CN105213262A - A kind of NO/cGMP protease cell neogenesis stock solution and preparation method thereof - Google Patents
A kind of NO/cGMP protease cell neogenesis stock solution and preparation method thereof Download PDFInfo
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- CN105213262A CN105213262A CN201510713646.9A CN201510713646A CN105213262A CN 105213262 A CN105213262 A CN 105213262A CN 201510713646 A CN201510713646 A CN 201510713646A CN 105213262 A CN105213262 A CN 105213262A
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- cgmp
- stock solution
- extract
- skin
- protease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/645—Proteins of vegetable origin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Abstract
The present invention relates to a kind of NO/cGMP protease cell neogenesis stock solution, it is characterized in that, it comprises containing following component by percentage to the quality: Herba portulacae extract 1-6%, camomile extract 2-6%, aloe vera extract 1-3%, Radix Astragali extract 1-2%, hydrolysis avenin 0.5-2%, hyaluronate sodium 5-10%, hydrogenated polydecene 3-5%, wetting agent 10-20%, pH adjusting agent 0.1-3%, antiseptic 0.1-1%, excess water.Above-mentioned active substance is carried out reasonable compatibility by the present invention, by the protease that above-mentioned active substance produces, activate the NO in dermis of skin confluent monolayer cells, synthesis cGMP, kills the long pox cell in pilosebaceous unit, the secretion of balance hair follicle sebocyte cell, and then by repairing and promoting that Skin Cell regenerates, recover skin health, reach radical cure acne, repair Acne Scar, recover object that is delicate and smooth healthy skin.
Description
Technical field
The present invention relates to cosmetic technical field, be specifically related to a kind of NO/cGMP protease cell neogenesis stock solution.
Background technology
At present, the raising gradually of living standard, along with the growth at age and the increase of life and work pressure, skin senesces gradually, and the skin problem such as drying, microgroove, dim mute, melanin deposition comes one after another.Acne is also known as comedo, and acne and skin sore, infect primarily of anaerobic propionibacterium acnes and cause, belong to pilosebaceous chronic dermatosis, in the treatment of comedo and acne, mainly use antibiotic traditionally.Although the comedo for the treatment of method to general or local has certain curative effect, life-time service can make bacterial resistance occurred.1993, the research of Britain 400 many cases acne patient is being shown have 40% to show Drug resistance to one or more antibacterial in these patients.Although also there are some acne-eliminating cosmetics, rebound rate is higher.
Summary of the invention
The object of the invention is to the defect overcoming prior art, there is provided a kind of and promote hair follicle sebum glandular secretion balance, antiinflammatory and injury repairing, promote the cellular-restoring secretion balance in sebaceous gland simultaneously, thus the NO/cGMP protease cell neogenesis stock solution of radical cure acne, provide its preparation method simultaneously.
To achieve these goals, the technical scheme taked of the present invention is as follows:
Technical scheme one:
A kind of NO/cGMP protease cell neogenesis stock solution, it comprises containing following component by percentage to the quality:
Further improve as the present invention, it comprises containing following component by percentage to the quality:
Further improve as the present invention, described wetting agent be selected from glycerol, propylene glycol and butanediol one or more.
Further improve as the present invention, described antiseptic be selected from phenoxyethanol, methyl hydroxybenzoate, ethyl hydroxybenzoate, propyl hydroxybenzoate, sorbic acid, benzoic acid one or more.
Further improve as the present invention, described pH adjusting agent be selected from triethanolamine, arginine or amino-propanediol one or more.
Technical scheme two:
A preparation method for essence is repaired by a kind of described cell regeneration unit of technical scheme, specifically comprises the following steps:
With water, hydrogenated polydecene is disperseed, be warming up to 90-100 DEG C, add wetting agent and stir 10-15min, be cooled to 35-45 DEG C, add Herba portulacae extract, camomile extract, aloe vera extract, Radix Astragali extract, hydrolysis avenin, hyaluronate sodium, PH regulator and antiseptic, stir, be down to room temperature, obtain product.
Compared with prior art, the beneficial effect acquired by the present invention is as follows:
Herba portulacae extract in the present invention also claims Herba Angelicae Keiskei in China, is rich in the compounds such as a large amount of flavonoids, adrenin, polysaccharide and various vitamin, aminoacid wherein.In cosmetics: the various stimulations being mainly used in antiallergic, antiinflammatory antiinflammatory and anti-outer bound pair skin, acne-removal function in addition.Obvious anti-allergic effects is had especially to the skin allergy that life-time service hormones cosmetics produce.
Camomile extract in the present invention can suppress inflammation, healing of wound, and it has the effect of sterilizing, maintenance laceration of skin; Be used in maintenance, moisturizing can be had, the calm skin restrain pore of releiving; Add that there is refrigerant, to help skin tissue regeneration effect.
Containing glucose, mannose, alduronic acid, calcium, hydrated protein enzyme, bio-hormone, hormone, protein, aminoacid, vitamin, mineral and other trace element in aloe vera extract in the present invention, therefore there is nourishing and moisturizing, sun-proof, effect such as Hang Yan, hair-dressing and hair care, meanwhile, it to softening skin, restrain, prevent and treat acne, prevent pachylosis, anti-inflammatory anti-itch, hair care, the delicate Bai Jie of maintenance skin etc. have remarkable efficacy.Aloe has good compatibility, can coordinate well, and can eliminate the injury of kinds of surface activating agent to skin with the brilliant raw material of various cosmetic.
Radix Astragali extract in the present invention possesses invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, the effect of expelling pus and promoting granulation, and Radix Astragali saponin can activate cells in vivo NO-cGMP system.
Hyaluronate sodium in the present invention can stop the generation of some enzymes in cell, reduce the formation of free radical, destroy cellularity preventing free radical, produce lipid peroxidation and cause the important roles such as senility of humanbody: low-molecular-weight hyaluronic acid has antiinflammatory, suppresses pathogenic bacteria to produce, keeps the effect that skin is bright and clean; For cell proliferation and differentiation provide suitable place, direct Promote cell's growth, differentiation, reconstruction and reparation etc.
Hydrolysis avenin in the present invention and " cytokine " in skin closely similar, after percutaneous absorption, the generation of new cell can be improved, new cell is emerged in large numbers, promote skin metabolism.
Above-mentioned active substance is carried out reasonable compatibility by the present invention, by the protease that above-mentioned active substance produces, activate the NO (nitric oxide) in dermis of skin confluent monolayer cells, synthesis cGMP (cyclic guanosine monophosphate), kills the long pox cell in pilosebaceous unit, the secretion of balance hair follicle sebocyte cell, and then by repairing and promoting that Skin Cell regenerates, recover skin health, reach radical cure acne, repair Acne Scar, recover object that is delicate and smooth healthy skin.
Detailed description of the invention
Below in conjunction with specific embodiment, detailed further describing is carried out to the present invention.
Embodiment 1
A kind of NO/cGMP protease cell neogenesis stock solution, it comprises containing following component by percentage to the quality:
With water, hydrogenated polydecene is disperseed, be warming up to 90-100 DEG C, add glycerol and propylene glycol stirring 10-15min, be cooled to 35-45 DEG C, add Herba portulacae extract, camomile extract, aloe vera extract, Radix Astragali extract, hydrolysis avenin, hyaluronate sodium, triethanolamine and methyl hydroxybenzoate, stir, be down to room temperature, obtain product.
Embodiment 2
A kind of NO/cGMP protease cell neogenesis stock solution, it comprises containing following component by percentage to the quality:
With water, hydrogenated polydecene is disperseed, be warming up to 90-100 DEG C, add glycerol and stir 10-15min, be cooled to 35-45 DEG C, add Herba portulacae extract, camomile extract, aloe vera extract, Radix Astragali extract, hydrolysis avenin, hyaluronate sodium, arginine and phenoxyethanol, stir, be down to room temperature, obtain product.
Embodiment 3
A kind of NO/cGMP protease cell neogenesis stock solution, it comprises containing following component by percentage to the quality:
With water, hydrogenated polydecene is disperseed, be warming up to 90-100 DEG C, add propylene glycol and stir 10-15min, be cooled to 35-45 DEG C, add Herba portulacae extract, camomile extract, aloe vera extract, Radix Astragali extract, hydrolysis avenin, hyaluronate sodium, triethanolamine and ethyl hydroxybenzoate, stir, be down to room temperature, obtain product.
Effect example:
Choose 100 volunteers, 13 years old ~ 38 years old age, average 23 years old, each 50 of men and women.All there are pimple, pustule, pockmark in face.
Using method: after clean, gets appropriate embodiment 1 and prepares sample and spread upon affected part, be massaged into gently and absorb completely, and twice daily, using for 1 course for the treatment of continuously, 4 weeks is a course for the treatment of.
Curative effect: skin lesion counting × 100% before curative effect=(before treatment the rear skin lesion counting of skin lesion counting-treatment)/treatment
Effective: skin lesion disappears 60% ~ 90%, and symptom alleviates;
Effective: skin lesion disappears 20% ~ 60%, symptom is improved;
Invalid: skin lesion disappears < 20%, and clinical symptoms is not improved;
Result: effective percentage is 93%.
The above embodiment is only the preferred embodiments of the present invention, and and the feasible enforcement of non-invention exhaustive.For persons skilled in the art, to any apparent change done by it under the prerequisite not deviating from the principle of the invention and spirit, all should be contemplated as falling with within claims of the present invention.
Claims (6)
1. a NO/cGMP protease cell neogenesis stock solution, is characterized in that, it comprises containing following component by percentage to the quality:
2. a kind of NO/cGMP protease cell neogenesis stock solution according to claim 1, is characterized in that, it comprises containing following component by percentage to the quality:
3. a kind of NO/cGMP protease cell neogenesis stock solution according to claim 1, is characterized in that, described wetting agent be selected from glycerol, propylene glycol and butanediol one or more.
4. a kind of NO/cGMP protease cell neogenesis stock solution according to claim 1, is characterized in that, described antiseptic be selected from phenoxyethanol, methyl hydroxybenzoate, ethyl hydroxybenzoate, propyl hydroxybenzoate, sorbic acid, benzoic acid one or more.
5. a kind of NO/cGMP protease cell neogenesis stock solution according to claim 1, is characterized in that, described pH adjusting agent be selected from triethanolamine, arginine or amino-propanediol one or more.
6. a preparation method for the NO/cGMP protease cell neogenesis stock solution as described in any one of claim 1-5, is characterized in that, specifically comprise the following steps:
With water, hydrogenated polydecene is disperseed, be warming up to 90-100 DEG C, add wetting agent and stir 10-15min, be cooled to 35-45 DEG C, add Herba portulacae extract, camomile extract, aloe vera extract, Radix Astragali extract, hydrolysis avenin, hyaluronate sodium, PH regulator and antiseptic, stir, be down to room temperature, obtain product.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510713646.9A CN105213262A (en) | 2015-10-29 | 2015-10-29 | A kind of NO/cGMP protease cell neogenesis stock solution and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510713646.9A CN105213262A (en) | 2015-10-29 | 2015-10-29 | A kind of NO/cGMP protease cell neogenesis stock solution and preparation method thereof |
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| CN105213262A true CN105213262A (en) | 2016-01-06 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105662948A (en) * | 2016-01-20 | 2016-06-15 | 北京莱伊莲生物科技有限责任公司 | Low-irritation nicotinamide composition |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102101880A (en) * | 2009-12-17 | 2011-06-22 | 北京大学 | Preparation method and application of radix astragali saponin |
| CN103271855A (en) * | 2013-05-23 | 2013-09-04 | 苏州谷力生物科技有限公司 | Skincare water for removing acnes and preparation method thereof |
| CN103751081A (en) * | 2014-01-26 | 2014-04-30 | 广东景兴卫生用品有限公司 | Natural anti-acne conditioner and preparation process thereof |
-
2015
- 2015-10-29 CN CN201510713646.9A patent/CN105213262A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102101880A (en) * | 2009-12-17 | 2011-06-22 | 北京大学 | Preparation method and application of radix astragali saponin |
| CN103271855A (en) * | 2013-05-23 | 2013-09-04 | 苏州谷力生物科技有限公司 | Skincare water for removing acnes and preparation method thereof |
| CN103751081A (en) * | 2014-01-26 | 2014-04-30 | 广东景兴卫生用品有限公司 | Natural anti-acne conditioner and preparation process thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105662948A (en) * | 2016-01-20 | 2016-06-15 | 北京莱伊莲生物科技有限责任公司 | Low-irritation nicotinamide composition |
| CN105662948B (en) * | 2016-01-20 | 2018-03-09 | 北京莱伊莲生物科技有限责任公司 | The nicotinoyl amine composition of low irritant |
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Application publication date: 20160106 |
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