CN105158127B - Pharmacy fluid bed granulate diameter based on pressure difference sampling is distributed on-line measuring device - Google Patents

Pharmacy fluid bed granulate diameter based on pressure difference sampling is distributed on-line measuring device Download PDF

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CN105158127B
CN105158127B CN201510637607.5A CN201510637607A CN105158127B CN 105158127 B CN105158127 B CN 105158127B CN 201510637607 A CN201510637607 A CN 201510637607A CN 105158127 B CN105158127 B CN 105158127B
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sampling
recovery
detection
fluidized
impeller
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CN105158127A (en
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魏燕定
田埂
方升
陈立
赵洁
金立帅
储燎原
瞿海斌
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Zhejiang University ZJU
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Zhejiang University ZJU
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Abstract

Pharmacy fluid bed granulate diameter based on pressure difference sampling is distributed on-line measuring device, is installed on outside fluidized-bed reaction room;Detection means has sampling mechanism, recovering mechanism and testing agency;Sampling mechanism has sampling sleeve, sampling piston and sampling impeller;Sampling channel is offered in fluidized-bed reaction room, sampling channel connects with sampling barrel bore;Sampling piston is made up of piston rod and plug, and piston rod coordinates with sampling sleeve seal, and piston rod is connected with sampling impeller, and plug is located in fluidized-bed reaction room through sampling channel;When sampling impeller is located at the first extreme position, plug closing sampling channel;When sampling impeller is located at the second extreme position, plug opens sampling channel;Sample is inputted testing agency by sampling mechanism by decelerating duct.The present invention, which has, by the real-time detection of grain diameter leads to fluidized-bed reaction outdoor, improves detection environment, the advantages of reducing detection speed and the extra cleaning attachment requirement to detection device.

Description

Pharmacy fluid bed granulate diameter based on pressure difference sampling is distributed on-line measuring device
Technical field
The present invention relates to it is a kind of can on-line checking granulation fluid bed in particle diameter distribution detection means.
Technical background
Fluid bed of pelletizing completes the granulation in pharmacy procedure, coating and a dry step, is widely used in pharmaceutical manufacturing link In.
Particle diameter range made from fluid bed not only under the influence of a step process flow, also contribute to final medicine matter Amount.Existing granulation fluidized bed process parameter is fixed in production, and the batch of raw material and environment can become over time Change, operating parameter can not change with these changes, and this will cause the drug quality uniformity of gained poor, or even not conform to Lattice.Real-time online detection is carried out to particle diameter, operating parameter can be changed according to these changes so that particle diameter distribution exists In desired scope, the process of granulation can be not only monitored, and the quality of medicine can also be controlled, so to fluid bed system The on-line checking of the diameter of particle is extremely necessary during grain.
Existing particle device detection device be divided into it is offline and online two kinds, offline inspection need the sample of collection is given To laboratory, detection has hysteresis quality, is unsatisfactory for actual requirement;And online it is divided into optic probe, capacitance probe, pressure measxurement With acoustic method etc., these detection device costs are high, and are the indirect estimation based on model, certain model error be present.And And all there is defect for above method.For example, blocking due to solid particle, easily causes the pollution of probe and detection window, The measurement of concentrated phase area is directly difficult to using image method.In addition, in fluid mapper process, particle velocity is higher, for equipment Detection speed require it is higher, add the cost of equipment.Optic probe and capacitance probe are a measuring methods, are hardly resulted in complete Office's measurement result.Acoustic measurements are easily influenceed etc. by ambient noise.Therefore, it is necessary to which new measuring method solves gas The measurement problem of solid fluid bed middle Solids Particle Diameter distribution.
The content of the invention
In order to solve how to be asked using the diameter distribution of solid particle in the accurate on-line checking fluid bed of low-cost equipment Topic, the invention provides one kind granulation fluid bed granulate diameter distribution on-line measuring device.
Pharmacy fluid bed granulate diameter based on pressure difference sampling is distributed on-line measuring device, it is characterised in that:Detection means It is installed on outside fluidized-bed reaction room;
Detection means has sampling mechanism, recovering mechanism and testing agency;
Sampling mechanism has sampling sleeve, sampling piston and sampling impeller;It is logical that sampling is offered in fluidized-bed reaction room Road, sampling channel connect with sampling barrel bore;Sampling piston is made up of piston rod and plug, piston rod and sampling sleeve seal Coordinate, piston rod is connected with sampling impeller, and plug is located in fluidized-bed reaction room through sampling channel;Sampling impeller is located at During the first extreme position, plug closing sampling channel;When sampling impeller is located at the second extreme position, it is logical that plug opens sampling Road;Sample is inputted testing agency by sampling mechanism by decelerating duct;
Testing agency has detection case and visual detection unit, the interior cavity for sealing of detection case, the outlet of decelerating duct At the top of detection case;Vision-based detection mechanism includes light source and camera, the path of the shooting area covering samples fall down of camera;
Sample is output to recovering mechanism by testing agency by reclaiming conduit.
When the plug of sampling mechanism opens sampling channel, it is allowed to which sample enters sampling sleeve from fluidized-bed reaction room;Sampling It is mutually isolated between fluidized-bed reaction room and sampling sleeve during the plug closing sampling channel of mechanism.
The local sample in fluidized-bed reaction room is taken out using sampling mechanism, the particle of fluid bed internal motion is drawn To fluidized-bed reaction outdoor, samples fall down is made in the shell of detection means, then by vision detection system to whereabouts Grain carries out the detection of particle diameter distribution.The speed of particles fall is less than the speed in fluidized-bed reaction room in detection means, avoids Particle contamination camera lens, camera can photograph clearly particles fall image, so as to accurately detect the diameter of particle Distribution situation.The real-time detection of grain diameter is led into fluidized-bed reaction outdoor, improves detection environment, is reduced to inspection The requirement of the detection speed of measurement equipment and extra cleaning attachment, whole detection device can be transformed on existing equipment, whole Individual detection means sealing, outside contamination will not be introduced to detection sample, meet GMP production standards.
Impeller can be cylinder, and the first extreme position and the second limit position are used as using the start of a run of cylinder and terminal Put.Impeller can also be motor and screw mechanism, and the first extreme position and the second pole are determined by the setting of travel switch Extreme position.
The original state of detection means is:Sampling impeller is located at the first extreme position, its plug closing sampling channel.
When sampling starts, sampling impeller moves to the second extreme position, and piston rod is to close to fluidized-bed reactor direction Motion, plug open sampling channel, connect, fluidize with sampling sleeve, decelerating duct and detection case inside fluidized-bed reactor The sample particle that bed inside reactor is in fluidized state enters collection sleeve, and sample enters detection along decelerating duct Case, the stage are the sample phase of sample particle.
Sample enters detection case from decelerating duct and falls on detection lower box part from detection upper box part, and sample is in detection case Complete to disperse by gravity, the stage is scatter stage.
Further, decelerating duct is bend pipe, entrance connection sampling sleeve, the outlet connecting detection case of decelerating duct, is slowed down The entrance of conduit is higher than outlet.Reclinate decelerating duct can slow down the movement velocity of particle, be easy to vision system to catch Particle image, carry out the distribution detection of sample particle diameter.
The particle fallen into from decelerating duct in detection case, into cameras line, camera shooting particle photo, camera obtains The image input vision processing system taken, vision processing system carry out denoising, gray processing and binaryzation to photo and pre-processed, according to The elemental area in each particle image region, completes the calculating to particle diameter, obtains particle diameter granule number in picture in its entirety Purpose is distributed, and result is preserved.After the detection time for reaching setting, camera stops collection image, and the stage is the inspection of sample The survey stage.Stop collection image using camera to complete as detection-phase.Opened by the plug of sampling mechanism in terms of sampling channel starts When, after reaching default detection time, camera stops collection image.
Further, recovering mechanism has recovery sleeve, recovery piston and recovery impeller;Offered in fluidized-bed reaction room Recovery approach, recovery approach connect with recovery barrel bore;Recovery piston is made up of piston rod and plug, piston rod and recovery set Cylinder sealing coordinates, and piston rod is connected with recovery impeller, and plug is located in fluidized-bed reaction room through recovery approach;Recovery promotes When part is located at the first extreme position, plug closing recovery approach;When recovery impeller is located at the second extreme position, plug is opened back Receive passage;When the plug of sampling mechanism opens sampling channel, the plug closing recovery approach of recovering mechanism;The plug of recovering mechanism When opening recovery approach, the plug closing sampling channel of sampling mechanism.
When the plug of recovering mechanism opens sampling channel, it is allowed to which sample enters fluidized-bed reaction room from recovery sleeve;Recovery It is mutually isolated between fluidized-bed reaction room and recovery sleeve during the plug closing recovery approach of mechanism.
After the completion of detection-phase, the plug closing sampling channel of sampling mechanism, fluidized-bed reactor inner sample particle stops Only enter sampling sleeve.Now, into sample recovery stage, the plug of recovering mechanism opens recovery approach, then to detection Case air inlet is passed through compressed gas, is in negative pressure inside fluidized-bed reactor, detection case air pressure inside is higher than fluidized-bed reactor Internal pressure, sample particle reclaims conduit because pressure differential enters from detection case bottom, returned to inside fluidized-bed reactor, complete Into the recovery of sample particle.
Further, sample sleeve and recovery sleeve is connected by respective flange portion with fluidized-bed reaction room respectively, flange Seal washer is set between portion and fluidized-bed reaction room.
Further, the light source of visual detection unit is area source, and camera lens are telecentric lens, camera, telecentric lens and Area source central coaxial line is installed.Area source sends directional light, and collimated light beam is through the particle to fall, and then light beam is by telecentric mirror Head is converged to camera imaging, is in order that the imaging size for obtaining particle will not be because of particle and camera distance using telecentric lens Change and change.
Further, light source and camera are installed on outside detection case, and relative two side plate of detection case is glass plate, face light Source is fixed on the first side plate, and camera is fixed on outside the second side plate.Camera, which is fixed on outside detection case, can avoid camera lens Polluted by sample.
Further, the air inlet that respective logical clean compressed gas is set respectively on sleeve, detection case and recovery sleeve is sampled Mouthful, air intake valve is set on air inlet.
In order that must reclaim more thoroughly, at the end of the sample stage, it is blown into short-term to the air inlet of sampling sleeve Between clean compressed gas, the sample remained in sampling mechanism and decelerating duct is purged, residual sample is dropped Into detection case.At the end of the sample dispersion stage, the clean compressed gas of short time is blown into the air inlet of detection case, it is right The sample for remaining in detection case and reclaiming in conduit is purged, and these samples drop in sleeve is reclaimed.Inside detection means Completely cut off with fluidized-bed reaction room, be passed through compressed gas and cause pressure rise in device, beneficial to recovery stage sample particle below Recovery.During recovery stage, compressed gas is passed through in recover sleeve air inlet, purges the sample remained in recover sleeve Grain, utilizes pressure differential so that sample particle is fully sucked back to fluidized-bed reactor.
After the completion of the recovery stage of sample, device reseting stage is subsequently entered.Each air intake valve is closed successively, recovering mechanism Plug closing recovery approach, inside fluidized-bed reactor and detection case isolation, the sample particle inside detection case stops entering To inside fluidized-bed reactor.The reset of finishing device, wait and sample, detect next time.
The beneficial effects of the invention are as follows:
1st, the particle inside fluid bed is led to outside fluid bed by sample mechanism, carries out deceleration processing, so Carry out the detection of particle diameter distribution to the sample particle of whereabouts by visual detection unit afterwards, improve detection environment, reduce to inspection The requirement of the detection speed of measurement equipment and extra cleaning attachment, whole detection device can be transformed on existing equipment, and And detection device seals, outside contamination is not introduced to detection sample.
2nd, by setting recovering mechanism, after the completion of sample particle diameter distribution detection, sample is sent back into stream by recovering mechanism Inside change bed reative cell, automation is all realized in collection, detection and the recovery of whole sample, reduces manual operation error and pollution Introduce, add the monitoring capability to pharmacy procedure.
3rd, camera and light source are arranged on outside detection case, sample disperses in detection case, avoids sample from polluting camera lens, obtains The image clearly taken.
4th, by setting the air inlet of compressed gas on sampling mechanism, detection case and recovering mechanism, compressed air is utilized Purging, can by sampling mechanism take out sample thoroughly reclaim, send fluidized-bed reaction chamber interior back to, avoid to sampling next time Droplet measurement impact, the accuracy of droplet measurement is high.
Brief description of the drawings
Fig. 1 is the schematic appearance when present invention is arranged on fluidized-bed reaction room.
Fig. 2 is present apparatus general structure schematic diagram.
Fig. 3 partial structural diagrams.
Fig. 4 samples tube-in-tube structure figure.
Fig. 5 samples the piston rod construction figure of piston.
Fig. 6 recover tube-in-tube structure figures.
Fig. 7 detection principle diagrams.
Fig. 8 device original state figures.
Fig. 9 sample collections, dispersity figure.
Figure 10 samples reclaim state diagram.
In figure:
Detection means A, sampling mechanism I, recovering mechanism II, testing agency III, 1, fluidized-bed reaction room, 2, sampling sleeve, 3rd, the piston of collecting mechanism, 4, sampling impeller, 5, camera, 6, telecentric lens, 7, detection case, the 8, first side plate, 9, detection case Air inlet pipe, 10, the air intake valve of detection case, 11, recovery impeller, 12, recovery piston, 13, recovery sleeve, 14, recovery set The flange portion of cylinder, 15, recovery conduit, 16, area source, 17, decelerating duct, 21, sample the feeding end of sleeve, 22, sampling sleeve Air inlet, 23, sample the end of sleeve, 31, sample the piston rod of piston, 32, the plug of sampling mechanism,
131st, reclaim sleeve feed back end, 132, reclaim sleeve air inlet, 133, reclaim sleeve end.
Embodiment
As shown in figure 1, the pharmacy fluid bed granulate diameter based on pressure difference sampling is distributed on-line measuring device, detection means peace Outside loaded on fluidized-bed reaction room.
As shown in Figures 2 and 3, detection means has sampling mechanism I, recovering mechanism II and testing agency III;Sampling mechanism I, recovering mechanism II and testing agency III inner chamber are interconnected, form the sealing space being isolated from the outside;Sampling mechanism I has There are sampling sleeve 2, sampling piston 3 and sampling impeller 4;Sampling channel is offered in fluidized-bed reaction room, sampling channel is with adopting The inner chamber of sample sleeve 2 connects;Sampling piston 3 is made up of piston rod 31 and plug 32(As shown in Figure 5), piston rod 31 is with sampling sleeve 2 sealings coordinate, and piston rod 31 is connected with sampling impeller, and plug 32 is located in fluidized-bed reaction room through sampling channel;Sampling When impeller 4 is located at the first extreme position, plug 32 closes sampling channel;When sampling impeller 4 is located at the second extreme position, block up First 32 open sampling channel;Sample is inputted testing agency III by sampling mechanism I by decelerating duct 17;Testing agency III has Detection case 7 and visual detection unit, the interior cavity for sealing of detection case 7, the outlet of decelerating duct 17 are located at the top of detection case 7; Vision-based detection mechanism III includes light source 16 and camera 5, the path of the shooting area covering samples fall down of camera 5;Testing agency Sample is output to recovering mechanism II by III by reclaiming conduit 15.
Sampling sleeve 2 is connected with fluidized-bed reactor outer wall by flange portion, and the piston rod 31 of sampling piston 3 passes through sampling The end of sleeve 2.The feeding end of plug 32 and sampling sleeve 2 coordinates.
As shown in figure 4, sampling sleeve 2 divides for both ends:Feeding end 21 and the remote fluid bed for inserting fluidized-bed reaction room are anti- Answer the end 23 of room.The feeding end 21 of sampling sleeve 2 is used as sampling channel, and sampling channel contacts with sampling mechanism I plug 32 And separation so that completely cut off and communicate with external environment inside fluidized-bed reactor.Feeding end 21 has to be entered for what compressed air entered Gas port 22, the sample particle of sampling sleeve 2 and decelerating duct 17 is remained in for purging.End is connected with decelerating duct 17, from The sample particle that fluidized-bed reactor comes out enters detection case 7 by decelerating duct 17.
The external diameter for sampling the plug 32 of piston is more than the internal diameter of the sampling entrance of sleeve 2.The piston rod 31 of piston 3 is sampled with adopting The push rod of sample impeller 4 is fixed together.
Sampling mechanism I plug 32 with sample sleeve 2 feeding end be in contact when, i.e. plug 32 closing sampling channel When, it will can be opened inside fluidized-bed reactor with the isolation of the environment of detection case 7;Sampling mechanism I plug 32 and the sampling pan feeding of sleeve 2 When end is when be not in contact with, i.e. plug 32 opens sampling channel, fluidized-bed reactor inside is connected with the environment of detection case 7.
As shown in figure 4, decelerating duct 17 is bend pipe, the entrance connection sampling sleeve 2 of decelerating duct 17, outlet connecting detection Case 7, the entrance of decelerating duct 17 is higher than outlet.Reclinate decelerating duct 17 can slow down the movement velocity of particle, be easy to Vision system catches particle image, carries out the distribution detection of sample particle diameter.
Recovering mechanism II has recovery sleeve 13, recovery piston 12 and recovery impeller 11;Opened up in fluidized-bed reaction room There is recovery approach, recovery approach connects with recovery sleeve 13 inner chamber;Recovery piston 12 be made up of piston rod and plug, piston rod with Reclaim the sealing of sleeve 13 to coordinate, piston rod is connected with recovery impeller 11, and plug is located at fluidized-bed reaction room through recovery approach It is interior;When recovery impeller 11 is located at the first extreme position, plug closing recovery approach;Recovery impeller 11 is located at the second limit position When putting, plug opens recovery approach;When sampling mechanism I plug opens sampling channel, recovering mechanism II plug closing recovery Passage;When recovering mechanism II plug opens recovery approach, sampling mechanism I plug closing sampling channel.
As shown in fig. 6, recover sleeve is divided into both ends:Feed back end 131 and end 133.Open one end is feed back end 131, the feed back end 131 and recovering mechanism II plug are contacting and separating so that inside fluidized-bed reactor and external environment every Absolutely and communicate.There is the air inlet 132 of the recovery sleeve 13 entered for compressed air end 133, and recovery set is remained in for purging The sample particle of cylinder 13 and recovery conduit 15, so that sample recovery is abundant.End 133 is connected with recovery conduit 15, from detection case 7 Sample particle out is entered inside fluidized-bed reactor by reclaiming conduit 15 from detection case 7.
Recovery conduit 15 is bend pipe, reclaims entrance connecting detection case 7, the outlet connection recovery sleeve 13 of conduit 15, recovery The entrance of conduit 15 is higher than outlet.Reclinate recovery conduit 15 can make particle fall under gravity into recovery set Cylinder.
As shown in fig. 7, vision-based detection mechanism III includes light source 16 and camera 5, the shooting area of camera 5 is covered under sample The path fallen;Light source 16 is area source 16, and the camera lens of camera 5 is telecentric lens, and camera 5, telecentric lens and the center of area source 16 are same Axis is installed.Area source 16 sends directional light, and collimated light beam is converged to phase through the particle to fall, then light beam by telecentric lens Machine 5 is imaged, be using telecentric lens in order that the imaging size of particle will not become because of the change of particle and the distance of camera 5 Change.
Light source and camera 5 are installed on outside detection case 7, and relative two side plate of detection case 7 is glass plate, area source 16 It is fixed on the first side plate 8, camera 5 is fixed on outside the second side plate.Camera 5, which is fixed on outside detection case 7, can avoid camera mirror Head is polluted by sample.
The operating procedure of the present invention is as follows:
1), preparation, carry out fluid bed preparation, including add bottom powder, connection and sets fluidisation at liquid-jet device Bed operating parameter, run fluid bed.Reset and check droplet measurement device so that droplet measurement device is in original state, opens Open detection means.
2nd, with scattered, sampling impeller 4 moves sample collection from the first extreme position to the second extreme position, promotes sampling The piston rod of piston 3 moves to close to fluidized-bed reactor direction, and sampling mechanism I plug separates with sampling channel, fluid bed Inside reactor and detection case 7 communicate, and the sample particle in fluidized state enters sampling set inside fluidized-bed reactor Cylinder 2, enters detection case 7 along decelerating duct 17, completes the collection of sample particle.Fallen on from the top of detection case 7 under detection case 7 Portion, complete to disperse by gravity in detection case 7, as shown in Figure 9.
3rd, vision-based detection, the particle fallen into from decelerating duct 17 in detection case 7, into vision-based detection scope, vision system Particle photo is shot, vision system carries out denoising, gray processing and binaryzation to photo and pre-processed, according to each particle image region Elemental area, complete the calculating to particle diameter, obtain the distribution of particle diameter numbers of particles in picture in its entirety, and by result Preserve.After the detection time for reaching setting, vision system stops collection image.
4th, sample reclaims, and sampling impeller 4 moves from the second extreme position to the first extreme position, samples the work of piston 3 Stopper rod is moved to away from fluidized-bed reactor direction, and the piston rod butt end of sampling piston 3 contacts with sampling channel, and plug closing is adopted Sample passage, fluidized-bed reactor inside and detection case 7 completely cut off, and fluidized-bed reactor inner sample particle stops entering sampling set Cylinder 2.The sampling air inlet of sleeve 2 is passed through compressed air, and the sample particle remained in sampling sleeve 2 and decelerating duct 17 is purged To detection case 7.Recovery impeller 11 moves from the first extreme position to the second extreme position, promotes recovering mechanism II piston Bar moves to close to fluidized-bed reactor direction, and recovering mechanism II plug separates with reclaiming the feed back end 131 of sleeve 13, fluidizes Bed inside reactor and detection case 7 communicate.Detection case 7 purges air inlet valve and opened, and compressed air is passed through, by the bottom of detection case 7 The sample particle in portion is dispersed in whole detection case 7, and hyperbar is in detection case 7, negative pressure, sample are in inside fluidized-bed reactor Product particle reclaims conduit 15 because pressure differential enters from the bottom of detection case 7, returns to inside fluidized-bed reactor, completes sample The recovery of grain.In order that sample recovery is more abundant, compressed gas is passed through in the recovery air inlet of sleeve 13, recovery set will be remained in Sample particle in cylinder 13 is purged to fluidized-bed reactor, as shown in Figure 10.
5th, device resets, and detection case 7 purges air inlet valve and closed.Recover electric expansion device is to after-contraction, recycling machine Structure II piston rod moves to away from fluidized-bed reactor direction, the feed back end of recovering mechanism II plug and recovery sleeve 13 131 contacts, plug closing recovery approach, fluidized-bed reactor inside and detection case 7 completely cut off, the sample particle inside detection case 7 Stopping is entered inside fluidized-bed reactor.The reset of finishing device, prepare to sample next time, detect, as shown in Figure 8.
Content described in this specification embodiment is only enumerating to the way of realization of inventive concept, protection of the invention Scope is not construed as being only limitted to the concrete form that embodiment is stated, protection scope of the present invention is also and in art technology Personnel according to present inventive concept it is conceivable that equivalent technologies mean.

Claims (6)

1. the pharmacy fluid bed granulate diameter based on pressure difference sampling is distributed on-line measuring device, it is characterised in that:Detection means is pacified Outside loaded on fluidized-bed reaction room:Detection means has sampling mechanism, recovering mechanism and testing agency:There is sampling mechanism sampling to cover Cylinder, sampling piston and sampling impeller:Sampling channel is offered in fluidized-bed reaction room, sampling channel connects with sampling barrel bore It is logical:Sampling piston is made up of piston rod and the top of a wall, and piston rod coordinates with sampling sleeve seal, and piston rod connects with sampling impeller Connect, the top of a wall is located in fluidized-bed reaction room through sampling channel:When sampling impeller is located at extreme position, the top of a wall closing is adopted Sample passage:When sampling impeller is located at the second extreme position, the top of a wall opens sampling channel:Sampling mechanism is by decelerating duct by sample Product input testing agency:Testing agency has detection case and visual detection unit, the interior cavity for sealing of detection case, decelerating duct Outlet be located at the top of detection case:Vision-based detection mechanism includes light source and camera, the shooting area covering samples fall down of camera Path:Sample is output to recovering mechanism by testing agency by reclaiming conduit;
Recovering mechanism has recovery sleeve, recovery piston and recovery impeller:Recovery approach is offered in fluidized-bed reaction room, is returned Passage is received to connect with recovery barrel bore:Recovery piston is made up of piston rod and the top of a wall, and piston rod coordinates with recovery sleeve seal, Piston rod is connected with recovery impeller, and the top of a wall is located in fluidized-bed reaction room through recovery approach:Recovery impeller is located at pole During extreme position, the top of a wall closing recovery approach:When recovery impeller is located at the second extreme position, the top of a wall opens recovery approach:Sampling When the top of a wall of mechanism opens sampling channel, the top of a wall closing recovery approach of recovering mechanism:It is logical that the top of a wall of recovering mechanism opens recovery During road, the top of a wall closing sampling channel of sampling mechanism.
2. the pharmacy fluid bed granulate diameter as claimed in claim 1 based on pressure difference sampling is distributed on-line measuring device, it is special Sign is:Decelerating duct is bend pipe, the entrance connection sampling sleeve of decelerating duct, exports connecting detection case, decelerating duct enters Mouth is higher than outlet.
3. the pharmacy fluid bed granulate diameter as claimed in claim 2 based on pressure difference sampling is distributed on-line measuring device, it is special Sign is:Sampling sleeve and recovery sleeve are connected by respective flange portion with fluidized-bed reaction room respectively, flange portion and fluidisation Seal washer is set between bed reative cell.
4. the pharmacy fluid bed granulate diameter as claimed in claim 3 based on pressure difference sampling is distributed on-line measuring device, it is special Sign is:The light source of visual detection unit is area source, and camera lens are telecentric lens, in camera, telecentric lens and area source Heart coaxial line is installed.
5. the pharmacy fluid bed granulate diameter as claimed in claim 4 based on pressure difference sampling is distributed on-line measuring device, it is special Sign is:Light source and camera are installed on outside detection case, and relative two side plate of detection case is glass plate, and area source is fixed on On first side plate, camera is fixed on the second side plate.
6. the pharmacy fluid bed granulate diameter as claimed in claim 5 based on pressure difference sampling is distributed on-line measuring device, it is special Sign is:The air inlet of respective logical clean compressed gas, air inlet are set respectively on sampling sleeve, detection case and recovery sleeve Upper setting air intake valve.
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