CN105289308A - Equipment for traditional Chinese medicine purification and applications thereof - Google Patents
Equipment for traditional Chinese medicine purification and applications thereof Download PDFInfo
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- CN105289308A CN105289308A CN201510808847.7A CN201510808847A CN105289308A CN 105289308 A CN105289308 A CN 105289308A CN 201510808847 A CN201510808847 A CN 201510808847A CN 105289308 A CN105289308 A CN 105289308A
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- 239000003814 drug Substances 0.000 title claims abstract description 67
- 238000000746 purification Methods 0.000 title claims abstract description 35
- 238000001223 reverse osmosis Methods 0.000 claims abstract description 43
- 239000012528 membrane Substances 0.000 claims abstract description 19
- 238000003860 storage Methods 0.000 claims abstract description 11
- 239000007788 liquid Substances 0.000 claims description 72
- 238000000108 ultra-filtration Methods 0.000 claims description 26
- 238000001914 filtration Methods 0.000 claims description 15
- 238000010438 heat treatment Methods 0.000 claims description 7
- 238000010790 dilution Methods 0.000 claims description 5
- 238000001816 cooling Methods 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 239000012535 impurity Substances 0.000 abstract description 4
- 239000012141 concentrate Substances 0.000 abstract description 3
- 230000000875 corresponding Effects 0.000 abstract description 2
- 239000002245 particle Substances 0.000 abstract description 2
- 239000011148 porous material Substances 0.000 abstract 1
- 238000001764 infiltration Methods 0.000 description 6
- 239000004480 active ingredient Substances 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 238000011084 recovery Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 238000009835 boiling Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 238000000638 solvent extraction Methods 0.000 description 2
- 230000000844 anti-bacterial Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 238000004134 energy conservation Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000006011 modification reaction Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000001256 steam distillation Methods 0.000 description 1
- 230000001954 sterilising Effects 0.000 description 1
Abstract
The invention provides equipment for traditional Chinese medicine purification. The equipment comprises the following devices, which are connected in sequence through pipelines: a diluted medicinal liquor storage tank, a booster pump, a security filter, an ultrafilter device, a transfer pot, a high pressure pump, a reverse osmosis device, and a storage tank. The ultrafilter device comprises a membrane shell and an ultrafilter membrane. The ultrafilter device is provided with a first outlet and a second outlet; the first outlet is communicated with the transfer pot; the second outlet is connected to the inlet of the diluted medicinal liquor storage tank; the ultrafilter membrane is arranged in the membrane shell; and the pore size of the ultrafilter membrane is in a range of 0.001 to 0.1 [mu]m. Compared with the prior art, the large-particle impurities in diluted medicinal liquor is filtered and removed by the security filter, then corresponding ultrafilter membrane is selected according to the size of needed components in diluted medicinal liquor, thus the unneeded components in diluted medicinal liquor can be removed, then the needed components are subjected to reverse osmosis, and finally the concentrate is collected. If the required concentration is very high, the condensed medicinal liquor can be processed by the reverse osmosis device for several times to obtain the required traditional Chinese medicine.
Description
Technical field
The present invention relates to Chinese traditional medicine purification technology, specifically a kind of equipment of Chinese traditional medicine purification and application thereof.
Background technology
Along with the progress of society, more to the research of membrane separation technique in the world, this is because it has the features such as energy-conservation, efficient, easy to operate, so be more and more subject to the attention of researcher, and people more and more pay close attention to the effect of cleaner production and importance, government also increases the strict control dynamics of cleaner production.
Extraction process-water-boiling method traditional in traditional Chinese medicine extraction, solvent extraction method, steam distillation, circumfluence method are the methods that present people commonly use, wherein the water-boiling method time is long, consumes energy high, and active ingredient impurity is more, dissolution rate is relatively assorted, and non-final active ingredient.Each operation of solvent extraction method, the way of distillation needs very high heat energy, and filters, after cold heavy, sterilizing, because the heat time is long, often occurs flocculent deposit.So the content of economize energy, raising active ingredient is the direction of current traditional Chinese medicine extraction development.
Summary of the invention
The object of the invention is to solve that the power consumption of traditional Chinese medicine method of purification in prior art is high, effective agent loss large, the defect of poor product quality, providing a kind of equipment for Chinese traditional medicine purification and application thereof to solve the problems referred to above.
The present invention is achieved through the following technical solutions above-mentioned technical purpose:
For an equipment for Chinese traditional medicine purification, described equipment comprises the dilute liquid medicine holding vessel, booster pump, cartridge filter, ultrafiltration apparatus, transfer tank, high-pressure pump, reverse osmosis unit, the storage tank that are communicated with by the road successively; Described ultrafiltration apparatus comprises putamina and milipore filter; Described milipore filter is in putamina; The aperture of described milipore filter is 0.1 μm ~ 0.001 μm; Described ultrafiltration apparatus has the first outlet and the second outlet; Described first outlet is communicated with described transfer tank; Described second outlet is connected with the import of described dilute liquid medicine holding vessel.
Preferably, the aperture of described milipore filter is 0.001 μm.
Preferably, described cartridge filter comprises security personnel's filter membrane; The aperture of described security personnel's filter membrane is 0.22 μm.
Preferably, described reverse osmosis unit comprises reverse osmosis membrane; The aperture of described reverse osmosis membrane is 0.0001 μm.
Preferably, described reverse osmosis unit is first-stage reverse osmosis device or second level reverse osmosis apparatus.
Apply the method that above-mentioned a kind of equipment for Chinese traditional medicine purification carries out Chinese traditional medicine purification, comprise the following steps:
A. liquid dilution: add water heating dilute liquid medicine;
B. cool: to the liquid cooling after heating dilution;
C. essence filter: adopt cartridge filter tentatively to filter liquid;
D. ultrafiltration: the liquid filtered through cartridge filter in step c forms first order purification liquid and coarse filtration liquid after ultrafiltration apparatus filters;
E. osmosis filtration: the first order purification liquid in steps d enters reverse osmosis unit by described first outlet.
Preferably, in described step a, the temperature of dilute liquid medicine is 80 DEG C.
Preferably, in described step b, liquid is cooled to 40 DEG C.
Preferably, the coarse filtration liquid described in described steps d returns described dilute liquid medicine storage tank by described second outlet.
The present invention compared with prior art, has following beneficial effect:
1. the large granular impurity of its removing dilute liquid medicine inside is first filtered with security personnel, then corresponding milipore filter is selected according to the particle aperture of medicine liquid ingredient required in dilute liquid medicine, remove unwanted composition in dilute liquid medicine, the composition of needs is being got its concentrate warp through counter-infiltration.If according to its demand repeatedly through reverse osmosis unit, thus the Chinese medicine required for us can be reached when the concentration requirement of required concentrated medicament is too high;
2. after ultrafiltration, still contain mass efficient element in remaining coarse filtration liquid, so be communicated with dilute liquid medicine storage tank by ultrafiltration apparatus, make coarse filtration liquid return dilute liquid medicine storage tank, again through ultrafiltration apparatus, thus reach the recovery rate that medicament is provided.
Accompanying drawing explanation
Fig. 1 is the overall structure schematic diagram of a kind of equipment for Chinese traditional medicine purification of the present invention;
The equipment that Fig. 2 provides for Fig. 1 is for the method flow diagram of Chinese traditional medicine purification.
Detailed description of the invention
For making to have a better understanding and awareness architectural feature of the present invention and effect of reaching, coordinating detailed description in order to preferred embodiment and accompanying drawing, being described as follows:
As shown in Figure 1, a kind of equipment for Chinese traditional medicine purification, equipment comprises the dilute liquid medicine holding vessel 1, booster pump 2, cartridge filter 3, ultrafiltration apparatus 4, transfer tank 5, high-pressure pump 6, reverse osmosis unit 7, the storage tank 8 that are communicated with by the road successively.
The filter core of cartridge filter 3 provided by the invention is foldable filter element, and its aperture is 0.22 μm, in order to the large granular impurity of filtering dilute liquid medicine inside.
Ultrafiltration apparatus 4 comprises putamina and milipore filter.The aperture of milipore filter is 0.1 μm ~ 0.001 μm.The aperture of milipore filter provided by the invention is 0.001 μm.In order to remove unwanted composition in dilute liquid medicine, the composition of needs is pumped in reverse osmosis unit 7 through high-pressure pump 6.
Reverse osmosis unit 7 according to the concentration requirement of concentrate, can be set to first-stage reverse osmosis or two-pass reverse osmosis, and reverse osmosis unit 7 comprises counter-infiltration main frame and high-pressure pump.If first-stage reverse osmosis, so only need a high-pressure pump, if two-pass reverse osmosis, then need two high-pressure pumps, under the cooperation of two high-pressure pumps, make liquid repeatedly through counter-infiltration main frame, thus reach required concentration.Counter-infiltration main frame comprises putamina and reverse osmosis membrane, and reverse osmosis membrane is in putamina, and the aperture of reverse osmosis membrane is 0.0001 μm.
In order to improve the recovery rate of medicament active ingredient, ultrafiltration apparatus 4 provided by the invention comprises the first outlet 41 and the second outlet 42, first outlet 41 is connected with reverse osmosis unit 7, second outlet 42 is connected with the import of dilute liquid medicine holding vessel 1, the first purification liquid after ultrafiltration apparatus 4 filters enters reverse osmosis unit 7 through the first outlet 41, coarse filtration liquid under being intercepted by ultrafiltration apparatus 4 returns dilute liquid medicine holding vessel 1 through the second outlet 42, second ultrafiltration is carried out, to improve the recovery rate of medicament after mixing with the dilute liquid medicine in tank.
As shown in Figure 2, for above-mentioned equipment, its method for Chinese traditional medicine purification comprises the following steps:
Step 1. liquid dilutes: add water heating dilute liquid medicine;
Step 2. is by the liquid cooling after heating dilution;
Step 3. essence filter: adopt cartridge filter tentatively to filter liquid;
Step 4. ultrafiltration: the liquid filtered through cartridge filter in step 3 forms first order purification liquid and coarse filtration liquid after ultrafiltration apparatus 4 filters;
Step 5. counter-infiltration: the first order purification liquid in step 4 carries out counter-infiltration through reverse osmosis unit and forms concentrated medicament.
Wherein, in step 1, the temperature of dilute liquid medicine is 80 DEG C.The high temperature of 80 DEG C be medicament fully water-soluble while, also play bactericidal action.
Because milipore filter, reverse osmosis membrane all have the specific temperature scope of application, so, need, by step 2, liquid is cooled to 40 DEG C.
The first purification liquid in step 4 enters in reverse osmosis unit 7 through the first outlet 41, coarse filtration liquid under being intercepted by ultrafiltration apparatus 4 returns dilute liquid medicine holding vessel 1 through the second outlet 42, second ultrafiltration is carried out, to improve the recovery rate of medicament after mixing with the dilute liquid medicine in tank.。
In specific works, be stored in dilute liquid medicine holding vessel 1 after first medicine liquid heating being diluted, through booster pump 2, dilute liquid medicine is pumped into cartridge filter 3, the filtered solution of dilute liquid medicine after cartridge filter 3 filters enters ultrafiltration apparatus 4, filtered solution forms the first purification liquid and coarse filtration liquid after the filtration of ultrafiltration apparatus 4, and wherein coarse filtration liquid returns in dilute liquid medicine holding vessel 1 and carries out second ultrafiltration.First purification liquid is stored in transfer tank 5, and the first purification liquid pump in transfer tank 5 is delivered in reverse osmosis unit 7 by high-pressure pump 6, and according to the difference to final liquor strength demand, reverse osmosis unit 7 can be first-stage reverse osmosis or two-pass reverse osmosis.If one-level, only need a high-pressure pump 6, after reverse osmosis unit 7 has filtered, clean liquid discharge, concentrated liquid is stored in storage tank 8.If two-pass reverse osmosis, then need two high-pressure pumps, 6, two high-pressure pumps 6 be liquid repeatedly through reverse osmosis unit 7, finally obtain the concentrated medicament of high concentration.
More than show and describe general principle of the present invention, principal character and advantage of the present invention.The technical staff of the industry should understand; the present invention is not restricted to the described embodiments; the just principle of the present invention described in above-described embodiment and description; the present invention also has various changes and modifications without departing from the spirit and scope of the present invention, and these changes and improvements all fall in claimed scope of the present invention.The protection domain of application claims is defined by appending claims and equivalent thereof.
Claims (9)
1., for an equipment for Chinese traditional medicine purification, it is characterized in that: described equipment comprise be communicated with by the road successively have dilute liquid medicine holding vessel, booster pump, cartridge filter, ultrafiltration apparatus, transfer tank, high-pressure pump, reverse osmosis unit, storage tank; Described ultrafiltration apparatus comprises putamina and milipore filter; Described milipore filter is in putamina; The aperture of described milipore filter is 0.1 μm ~ 0.001 μm; Described ultrafiltration apparatus has the first outlet and the second outlet; Described first outlet is communicated with described transfer tank; Described second outlet is connected with the import of described dilute liquid medicine holding vessel.
2. a kind of equipment for Chinese traditional medicine purification according to claim 1, is characterized in that: the aperture of described milipore filter is 0.001 μm.
3. a kind of equipment for Chinese traditional medicine purification according to claim 1, is characterized in that: described cartridge filter comprises security personnel's filter membrane; The aperture of described security personnel's filter membrane is 0.22 μm.
4. a kind of equipment for Chinese traditional medicine purification according to claim 1, is characterized in that: described reverse osmosis unit comprises reverse osmosis membrane; The aperture of described reverse osmosis membrane is 0.0001 μm.
5. a kind of equipment for Chinese traditional medicine purification according to claim 1, is characterized in that: described reverse osmosis unit is first-stage reverse osmosis device or second level reverse osmosis apparatus.
6. a kind of equipment for Chinese traditional medicine purification that applying described claim 5 provides carries out the method for Chinese traditional medicine purification, it is characterized in that: comprise the following steps:
A. liquid dilution: add water heating dilute liquid medicine;
B. cool: to the liquid cooling after heating dilution;
C. essence filter: adopt cartridge filter tentatively to filter liquid;
D. ultrafiltration: the liquid filtered through cartridge filter in step c forms first order purification liquid and coarse filtration liquid after ultrafiltration apparatus filters;
E. osmosis filtration: the first order purification liquid in steps d enters reverse osmosis unit by described first outlet.
7. the method for Chinese traditional medicine purification according to claim 6, is characterized in that: in described step a, the temperature of dilute liquid medicine is 80 DEG C.
8. the method for Chinese traditional medicine purification according to claim 6, is characterized in that: in described step b, liquid is cooled to 40 DEG C.
9. the method for Chinese traditional medicine purification according to claim 6, is characterized in that: the coarse filtration liquid described in described steps d returns described dilute liquid medicine storage tank by described second outlet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510808847.7A CN105289308A (en) | 2015-11-19 | 2015-11-19 | Equipment for traditional Chinese medicine purification and applications thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510808847.7A CN105289308A (en) | 2015-11-19 | 2015-11-19 | Equipment for traditional Chinese medicine purification and applications thereof |
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| Publication Number | Publication Date |
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| CN105289308A true CN105289308A (en) | 2016-02-03 |
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| CN201510808847.7A Pending CN105289308A (en) | 2015-11-19 | 2015-11-19 | Equipment for traditional Chinese medicine purification and applications thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113694795A (en) * | 2021-09-27 | 2021-11-26 | 成都倍特药业股份有限公司 | Liquid preparation system and preparation method |
Citations (5)
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|---|---|---|---|---|
| CN201729784U (en) * | 2010-07-22 | 2011-02-02 | 甘肃省膜科学技术研究院 | Membrane separation device for concentrating thymosin solution |
| CN102816251A (en) * | 2012-06-18 | 2012-12-12 | 北京生泰尔生物科技有限公司 | High-activity astragalus polysaccharide and preparation method of pharmaceutical composition of high-activity astragalus polysaccharide |
| CN103655649A (en) * | 2013-12-10 | 2014-03-26 | 广东万年青制药有限公司 | Production technology for concentrating raw material extract of traditional Chinese medicine preparation of anti-inflammation and cholagogic tablet |
| CN203763988U (en) * | 2014-03-04 | 2014-08-13 | 福州东星生物技术有限公司 | Multi-stage membrane filtration and concentration device |
| CN205145993U (en) * | 2015-11-19 | 2016-04-13 | 安徽元通水处理设备有限公司 | A equipment for traditional chinese medicine purification |
-
2015
- 2015-11-19 CN CN201510808847.7A patent/CN105289308A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201729784U (en) * | 2010-07-22 | 2011-02-02 | 甘肃省膜科学技术研究院 | Membrane separation device for concentrating thymosin solution |
| CN102816251A (en) * | 2012-06-18 | 2012-12-12 | 北京生泰尔生物科技有限公司 | High-activity astragalus polysaccharide and preparation method of pharmaceutical composition of high-activity astragalus polysaccharide |
| CN103655649A (en) * | 2013-12-10 | 2014-03-26 | 广东万年青制药有限公司 | Production technology for concentrating raw material extract of traditional Chinese medicine preparation of anti-inflammation and cholagogic tablet |
| CN203763988U (en) * | 2014-03-04 | 2014-08-13 | 福州东星生物技术有限公司 | Multi-stage membrane filtration and concentration device |
| CN205145993U (en) * | 2015-11-19 | 2016-04-13 | 安徽元通水处理设备有限公司 | A equipment for traditional chinese medicine purification |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113694795A (en) * | 2021-09-27 | 2021-11-26 | 成都倍特药业股份有限公司 | Liquid preparation system and preparation method |
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Application publication date: 20160203 |
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