CN105232659A - Traditional Chinese medicine composition capable of soothing liver and strengthening spleen and preparing method thereof - Google Patents
Traditional Chinese medicine composition capable of soothing liver and strengthening spleen and preparing method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition capable of soothing liver and strengthening spleen and a preparing method thereof. The traditional Chinese medicine composition is characterized by being prepared from 60-200 parts of vinegar processed radix bupleuri, 100-200 parts of poria cocos, 200-400 parts of astragalus membranaceus, 60-200 parts of angelica sinensis, 80-200 parts of radix paeoniae alba, 100-220 parts of roasted rhizoma atractylodis macrocephalae, 100-180 parts of cortex albiziae, 100-180 parts of glossy privet fruit, 80-180 parts of polygala tenuifolia and 60-150 parts of rhodiola rosea. The invention further discloses the preparing method. The traditional Chinese medicine composition can soothe liver and strengthen spleen, replenish qi and nourish blood, and relieve fatigue and soothe the nerves.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition and preparation method thereof and detection method, particularly a kind of soothing liver and strengthening spleen Chinese medicine composition and preparation method thereof and detection method.
Background technology
Along with the development of modern society, work and the life stress of people strengthen day by day, and medicine and the food therefore with soothing liver and strengthening spleen function are more and more subject to people's attention and favor.At present, soothing liver and strengthening spleen drug variety is various, but curative effect is unsatisfactory, and most medicine needs to take the longer time, could slightly curative effect.
It is little that China's Chinese medicine has side effect, the feature that conditioning functions is outstanding, effectively can improve the problems such as stagnation of liver-QI.
Summary of the invention
The object of the present invention is to provide a kind of soothing liver and strengthening spleen Chinese medicine composition, another object of the present invention is the preparation method providing this Chinese medicine composition.
The present invention seeks to be achieved through the following technical solutions:
The crude drug of this Chinese medicine composition and weight portion are: Radix Bupleuri (processed with vinegar) 60-200 part, Poria 100-200 part, Radix Astragali 200-400 part, Radix Angelicae Sinensis 60-200 part, Radix Paeoniae Alba 80-200 part, Rhizoma Atractylodis Macrocephalae (parched) 100-220 part, Cortex Albiziae 100-180 part, Fructus Ligustri Lucidi 100-180 part, Radix Polygalae 80-180 part, Radix Rhodiolae 60-150 part.
Technical solution of the present invention can be:
The crude drug of this Chinese medicine composition and weight portion are: Radix Bupleuri (processed with vinegar) 80-160 part, Poria 120-180 part, Radix Astragali 220-380 part, Radix Angelicae Sinensis 80-160 part, Radix Paeoniae Alba 100-180 part, Rhizoma Atractylodis Macrocephalae (parched) 120-200 part, Cortex Albiziae 120-170 part, Fructus Ligustri Lucidi 120-170 part, Radix Polygalae 100-160 part, Radix Rhodiolae 80-120 part.
Technical solution of the present invention is preferably:
The crude drug of this Chinese medicine composition and weight portion are: Radix Bupleuri (processed with vinegar) 100 parts, 150 parts, Poria, the Radix Astragali 300 parts, Radix Angelicae Sinensis 100 parts, the Radix Paeoniae Alba 150 parts, Rhizoma Atractylodis Macrocephalae (parched) 150 parts, Cortex Albiziae 150 parts, Fructus Ligustri Lucidi 150 parts, Radix Polygalae 120 parts, Radix Rhodiolae 100 parts.
Technical solution of the present invention can also be:
The crude drug of this Chinese medicine composition and weight portion are: Radix Bupleuri (processed with vinegar) 90 parts, 130 parts, Poria, the Radix Astragali 230 parts, Radix Angelicae Sinensis 90 parts, the Radix Paeoniae Alba 110 parts, Rhizoma Atractylodis Macrocephalae (parched) 140 parts, Cortex Albiziae 130 parts, Fructus Ligustri Lucidi 120 parts, Radix Polygalae 130 parts, Radix Rhodiolae 90 parts.
Technical solution of the present invention can also be:
The crude drug of this Chinese medicine composition and weight portion are: Radix Bupleuri (processed with vinegar) 150 parts, 150 parts, Poria, the Radix Astragali 360 parts, Radix Angelicae Sinensis 120 parts, the Radix Paeoniae Alba 160 parts, Rhizoma Atractylodis Macrocephalae (parched) 160 parts, Cortex Albiziae 140 parts, Fructus Ligustri Lucidi 160 parts, Radix Polygalae 150 parts, Radix Rhodiolae 110 parts.
Chinese medicine composition of the present invention, its dosage form is the oral formulations such as capsule, granule, tablet, pill, powder.
The preparation method of Chinese medicine composition of the present invention is: all flavour of a drug decoct with water, and filters, concentrated, dry, adds right amount of auxiliary materials, mixing, subpackage.
The preparation method of Chinese medicine composition of the present invention is preferably: all flavour of a drug decoct with water 2 times, for the first time 60min, the 2nd 30min, filters, concentrated, dry, adds right amount of auxiliary materials, mixing, granulation, subpackage.
The preparation method of Chinese medicine composition of the present invention can be: all flavour of a drug decoct with water 2 times, for the first time 60min, the 2nd 30min, filters, concentrated, spraying dry, subpackage.
The preparation method of Chinese medicine composition of the present invention can also be: all flavour of a drug decoct with water, and filters, and concentrated, add ethanol, precipitate with ethanol, supernatant flings to ethanol, concentrated, adds right amount of auxiliary materials, dry, and mixing is granulated, subpackage.
The card that formula of the present invention cures mainly is caused by stagnation of liver-QI, and Shuganjianpi Formula is hepatic depression and blood deficiency, the card of dysfunction of the spleen in transportation and establishing.Liver is the viscus of storing blood, and property happiness tune reaches and main catharsis, body the moon sun.If seven emotions pent-up, liver can be made to lose bar and reach, irritability is not defeated, and emotion irritability rises thereupon demonstrate,proving.Cloudy blood secretly consumes, or the source of vital function is not enough, and liver body loses supports, and insomnia and dreamful sleep all can be made to rise thereupon demonstrate,proving.Body tiredness is tired, is the unable event of insufficiency of the spleen transporting.Now dispersing the stagnated live-QI to relieve the stagnation of QI, benefiting vital QI and blood also can be general.The existing Radix Bupleuri (processed with vinegar) dispersing the stagnated live-QI to relieve the stagnation of QI of we, has again Radix Angelicae Sinensis, Radix Paeoniae Alba nourishing blood to suppress the hyperactive liver.Especially the fragrance of Radix Angelicae Sinensis can circulation of qi promoting, and sweet in the mouth can emergency, the especially key medicine of hepatic depression and blood deficiency.The Rhizoma Atractylodis Macrocephalae, Poria spleen invigorating dehumidifying, transporting is had the right, and QI and blood is active, the Radix Astragali and Rhizoma Atractylodis Macrocephalae compatibility, can invigoration spleen qi, with Radix Angelicae Sinensis compatibility, can qi-supplementing, blood-engendering.Cortex Albiziae, Radix Polygalae, mind tranquilizing and the heart calming resolving depression.Fructus Ligustri Lucidi, liver and kidney tonifying.Radix Rhodiolae, strengthening healthy qi, benefiting qi and nourishing blood, modern pharmacological research shows to have resisting fatigue, antioxidation.The five tastes on this, though make it product for assistant, have the merit supported and assist in.Compatibility like this, liver spleen is also controlled, and QI and blood is taken into account, and comprehensively, medication is thoughtful in legislation.
Chinese medicine composition of the present invention can soothing liver and strengthening spleen, and benefiting qi and nourishing blood, calms the nerves except weary, and for stagnation of liver-QI with deficiency of the spleen, insufficiency of vital energy and blood, and dedicate one's life to tiredness is tired, insomnia and dreamful sleep, emotion irritability person.Clinical experiment shows to improve Be very effective.
Detailed description of the invention
Following examples for illustration of the present invention, but are not used for limiting the scope of the invention.
Embodiment 1
1, prescription:
Radix Bupleuri (processed with vinegar) 100g, Poria 150g, Radix Astragali 300g, Radix Angelicae Sinensis 100g, Radix Paeoniae Alba 150g, Rhizoma Atractylodis Macrocephalae (parched) 150g, Cortex Albiziae 150g, Fructus Ligustri Lucidi 150g, Radix Polygalae 120g, Radix Rhodiolae 100g.
2. method for making:
Whole flavour of a drug decoct with water 2 times, for the first time 60min, the 2nd 30min, and filtration is concentrated, dry, adds right amount of auxiliary materials, mixing, and granulation divides encapsulated, to obtain final product.
Embodiment 2
1, prescription:
Radix Bupleuri (processed with vinegar) 90g, Poria 130g, Radix Astragali 230g, Radix Angelicae Sinensis 90g, Radix Paeoniae Alba 110g, Rhizoma Atractylodis Macrocephalae (parched) 140g, Cortex Albiziae 130g, Fructus Ligustri Lucidi 120g, Radix Polygalae 130g, Radix Rhodiolae 90g.
2. method for making:
Whole flavour of a drug decoct with water 2 times, for the first time 60min, the 2nd 30min, filter, and concentrated, spraying dry, subpackage, to obtain final product.
Embodiment 3
1, prescription:
Radix Bupleuri (processed with vinegar) 150g, Poria 150g, Radix Astragali 360g, Radix Angelicae Sinensis 120g, Radix Paeoniae Alba 160g, Rhizoma Atractylodis Macrocephalae (parched) 160g, Cortex Albiziae 140g, Fructus Ligustri Lucidi 160g, Radix Polygalae 150g, Radix Rhodiolae 110g.
2. method for making:
Whole flavour of a drug decoct with water, and filter, and concentrated, add ethanol, precipitate with ethanol, supernatant flings to ethanol, concentrated, add right amount of auxiliary materials, dry, mixing, and granulate, subpackage, to obtain final product.
Embodiment 4
1, prescription:
Radix Bupleuri (processed with vinegar) 100g, Poria 150g, Radix Astragali 300g, Radix Angelicae Sinensis 100g, Radix Paeoniae Alba 150g, Rhizoma Atractylodis Macrocephalae (parched) 150g, Cortex Albiziae 150g, Fructus Ligustri Lucidi 150g, Radix Polygalae 120g, Radix Rhodiolae 100g.
2. method for making:
Whole flavour of a drug decoct with water 2 times, filter, and concentrated, add ethanol to 60%, precipitate with ethanol, supernatant flings to ethanol, concentrated, add right amount of auxiliary materials, dry, mixing, and granulate, subpackage, to obtain final product.
Embodiment 5: soothing liver and strengthening spleen clinical research
1.1 test methods: multicenter, random, double blinding, placebo controlled clinical trial, total sample size is 118 examples, treatment group 59 example, matched group 59 example.Group technology: research adopts treatment group to contrast with between group between matched group.
1.2, case selection
1.2.1 diagnosis and staging scale: with reference to NCCN breast carcinoma clinical practice guideline.
1.2.2 inclusive criteria:
The 2.1 women with breast cancer out-patient treatment patients having a clear and definite pathological diagnosis
After 2.2 mammary cancer radical operation excisions within 5 years, terminate radiotherapy or chemotherapy more than 1 month
2.3 confirm without tumor recurrence or transfer through clinical and iconography.
2.4ECOG marks as 0-2 divides
1.3 administrated method
Chinese drug-treated group: use sample prepared by the method for embodiment 1, morning and evening every day is each once, each one bag (4g), warm boiled water.The treatment surrounding course for the treatment of.
Matched group: placebo granulation, morning and evening every day is each once, each one bag, warm boiled water.The treatment surrounding course for the treatment of.
2 result of the tests:
2.1 baseline characteristic
Baseline characteristic main contents are age of patient, education degree, marital status, operating time, histological type, clinical scale, Therapeutic Method.Because 3 routine object of study do not include statistical analysis in, we carry out baseline characteristic analysis to 115 routine patients.In Baseline Data, measurement data adopts two sample t-test, and classification and ranked data adopt X 2 test.
2.2 test cards: evaluation table
2.2 result
A table 2 liang group tcm symptom scoring is compared
Result of the test shows, when treating 4 weeks, treatment group comparatively matched group is improved obviously, concrete statistical significance (P < 0.05).Illustrate that Chinese drug-treated group can treat the card of the stagnation of liver-QI with deficiency of the spleen of patient with breast cancer.
Embodiment 6: safety evaluatio
According to " new Chinese medicine guideline of clinical investigations ", originally study and define safety evaluatio project to comprise: routine blood test, routine urinalysis, just routine, hepatic and renal function, electrocardiogram, to evaluate the function of important organ and the records of adverse events such as the heart, liver, kidney, peripheral hemogram.Adverse events is defined as contingent any unexpected adverse reaction over the course for the treatment of, but itself and medication there is no inevitable cause effect relation.Serious adverse events is defined as and refers to and the event that dead, need be in hospital diagnosis and treatment, life-threatening etc. are associated.
Clinical scale is carried out to Liver and kidney function, electrocardiogram, defecation result, as normal, abnormal but without clinical meaning, exception and have clinical meaning, do not look into, adopt X 2 test, employing rank test during frequency < 5.Display: baseline and 4 weeks time, treatment group and matched group security inspection no difference of science of statistics (P > 0.05).
Claims (10)
1. a soothing liver and strengthening spleen Chinese medicine composition, it is characterized in that crude drug and the weight portion of this Chinese medicine composition are: Radix Bupleuri (processed with vinegar) 60-200 part, Poria 100-200 part, Radix Astragali 200-400 part, Radix Angelicae Sinensis 60-200 part, Radix Paeoniae Alba 80-200 part, Rhizoma Atractylodis Macrocephalae (parched) 100-220 part, Cortex Albiziae 100-180 part, Fructus Ligustri Lucidi 100-180 part, Radix Polygalae 80-180 part, Radix Rhodiolae 60-150 part.
2. Chinese medicine composition as claimed in claim 1, it is characterized in that crude drug and the weight portion of this Chinese medicine composition are: Radix Bupleuri (processed with vinegar) 80-160 part, Poria 120-180 part, Radix Astragali 220-380 part, Radix Angelicae Sinensis 80-160 part, Radix Paeoniae Alba 100-180 part, Rhizoma Atractylodis Macrocephalae (parched) 120-200 part, Cortex Albiziae 120-170 part, Fructus Ligustri Lucidi 120-170 part, Radix Polygalae 100-160 part, Radix Rhodiolae 80-120 part.
3. Chinese medicine composition as claimed in claim 2, it is characterized in that crude drug and the weight portion of this Chinese medicine composition are: Radix Bupleuri (processed with vinegar) 100 parts, 150 parts, Poria, the Radix Astragali 300 parts, Radix Angelicae Sinensis 100 parts, the Radix Paeoniae Alba 150 parts, Rhizoma Atractylodis Macrocephalae (parched) 150 parts, Cortex Albiziae 150 parts, Fructus Ligustri Lucidi 150 parts, Radix Polygalae 120 parts, Radix Rhodiolae 100 parts.
4. Chinese medicine composition as claimed in claim 2, it is characterized in that crude drug and the weight portion of this Chinese medicine composition are: Radix Bupleuri (processed with vinegar) 90 parts, 130 parts, Poria, the Radix Astragali 230 parts, Radix Angelicae Sinensis 90 parts, the Radix Paeoniae Alba 110 parts, Rhizoma Atractylodis Macrocephalae (parched) 140 parts, Cortex Albiziae 130 parts, Fructus Ligustri Lucidi 120 parts, Radix Polygalae 130 parts, Radix Rhodiolae 90 parts.
5. Chinese medicine composition as claimed in claim 2, it is characterized in that crude drug and the weight portion of this Chinese medicine composition are: Radix Bupleuri (processed with vinegar) 150 parts, 150 parts, Poria, the Radix Astragali 360 parts, Radix Angelicae Sinensis 120 parts, the Radix Paeoniae Alba 160 parts, Rhizoma Atractylodis Macrocephalae (parched) 160 parts, Cortex Albiziae 140 parts, Fructus Ligustri Lucidi 160 parts, Radix Polygalae 150 parts, Radix Rhodiolae 110 parts.
6. the Chinese medicine composition as described in as arbitrary in claim 1 to 5, it is characterized in that, its dosage form is the oral formulations such as capsule, granule, tablet, pill, powder.
7. the preparation method of the Chinese medicine composition as described in as arbitrary in claim 1 to 5, is characterized in that the method is: all flavour of a drug decoct with water, and filters, concentrated, dry, adds right amount of auxiliary materials, mixing, subpackage.
8. the preparation method of Chinese medicine composition as claimed in claim 7, is characterized in that the method is: all flavour of a drug decoct with water 2 times, for the first time 60min, the 2nd 30min, filters, concentrated, dry, adds right amount of auxiliary materials, mixing, granulation, subpackage.
9. the preparation method of the Chinese medicine composition as described in as arbitrary in claim 1 to 5, is characterized in that the method is: all flavour of a drug decoct with water 2 times, first time 60min, the 2nd 30min, filter, concentrated, spraying dry, subpackage.
10. the preparation method of the Chinese medicine composition as described in as arbitrary in claim 1 to 5, is characterized in that the method is: all flavour of a drug decoct with water, and filters, and concentrated, add ethanol, precipitate with ethanol, supernatant flings to ethanol, concentrated, adds right amount of auxiliary materials, dry, and mixing is granulated, subpackage.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101961190A (en) * | 2010-10-20 | 2011-02-02 | 刘爱霞 | Drug pillow for insomnia recovery |
| CN103736037A (en) * | 2014-01-28 | 2014-04-23 | 张怀胜 | Medicine for treating chronic fatigue syndrome and preparation method thereof |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101961190A (en) * | 2010-10-20 | 2011-02-02 | 刘爱霞 | Drug pillow for insomnia recovery |
| CN103736037A (en) * | 2014-01-28 | 2014-04-23 | 张怀胜 | Medicine for treating chronic fatigue syndrome and preparation method thereof |
Non-Patent Citations (1)
| Title |
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| 马红侠: "逍遥散新用", 《新中医》 * |
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