CN105327110A - Medicine for treating allergic rhinitis - Google Patents

Medicine for treating allergic rhinitis Download PDF

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Publication number
CN105327110A
CN105327110A CN201510776536.7A CN201510776536A CN105327110A CN 105327110 A CN105327110 A CN 105327110A CN 201510776536 A CN201510776536 A CN 201510776536A CN 105327110 A CN105327110 A CN 105327110A
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China
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parts
medicine
allergic rhinitis
treatment
rhizoma atractylodis
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CN201510776536.7A
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Chinese (zh)
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潘灵灵
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潘灵灵
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Priority to CN201510776536.7A priority Critical patent/CN105327110A/en
Publication of CN105327110A publication Critical patent/CN105327110A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/26Aristolochiaceae (Birthwort family), e.g. heartleaf
    • A61K36/268Asarum (wild ginger)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284Atractylodes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/62Nymphaeaceae (Water-lily family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/81Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815Lycium (desert-thorn)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8967Lilium, e.g. tiger lily or Easter lily
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8968Ophiopogon (Lilyturf)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/53Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Abstract

The invention relates to medicine for treating allergic rhinitis. The medicine is prepared from, by weight, 10 parts of rhizoma atractylodis macrocephalae, 9 parts of liquorice, 15 parts of barbary wolfberry fruit, 9 parts of lilies, 8 parts of radix ophiopogonis, 3 parts of folium nelumbinis and 8 parts of herba asari. According to the medicine, rhizoma atractylodis macrocephalae and liquorice can strengthen the spleen and benefit Qi, barbary wolfberry fruit can nourish the kidney and moisten the lung, lilies and radix ophiopogonis can moisten the lung and clear away the heart fire, folium nelumbinis can send up the lucid Yang, and herba asari can dispel cold and open the orifices. All the traditional Chinese medicines are combined to jointly achieve the effects of tonifying the lung, strengthening the spleen, opening the orifices through pungent warming to effectively treat the allergic rhinitis. Clinical experiments prove that the medicine can safely and effectively treat the allergic rhinitis.

Description

A kind of medicine being used for the treatment of allergic rhinitis
Technical field
The present invention relates to a kind of Chinese medicine, be specifically related to a kind of medicine being used for the treatment of allergic rhinitis.
Background technology
Allergic rhinitis and allergic rhinitis, after referring to atopic individuals contact allergen, primarily of medium (mainly histamine) release of IgE mediation, and have the nasal mucosa non-infectious inflammatory disease that panimmunity competent cell and cytokine etc. participate in.
Classical symptom mainly paroxysmal sneeze, clear water sample nasal mucus, nasal obstruction and the rhinocnesmus of allergic rhinitis.Part is with hyposmia.
1. sneeze
For several times paroxysmal outbreak every day, at every turn more than 3, how morning rise or night or contact allergy former after show effect at once.
2. thin nasal discharge
A large amount of clear water sample nasal mucus, can not consciously drip from nostril sometimes.
3. have a stuffy nose
Interval or lasting, one-sided or bilateral, light and heavy degree differs.
4. rhinocnesmus
Most patients intranasal is itched, and pollinosis patient can accompany ophthalmic pruritus, itching in the ear and itching throat.
Diagnosis: more than 2 (containing 2) appear in the symptoms such as clinical symptoms sneeze, clear water sample tears, nasal obstruction, nose are overworked, every day Symptoms last or be accumulated at more than 1 hour.Can with the eye symptom such as ophthalmic pruritus, conjunctival congestion.The common nasal mucosa of sign is pale, edema, nasal cavity watery secretion.Skin prick test is positive, and/or Specificity IgE is positive, feasible nasal provocation test if desired.
Drug therapy
Following factor should be considered: curative effect, safety, expense/effect ratio etc.Conventional intranasal and oral administration, curative effect may be variant between different patient.Without long-term sustained therapeutic effect after drug withdrawal, therefore maintaining treatment is needed to persistence allergic rhinitis.There is not quick drug resistance in the extended treatment time.Intranasal administration has many advantages, and high concentration medicine can directly act on nose, avoid or reduces systemic side effects.But for other anaphylactic diseases patient, medicine needs act on different target organ, and intranasal administration is not optimum selection, recommend systemic drug treatment.Pregnant Patients should be cautious use of various medicine.
(1) the oral or nose 2nd generation of antihistaminic or novel H1 antihistaminic, can effectively alleviate the symptoms such as rhinocnesmus, sneeze and watery nasal discharge.Be applicable to mild intermittent and mild consistent allergic rhinitis, in treating by glucocorticosteroidsin in combination with nose-severe allergic rhinitis.
(2) glucocorticoid nose glucocorticoid, can effectively alleviate the symptoms such as nasal obstruction, watery nasal discharge and sneeze.To the reactionless patient with severe symptoms that maybe can not tolerate nasal medicine of other drug treatment, oral glucocorticoid can be adopted to carry out short term therapy.
(3) anti-leukotriene medicine to allergic rhinitis and asthma effective.
(4) chromone class medicine has certain effect to alleviation sniffle, and eye drop is effective to alleviation eye symptom.
(5) intranasal Decongestant has mitigation to the nasal obstruction symptom that nasal congestion causes, and the course for the treatment of should control within 7 days.
(6) Intranasal anticholinergic agents thing effectively can suppress watery nasal discharge.
Medical material involved in the present invention is recorded in all as seen " China's book on Chinese herbal medicine ".
Summary of the invention
The present invention aims to provide a kind of medicine being used for the treatment of allergic rhinitis, by selecting suitable medical material and proportioning thereof, reaches the object of safe and effective healing allergic rhinitis.
In order to achieve the above object, the present invention is by the following technical solutions:
Be used for the treatment of a medicine for allergic rhinitis, it is characterized in that, it is prepared from by the raw medicinal material of following weight proportion: the Rhizoma Atractylodis Macrocephalae 10 parts, 9 parts, Radix Glycyrrhizae, Fructus Lycii 15 parts, Bulbus Lilii 9 parts, Radix Ophiopogonis 8 parts, 3 parts, Folium Nelumbinis, Herba Asari 8 parts.
Below in conjunction with theories of Chinese materia medica, beneficial effect of the present invention is described:
Inventor thinks, primary disease is mainly due to lung qi virtual loss, and instability of surface, wind and cold is availed oneself of the opportunity to get in, and violate and nose key, pathogen conflicting with vital QI, lung qi must not lead to tune, and body fluid stops gathering, and nose key is jammed, and then causes sneeze, snivel.Enriching of lung qi, depend on the defeated cloth of temper, and the root of gas is at kidney, suffers from a deficiency of the kidney, and takes the photograph to receive to have no right, gas does not return unit to cause primary disease.
The present invention uses: the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae invigorating the spleen and benefiting QI; Fructus Lycii nourishing kidney lung moistening; Bulbus Lilii, lung moistening Radix Ophiopogonis clear away heart-fire; Folium Nelumbinis sending up the lucid YANG; Herba Asari cold expelling is sensible.All medicines share, and play tonifying the lung spleen invigorating altogether, effect that Xin Wen is sensible.Effective treatment of allergic rhinitis.
Below in conjunction with clinical laboratory data, beneficial effect of the present invention is described:
1, physical data
Inventor collects 80 routine Allergic Rhinitis between in June ,-2014 in June, 2012 altogether, wherein man 31 example, female 49 example, and perennial onset 34 example, Seasonal Incidence 46 example, the age is 18 ~ 72 years old, the course of disease 1 ~ 18 year.Treatment group and each 40 examples of matched group are divided at random by medical sequencing.Treatment group man 12 example, female 28 example; Perennial onset 18 example, Seasonal Incidence 22 example; 32 ~ 70 years old age, average (52.0 ± 9.4) year; The course of disease 1 ~ 18 year.Matched group man 19 example, female 21 example; Perennial onset 16 example, Seasonal Incidence 24 example; 32 ~ 70 years old age, average (51.1 ± 11.4) year; The course of disease 1 ~ 17 year.The data there was no significant differences such as two groups of sexes, age, courses of disease, have comparability.
Diagnostic criteria
(1) there is rhinocnesmus, sneeze, nasal discharge and nasal obstruction 4 large symptoms at least 3, more than Symptoms last 0.5-1h, weekly more than 4d; Seasonal rhinitis or pollinosis, annual morbidity season is basically identical, and be consistent with pollen pollinating period (within least 2 years, falling ill in same season).Perennial rhinitis was then fallen ill in most date in 1 year; (2) nasal mucosa form inflammatory changes; (3) the former tuerculoderma of degeneration is positive, and at least one is that more than (++) or (++)/or allergen specific lee are positive; (4) nasal smear eosinophilic granulocyte checks the positive paresthesia epilepsy phase.Mainly can make diagnosis according to first 3, wherein medical history and specificity inspection be Main Diagnosis according to.
2, Therapeutic Method
The capsule that the oral the present invention for the treatment of group obtains according to embodiment 3, every day 3 times.Treat 1 month.
The oral loratadine 10mg of matched group, every day 1 time.Treat 1 month.
3, criterion of therapeutical effect and therapeutic outcome
3.1 criterion of therapeutical effect
Observe sneeze before and after treatment, snivel, nasal obstruction, the improvement situation of the symptoms such as rhinocnesmus, all cases all adopt treatment cross-reference method.Recovery from illness: transference cure, toposcopy is shown in that nasal mucosa is normal, without recurrence in 1 year; Effective: rhinorrhea with clear discharge disappears, even sneeze, nasal obstruction, rhinocnesmus is alleviated; Take a turn for the better: sneeze reduces, and snivel alleviates, nasal obstruction, rhinocnesmus improves; Invalid: symptom is without improvement.
3.2 treatment statistical results are in table 1.
Table 1 liang group comparitive study
Visible, the medicine that the present invention obtains can safe and effective treatment of allergic rhinitis, and cure rate is high.
Detailed description of the invention
In order to understand better and implement the present invention, further illustrate the present invention below in conjunction with specific embodiment.
Embodiment 1
Take: the Rhizoma Atractylodis Macrocephalae 10 grams, 9 grams, Radix Glycyrrhizae, Fructus Lycii 15 grams, Bulbus Lilii 9 grams, Radix Ophiopogonis 8 grams, 3 grams, Folium Nelumbinis, Herba Asari 8 grams; Add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, is concentrated into 120 grams, must meet the decoct of adult normal's one day consumption.
Be used for the treatment of allergic rhinitis.Oral, daily once.
Embodiment 2
Take: the Rhizoma Atractylodis Macrocephalae 10 grams, 9 grams, Radix Glycyrrhizae, Fructus Lycii 15 grams, Bulbus Lilii 9 grams, Radix Ophiopogonis 8 grams, 3 grams, Folium Nelumbinis, Herba Asari 8 grams; Add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1.5 hours, filters; Merging filtrate, concentrated, dry, packaging, must meet the powder of adult normal's one day consumption.
Be used for the treatment of allergic rhinitis.Oral, every bu is taken for twice sooner or later.
Embodiment 3
Take: the Rhizoma Atractylodis Macrocephalae 10 grams, 9 grams, Radix Glycyrrhizae, Fructus Lycii 15 grams, Bulbus Lilii 9 grams, Radix Ophiopogonis 8 grams, 3 grams, Folium Nelumbinis, Herba Asari 8 grams; Add 6 times of water gagings, decoct 3 times, each decoction 1 hour, merges decoction liquor, concentrated, dry, incapsulates shell, must meet the capsule of adult normal's one day consumption.
Be used for the treatment of allergic rhinitis.Oral, every bu morning, noon and afternoon take for three times.

Claims (4)

1. be used for the treatment of a medicine for allergic rhinitis, it is characterized in that, it is prepared from by the raw medicinal material of following weight proportion: the Rhizoma Atractylodis Macrocephalae 10 parts, 9 parts, Radix Glycyrrhizae, Fructus Lycii 15 parts, Bulbus Lilii 9 parts, Radix Ophiopogonis 8 parts, 3 parts, Folium Nelumbinis, Herba Asari 8 parts.
2. a kind of medicine being used for the treatment of allergic rhinitis as claimed in claim 1, it is characterized in that, its preparation method is: take: the Rhizoma Atractylodis Macrocephalae 10 parts, 9 parts, Radix Glycyrrhizae, Fructus Lycii 15 parts, Bulbus Lilii 9 parts, Radix Ophiopogonis 8 parts, 3 parts, Folium Nelumbinis, Herba Asari 8 parts; Add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, is concentrated into 120 parts, obtains decoct; Above-mentioned part all refers to weight portion.
3. a kind of medicine being used for the treatment of allergic rhinitis as claimed in claim 1, it is characterized in that, its preparation method is: take: the Rhizoma Atractylodis Macrocephalae 10 parts, 9 parts, Radix Glycyrrhizae, Fructus Lycii 15 parts, Bulbus Lilii 9 parts, Radix Ophiopogonis 8 parts, 3 parts, Folium Nelumbinis, Herba Asari 8 parts; Add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1.5 hours, filters; Merging filtrate, concentrated, dry, packaging, obtains powder; Above-mentioned part all refers to weight portion.
4. a kind of medicine being used for the treatment of allergic rhinitis as claimed in claim 1, it is characterized in that, its preparation method is: take: the Rhizoma Atractylodis Macrocephalae 10 parts, 9 parts, Radix Glycyrrhizae, Fructus Lycii 15 parts, Bulbus Lilii 9 parts, Radix Ophiopogonis 8 parts, 3 parts, Folium Nelumbinis, Herba Asari 8 parts; Add 6 times of water gagings, decoct 3 times, each decoction 1 hour, merges decoction liquor, concentrated, dry, incapsulates shell, obtains capsule; Above-mentioned part all refers to weight portion.
CN201510776536.7A 2015-11-10 2015-11-10 Medicine for treating allergic rhinitis Pending CN105327110A (en)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101134095A (en) * 2006-08-29 2008-03-05 肖祖胜 Traditional Chinese medicine composition for treating allergic rhinitis
CN101698000A (en) * 2009-10-23 2010-04-28 张晓波 Traditional Chinese medicine for treating allergic rhinitis
CN103736072A (en) * 2014-01-28 2014-04-23 张怀胜 Medicament for treating allergic rhinitis and preparation method of medicament
CN104840817A (en) * 2015-05-18 2015-08-19 西宁科进工业设计有限公司 Traditional Chinese medicine for treating allergic rhinitis

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101134095A (en) * 2006-08-29 2008-03-05 肖祖胜 Traditional Chinese medicine composition for treating allergic rhinitis
CN101698000A (en) * 2009-10-23 2010-04-28 张晓波 Traditional Chinese medicine for treating allergic rhinitis
CN103736072A (en) * 2014-01-28 2014-04-23 张怀胜 Medicament for treating allergic rhinitis and preparation method of medicament
CN104840817A (en) * 2015-05-18 2015-08-19 西宁科进工业设计有限公司 Traditional Chinese medicine for treating allergic rhinitis

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
吴朝晖: ""蔡氏抗敏鼻炎方治疗过敏性鼻炎35例"", 《安徽中医临床杂志》 *
谢水祥等: ""变应性鼻炎的病因病机及辨证论治"", 《时珍国医国药》 *

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