CN105214205A - A kind of intranasal administration plug of gastric heat epistaxis - Google Patents
A kind of intranasal administration plug of gastric heat epistaxis Download PDFInfo
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Abstract
The invention discloses a kind of intranasal administration plug of gastric heat epistaxis, comprise base, handle, cork and seal cover, wherein, be provided with boss between cork and handle, the upper end of cork is provided with styptic cotton, and lower end and the base of cork are adhesively fixed, seal cover and base are fastened and connected and are coated in seal cover by cork, the middle part of cork is provided with medicine bag, is provided with some spray medicine passages, is adhesively fixed between boss and handle between medicine bag and styptic cotton, between medicine bag and the wall of cork; Medicine bag is built with the Chinese medicine composition of powdery, the component of described Chinese medicine composition is: Rhizoma Coptidis, Phyllostachys congesta eat, each 45-60g of Gypsum Fibrosum, Fructus Forsythiae, Fructus Chaenomelis, Fructus Evodiae, Radix Ginseng, each 30-45g of Pericarpium Citri Reticulatae, Testa arachidis hypogaeae, Folium Artemisiae Argyi, Ophicalcitum, Lignum Dalbergiae Odoriferae, catechu, humus flava usta, Rhizoma Dioscoreae Bulbiferae, each 10-20g of Herba Agrimoniae, Radix Glycyrrhizae 10-15g.Structure of the present invention is simple, easy to use, and drug ratio composition is simple, and anthemorrhagic speed is fast, Shorten the Treatment Process.
Description
Technical field
The present invention relates to medical art, particularly relate to a kind of intranasal administration plug of gastric heat epistaxis.
Background technology
Epistaxis, refers to epistaxis.The origin cause of formation of epistaxis, lung, stomach, liver,spleen,kidney are uncomfortable, all can bring out this card, burning hot Sheng partially, the absurd row of forcing blood, so that blood oozing from the body openings or subcuta neous tissue is cleaned the street, and flows out form epistaxis from nostril." Ling Shu Miraculous Pivot or Divine Axis all kinds of diseases and ailments begin raw ": " injury of YANG-collateral leading to outwards bleeding, the excessive then epistaxis of blood." but the card name of " epistaxis ", then see Thousand Golden Prescriptions volume six." Standards of Diagnosis and Treatment miscellaneous diseases ": " nosebleed person, due to wound wind and cold heat-damp in summer, flowing meridians, gush and let out the person of causing in clearing heat in QI system road, all outer institute because of.Long-pending excessive anger impairing the liver, long-pending melancholy impairing the lung, tired anxiety impairing the spleen, mental confusion are impairment of the kidney, overwhelming joy impairing heart, all active blood, with person caused by gas overflow, in belonging to institute because of.Drinking too much, eats that to process Bo hot, or the pendant vehicle and horse trauma person of causing, in all non-, non-exopathogenic factor also." epistaxis, lack of appetite body is tired, and red, the person of being in a trance, and should Radix Rubiae ball, Terra Flava Usta soup treat; The many persons of epistaxis amount, should Flos Imperatae soup.External treatment can fall apart with ten and fill in noses, the nasal insufflation of Fructus Gardeniae charcoal, and the methods such as Alumen end nasal insufflation, available warm water soaks sufficient method again.Deficiency of YIN epistaxis person, should heavy dose of Radix Rehmanniae decoction.The etiology and pathogenesis of epistaxis can be divided into void, real two large classes.Excess syndrome person, how because of lung, stomach, liver be intimately main, scorching in bad temper, follow the venation through upper steaming nose and be nosebleed; Deficiency syndrome person, is more common in the hepatic and renal YIN deficiency, in asthenic fire more, and venation of burning and cause nosebleed, or because of deficiency-weakness of spleen-QI, QI failing to control blood and be nosebleed.In Coryza Treated by Syndrome Differentiation, the emergency of the epistaxis Main Basis state of an illness, the number of amount of bleeding, the depth of color, and General Symptoms carries out Coryza Treated by Syndrome Differentiation.Excess syndrome epistaxis, based on resolving heat and reducing pathogenic fire in treatment; If deficiency syndrome epistaxis, hepatic and renal YIN deficiency person, should nourishing YIN to lower pathogenic fire be main; If deficiency of spleen-QI weak person, then hemostasis by invigorating the spleen is answered to stop blooding.
The typing of epistaxis as:
1, lung meridian excessive heat type.Affection due to external wind and heat or scorching heresy, attacking the lung first, pathogenic heat follow through, upper heap soil or fertilizer over and around the roots nose key, thermal burn venation, abnormal circulation of blood, overflows in nose, therefore is epistaxis." Waike Zhengzong, Orthodox Manual of External Diseases " is rolled up four and is said: " bleeding in the nose is lung meridian hyperactivity of fire, the absurd row of forcing blood, and goes out from nose key." 2, intense stomach-heat type.Stomach is through have accumulated heat, or because of crapulence spirits, surfeit is pungent dry, so that stomach excessive heat, burns, follow through upper inflammation in burning hot, and yang collaterals in damage nose, blood gushes with heat, and absurd row outside arteries and veins, and is epistaxis." Longevity and Life Preservation " is rolled up four and is said: " epistaxis person, bleeding in the nose also, boil strongly fragrant by positive heat, activates stomach warp, strong in stomach-fire, then the absurd row of blood, therefore nosebleed also." " Sanyin Ji Yi Bingzheng Fang Lun " roll up nine and also say: " patient's drinking too much, and eat and process the hot food of Bo five, move in blood, blood overflows with gas, sends out as epistaxis, name alcoholic epitaxis." 3, liver-fire upward reversal.Feelings will is unsuccessful, depression of liver-QI, Yu Huahuo of a specified duration, or rage impairing the liver, liver-fire superinverse, and blood moves with fire, and steam and compel nose key, venation is impaired, and blood is excessive, sends out as epistaxis." Yangke Xinde Ji, Experience Gained in Treating External Diseases " is said: " have because of damaged by excess of seven emotions, interior its blood dynamic, causes with gas overflow." 4, liver-kidney yin deficiency.Excess of sexual intercourse, consume be impairment of the kidney essence or prolonged illness impairment of YIN, deficiency of the liver and kindey, the kidney failing to nourish the liver, liver can not store blood, hyperactivity of deficient fire, blood ascension, overflows in clear key, and is epistaxis." demonstrate,proving because arteries and veins is controlled " volume two is said: " or impairment of the kidney due to indulgence in sexual activities, cloudy insufficiency of essence, water generating fire, or angry impairing the liver, liver-fire movability, cloudy blood rises with fire, and bloody stool during menstruation is absurd more, then the disease of epistaxis with internal injury is done." Jing-Yue Complete Works volume 30 also says: " and though epistaxis is many by fire, and only in deficiency of YIN person for outstanding many, just to strain impairment of YIN, then water failing to restrain blazing fire, the blood that the most active punching appoints the moon to divide." 5, failure of the spleen to keep the blood flowing within the vessels type (deficiency-weakness of spleen-QI).Obstinate disease, melancholy,anxiety and overstrain, eating and drinking without temperance, damage temper, deficiency-weakness of spleen-QI, system blood mistake department, QI failing to control blood, escape of blood from meridians, depart from sering, seepage in nose, and causes epistaxis.The patient of failure of the spleen to keep the blood flowing within the vessels type, epistaxis oozes, and color is light red, and amount more or less.Lustreless complexion, diet reduces, spiritlessness and sparing of words.Pale tongue with thin fur, moderate pulse is weak.
For epistaxis caused by gastric heat, because of crapulence spirits, surfeit is pungent dry, so that stomach excessive heat, burns, follow through upper inflammation in burning hot, and yang collaterals in damage nose, blood gushes with heat, and absurd row outside arteries and veins, and is epistaxis." Longevity and Life Preservation " is rolled up four and is said: " epistaxis person, bleeding in the nose also, boil strongly fragrant by positive heat, activates stomach warp, strong in stomach-fire, then the absurd row of blood, therefore nosebleed also." " Sanyin Ji Yi Bingzheng Fang Lun " roll up nine and also say: " patient's drinking too much, and eat and process the hot food of Bo five, move in blood, blood overflows with gas, sends out as epistaxis, name alcoholic epitaxis." Patients of Nasal Hemorrhage of intense stomach-heat type, bleeding in the nose, amount is many, and color is scarlet or dark red, and intranasal is dry, xerostomia halitosis, excessive thirst taking fluids profusely, constipation due to dry stool, oliguria with reddish urine.Red tongue, yellow fur is thick dry, full and large pulse and counting.The treatment of the patient of this type, should clearing stomach pathogenic fire reducing, cooling blood for hemostasis.Traditional treatment prescription as: prescription added and subtracted by xijiao Dihuang Tang (Sun Simiao Prescriptions Worth Thousand Gold for Emergencies): Radix Rehmanniae 15 grams, Radix Paeoniae Rubra 15 grams, Cortex Moutan 15 grams, the Rhizoma Anemarrhenae 15 grams, Gypsum Fibrosum 30 grams, Cornu Bubali 60 grams, 6 grams, Radix Glycyrrhizae.Be decocted in water for oral dose.Rhizoma Imperatae 15 grams, Cacumen Platycladi 15 grams, Herba Ecliptae 15 grams should be added clinically.Constipation person, adds Radix Et Rhizoma Rhei 10 grams (under rear), Semen Trichosanthis 15 grams.
In prior art, for the medicine of epistaxis caused by gastric heat, as Chinese patent application 201310380818.6 discloses intense stomach-heat type Patients of Nasal Hemorrhage Chinese medicine composition, active component: Rhizoma Phragmitis 30-45g, Radix Scrophulariae 20-30g, Semen Cassiae 20-30g, Folium Isatidis 20-30g, Radix Paeoniae Rubra 10-20g, Herba Patriniae 10-20g, Herba Schizonepetae 10-20g, Pericarpium Citri Reticulatae 10-20g, Herba Menthae 10-20g, Pericarpium Papaveris 10-20g, Semen phaseoli radiati 10-20g, Folium Bambusae 10-20g, Cacumen Platycladi 10-20g, Radix Asparagi 10-20g.Although be decocted in water for oral dose for regulating internal organs, be conducive to removing the cause of disease, the course for the treatment of is long, takes effect slow.For because of liver-fire superinverse bleeder, the course for the treatment of, length can cause the problems such as its weak constitution, debility, and therefore, quick-acting haemostatic powder, Shorten the Treatment Process is solution.
In view of this technical problem, need to occur that a kind of structure is simple, easy to use, drug ratio composition is simple, and anthemorrhagic speed is fast, the intranasal administration plug of a kind of gastric heat epistaxis of Shorten the Treatment Process.
Summary of the invention
Technical problem to be solved by this invention is, provides a kind of structure simple, easy to use, and drug ratio composition is simple, and anthemorrhagic speed is fast, the intranasal administration plug of a kind of gastric heat epistaxis of Shorten the Treatment Process.
For solving the problems of the technologies described above, the invention provides a kind of intranasal administration plug of gastric heat epistaxis, comprise base, handle, cork and seal cover, wherein, boss is provided with between cork and handle, the upper end of cork is provided with styptic cotton, lower end and the base of cork are adhesively fixed, seal cover and base are fastened and connected and are coated in seal cover by cork, the middle part of cork is provided with medicine bag, be provided with some spray medicine passages between medicine bag and styptic cotton, between medicine bag and the wall of cork, be adhesively fixed between boss and handle; Medicine bag is built with the Chinese medicine composition of powdery, the component of described Chinese medicine composition is: Rhizoma Coptidis, Phyllostachys congesta eat, each 45-60g of Gypsum Fibrosum, Fructus Forsythiae, Fructus Chaenomelis, Fructus Evodiae, Radix Ginseng, each 30-45g of Pericarpium Citri Reticulatae, Testa arachidis hypogaeae, Folium Artemisiae Argyi, Ophicalcitum, Lignum Dalbergiae Odoriferae, catechu, humus flava usta, Rhizoma Dioscoreae Bulbiferae, each 10-20g of Herba Agrimoniae, Radix Glycyrrhizae 10-15g.
Or, the component of described Chinese medicine composition is: Rhizoma Coptidis, Phyllostachys congesta eat, each 45-55g of Gypsum Fibrosum, Fructus Forsythiae, Fructus Chaenomelis, Fructus Evodiae, Radix Ginseng, each 30-40g of Pericarpium Citri Reticulatae, Testa arachidis hypogaeae, Folium Artemisiae Argyi, Ophicalcitum, Lignum Dalbergiae Odoriferae, catechu, humus flava usta, Rhizoma Dioscoreae Bulbiferae, each 10-15g of Herba Agrimoniae, Radix Glycyrrhizae 10-12g.
Or, the component of described Chinese medicine composition is: Rhizoma Coptidis, Phyllostachys congesta eat, each 50-55g of Gypsum Fibrosum, Fructus Forsythiae, Fructus Chaenomelis, Fructus Evodiae, Radix Ginseng, each 35-40g of Pericarpium Citri Reticulatae, Testa arachidis hypogaeae, Folium Artemisiae Argyi, Ophicalcitum, Lignum Dalbergiae Odoriferae, catechu, humus flava usta, Rhizoma Dioscoreae Bulbiferae, each 15-20g of Herba Agrimoniae, Radix Glycyrrhizae 12-15g.
The manufacture method of the intranasal administration plug of gastric heat epistaxis of the present invention, wherein, step is as follows:
A, each component pulverized as 80-100 order size and be mixed, after being soaked in water 24 hours, adopting water extract method lixiviate three times, after three times lixiviating solution merges, add the starch of total lixiviating solution quality 1/30, steaming and decocting to after thick, dry medicated powder;
10-50 mesh sieve crossed by B, steps A gained medicated powder, and after sieve, gains obtain described important composition after ultra-vioket radiation sterilization 15S;
C, each medicine bag load 5-10g step B gained powder,
After D, base and handle are adhesively fixed, medicine bag outer wrap cotton cork, bottom cork, applying glue is bonding with base, and cork top embeds styptic cotton, and medicine bag, spray medicine passage are soft plastic product,
E, seal cover to fasten on base and are enclosed in seal cover by cork.
The relative molecular mass < 1000Mr of obtained medicated powder.
Advantage of the present invention, structure is simple, easy to use, drug ratio composition is simple, and anthemorrhagic speed is fast, Shorten the Treatment Process, be specially: Chinese medicine composition of the present invention, medicine Rhizoma Coptidis, Phyllostachys congesta are eaten with clearing stomach the turbid descending, eliminating stomach-fire be monarch drug to medical gypsum, Fructus Forsythiae, regulating the stomach and sending down the abnormal ascending QI to medicine Fructus Chaenomelis, Fructus Evodiae, QI invigorating stomach function regulating be ministerial drug to medicine Radix Ginseng, Pericarpium Citri Reticulatae; With the Testa arachidis hypogaeae of hemostasis, Folium Artemisiae Argyi, Ophicalcitum, Lignum Dalbergiae Odoriferae, catechu, humus flava usta, Rhizoma Dioscoreae Bulbiferae, Herba Agrimoniae for adjuvant drug; With Radix Glycyrrhizae for making medicine; The Chinese medicine composition of preparation adds starch and obtains medicated powder after flooding method refinement effective ingredient, and sterilization after sieve, loads medicine bag.When the present invention uses, pull up seal cover, cork is filled in nostril of bleeding, because of squeezing action when filling in, in the surface that medicated powder is ejected into cork along medicine bag or nostril, quick-acting haemostatic powder, greatly Shorten the Treatment Process time.
The present invention, by nasal mucosa administration.Nasal mucosa administration oneself be considered to one of administering mode that medicine can rapidly and efficiently absorb.Nasal mucosa cell has a lot of microvilli, therefore considerably increases the effective area of drug absorption, have abundant blood vessel and lymphatic vessel under mucosa cells, medicine is by directly entering body circulation after mucosal absorption.In addition, the metabolism of nasal cavity endoenzyme is far smaller than gastrointestinal tract, and therefore, nasal drug delivery system is subject to people's attention just day by day, comprises the research of peptide class and protein drug.And medicine absorbs from nasil district, the treatment for some central nervous system disease provides an effective route of administration.The surface area of mankind's bronchia mucosal is about 150 square centimeters, mucosa has a lot of microvilli, considerably increases the effective area of drug absorption, and the mucous layer of nasal cavity is very thin, and there is abundant blood vessel and lymphatic vessel under mucosa, medicine is easily absorbed by bronchia mucosal; In addition, the metabolism of nasal cavity endoenzyme is far smaller than gastrointestinal tract.Therefore, rapid by drug absorption after nasal-cavity administration, ideal bioavailability can be obtained.Directly can enter body circulation after medicine via intranasal application mucosal absorption, therefore, it is possible to avoid first pass effect and the gastrointestinal degraded of liver, improve the bioavailability of some drugs.Monarch drug of the present invention, ministerial drug are clearing stomach, the turbid descending medicine, and powdered medicaments sprays into nostril and entered blood circulation by Nasal Mucosa Absorption.Namely the present invention takes into account and effects a permanent cure while controlling table, insufficiency of the spleen from interior adjustment, and from outer hemostasis, treatment flow time at least shortens half.
Accompanying drawing illustrates:
Fig. 1 is structural representation of the present invention.
Reference numeral:
1, seal cover 2, cork 3, styptic cotton
4, medicine passage 5, medicine bag 6, base is sprayed
7, boss 8, handle
Detailed description of the invention
As shown in Figure 1, Fig. 1 is structural representation of the present invention.
The invention provides the intranasal administration plug of gastric heat epistaxis, comprise base 6, handle 8, cork 2 and seal cover 1, wherein, boss 7 is provided with between cork 2 and handle 8, the upper end of cork 7 is provided with styptic cotton 3, lower end and the base 6 of cork 7 are adhesively fixed, seal cover 1 and base 6 are fastened and connected and are coated in seal cover 1 by cork 2, the middle part of cork 7 is provided with medicine bag 5, be provided with some spray medicine passages 4 between medicine bag 5 and styptic cotton 3, between medicine bag 5 and the wall of cork 2, be adhesively fixed between boss 7 and handle 8; Medicine bag 5 is built with the Chinese medicine composition of powdery.
The component of described Chinese medicine composition is: Rhizoma Coptidis, Phyllostachys congesta eat, each 45-60g of Gypsum Fibrosum, Fructus Forsythiae, Fructus Chaenomelis, Fructus Evodiae, Radix Ginseng, each 30-45g of Pericarpium Citri Reticulatae, Testa arachidis hypogaeae, Folium Artemisiae Argyi, Ophicalcitum, Lignum Dalbergiae Odoriferae, catechu, humus flava usta, Rhizoma Dioscoreae Bulbiferae, each 10-20g of Herba Agrimoniae, Radix Glycyrrhizae 10-15g.
Or, the component of described Chinese medicine composition is: Rhizoma Coptidis, Phyllostachys congesta eat, each 45-55g of Gypsum Fibrosum, Fructus Forsythiae, Fructus Chaenomelis, Fructus Evodiae, Radix Ginseng, each 30-40g of Pericarpium Citri Reticulatae, Testa arachidis hypogaeae, Folium Artemisiae Argyi, Ophicalcitum, Lignum Dalbergiae Odoriferae, catechu, humus flava usta, Rhizoma Dioscoreae Bulbiferae, each 10-15g of Herba Agrimoniae, Radix Glycyrrhizae 10-12g.
Or, the component of described Chinese medicine composition is: Rhizoma Coptidis, Phyllostachys congesta eat, each 50-55g of Gypsum Fibrosum, Fructus Forsythiae, Fructus Chaenomelis, Fructus Evodiae, Radix Ginseng, each 35-40g of Pericarpium Citri Reticulatae, Testa arachidis hypogaeae, Folium Artemisiae Argyi, Ophicalcitum, Lignum Dalbergiae Odoriferae, catechu, humus flava usta, Rhizoma Dioscoreae Bulbiferae, each 15-20g of Herba Agrimoniae, Radix Glycyrrhizae 12-15g.
Example 1,
Zhao, eating and drinking too much at one meal, so that stomach excessive heat, burn in burning hot, follow through upper inflammation, and yang collaterals in damage nose, blood gushes with heat, and absurd row outside arteries and veins, and is epistaxis.The intranasal administration plug of the gastric heat epistaxis used, the component of the Chinese medicine composition loaded in medicine bag is: Rhizoma Coptidis, Phyllostachys congesta eat, each 60g of Gypsum Fibrosum, Fructus Forsythiae, Fructus Chaenomelis, Fructus Evodiae, Radix Ginseng, each 45g of Pericarpium Citri Reticulatae, Testa arachidis hypogaeae, Folium Artemisiae Argyi, Ophicalcitum, Lignum Dalbergiae Odoriferae, catechu, humus flava usta, Rhizoma Dioscoreae Bulbiferae, each 20g of Herba Agrimoniae, Radix Glycyrrhizae 15g.
A, each component pulverized as 80-100 order size and be mixed, after being soaked in water 24 hours, adopting water extract method lixiviate three times, after three times lixiviating solution merges, add the starch of total lixiviating solution quality 1/30, steaming and decocting to after thick, dry medicated powder;
10-50 mesh sieve crossed by B, steps A gained medicated powder, and after sieve, gains obtain described important composition after ultra-vioket radiation sterilization 15S;
C, each medicine bag load 5-10g step B gained powder,
After D, base and handle are adhesively fixed, medicine bag outer wrap cotton cork, bottom cork, applying glue is bonding with base, and cork top embeds styptic cotton, and medicine bag, spray medicine passage are soft plastic product,
E, seal cover to fasten on base and are enclosed in seal cover by cork.
The intranasal administration plug of gastric heat epistaxis is filled in nostril of bleeding, and 15 minutes blood only.After 2 hours, the intranasal administration plug of the gastric heat epistaxis more renewed.After this use the intranasal administration plug of a gastric heat epistaxis every day, each use 1 hour, after using 7 days continuously.Stop using.
Visit after three months, during this, again epistaxis does not occur.
Object lesson 2
Lee, strong in stomach-fire, then the absurd row of blood, bleeding in the nose, amount is many, and color is scarlet or dark red, and intranasal is dry, xerostomia halitosis, full and large pulse and counting.The intranasal administration plug of the gastric heat epistaxis used, the component of the Chinese medicine composition loaded in medicine bag is: Rhizoma Coptidis, Phyllostachys congesta eat, each 45g of Gypsum Fibrosum, Fructus Forsythiae, Fructus Chaenomelis, Fructus Evodiae, Radix Ginseng, each 30g of Pericarpium Citri Reticulatae, Testa arachidis hypogaeae, Folium Artemisiae Argyi, Ophicalcitum, Lignum Dalbergiae Odoriferae, catechu, humus flava usta, Rhizoma Dioscoreae Bulbiferae, each 15g of Herba Agrimoniae, Radix Glycyrrhizae 12g.
A, each component pulverized as 80-100 order size and be mixed, after being soaked in water 24 hours, adopting water extract method lixiviate three times, after three times lixiviating solution merges, add the starch of total lixiviating solution quality 1/30, steaming and decocting to after thick, dry medicated powder;
10-50 mesh sieve crossed by B, steps A gained medicated powder, and after sieve, gains obtain described important composition after ultra-vioket radiation sterilization 15S;
C, each medicine bag load 5-10g step B gained powder,
After D, base and handle are adhesively fixed, medicine bag outer wrap cotton cork, bottom cork, applying glue is bonding with base, and cork top embeds styptic cotton, and medicine bag, spray medicine passage are soft plastic product,
E, seal cover to fasten on base and are enclosed in seal cover by cork.
The intranasal administration plug of gastric heat epistaxis is filled in nostril of bleeding, and 15 minutes blood only.After 2 hours, the intranasal administration plug of the gastric heat epistaxis more renewed.After this use the intranasal administration plug of a gastric heat epistaxis every day, each use 1 hour, after using 4 days continuously.Stop using.
Visit after three months, during this, again epistaxis does not occur.
Object lesson 3
Pay certain, patient's drinking too much, moves in blood, and blood overflows with gas, constipation due to dry stool, oliguria with reddish urine, and send out as epistaxis, color is scarlet or dark red.The intranasal administration plug of the gastric heat epistaxis used, the component of the Chinese medicine composition loaded in medicine bag is: Rhizoma Coptidis, Phyllostachys congesta eat, each 50g of Gypsum Fibrosum, Fructus Forsythiae, Fructus Chaenomelis, Fructus Evodiae, Radix Ginseng, each 40g of Pericarpium Citri Reticulatae, Testa arachidis hypogaeae, Folium Artemisiae Argyi, Ophicalcitum, Lignum Dalbergiae Odoriferae, catechu, humus flava usta, Rhizoma Dioscoreae Bulbiferae, each 12g of Herba Agrimoniae, Radix Glycyrrhizae 10g.
A, each component pulverized as 80-100 order size and be mixed, after being soaked in water 24 hours, adopting water extract method lixiviate three times, after three times lixiviating solution merges, add the starch of total lixiviating solution quality 1/30, steaming and decocting to after thick, dry medicated powder;
10-50 mesh sieve crossed by B, steps A gained medicated powder, and after sieve, gains obtain described important composition after ultra-vioket radiation sterilization 15S;
C, each medicine bag load 5-10g step B gained powder,
After D, base and handle are adhesively fixed, medicine bag outer wrap cotton cork, bottom cork, applying glue is bonding with base, and cork top embeds styptic cotton, and medicine bag, spray medicine passage are soft plastic product,
E, seal cover to fasten on base and are enclosed in seal cover by cork.
The intranasal administration plug of gastric heat epistaxis is filled in nostril of bleeding, and 15 minutes blood only.After 2 hours, the intranasal administration plug of the gastric heat epistaxis more renewed.After this use the intranasal administration plug of a gastric heat epistaxis every day, each use 1 hour, after using 5 days continuously.Stop using.
Visit after three months, during this, again epistaxis does not occur.
Object lesson 4
Field, bleeding in the nose, amount is many, and intranasal is dry, xerostomia halitosis, excessive thirst taking fluids profusely, constipation due to dry stool, oliguria with reddish urine, red tongue, and yellow fur is thick dry, full and large pulse and counting.The intranasal administration plug of the gastric heat epistaxis used, the component of the Chinese medicine composition loaded in medicine bag is: Rhizoma Coptidis, Phyllostachys congesta eat, each 55g of Gypsum Fibrosum, Fructus Forsythiae, Fructus Chaenomelis, Fructus Evodiae, Radix Ginseng, each 35g of Pericarpium Citri Reticulatae, Testa arachidis hypogaeae, Folium Artemisiae Argyi, Ophicalcitum, Lignum Dalbergiae Odoriferae, catechu, humus flava usta, Rhizoma Dioscoreae Bulbiferae, each 18g of Herba Agrimoniae, Radix Glycyrrhizae 14g.
A, each component pulverized as 80-100 order size and be mixed, after being soaked in water 24 hours, adopting water extract method lixiviate three times, after three times lixiviating solution merges, add the starch of total lixiviating solution quality 1/30, steaming and decocting to after thick, dry medicated powder;
10-50 mesh sieve crossed by B, steps A gained medicated powder, and after sieve, gains obtain described important composition after ultra-vioket radiation sterilization 15S;
C, each medicine bag load 5-10g step B gained powder,
After D, base and handle are adhesively fixed, medicine bag outer wrap cotton cork, bottom cork, applying glue is bonding with base, and cork top embeds styptic cotton, and medicine bag, spray medicine passage are soft plastic product,
E, seal cover to fasten on base and are enclosed in seal cover by cork.
The intranasal administration plug of gastric heat epistaxis is filled in nostril of bleeding, and 15 minutes blood only.After 2 hours, the intranasal administration plug of the gastric heat epistaxis more renewed.After this use the intranasal administration plug of a gastric heat epistaxis every day, each use 1 hour, after using 6 days continuously.Stop using.
Visit after three months, during this, again epistaxis does not occur.
Experiment is compared:
Select rat 50, fill with food cayenne pepper, sweet food, within every 2 hours, once 40 as a child.Obtain gastric heat epistaxis rat model 40,40 epistaxis rats are divided into 4 groups at random:
The nasal insufflation of A group Fructus Gardeniae charcoal
The end nasal insufflation of B group Alumen
C group 201310380818.6 gained decoction perfusion 5ml
D group uses the medicinal powder spray nose of the embodiment of the present invention 1.For D group rat blood drawing test, after spray, half an hour, 1 hour, 1.5 hours, 2 hours draw blood respectively and measure blood drug level, and find that absorbance is that half an hour is best, absorption water molecules measured value is respectively 0.118 and 0.44min-1.
Therapeutic effect comparison sheet:
By above-mentioned list, can find, short treating period of the present invention, therapeutic effect is good.
Structure of the present invention is simple, easy to use, drug ratio composition is simple, anthemorrhagic speed is fast, and Shorten the Treatment Process, is specially: Chinese medicine composition of the present invention, medicine Rhizoma Coptidis, Phyllostachys congesta are eaten with clearing stomach the turbid descending, eliminating stomach-fire be monarch drug to medical gypsum, Fructus Forsythiae, regulating the stomach and sending down the abnormal ascending QI to medicine Fructus Chaenomelis, Fructus Evodiae, QI invigorating stomach function regulating be ministerial drug to medicine Radix Ginseng, Pericarpium Citri Reticulatae; With the Testa arachidis hypogaeae of hemostasis, Folium Artemisiae Argyi, Ophicalcitum, Lignum Dalbergiae Odoriferae, catechu, humus flava usta, Rhizoma Dioscoreae Bulbiferae, Herba Agrimoniae for adjuvant drug; With Radix Glycyrrhizae for making medicine; The Chinese medicine composition of preparation adds starch and obtains medicated powder after flooding method refinement effective ingredient, and sterilization after sieve, loads medicine bag.When the present invention uses, pull up seal cover, cork is filled in nostril of bleeding, because of squeezing action when filling in, in the surface that medicated powder is ejected into cork along medicine bag or nostril, quick-acting haemostatic powder, greatly Shorten the Treatment Process time.
The present invention, by nasal mucosa administration.Nasal mucosa administration oneself be considered to one of administering mode that medicine can rapidly and efficiently absorb.Nasal mucosa cell has a lot of microvilli, therefore considerably increases the effective area of drug absorption, have abundant blood vessel and lymphatic vessel under mucosa cells, medicine is by directly entering body circulation after mucosal absorption.In addition, the metabolism of nasal cavity endoenzyme is far smaller than gastrointestinal tract, and therefore, nasal drug delivery system is subject to people's attention just day by day, comprises the research of peptide class and protein drug.And medicine absorbs from nasil district, the treatment for some central nervous system disease provides an effective route of administration.The surface area of mankind's bronchia mucosal is about 150 square centimeters, mucosa has a lot of microvilli, considerably increases the effective area of drug absorption, and the mucous layer of nasal cavity is very thin, and there is abundant blood vessel and lymphatic vessel under mucosa, medicine is easily absorbed by bronchia mucosal; In addition, the metabolism of nasal cavity endoenzyme is far smaller than gastrointestinal tract.Therefore, rapid by drug absorption after nasal-cavity administration, ideal bioavailability can be obtained.Directly can enter body circulation after medicine via intranasal application mucosal absorption, therefore, it is possible to avoid first pass effect and the gastrointestinal degraded of liver, improve the bioavailability of some drugs.Monarch drug of the present invention, ministerial drug are clearing stomach, the turbid descending medicine, and powdered medicaments sprays into nostril and entered blood circulation by Nasal Mucosa Absorption.Namely the present invention takes into account and effects a permanent cure while controlling table, insufficiency of the spleen from interior adjustment, and from outer hemostasis, treatment flow time at least shortens half
The present invention adopts the intranasal administration plug form of gastric heat epistaxis to fill in nostril administration, and patient can complete voluntarily.Absorb rapidly.Nasal mucosa has numerous microvillis, greatly can increase the effective surface area of drug absorption, upper subcutaneously have abundant blood capillary, contributes to drug absorption.Avoid liver first-pass effect.Medicine directly enters human circulation after Nasal mucosa absorption, and trans-portal vein does not enter liver, without liver first-pass effect, thus improves its bioavailability.
Claims (4)
1. the intranasal administration plug of a gastric heat epistaxis, comprise base (6), handle (8), cork (2) and seal cover (1), it is characterized in that, boss (7) is provided with between cork (2) and handle (8), the upper end of cork (7) is provided with styptic cotton (3), lower end and the base (6) of cork (7) are adhesively fixed, seal cover (1) and base (6) are fastened and connected and are coated in seal cover (1) by cork (2), the middle part of cork (7) is provided with medicine bag (5), between medicine bag (5) and styptic cotton (3), some spray medicine passages (4) are provided with between the wall of medicine bag (5) and cork (2), be adhesively fixed between boss (7) and handle (8), medicine bag (5) is built with the Chinese medicine composition of powdery, the component of described Chinese medicine composition is: Rhizoma Coptidis, Phyllostachys congesta eat, each 45-60g of Gypsum Fibrosum, Fructus Forsythiae, Fructus Chaenomelis, Fructus Evodiae, Radix Ginseng, each 30-45g of Pericarpium Citri Reticulatae, Testa arachidis hypogaeae, Folium Artemisiae Argyi, Ophicalcitum, Lignum Dalbergiae Odoriferae, catechu, humus flava usta, Rhizoma Dioscoreae Bulbiferae, each 10-20g of Herba Agrimoniae, Radix Glycyrrhizae 10-15g.
2. the intranasal administration plug of gastric heat epistaxis according to claim 1, it is characterized in that, the component of described Chinese medicine composition is: Rhizoma Coptidis, Phyllostachys congesta eat, each 45-55g of Gypsum Fibrosum, Fructus Forsythiae, Fructus Chaenomelis, Fructus Evodiae, Radix Ginseng, each 30-40g of Pericarpium Citri Reticulatae, Testa arachidis hypogaeae, Folium Artemisiae Argyi, Ophicalcitum, Lignum Dalbergiae Odoriferae, catechu, humus flava usta, Rhizoma Dioscoreae Bulbiferae, each 10-15g of Herba Agrimoniae, Radix Glycyrrhizae 10-12g.
3. the intranasal administration plug of gastric heat epistaxis according to claim 1, it is characterized in that, the component of described Chinese medicine composition is: Rhizoma Coptidis, Phyllostachys congesta eat, each 50-55g of Gypsum Fibrosum, Fructus Forsythiae, Fructus Chaenomelis, Fructus Evodiae, Radix Ginseng, each 35-40g of Pericarpium Citri Reticulatae, Testa arachidis hypogaeae, Folium Artemisiae Argyi, Ophicalcitum, Lignum Dalbergiae Odoriferae, catechu, humus flava usta, Rhizoma Dioscoreae Bulbiferae, each 15-20g of Herba Agrimoniae, Radix Glycyrrhizae 12-15g.
4., according to the manufacture method of the intranasal administration plug of the arbitrary described gastric heat epistaxis of claim 1-3, it is characterized in that, step is as follows:
A, each component pulverized as 80-100 order size and be mixed, after being soaked in water 24 hours, adopting water extract method lixiviate three times, after three times lixiviating solution merges, add the starch of total lixiviating solution quality 1/30, steaming and decocting to after thick, dry medicated powder;
10-50 mesh sieve crossed by B, steps A gained medicated powder, and after sieve, gains obtain described important composition after ultra-vioket radiation sterilization 15S;
C, each medicine bag load 5-10g step B gained powder,
After D, base and handle are adhesively fixed, medicine bag outer wrap cotton cork, bottom cork, applying glue is bonding with base, and cork top embeds styptic cotton, and medicine bag, spray medicine passage are soft plastic product,
E, seal cover to fasten on base and are enclosed in seal cover by cork.
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| CN2208397Y (en) * | 1994-08-03 | 1995-09-27 | 耿泰山 | Convenient hemostatic embolism for nasal-cavity |
| CN2877588Y (en) * | 2006-02-16 | 2007-03-14 | 赵燕 | Nasal hemostat |
| CN103479905A (en) * | 2013-08-28 | 2014-01-01 | 严中明 | Chinese medicinal composition for stomach excessive heat type epistaxis patients |
| CN203662835U (en) * | 2014-01-10 | 2014-06-25 | 樊鹂 | Disposable cotton swab with haemostatic drugs |
| CN104206837A (en) * | 2014-08-16 | 2014-12-17 | 严中明 | Pig fattening additive |
| CN104740139A (en) * | 2012-01-05 | 2015-07-01 | 谢有珠 | Vegetative Chinese herbal medicine of aloe, skin absorption water medicine and dietary therapy |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2208397Y (en) * | 1994-08-03 | 1995-09-27 | 耿泰山 | Convenient hemostatic embolism for nasal-cavity |
| CN2877588Y (en) * | 2006-02-16 | 2007-03-14 | 赵燕 | Nasal hemostat |
| CN104740139A (en) * | 2012-01-05 | 2015-07-01 | 谢有珠 | Vegetative Chinese herbal medicine of aloe, skin absorption water medicine and dietary therapy |
| CN103479905A (en) * | 2013-08-28 | 2014-01-01 | 严中明 | Chinese medicinal composition for stomach excessive heat type epistaxis patients |
| CN203662835U (en) * | 2014-01-10 | 2014-06-25 | 樊鹂 | Disposable cotton swab with haemostatic drugs |
| CN104206837A (en) * | 2014-08-16 | 2014-12-17 | 严中明 | Pig fattening additive |
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Application publication date: 20160106 |