CN105163662A - Method and device for measuring venous blood oxygenation - Google Patents

Method and device for measuring venous blood oxygenation Download PDF

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Publication number
CN105163662A
CN105163662A CN201480021054.4A CN201480021054A CN105163662A CN 105163662 A CN105163662 A CN 105163662A CN 201480021054 A CN201480021054 A CN 201480021054A CN 105163662 A CN105163662 A CN 105163662A
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light
patient
wavelength
apparatus
light source
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CN201480021054.4A
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Chinese (zh)
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程雪峰
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米斯比尔生命科学公司
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Priority to US13/765,843 priority Critical patent/US8918153B2/en
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Priority to PCT/CA2014/000106 priority patent/WO2014124520A1/en
Publication of CN105163662A publication Critical patent/CN105163662A/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/026Measuring blood flow
    • A61B5/0295Measuring blood flow using plethysmography, i.e. measuring the variations in the volume of a body part as modified by the circulation of blood therethrough, e.g. impedance plethysmography
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A61B5/14552Details of sensors specially adapted therefor

Abstract

A device for non-invasively measuring at least one parameter of a cardiac blood vessel in a patient comprises at least one light source that directs light at a tissue site on the patient; at least one photodetector adapted to receive light emitted by the light source and generate an output based on the received light, the output of said photodetector being correlated with a parameter of the blood vessel; and at least one probe for facilitating delivery of light from the light source to the tissue site, and receipt of light by the photodetector. The device may include a height sensor to adapt it for use to determine central venous pressure, or the configuration of light source(s) and photodetector(s) may be adapted to permit the device to provide attenuation correction in the determination of venous blood oxygenation.

Description

用于测量静脉血氧的方法和装置发明领域 Field of the invention a method and apparatus for measuring the venous blood oxygen

[0001] 本发明设及用于监测人体的生命机能,包括屯、脏功能如屯、输出量和中屯、静脉血氧的技术。 Invention is provided [0001] for the present and monitoring human vital functions, including Tun, Tun features such as dirty, and output Tun, venous oxygen technology. 它具体地设及用于非侵入性和连续监测屯、脏参数如血流、血量和血氧饱和度的光学方法和装置。 It is specifically provided for noninvasive and continuous monitoring and Tun, dirty parameters such as blood flow, blood volume and optical method and apparatus for oxygen saturation.

[0002] 发巧背景 [0002] made clever background

[0003] 对颈静脉搏动的评估已经成为屯、血管检查的必要组成部分,并且具有重要的临床诊断价值[1-2]。 [0003] evaluation of the JVP has become a village, a necessary part of the vessel inspection, and has important clinical diagnostic value [1-2]. 颈静脉搏动是由右屯、房和屯、室的充盈和收缩引起的中屯、静脉血流和压力变化产生的。 JVP is in the village, venous blood flow and pressure changes caused by the contraction of the right and filling Tun, and Tun housing chamber produced. 颈静脉搏动的床旁检查的两个主要目的包括评估中屯、静脉压力和检查波形。 The main purpose of the two JVP bedside testing includes evaluation Tun, venous pressure and inspect the waveform. 由于右颈内静脉更直接通向右屯、房,对于此目的来说W右颈内静脉为最优。 Since more direct Tuen right through the right internal jugular vein, room, for this purpose it is within the W right internal jugular vein is the best. 根据运些测量, 医生可W获知右屯、房的血流动力学事件,并由此诊断屯、脏疾病和异常。 According to transport these measurements, W doctors can learn the right Tuen hemodynamic events, housing, and thus the diagnosis Tuen, dirty diseases and disorders. 例如,颈静脉压升高的最常见原因是右屯、室压力升高,例如在肺动脉狭窄、肺动脉高压、右屯、室梗死继发的右屯、 室衰竭患者中所发生的。 For example, the most common cause is the right jugular venous pressure Tun, the chamber pressure is increased, for example, pulmonary stenosis, pulmonary hypertension, right Tun, right ventricular infarction secondary to Tun, Ventricular failure occurred. 当右屯、室流入道发生阻塞时,例如患有=尖瓣狭窄或右屯、房粘液瘤时,或者当缩窄性屯、包疾病阻碍右屯、室流入道时,静脉压也升高。 When blocking the right Tun, inflow chamber occurs, for example, having a right or stenosis = cusps Tun, when atrial myxoma, or when the constrictive Tun, Tun packet diseases hinder the right, chamber inflow, venous pressure also rises . 它还可能由腔静脉阻塞W及偶尔的血量升高导致。 It also may block W and occasionally lead to elevated blood from the vena cava. 患有阻塞性肺病的患者可能仅在呼气时静脉压升高。 Patients with obstructive pulmonary disease could only exhale venous pressure.

[0004] 用于测量静脉搏动和波形的传统技术在文献中已有描述巧]。 Conventional techniques [0004] waveforms for measuring the venous pulse in the literature and have been described Qiao]. 将患者身体抬高到最佳程度进行检查W观察静脉搏动。 Raise the patient's body to the best extent observed to check W venous pulse. 通过标尺来测量静脉压,测量的是振荡静脉柱顶端到胸骨角水平的垂直距离,加上其至右屯、房的垂直距离。 Venous pressure measured by the scale, the top of the oscillation is measured sternal angle to the horizontal column vein vertical distance, with its vertical distance to the right Tun, room. 由于静脉搏动一般非常微弱,而且由于患者有并发症,运种方法对于医生使用来说是有挑战性的,并且仅能提供近似值。 Due to venous pulsation generally very weak, and because patients have complications, transportation methods is challenging for doctors to use it, and can only provide approximate. 阳〇化]屯、输出量定义为每分钟循环的血量。 Of male square] Tun, the output is defined as the amount of circulating blood volume per minute. 它等同于屯、率乘W每搏输出量(屯、脏每次收缩射出的血量)。 It is equivalent to village, by W of stroke volume (Tun, each contraction emitted dirty blood). 屯、输出量对于屯、血管健康的监测是至关重要的[4]。 Tun, Tun for output, vascular health monitoring is essential [4]. 对循环系统状况的准确临床评估对于ICU中的危重患者和接受屯、脏、胸部或血管介入的患者尤其需要,并且已经在口诊治疗的长期随访中证明是有价值的。 Accurate assessment of the clinical status of the circulatory system for critically ill patients in the ICU and receiving Tun, patients dirty, chest or vascular intervention is particularly needed, and has proven to be valuable in the long-term follow-up of the mouth diagnosis treatment. 由于患者的血液动力学状况可能迅速改变, 因此持续监测屯、输出量将会提供信息,使得能够迅速调整治疗。 As the patient's blood dynamics situation could change quickly, so continuous monitoring Tuen, output will provide information, making it possible to quickly adjust treatment. 对屯、输出量和血压的测量还可W用于计算外周阻力。 Tun measurement, output and blood pressure may also be used to calculate W peripheral resistance.

[0006] Jansen(JRCJansen,"Novelmethodsofinvasive/non-invasivecardiac outputmonitoring",Abstractsofthe7thannualmeetingoftheEuropeanSociety forIntravenousAnesthesia,Lisbon2004)描述了屯、输出量监测技术的八个理想特征: 准确度、重复性或精确度、快速响应时间、操作者独立性、易于使用、连续使用、成本效益W 及不增加死亡率和发病率。 [0006] Jansen (JRCJansen, "Novelmethodsofinvasive / non-invasivecardiac outputmonitoring", Abstractsofthe7thannualmeetingoftheEuropeanSociety forIntravenousAnesthesia, Lisbon2004) described Tun, over the eight output monitoring technology feature: accuracy, precision or repeatability, fast response time, operator independence, ease of use, continuous use, cost-effective and W does not increase mortality and morbidity.

[0007] 肺动脉导管(PAC)热稀释方法通常被接受作为监测屯、输出量的临床标准,所有其他方法都与之进行比较,如Conway和Lund-Johansen[6]所讨论的。 [0007] The pulmonary artery catheter (PAC) thermodilution method is generally accepted as a monitoring Tun, output of clinical criteria, with all other methods are compared, such as Conway and Lund-Johansen [6] discussed. 由于运项技术是高度侵入性的、复杂的W及昂贵的,因此已经开发了许多新的方法试图来代替它,但是迄今为止还没有其他方法被接受。 The arrival of technical terms is highly invasive, complex and expensive W, and therefore have developed many new methods attempt to replace it, but so far there is no other way to be accepted. 对于测量屯、输出量的各种技术的近期综述在Linton和Gilon的文章[5]中给出。 [5] For the measurement given village, a recent review of the various techniques of the output of articles in Linton and Gilon. 运篇文章列举了非侵入性/微创和侵入性方法,并比较了每种方法的优点和缺点。 Transport article lists the non-invasive / minimally invasive and invasive methods, and compared the advantages and disadvantages of each method. 对运些技术中的一部分简述如下。 Op art some part briefly described as follows.

[0008] 指示剂稀释技术存在几种指示剂稀释技术,包括经肺热稀释(也被称为PiCCO技术,PulsionMedicalTechnologiesofMunich,Germany)、经肺裡稀释法(XiDCOGroup picofLondon,UK)、基于PAC的热稀释和其他方法(Vigilance,Baxter;0pti-Q,Abbott; 和TruCCOMS,AorTech)。 There are several indicator dilution technique [0008] indicator dilution technique, including thermal dilution undiluted Hyperactivity (also referred PiCCO technology, PulsionMedicalTechnologiesofMunich, Germany), dilution (XiDCOGroup picofLondon, UK) by the lungs, PAC-based and other methods (Vigilance, Baxter; 0pti-Q, Abbott; and TruCCOMS, AorTech). 运些技术的应用有S个主要的假定条件,即,血液和指示剂完全混合,在注射部位和检测部位之间没有指示剂损失,W及血流恒定。 Application of these techniques are shipped S major assumptions, i.e., complete mixing of blood and an indicator, the indicator is not lost between the injection site and the detection site, W, and the blood flow constant. 指示剂稀释技术的相关错误主要与运些条件的违反有关,如Lund-Johansen[7-引所讨论的。 Related error indicator dilution technique is mainly related to transportation in violation of these conditions, such as the Lund-Johansen [7- cited in question.

[0009] 菲克原理直接氧菲克方法(direct0巧genPickapproach)目前是屯、输出量测量的标准参照技术,如Keinanen等巧-10]所讨论的。 [0009] Fick principle of direct oxygen Fick method (direct0 Qiao genPickapproach) is now a standard village, a reference output measuring techniques, such as Keinanen et Qiao -10] discussed. 其一般被认为是目前可用的最准确的方法。 Which it is generally considered the most accurate method currently available. NICO(Novamet;rix)系统是一种非侵入性装置,其利用菲克原理(Fick'sprinciple), 并且仅依赖于呼吸道气体测量,如Botero等[11]所述。 NICO (Novamet; rix) system is a non-invasive device using Fick principle (Fick'sprinciple), and depends only on the respiratory gas measurement, such as Botero et al [11]. 该方法显示出在热稀释和CO厂重复呼吸屯、输出量之间缺乏一致性,如Nielsson等[12]所述,运是由于未知的患者通气/灌注的不等性导致的。 This shows the thermal dilution method and plant rebreathing CO village, lack of consistency between output as Nielsson et al [12], transport is due to an unknown patient ventilation / perfusion inequality caused.

[0010] 生物阻抗和传导技术生物阻抗方法是作为一种简单、低成本的方法被开发的,其W非侵入性的方式给出了有关屯、血管系统和/或身体的水合(脱水)状态((de)-hy化ationsta化S)的信息。 [0010] bioimpedance bioimpedance method and transfer technology as a simple, low-cost method is developed which W is given by way of non-invasive about Tun, vascular system and / or body hydration (dehydration) state ((de) -hy of ationsta of S) information. 多年来,也开发了多种胸阻抗测量系统。 Over the years, also developed a variety of thoracic impedance measurement system. 运些系统在逐博时间的基础上测定C0。 C0 operation of these systems was measured on the basis of the time by Bo. 已报道的研究大多效果较差,但是在一些特殊情况中与参照方法具有较好的相关性。 Most studies have reported poor results, but in some special cases have a good correlation with the reference method. 许多运样的研究引用胸阻抗方法的不理想的物理原理来解释其差异,女曰P曰tterson"Fundament曰Isofimped曰neec曰rdio邑r曰phy",IEEEEngineeringin MedicineandBiology1989 ;35 所述。 Many undesirable physical principle studies thoracic impedance reference sample transport method to explain the difference, said P said female tterson "Fundament said Isofimped said neec said rdio r Yap said phy", IEEEEngineeringin MedicineandBiology1989; 35 a.

[0011] 回波多普勒超声运种技术使用超声和多普勒效应来测量屯、输出量。 [0011] The use of ultrasound and Doppler effect to measure Tun, the output of op ultrasound echo doppler techniques. 流过主动脉的血流速度引起返回超声波频率的"多普勒频移"。 Flowing through the aortic blood flow velocity caused by the return ultrasonic frequency "Doppler shift." 位于食管内,其回波窗在胸主动脉上的回波多普勒探头可用于测量主动脉流速,如Schmidlin等[13]所讨论的。 Within the esophagus, which echoes back window on the Doppler probe can be used to measure thoracic aorta aortic flow, such Schmidlin et al. [13] discussed. 主动脉横截面积在装置例如由Deltex Medical化C, Qiichester, UK制造的CardioQ中被呈现,或者例如在由Arrow International制造的化moSonic装置中被同时测量。 Aortic cross-sectional area of ​​Deltex Medical devices, such as a C, Qiichester, CardioQ UK manufactured is presented, for example, or of simultaneously measuring apparatus manufactured by moSonic Arrow International's. 利用运些微创技术测量的是主动脉血流,而非屯、输出量。 The use of transport slightly invasive technique measures the aortic flow, rather than the village, output. 假设在主动脉血流和屯、输出量之间存在固定关系。 Suppose there is a fixed relation between the aorta and Tun, output. 回波多普勒超声要求超声机器的操作者具有平均水平W上的技术,W获得准确可靠的结果。 Ultrasound echo Doppler ultrasound requires operator of the machine having the average technology W, W to obtain accurate and reliable results. 阳012] 动脉搏动波形分析基于搏动波形分析(pulsecontouranalysis)对屯、输出量的评估是一种间接方法,因为屯、输出量不是直接被测量,而是在标准或模型的基础上由压力脉动计算而得到的[14-17]。 Male 012] beat arterial pulse waveform analysis Waveform Analysis (pulsecontouranalysis) assessment of Tun, the output is an indirect method, because Tun, output is not directly measured, but is calculated based on the pressure pulsation on the basis of a standard or model obtained [14-17]. 目前可用的有S种搏动波形方法:PiCCO(Pulsion)、 化IseCO(LiDCO)和Modelflow灯N0/BMI)。 There are currently available kinds of beating waveform Method S: PiCCO (Pulsion), of IseCO (LiDCO) and Modelflow lamp N0 / BMI). 所有运S种搏动波形方法都要使用侵入性测量的动脉血压,而且它们需要进行校准。 All kinds of beating waveform S transported methods have to use invasive arterial blood pressure measurement, and they need to be calibrated. PiCCO通过经肺热稀释校准,LiDCO通过经肺裡稀释校准,而Modelflow通过平均分布在通气循环中的3个或4个传统热稀释测量的平均值来校准。 PiCCO calibrated by thermodilution, by calibrated by diluting Lidco lungs, and by calibrating Modelflow average of three or four conventional thermodilution measurements evenly distributed in the ventilation cycle.

[0013] 近红外光谱已被用于在动物和人受试者中非侵入性地测量各种生理性质。 [0013] Near-infrared spectroscopy has been used in animal and human subjects noninvasive measurement of various physiological properties. 近红外光谱的基本原理是生理介质例如组织包括多种光吸收(发色团)和光散射物质,运些光吸收(发色团)和光散射物质可与透过的低能量近红外光子相互作用。 The basic principles of the near-infrared spectrum is a physiological medium such as tissue includes a plurality of light absorbing (chromophore) and the light scattering material, light absorption of these transport (chromophore) and the light scattering material may be near-infrared photons with low energy through interactions. 例如人血液中的脱氧血红蛋白和氧合血红蛋白是400皿至1000皿的光谱范围内的最主要的发色团。 For example deoxygenated hemoglobin and oxygenated hemoglobin in human blood is the most important chromophore in the spectral range 400 to 1000 dish to dish. 因此散射光谱已被用于非侵入性地测量生理介质中的氧水平,其依据的是组织血红蛋白氧饱和度。 Thus scattering spectroscopy has been used to noninvasively measure oxygen levels in the physiological medium, which is based on the tissue hemoglobin oxygen saturation. 散射光谱的技术背景已在例如化uman,MR,化Ise Oximetry:PhysicalPriciples,TechnicalRealizationandPresentLimitations, @ Adv.Exp.Med.Bio. ,vol. 220,p. 135-144, 1987和Severin曲aus,JW ,HistoiyandRecent DevelopmentsinPluseOximetry,iScan.J.Clin,andLab.Investigations,vol. 53 ,p. 105-111,1993 中进行了讨论。 BACKGROUND ART scattering spectrum has been example of uman, MR, of Ise Oximetry: PhysicalPriciples, TechnicalRealizationandPresentLimitations, @ Adv.Exp.Med.Bio, vol 220, p 135-144, 1987, and Severin curved aus, JW, HistoiyandRecent... DevelopmentsinPluseOximetry, iScan.J.Clin, andLab.Investigations, vol. 53, in p. 105-111,1993 discussed.

[0014] 因为组织对于可见光和近红外光(400nm-1000nm)的高度散射性质,难W非侵入性地应用散射光谱来选择组织内的血管计算血氧。 [0014] Because the scattering properties of tissue for highly visible and near-infrared light (400nm-1000nm), it is difficult to apply W noninvasive vascular selected scattering spectrum calculation oxygen within the tissue. 因此散射光谱仅被用于测量组织介质内动脉、静脉和毛细血管的血液的综合或平均氧合。 Thus scattering spectroscopy is used only for the integrated or average blood tissue oxygenation measuring medium arteries, veins and capillaries. 然而,在许多临床应用中,希望知道具体血管的血氧。 However, in many clinical applications it is desirable to know specific oxygen blood vessels. 为此,已开发了多种侵入性方法,其中需要使用必须被插入到祀血管中W进行测量的导管。 To this end, we have developed a variety invasive method, which requires the use of Si must be inserted into a blood vessel catheter measurement performed W.

[0015] 上文提及的测量屯、输出量的技术中,没有一种综合有上文提及的全部八个"Jansen"标准,并且,因此,没有一种能够代替如Jansen等[1引所述的传统的热稀释技术。 [0015] The above-mentioned measurement Tun, output of the art, none have integrated all of the above-mentioned eight "Jansen" criteria and, therefore, none can replace such Jansen et [1 primer conventional thermodilution techniques described. 虽然它是高度侵入性的、复杂的和昂贵的,但是传统的热稀释方法仍然是测量屯、输出量的首选方法。 Although it is highly invasive, complex and expensive, conventional thermodilution method Tun is still the preferred method of measuring output quantities. 鉴于此,非常希望开发一种准确、可靠、低成本并易于使用的在临床环境下实时监测屯、输出量的非侵入性方法。 In view of this, highly desirable to develop an accurate, reliable, real-time monitoring Tuen low cost and easy to use in a clinical setting, the output of non-invasive methods. 发巧简沐 Faqiaojianmu

[0017] 本发明提供了装置、系统和方法,由此能够通过对静脉血流、静脉血压和血液成分包括血氧进行光学测量,从而W非侵入性的方式连续监测屯、脏参数。 [0017] The present invention provides an apparatus, system and method whereby venous blood flow through venous blood oxygen and blood components comprising optical measurement, whereby W non-invasive continuous monitoring of Tun, dirty parameters.

[0018] 具体地,在本发明的一个方面,提供了非侵入性测量静脉血氧(venousblood o巧genation)的装置,包括: [0018] Specifically, in one aspect of the invention there is provided a non-invasive device for measuring venous oxygen (venousblood o clever genation), comprising:

[0019] -个或多个光源,W发射400nm至lOOOnm波长范围内的至少两种不同波长的光, 波长1和波长2 ; [0019] - one or more light sources, W emits at least light, wavelength 1 and wavelength 2 at two different wavelengths of the wavelength range of 400nm to lOOOnm;

[0020] 一个或多个光探测器,W接收由所述一个或多个光源发射的波长1和波长2的光, 并将所述光转换为可记录的输出,其中所述光由患者组织反射而来或者透射穿过患者组织,其中发射和接受波长1的光的光源和光探测器之间的距离与发射和接受波长2的光的光源和光探测器之间的距离不同;W及 [0020] one or more light detectors, the wavelength 1 and the wavelength emitted by the W received one or more light source 2, and the output light is converted to be recorded, wherein the light emitted by the patient's tissue reflected from or transmitted through the patient's tissue, wherein the transmitting and receiving distance between the emission wavelength of the light source and the light detector receiving the light and a wavelength different distances between the light source and the light detector 2; and W is

[0021] 至少一个探头,其有利于光从所述光源向靠近颈静脉的患者外部组织部位的传送和所述光探测器对所述患者部位反射而来的光或者透射穿过所述患者部位的光的接收。 [0021] at least one probe, which facilitates transmission of light from the light detector and the light source external to the tissue site near the patient's jugular vein to the light reflected from or transmitted through the patient locations patient locations receiving light.

[0022] 在本发明的另一个方面,提供了确定患者静脉血氧的方法,包括W下步骤: [0022] In another aspect of the present invention, there is provided a method for determining a patient's venous oxygen, W comprises the steps of:

[0023] 使来自一个或多个光源的具有第一和第二波长的光对准靠近颈内静脉或颈外静脉的患者外部组织部位,所述第一和第二波长不同且选自400-1000nm的波长范围; [0023] from one or more light sources so that the alignment of the first and second light having a wavelength close to the external jugular vein or external jugular vein of a patient tissue site, the first and second wavelength different and are selected 400- 1000nm wavelength range;

[0024] 使用一个或多个光探测器,在第一和第二波长检测由所述组织反射而来的光或者透射穿过所述组织的光,并将检测到的光转换为第一和第二波长的输出电流,其中发射和接受波长1的光的光源和光探测器之间的距离与发射和接受波长2的光的光源和光探测器之间的距离不同;W及 [0024] using one or more light detectors, the first and second light conversion wavelength of the detection light reflected by the tissue is tissue from or transmitted through the light, and the detected first and output current of the second wavelength, wherein the transmitting and receiving distance between the emission wavelength of the light source and the light detector receiving the light and a wavelength different distances between the light source and the light detector 2; and W is

[00巧]使用处理器根据每一波长的光衰减确定所述患者外部组织部位的衰减校正,并对测量得到的静脉血氧应用该衰减校正,W确定静脉血氧。 [Qiao 00] using a processor to determine the light attenuation of each attenuation correction wavelength outside the patient according to the tissue site, and measured the attenuation correction applied venous oxygen, W is determined venous oxygen.

[00%] 在本发明的另一个方面,提供了装置,包括: [00%] In a further aspect of the present invention, there is provided an apparatus, comprising:

[0027] 至少一个光源,其适于发射400nm至lOOOnm波长范围的光; [0027] at least one light source adapted to light the wavelength range of 400nm to lOOOnm emission;

[0028] 至少一个光探测器,其适于接收由所述光源发射的光并将所述光转换为可记录的输出,其中所述光由患者组织反射而来或透射穿过患者组织; [0028] the at least one light detector adapted to receive light and the light emitted by the light source into an output may be recorded, wherein the light transmitted through or reflected from the tissue of the patient by the patient tissue;

[0029] 至少一个探头,其有利于光从所述光源向靠近颈静脉的患者外部组织部位的传送和所述光探测器对所述患者部位反射而来的光或者透射穿过所述患者部位的光的接收;W 及 [0029] at least one probe, which facilitates transmission of light from the light detector and the light source external to the tissue site near the patient's jugular vein to the light reflected from or transmitted through the patient locations patient locations received light; and W is

[0030] 安装在所述探头之上的高度传感器,所述高度传感器包括压力传感器,该压力传感器通过管与参考贴片相连,其中的管适于容纳液体。 [0030] mounted over the probe height sensor, the height sensor comprises a pressure sensor, the pressure sensor is connected by a pipe and a reference patch, wherein the tube is adapted to contain a liquid.

[0031] 通过参考下面的详细描述W及附图,本发明的运些和其他方面将会变得显而易见,其中: 阳〇扣]附图简沐 [0031] reference to the following detailed description, the accompanying drawings and W, the operation of the present invention These and other aspects will become apparent, wherein: the male buckle square] Brief reference Mu

[0033]图1是根据本发明一个方面的用于监测屯、输出量的装置的顶视图(A),W及该装置相对于屯、脏血管的放置度); [0033] FIG. 1 is according to one aspect of the present invention, a top view (A) monitoring Tun, the output of the device, W, and with respect to the apparatus Tun, dirty place of the blood vessel);

[0034] 图2是图1所示装置的侧视图; [0034] FIG. 2 is a side view of the apparatus shown in Figure 1;

[0035] 图3是包括图1装置的系统; [0035] FIG. 3 is a system including an apparatus of Figure 1;

[0036] 图4是使用图1所示装置产生的信号或波形; [0036] FIG. 4 is using a signal or waveform generating means shown in Figure 1;

[0037] 图5是包括图1所示装置的系统的方框图; [0037] FIG. 5 is a block diagram of the system shown in FIG. 1 apparatus comprising;

[0038] 图6是包括图1所示装置的另一个系统的方框图; [0038] FIG. 6 is a block diagram of another system including the apparatus of Figure 1;

[0039] 图7是包括多个光源和光探测器的发明的实施方案的顶视图(A,B); [0039] FIG. 7 is a top view (A, B) of an embodiment of the invention, a plurality of light sources and light detectors;

[0040] 图8是包括图7所示装置的系统的方框图; [0040] FIG. 8 is a block diagram of the system shown in FIG. 7 apparatus comprising;

[0041] 图9 (AC)是包括每一光源多个光探测器的发明的实施方案的顶视图; [0041] FIG. 9 (AC) is a top view of an embodiment of the invention, each of the plurality of light source detectors;

[0042] 图10是由图9的实施方案产生的双信号(波形); [0042] FIG. 10 is a dual signal (waveform) produced by the embodiment of Figure 9;

[0043]图11是根据本发明实施方案的屯、脏监测装置的顶视图,其包括多个传感器贴片; W44] 图12是使用根据本发明的装置获得的波形; [0043] FIG. 11 is a top view of the embodiment of the present invention Tun embodiment, the monitoring device according to the dirty, which comprises a plurality of sensors patches; W44] FIG. 12 is a waveform obtained using the apparatus according to the invention;

[0045] 图13是根据本发明另一个方面的装置的顶视图(A)和其放置在患者脖子上的视图做; [0045] FIG. 13 and which is placed on the patient's neck do view top view of another aspect of the present invention, apparatus (A) according to;

[0046] 图14是用于测量血压的装置的不同源-探测器配置(A、B和C); [0046] FIG. 14 is a different source device to measure blood pressure - probe configuration (A, B, and C);

[0047] 图15是使用根据图13做的装置在S个不同位置(A)获得的波形; [0047] FIG. 15 is a waveform using the apparatus of FIG. 13 according to the S made different positions (A) obtained;

[0048] 图16是方框图,其说明根据本发明的一个方面的系统; [0048] FIG. 16 is a block diagram that illustrates one aspect of the system according to the invention;

[0049] 图17示出了压力传感器与根据本发明一个实施方案的装置一起使用; [0049] FIG. 17 shows a pressure sensor for use with a device according to the embodiment of the present invention;

[0050] 图18示出了高度传感器与根据本发明一个实施方案的装置一起使用;W及 [0050] FIG. 18 shows a height sensor for use with a device according to the embodiment of the present invention; and W is

[0051] 图19是根据本发明的另一个方面的衰减校正装置(AI)。 [0051] FIG. 19 is an attenuation correction device to another aspect of the present invention (AI) in accordance with. 阳0。 Yang 0. ]发巧详沐 ] Qiao Long hair Mu

[0053]先前在W0 2008/098353中描述的用于测量患者屯、脏功能参数的装置10如图1A所示。 Figure 10 [0053] W0 2008/098353 previously apparatus for measuring a patient Tun, dirty functional parameters described 1A. 装置10包括:光源20,其发射400nm至lOOOnm波长范围的光,例如可见光和红外光; 光探测器30,其适于接收来自光源20(如图2所示)的光并将接收的光转换为输出信号;和贴片探头28,用于放置在靠近屯、脏血管的患者外部部位(如图1B所示),作为光源20/光探测器30和选定的外部患者部位之间的装置的接口。 10 apparatus comprising: a light source 20 which emits light 400nm to lOOOnm wavelength range, such as visible light and infrared light; a light detector 30, adapted to receive light from the light source 20 (FIG. 2) converts the received light and an output signal; and a patch probe 28, as between 20 / optical detector 30 and a light source external to the patient a selected site for placement of the device close to Tun, dirty part of the patient outside the vessel (FIG. 1B), Interface. 因此,探头28允许/有利于光源20 发射的光向选定的患者部位传送和患者部位反射而来的光或者透射穿过患者部位的光向光探测器30的传送。 Thus, the probe 28 to allow / facilitate the transfer of light through the patient to the site of the photodetector 30 is a light source 20 emits the light reflected from the selected portion of a patient and a patient transfer or transmit site. 为了产生可视信号,装置10可W另外包括信号处理部件40 (图3),其与光探测器30通讯,W将光探测器30接收的光转换为可记录的可视信号或屯、脏血管的波形(例如代表血管的可测量特征或参数,例如压力波形或中屯、静脉搏动,的时间进程图)。 In order to produce a visible signal, W device 10 may additionally include signal processing section 40 (FIG. 3), which correspond with 30, W photodetector 30 convert the light received by the light detector is a visible signal can be recorded or village, dirty vascular waveform (e.g. measurable characteristic or representative of a blood vessel parameters, such as pressure waveform or village, venous pulse, the temporal course).

[0054]光源20可W是任何适合的光源,例如激光二极管(例如化T7605G, 760nm, 5mW,sm, 9.Ommh,或化T8510MG, 850nm,lOmW,sm, 5. 6mm)、发光二极管(LED)或宽带光源,它们发射400nm至lOOOnm范围内的选定波长,例如780nm和850nm范围内的波长。 [0054] W light source 20 may be any suitable light source, such as a laser diode (e.g. of T7605G, 760nm, 5mW, sm, 9.Ommh, or of T8510MG, 850nm, lOmW, sm, 5. 6mm), a light emitting diode (LED ) or a broadband light source, which emit the selected wavelength 400nm to lOOOnm range, for example, within 780nm and 850nm wavelength range. 在一个实施方案中,光源适于发射两种或更多种波长的光,例如通过与变频器结合。 In one embodiment, the light source is adapted to emit two kinds of light wavelength or more, for example, by binding to the inverter. 光源20由适合的电源18例如12VDC电源提供能源。 18, for example the light source 20 powered by a 12VDC power supply suitable. 来自光源20的光对准非常靠近屯、脏血管的至少一个患者外部组织部位,所述屯、脏血管例如为颈内静脉、颈外静脉和颈动脉,虽然优选颈内静脉。 At least one outer portion very close to the tissue of the patient Tun, dirty vessel 20 from the light source of the alignment, the village, for example, vascular dirty internal jugular vein, external jugular vein and carotid artery, although preferably the jugular vein. 例如,脖子代表用于监测屯、脏参数的合适部位。 For example, the representative neck portion of a suitable monitoring Tun, dirty parameters. 阳化5] 如图5A/5B所示,在一个实施方案中,来自光源20的光可W通过光学透镜22对准或聚焦于发送装置24,例如发送光纤束(transmittingopticalfibrebundles),W发送至选定的患者部位。 Yang 5] shown in FIG. 5A / 5B, in one embodiment, the light from the light source 20 may be 22 W by the alignment or the optical lens is focused on the transmission device 24, such as sending fiber bundle (transmittingopticalfibrebundles), W delivered to the tune patients given site. 接收装置26,例如光纤束,也可用于接收由患者部位反射/透射的光并将该光传送至光探测器30 (图5A)。 The receiving apparatus 26, such as optical fiber bundles, may also be used by a patient receiving a reflected portion / light and transmitted light transmitted to the light detector 30 (FIG. 5A). 如本领域技术人员所知,每个光纤束将会包含由适合的材料制造的光纤,所述材料适于发送由光源20发射的所述波长的光。 As those skilled in the art, each optical fiber includes an optical fiber bundle will be made from a suitable material, said material is adapted to transmit the wavelength of light emitted from the light source 20. 例如,如果光源20发射的光在可见波长范围内,那么多模塑料和玻璃光纤都可W被使用。 For example, if the light source 20 emits light in the visible wavelength range, the multi-mode glass optical fiber and a plastic W can be used. 在特定的应用中,光纤束中光纤的数量和直径根据经验被优化W提供最高的信噪比。 In a particular application, the number and diameter of the optical fiber in the fiber bundle W is optimized empirically to provide the highest signal to noise ratio. 在图5A/5B所示的实施方案中,发送和接收光纤束24、26被设置在贴片探头28中,它们可W设置在不同的相隔开的位置,或者它们可W被组合设置在一个位置。 In the embodiment shown in 5A / 5B figure, for transmitting and receiving the optical fiber bundle 24, 26 are disposed in the patch 28 in the probe, they may be arranged in different W spaced apart locations, or they may be provided in combination in a W a position.

[0056] 如图6A/6C所示,光学镜29可用于使来自发送光纤束24的光对准或反射至选定患者部位的组织,并使来自患者部位的反射或透射光对准接收光纤束26 (图6A)。 [0056], an optical mirror 29 may be used to align the tissue or reflected from the light transmitting optical fiber bundle 24 to a selected portion of the patient, and the patient from a site or transmitted light are aligned in FIG. 6A / 6C receiving fiber beam 26 (FIG. 6A). 或者,光源20和光探测器30可W直接设置在贴片探头28中,运样就不需要光纤,如图6B所示。 Alternatively, the light source 20 and light detector 30 may be disposed directly on the patch W probe 28, the sample transport do not need an optical fiber, shown in Figure 6B. 在另一个实施方案中,可W使用前述实施方案的组合,其中光源20直接设置在探头28中,W 使光传送至患者部位,而反射/透射光被光纤26接收W传送至光探测器30。 In another embodiment, W may be a combination of the preceding embodiments, wherein the light source 20 is provided directly in the probe 28, the light transmitted to the patient W parts, and the reflection / transmission optical fiber 26 is transmitted to the light receiving detector 30 W . 也可W使用相反的实施方案,其中探头28包含发送光纤24,W使来自光源的光传送至患者部位,而光探测器30直接设置在探头28中,W接收反射/透射光(图6C)。 W may also be used contrary embodiment, wherein the transmission fiber 24 comprises a probe 28, W light from a light source is transmitted to the patient locations, the optical detector 30 is disposed directly in the probe 28, W receives reflected / transmitted light (FIG. 6C) . 相应地,光源20和光探测器30每一个都与探头28禪联(例如,与探头28连接、与探头28形成整体或直接设置在探头28 中)。 Accordingly, the light source 20 and light detector 30 are each (e.g., connected to the probe 28, the probe 28 is formed integrally with or disposed directly in the probe 28) of the probe 28 associated with Zen.

[0057] 光源20或发送光纤24与光探测器30或接收光纤26可W被设置在同一个贴片探头28中,或者可W被设置在不同的贴片探头28中,W便放置在距光探测器30或接收光纤26适当距离内的不同患者部位,W允许检测反射/透射光。 [0057] The light transmitting optical fiber 20 or 24 and the light detector receiving the optical fiber 30 or 26 may be provided at the same W patch probe 28, or may be disposed at different W patch probe 28, it is placed at a distance W 26 parts of different patients within a suitable distance from the detector 30 or the light receiving fiber, W allows detecting reflected / transmitted light. 使光传送至患者部位的部件(光源或发送光纤)和接收来自患者部位的光的部件(光检测器或接收光纤)之间的距离可W随每一个部件的性质而有所不同,虽然典型的距离通常是在2和4cm之间,例如,3cm。 That the distance member (or light transmitting optical fiber) and a light receiving member from the patient site (photodetector or receive fiber) optical transport the patient to the site between W may vary with the nature of each member varies, though typically the distance is generally between 2 and 4cm, for example, 3cm.

[0058] 贴片探头28(patchprobe28)可W用任何适合的材料制造,所述材料适合于支持其中所包含的电子/光学部件,例如光源、光探测器、光纤或镜,并且适合于放置在皮肤上。 [0058] The patch probe 28 (patchprobe28) W can be any suitable material, said material is adapted to support the electronic / optical components contained therein, for example, a light source, a light detector, a mirror or an optical fiber, and adapted to be placed on the skin. 运种适合的材料的一个实例是医用橡胶。 One example of suitable types of transport materials are medical rubber. 贴片28可W手动固定位置,可W通过粘合剂固定位置(贴片的一侧可W涂覆有对皮肤有粘性的材料例如水凝胶粘合剂),或者可W适于用带子固定位置,所述带子能够系紧或通过其他方式固定。 Patch 28 may be manually fixed position W, W may be a fixed position by means of an adhesive (W side of the patch may be coated with a viscous material such as a hydrogel skin adhesives), or may be adapted with tape W a fixed position, the strap can be fastened or secured by other means. 带子的另一端也可W包含粘合材料例如Velcro,W便于它们的连接并使装置固定位置。 The other end of the strap may comprise an adhesive material such as W Velcro, W and connected to means to facilitate their fixing position.

[0059] 光探测器30将接收的反射/透射光转换为可记录的输出例如电流或电压。 [0059] The photodetector 30 receives the reflected / transmitted light into an output current or voltage, for example, may be recorded. 适用于本发明装置的光探测器30的一个实例是娃光电二极管(例如HamamatsuS8553)。 One example of the light detector 30 suitable for use in the present invention means that the baby photodiode (e.g. HamamatsuS8553). 如果需要的话,其中可W包括聚光透镜,W重新聚焦要被光探测器30接收的反射或透射光线。 If desired, which may include a condenser lens W, W to be refocused 30 receives reflected light or transmitted light detector. 如本领域技术人员将会理解的,娃光电二极管是半导体光传感器,当半导体中的PN结受到光照射的时候产生电流或电压。 As those skilled in the art will appreciate, baby photodiode is a semiconductor light sensor, when the PN junction of the semiconductor is irradiated by light generates a current or voltage. 相应地,光探测器30响应接收的光信号提供电流/电压信号。 Accordingly, the optical signal received by the photodetector 30 in response provides a current / voltage signal. 因此,由光探测器30产生的电流/电压信号输出与光探测器30接收的光信号的瞬时光强度成比例。 Therefore, the instantaneous light signal proportional to the intensity of light current / voltage signal output by the photodetector 30. The photodetector 30 receives the generated. 相应地,光探测器30提供随时间变化的输出(例如作为时间函数的电流/ 电压),其依赖于所接收的光及其特性。 Accordingly, photodetector 30 provides an output over time (e.g., as a function of time, current / voltage), depending on the characteristics and the received light. W60] 在本发明的一个方面,提供了一种系统,例如图5、8或16所示,其中装置10的光探测器30与信号处理装置40相连。 W60] In one aspect of the present invention, there is provided a system, such as shown in FIG. 5, 8 or 16, wherein the light detector 30 is connected to the signal processing means 10 to 40. 信号处理装置40可W被操作W接收由光探测器30提供的信号(例如随时间变化的电流/电压信号)并将信号转换为可视输出例如波形。 The signal processing device 40 may be operated W W received signal (e.g. time-varying current / voltage signal) and converts the signal into a visual output such as waveform 30 provided by a light detector. 因此, 信号处理装置40可W被操作使光探测器30提供的输出数字化,成为可记录的输出,W显示在显示器(例如44)上。 Thus, the signal processing device 40 may be operated so that the output W digitized photodetector 30 provides, as an output can be recorded, displayed on the display W (e.g. 44).

[0061] 参考图5或8,提供了一种系统,其包括:至少一个光源20,其用于发射光;探头28,其有利于光向患者外部组织部位传送;至少一个光探测器30,其被配置W接收由光源20发射的光(其由组织部位反射而来或者透射穿过组织部位)并响应光将其转换为电流/ 电压信号;信号处理装置40,其将来自光探测器30的信号转换为可视输出例如随时间变化的波形。 [0061] Referring to FIG 5, or 8, there is provided a system, comprising: at least one light source 20 for emitting light; probe 28, which is conducive to tissue of a patient to an external light transmission portion; at least one light detector 30, W which is configured to receive light emitted by the light source 20 (which is reflected by or transmitted through the tissue site from the tissue site) in response to light and converts it to a current / voltage signal; the signal processing device 40 from the light detector 30 signal into a visual output, for example, time varying waveform. 如下文将要描述的,信号处理装置40可W包括:微处理器(例如数字信号处理器, TexasInstruments)或数据采集卡42,W将来自光探测器30的信号(例如电流/电压) 数字化;和显示单元44,例如显示器,其与微处理器42通讯或与之连接(图5),其作用是W 波形的形式显示信号。 As will be described, the signal processing device 40 may include W: a microprocessor (e.g., a digital signal processor, TexasInstruments) or data acquisition card 42 is, W signal from the light detector 30 (e.g., current / voltage) digitizing; and a display unit 44, such as a display, or communications with the microprocessor 42 attached thereto (FIG. 5), whose role is to form a display signal waveform W.

[0062] 或者,如本领域技术人员将会理解的W及如图5B所示,信号处理装置40可W与显示单元44分隔开,并与外部显示单元44通讯,用于在其上显示信号处理装置40的输出。 [0062] Alternatively, as those skilled in the art will appreciate that the W and 5B, the signal processing device 40 and the display unit W may be separated by 44, 44 and the communication unit and an external display, for displaying thereon output signal processing means 40. 为方便起见,显示单元,例如显示器,可W是便携的,例如手持单元、和/或电池供电的。 For convenience, a display unit, such as a display, W can be portable, such as a handheld unit, and / or battery powered. 运种手持单元可W通过电缆与包括光源和光探测器的贴片探头28相连。 W may be transported species handheld unit is connected by a cable to the patch probe comprises a light source and a light detector 28. 该系统可W进一步包括用于插接手持显示器并给其充电的插接站(dockingstation),或者用于探头28的插接站,其任选地包括适于校准探头的单元。 The system may further comprise a W plug to the hand-held monitor and a docking station (dockingstation) charging thereof, or a probe for the docking station 28, optionally comprising means adapted to calibrate the probe.

[0063] 根据另一个实施方案,信号处理装置40可W进一步包括算法处理模块41(例如图8中所示的),用于接收所需屯、脏参数输出的指令(例如通过用户界面或所需屯、脏参数的预定义选项)。 [0063] According to another embodiment, the signal processing device 40 may further include an algorithm W processing module 41 (e.g. as shown in FIG. 8), for receiving Tun, instructions dirty desired output parameters (e.g., via the user interface or the Tuen required, predefined options dirty parameters). 算法处理模块41可W被操作W将从光探测器30接收的信号转换为所需的屯、 脏参数输出(例如血压波形)。 W algorithm processing module 41 may be converted operation signal W received from the photodetector 30 is required Tun, dirty output parameters (e.g. blood pressure waveform).

[0064] 参考图16,信号处理装置40可W在一个或多个单独的计算装置101上实现。 [0064] Referring to FIG 16, the signal processing device 40 W may be implemented on one or more separate computing device 101. 装置101通常可W包括网络连接接口200,例如网络接口卡或调制解调器,其通过线路218与装置基础结构204禪联。 W apparatus 101 may generally include a network connection interface 200, a network interface card or a modem, by line 218 with the base structure 204 associated means Zen. 在装置101的操作过程中,连接接口200可与网络11(例如内联网和/或外联网例如因特网)连接,使得装置101彼此适当地通讯。 During operation of the apparatus 101, the interface 200 may be connected to a network 11 (e.g. an intranet and / or an extranet such as the Internet) is connected, so that the device 101 suitably communicate with each other. 网络11可W,例如,支持光探测器30提供的输出信号(例如电流/电压信号)与信号处理装置40的通讯。 Network 11 may be W, e.g., to support the output signal of the photodetector 30 to provide communication (e.g., a current / voltage signal) and the signal processing device 40. 阳0化]装置101还可W具有用户界面202,也如图16所示,其通过线路222与装置基础结构204禪联,W与用户交互。 Of male 0] W device 101 may also have a user interface 202, as shown in FIG 16, which through a line 222 with the base structure 204 linking means Chan, W interact with the user. 用户界面202可W包括一个或多个用户输入装置,例如但不限于,QWERTY键盘、袖珍键盘、滚轮、触控笔、鼠标、麦克风和用户输出装置例如LCD屏幕显示器和/或扬声器。 W user interface 202 may include one or more user input devices such as, but not limited to, QWERTY,, keypad, scroll wheel, a stylus, a mouse, a microphone and the user output device such as an LCD screen display and / or speakers. 如果屏幕是触摸感应的,那么显示器也可W被用作用户输入装置,由装置基础结构204控制。 If the screen is touch sensitive, then the display can also be used as a user input device W, the control device 204 by the infrastructure.

[0066] 装置101的操作通过装置基础结构204(deviceinfrast;ruc1:ure204)得W方便地实现。 Operation [0066] The apparatus 101 through the device infrastructure 204;: W obtained easily implemented (deviceinfrast ruc1 ure204). 装置基础结构204包括一个或多个计算机处理器208 (例如数字信号处理器),并且可W包括关联存储器210 (例如随机存取存储器)。 Device infrastructure 204 includes one or more computer processors 208 (e.g., a digital signal processor), and may include an associated memory 210 W (e.g., random access memory). 计算机处理器208帮助提高计算装置101的性能,所述计算装置101被配置W通过执行任务相关指令来操作网络接口200、用户界面202和计算装置101的其他应用程序/硬件207,从而完成既定任务。 To help improve performance of the computer processor 208 of computing device 101, the computing device 101 is configured to W by executing task related instructions network interface 200, user interface 202 and the computing device 101 other application programs / hardware 207 to perform a given task . 运些任务相关指令可W由操作系统和/或位于存储器210中的软件应用207提供,和/或由被配置到处理器208的电子/数字电路中的操作提供,其中所述处理器208被设计用W执行特定任务。 These task related instructions can be transported W provided by the operating system and / or in the memory 210 of the software applications 207, and / or provided by the processor is configured to electronic / digital circuitry 208 in operation, wherein the processor 208 is designed to perform specific tasks with W. 进一步,应当认识到装置基础结构204可W包括与处理器208禪联的计算机可读存储介质212,用于向处理器208提供指令。 Further, it should be appreciated that the device infrastructure 204 W may comprise a computer-readable storage medium associated with the processor 208 Zen 212 for providing instructions to processor 208. 计算机可读介质212可W包括硬件和/或软件,例如,仅W举例的方式,磁盘、磁带、任选地可读介质例如CD/DVDROMS、和存储卡。 The computer-readable medium 212 W may include hardware and / or software, e.g., by way of example only W, a magnetic disk, magnetic tape, optionally readable medium such as CD / DVDROMS, and the memory card. 在每一种情况下,计算机可读介质212可W采用小磁盘、软盘、盒式磁带、硬盘驱动器、固态存储卡或存储模块210中提供的RAM的形式。 In each case, the computer readable medium 212 may take the form of RAM W small disk, diskette, cassette, hard disk drive, solid state memory card, or memory module 210 is provided. 应当注意的是,上述列举的计算机可读介质212的实例可W单独使用或组合使用。 It should be noted that the above listed example computer-readable media 212 W may be used alone or in combination. 装置存储器210和/或计算机可读介质212可用于储存,例如, 所需的输出(例如压力波形),W用于处理从光探测器30接收的信号。 The memory device 210 and / or computer-readable storage medium 212 may be used, for example, the desired output (e.g., a pressure waveform), W for processing signals received from the light detector 30.

[0067] 进一步,应当认识到计算装置101可W包括可执行应用207,其包含代码或机器可读指令,用于实现预定的功能/操作,包括操作系统的那些。 [0067] Further, it should be appreciated that executable application 207, comprising code or machine readable instructions for implementing predetermined functions / operations, including an operating system of computing device 101 may comprise W. 此处使用的处理器208是配置的装置和/或机器可读指令集,用于执行上述实例所述的操作。 Used herein means the processor 208 is configured and / or set of machine-readable instructions for performing operations according to the above examples. 如本文所使用的,处理器208可W包含硬件、固件、和/或软件的任何一种或其组合。 As used herein, W processor 208 may include hardware, firmware, any one or a combination, and / or software. 处理器208通过操作、分析、修改、转换或传递信息,使其为可执行程序或信息装置所用,和/或通过相对于输出装置路由信息,而对信息发生作用。 Processor 208 by manipulating, analyzing, modifying, converting or transmitting information, it is an executable procedure or an information device used, and / or by routing the information with respect to the output means, the action of the information occurs. 例如,处理器208可W使用控制器或微处理器或包含它们的功能。 For example, processor 208 may use a controller or microprocessor or W comprise their function. 相应地,信息处理装置40和/或光探测器30的功能可W在硬件、软件或二者的组合上实现。 Accordingly, the information processing apparatus 40 and / or the function of the light detector 30 may be implemented on the W combination of hardware, software, or both. 相应地,为了简单起见,处理器208作为装置和/或作为机器可读指令集的应用W下统称为处理器/模块。 Accordingly, for simplicity, collectively referred to as the device processor 208 and / or as machine-readable instructions for the processor application W / module.

[0068] 应当理解,计算装置101可W是,例如,个人计算机、个人数字助理、移动电话、和内容播放器。 [0068] It should be understood that W is a computing device 101 may, for example, a personal computer, a personal digital assistant, a mobile phone, and a content player. 进一步,应当认识到每个服务器计算装置101,虽然被描述为单机系统,如有需要,可W作为计算机处理器网络实现。 Further, it should be appreciated that each server computing device 101, although described as a stand-alone system, if necessary, W may be implemented as a network of computer processors.

[0069] 参考图8,信号处理装置40可W执行算法(例如通过算法处理模块41)W将光探测器30接收的信号转换为波形。 [0069] Referring to Figure 8, the signal processing device 40 may execute an algorithm W (e.g. by arithmetic processing module 41) converts the signal W of the light detector 30 is received waveform. 波形是与屯、脏活动相关的光信号随时间变化的成分,其可W被转换为动态信息例如血流、流速、血量、血压和血液成分例如血氧或血管中血液的物理移位。 Waveform of the optical signal is related to the village, dirty active ingredient over time, which can be converted into W dynamic information, for example, blood flow rate, blood volume, blood pressure, blood oxygen and blood components such as blood vessels or physical displacement.

[0070] 在一个实施方案中,例如,信号被转换为压力波形(pressurewave化rm)。 [0070] In one embodiment, for example, the pressure waveform signal is converted into (pressurewave of rm). 由于中屯、静脉压力波形与颈静脉内的血量成比例,而来自光探测器的接收信号(例如电流/电压信号)的幅值与血量成反比例,因此通过下述的光探测器接收信号转换算法构建中屯、静脉压力波形: Since the village, and venous blood pressure waveform is proportional in the jugular vein, and the received signal from the photodetector (e.g., a current / voltage signal) is inversely proportional to the magnitude of the blood, thus following the reception by the light detector Construction Tun signal conversion algorithm, venous pressure waveform:

[0071]P(t)~1/S(t) [0071] P (t) ~ 1 / S (t)

[0072] 其中P是压力波形,S是来自光探测器的信号(例如电流/电压信号)。 [0072] where P is the pressure waveform, S is a signal (e.g., current / voltage signal) from the photodetector.

[0073] W用户确定的间隔,例如10个数据点/mm,收集的吸收值被储存为与屯、脏参数或屯、输出量相关的电子表格。 [0073] W interval determined by the user, such as absorption value of 10 data points / mm, and the collection is stored as Tun, Tun dirty or parameters, the output of the associated spreadsheet. 显示单元44实时运行W显示选定血管相对于时间的波形,所述波形根据执行的算法获得(通过算法处理模块41),其可用于计算例如屯、脏参数或屯、输出量,如下所述,。 The display unit 44 displays real-time operation W vascular phase waveform to the selected time, said waveform is obtained (by the arithmetic processing module 41), which can be used to calculate e.g. Tun, Tun dirty or parameters, the output of an algorithm executed as follows .

[0074] 通过本发明装置获得的波形(例如根据光探测器获得的信号产生并由信号处理装置40处理)的显示实例如图4所示。 Shows an example of [0074] (e.g. generated based on the signal obtained from the photodetector 40 by the signal processing means processing) obtained by the apparatus of the present invention, the waveform is shown in FIG. 可W看出,在光探测器30检测到的信号中存在时间进程变化,其是由选定血管的搏动、血管内血量和血液成分(例如氧饱和度)的变化导致的。 W can be seen, the time course of changes in the presence of a signal detected by the photodetector 30, which is by pulse, blood vessels and blood components within selected vessels (e.g., oxygen saturation) caused by a change. 选定血管中的血量和血液成分影响光的吸收,由此导致具有变化幅值的信号。 Selected blood vessels and blood components affect the absorption of light, thereby resulting in a signal with varying amplitude. 例如,随着颈静脉搏动增加和减少,颈静脉中的血量、检测的光信号(例如被光探测器30接收)的幅值将会分别减小和增大。 For example, with the increase and decrease JVP, amplitude output, an optical signal detected in the jugular vein (e.g., the light receiving sensor 30) will decrease and increase, respectively. 所记录信号的幅值的时间进程图反映了颈静脉搏动的波形。 Time course of the amplitude of the recorded signal diagram reflects the JVP waveform.

[00巧]在本发明的另一个实施方案中,提供了装置100,其可W被操作W测量血液成分, 例如中屯、静脉血的血氧饱和度。 [Qiao 00] In another embodiment of the present invention, there is provided an apparatus 100, which can be operated W W measure blood component, in the village, for example, venous blood oxygen saturation. 由于颈静脉,尤其是右颈内静脉,直接与上腔静脉相连,如图1所示,因此颈静脉波形代表着中屯、静脉血的参数。 Since the jugular vein, particularly the right internal jugular vein, superior vena cava directly connected, as shown in Figure 1, so the waveform represents the jugular vein Tun, the parameters of venous blood.

[0076] 为此,装置100,如图7和8所示,包括至少两个光源120,每个发射400nm至lOOOnm 范围内的不同波长的光。 [0076] For this purpose, the apparatus 100, shown in Figures 7 and 8, comprising at least two light sources 120, each emitting light of different wavelengths in the range 400nm to lOOOnm. 该装置还包括对应于每个光源120的光探测器130,其适于接收特定波长的透射光或反射光。 The apparatus further comprises a light detector corresponding to each of the light sources 130,120, which is adapted for receiving transmitted light or reflected light of a particular wavelength. 如上文所述,每个光发送部件(例如光源120或发送光纤124) 和光接收部件(例如光探测器130或接收光纤126)被设置在贴片探头128中,并且可W如图7A或7B所示排列;然而,如本领域技术人员所知,光发送部件和光接收部件存在替代的排列方式,而不会影响装置100的功能。 As described above, each optical transmission member (e.g. transmission fiber 124 or the light source 120) and the light receiving member (e.g., a light detector receiving the optical fiber 130 or 126) is provided in the patch probe 128, and may be W in FIG. 7A or 7B the arrangement shown; however, as those skilled in the art, the presence of the light transmitting member and the light receiving member of an alternative arrangement, without affecting the function of the device 100. 例如,装置100可W包括多个贴片探头128,其中每个都包括光发送部件和光接收部件。 For example, device 100 may comprise a plurality of patches W probes 128, each of which includes a light transmitting section and a light receiving member. 或者,装置100可W包括单个贴片128,其包括多个光发送部件和光接收部件。 Alternatively, the device 100 may comprise a single patch 128 W, comprising a plurality of light-transmitting member and the light receiving member. 在另一种替代方式中,装置100可W包括具有一个或多个光发送部件和光接收部件的第一贴片128,和具有一个或多个光发送部件和相应的光接收部件的第二贴片。 In another alternative embodiment, W device 100 may comprise one or more first patches having the light transmitting member and the light receiving member 128, and a second paste having one or more light transmitting members and the respective light-receiving member sheet. 如上文所述,不管贴片的数量及其排布方式如何,该装置可W被包括在上述的系统中,所述系统包括信号接收装置140 W将光探测器130的输出转换为,例如,所期望的形式。 As described above, regardless of the number and the arranging manner of the patch, the apparatus W may be included in the above system, the system comprising signal receiving means 140 W output of the photodetector 130 is converted, for example, the desired form.

[0077] 在不同波长的与屯、脏血管搏动相关的检测信号中的时间进程变化可用于计算血液成分,例如血氧饱和度,W及其他与屯、脏血管搏动相关的参数。 [0077] The time course of changes in the correlation detection signal and Tun, dirty pulsatility different wavelengths can be used to calculate a blood component, such as oxygen saturation, W, and other related Tun, dirty pulsatility parameters. 存在多种方法根据屯、脏血管搏动引起的在多种光波长,例如780nm和850nm的检测信号变化来计算血氧饱和度。 There are various method Tun, multiple wavelengths of light caused by vascular pulsation dirty, the detection signal change, for example, 780nm and 850nm to calculate oxygen saturation. 如本领域技术人员所知,所选择的用于确定血液成分的波长随待确定的血液参数的不同而不同。 As those skilled in the art, various different blood parameter for determining the blood component with a selected wavelength to be determined. 例如,690皿和830皿的波长,分别可用于获得脱氧血红蛋白和氧合血红蛋白含量。 For example, a wavelength of 690 dishes and dish 830, respectively, may be used to oxygenated hemoglobin and deoxygenated hemoglobin obtained. 950nm的波长可用于获得血液水分含量。 950nm wavelength may be used to obtain the moisture content of the blood. 而且,感兴趣的血液参数可W通过如下所述的光子扩散方程、光子运输方程或修正的比尔朗伯定律(ModifiedBeerLambert'SLaw)确定。 Further, the blood parameters of interest can be determined by photon diffusion equation W follows the photon transport equation or amended Beer-Lambert law (ModifiedBeerLambert'SLaw).

[0078]修巿的比尔郎伯定律 [0078] Beer Lambert's law of the repair market

[0079] 检测的信号(例如电流)可W表示为: [0079] The detection signal (e.g., current) can be expressed as W:

[0080] [0080]

Figure CN105163662AD00111

阳0川其中: Yang Chuan 0 of which:

[00間/乂I是波长A1的由光探测器提供的信号, 阳08;3] /〇,4是波长入1的来自光源的信号, [00 / qe I A1 is the wavelength of the signal provided by the photodetector, 08 male; 3] / square, the 4 wavelength signal from the light source 1,

[0084] Cwb,Cwb。 [0084] Cwb, Cwb. 是稳定组织介质血液的脱氧和氧合血红蛋白浓度; It is stabilized deoxygenated hemoglobin and oxygenated blood tissue medium;

[00财ACwb,ACwb。 [00 fiscal ACwb, ACwb. 是颈静脉搏动引起的脱氧和氧合血红蛋白浓度变化; Change is the concentration of oxyhemoglobin and deoxygenated JVP caused;

[0086] f雜,為,6谢〇.^1是脱氧和氧合血红蛋白在波长A1的吸收特性,其目的是计算血氧饱和度;W及 [0086] f heteroaryl as, 1 ^ 6 XIE square is deoxygenated and the oxygenated hemoglobin absorption characteristics in a wavelength A1, its purpose is to calculate oxygen saturation;. W and

[0087] AB是由边界条件确定的常数。 [0087] AB are constants determined by the boundary conditions.

[0088] 对于第一波长,由颈静脉搏动引起的由光源发射信号到光探测器检测信号的信号相对变化由下式表示: [0088] For the first wavelength, due to the JVP signal emitted from the light source to the light detector signal corresponding to the detection signal changes represented by the following formula:

Figure CN105163662AD00121

[0096] 使用时,包含光源20和光探测器30的装置10的贴片探头28通常被放置在患者的脖子上靠近选定血管,例如颈内静脉的部位。 [0096] In use, the light detector comprising a light source 20 and the patch 10 of probe apparatus 30 28 placed on the neck is typically close to the patient's blood vessels selected, for example, the portion of the internal jugular vein. 理想的是患者与水平倾斜约30度角平躺。 Patients and desirable horizontal tilt angle of about 30 degrees lying. 在测量血管搏动,例如血管中血量的过程中,患者保持规律呼吸。 Vascular pulsation measuring, for example, during blood vessel, the patient maintain regular breathing. 来自光源20的光被患者脖子上的祀部位反射或者透射穿过该部位,并被光探测器30检测。 From the light source 20 is reflected worship site on a patient or transmitted through the neck portion, detected by the light detector 30. 光探测器30将检测到的光转换为输出信号(例如电流/电压),所述输出信号可W被数字化W表示为随时间变化的幅值,W得到选定血管搏动的波形。 Light detector 30 converts the detected light into an output signal (e.g. current / voltage), the output signal may be represented W W is digitized time-varying amplitude, a waveform W is selected pulsatility. 根据上述的朗伯定律,使用不同波长获得的波形幅值可用于确定血氧。 According to the Lambert's law, the amplitude of the waveform can be obtained using different wavelengths for determining the blood oxygen.

[0097] 由于器官组织,例如脖组织,通常是异质性的,因此它对近红外光表现出不同的衰减效应(attenuationeffects)。 [0097] As the organ tissue, such as neck tissue, usually heterogeneous, so it near-infrared light exhibit different attenuation effects (attenuationeffects). 因此,患者脖子上的不同部位,或者不同患者的脖组织,可能导致搏动信号幅值有不希望的差异,由此产生对例如静脉血氧的不准确测定。 Thus, different parts of the neck of the patient, or the neck tissue of different patients, may lead to unwanted beat signal amplitude difference, thereby generating, for example, do not accurately determine the venous oxygen. 运意味着周围组织对颈静脉的衰减效应不能被认为是常数,因此静脉血氧的计算必须被校正W适应运些衰减差异。 Transport means surrounding tissue attenuation effects jugular vein can not be considered to be constant, the calculation must be corrected venous oxygen transport W accommodate some attenuation differences.

[0098] 此处还提供了衰减校正装置400,其用于确定静脉血氧,该静脉血氧针对运种衰减差异而被校正,如图19所示。 [0098] Also provided herein attenuation correction means 400 for determining venous oxygen, venous oxygen difference in attenuation for the transported species is corrected, as shown in Fig. 装置400包括至少一个光源巧1)410,其能够发射400皿至lOOOnm波长范围内的两种不同波长的光。 At least one light source device 400 includes Qiao 1) 410, the light of two different wavelengths of the dish 400 to lOOOnm wavelength range can be emitted. 所使用的适合的波长对的实例包括,但不限于, (wl是660nm,w2 是880nm)、(wl是660nm,w2 是905nm)W及(wl是660nm,w2 是940nm)。 Examples of suitable wavelength to be used include, but are not limited to, (WL is 660nm, w2 is 880nm), (wl is 660nm, w2 is 905nm) W and (WL is 660nm, w2 is 940nm). 装置400还包括至少一个光探测器值1)420,其能够检测光源发射的两种不同波长的光。 Apparatus 400 further comprises at least one light detector value 1) 420 capable of detecting light of two different wavelengths of light emitted. 因此,该装置可W包括一个光源和两个光探测器(图19A/C/巧、两个光源和一个光探测器(图19B/D/E)、或两个光源和两个光探测器(图19G/H/I)。每个光源和光探测器之间的距离必须是不同的(至少差大约1mm),光源和光探测器之间的距离在大约0.5cm至大约10cm之间。装置400还包括贴片探头,与上述的贴片探头28类似,其允许/有利于光源发射的光向选定的患者部位的传送和患者部位反射的或透射穿过患者部位的光向光探测器的传送。 Thus, the apparatus may comprise a light source W and two photodetectors (FIG. 19A / C / coincidence, two light sources and a photodetector (FIG. 19B / D / E), or both of the two light sources and photodetectors (FIG. 19G / H / I). the distance between each light source and the light detector must be different (difference of at least about 1mm) the distance between the light source and the light detector, between about 0.5cm to about 10cm. means 400 the probe further comprising a patch, similar to the above patch probe 28, which allow / facilitate light emitted from the light reflected to the transmission site and the patient or the selected patient locations light transmitted through the patient locations of the light detector transfer.

[0099]使用图19A所示的装置,例如,连续地,第一波长的光从光源或光发射器UE1)发射,并被光探测器1值1)检测,记录为leiDi,并且,连续地,第二波长的光从E1发射并被光探测器2值2)检测,记录为IeiD2。 Means [0099] FIG. 19A, for example, continuously, a first wavelength of light from the light source or light emitter UE1) emitted by the light detector a value of 1) detection, recorded as Leidi, and continuously , from the second wavelength of light emitted by the light detector binary E1 2) is detected, the recording is IeiD2. E1和D1之间的距离与E1和D2之间的距离不同。 The distance between E1 and D1 and D2 and the distance between the different E1. 每个记录的光信号具有血液搏动引起的AC部分和包括血管在内的整个组织介质引起的DC部分。 Each optical signal recording portion having AC and DC component across tissue, including blood vessels caused by blood pulsation caused by the medium. 通过比较一段时间中经由不同光源(或发射器)和探测器对测量的平均光强度值C)(反映了稳定组织介质的性质-当没有搏动时DC是常数),获得在给定波长,W,的光衰减(0D)。 By comparing the period of time via different source (or emitter) and a light detector on the average intensity value measured C) (reflecting stable tissue medium - if no pulsation DC is a constant), obtained at a given wavelength, W , light attenuation (0D). 在特定波长,W,的光衰减可W按下式计算: In a particular wavelength, W, of the light attenuation can be calculated as W:

Figure CN105163662AD00131

[0103] 通过比较两种不同波长的0D获得两种波长,wl和之间的光衰减差异的衰减校正系数似: 阳104] [0103] 0D obtained by comparison of two different wavelengths of two wavelengths, the attenuation of light attenuation correction coefficient and the difference between similar wl: male 104]

Figure CN105163662AD00132

[01化]该校正系数可用于校正静脉血氧的测定。 [Of 01] correction coefficient may be used to determine the venous oxygen correction. 当组织氧合或当静脉血氧变化时,C是可变的。 When tissue oxygenation or when changes venous oxygen, C is variable.

[0106] 在一个实施方案中,衰减校正装置400本身可用于测定静脉血氧,其依据的是下述的标准血氧计方程式: 阳1〇7] S jv〇2(未校正)=A+B*R 阳108]其中R = (AC/DC) (AC/DC)心并且 [0106] In one embodiment, attenuation correction device 400 may be used to determine the venous oxygen itself, which is based on the following standard oximeter equation: male 1〇7] S jv〇2 (uncorrected) = A + B * R male 108] where R = (AC / DC) (AC / DC) and heart

[0109] A和B是通过标准脉搏血氧计校准程序(本领域中已很成熟)确定的常数,包含衰减校正系数,C,如下所示: 阳110] S jv〇2(校正)=A+B*(C*R) 阳111] 或者,衰减校正装置400可W用于系统中,所述系统包括:与信号处理装置40相连的光学装置10W确定静脉血氧,和也与信号处理装置40相连的装置400W确定衰减校正。 [0109] A and B by standard pulse oximeter calibration procedure (in the present art is mature) constant determined comprising attenuation correction coefficient, C, is as follows: male 110] S jv〇2 (corrected) = A + B * (C * R) male 111] Alternatively, W may be the attenuation correction apparatus 400 used in the system, the system comprising: determining venous oxygen 10W connected to the optical device 40 a signal processing apparatus, signal processing apparatus, and also 400W determining means 40 is connected to the attenuation correction. 信号处理装置40可W被操作W接收由光学装置10的光探测器和装置400的光探测器提供的信号,转换由此得到的信号,并执行算法计算测量的静脉氧合、衰减校正和校正的静脉氧合。 The signal processing device 40 may be operated W W received optical signal provided by the photodetector and the photodetector means 400 of the apparatus 10 a signal, whereby the conversion, and performs algorithm venous oxygenation measurement, correction and attenuation correction venous oxygenation. 可用于确定静脉血氧的光学装置10的实例如图1A、图13和图14所示。 Examples of the optical device shown in FIG 1A may be used to determine venous oxygen 10, 13 and 14 shown in FIG. 系统可W如图5或6所示,其另外包括与信号处理装置通讯的衰减校正装置400。 W system shown in FIG. 5 or 6, further comprising signal processing means to communicate with the attenuation correction means 400.

[0112] 除上文所述之外,衰减校正装置400可W与其它装置一起用于确定静脉血氧,例如传统的脉搏血氧计。 [0112] In addition to the above, attenuation correction device 400 may determine venous oxygen W together with the other devices, such as a conventional pulse oximeter.

[0113] 在另一个实施方案中,如图9(AC)所示,提供了装置200,其包括一个或多个光源220,每个光源发射400nm至lOOOnm范围内的选定波长的光。 [0113] In another embodiment, illustrated in Figure 9 (AC), the apparatus 200 is provided, which comprises one or more light sources 220, each light source emits light within a selected wavelength range of 400nm to lOOOnm. 每个光源220与至少两个光探测器230禪联,每个光探测器适合于接收W给定频率发射的光。 Each of the at least two light source 220 light detector 230 associated with Zen, each photodetector adapted for receiving light emitted from the W given frequency. 如上文所讨论的,装置200 任选地可W被包括在系统中,例如如图5所示。 As discussed above, the apparatus 200 W may optionally be included in the system, for example as shown in FIG.

[0114] 装置200可用于同时测量多个屯、脏血管搏动,例如颈静脉搏动和颈动脉搏动,由此产生双波形,如图10所示,并且因此可用于在如上所述地测量中屯、静脉氧合,S,成2,之外, 同时测量动脉血氧,8。 [0114] device 200 may be used to simultaneously measure a plurality Tun, vascular pulsation dirty, e.g. JVP and carotid pulse, thereby generating a double wave, shown in Figure 10, and thus can be used in the measurement as described above Tun , venous oxygenation, S, into two, addition, simultaneous measurement of arterial oxygen, 8. 〇2。 〇2. 如本领域技术人员所知,在存在多个光源220的情况下,每个光源依次打开,并且从光源发射的光的幅值在选定的频率,例如10曲Z或20曲Z被调制。 As those skilled in the art, in a case where there are a plurality of light sources 220, each light source are sequentially turned on, and the amplitude of the light emitted from the light source at a selected frequency, for example, Z 10 or Z 20 is modulated. 或者从单个光源220发射的光可W在两个交替的频率,例如10曲Z或20曲Z被顺序调制。 Or emitted from a single light source may be 220 W in two alternate frequencies, such as Z 10 or Z 20 are sequentially modulated. 来自光探测器的输出(例如电流/电压)在选定的频率被过滤,例如通过带通滤波器进行过滤, 所述选定的频率与光源发射的特定频率相关联,所述带通滤波器允许选定频率,例如10曲Z 或20曲Z的信号通过,但阻止信号中其它频率成分。 The output from the photodetector (e.g., a current / voltage) is filtered in a selected frequency, for example, by filtration through a bandpass filter, the frequency of the selected light source emitting a particular frequency associated with the bandpass filter allow a selected frequency, e.g. 10 or Z 20 Z signal is passed through, but prevents the other frequency component of the signal.

[0115] 在另一个实施方案中,提供了测量中屯、静脉压的方法。 [0115] In another embodiment, there is provided a method of measuring Tun, venous pressure. 中屯、静脉压是靠近右屯、房的腔静脉的压力。 In Tun, Tun venous pressure is near the right atrial pressure vena cava. 异常高的中屯、静脉压是右屯、房屯、力衰竭的早期指征。 Tuen abnormally high, is a right venous pressure Tun, Tun room, an early indication of failure force. 目前,通过穿过颈内静脉插入至腔静脉的侵入性导管测量中屯、静脉压。 Currently, inserted into the vena cava via the jugular vein through the catheter invasive measurement Tun, venous pressure.

[0116] 提供了测量患者中屯、静脉血压的方法,其依据是颈静脉搏动的垂直高度,例如颈静脉内血液的高度直接反映中屯、静脉压。 [0116] Providing the patient Tun measurement, venous pressure method, which is based on JVP vertical height, for example, a direct reflection of the height of the internal jugular vein in the blood Tun, venous pressure. 颈静脉上存在压力波的最高位置的确定提供了信息,该信息可W用于计算中屯、静脉血压。 Determining the presence of the highest position on the jugular vein pressure wave provides information that can be used in the calculation W Tun, venous pressure. 因此,该方法包括沿着颈静脉确定产生波形的最高位置的步骤。 Thus, the method includes determining the highest position along the jugular vein to produce a step waveform. 可W由已知的参考点测量所述"最高位置",参考点例如距右屯、房为已知距离的点例如胸骨角(sternalangle)或静脉静止轴(phlebostaticaxis)。 W can be measured by a known reference point of the "uppermost position", the right from the reference point Tun e.g., housing for a known distance, for example, the sternal angle point (sternalangle) or intravenous stationary shaft (phlebostaticaxis). 胸骨角是胸骨柄和胸骨体相接形成的角,其形式为次级软骨关节(联合)。 Sternal angle is the angle of the manubrium sternum and the contact is formed, articular cartilage in the form of a secondary (combined). 其也被称为胸骨柄胸骨关节(manubriosternaljoint)或Louis角。 Which it is also known as the sternum joint (manubriosternaljoint) or Louis angle. 静脉静止轴(phlebostaticaxis)位于第四肋间隙和胸前后(A巧径1/2处,并且靠近右屯、房的位置。 After intravenous stationary shaft (phlebostaticaxis) in the fourth intercostal space and the chest (A clever at 1/2 diameter, and near the right Tun, room location.

[0117] 波形的获得是通过W下实现的:将波长在400nm至lOOOnm范围的光线对准靠近颈静脉的患者外部组织部位,检测由组织部位反射的或透射穿过组织部位的光,并将检测到的光转换为相对于时间的输出信号W产生波形。 [0117] obtained by the waveform W is realized: the wavelength of the alignment external jugular vein tissue of a patient near the site of the light 400nm to lOOOnm range, by detecting the reflected light transmitted through the tissue site or tissue site, and converting the detected light into an output signal W with respect to time to generate waveforms. 当次最高位置未产生波形时,沿着颈静脉确定产生波形的最高位置。 When the next highest position is not generated waveform, determined along the jugular vein to produce the highest position of the waveform.

[0118] 中屯、静脉压(巧是基于右屯、房至颈静脉搏动高度的垂直距离(cU,也就是说,最高位置,即P=dy。如果参考点是胸骨角,平均中屯、静脉压可W按下式计算: 阳119] P=5+d•sin白 [0118] In Tun, venous pressure (based on a right Qiao Tun, JVP room height to the vertical distance (cU, that is, the highest position, i.e., P = dy. If the reference point is a sternal angle, Tun-average, W venous pressure can be calculated as follows: male 119] P = 5 + d • sin white

[0120] 其中d是胸骨角至产生波形的最高位置的距离。 [0120] where d is the distance from the sternal angle to produce the highest position of the waveform. 符号0是患者上身相对于水平位置的倾斜角。 Symbol 0 is the inclination angle of the upper body of the patient with respect to the horizontal position. 加上5cm代表胸骨角到右屯、房的距离。 Plus 5cm on behalf of Tuen the sternal angle to the right, from the room. 如果所使用的参考点是静脉静止轴(phlebostaticaxis)(靠近右屯、房的位置),按下式计算中屯、静脉压: If the reference point used is intravenous stationary shaft (phlebostaticaxis) (near the right Tun, housing position), the following formula Tun, venous pressure:

[0121]P=d•sin白 [0121] P = d • sin White

[0122] 获得屯、脏静脉的波形之后,可W按下式计算中屯、血压:戶= After the [0122] obtained Tun, dirty venous waveform can be calculated as W in Tun, blood pressure: p =

[0123] 其中a是与脖子上传感器位置相关的常数,b是与传感器的源和光探测器之间的距离相关的常数;T是脉宽,t是搏动的平均起落时间。 [0123] wherein a position sensor is associated with the neck of the constant, b is related to the distance between the source and the light detector sensor constant; T is the pulse width, t is the time of rise and fall mean beat.

[0124] 根据测量中屯、静脉压的方法,提供装置300。 [0124] The measuring method Tun, venous pressure, providing means 300. 如图13所示,装置300,包括沿着长度彼此相邻的一系列光源320,其适合于测量屯、脏静脉,例如颈内静脉或颈外静脉中的血水平。 13, apparatus 300, comprises a series of to each other along the length of the adjacent light source 320, which is adapted to measure village, dirty vein, such as blood levels of the external jugular vein or jugular vein. 所述长度通常为1. 5至10cm,每个光源320发射波长为600皿至900皿的光,并与相应的光探测器330相关联,所述光探测器330适合于检测来自其相应光源320的反射或透射光。 The length is usually 1.5 to 10cm, each light source emitting a wavelength of 320 to 600 light boat to boat 900, 330 and the corresponding photodetector associated with the light detector 330 is adapted to detect light from its respective 320 reflected or transmitted light. 装置300另外包括贴片探头328,其作为光源(320)和光探测器(330)之间的接口, 并且适于放置在患者靠近选定屯、脏血管,例如屯、脏静脉的部位。 A probe apparatus 300 further comprises a patch 328, which serves as an interface between the light source (320) and a light detector (330), and adapted to be placed at the site Tun, dirty vein near the selected patient Tun, dirty blood vessels, for example. 探头328可W直接包含光源320和光探测器330,或者可W包含分别与光源和光探测器相连的光发送光纤和光接收光纤,或者可W包括它们的组合,例如光源和光接收光纤,或光发送光纤和光探测器。 Probe 328 may W directly include a light source 320 and photodetectors 330, or may be W comprise respectively a light source and a light detector coupled to the light transmitting fibers and light receiving optical fiber, or may be W including combinations thereof, for example, a light source and a light receiving optical fiber, or an optical transmission fiber and a light detector. 此外, 装置300可W被包括在如前所述的系统中,所述系统包括信号处理装置W将光探测器的输出转换为所希望的形式。 Further, W device 300 may be included in a system as described above, the system includes a signal processing means converts the W light detector output to a desired form.

[0125]使用时,装置300被放置在患者的适合部位,使系列光源的末端光源与胸骨角对齐。 [0125] In use, the device 300 is placed in a suitable site of the patient, so that the end of the light source and the light source is aligned series sternal angle. 来自每个光源的光被其相应的光探测器检测。 Light from each light source is detected its corresponding photodetector. 每个光探测器的输出信号(例如电流/ 电压)被监测(或被发送至信号处理装置W转换为替代的输出形式例如可视波形输出,所述可视波形输出被监测),W确定是否有输出。 An output signal (e.g., current / voltage) is monitored for each light detector (or sent to a signal processing device W output is converted to an alternative form of an output waveform such as a visual, the visual output is monitored waveform), to determine whether W there output. 然后根据序列中每个光探测器的输出确定沿着静脉产生输出,例如波形的最高位置(d)。 The sequence then determines the output of each photodetector produces an output along a vein, for example, the highest position of the waveform (d). 然后可W如上所述计算平均中屯、静脉压(P)。 W can then calculate an average of the village, venous pressure (P) as described above. [01%] 图14显示了可用于如上所述测量中屯、静脉压的装置300的其他实施方案。 [01%] Figure 14 shows other embodiments may be used in the measuring apparatus 300 Tun, venous pressure as described above. 每个实施方案包括光源(一个或多个)和光探测器的不同配置。 Each embodiment comprises a light source (s) and a different configuration of the photodetector. 例如,图14A显示了一种装置, 其包括单个光源和顺序相邻排列在静脉上的一列光探测器,W确定最高位置(d),所述光探测器可用于获得输出,例如波形。 For example, FIG. 14A shows an apparatus which includes a single light source and a sequentially adjacent a photodetector arranged on the veins, W determines the highest position (D), the light detector may be used to obtain an output, such as a wave. 图14B显示了一种装置,其包括W交替方式顺序配置的源-探测器对(源-探测器,源-探测器等),其沿着静脉放置,如所显示的那样。 Figure 14B shows an apparatus comprising a source arranged in order of alternating manner W - detector pair (source - detector, the source - detector, etc.), which is disposed along the vein, such as shown. 图14C示出了与图14B类似的装置,其包括多排交替的源-探测器对。 14C shows a similar device 14B, a plurality of rows comprising alternating source - detector pair. 如本领域技术人员所知,图1 所示的装置还可W用于通过从胸骨角沿静脉向上连续获得波形读数,来确定静脉上产生输出信号(例如波形)的最高位置(d)。 As those skilled in the art, the device shown in Figure 1 can also be obtained by continuous waveform W for reading from the sternal angle up along the vein to determine the vein generates an output signal (e.g., waveform) of the highest position (d). 进一步,如前所述,该装置,无论其如何配置,都可W 被包括在系统中,所述系统包括信号处理装置,W将光探测器的输出转换为可视输出例如压力波形。 Further, as described above, the apparatus, regardless of configuration, W may be included in the system, the system comprising a signal processing means converting the output of the photodetector W is a visual output such as a pressure waveform.

[0127]根据本发明的装置可W另外包括安装在装置328上的角度传感器350,W测量患者上身相对于垂直位置的倾斜角,如图17所示。 [0127] device of the present invention may additionally comprise W device 328 mounted on the angle sensor 350, the upper body of the patient is measured W with respect to the inclination angle in the vertical position, shown in Figure 17. 角度传感器可W是适合于此目的的任何传感器。 W is an angle sensor may be any sensor suitable for this purpose. 角度传感器的一个实例是压力传感器,例如GENovaSensorNPC-100T,其与液体/ 水管相连,所述液体/水管具有给定长度以例如4cm。 One example of the angle sensor is a pressure sensor, e.g. GENovaSensorNPC-100T, which is connected to the liquid / water, the liquid / pipe having a given length, for example, 4cm. 根据已知的公式用压力传感器读数P确定角度传感器的垂直高度H: 阳12引P=PH 阳129]其中P是管中液体密度。 P H vertical height readings determined by a pressure sensor angle sensor according to the known formula: P = PH primer male 12 male 129] where P is the density of the liquid tube. 由此,倾斜角0可W使用下述方程式计算: 阳130] 玄致1參泌T 么阳131] 在另一个实施方案中,根据本发明,光学装置328可W包括高度传感器360,如图18所示,W确定"最高位置"(使用光学装置测定)距参考点的垂直高度。 Accordingly, the inclination angle 0 may be calculated using the following equation W: male 130] Hyun 1 induced T reference it secrete the male 131] In another embodiment, according to the present invention, the optical device 328 may include a height sensor 360 W, FIG. FIG, W from the reference point to determine the vertical height of the "highest position" (using an optical measurement device) 18. 高度传感器360 包括参考贴片358,其由适于放置在皮肤上的任何材料,例如医用橡胶制成,所述参考贴片被放置在参考点(例如胸骨角或静脉静止轴)上。 Height sensor 360 includes a reference patch 358, which, for example, made of any material suitable for placement on the skin medical rubber, the reference patch is placed at a reference point (e.g., the sternal angle or intravenous stationary axis). 参考贴片358可W手动固定在参考点上;可W通过粘合剂固定位置,其中粘合剂被施加在贴片一侧,例如适用于皮肤的粘合剂如水凝胶;或者可W通过其它方式固定位置,例如带子或魔术贴(Velcro),它们能够被系紧或通过其他方式固定。 Reference patch 358 may be manually secured W at the reference point; W may be a fixed position by an adhesive, wherein the adhesive is applied on one side of the patch, the adhesive applied to the skin, for example, such as a hydrogel; or may be by W otherwise secured position, for example straps or Velcro (a Velcro), they can be fastened or secured by other means. 参考贴片358与充满液体例如水的弹性管355的一端相连。 Reference patch 358 filled with liquid water, such as an elastic tube 355 is connected to an end. 压力传感器350与充满液体的管355的另一端相连。 The pressure sensor 350 is connected to the other end 355 of the tube filled with liquid. 来自压力传感器的压力读数被用于按上述方法(P=PH)确定压力传感器350的垂直高度,H。 Pressure readings from the pressure sensor are used as described above (P = PH) determining the vertical height of the pressure sensor 350, H. 因此,当压力传感器360被放置在光学装置328之上,并且光学装置328位于"最高位置"时,那么来自压力传感器350的压力读数可被用于确定从参考点到颈静脉上产生输出信号的最高位置的高度。 Thus, when the pressure sensor 360 is placed over the optical device 328, and the optical means 328 in the "up position", the pressure reading from the pressure sensor 350 may be used to determine the reference point from the jugular vein to produce the output signal the height of the highest position.

[0132] 中屯、静脉压力还可W通过压力检测来确定,例如如上所述地确定压力波形并确定外部施加的压力。 [0132] In Tun, W venous pressure may also be determined by detecting a pressure, for example, determined as described above, the pressure waveform and determining the externally applied pressure. 在运种情况下,如所述地得到压力波形,并通过显示单元44监控压力波形。 In the transport case, as the pressure waveform obtained, the pressure waveform monitor 44 through the display unit. 然后从皮肤表面对选定的静脉血管施加外部压力,同时监测压力波形(代表基线压力)。 And then applying external pressure to the selected vein from the skin surface, while monitoring the pressure waveform (representing the baseline pressure). 提高外部施加的压力直至通过监测显示单元确定压力波形消失。 Externally applied pressure increase until the pressure monitoring unit determines that the display by the waveform disappears. 然后按下式确定中屯、静脉压P。 Is then determined as follows in the village, venous pressure P. : 阳13引Pc=Pef-Pei : 13 male primer Pc = Pef-Pei

[0134] 其中Pw,是压力波形消失时外部施加的压力值,Pm,是压力波形开始变化(或者波形幅值开始减小)时的压力值。 [0134] wherein Pw, the pressure waveform is the pressure value applied from the outside disappears, Pm, is the pressure value of the pressure waveform starts to change (or waveform amplitude starts to decrease).

[0135]根据前述的方法,可W使用包括两个光源-探测器对,或者包括两个贴片,其中每个贴片包含一个光源-探测器对的装置。 [0135] According to the aforementioned method, it comprises two light sources using W - detector pairs, or two patches, wherein each tile comprises a light source - detector pair device. 阳136]通过根据本发明的装置还可W测量中屯、静脉血流速。 Male 136] by W may Tun measuring apparatus according to the present invention, blood flow velocity. 通过测量压力波形的起落时间(t),或起落时间的平均值,可W按下式计算中屯、静脉血流速: 阳137] v = - t By measuring the pressure rise and fall time of the waveform (T), or the average of rise and fall time, it can be calculated as W in the village, blood flow rate: male 137] v = - t

[0138] 其中d是源和光探测器之间的距离;t是压力波形的上升时间(从谷值到峰值)。 [0138] where d is the distance between the source and the light detector; t is from pressure waveform rise time (from the valley to the peak value).

[0139] 可W根据下式估计血流: [0139] W can be estimated according to the formula blood flow:

[0140] F=VXS 阳141] 其中S是血管的横截面积,可W通过超声成像获得,速度(V)如上所述被确定。 [0140] F = VXS male 141] where S is the cross sectional area of ​​the vessel, W may be obtained by ultrasound imaging, velocity (V) is determined as described above.

[0142]在本发明的进一步的实施方案中,提供了相应于图1装置的装置,其适于从屯、脏静脉远程产生输出。 [0142] In a further embodiment of the present invention, there is provided an apparatus corresponding to the apparatus of FIG. 1, which is adapted to produce an output from the village, dirty remote vein. 相应地,该装置包括:远程光源,它能传送光线至患者的所希望部位,例如患者脖子上靠近屯、脏血管的部位;和远程光探测器,例如适于接收来自光源的光的CCD 照相机,所述光在所希望的部位被患者反射。 Accordingly, the apparatus comprising: a remote source, the patient can transmit light to the desired site, for example, near the patient's neck and village, dirty parts of the vessel; and a remote light detector, for example a CCD camera adapted to receive light from a light source , the light is reflected at the desired site of the patient. 如所述的,光探测器产生输出信号(例如电流/电压),该输出信号可W由信号处理装置进行处理,W产生可视输出(例如波形),用于在显示单元上显示。 As described, the photodetector generates an output signal (e.g., current / voltage), W of the output signal can be processed by the signal processing means, generating a visual output W (e.g. waveform), for displaying on the display unit. 阳143] 参考下述具体实施例对本发明的实施方案进行描述,运些实施例不应当被理解为是限制性的。 Male 143] with reference to the following specific examples will be described the embodiments of the present invention, some embodiments of operation should not be construed as limiting.

[0144] 连施例1-患者静賺搪动的测量 [0144] Example 1- administered to patients even make static movable measuring sugar

[0145]使用如图1所示的装置获得人受试者的静脉搏动。 [0145] Using the apparatus shown in FIG 1 to obtain subject human venous pulsation. 患者W大约30度的倾斜角躺在椅子上。 Patients W tilt angle of about 30 degrees lying on the chair. 装置的传感器贴片被放置在患者脖子上颈内静脉上方的位置。 The patch sensor device is placed in position on the patient's neck above the internal jugular vein. 在受试者保持正常呼吸的同时,测量并记录静脉搏动。 While maintaining normal breathing subject, venous pulse is measured and recorded. 图12显示了所记录的波形。 Figure 12 shows the waveforms recorded. 检测到的信号的幅值由y-轴表示,X-轴代表时间。 Amplitude of the signal detected by the y- axis represents, X- axis represents time. 阳连施例2-患者中屯、静脉床的测量 Example 2- male connector Tuen patient, measuring venous bed

[0147]使用如图13所示的装置获得人受试者的中屯、静脉压。 [0147] The device shown in the human subject 13 obtained Tun, venous pressure using FIG. 装置的传感器贴片被放置在患者脖子上颈内静脉上方的位置,W使得装置的末端光源/探测器位于受试者胸骨角的位置。 The patch sensor device is placed on the patient's neck above the position of the internal jugular vein, W so that the end of the light source device / detector located at a position of the subject sternal angle. 在受试者保持正常呼吸的同时,在患者平躺(0度倾斜角,例如水平)、半抬高(相对于水平为45度倾斜角)和坐直(相对于水平为90度角)的情况下,测量并记录静脉压随身体位置的变化,如图15A所示。 Subject while maintaining normal breathing, the patient is lying down (angle of 0 degree tilt, for example, horizontal), half-elevation (with respect to the horizontal tilt angle of 45 degrees) and sit straight (90 degrees with respect to horizontal angle) case, the venous pressure was measured and recorded with changes in body position, shown in Figure 15A. 测量压力由波形表示,如图15B所示,该测量压力与预期的健康患者的中屯、静脉压一致,当身体位置由水平位置抬高时压力降低。 Measuring the pressure represented by the waveform shown, the measured pressure expected in village health of the patient, the venous pressure consistent FIG. 15B, when the body horizontal position by the raised position of the pressure reduction.

[0148] 连施例3-伸用带有床力传威器的装晉测量患者CVP [0148] Even patients with measuring means Jin Example K 3- pass filter with a stretch force bed CVP

[0149] 开发了模拟患者系统W测试高度传感器装置360,如图18所示。 [0149] patient developed a simulation test height sensor system of the W device 360, as shown in FIG. 模拟系统(如图19所示)包括代表患者脖子的圆柱形组织模型,其中代表颈静脉的管410被埋置在其中。 Simulation system (19) comprises a cylindrical tissue model representing the patient's neck, wherein the representative jugular tube 410 is embedded therein. 相应的管412,与颈静脉管410在T型接头处相接,代表CVP导管,用于显示颈静脉中液体的高度。 Corresponding tube 412, the tube 410 in contact with the jugular vein in the T-joint, representative of CVP catheters, jugular vein for displaying the height of the liquid. 该系统中使用的流体是水。 The fluid used in the system water. 一条管子从T型接头处向下延伸并与橡胶"屯、脏"连接。 A tube extending down from the T-joints and connecting with the rubber "Tun, dirty." 屯、脏与旋转累相连,旋转累准确地模拟屯、脏中的屯、跳,并通过该系统将水累出。 Tun, dirty connected with the rotary tired, tired accurately simulate rotation Tun, the dirty village, jump, and by the accumulated water out of the system.

[0150] 具有L邸和光探测器328的光传感器装置(如图13所示)被放置于组织模型(地antom)表面上模拟的"颈静脉"之上的位置。 [0150] The optical pickup device (13) and having L Di photodetector 328 is placed at a position above the tissue model (the antom) simulated on the surface of "the jugular vein." 压力传感器350被放置在光学传感器装置顶部,从压力传感器延伸出去的管355与数字标尺上的可移动条(move油lebar)相连。 The pressure sensor 350 is placed on top of the optical sensor device, a movable bar (move Lebar oil) on the tube 355 extends out from the pressure sensor is connected with a digital scale. 可移动条被放置在CVP测量的"参考点"上,例如零参考点是静脉静止轴(其靠近右屯、房的位置)。 The movable bar is placed on the CVP measurement "reference point", such as a zero reference point is a stationary shaft vein (which is near the right Tun, the location of the room). 阳151]根据图18的装置被用于非侵入性地测量模拟患者的CVP。 Male 151] CVP measurement simulation patient noninvasively The apparatus 18 is used in FIG. CVP在临床上被定义为颈静脉中流体相对于零参考点的垂直高度。 CVP is defined as the vertical height of the fluid relative to the zero reference point in the jugular vein clinically. 当光学传感器被确定是位于最高位置时(例如通过监测光学传感器的输出,如前所述),来自该位置的压力传感器的压力读数被用于确定光学传感器相对于参考点的高度(即最高位置)。 When the optical sensor is at the highest position is determined (e.g., by monitoring the output of the optical sensor, as described above), pressure readings from a pressure sensor is used to determine the position of the optical sensor with respect to the height of the reference point (i.e., the highest position ). 来自压力传感器的压力读数随后被用于根据P=PH确定压力传感器的垂直高度,H。 Pressure readings from the pressure sensor is then determined according to P = PH vertical height of the pressure sensor, H. 阳15引通过与利用数字标尺得到的实际高度值进行比较,通过光学和压力传感装置"非侵入性地"获得的高度/CVP得到验证。 15 male cited by comparing the actual height value obtained using a digital scale, the height / CVP pressure sensing devices by optical and "non-invasive" obtained verified. 数字标尺的可移动条被移动至模拟"导管"中液体的顶端。 Digital scale movable bar is moved to the tip analog "conduit" in the liquid. 用数字标尺获得的高度测量值与上述装置获得的值相当,表明光学和压力传感装置准确地测量了模拟患者的CVP。 A digital scale height measurement values ​​obtained in the above-described means for obtaining equivalent, and the pressure sensing means indicate that the optical measuring accurately simulated patient CVP. 阳巧引连施例4-静脉血氣的测量 Lian Qiao cited male blood gas measurement in Example 4-

[0154] 具有两个探测器和一个光源的探头被用于确定静脉血氧(venousblood oxygenation)。 [0154] a probe has a light source and two detectors are used to determine venous oxygen (venousblood oxygenation). 探头的探测器位置与光源相距不同的距离。 Detector position the light source at different distances from the probe. 第一探测器,Dl,与光源距离2畑1,而第二探测器,D2,与光源相距2. 5畑1,如图19所示。 A first detector, Dl, and the distance from the light source 2 Hata 1, and the second detector, D2, distance from the light source 1 2.5 Hata, as shown in FIG. 光源发射两种波长的光,660nm和880nm。 Light source emitting light of two wavelengths, 660nm and 880nm.

[0155] 探头被放置在患者脖子上靠近颈内静脉的位置,在探测器2和探测器1分别测量660皿和880皿光线的信号幅值。 [0155] probe is placed on the patient's neck and a position close to the internal jugular vein, the detector 2 and the detector 1 were measured signal amplitude 660 and the dish 880 light boat. 运些值随后被用于计算每个波长的组织衰减系数(AF): 阳156] AF_660nm=D2_660nm/Dl_660nm 阳157] AF_880nm=D2_880nm/Dl_880nm These values ​​are then used to transport calculated tissue attenuation coefficient for each wavelength (AF): male 156] AF_660nm = D2_660nm / Dl_660nm male 157] AF_880nm = D2_880nm / Dl_880nm

[0158] 然后根据660皿和880皿的AF的比值计算衰减校正系数(C),即(C=AF_660nm/ AF_880nm)〇 [0158] and then calculates the attenuation correction factor (C) according to the ratio of the AF dish 660 and dish 880, i.e., (C = AF_660nm / AF_880nm) square

[0159] 使用该探头,确定基于衰减校正系数(Sjv〇2(校正)=A+B*(C*R))校正的静脉血氧。 [0159] Using this probe, the correction coefficient is determined based on the attenuation (Sjv〇2 (correction) = A + B * (C * R)) Venous Oxygen corrected. 用于该探头的A和B常数确定为:A= 1. 11,B= -0. 27。 A and B are constant for the probe is determined as: A = 1. 11, B = -0 27..

[0160] 将校正的静脉血氧与通过侵入性方法获得的实际值进行比较,发现非常吻合,而未校正的静脉血氧值与实际值存在高达大约20%的显著差异。 [0160] The corrected venous oxygen compared to the actual values ​​obtained by the invasive method, good agreement was found, whereas the corrected actual value venous oxygen presence of up significant difference of about 20%.

[0161] 参考义献 [0161] Reference Yi Xian

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Claims (18)

1. 装置,其包括: 至少一个光源,其适于发射4〇〇nm至1000 nm波长范围内的光; 至少一个光探测器,其适于接收所述光源发射的光并将所述光转换为可记录的输出, 其中所述光由患者组织反射而来或透射穿过患者组织; 至少一个探头,其有利于光从所述光源向靠近颈静脉的患者外部组织部位的传送和所述光探测器对所述患者部位反射的光或透射穿过所述患者部位的光的接收; 安装在所述探头上的高度传感器,所述高度传感器包括压力传感器,所述压力传感器通过管与参考贴片相连,其中所述管适合于容纳液体。 1. The apparatus, which comprises: at least one light source, the light in the wavelength range of 1000 nm to 4〇〇nm adapted to emit; at least one light detector adapted to receive the source light and converts the light emitted recordable output, wherein the light reflected from or transmitted through the patient's tissue by a patient's tissue; at least one probe, which is conducive to light transmitted from the external jugular vein tissue site of a patient close to the light source and the light detector portion of the patient receiving the reflected light or transmitted light passes through the portion of the patient; height sensor mounted on the probe, the height sensor comprises a pressure sensor, said pressure sensor through a tube attached to the reference sheet connected, wherein the tube is adapted to hold a liquid.
2. 如权利要求1所定义的装置,其中所述光源和所述光探测器被埋置于所述探头中。 2. The apparatus as defined in claim 1, wherein the light source and the light detector is embedded in the probe.
3. 如权利要求1所定义的装置,包括多个光探测器。 3. The apparatus defined in claim 1, comprising a plurality of photodetectors.
4. 如权利要求3所定义的装置,包括多个光源,其中每个光源发射光,所述光被所述多个光探测器的相应光探测器接收。 4. The apparatus defined in claim 3, comprising a plurality of light sources, wherein each light source emits light, the light of the respective plurality of light detectors receiving light detector.
5. 如权利要求1所定义的装置,包括多个探头,其中每个探头包含至少一个光源和至少一个光探测器。 5. The apparatus defined in claim 1, comprising a plurality of probes, wherein each probe comprises at least one light source and at least one photodetector.
6. 如权利要求1所定义的装置,其中所述探头适合于放置在患者的皮肤上。 6. The apparatus as defined in claim, wherein said probe is adapted to be placed on the patient's skin.
7. 如权利要求1所定义的装置,其中所述可记录的输出是电流或电压。 7. The apparatus as defined in claim 1, wherein said recording current or voltage is output.
8. 包括如权利要求1所定义的装置的系统,其中所述装置与信号处理装置通讯。 8. A system comprising apparatus as defined in wherein said signal processing means and the communications apparatus as claimed in claim.
9. 装置,其包括: 一个或多个光源,以发射400nm至1000 nm波长范围内的至少两种不同波长的光,波长1和波长2 ; 一个或多个光探测器,以接收由所述一个或多个光源发射的波长1和波长2的光,并将所述光转换为可记录的输出,其中所述光由患者组织反射而来或者透射穿过患者组织,其中发射和接受波长1的光的光源和光探测器之间的距离与发射和接受波长2的光的光源和光探测器之间的距离不同;以及至少一个探头,其有利于光从所述光源向靠近颈静脉的患者外部组织部位的传送和所述光探测器对所述患者部位反射而来的光或者透射穿过所述患者部位的光的接收。 9. The apparatus, comprising: one or more light sources to emit at least light, wavelength 1 and wavelength 2 at two different wavelengths in a wavelength range of 400nm to 1000 nm; the one or more light detectors, to be received by the wavelength 1 and a wavelength of light emitted from the light source 2 or more, and the output light is converted to be recorded, wherein the light reflecting from a patient's tissue or transmitted through the patient's tissue, wherein the transmission and reception wavelengths 1 and the distance between the emission source and the light detector and the light source and the distance between the light detector receiving light of different wavelength 2; and at least one probe, which is conducive to light from the light source closer to the external jugular vein of a patient light from or transmitted light through the patient tissue site receiving and transmitting site reflecting the light detector to said part of the patient.
10. 权利要求9的装置,包括至少两个光源。 10. The apparatus as claimed in claim 9, comprising at least two light sources.
11. 权利要求9的装置,包括至少两个光探测器。 11. The apparatus as claimed in claim 9, comprising at least two light detectors.
12. 权利要求9的装置,包括两个光源和两个光探测器。 12. The apparatus as claimed in claim 9, comprising two light sources and two light detectors.
13. 如权利要求9所定义的装置,其中所述光源和所述光探测器被埋置于所述探头中。 13. The apparatus defined in claim 9, wherein the light source and the light detector is embedded in the probe.
14. 如权利要求9所定义的装置,其中所述探头适合于放置在患者的皮肤上。 14. The apparatus defined in claim 9, wherein said probe is adapted to be placed on the patient's skin.
15. 如权利要求9所定义的装置,其中发射和接受波长1的光的光源和光探测器之间的距离与发射和接受波长2的光的光源和光探测器之间的距离的差异是至少大约1mm。 15. The apparatus defined in claim 9, wherein the distance between the transmission and reception of the light source and the light detector and the light emission wavelength and receiving a difference in the distance between the wavelength of the light source and the light detector is at least about 2 1mm.
16. 如权利要求9所定义的装置,其中每个光源和每个光探测器之间的距离在大约0. 5cm至大约IOcm之间。 16. The apparatus defined in claim 9, wherein a distance between each light source and each light detector of about 0. 5cm to about IOcm between. 17•如权利要求9所定义的装置,其中波长1是660nm,波长2选自880nm、905nm和940nm〇 17 • The apparatus defined in claim 9, wherein the wavelength of 660 nm is 1, the wavelength selected from 880nm, 905nm and 940nm〇
18. 包括如权利要求9所定义的第二装置的系统,其中所述装置与信号处理装置通讯。 18. The system 9 comprises a second apparatus as defined in claim, wherein said signal processing means and communication means.
19. 确定静脉血氧的方法,包括以下步骤: 使来自一个或多个光源的具有第一和第二波长的光对准靠近颈内静脉或颈外静脉的患者外部组织部位,所述第一和第二波长不同且选自400-1000nm的波长范围; 使用一个或多个光探测器,在所述第一和第二波长检测由所述组织反射而来的或者透射穿过所述组织的光,并将检测到的光转换为所述第一和第二波长的输出电流,其中发射和接受波长1的光的光源和光探测器之间的距离与发射和接受波长2的光的光源和光探测器之间的距离不同;以及使用处理器根据每一波长的光衰减确定所述患者外部组织部位的衰减校正,并对测量得到的静脉血氧应用该衰减校正,以确定静脉血氧。 19. A method of determining venous oxygen, comprising the steps of: making light having a first wavelength and a second light from one or more tissue of the patient is aligned close to the external portion of the external jugular vein or jugular vein, the first and a second wavelength different and selected from a wavelength range of 400-1000nm; using one or more light detectors, from the detected reflected by the tissue or transmitted through the tissue in the first and second wavelengths light, and converts the detected light to said first wavelength and a second output current, and wherein transmitting and receiving the distance between the emission wavelength of the light source and the light detector receiving the light 1 and light having a wavelength of 2 light sources and light different distances between the detector; and a processor using the attenuation-corrected external tissue site of a patient is determined for each wavelength of light attenuation according venous oxygen measured and the attenuation correction applied to determine the venous oxygen.
CN201480021054.4A 2007-02-16 2014-02-13 Method and device for measuring venous blood oxygenation CN105163662A (en)

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