CN105233347A - 3D-printed gradient-diameter medical porous metal bone tissue scaffold - Google Patents
3D-printed gradient-diameter medical porous metal bone tissue scaffold Download PDFInfo
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- CN105233347A CN105233347A CN201510725398.XA CN201510725398A CN105233347A CN 105233347 A CN105233347 A CN 105233347A CN 201510725398 A CN201510725398 A CN 201510725398A CN 105233347 A CN105233347 A CN 105233347A
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Abstract
The invention discloses a 3D-printed gradient-diameter medical porous metal bone tissue scaffold and aims to solve the problems that a single repeated microporous structure in the prior art is adverse to bone tissue ingrowth and a bone tissue implant has difficulty in bony healing with self-bones. The scaffold is in a hexahedron structure as a whole, and comprises components A, components B and components C in tight arrangement, wherein the components A are arrayed on an outermost layer of the hexahedron structure; the components B are arrayed on a secondary outer layer; and the components C are arrayed on the innermost layer; all the components A, B and C are in a hexahedron frame structure; the pore diameter of the components A is greater than that of the components B; and the pore diameter of the components B is greater than that of the components C. Through the reinforcing structural design, the gradient-pore tissue engineering bone scaffold is produced; through regulating the ingrowth of bone tissues, fibroblasts and the like by gradient-change pores, the optimal bone healing can be achieved finally.
Description
Technical field
The present invention relates to a kind of 3D and print medical metal implant, be specifically related to a kind of 3D and print the medical porous metal tissue scaffold design in gradient aperture, it is conducive to osseous tissue and grows into, and promotes bony union.
Background technology
3D prints and prepares the great significance of porous metals for tissue engineered bone, decreases the damage because autologous bone transplanting causes patient body, it also avoid the cost issues that allogenic bone transplantation is high simultaneously.The orthopaedics implants such as metal alloy mortar cup, femoral shaft, spinal column and skull that Sweden Arcam is successfully prepared by 3D printing technique, wherein partially porous metal alloy Bone Defect Repari implant is applied clinical.
Porous metals print the current porous metals relying on electronic torch melting (EBM) 3D printing technique to manufacture as Arcam company of Sweden etc. of main employing, micropore size can be accurately controlled by computer design structure, porosity, duct trend and UNICOM's situation, the most I in its aperture reaches 400 microns, and porosity is maximum reaches 85%.And selective laser melting technique (SLM) can reach higher precision (100 microns), timbering material internal structure can be controlled more accurately.
And the micropore of 3D printing is now single, mostly be the repetition of single structure, the aperture of fixed size and single duct UNICOM structure often, and this does not conform to body bone tissue trabecular bone structure, and be unfavorable for that osseous tissue is grown into, easily cause osseous tissue and become fiber and grow into simultaneously, a large amount of fibrous tissue causes fiber to heal but not knitting.And grow into along with tissue, larger space of creeping must be needed, and traditional design scheme also results in osseous tissue later stage of growing into occurs the problem of growing space deficiency.EBM or SLM enough accurately can control internal structure, but at present the attention of structural design not, is not given full play to 3D and prints the advantage accurately controlling internal structure, and the structure of single repetition is also unfavorable for knitting.
Summary of the invention
The microcellular structure that the object of the invention is to overcome the single repetition of prior art is unfavorable for that osseous tissue is grown into, bone tissue implant is difficult to the problem reaching bony union with self bone, a kind of 3D is provided to print the medical porous metal tissue scaffold design in gradient aperture, strengthen structural design, make the tissue engineered bone support of hole gradual change, regulate and control osseous tissue by the hole of gradual change in gradient and become growing into of fiber etc., finally reaching best knitting.
The present invention is achieved by the following scheme:
A kind of 3D prints the medical porous metal tissue scaffold design in gradient aperture, and its entirety is hexahedron structure, is made up of assembly A, assembly B and assembly C close-packed arrays, and assembly A array is in hexahedron structure outermost layer, and assembly B array is in secondary skin, and assembly C array is in innermost layer; Assembly A, assembly B, assembly C are hexahedron frame structure, and the aperture of assembly A is greater than the aperture of assembly B, and the aperture of assembly B is greater than the aperture of assembly C.
Described a kind of 3D prints the medical porous metal tissue scaffold design in gradient aperture, wherein, assembly C is made up of support column and guide rod, many support columns connect and compose the arris of hexahedron frame structure, guide rod is positioned at the line of centres in every relative two faces of hexahedron frame structure, and the guide rod of adjacent component is connected to each other; Assembly A and assembly B is formed by support column, guide rod and grille, and grille is positioned at the diagonal positions of hexahedron frame structure each, and in assembly B, the quantity of grille is less than the quantity of grille in assembly A.
Described a kind of 3D prints the medical porous metal tissue scaffold design in gradient aperture, and wherein, in assembly B, the quantity of grille is the half of the quantity of grille in assembly A.
Described a kind of 3D prints the medical porous metal tissue scaffold design in gradient aperture, and wherein, in assembly A, hexahedron frame structure each is provided with two grilles, and hexahedron frame structure each is only established a grille in assembly B.
Compared with prior art, the present invention has the following advantages:
The present invention emphatically design 3D prints the fine structure of metal tissue scaffold design, designs 3 kinds of different assemblies, and according to the change of the arrangement adjustment hole of different assembly, often kind of assembly comprises support column, grille and guide rod composition respectively.The present invention by the length of adjustment support column, and then can change the length of grille successively, thus changes pore area and then change pore size.Therefore the present invention can adjust aperture simply and easily.
Tissue scaffold design of the present invention, based on hexahedron structure, in order to reach the object of hole gradual change, devises grille, changes the aperture of hole with grille.
The present invention, in order to promote that cell tissue is creeped, for example tissue scaffold design devises guide rod, plays emphatically the effect guiding cell migration to creep.More being conducive to osseous tissue grows in metal rack along guide rod direction, makes to combine closely between tissue and support, reaches the object of bony union.
The present invention is the medical porous metal tissue scaffold design in gradient aperture of aperture gradual change, is conducive to cell tissue metal tissue scaffold design of reasonably growing in order inner.The length of support column, grille, guide rod can adjust simultaneously, and drives pore size to change, and method is simply effective, can produce the gradual change hole metal tissue scaffold design of different pore size gradient.
Accompanying drawing explanation
Fig. 1 is the overall structure simplified schematic diagram that 3D of the present invention prints the medical porous metal tissue scaffold design in gradient aperture;
Fig. 2 is that the present invention builds gradient pore structured assembly A structural representation.
Fig. 3 is that the present invention builds gradient pore structured assembly B structural representation.
Fig. 4 is that the present invention builds gradient pore structured assembly C-structure schematic diagram.
In figure:
1-support column, 2-grille, 3-guide rod.
Detailed description of the invention
In conjunction with the accompanying drawings, the present invention is further detailed explanation.Accompanying drawing is the schematic diagram of simplification, only basic structure of the present invention is described in a schematic way, and therefore it only shows the formation relevant with the present invention.
Figure 1 shows that 3D prints the structural representation of the medical porous metal tissue scaffold design in gradient aperture, this support complete structure is hexahedron structure, Fig. 1 omits view for part, only retains three mutually orthogonal alien invasion, and Fig. 2 to Fig. 4 is three kinds of assemblies of this support of composition.3D prints the medical porous metal tissue scaffold design in gradient aperture and is made up of assembly A, assembly B and assembly C, assembly A, assembly B, assembly C lay respectively at the outer middle inner layer surface of stereochemical structure, namely assembly A array is in outermost layer, there is provided minimum aperture, assembly B array, in secondary skin, provides intermediate aperture, assembly C array is in innermost layer, there is provided maximum diameter of hole, namely assembly A aperture is greater than the aperture of assembly B, and the aperture of assembly B is greater than the aperture of assembly C.
In the present embodiment, this support is the six rank cube structures of 6*6*6, and assembly A is distributed on cube structure outermost one deck, and assembly B is distributed on time outer one deck, and it is two-layer that assembly C is distributed on innermost layer.
Assembly A, assembly B, assembly C are hexahedron frame structure, and assembly C is made up of support column 1 and guide rod 3, and many support columns 1 connect and compose the arris of hexahedron frame structure; Assembly A and assembly B is formed by support column 1, guide rod 3 and grille 2, and in assembly B, the quantity of grille 2 is less than the quantity of grille 2 in assembly A.
Support column 1 is the arris of hexahedron frame structure, and each support column 1 is interconnected to constitute the main body stereochemical structure that 3D prints the medical porous metal tissue scaffold design in gradient aperture.
Grille 2 is positioned at the diagonal positions of hexahedron frame structure each, for splitting the hole of metal tissue scaffold design, aperture can be divided into large, medium and small three kinds by the quantity controlling grille.In the present embodiment, the difference of assembly A and assembly B is, hexahedral each is arranged two grilles 2, and hexahedral each is only arranged a grille 2 in assembly B in assembly A.
Guide rod 3 is the total composition of assembly A, assembly B, assembly C, and be positioned at the line of centres in every relative two faces of hexahedron frame structure, the guide rod 3 of adjacent component is connected to each other, for growing into of cell tissue provides guide effect.In order to avoid number of lines is too much in Fig. 1, not shown guide rod 3.
The present invention 3D different from the past prints metal tissue scaffold design, conventional stereo architecture basics improves, makes metal tissue scaffold design have the characteristic of hole gradual change.
As shown in Figure 1 for regular hexahedron metal tissue scaffold design, if support column 1 length is 1.4mm, this support outermost one deck is made up of assembly A, the pore area 0.49mm in assembly A
2, then hole effective aperture is about 400um.Secondary skin is made up of assembly B, and pore area is 0.98mm
2, then effective aperture is about 560um.Innermost layer is made up of assembly C, and pore area is 1.96mm
2, then effective aperture is 790um.
If support column 1 length is 2mm, this support outermost one deck is made up of assembly A, the pore area 1mm in assembly A
2, then hole effective aperture is about 556um.Secondary skin is made up of assembly B, and pore area is 2mm
2, then effective aperture is about 798um.Innermost layer is made up of assembly C, and pore area is 4mm
2, then effective aperture is that the visible the present invention of 1120um can by regulating length and then the adjusting hole gap varying aperture of support column 1, and method is simply effective, and can reach the object of aperture gradual change in conjunction with grille 2.
In order to better promote that osseous tissue is grown into, the present invention devises guide rod 3, when histiocyte crawls into metal tissue scaffold design outermost surface, can creep, be conducive to cell migration along guide rod 3, and then promotes that osseous tissue is grown into.Guide rod 3 can carry out adjustment and accept or reject according to the position putting into Cranial defect, retain and skeleton is grown into the consistent guide rod in direction, cell is creeped grow into more to meet human body natural's osseous tissue direction.
Claims (4)
1. 3D prints the medical porous metal tissue scaffold design in gradient aperture, and it is characterized in that, its entirety is hexahedron structure, be made up of assembly A, assembly B and assembly C close-packed arrays, assembly A array is in hexahedron structure outermost layer, and assembly B array is in secondary skin, and assembly C array is in innermost layer; Assembly A, assembly B, assembly C are hexahedron frame structure, and the aperture of assembly A is greater than the aperture of assembly B, and the aperture of assembly B is greater than the aperture of assembly C.
2. a kind of 3D as claimed in claim 1 prints the medical porous metal tissue scaffold design in gradient aperture, it is characterized in that, described assembly C is made up of support column (1) and guide rod (3), many support columns (1) connect and compose the arris of hexahedron frame structure, guide rod (3) is positioned at the line of centres in every relative two faces of hexahedron frame structure, and the guide rod (3) of adjacent component is connected to each other; Assembly A and assembly B is formed by support column (1), guide rod (3) and grille (2), grille (2) is positioned at the diagonal positions of hexahedron frame structure each, and in assembly B, the quantity of grille (2) is less than the quantity of grille (2) in assembly A.
3. a kind of 3D as claimed in claim 2 prints the medical porous metal tissue scaffold design in gradient aperture, and it is characterized in that, in described assembly B, the quantity of grille (2) is the half of the quantity of grille (2) in assembly A.
4. a kind of 3D as claimed in claim 2 prints the medical porous metal tissue scaffold design in gradient aperture, it is characterized in that, in described assembly A, hexahedron frame structure each is provided with two grilles (2), and in assembly B, hexahedron frame structure each is only established a grille (2).
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| CN105919696A (en) * | 2016-05-04 | 2016-09-07 | 宁波傲骨生物科技有限公司 | Preparation method of bionic artificial bone scaffold having mechanical gradient |
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| CN107198597A (en) * | 2016-03-18 | 2017-09-26 | 重庆润泽医药有限公司 | A kind of tibia support implant |
| CN107198596A (en) * | 2016-03-18 | 2017-09-26 | 重庆润泽医药有限公司 | A kind of acetabular cup |
| CN107198600A (en) * | 2016-03-18 | 2017-09-26 | 重庆润泽医药有限公司 | A kind of interbody spinal implant |
| CN107198599A (en) * | 2016-03-18 | 2017-09-26 | 重庆润泽医药有限公司 | A kind of shin bone stem implant |
| CN107260369A (en) * | 2017-06-15 | 2017-10-20 | 西安交通大学 | It is a kind of to be used for the personalized biological type cushion block of Cranial defect in total knee arthroplasty |
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| CN107647943A (en) * | 2017-11-02 | 2018-02-02 | 广州华钛三维材料制造有限公司 | A kind of metal bone trabecula and the skeleton implant for including the metal bone trabecula |
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