成的玻璃破损。 The tray box body of the present invention is made of hard plastic material, and the cartridge bottle is placed in the honeycomb intermediate body and the tray box body, and the positioning is accurate, which effectively solves the glass damage caused by factors such as vibration, handling, and falling of the cartridge bottle during transportation. .
本发明构造合理,其将卡式瓶的清洗、烘干、灭菌作业集中在蜂巢式中间体式包装过程中,成为独立的适于自动化灌装的标准件。该产品大大减小了制药企业的投资与厂房建设。制药企业在生产一种新型的产品时,只需要进行灌装设备的投资即可,降低投资与投资周期,大大缩短药物的上市周期。提高制药企业的灌装效率。传统的卡式瓶在制药企业为逐个定位灌装药物。预灌封卡式瓶被摆放在蜂巢式中间体内,蜂巢式中间体的大小、蜂巢式中间体孔的内外径、孔间距等均为设计的标准值,这样可轻易实现双头、五头甚至十头的自动化灌装,大大提高的药物灌装的效率。 The invention has a reasonable structure, concentrates the cleaning, drying and sterilization operations of the cartridge bottle in the honeycomb intermediate packaging process, and becomes an independent standard part suitable for automatic filling. This product greatly reduces the investment and plant construction of pharmaceutical companies. When a pharmaceutical company produces a new type of product, it only needs to invest in filling equipment, which reduces investment and investment cycle, and greatly shortens the drug listing cycle. Improve the filling efficiency of pharmaceutical enterprises. Traditional cartridges are used in pharmaceutical companies to fill drug products position by position. The pre-filled cartridge bottle is placed in the honeycomb intermediate body. The size of the honeycomb intermediate body, the inner and outer diameters of the honeycomb intermediate body holes, and the hole spacing are all standard values in the design, so that double-headed and five-headed bottles can be easily realized. Even the automatic filling of ten heads greatly improves the efficiency of drug filling.
Claims (2)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410398370.5A CN105329543A (en) | 2014-08-14 | 2014-08-14 | Integrated packaging and pre-filling-sealing pen-type injector |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410398370.5A CN105329543A (en) | 2014-08-14 | 2014-08-14 | Integrated packaging and pre-filling-sealing pen-type injector |
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| Publication Number | Publication Date |
|---|---|
| CN105329543A true CN105329543A (en) | 2016-02-17 |
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|---|---|---|---|
| CN201410398370.5A Pending CN105329543A (en) | 2014-08-14 | 2014-08-14 | Integrated packaging and pre-filling-sealing pen-type injector |
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| CN (1) | CN105329543A (en) |
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| CN1313167A (en) * | 2000-02-22 | 2001-09-19 | 株式会社爱克雷库 | Processing method and mist supplier therefor |
| CN1474706A (en) * | 2000-11-20 | 2004-02-11 | ���˶ٵϿ�ɭ��˾ | Containers for articles intended to be sterilized with high temperature sterilizing fluids |
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Application publication date: 20160217 |