CN105267273A - Natural skin-protecting wound disinfectant and preparation method thereof - Google Patents
Natural skin-protecting wound disinfectant and preparation method thereof Download PDFInfo
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- CN105267273A CN105267273A CN201510882102.5A CN201510882102A CN105267273A CN 105267273 A CN105267273 A CN 105267273A CN 201510882102 A CN201510882102 A CN 201510882102A CN 105267273 A CN105267273 A CN 105267273A
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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Abstract
The invention relates to a skin-protecting wound disinfectant. The skin-protecting wound disinfectant is prepared from 1%-5% of chitosan oligosaccharide, 30%-40% of medical ethanol, 5%-20% of sweet wormwood herb extracting solution, 5%-30% of moringa leaf extracting solution, 0.5%-5% of moringa seed oil and the balance deionized water. According to the skin-protecting wound disinfectant, the chitosan oligosaccharide is dissolved in the moringa leaf extracting solution and the sweet wormwood herb extracting solution and resists bacteria by cooperating with sweet wormwood herbs, moringa seeds and low-concentration ethanol, the chitosan oligosaccharide does not settle in the low-concentration ethanol, and the antibacterial effectiveness of the disinfectant is guaranteed. Significant sterilization and disinfection effects on pathogenic bacteria such as common staphylococcus, streptococcus and escherichia coli, common cold viruses and the like are achieved without adding antibiotics or other chemosynthetic antibiotic constituents, and moringa leaves and moringa seeds both have significant skin-protecting and moisturizing effects. Therefore, by means of the skin-protecting wound disinfectant, a moistening use feeling is achieved, a protection effect on skins is achieved, the antibacterial and skin-protecting effects are lastingly effective, toxic and side effects to human bodies do not exist, and pollution to the environment does not exist.
Description
Technical field
The invention belongs to medical health product field, particularly a kind of natural skin care Wound disinfectant and preparation method thereof.
Background technology
Disinfectant solution can greatly reduce chance and the quantity that pathogenic bacteria enters human body, is the requisite product of medical health field.The feature such as desirable disinfectant liquid for skin should possess nontoxic, noresidue, corrosion-free, non-stimulated, safe and cheap and easy to get to humans and animals, environmental pollution degree is low.Disinfectant liquid for skin common on market has ethanol formulation, Iodic agent, chlorhexidine, triclosan, quaternary ammonium salt etc., these disinfection compositions are all chemical products, while disinfection, have certain stimulation to skin, common skin be dry, be chapped from the cold, skin resistance declines, epidermal cornified etc.Although product experience can be improved by adding skin care ingredient, during life-time service, still there is strong negative effect to Skin Cell.Therefore not only there is antibiotic and sterilizing function but also can the disinfectant liquid for skin of skin protection be relevant enterprise study hotspot always.
Ethanol is the most frequently used disinfectant solution composition; concentration of alcohol is very relevant to its model of action; the general concentration of ethanol disinfection liquid is all 75%; excessive concentration can form protecting film at surface layers of bacteria; stop ethanol to enter in bacterial body and kill antibacterial, when concentration is too low, although ethanol can enter in bacterial body; but can not by protein coagulation in bacterial body, therefore bactericidal effect is undesirable.Although 75% is optimal concentration, but this concentration has a lot of negative effect to Skin Cell, such as cause Skin Cell to follow the string, become drying, immunity reduction, keratinization etc., therefore, with ethanol as the disinfectant liquid for skin composition of life-time service, just need scientifically other compositions of compatibility.
In recent years, the antibacterial functions of chitosan slowly became study hotspot, and generally believe that Chitosan-phospholipid complex has good anti-microbial property, therefore Chitosan-phospholipid complex is widely used in the fields such as healthcare products, cosmetics, food.Chinese patent 201410700209.9 discloses a kind of Chinese herbal medicine skin mucosa disinfectant, is exactly to adopt chitosan quaternary ammonium salt as sterilization component, plays antibiotic effect with zephiran together with herbal component.Chitosan is also known as chitin, and be extensively present in the cell wall of the shell of Crustacean, the carapace of insecticide and fungus, being also present in some chlorellas, is a kind of natural macromolecule amylose body, by deacetylated, can obtain the chitosan of different molecular weight.By chitosan through degradation technique process, can obtain the oligosaccharide product of the degree of polymerization between 2-20, also known as oligochitosan, molecular weight is generally lower than 3000.
Oligochitosan can be water-soluble, and also have stronger antibacterial efficacy, but commercially available price is higher, and oligochitosan sedimentation can occur in ethanol, this is also a kind of mode chemical industry reclaiming oligochitosan; Therefore, when using oligochitosan as disinfectant solution component, scientifically need consider disinfectant solution compatibility composition, should disinfection efficacy be ensured, balance preparation cost again.
Disinfectant solution for wound is different with the common disinfectant solution for skin, wound is due to open and exposure, disinfectant solution is needed to have stronger bactericidal action, conventional medical ethanol concentration is 75%, although bactericidal effect is remarkable, there is comparatively strong stimulation to wound, if wound is in the obvious and place that skin is thinner such as face, stay cicatrix to affect after skin also can be caused to recover attractive in appearance, but but the lower medical ethanol of concentration does not have enough strong fungicidal effectiveness.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art, a kind of disinfectant liquid for skin of complete pure natural components is provided.
Technical scheme of the present invention is as follows:
A kind of natural skin care Wound disinfectant, its component and weight content as follows:
Wherein said oligochitosan molecular weight is less than 3000.
Wherein said Herba Artemisiae Annuae extracting solution be dry artemisia leaf by decocting cooking method concentration extraction, every milliliter of Herba Artemisiae Annuae is carried
Getting liquid containing crude drug amount is 0.5-2g.
Wherein said leaf of Moringa extracting solution is that dry leaf of Moringa is extracted by the way of distillation.
Wherein said seed oil of Moringa oleigera is that Moringa seed is prepared by aqueous enzymatic method and obtains.
Preferably, described oligochitosan addition is 3%.
Preferably, described Herba Artemisiae Annuae extracting solution addition is 15%.
Preferably, described leaf of Moringa extracting solution addition is 30%.
Preferably, described seed oil of Moringa oleigera addition is 1%.
The present invention provides a kind of preparation method of natural skin care Wound disinfectant simultaneously, its step is, by the above Herba Artemisiae Annuae extracting solution and leaf of Moringa extracting solution mixing and stirring, add chitosan, dissolve in dissolution kettle, solution temperature is 25 DEG C-30 DEG C, dissolve completely, add the medical ethanol of 75%, after stirring, add seed oil of Moringa oleigera and deionized water, stir and get final product.
Attestedly be, along with chitosan molecule amount reduces, antibacterial activity can improve, therefore, select oligochitosan as the composition of Wound disinfectant, the antibiotic effect of energy strengthen disinfection liquid, in order to ensure the antibiotic effect of Wound disinfectant further, point ethanol had better be used, but it is well known that oligochitosan in ethanol can sedimentation, in the technical program, oligochitosan is dissolved in leaf of Moringa extracting solution and Herba Artemisiae Annuae extracting solution, owing to containing very abundant micromolecule organic principle in leaf of Moringa extracting solution and Herba Artemisiae Annuae extracting solution, the molecular structure after oligochitosan dissolving can be stablized, when the concentration finally adding 30-40% is the medical ethanol of 75%, not there is sedimentation in oligochitosan.
Herba Artemisiae Annuae is the very common wild plant in Yunnan, although now famous arteannuin at present can only from of a Herba Artemisiae Annuae kind---extract Herba Artemisiae annuae and obtain, this is because Artemisinin from Artemisia Annua L content is more than 5%, be worth extracting, but in fact also containing a certain amount of arteannuin in the Herba Artemisiae Annuae of other kinds, and more than arteannuin, other compositions in Herba Artemisiae Annuae have the scope of application widely.Put on the skin outside medicinal liquid after all having adopted Herba Artemisiae Annuae decocting in water since the tradition of Yunnan and can treat dermatosis, the effect with antipyretic antiinflammatory for oral administration.Containing very abundant organic principle in Herba Artemisiae Annuae decocting liquid, to staphylococcus, micrococcus catarrhalis, anthrax bacillus, diphtheria corynebacterium, bacillus pyocyaneus, dysentery bacterium, tubercule bacillus, dysentery bacterium, escherichia coli, micrococcus catarrhalis, A type and Bacillus paratyphosus B all have certain antibacterial action.Sitosterol in Herba Artemisiae Annuae and stigmasterol also have antivirus action.
Moringa is the tree of the one mystery that China introduces from India, only has plantation on the ground such as Yunnan, Guangdong at present, and wherein with the growth of area, Yuanjiang County of Yunnan hot river valley is best.Leaf of Moringa nutritional labeling is very abundant, has a large amount of investigation and application in food.In the leaf of Moringa extracting solution adopting the way of distillation to obtain, organic containing abundant micromolecule, healthy skin is had to cell activity enhancing, improves the effect of resistance, impaired skin is had to the effect of absorbing toxin, Promotive union.
The seed oil of Moringa oleigera that moringa seeds obtains through aqueous enzymatic method not only comprises common oils and fats, also containing a large amount of derived essential oil, not only there is effect of lock water moisturizing, also there is the effect of anti-inflammation, and seed oil of Moringa oleigera has unique infiltration import feature, skin bottom cell can be arrived fast, other components in disinfectant solution be had to the effect strengthening effect.Moringa seeds as medicine, is had the effects such as sterilization, hepatoprotective, adjustment the intestines and stomach, skin moistening by Ayurvedic medicine.The present invention uses a small amount of seed oil of Moringa oleigera as skin moistening moisturizing component, is also the component guiding sterilization component to infiltrate skin fast simultaneously, but can not be multiplex, because moringa seeds has water purification effect, multiplex meeting causes flocculation reaction.
Beneficial effect of the present invention is as follows:
1. disinfection effect is remarkable: the oligochitosan that the present invention uses, Herba Artemisiae Annuae, moringa seeds all have natural antibacterial ingredient, after combination, there is synergism, the antimicrobial component of antibiotic or other chemosynthesis need not be added, can all have significant disinfection effect to pathogenic bacterium and cold virus etc. such as common staphylococcus, streptococcus, escherichia coli.Oligochitosan can with Herba Artemisiae Annuae extracting solution synergism, the two jointly obtains stronger antibacterial efficacy.Due to the antibacterial action of these compositions, therefore this product adds the medical ethanol of 30-40% again, ethanol has superpower penetration, antimicrobial component can be led to enter in bacterial body play a role, therefore wound disinfection effect can be ensured, and in technical scheme of the present invention not there is sedimentation in oligochitosan, may be used for suitability for industrialized production completely; Meanwhile, because oligochitosan has good film property, be coated on skin and can form membranaceous material together, skin wound is protected.
2. natural component, skin protection moisturizing: oligochitosan of the present invention, Herba Artemisiae Annuae, leaf of Moringa, moringa seeds are all natural components, raw material sources are extensive, particularly Moringa, and leaf of Moringa and moringa seeds have unique lock water constituent, have good moisturizing effect to skin.Moringa is used as high-end health nutrient after introducing China always, but due to conducting vigorous propaganda in recent years, the ground such as Yunnan are planted in a large number, drop in the market price one road, quantity and price can meet the demand of other industry suitability for industrialized production completely, therefore can realize the more practical function of Moringa.
3. experience comfortable: composition of the present invention is all natural materials; without any the sensation of discomfort on healthy skin; on impaired skin, slightly there is a sensation of pricking, but after medicinal liquid is air-dry, on skin, leaves the membranaceous material of one deck, to impaired skin, there is protective effect.
4. safe and effective: preparation method of the present invention is simple, antibiotic skin-care effect is effective lastingly, to human non-toxic's side effect, to zero environmental.
Detailed description of the invention
Further illustrate technical scheme of the present invention below by way of specific embodiment, but technical scheme of the present invention is not limited with embodiment.
Embodiment 1:
A preparation method for natural skin care Wound disinfectant, comprises the steps:
(1) dry artemisia leaf is obtained Herba Artemisiae Annuae extracting solution by decocting cooking method is concentrated, every milliliter of Herba Artemisiae Annuae extracting solution is 0.5-2g containing crude drug amount.
(2) dry leaf of Moringa is obtained leaf of Moringa extracting solution by way of distillation extraction, only adopt the still head distillate of 15 minutes.
(3) by percentage by weight be the leaf of Moringa extracting solution of 20% and the Herba Artemisiae Annuae extracting solution mixing and stirring of 15%, add the oligochitosan of 5%, dissolve in dissolution kettle, solution temperature is 25 DEG C, dissolve completely, the concentration adding 40% is the medical ethanol of 75%, adds seed oil of Moringa oleigera and the deionized water of 5%, stir and get final product after stirring.
Gained disinfectant solution color is filbert, and a small amount of flocculent deposit and fine granularity solid are arranged at bottom.Analysis may be that seed oil of Moringa oleigera causes the composition in Herba Artemisiae Annuae extracting solution to there occurs a small amount of flocculation reaction, and the addition of oligochitosan and ethanol is higher, causes or has a small amount of oligochitosan by sedimentation.
Embodiment 2:
A preparation method for natural skin care Wound disinfectant, comprises the steps:
(1) dry artemisia leaf is obtained Herba Artemisiae Annuae extracting solution by decocting cooking method is concentrated, every milliliter of Herba Artemisiae Annuae extracting solution is 0.5-2g containing crude drug amount.
(2) dry leaf of Moringa is obtained leaf of Moringa extracting solution by way of distillation extraction, only adopt the still head distillate of 15 minutes.
(3) by percentage by weight be 20% leaf of Moringa extracting solution and 10% Herba Artemisiae Annuae extracting solution mixing and stirring, add 2% oligochitosan, dissolve in dissolution kettle, solution temperature is 25 DEG C, dissolve completely, the concentration adding 20% is the medical ethanol of 75%, adds seed oil of Moringa oleigera and the deionized water of 3%, stir and get final product after stirring.
Gained disinfectant solution color is light brown, has tiny flocky precipitate bottom solution.Analysis may be the flocculation reaction that seed oil of Moringa oleigera causes.
Embodiment 3:
A preparation method for natural skin care Wound disinfectant, comprises the steps:
(1) dry artemisia leaf is obtained Herba Artemisiae Annuae extracting solution by decocting cooking method is concentrated, every milliliter of Herba Artemisiae Annuae extracting solution is 0.5-2g containing crude drug amount.
(2) dry leaf of Moringa is obtained leaf of Moringa extracting solution by way of distillation extraction, only adopt the still head distillate of 15 minutes.
(3) by percentage by weight be 30% leaf of Moringa extracting solution and 15% Herba Artemisiae Annuae extracting solution mixing and stirring, add 3% oligochitosan, dissolve in dissolution kettle, solution temperature is 30 DEG C, dissolve completely, the concentration adding 30% is the medical ethanol of 75%, adds seed oil of Moringa oleigera and the deionized water of 1%, stir and get final product after stirring.
Gained disinfectant solution color is light brown, the limpid deposit-free of solution.
Test tube method antibacterial tests result shows: Wound disinfectant prepared by embodiment 1,2,3 all has significant antibacterial effect to staphylococcus aureus, streptococcus, escherichia coli, Candida albicans, but the effect of embodiment 2, embodiment 3 is all less than embodiment 1, the oligochitosan that may adopt with embodiment 1 is all often relevant with ethanol, but embodiment 3 is little with embodiment 1 difference.
Table 1 test tube method antibacterial experiment comparing result
| Staphylococcus aureus | Streptococcus | Escherichia coli | Candida albicans | |
| Embodiment 1 | 99.5 | 98.3 | 99.8 | 98.5 |
| Embodiment 2 | 97.6 | 96.9 | 98.6 | 97.4 |
| Embodiment 3 | 99.0 | 97.8 | 99.0 | 98.0 |
Disinfectant liquid for skin prepared by embodiment 1,2,3 all has good experience, and body sense is comfortable, there is no intense stimulus sense on wound, without dry sensation, and with the Herba Artemisiae Annuae fragrance of uniqueness, feels that brains is pure and fresh, happy.Therefore, the natural nonreactive moisturizing disinfectant liquid for skin that the present invention proposes is a kind of safety non-toxic, non-stimulated, has no side effect, does not develop immunity to drugs, the novel disinfectant solution product being directly used in skin wound of skin protection moisturizing.
Above a kind of natural skin care Wound disinfectant provided by the present invention and preparation method thereof is described in detail.Set forth principle of the present invention and embodiment herein by detailed description of the invention, above explanation just understands method of the present invention and core concept thereof for helping.It should be pointed out that for those skilled in the art, under the premise without departing from the principles of the invention, can also carry out some improvement and modification to the present invention, these improve and modify and also fall in the protection domain of the claims in the present invention.
Claims (10)
1. a natural skin care Wound disinfectant, its component and weight content as follows:
2. natural skin care Wound disinfectant according to claim 1, it is characterized in that, wherein said oligochitosan molecular weight is less than 3000.
3. natural skin care Wound disinfectant according to claim 1, is characterized in that, wherein said Herba Artemisiae Annuae extracting solution be dry artemisia leaf by decocting cooking method concentration extraction, every milliliter of Herba Artemisiae Annuae extracting solution is 0.5-2g containing crude drug amount.
4. natural skin care Wound disinfectant according to claim 1, it is characterized in that, wherein said leaf of Moringa extracting solution is that dry leaf of Moringa is extracted by the way of distillation.
5. natural skin care Wound disinfectant according to claim 1, it is characterized in that, wherein said seed oil of Moringa oleigera is that Moringa seed is prepared by aqueous enzymatic method and obtains.
6. natural skin care Wound disinfectant according to claim 1, it is characterized in that, wherein said oligochitosan addition is 3%.
7. natural skin care Wound disinfectant according to claim 1, it is characterized in that, described Herba Artemisiae Annuae extracting solution addition is 15%.
8. natural skin care Wound disinfectant according to claim 1, it is characterized in that, described leaf of Moringa extracting solution addition is 30%.
9. natural skin care Wound disinfectant according to claim 1, it is characterized in that, described seed oil of Moringa oleigera addition is 1%.
10. the preparation method of a natural skin care Wound disinfectant, it is characterized in that, by the above Herba Artemisiae Annuae extracting solution and leaf of Moringa extracting solution mixing and stirring, add oligochitosan, dissolve in dissolution kettle, solution temperature is 25 DEG C-30 DEG C, dissolve completely, add the medical ethanol of 75%, after stirring, add seed oil of Moringa oleigera and deionized water, stir and get final product.
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| CN201510882102.5A CN105267273A (en) | 2015-12-04 | 2015-12-04 | Natural skin-protecting wound disinfectant and preparation method thereof |
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Cited By (3)
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| CN105998105A (en) * | 2016-08-01 | 2016-10-12 | 昆明医科大学第附属医院 | Externally applied medicine for treating gout |
| CN106420381A (en) * | 2016-08-08 | 2017-02-22 | 辛成业 | Novel applications of artemisinin ingredients or composition of artemisinin ingredients in skin care |
| CN106692171A (en) * | 2017-01-18 | 2017-05-24 | 佛山市南海东方澳龙制药有限公司 | Compound external selamectin drops for pets as well as method and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103356999A (en) * | 2013-07-20 | 2013-10-23 | 日照众生海洋生物科技有限公司 | Novel marine organism washing-free disinfection solution and its application |
Non-Patent Citations (2)
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| 刘子记等: "特色植物辣木的应用价值及发展前景分析", 《热带作物学报》 * |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105998105A (en) * | 2016-08-01 | 2016-10-12 | 昆明医科大学第附属医院 | Externally applied medicine for treating gout |
| CN106420381A (en) * | 2016-08-08 | 2017-02-22 | 辛成业 | Novel applications of artemisinin ingredients or composition of artemisinin ingredients in skin care |
| CN106692171A (en) * | 2017-01-18 | 2017-05-24 | 佛山市南海东方澳龙制药有限公司 | Compound external selamectin drops for pets as well as method and application thereof |
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