CN105268109A - System for regulating and controlling tumor tissue metabolism - Google Patents
System for regulating and controlling tumor tissue metabolism Download PDFInfo
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- CN105268109A CN105268109A CN201410231898.3A CN201410231898A CN105268109A CN 105268109 A CN105268109 A CN 105268109A CN 201410231898 A CN201410231898 A CN 201410231898A CN 105268109 A CN105268109 A CN 105268109A
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- light source
- fnirs
- tumor
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Abstract
The invention discloses a system for regulating and controlling tumor tissue metabolism. The system comprises a computer central controller, a laser light source, a temperature measuring instrument, an FNIRS light source, an FNIRS spectrometer, an EPR free radical detector and an electric acupuncture apparatus, wherein the laser light source, the temperature measuring instrument, the FNIRS light source, the FNIRS spectrometer, the EPR free radical detector and the electric acupuncture apparatus are connected with the computer central controller, and the computer central controller controls electric acupuncture output frequency of the electric acupuncture apparatus acted on a tumor tissue according to a detected temperature, an optimized scattering coefficient, the blood oxygen content, the oxygen partial pressure, a pH value and the free radical content of the tumor tissue. Through regulating and controlling the tumor tissue metabolism, the system disclosed by the invention enables the structure of the tumor tissue to be changed and finally induces the tumor to give up evil and return to good, and prevents normal tissue cells from being damaged while effectively treating the tumor.
Description
Technical field
The present invention relates to a kind of medical apparatus system, the anabolic system of especially a kind of modulate tumor.
Background technology
Tumor (Tumor) be body under various carcinogenic factor effect, some cells of local organization lose the normal regulation to its growth on gene level, cause its clonal abnormality hypertrophy and the abnormality that formed.
The organizational structure of tumor is varied, but the component of organization of all tumors all can be divided into essence and interstitial two parts.
(1) essence of tumor: tumor epithelial cell is the general name of tumor cell is the main component of tumor.It determines the Biological characteristics of tumor and the particularity of often kind of tumor.Usually identify the tissue-derived of various tumor according to the essence form of tumor, carry out the classification of tumor, name and histodiagnosis, and determine the grade malignancy of the good pernicious of tumor and tumor according to its differentiation and maturation degree and atypia size.
(2) interstitial of tumor: the interstitial components of tumor does not have a specificity, plays a part to support and nutrition tumor epithelial cell.Generally be made up of connective tissue and blood vessel, interstitial also has lymphatic vessel sometimes.Usual growth fraction tumor faster, its interstitial blood vessel is generally comparatively abundant and connective tissue is less; Poky tumor, its interstitial blood vessel is usually less.In addition, tumor often has the monocyte infiltrations such as lymphocyte, and this is the immunoreation of body to tumor tissues.In addition, fibroblast and myofibroblast can also be seen in tumor connective tissue.Flesh dimension blast cell has the dual characteristics of fibroblast and smooth muscle cell, this cell can produce collagen fiber, again there is contractile function, may limit to some extent the infiltration of tumor cell, the hypertrophy of this cell can explain the nipple retraction of breast carcinoma, and the intestinal tube that the esophageal carcinoma and intestinal cancer cause is stiff and narrow.
The atypia of the organizational structure of tumor refer to tumor tissues in spatial arrangements mode (comprise pole to, organ spline structure and with the relation of interstitial etc. in) with the difference of the normal structure in its source.The atypia of benign tumor oncocyte is not obvious, but arrangement is different from normal structure, and diagnosis depends on the atypia of organizational structure, as leiomyoma of uterus.The organizational structure atypia of malignant tumor is obvious, and oncocyte arrangement is more disorderly, lose normal arrangement architecture, level or pole to, as fibrosarcoma, adenocarcinoma.
The characteristic of our Chinese medical is that existing doctor trained in Western medicine has the traditional Chinese medical science again.Present sickness rate is high, and China's case load is quite huge, has data to show and accounts for 55%. of whole world case load
Tumor is genopathy in itself.Various environment cause DNA to damage with the carcinogenic factor of heredity with collaborative or sequential mode, thus activate proto-oncogene and (or) deactivation tumor suppressor gene, add the change of apoptosis gene and (or) DNA-repair gene, then cause the exception of expression, target cell is transformed.The cell be converted is first many in Clonal hypertrophy, through a very long multistage evolution process, one of them clones relatively unconfined amplification, pass through addition mutation, optionally form the sub-clone (heterogeneousization) with different characteristics, thus obtain the ability (vicious transformation) of invasion and m etastasis, form malignant tumor.
At present, treatment tumor instrument, mainly by LASER HEATING tumor tissues, makes it to reach more than 45 degrees Celsius, and then kills cancerous cell.This instrument, limited by the therapeutical effect of the mode killing or remove tumor tissues simply, but also can damaging normal tissue cells.
Summary of the invention
The object of this invention is to provide a kind of by modulate tumor tissue metabolism so that the structure of tumor tissues is changed, the anabolic system of modulate tumor that final induced tumor is turned over a new leaf, effectively prevent normal tissue cell from sustaining damage while treatment tumor.
In order to achieve the above object, following technical scheme is adopted:
The anabolic system of a kind of modulate tumor, this system comprises computer central controller, and the LASER Light Source, temperature measurer, FNIRS light source, FNIRS spectrogrph, EPR free radical detector and the electric acupuncture apparatus that are connected with described computer central controller; Described computer central controller controls LASER Light Source sends laser to tumor tissues, and detects the temperature of tumor tissues by the temperature sensing probe of temperature measurer front end; Described computer central controller controls FNIRS light source sends near infrared light, and detects optimization scattering coefficient and the oxygen content of tumor tissues by the detection probe of FNIRS spectrogrph front end; Described computer central controller controls EPR free radical detector detects the partial pressure of oxygen of tumor tissues, pH value and free-radical contents; Described computer central controller according to the temperature of the tumor tissues detected, optimize scattering coefficient, oxygen content, partial pressure of oxygen, pH value and free-radical contents control action in the acusector output frequency of the electric acupuncture apparatus of tumor tissues, its output frequency formula is as follows:
f＝(1000μ’
s*T+SPO
2H*PO
2)*PH*FR；
Wherein, f-output frequency, μ '
s-optimize scattering coefficient, T-temperature, pH-pH value, FR-free-radical contents, PO
2-partial pressure of oxygen, SPO
2h-oxygen content.
Further, the wavelength that described LASER Light Source sends is 1310 nanometers, 1319 nanometers or 1941 nanometers.
Further, when the temperature that described temperature measurer detects reaches 43.5 degrees Celsius, computer control system controls LASER Light Source and quits work until restart described LASER Light Source again after 38.6 degrees Celsius.
Further, the output selection load impedance of described electric acupuncture apparatus is the filiform needle electrode of 250 ohm.
Further, what described FNIRS light source exported is wavelength near infrared light between 780 nanometer to 830 nanometers.
Further, the EPR probe sets of the temperature sensing optical fiber of the laser fiber of described LASER Light Source, temperature measurer, the FNIRS optical fiber of FNIRS light source, the FNIRS sensor fibre of FNIRS spectrogrph and EPR free radical detector is combined in same five holes probe.
Further, described computer central controller is also connected with the I/O device that display for showing various figure and data and handled easily control.
Computer central controller of the present invention according to the temperature of the tumor tissues detected, optimize scattering coefficient, oxygen content, partial pressure of oxygen, pH value and free-radical contents control action in the acusector output frequency of the electric acupuncture apparatus of tumor tissues, the acusector constantly changed by the frequency calculated acts on tumor tissues, and then change tumor cell and the energy metabolism of environment residing for it, and then the structure of tumor tissues is changed, final induced tumor is turned over a new leaf.Therefore, present system when not damaging normal tissue, fundamentally effectively can treat tumor.
Accompanying drawing explanation
Fig. 1 is hardware configuration schematic diagram of the present invention;
Fig. 2 is five holes probe sectional view of the present invention;
Fig. 3 is the workflow diagram of computer central controller of the present invention.
Diagram:
101-computer central controller; 102-LASER Light Source;
103-temperature measurer; 104-FNIRS light source;
105-FNIRS spectrogrph; 106-EPR free radical detector;
107-electric acupuncture apparatus; 108-I/O device;
109-display;
200-five holes probe;
1021-laser fiber; 1031-temperature sensing optical fiber
1041-FNIRS optical fiber; 1051-FNIRS sensor fibre
1061-EPR probe, 1071-acusector
Detailed description of the invention
Describe the present invention in detail below in conjunction with accompanying drawing and specific implementation method, be used for explaining the present invention in exemplary embodiment and description of the present invention, but not as a limitation of the invention.
Embodiment one
As shown in Figure 1, present embodiment discloses the anabolic system of a kind of modulate tumor, this system comprises computer central controller 101, and the LASER Light Source 102, temperature measurer 103, FNIRS light source 104, FNIRS spectrogrph 105, EPR free radical detector 106, electric acupuncture apparatus 107, I/O device 108 and the display 109 that are connected with described computer central controller 101.
As shown in Figure 3, the work process of native system and principle as follows:
S10, computer central controller 101 control LASER Light Source 102 and send laser to tumor tissues, and detect the temperature of tumor tissues by the temperature sensing probe of temperature measurer 103 front end, the wavelength that described LASER Light Source sends is 1310 nanometers, 1319 nanometers or 1941 nanometers, the laser of these three wave bands certain has biological tissue and absorbs strong characteristic, carrying out irradiating biological tissue with them is, there is stronger absorbability and then heating tumor cell, then pass through temperature measurer 103 to detect the real time temperature of tumor tissues, native system does not directly kill tumor system but crosses the metabolism of regulation and control tumor tissues, and then the structure of tumor tissues is changed, final induced tumor is turned over a new leaf, so when the temperature that described temperature measurer detects reaches 43.5 degrees Celsius, computer control system controls LASER Light Source and quits work until restart described LASER Light Source again after 38.6 degrees Celsius, thus make the temperature acting on tumor tissues control between 38.6 degrees Celsius to 43.5 degrees Celsius, the gene information that not only can be conducive to induced tumor Interstitial cell is expressed, can also assist to change tumor cell and the energy metabolism of environment residing for it,
S20, computer central controller controls FNIRS light source send near infrared light, and optimization scattering coefficient and the oxygen content of tumor tissues is detected by the detection probe of FNIRS spectrogrph front end, what described FNIRS light source exported is wavelength near infrared light between 780 nanometer to 830 nanometers; Near-infrared (nearinfrared), wavelength is at the electromagnetic wave of 780 ~ 3000nm scope, but the present invention only selects wavelength near infrared light between 780 nanometer to 830 nanometers, after the near infrared light of this wave band enters tumor tissues, can be absorbed by tissue better and scattering, moreover, FNIRS spectrogrph can also be coordinated better to check the feature of tumor tissues inside: optimize scattering coefficient and oxygen content, the optimization scattering coefficient measurement error in this wavelength stage, within 0.5%, optimizes scattering coefficient μ '
sunit is cm
-1, with the relation of wavelength X be:
μ '
s=-0.02065R λ+88.55R-0.00171 λ+3.1159, R is reflection coefficient; People is by oxygen existence, and oxygen sucks rear oxygen from pulmonary and just enters into blood through blood capillary, sends parts of body organ or cell use to by blood.In blood, oxygen content is higher, and the metabolism of people is better, and the present invention wants modulate tumor tissue metabolism, naturally can't do without the content will monitoring needs;
S30, computer central controller controls EPR free radical detector detect the partial pressure of oxygen of tumor tissues, pH value and free-radical contents; EPR, be the abbreviation of electron paramagnetic resonance (electronparamagneticresonance), that is to say that EPR free radical detector of the present invention is exactly the partial pressure of oxygen utilizing electron paramagnetic resonance principle to detect tumor tissues, pH value and a free-radical contents; Partial pressure of oxygen (PO
2) refer to the tension force (therefore also known as oxygen tension) that the oxygen molecule be dissolved in blood plasma with physical state produces.PO
2depend primarily on alveolar pO2 (PAO
2) height, oxygen entered the ratio of the amount of blood, alveolar ventilation and pulmonary blood flow volume by alveolar membrane disperse.If outside air partial pressure of oxygen is low or alveolar ventilation reduces, alveolar pO2 is reduced, or diffusion disorder, ventilation/blood flow are out of proportion, make the functional or anatomical shunting increase of lung artery-vein blood, all can make PaO
2reduce; Free radical (freeradical), chemically also referred to as " free radical ", is the atomic group containing a unpaired electron.Chemical property is very active, is easy to lose electronics (oxidation) or obtain electronics (reduction), particularly its Oxidation by force, therefore has the effect of strong initiation lipid peroxidation; Controlled radical pair human body is useful.But when free radical in human body exceedes certain amount, and time out of hand, this free radical bring injury will to our life, the present invention also will monitor this important parameter naturally in order to modulate tumor cell tissue; Moreover, in order to reach the effect of better regulation and control and guiding tumor tissues, invention also have detected the pH value of tumor tissues simultaneously;
S40, computer central controller according to the temperature of the tumor tissues detected, optimize scattering coefficient, oxygen content, partial pressure of oxygen, pH value and free-radical contents control action in the acusector output frequency of the electric acupuncture apparatus of tumor tissues, its output frequency formula is as follows:
f＝(1000μ’
s*T+SPO
2H*PO
2)*PH*FR；
Wherein, f-output frequency, μ '
s-optimize scattering coefficient, T-temperature, pH-pH value, FR-free-radical contents, PO
2-partial pressure of oxygen, SPO
2h-oxygen content.
Such as, temperature T is 40 DEG C, optimizes scattering coefficient μ '
sfor 50cm
-1, oxygen content SPO
2h is 90, partial pressure of oxygen PO
2for 13.3kPa, pH value is 7, and free-radical contents FR is 1.2 μm of ol/g, then draw output frequency according to above-mentioned formulae discovery:
Output frequency f=(1000*50*40+90*13.3K) * 7*1.2 μ=26.8548 hertz.
Because the factor affecting acusector output frequency f is all constantly change in mechanism, so acusector output frequency f frequency also can change thereupon, the laserthermia of (38.6 DEG C to 43.5 DEG C) under the Electroacupuncture plus specified temp of continuous change, and the combined effect of near infrared light, thus the gene information of induced tumor Interstitial cell is expressed, change tumor cell and the energy metabolism of environment residing for it, and then the structure of tumor tissues is changed, final induced tumor is turned over a new leaf, and plays the object for the treatment of.
As shown in Figure 2, in order to act on tumor tissues and monitoring parameters simultaneously, the EPR probe 1061 of the laser fiber 1021 of described LASER Light Source, the temperature sensing optical fiber 1031 of temperature measurer, the FNIRS optical fiber 1041 of FNIRS light source, the FNIRS sensor fibre 1051 of FNIRS spectrogrph and EPR free radical detector is integrated in same five holes probe 200.
In order to play the regulating and controlling effect better played tumor tissues, the output selection load impedance of described electric acupuncture apparatus is the filiform needle electrode of 250 ohm.
Conveniently user operation, described computer central controller 101 is also connected with the I/O device 108 that display 109 for showing various figure and data and handled easily control, and shown I/O device comprises keyboard, mouse or touch screen etc.
Above the technical scheme that the embodiment of the present invention provides is described in detail, apply specific case herein to set forth the principle of the embodiment of the present invention and embodiment, the explanation of above embodiment is only applicable to the principle helping to understand the embodiment of the present invention; Meanwhile, for one of ordinary skill in the art, according to the embodiment of the present invention, detailed description of the invention and range of application all will change, and in sum, this description should not be construed as limitation of the present invention.
Claims (7)
1. the anabolic system of modulate tumor, it is characterized in that, this system comprises computer central controller, and the LASER Light Source, temperature measurer, FNIRS light source, FNIRS spectrogrph, EPR free radical detector and the electric acupuncture apparatus that are connected with described computer central controller; Described computer central controller controls LASER Light Source sends laser to tumor tissues, and detects the temperature of tumor tissues by the temperature sensing probe of temperature measurer front end; Described computer central controller controls FNIRS light source sends near infrared light, and detects optimization scattering coefficient and the oxygen content of tumor tissues by the detection probe of FNIRS spectrogrph front end; Described computer central controller controls EPR free radical detector detects the partial pressure of oxygen of tumor tissues, pH value and free-radical contents; Described computer central controller according to the temperature of the tumor tissues detected, optimize scattering coefficient, oxygen content, partial pressure of oxygen, pH value and free-radical contents control action in the acusector output frequency of the electric acupuncture apparatus of tumor tissues, its output frequency formula is as follows:
f＝(1000μ’
s*T+SPO
2H*PO
2)*PH*FR；
Wherein, f-output frequency, μ '
s-optimize scattering coefficient, T-temperature, pH-pH value, FR-free-radical contents, PO
2-partial pressure of oxygen, SPO
2h-oxygen content.
2. the anabolic system of modulate tumor according to claim 1, is characterized in that:
The wavelength that described LASER Light Source sends is 1310 nanometers, 1319 nanometers or 1941 nanometers.
3. the anabolic system of modulate tumor according to claim 1, is characterized in that:
When the temperature that described temperature measurer detects reaches 43.5 degrees Celsius, computer control system controls LASER Light Source and quits work until restart described LASER Light Source again after 38.6 degrees Celsius.
4. the anabolic system of modulate tumor according to claim 1, is characterized in that:
The output selection load impedance of described electric acupuncture apparatus is the filiform needle electrode of 250 ohm.
5. the anabolic system of modulate tumor according to claim 1, is characterized in that:
What described FNIRS light source exported is wavelength near infrared light between 780 nanometer to 830 nanometers.
6. the anabolic system of modulate tumor according to claim 1, is characterized in that:
The EPR probe sets of the FNIRS optical fiber of the laser fiber of described LASER Light Source, the temperature sensing optical fiber of temperature measurer, FNIRS light source, the FNIRS sensor fibre of FNIRS spectrogrph and EPR free radical detector is combined in same five holes probe.
7. the anabolic system of modulate tumor according to claim 1, is characterized in that:
Described computer central controller is also connected with the I/O device that display for showing various figure and data and handled easily control.
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|---|---|---|---|
| CN201410231898.3A CN105268109B (en) | 2014-05-28 | 2014-05-28 | A kind of system of modulate tumor tissue metabolism |
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| CN201410231898.3A CN105268109B (en) | 2014-05-28 | 2014-05-28 | A kind of system of modulate tumor tissue metabolism |
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| CN105268109B CN105268109B (en) | 2018-01-16 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106039593A (en) * | 2016-06-24 | 2016-10-26 | 南京宽诚科技有限公司 | Laser irradiation system based on tissue blood oxygen detection |
| CN107998515A (en) * | 2018-01-19 | 2018-05-08 | 深圳恩鹏健康产业股份有限公司 | A kind of intelligence metabolic balance instrument and system |
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| US4930504A (en) * | 1987-11-13 | 1990-06-05 | Diamantopoulos Costas A | Device for biostimulation of tissue and method for treatment of tissue |
| WO2001021256A1 (en) * | 1999-09-20 | 2001-03-29 | Susanne Johansson | Laser probe for medical treatment |
| CN101391133A (en) * | 2008-10-15 | 2009-03-25 | 上海奥通激光技术有限公司 | Dual wavelength laser therapeutic method and equipment |
| CN101411921A (en) * | 2007-10-17 | 2009-04-22 | 徐瑛 | Laser magnetoelectric integrated therapeutic technique and multifunctional therapeutical instrument |
-
2014
- 2014-05-28 CN CN201410231898.3A patent/CN105268109B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4930504A (en) * | 1987-11-13 | 1990-06-05 | Diamantopoulos Costas A | Device for biostimulation of tissue and method for treatment of tissue |
| WO2001021256A1 (en) * | 1999-09-20 | 2001-03-29 | Susanne Johansson | Laser probe for medical treatment |
| CN101411921A (en) * | 2007-10-17 | 2009-04-22 | 徐瑛 | Laser magnetoelectric integrated therapeutic technique and multifunctional therapeutical instrument |
| CN101391133A (en) * | 2008-10-15 | 2009-03-25 | 上海奥通激光技术有限公司 | Dual wavelength laser therapeutic method and equipment |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106039593A (en) * | 2016-06-24 | 2016-10-26 | 南京宽诚科技有限公司 | Laser irradiation system based on tissue blood oxygen detection |
| CN106039593B (en) * | 2016-06-24 | 2018-05-15 | 南京宽诚科技有限公司 | LASER Illuminator System based on tissue oxygenation detection |
| CN107998515A (en) * | 2018-01-19 | 2018-05-08 | 深圳恩鹏健康产业股份有限公司 | A kind of intelligence metabolic balance instrument and system |
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| CN105268109B (en) | 2018-01-16 |
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