CN105326921A - Traditional Chinese medicine paste patch applied to irregular menstruation of gynecology and preparation method - Google Patents

Traditional Chinese medicine paste patch applied to irregular menstruation of gynecology and preparation method Download PDF

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CN105326921A
CN105326921A CN201510914519.5A CN201510914519A CN105326921A CN 105326921 A CN105326921 A CN 105326921A CN 201510914519 A CN201510914519 A CN 201510914519A CN 105326921 A CN105326921 A CN 105326921A
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parts
chinese medicine
radix
patch
irregular menstruation
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王金国
周培林
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/235Foeniculum (fennel)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/07Basidiomycota, e.g. Cryptococcus
    • A61K36/076Poria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282Artemisia, e.g. wormwood or sagebrush
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284Atractylodes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/285Aucklandia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286Carthamus (distaff thistle)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/34Campanulaceae (Bellflower family)
    • A61K36/344Codonopsis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/46Eucommiaceae (Eucommia family), e.g. hardy rubber tree
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/533Leonurus (motherwort)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/54Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/66Papaveraceae (Poppy family), e.g. bloodroot
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023Transdermal patches and similar drug-containing composite devices, e.g. cataplasms

Abstract

The invention discloses a traditional Chinese medicine paste patch applied to irregular menstruation of gynecology and a preparation method. The traditional Chinese medicine paste patch is prepared from, by weight, 25-35 parts of fennel, 100-300 parts of leonurus, 40-80 parts of codonopsis pilosula, 40-60 parts of radix paeoniae alba, 40-60 parts of safflower carthamus, 40-60 parts of poria with hostwood, 40-60 parts of teasel roots, 25-35 parts of rhizoma corydalis, 15-25 parts of folium artemisiae argyi, 15-25 parts of herba lycopi, 25-35 parts of eucommia ulmoides, 15-25 parts of rhizoma atractylodis macrocephalae, 15-25 parts of akebiaquinata, 15-25 parts of elecampane and 15-25 parts of Chinese cinnamon. The traditional Chinese medicine paste patch prepared through the preparation method and the preparation method have the advantages that the paste patch effectively treats symptoms of cold in uterus, irregular menstruation, lochia, abdominal pain and the like; the curative effect is definite, homology of medicine and food is achieved, external use is convenient, no side effect exists, the preparation method is simple, ingredients are stable, and the traditional Chinese medicine paste patch has great social benefits and economic benefits.

Description

A kind of Chinese medicine patch and preparation method being applied to gynecological's irregular menstruation
Technical field
The present invention relates to external application Chinese medicine patch, especially provide a kind of the Chinese medicine patch and the preparation method that are applied to gynecological's irregular menstruation.
Background technology
Irregular menstruation belongs to common gynecological disease, shows as the exception of menstrual cycle or amount of bleeding, or the moon is premenstrual, menstrual period time stomachache and General Symptoms.The cause of disease may be organic disease or malfunction.Due to " married woman only through water for educating the phase of heir, irregular menstruation, namely non-become pregnant million.Even if by it, also not the whole America." add that irregular menstruation itself is to the many discomforts on the body and mind that brings of patient, therefore pole is necessary to treat this.Domestic and international at present to gynopathic treatment, there are the following problems: general health product weak curative effect, and Western medicine function singleness, can not play treating both the principal and secondary aspects of a disease effect; Large benefit of part herbal species system and so on, the suitable crowd taken is few, and destructible internal organs QI and blood balance.The medicament categories of existing treatment irregular menstruation is various, but polygamy side is complicated, and specific aim is poor, therapeutic effect is not good enough, majority is all oral is principal agent thing prevention and therapy, and external patch product is at present few on the market, the present invention release Chinese medicinal ointment stick foot clinical in the urgent need to, the present invention is applied to gynecological's irregular menstruation Be very effective through clinical trial Chinese medicine patch, has vast promotional value.
Summary of the invention
The object of the present invention is to provide a kind of can the Chinese medicine patch that uses of external, and it effectively treats cold uterus, the diseases such as irregular menstruation, lochia, stomachache; Determined curative effect, and medicated diet homology, external is convenient, and a kind of Chinese medicine patch and the preparation method being applied to gynecological's irregular menstruation had no side effect, meets the problem that above-mentioned background technology proposes.
To achieve these goals, the invention provides following technical scheme:
A kind of Chinese medicine patch being applied to gynecological's irregular menstruation of the present invention, it is mixed with by the raw material of Chinese medicine of following weight parts: Fructus Foeniculi 25 ~ 35 parts, Herba Leonuri 100 ~ 300 parts, Radix Codonopsis 40 ~ 80 parts, the Radix Paeoniae Alba 40 ~ 60 parts, 40 ~ 60 parts, Flos Carthami, Poria cum Radix Pini 40 ~ 60 parts, Radix Dipsaci 40 ~ 60 parts, Rhizoma Corydalis 25 ~ 35 parts, Folium Artemisiae Argyi 15 ~ 25 parts, Herba Lycopi 15 ~ 25 parts, the Cortex Eucommiae 25 ~ 35 parts, the Rhizoma Atractylodis Macrocephalae 15 ~ 25 parts, Caulis Akebiae 15 ~ 25 parts, the Radix Aucklandiae 15 ~ 25 parts, Cortex Cinnamomi 15 ~ 25 parts.
As the further scheme of the present invention: preferred to be mixed with by the raw material of Chinese medicine of following weight parts: Fructus Foeniculi 25 parts, Herba Leonuri 200 parts, Radix Codonopsis 50 parts, the Radix Paeoniae Alba 50 parts, 50 parts, Flos Carthami, Poria cum Radix Pini 50 parts, Radix Dipsaci 50 parts, Rhizoma Corydalis 25 parts, Folium Artemisiae Argyi 15 parts, Herba Lycopi 18 parts, the Cortex Eucommiae 25 parts, the Rhizoma Atractylodis Macrocephalae 20 parts, Caulis Akebiae 20 parts, the Radix Aucklandiae 20 parts, Cortex Cinnamomi 20 parts.
Medical material used in the present invention has following characteristic:
Fructus Foeniculi: [English name] FRUCTUSFOENICULI, [source] this product is the dry mature fruit of samphire Fructus Foeniculi FoeniculumvulgareMill.; Its root, leaf and herb are also pharmaceutically acceptable.[nature and flavor] are pungent, temperature.[return through] returns liver,kidney,spleen, stomach warp.[function cures mainly] dispersing cold for relieving pain, regulating qi-flowing for harmonizing stomach.
Herba Leonuri: [another name] Herba Leonuri Artemisia, Herba Leonuri Chinese mugwort, Flos Carthami Chinese mugwort, Herba Leonuri, motherwort, triangle linseed, four stupefied sons [source] this product are the fresh or dry aerial parts of labiate Herba Leonuri LeonurusjaponicusHoutt..[nature and flavor] are bitter, pungent, are slightly cold.[return through] returns liver, pericardium channel.[function cures mainly] promoting blood flow to regulate menstruation, inducing diuresis to remove edema.For menoxenia, dysmenorrhea, amenorrhea, lochiorrhea, edema oliguria; Acute nephritis edema.
Radix Codonopsis: [English name] RADIXCODONOPSIS[calls] eastern party, platform party, the Lushui River party, mouth party [source] this product be Campanulaceae Radix Codonopsis Codonopsispilosula(Franch.) Nannf., element flower Radix Codonopsis (RADIX CODONOPSIS PILOSULAE from Northwest of China) CodonopsispilosulaNannf.var.modesta(Nannf.) dry root of L.T.Shen or radix codonpsis tangshen CodonopsistangshenOliv..[nature and flavor] are sweet, flat.[return through] returns spleen, lung meridian.[function cures mainly] invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst.
The Radix Paeoniae Alba: [another name] Radix Paeoniae [source] this product is the dry root of ranunculaceae plant Radix Paeoniae PaeonialactifloraPall..[nature and flavor] are bitter, sour, are slightly cold.[return through] returns liver, spleen channel.The pain relieving of [function cures mainly] suppressing the hyperactive liver, nourishing blood for regulating menstruation, astringing YIN to stop sweating.[extracts] " Chinese Pharmacopoeia ".
Flos Carthami: [another name] Flos Carthami [source] this product is the dried floral of feverfew Flos Carthami CarthamustinctoriusL..[nature and flavor] are pungent, temperature.[return through] GUIXIN, Liver Channel.[function cures mainly] promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, injury from falling down, skin infection swells and ache.
Poria cum Radix Pini: [another name] Lignum Poria [source] Poria cum Radix Pini: in the middle of poria cocos sclerotium, (Poria) entertains the part of Radix Pini massonianae or fine core person.[nature and flavor] are sweet, flat.[function cures mainly] mind tranquilizing and the heart calming.Be applicable to the disease such as severe palpitation, insomnia forgetfulness.
Radix Dipsaci: [another name] Radix Dipsaci, shaven head, chervil [source] this product are Dipsacaceae plant Radix Dipsaci DipsacusasperoidesC.Y.ChengetT.M.Ai(or DipsacusasperWall) dry root.[nature and flavor] are bitter, pungent, tepor.[return through] returns liver, kidney channel.[function cures mainly] invigorating the liver and kidney, bone and muscle strengthening, continuous injured, only metrorrhagia.
Rhizoma Corydalis: Rhizoma Corydalis has another name called Rhizoma Corydalis, Rhizoma Corydalis, Rhizoma Corydalis, CorydalisyanhusuoW.T.WangexZ.Y.SuetC.Y.Wu.Papaveraceae corydalisperennial herb.[nature and flavor] are pungent, bitter, temperature, GUIXIN, liver, spleen channel.[function cures mainly] blood-activating and qi-promoting, pain relieving again.
Folium Artemisiae Argyi: [another name] Chinese mugwort, Radix Artemisia ordosicae, family's Chinese mugwort [source] this product are that feverfew ends the dried leaves of ArtemisiaargyiLevl.etVant..[nature and flavor] are pungent, bitter, temperature; Slightly poisonous.[return through] returns liver,spleen,kidney warp.[function cures mainly] dispersing cold for relieving pain, warming the meridian for stopping bleeding.For few abdomen cold type of pain, coldness and unbalance in meridians, cold womb is infertile, spit blood, epistaxis, metrorrhagia through many, gestation hemorrhage; External treatment skin pruritus.
Herba Lycopi: [another name] lycopus lucidus, Rhizoma Lycopi Lucidi, Chinese artichoke, side obstruct the dry aerial parts that Herba Lycopi [source] this product is labiate hair leaf lycopus lucidus LycopuslucidusTurcz.var.hirtusRegel.[nature and flavor] are bitter, pungent, tepor.[return through] returns liver, spleen channel.[function cures mainly] blood circulation promoting and blood stasis dispelling, line water detumescence.For menoxenia, amenorrhea, dysmenorrhea, postnatal blood stasis is suffered from abdominal pain, edema.
The Cortex Eucommiae: the dry bark that [another name] pulls a skin, thinks the second month in a season, silk flosssilk wadding skin, beautiful silk skin [source] this product are Eucommiaceae plant Cortex Eucommiae EucommiaulmoidesOliv..[nature and flavor] are sweet, temperature.[return through] returns liver, kidney channel.[function cures mainly] invigorating the liver and kidney, bone and muscle strengthening, antiabortive.
The Rhizoma Atractylodis Macrocephalae: [another name] Rhizoma Atractylodis Macrocephalae, winter art, Zhejiang art, kind art [source] this product are the dry rhizome of feverfew Rhizoma Atractylodis Macrocephalae AtractylodesmacrocephalaKoidz..[nature and flavor] are bitter, sweet, temperature.[return through] returns spleen, stomach warp.[function cures mainly] invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.
Caulis Akebiae: [another name] Medulla Tetrapanacis, attached (" herbal classic "), fourth father-in-law (" wU Pu Bencao"), Caulis et Folium piperis (" extensively refined "), Weed rattan (" collective Notes to Canon of Materia Medica"), king father-in-law, Wan Nian, 10000 years rattans (" property of medicine opinion "), swallow Fu, black Fu (Tang Materia Medica).[source] is plants of Lardizabalaceae Caulis Akebiae or threeleaf akebia, the woody stems of Caulis Akebiae.[nature and flavor] are bitter, cool.1. " herbal classic ": " acrid in the mouth is flat." [return through] enters the heart, small intestinal, urinary bladder channel.[function cures mainly] pathogenic fire purging row water, promoting blood circulation.
The Radix Aucklandiae: [source] this product is the dry root of feverfew Radix Aucklandiae AucklandialappaDecne..[nature and flavor] are pungent, bitter, temperature.[return through] returns spleen, stomach, large intestine, three burnt, gallbladder meridians.[function cures mainly] promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion.
Cortex Cinnamomi: [property of medicine] extremely hot in nature, acrid-sweet flavor, slightly poisonous.[effect] warming the spleen and stomach, dispersing wind and cold, promoting blood circulation.Control the cold fullness in the chest of abdomen, vomit dysphagic, rheumatic arthralgia, fall damage the stasis of blood stagnant, dysentery hemorrhoidal hamorrhage.
The present invention also provides the preparation method of above-mentioned Chinese medicine patch, and people adopt the method known to comprise the steps: usually in the art
1) each parts by weight of raw materials of following Chinese medicine is taken: Fructus Foeniculi 25 ~ 35 parts, Herba Leonuri 100 ~ 300 parts, Radix Codonopsis 40 ~ 80 parts, the Radix Paeoniae Alba 40 ~ 60 parts, 40 ~ 60 parts, Flos Carthami, Poria cum Radix Pini 40 ~ 60 parts, Radix Dipsaci 40 ~ 60 parts, Rhizoma Corydalis 25 ~ 35 parts, Folium Artemisiae Argyi 15 ~ 25 parts, Herba Lycopi 15 ~ 25 parts, the Cortex Eucommiae 25 ~ 35 parts, the Rhizoma Atractylodis Macrocephalae 15 ~ 25 parts, Caulis Akebiae 15 ~ 25 parts, the Radix Aucklandiae 15 ~ 25 parts, Cortex Cinnamomi 15 ~ 25 parts;
2) pot low baking temperature parching to brown is put into by after above-mentioned whole pulverizing medicinal materials, add medicine gross mass 3-5 Oleum Sesami doubly, slow fire is warmed to 300 degree, stir and within 10-20 minute, make raw material of Chinese medicine full and uniform to black plaster shape in Oleum sesami, after airing, plaster spreads upon on Medical adhesive plaster, often open Medical adhesive plaster calculate 1 paste, (plaster account for size in long 6cm*4cm for), obtain patch.
Using method: often paste available 7 days, changes 1 subsides for every 7 days.2 paste 1 course for the treatment of.Untoward reaction: everyone skin properties is different, and Chinese medicine patch collection of the present invention tens kinds of Chinese medicine ingredients, mainly on external application patient skin, there will not be phenomena of cutaneous irritation usually; If phenomena of cutaneous irritation appears in patient, there is red point or numb sensation, need not be alarmed, raise patch and be coated with the Oleum sesami of ordering on skin, then apply this patch after 0.5-1 hour allergic phenomena just can disappear; Different according to conditions of patients degree, general patient's external application 1 ~ 2 course for the treatment of (2 paste-4 pastes) just can rehabilitation, and as heavy patient often accompanies irregular menstruation person for many years, general external application 2 ~ 4 courses for the treatment of (4 paste-8 pastes) just can be fully recovered.
beneficial effect
The advantage of Chinese medicine patch of the present invention is:
(1) provide a kind of Chinese medicine patch being applied to gynecological's irregular menstruation, add clinical application kind, meet clinical needs.
(2) Chinese medicine patch antithetical phrase cold womb of the present invention is cold, the diseases such as irregular menstruation, lochia, stomachache, etc. having quick opsonic action, clinical verification shows irregular menstruation Be very effective in Chinese medicine patch Zhuan Zhi gynecological of the present invention, and Chinese medicine curative effect that patch reaches of the present invention is that those of ordinary skill in the art are beyond thought.
(3) Chinese medicine patch determined curative effect of the present invention, and medicated diet homology, external is convenient, and the advantage such as have no side effect, and preparation technology is simple, and between different batches medicine, mass discrepancy is little, and drug quality is uniform and stable, has vast Social benefit and economic benefit.
The therapeutic effect of Chinese medicine patch of the present invention is set forth further below by way of clinical observation on the therapeutic effect.
1, physical data
Inventor in March, 2012 ~ 2014 collect menoxenia patient 120 example of outpatient clinic altogether between year March, all meet menoxenia diagnostic criteria.Wherein, 16 ~ 55 years old age, average 31.5 years old; More than the course of disease 2 months ~ December, menstruation 7 ~ 21d in menstrual period, average 14d.All patients are divided at random treatment group 60 example and matched group 60 example.The aspects such as two groups of patient ages, the course of disease, state of an illness compare, and no significant difference, has comparability.
2, test method
Treatment group uses Chinese medicine patch of the present invention often to paste available 7 days, within every 7 days, changes 1 subsides, and 2 paste 1 course for the treatment of, the course for the treatment of: 2 months.
Matched group adopts wUJI BAIFENG WAN(Jiangxi medicine all renhepharmaceutical Co. Ltd) oral (using according to its description), oral, warm yellow wine or warm water delivery service, water-honeyed pill one time 6 grams, big honeyed pills 1 ball, 2 times on the one, 2 months courses for the treatment of.
All patients treatments period monthly follows up a case by regular visits to 1 time, carries out curative effect statistics after 2 months, continues observation 1 month after effective person's drug withdrawal, observes menstruation.
3, criterion of therapeutical effect and therapeutic outcome
Criterion of therapeutical effect is drafted with reference to " Chinese medical disease clinical efficacy standard ":
Effective: after treatment, menstrual cycle returns to (28 ± 7) d, through amount, recover normal through color, menstrual period≤7d, anemia is improved, clinical symptom disappearance or substantially disappear;
Effective: menstrual cycle has larger improvement before comparatively treating, through amount, normal through color, menstrual period≤7d, anemia is improved, and clinical symptoms takes a turn for the better to some extent;
Invalid: treatment after menstrual cycle still abnormal, through amount without reduce or increase, normal or abnormal through color, menstrual period > 7d, clinical symptoms without improvement or increase the weight of.
4, therapeutic outcome
Table 1 liang group Clinical efficacy comparison:
Visible Chinese medicine patch of the present invention is used for the treatment of irregular menstruation and has determined curative effect, and medicated diet homology, external is convenient, has no side effect, has the value applied.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is described in detail, but the present invention is not limited to specific embodiment.
embodiment 1
Raw material: Fructus Foeniculi 25 parts, Herba Leonuri 200 parts, Radix Codonopsis 50 parts, the Radix Paeoniae Alba 50 parts, 50 parts, Flos Carthami, Poria cum Radix Pini 50 parts, Radix Dipsaci 50 parts, Rhizoma Corydalis 25 parts, Folium Artemisiae Argyi 15 parts, Herba Lycopi 18 parts, the Cortex Eucommiae 25 parts, the Rhizoma Atractylodis Macrocephalae 20 parts, Caulis Akebiae 20 parts, the Radix Aucklandiae 20 parts, Cortex Cinnamomi 20 parts.
Preparation:
1) each parts by weight of raw materials of following Chinese medicine is taken: Fructus Foeniculi 25 parts, Herba Leonuri 200 parts, Radix Codonopsis 50 parts, the Radix Paeoniae Alba 50 parts, 50 parts, Flos Carthami, Poria cum Radix Pini 50 parts, Radix Dipsaci 50 parts, Rhizoma Corydalis 25 parts, Folium Artemisiae Argyi 15 parts, Herba Lycopi 18 parts, the Cortex Eucommiae 25 parts, the Rhizoma Atractylodis Macrocephalae 20 parts, Caulis Akebiae 20 parts, the Radix Aucklandiae 20 parts, Cortex Cinnamomi 20 parts;
2) pot low baking temperature parching to brown is put into by after above-mentioned whole pulverizing medicinal materials, add medicine gross mass 3-5 Oleum Sesami doubly, slow fire is warmed to 300 degree, stir and within 10-20 minute, make raw material of Chinese medicine full and uniform to black plaster shape in Oleum sesami, after airing, plaster spreads upon on Medical adhesive plaster, often open Medical adhesive plaster calculate 1 paste, (plaster account for size in long 6cm*4cm for), obtain patch.
Using method: often paste available 7 days, changes 1 subsides for every 7 days.2 paste 1 course for the treatment of.Untoward reaction: everyone skin properties is different, and Chinese medicine patch collection of the present invention tens kinds of Chinese medicine ingredients, mainly on external application patient skin, there will not be phenomena of cutaneous irritation usually; If phenomena of cutaneous irritation appears in patient, there is red point or numb sensation, need not be alarmed, raise patch and be coated with the Oleum sesami of ordering on skin, then apply this patch after 0.5-1 hour allergic phenomena just can disappear; Different according to conditions of patients degree, general patient's external application 1 ~ 2 course for the treatment of (2 paste-4 pastes) just can rehabilitation, and as heavy patient often accompanies irregular menstruation person for many years, general external application 2 ~ 4 courses for the treatment of (4 paste-8 pastes) just can be fully recovered.
embodiment 2
Raw material: Fructus Foeniculi 35 parts, Herba Leonuri 250 parts, Radix Codonopsis 80 parts, the Radix Paeoniae Alba 60 parts, 60 parts, Flos Carthami, Poria cum Radix Pini 60 parts, Radix Dipsaci 60 parts, Rhizoma Corydalis 35 parts, Folium Artemisiae Argyi 25 parts, Herba Lycopi 25 parts, the Cortex Eucommiae 35 parts, the Rhizoma Atractylodis Macrocephalae 25 parts, Caulis Akebiae 25 parts, the Radix Aucklandiae 25 parts, Cortex Cinnamomi 25 parts.
Prepare identical with embodiment 1 with using method.
embodiment 3
Raw material: Fructus Foeniculi 25 parts, Herba Leonuri 100 parts, Radix Codonopsis 40 parts, the Radix Paeoniae Alba 40 parts, 40 parts, Flos Carthami, Poria cum Radix Pini 40 parts, Radix Dipsaci 40 parts, Rhizoma Corydalis 25 parts, Folium Artemisiae Argyi 15 parts, Herba Lycopi 15 parts, the Cortex Eucommiae 25 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, Caulis Akebiae 15 parts, the Radix Aucklandiae 15 parts, Cortex Cinnamomi 15 parts.
Prepare identical with embodiment 1 with using method.
model case
Case 1 Mrs Wang, 36 years old, Wenzhou District of Zhejiang Province people from urban district, [main suit] nearly menstruation does not over the past half year postpone 11 days 2 months not etc., and [history of present illness] over the past half year menstruation is postponed, and amount is few, time menstrual period duration (grow to take medication just only) short (4 days), menstrual period hurt like hell, sitting is unbearable, pale complexion, extremity are ice-cold, nervous, breathe hard, cold perspiration, often takes analgesic.[having a medical check-up] 80, R19T36.5BP80/60mmHg, form is slightly fat, the visible ecchymosis of skin after tired (can from silk ribbon attached to an official seal or a medal solution), whole body does not touch lymph node, and lung auscultation is normal, the rhythm of the heart is slightly uneven, receive normal, urine can, have slight constipation (lacking exercise), bring into use Chinese medicine patch of the present invention afterwards, within every 7 days, change 1 subsides, often paste available 7 days, 2 paste 1 course for the treatment of.After 3 courses for the treatment of, dysmenorrhea symptom obviously alleviates, and after continuing to strengthen 2 courses for the treatment of of use, returns to one's perfect health.
Case 2 Mrs Qiao, 25 years old, Zhejiang Hangzhou people, [main suit] to have a surplus, accompanies low grade fever to be admitted to hospital January because of irregular menstruation half a year.There is menoxenia without obvious inducement in [history of present illness] patient, menstrual blood volume reduces gradually before half a year, diarrhoea, feels sick, weak, pale complexion, extremity are ice-cold, nervous, breathe hard, had a strong impact on the health of work and health, occurred amenorrhea afterwards, companion is afternoon, Sleep hyperhidrosis, non-row diagnosis and treatment.Began to occur low grade fever before 1 month, body temperature fluctuation is between 37.2-38 DEG C.Patient brings into use Chinese medicine patch of the present invention afterwards, within every 7 days, changes 1 subsides, often pastes available 7 days, and 2 paste 1 course for the treatment of.After 3 courses for the treatment of, dysmenorrhea symptom obviously alleviates, and after continuing to strengthen 3 courses for the treatment of of use, cures completely, and electricity is visited and had no recurrence.
Case 3 Mrs Wang, 40 years old, patient main suit: over nearest 1 year normal about 1 month sometimes, when coming, the cycle also shortened for 1 week.Patient feels that extremity are afraid of cold, and have sweating during the palm of the hand usually, but very serious, and waist occasionally has aches, and waist is afraid of cold winter.Shi Youtou is vexed, cardiopalmus, impatient.Receive dormancy can, usually like sweet food.[menstrual history] menstruation comes just to measure seldom for 15 years old always, and frequent incessantly dripping, and the eumenorrhea after a while afterwards, in menstruations, four, five in nearly are abnormal again, and within one month, only had for 1 week do not come, other times are all incessantly dripping, Chinese medicine also to be taken a lot of, does not also get better always.Patient selects Chinese medicine patch of the present invention within every 7 days, to change 1 subsides afterwards, often pastes available 7 days, and 2 paste 1 course for the treatment of.After 4 courses for the treatment of, dysmenorrhea symptom obviously alleviates, and cures after continuing to strengthen 3 courses for the treatment of of use, and patient's incoming call says that menstrual cycle is normal happily in recent years.

Claims (3)

1. one kind is applied to the Chinese medicine patch of gynecological's irregular menstruation, it is characterized in that, it is mixed with by the raw material of Chinese medicine of following weight parts: Fructus Foeniculi 25 ~ 35 parts, Herba Leonuri 100 ~ 300 parts, Radix Codonopsis 40 ~ 80 parts, the Radix Paeoniae Alba 40 ~ 60 parts, 40 ~ 60 parts, Flos Carthami, Poria cum Radix Pini 40 ~ 60 parts, Radix Dipsaci 40 ~ 60 parts, Rhizoma Corydalis 25 ~ 35 parts, Folium Artemisiae Argyi 15 ~ 25 parts, Herba Lycopi 15 ~ 25 parts, the Cortex Eucommiae 25 ~ 35 parts, the Rhizoma Atractylodis Macrocephalae 15 ~ 25 parts, Caulis Akebiae 15 ~ 25 parts, the Radix Aucklandiae 15 ~ 25 parts, Cortex Cinnamomi 15 ~ 25 parts.
2. a kind of Chinese medicine patch being applied to gynecological's irregular menstruation according to claim 1, it is characterized in that, it is mixed with by the raw material of Chinese medicine of following weight parts: Fructus Foeniculi 25 parts, Herba Leonuri 200 parts, Radix Codonopsis 50 parts, the Radix Paeoniae Alba 50 parts, 50 parts, Flos Carthami, Poria cum Radix Pini 50 parts, Radix Dipsaci 50 parts, Rhizoma Corydalis 25 parts, Folium Artemisiae Argyi 15 parts, Herba Lycopi 18 parts, the Cortex Eucommiae 25 parts, the Rhizoma Atractylodis Macrocephalae 20 parts, Caulis Akebiae 20 parts, the Radix Aucklandiae 20 parts, Cortex Cinnamomi 20 parts.
3. a kind of preparation method being applied to the Chinese medicine patch of gynecological's irregular menstruation according to claim 1, is characterized in that the method comprises the steps:
1) each parts by weight of raw materials of following Chinese medicine is taken: Fructus Foeniculi 25 ~ 35 parts, Herba Leonuri 100 ~ 300 parts, Radix Codonopsis 40 ~ 80 parts, the Radix Paeoniae Alba 40 ~ 60 parts, 40 ~ 60 parts, Flos Carthami, Poria cum Radix Pini 40 ~ 60 parts, Radix Dipsaci 40 ~ 60 parts, Rhizoma Corydalis 25 ~ 35 parts, Folium Artemisiae Argyi 15 ~ 25 parts, Herba Lycopi 15 ~ 25 parts, the Cortex Eucommiae 25 ~ 35 parts, the Rhizoma Atractylodis Macrocephalae 15 ~ 25 parts, Caulis Akebiae 15 ~ 25 parts, the Radix Aucklandiae 15 ~ 25 parts, Cortex Cinnamomi 15 ~ 25 parts;
2) pot low baking temperature parching to brown is put into by after above-mentioned whole pulverizing medicinal materials, add medicine gross mass 3-5 Oleum Sesami doubly, slow fire is warmed to 300 degree, stir and within 10-20 minute, make raw material of Chinese medicine full and uniform to black plaster shape in Oleum sesami, after airing, plaster spreads upon on Medical adhesive plaster, often open Medical adhesive plaster calculate 1 paste, (plaster account for size in long 6cm*4cm for), obtain patch.
CN201510914519.5A 2015-12-13 2015-12-13 Traditional Chinese medicine paste patch applied to irregular menstruation of gynecology and preparation method Withdrawn CN105326921A (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103341004A (en) * 2013-06-27 2013-10-09 柳晖 Chinese medicine composition for treating delayed menstrual cycle
CN104107318A (en) * 2014-03-08 2014-10-22 毕玉珍 Traditional Chinese medicinal composition for treating blood stasis stagnation type irregular menstruation
CN104173565A (en) * 2014-08-25 2014-12-03 赵红丽 Traditional Chinese medicine composition for treating irregular menstruation

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Publication number Priority date Publication date Assignee Title
CN103341004A (en) * 2013-06-27 2013-10-09 柳晖 Chinese medicine composition for treating delayed menstrual cycle
CN104107318A (en) * 2014-03-08 2014-10-22 毕玉珍 Traditional Chinese medicinal composition for treating blood stasis stagnation type irregular menstruation
CN104173565A (en) * 2014-08-25 2014-12-03 赵红丽 Traditional Chinese medicine composition for treating irregular menstruation

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Application publication date: 20160217