CN105250996A - Biological agent for treating iron-deficiency anemia, preparation method thereof and purpose thereof - Google Patents

Biological agent for treating iron-deficiency anemia, preparation method thereof and purpose thereof Download PDF

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CN105250996A
CN105250996A CN201510726765.8A CN201510726765A CN105250996A CN 105250996 A CN105250996 A CN 105250996A CN 201510726765 A CN201510726765 A CN 201510726765A CN 105250996 A CN105250996 A CN 105250996A
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extract
biological
parts
iron
deficiency anemia
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许宏华
韩超
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SHANGHAI SHANLIJIAN BIOTECHNOLOGY CO Ltd
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SHANGHAI SHANLIJIAN BIOTECHNOLOGY CO Ltd
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Abstract

The invention relates to a biological agent for treating iron-deficiency anemia, a preparation method thereof and a purpose thereof. The biological agent for treating iron-deficiency anemia is prepared from the following components in parts by weight: 20 to 30 parts of extracts from angelica, 20 to 30 parts of radix rehmanniae preparata extracts, 15 to 20 parts of acerola cherry extracts, 15 to 20 parts of collagen and 5 to 10 parts of iron supplements. During preparation, all the components are added in a three-dimensional mixer, stirred for 15 to 30min and screened by a 40 to 80 mesh sieve, and after the steps are repeated for twice, the biological agent can be obtained. Compared with the prior art, the biological agent can remarkably improve the anemia symptom of organisms, and is simple in preparation technology, quick in taking effect, wide in target users, little in dosage, few in side effects, good in stability, long in quality guarantee period, convenient to take, easy to carry, low in cost and suitable for large-scale production.

Description

A kind of biological preparation for the treatment of iron deficiency anemia and preparation method thereof and purposes
Technical field
The invention belongs to pharmaceutical technology, relate to a kind of biological preparation for the treatment of iron deficiency anemia and preparation method thereof and purposes.
Background technology
Iron deficiency anemia (IDA) is one of modal chronic disease of the mankind, is one of large food deficiency disease in the world four that World Health Organization (WHO) confirms.Iron deficiency anemia is due to body storage ferrum and absorbs ferrum obstacle, and have impact on a kind of microcyte, the anemia with low hemoglobin caused by synthesis of haemachrome, is type modal in anemia.Women, due to factors such as menstruation, gestation, childbirth, suckling, contraceptions, becomes the group of people at high risk of anemia.It is reported, in the prevalence of developing country gravid woman anemia up to 40%-60%, caused the great attention of international community.
According to iron deficiency anemia clinical manifestation, surely belong to the category such as " vanity " in Chinese medicine, " deficient ", " sallow ", " general edema with yellowish skin " and " general edema with yellowish tinge of the skin ".Clinical symptoms shallow complexion and pale, tired breath is weak, loss of appetite, and Yuan gas of feeling sick, abdominal distention is suffered from diarrhoea, and dysphagia, dizziness and tinnitus, very then faints, and slightly activity can be out of breath, and cardiopalmus is not transported.Clinical sign is that patients on long-term can have fingernail shrinkage, rough, coelonychia, xerosis cutis, trichoxerosis come off, and tachycardia, heart is beaten strongly, and apex or pulmonary area can hear systolic murmur.Occur that severe anemia then can cause congestive heart failure, also edema can occur, also break with glossitis bicker.Common complication has the anemia of severe persistent to cause anemic cardiopathy, even heart failure.As can be seen here, ferrous anemia can directly affect the healthy of people.
Application number be 200410027058.1 Chinese invention patent disclose a kind of qi invigorating blood maintaining particle, be made up of Sanguis sus domestica extract and the Radix Astragali, Fructus Jujubae extract and sucrose, dextrin etc., Sanguis sus domestica extract is that fresh porcine blood is carried out centrifugalize, discards blood plasma, immersion etc., drying forms, add the Radix Astragali, the concentrated extract of Fructus Jujubae and the granulation such as sucrose, dextrin again, dry and obtain.
Application number be 201110033051.0 Chinese invention patent disclose a kind of Chinese medicine composition for the treatment of iron deficiency anemia and preparation method thereof, wherein, the medicament be made up of the crude drug of following weight proportioning of Chinese medicine composition: Melanteritum 2.25-9g, Radix Astragali 135-540g, Fructus Crataegi 135-540g, new Colla Corii Asini 45-180g and Fructus Jujubae 45-180g; During preparation, the Radix Astragali, Fructus Crataegi, Fructus Jujubae decoct with water twice, each 2 hours, amount of water is respectively 10 times, 8 times, collecting decoction, is concentrated into the clear paste that relative density is 1.08, by volume calculate, add equimultiple 95% ethanol, leave standstill 48 hours or centrifugal, supernatant or centrifugal liquid are concentrated into the clear paste that relative density is 1.29-1.31, filter, Melanteritum, new Colla Corii Asini are pulverized, and fine powder mixes with above-mentioned clear paste, Icing Sugar, dextrin, make granule, to obtain final product.
Summary of the invention
Object of the present invention be exactly in order to overcome above-mentioned prior art exist defect and a kind of biological preparation for the treatment of iron deficiency anemia and preparation method thereof and purposes are provided, dosage in order to solve the existence of existing medicine is large, flavour of a drug weight, mouthfeel is bad, be difficult to long-term taking, therapeutic effect is slow, the technical problem of pharmacodynamic stability difference.
Object of the present invention can be achieved through the following technical solutions:
Treat a biological preparation for iron deficiency anemia, this biological preparation comprises following component and weight portion content: Radix Angelicae Sinensis extract 20-30 part, Radix Rehmanniae Preparata extract 20-30 part, Malpighia glabra L. extract 15-20 part, collagen protein 15-20 part and supplements-iron 5-10 part.
Described biological preparation comprises following component and weight portion content: Radix Angelicae Sinensis extract 25-28 part, Radix Rehmanniae Preparata extract 24-26 part, Malpighia glabra L. extract 16-18 part, collagen protein 16-18 part and supplements-iron 7-8 part.
The preparation method of described Radix Angelicae Sinensis extract is: joined by Radix Angelicae Sinensis in the 50-60% alcoholic solution of 6-8 times amount, in 50-60 DEG C of reflux, extract, 2 times, obtains extracting solution, then in 55-65 DEG C of concentrate drying, i.e. obtained described Radix Angelicae Sinensis extract.
The preparation method of described Radix Rehmanniae Preparata extract is: joined by Radix Rehmanniae Preparata in the 40-60% alcoholic solution of 6-8 times amount, in 50-60 DEG C of reflux, extract, 2 times, obtains extracting solution, then in 55-65 DEG C of concentrate drying, i.e. obtained described Radix Rehmanniae Preparata extract.
Described Malpighia glabra L. extract is commercially available Malpighia glabra L. extract, and in this Malpighia glabra L. extract, ascorbic content is greater than 20%.
Described supplements-iron is ferrous sulfate or iron-amino acid chelate.
The dosage form of described biological preparation is tablet, granule, pill, powder, the one sucked in agent or powder.
Treat a preparation method for the biological preparation of iron deficiency anemia, the method specifically comprises the following steps:
(1) get the raw materials ready by following component and weight portion content:
Radix Angelicae Sinensis extract 20-30 part, Radix Rehmanniae Preparata extract 20-30 part, Malpighia glabra L. extract 15-20 part, collagen protein 15-20 part and supplements-iron 5-10 part;
(2) join in three-dimensional mixer by step (1) each component, mixing time is 15-30 minute, crosses 40-80 mesh sieve, repeats twice, i.e. obtained described biological preparation.
Treat a purposes for the biological preparation of iron deficiency anemia, the purposes of described biological preparation in the medicine of preparation treatment iron deficiency anemia.
The traditional Chinese medical science is thought, insufficiency of the spleen is the key of anemia, therefore invigorating the spleen and benefiting QI hemopoietic is main method for the treatment of.Because of the spleen being the foundation of acquired constitution, source of generating QI and blood, the strong then QI and blood source of spleen is sufficient." qi as the commander of blood, blood being the mother of qi ", blood deficiency is with the deficiency of vital energy in various degree, therefore formula of the present invention is using Radix Angelicae Sinensis extract, Radix Rehmanniae Preparata extract as combination drug.
Described Radix Angelicae Sinensis extract is that one is invigorated blood circulation for enriching blood, menstruction regulating and pain relieving, loosening bowel to relieve constipation, blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, the plant extract of ulcer sores.It is warm in nature, nontoxic, warming middle-JIAO to relieve pain, mends all gas, broken stagnant blood, supports fresh blood, is rich in trace element, can effective blood vessel dilating, quickening blood circulation.
Described Radix Rehmanniae Preparata extract has YIN nourishing of enriching blood, life essence-filling, marrow-benefitting effect, can be used for blood deficiency and yellow complexion, dizzy, palpitation and insomnia, menoxenia, the diseases such as metrorrhagia, it can promote the recovery of body erythrocyte, hemoglobin, and can accelerate propagation, the differentiation of pluripotential hemopoietic stem cell (CFU-S), bone marrow hemopoietic progenitor cell of red blood cell line (CFU-E), and it has activation to plasminogen, effectively can suppress the formation of thrombosis.
Described Malpighia glabra L. extract is rich in vitamin C, and containing vitamin A, B 1, B 2, E, P, niacin, the defying age factor (SOD), calcium, ferrum, zinc, the multiple nutrients material such as potassium and protein, be of high nutritive value, there is diaphoresis, QI invigorating, dispel the wind, effect of rash, it can promote that body is to irony, calcareous absorption, collagen protein synthesis can also be promoted, can eat for a long time, not any side effect.
In pharmacological action, Malpighia glabra L. extract is rich in vitamin C effectively can promote that body is to the absorption efficiency of irony.
Described collagen protein is the very important protein of one of human body, mainly be present in connective tissue, there is very strong stretch capability, it is the Main Ingredients and Appearance of ligament and flesh key, its network structure be intertwined to form at connective tissue and elastin laminin and GL-PP, vessel wall elasticity can be kept, prevent angiorrhexis, thromboembolism, simultaneously, collagen protein also has Blood clotting, after collagen and Platelet, cause the carrying out of the follow-up a series of processes be associated with blood accumulation, thus can blood coagulation rapidly.
Compared with prior art, the present invention has following characteristics:
1) adopt suitable proportioning, Malpighia glabra L. extract, collagen protein and supplements-iron are carried out compound and can promote the absorption of body to irony and the formation of hemoglobin, significantly can improve the Anemia of body;
2) using Radix Angelicae Sinensis extract, Radix Rehmanniae Preparata extract as combination drug, two taste Chinese medicines all have the effect of blood yiqi, and itself and supplements-iron have excellent synergism, and can effectively improve supplements-iron stimulates gastrointestinal, heterogeneous adjustment, effectively can improve Anemia;
3) preparation technology is simple, instant effect, and be suitable for crowd extensive, dosage is few, few side effects, good stability, long shelf-life, takes medicine convenient and is easy to carry about with one, with low cost, is applicable to large-scale production.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is described in detail.
Embodiment 1:
The biological preparation of the present embodiment treatment iron deficiency anemia, comprises following component and weight portion content: Radix Angelicae Sinensis extract 25 parts, Radix Rehmanniae Preparata extract 28 parts, Malpighia glabra L. extract 16 parts, collagen protein 16 parts and supplements-iron 7 parts.
Wherein, the preparation method of Radix Angelicae Sinensis extract is: joined by Radix Angelicae Sinensis in 60% alcoholic solution of 8 times amount, in 60 DEG C of reflux, extract, 2 times, obtains extracting solution, then in 65 DEG C of concentrate dryings, i.e. obtained Radix Angelicae Sinensis extract.
The preparation method of Radix Rehmanniae Preparata extract is: joined by Radix Rehmanniae Preparata in 60% alcoholic solution of 8 times amount, in 60 DEG C of reflux, extract, 2 times, obtains extracting solution, then in 65 DEG C of concentrate dryings, i.e. obtained Radix Rehmanniae Preparata extract.
Malpighia glabra L. extract is commercially available Malpighia glabra L. extract, and in this Malpighia glabra L. extract, ascorbic content is greater than 20%.
Supplements-iron is commercially available ferrous sulfate.
The preparation method of the biological preparation of the present embodiment treatment iron deficiency anemia, specifically comprises the following steps:
(1) get the raw materials ready by following component and weight portion content:
Radix Angelicae Sinensis extract 25 parts, Radix Rehmanniae Preparata extract 28 parts, Malpighia glabra L. extract 16 parts, collagen protein 16 parts and supplements-iron 7 parts;
(2) join in three-dimensional mixer by step (1) each component, mixing time is 30 minutes, crosses 80 mesh sieves, repeats twice, i.e. obtained biological preparation.
The present embodiment gained biological preparation makes tablet through following process.
When carrying out clinical research, select 60 examples to suffer from the patient of iron deficiency anemia, the age 18-65 year between, be divided into matched group at random according to symptom weight and take group, often group is 30 examples, takes group and adopts this enforcement biological preparation tablet.Consider the principal element affecting observed result as far as possible, as age, sex, the course of disease etc., carry out harmony inspection, to guarantee, between examination group, there is comparability.Experimenter takes 2 times everyone every day, each 2, uses warm water delivery service.Duration of test normal diet, does not change original dietary habit, and the medicine of other treatment iron deficiency anemia of stopping using and health product, viewing duration is 30 days.
Result of the test is as shown in table 1:
Front and back hemoglobin taken by table 1 and RBC number change is compared
From table 1 result of the test, the present embodiment biological preparation is adopted to treat the evident in efficacy of iron deficiency anemia, patient takes 30 days, the content of hemoglobin of body can reach 103.31 ± 37.26*g/L, be significantly higher than 77.79 ± 29.37g/L of matched group, this also absolutely proves that biological preparation of the present invention can effectively improve Anemia symptom, has good using value.
Embodiment 2:
The biological preparation of the present embodiment treatment iron deficiency anemia, comprises following component and weight portion content: Radix Angelicae Sinensis extract 20 parts, Radix Rehmanniae Preparata extract 30 parts, Malpighia glabra L. extract 23 parts, collagen protein 20 parts and supplements-iron 10 parts.
Wherein, the preparation method of Radix Angelicae Sinensis extract is: joined by Radix Angelicae Sinensis in 50% alcoholic solution of 6 times amount, in 50 DEG C of reflux, extract, 2 times, obtains extracting solution, then in 55 DEG C of concentrate dryings, i.e. obtained Radix Angelicae Sinensis extract.
The preparation method of Radix Rehmanniae Preparata extract is: joined by Radix Rehmanniae Preparata in 60% alcoholic solution of 6 times amount, in 60 DEG C of reflux, extract, 2 times, obtains extracting solution, then in 55 DEG C of concentrate dryings, i.e. obtained Radix Rehmanniae Preparata extract.
Malpighia glabra L. extract is commercially available Malpighia glabra L. extract, and in this Malpighia glabra L. extract, ascorbic content is greater than 20%.
Supplements-iron is commercially available iron-amino acid chelate.
The preparation method of the biological preparation of the present embodiment treatment iron deficiency anemia, specifically comprises the following steps:
(1) get the raw materials ready by following component and weight portion content:
Radix Angelicae Sinensis extract 20 parts, Radix Rehmanniae Preparata extract 30 parts, Malpighia glabra L. extract 23 parts, collagen protein 20 parts and supplements-iron 10 parts;
(2) join in three-dimensional mixer by step (1) each component, mixing time is 25 minutes, crosses 60 mesh sieves, repeats twice, i.e. obtained biological preparation.
The present embodiment gained biological preparation makes granule through following process.
Embodiment 3:
The biological preparation of the present embodiment treatment iron deficiency anemia, comprises following component and weight portion content: Radix Angelicae Sinensis extract 30 parts, Radix Rehmanniae Preparata extract 20 parts, Malpighia glabra L. extract 15 parts, collagen protein 15 parts and supplements-iron 5 parts.
Wherein, the preparation method of Radix Angelicae Sinensis extract is: joined by Radix Angelicae Sinensis in 55% alcoholic solution of 7 times amount, in 58 DEG C of reflux, extract, 2 times, obtains extracting solution, then in 60 DEG C of concentrate dryings, i.e. obtained Radix Angelicae Sinensis extract.
The preparation method of Radix Rehmanniae Preparata extract is: joined by Radix Rehmanniae Preparata in 50% alcoholic solution of 7 times amount, in 58 DEG C of reflux, extract, 2 times, obtains extracting solution, then in 60 DEG C of concentrate dryings, i.e. obtained Radix Rehmanniae Preparata extract.
Malpighia glabra L. extract is commercially available Malpighia glabra L. extract, and in this Malpighia glabra L. extract, ascorbic content is greater than 20%.
Supplements-iron is commercially available iron-amino acid chelate.
The preparation method of the biological preparation of the present embodiment treatment iron deficiency anemia, specifically comprises the following steps:
(1) get the raw materials ready by following component and weight portion content:
Radix Angelicae Sinensis extract 30 parts, Radix Rehmanniae Preparata extract 20 parts, Malpighia glabra L. extract 15 parts, collagen protein 15 parts and supplements-iron 5 parts;
(2) join in three-dimensional mixer by step (1) each component, mixing time is 15 minutes, crosses 40 mesh sieves, repeats twice, i.e. obtained biological preparation.
The present embodiment gained biological preparation makes pill through following process.
Embodiment 4:
The biological preparation of the present embodiment treatment iron deficiency anemia, comprises following component and weight portion content: Radix Angelicae Sinensis extract 27 parts, Radix Rehmanniae Preparata extract 25 parts, Malpighia glabra L. extract 17 parts, collagen protein 17 parts and supplements-iron 8 parts.
Wherein, the preparation method of Radix Angelicae Sinensis extract is: joined by Radix Angelicae Sinensis in 58% alcoholic solution of 8 times amount, in 60 DEG C of reflux, extract, 2 times, obtains extracting solution, then in 55 DEG C of concentrate dryings, i.e. obtained Radix Angelicae Sinensis extract.
The preparation method of Radix Rehmanniae Preparata extract is: joined by Radix Rehmanniae Preparata in 46% alcoholic solution of 6 times amount, in 60 DEG C of reflux, extract, 2 times, obtains extracting solution, then in 56 DEG C of concentrate dryings, i.e. obtained Radix Rehmanniae Preparata extract.
Malpighia glabra L. extract is commercially available Malpighia glabra L. extract, and in this Malpighia glabra L. extract, ascorbic content is greater than 20%.
Supplements-iron is commercially available ferrous sulfate.
The preparation method of the biological preparation of the present embodiment treatment iron deficiency anemia, specifically comprises the following steps:
(1) get the raw materials ready by following component and weight portion content:
Radix Angelicae Sinensis extract 27 parts, Radix Rehmanniae Preparata extract 25 parts, Malpighia glabra L. extract 17 parts, collagen protein 17 parts and supplements-iron 8 parts;
(2) join in three-dimensional mixer by step (1) each component, mixing time is 25 minutes, crosses 70 mesh sieves, repeats twice, i.e. obtained biological preparation.
The present embodiment gained biological preparation makes powder through following process.
Embodiment 5:
The biological preparation of the present embodiment treatment iron deficiency anemia, comprises following component and weight portion content: Radix Angelicae Sinensis extract 25 parts, Radix Rehmanniae Preparata extract 24 parts, Malpighia glabra L. extract 16 parts, collagen protein 18 parts and supplements-iron 8 parts.
Wherein, the preparation method of Radix Angelicae Sinensis extract is: joined by Radix Angelicae Sinensis in 52% alcoholic solution of 6 times amount, in 52 DEG C of reflux, extract, 2 times, obtains extracting solution, then in 62 DEG C of concentrate dryings, i.e. obtained Radix Angelicae Sinensis extract.
The preparation method of Radix Rehmanniae Preparata extract is: joined by Radix Rehmanniae Preparata in 56% alcoholic solution of 8 times amount, in 52 DEG C of reflux, extract, 2 times, obtains extracting solution, then in 62 DEG C of concentrate dryings, i.e. obtained Radix Rehmanniae Preparata extract.
Malpighia glabra L. extract is commercially available Malpighia glabra L. extract, and in this Malpighia glabra L. extract, ascorbic content is greater than 20%.
Supplements-iron is commercially available ferrous sulfate.
The preparation method of the biological preparation of the present embodiment treatment iron deficiency anemia, specifically comprises the following steps:
(1) get the raw materials ready by following component and weight portion content:
Radix Angelicae Sinensis extract 25 parts, Radix Rehmanniae Preparata extract 24 parts, Malpighia glabra L. extract 16 parts, collagen protein 18 parts and supplements-iron 8 parts;
(2) join in three-dimensional mixer by step (1) each component, mixing time is 20 minutes, crosses 60 mesh sieves, repeats twice, i.e. obtained biological preparation.
The present embodiment gained biological preparation is made through following process and is sucked agent.
Embodiment 6:
The biological preparation of the present embodiment treatment iron deficiency anemia, comprises following component and weight portion content: Radix Angelicae Sinensis extract 28 parts, Radix Rehmanniae Preparata extract 26 parts, Malpighia glabra L. extract 18 parts, collagen protein 16 parts and supplements-iron 7 parts.
Wherein, the preparation method of Radix Angelicae Sinensis extract is: joined by Radix Angelicae Sinensis in 52% alcoholic solution of 6 times amount, in 52 DEG C of reflux, extract, 2 times, obtains extracting solution, then in 62 DEG C of concentrate dryings, i.e. obtained Radix Angelicae Sinensis extract.
The preparation method of Radix Rehmanniae Preparata extract is: joined by Radix Rehmanniae Preparata in 56% alcoholic solution of 8 times amount, in 52 DEG C of reflux, extract, 2 times, obtains extracting solution, then in 62 DEG C of concentrate dryings, i.e. obtained Radix Rehmanniae Preparata extract.
Malpighia glabra L. extract is commercially available Malpighia glabra L. extract, and in this Malpighia glabra L. extract, ascorbic content is greater than 20%.
Supplements-iron is commercially available ferrous sulfate.
The preparation method of the biological preparation of the present embodiment treatment iron deficiency anemia, specifically comprises the following steps:
(1) get the raw materials ready by following component and weight portion content:
Radix Angelicae Sinensis extract 28 parts, Radix Rehmanniae Preparata extract 26 parts, Malpighia glabra L. extract 18 parts, collagen protein 16 parts and supplements-iron 7 parts;
(2) join in three-dimensional mixer by step (1) each component, mixing time is 25 minutes, crosses 50 mesh sieves, repeats twice, i.e. obtained biological preparation.
The present embodiment gained biological preparation makes powder through following process.
Embodiment 7:
The biological preparation of the present embodiment treatment iron deficiency anemia, comprises following component and weight portion content: Radix Angelicae Sinensis extract 22 parts, Radix Rehmanniae Preparata extract 27 parts, Malpighia glabra L. extract 20 parts, collagen protein 20 parts and supplements-iron 6 parts.
Wherein, the preparation method of Radix Angelicae Sinensis extract is: joined by Radix Angelicae Sinensis in 60% alcoholic solution of 8 times amount, in 52 DEG C of reflux, extract, 2 times, obtains extracting solution, then in 65 DEG C of concentrate dryings, i.e. obtained Radix Angelicae Sinensis extract.
The preparation method of Radix Rehmanniae Preparata extract is: joined by Radix Rehmanniae Preparata in 60% alcoholic solution of 8 times amount, in 52 DEG C of reflux, extract, 2 times, obtains extracting solution, then in 65 DEG C of concentrate dryings, i.e. obtained Radix Rehmanniae Preparata extract.
Malpighia glabra L. extract is commercially available Malpighia glabra L. extract, and in this Malpighia glabra L. extract, ascorbic content is greater than 20%.
Supplements-iron is commercially available iron-amino acid chelate.
The preparation method of the biological preparation of the present embodiment treatment iron deficiency anemia, specifically comprises the following steps:
(1) get the raw materials ready by following component and weight portion content:
Radix Angelicae Sinensis extract 22 parts, Radix Rehmanniae Preparata extract 27 parts, Malpighia glabra L. extract 20 parts, collagen protein 20 parts and supplements-iron 6 parts;
(2) join in three-dimensional mixer by step (1) each component, mixing time is 30 minutes, crosses 80 mesh sieves, repeats twice, i.e. obtained biological preparation.
The present embodiment gained biological preparation makes granule through following process.

Claims (9)

1. treat the biological preparation of iron deficiency anemia for one kind, it is characterized in that, this biological preparation comprises following component and weight portion content: Radix Angelicae Sinensis extract 20-30 part, Radix Rehmanniae Preparata extract 20-30 part, Malpighia glabra L. extract 15-20 part, collagen protein 15-20 part and supplements-iron 5-10 part.
2. a kind of biological preparation for the treatment of iron deficiency anemia according to claim 1, it is characterized in that, described biological preparation comprises following component and weight portion content: Radix Angelicae Sinensis extract 25-28 part, Radix Rehmanniae Preparata extract 24-26 part, Malpighia glabra L. extract 16-18 part, collagen protein 16-18 part and supplements-iron 7-8 part.
3. a kind of biological preparation for the treatment of iron deficiency anemia according to claim 1, it is characterized in that, the preparation method of described Radix Angelicae Sinensis extract is: joined by Radix Angelicae Sinensis in the 50-60% alcoholic solution of 6-8 times amount, in 50-60 DEG C of reflux, extract, 2 times, obtain extracting solution, again in 55-65 DEG C of concentrate drying, i.e. obtained described Radix Angelicae Sinensis extract.
4. a kind of biological preparation for the treatment of iron deficiency anemia according to claim 1, it is characterized in that, the preparation method of described Radix Rehmanniae Preparata extract is: joined by Radix Rehmanniae Preparata in the 40-60% alcoholic solution of 6-8 times amount, in 50-60 DEG C of reflux, extract, 2 times, obtain extracting solution, again in 55-65 DEG C of concentrate drying, i.e. obtained described Radix Rehmanniae Preparata extract.
5. a kind of biological preparation for the treatment of iron deficiency anemia according to claim 1, is characterized in that, described Malpighia glabra L. extract is commercially available Malpighia glabra L. extract, and in this Malpighia glabra L. extract, ascorbic content is greater than 20%.
6. a kind of biological preparation for the treatment of iron deficiency anemia according to claim 1, is characterized in that, described supplements-iron is ferrous sulfate or iron-amino acid chelate.
7. a kind of biological preparation for the treatment of iron deficiency anemia according to claim 1, is characterized in that, the dosage form of described biological preparation is tablet, granule, pill, powder, the one sucked in agent or powder.
8. a preparation method for the biological preparation for the treatment of iron deficiency anemia as claimed in claim 1, it is characterized in that, the method specifically comprises the following steps:
(1) get the raw materials ready by following component and weight portion content:
Radix Angelicae Sinensis extract 20-30 part, Radix Rehmanniae Preparata extract 20-30 part, Malpighia glabra L. extract 15-20 part, collagen protein 15-20 part and supplements-iron 5-10 part;
(2) join in three-dimensional mixer by step (1) each component, mixing time is 15-30 minute, crosses 40-80 mesh sieve, repeats twice, i.e. obtained described biological preparation.
9. a purposes for the biological preparation for the treatment of iron deficiency anemia as claimed in claim 1, is characterized in that, the purposes of described biological preparation in the medicine of preparation treatment iron deficiency anemia.
CN201510726765.8A 2015-10-30 2015-10-30 Biological agent for treating iron-deficiency anemia, preparation method thereof and purpose thereof Pending CN105250996A (en)

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