CN105147250B - A portable optical coherence tomograph - Google Patents

A portable optical coherence tomograph Download PDF

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CN105147250B
CN105147250B CN201510509005.1A CN201510509005A CN105147250B CN 105147250 B CN105147250 B CN 105147250B CN 201510509005 A CN201510509005 A CN 201510509005A CN 105147250 B CN105147250 B CN 105147250B
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beam
light
grating
camera
portable
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CN105147250A (en
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刘海军
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苏州塞罗尔医学影像科技有限公司
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Abstract

本发明公开种便携式光学相干层析成像仪,包括可发出具有不同波长的单束光的宽带光源、使单束光通过后形成线性光束的狭缝、将该线性光束分离成参考光束与测量光束的分束镜,参考光束与测量光束分别经参考反射镜、物镜反射或散射后在分束镜上形成干涉光束,该干涉光束经光栅后被色散形成具有不同波长的出射光,出射光经便携式或可穿戴的智能设备后即可得到待测对象的二维断层图。 Species present invention discloses a portable optical coherence tomography apparatus, comprising a broadband light source can emit a single beam of light having different wavelengths, the beam of the single slit is formed after the light passes through the linear beam, separating the linear beam into a reference beam and a measuring beam the beam splitter, the reference beam and the measurement beam respectively by the reference mirror, after the objective lens is reflected or scattered is formed on a beam splitter interference light beam, the interference light beam by the grating after the dispersion is formed the outgoing light having different wavelengths, the emitted light is portable It can be obtained after the object to be measured or smart device wearable two-dimensional tomogram. 该成像仪采用了便携式或可穿戴的智能设备代替了现有的光谱仪,其可实现随身携带、随时诊断、操作方便且及价格便宜,有利于广泛使用,且易于实现远程医疗和大数据分析。 The imager uses a portable or wearable smart devices replace the existing spectrometer, which can be realized portable, ready to diagnose, easy to operate and and the price is cheap, it is conducive to widespread use, and easy to implement telemedicine and big data analytics.

Description

一种便携式光学相干层析成像仪 A portable optical coherence tomograph

技术领域 FIELD

[0001] 本发明涉及光学成像技术领域,特别涉及一种便携式光学相干层析成像仪。 [0001] Technical Field The present invention relates to optical imaging, and particularly relates to a portable optical coherence tomograph.

背景技术 Background technique

[0002] 光学相千层析成像(0CT)是一种新兴的光学成像技术。 [0002] The optical phase tomography one thousand (0CT) is a new optical imaging technique. 它以非侵入性的方式、极高的速度形成高分辨率的生物组织剖面图。 It is a non-invasive manner, high speed formation of a high-resolution cross-sectional biological tissue. 该技术自1991年问世以来,为临床诊断及医疗研究带来了显著的影响。 The advent of technology since 1991, has brought significant impact on the clinical diagnosis and medical research. 在过去的10年中,每年都有超过2000万名患者成为0CT成像技术的受益者。 In the past 10 years, each year more than 20 million patients become beneficiaries of 0CT imaging technology. 然而现有0CT设备造价昂贵(约合60-80万人民币/台),个人无法承担设备费用,严重阻碍了这种有效诊断技术的普及;而且,现有0CT设备体积、重量较大,无法实现随身携带, 也在一定程度上影响其更为广泛的应用。 However, the existing 0CT equipment is expensive (about 60-80 ten thousand yuan / Taiwan), individuals can not afford the cost of equipment, a serious impediment to the popularity of this effective diagnostic techniques; moreover, existing 0CT equipment volume, heavy weight, can not be achieved carry, but also affect the wider range of applications to some extent.

[0003] 而目前,一个典型的SD-0CT设备,参见图1所示,包括以下组成部分:光源110;干涉仪120;参考臂130;光谱仪140;样品臂150。 [0003] At present, a typical SD-0CT device, see Figure, the part 1 comprising: a light source 110; interferometer 120; a reference arm 130; 140 spectrometer; sample arm 150. 千涉仪通常有4个接口,分别连接光源、参考臂、 光谱仪、样品臂四个部分。 Intervention instrument usually has four interfaces, are connected to four light source portion, a reference arm, a spectrometer, a sample arm. 宽带光源的输出光通过进入干涉仪后分成两个部分,一部分经干涉仪到达样品臂,另一部分到达参考臂。 Outputted by the broadband light source into the interferometer is divided into two portions, a portion of the sample reaching the interferometer arm, the other portion reaches the reference arm. 到达样品臂的光经样品散射后原路返回干涉仪;同样,到达参考臂的光经过参考反射镜反射后按原路返回干涉仪。 After the light is scattered by the sample reaches the sample arm interferometer backtrack; Similarly, after reaching the original optical path of the reference arm mirror reflected back upon reference interferometer. 回到干涉仪的两束光在干涉仪处发生干涉,部分干涉光经干涉仪到达光谱仪,光谱仪接受到干涉光后将其转换为电信号。 Back interferometer two-beam interference light generating interferometer, the interferometer portion of the interference light is reaching the spectrometer, the spectrometer receives interference light after converting it into an electric signal. 计算机从光谱仪读取包含光谱干涉信号的光谱仪输出数据,通过光谱域线性校正和反傅立叶变化后得到样品的断面图像。 The computer reads from the spectrometer comprising a spectrometer interferometer spectrum data signal output by the spectral domain to obtain cross-sectional image of the sample after the linearity correction and inverse Fourier transform. 在所有组件当中,光谱仪和计算机最为复杂、昂贵。 Among all components, a spectrometer and a computer the most complex and expensive.

发明内容 SUMMARY

[0004] 本发明的目的是提供一种价格便宜、携带方便、可随时诊断的便携式光学相干层析成像仪。 [0004] The object of the present invention is to provide an inexpensive, easy to carry, at any time of the portable diagnostic optical coherence tomograph.

[0005] 为达到上述目的,本发明采用的技术方案是:一种便携式光学相干层析成像仪,包括: [0005] To achieve the above object, the technical solution of the present invention is that: a portable optical coherence tomography apparatus, comprising:

[0006] 宽带光源,可发出具有不同波长的单束光;该宽带光源能发出波长为11、12、……、 In的单束光; [0006] The broadband light source can emit a single beam having different wavelengths; the broadband light source emits a wavelength of 11,12, ......, In a single beam;

[0007] 狭缝,位于所述宽带光源出光路径上,所述单束光经所述狭缝后形成线性光束; [0007] slit in said light path a broadband light source, said single light beam to form a linear light beam through said slot;

[0008] 分束镜,位于所述线性光束出光路径上,将所述线性光束分离成被导向参考反射镜的参考光束、被导向待测对象的测量光束; [0008] The beam splitter is positioned on the linear path of the light beam, the linear beam is directed into a separate reference mirror of the reference beam, the measuring beam is guided to the object to be measured;

[0009] 准直透镜,位于所述狭缝与所述分束镜间,使经所述狭缝后形成的所述线性光束准直; [0009] The collimator lens positioned in the slit of the linear beam between the beam splitter points, so the slit is formed by the collimated;

[0010] 物镜,位于所述分束镜与所述待测对象间,使所述测量光束准直地集中在所述待测对象上; [0010] the objective lens, the beam splitter positioned to the object to be measured between, the collimated measuring beam focused on the object to be measured;

[0011] 光栅,所述参考光束、所述测量光束分别经所述参考反射镜、所述物镜反射或散射后在所述分束镜中合光形成干涉光束,所述光栅位于所述千涉光束的出光路径上,所述干涉光束经所述光栅后发生色散,形成具有不同波长的出射光; [0011] grating, the reference beam, the measuring beam through the reference mirror, respectively, the reflected or scattered by the object lens in the optical beam splitter are combined to form an interference light beam, said grating located intervention the light path of the light beam, the light beam after the interference grating disperses, forming the outgoing light having different wavelengths;

[0012] 便携式或可穿戴的智能设备,所述智能设备包括相机透镜、相机、摄像头,所述出射光入射通过所述相机透镜聚焦后分别到达所述相机的光敏面上形成不同的线焦点,所述摄像头探测到所述相机输出的不同像素信号后经傅里叶变换得到所述待测对象的二维断层图。 [0012] The portable or wearable smart device, said smart device includes a camera lens, a camera, a camera, respectively, after reaching the exit light incident on the focusing lens formed by the different camera focal line of the photosensitive surface of the camera, obtained after the object to be measured to detect the different camera pixel signal outputted from said camera Fourier transformed two-dimensional tomogram.

[0013] 优选地,所述光源为LH)宽带光源。 [0013] Preferably, the light source is LH) broadband source.

[0014] 优选地,所述的智能设备为手机或平板电脑。 [0014] Preferably, the device is a smart phone or tablet.

[0015] 进一步优选地,所述出射光中具有与所述宽带光源波长相同的中心波长光束,所述相机透镜、所述相机的中心点均位于所述出射光的出光路径上,通过计算所述光栅出射光的出射角来调整所述相机、所述相机透镜与所述光栅间的位置,所述光栅出射光的出射角满足: [0015] Further preferably, the outgoing light having the central wavelength of the broadband light source same wavelength beam, the camera lens, the center point of the camera are located on the light path of the outgoing light by calculating said grating light emitted to adjust the angle of the camera, the camera position between the lens and the grating, the grating output angle of the emitted light satisfies:

[0016]关系式:nA=d(sin9+sin0'); [0016] relationship: nA = d (sin9 + sin0 ');

[0017] 其中A是所述中心波长光束的波长,即为所述宽带光源的中心波长;n是光栅衍射级;d是光栅常数;e是光栅入射角,即为所述干涉光束与所述光栅法线间的夹角;0'是光栅出射角,即为所述出射光与所述光栅法线间的夹角。 [0017] wherein A is the wavelength of the center wavelength of the beam, i.e. the center wavelength of the broadband light source; n is the grating diffraction order; D is the grating constant; E is the incident angle of the grating, i.e. the interference with the light beam the angle between the normal of the grating; 0 'is a grating angle, i.e. the angle between the emitted light and the grating normal.

[0018]由于上述技术方案的运用,本发明与现有技术相比具有下列优点:本发明的便携式光学相干层析成像仪,通过在干涉光束的出光路径上设置光栅及便携式智能设备,其携带方便,可随时进行诊断,且其与现有的光谱仪相比,价格更低,且易于实现远程医疗和大数据分析。 [0018] As the use of the above technical solution, the present invention has the following advantages over the prior art: a portable optical coherence tomography device according to the present invention, by providing the grating and a portable intelligent device on the light path of the interference light beam, which carries convenient, can be diagnosed at any time, and its comparison with the conventional spectrometer, lower prices, and easy to implement telemedicine and big data analytics.

附图说明 BRIEF DESCRIPTION

[0019]附图1为现有技术中的SD-0CT设备的结构示意图; [0019] Figure 1 is a schematic view of a prior art SD-0CT device;

[0020]附图2为本发明所述的一种便携式光学相千层析成像仪的结构示意图; Phase one thousand schematic structure of a portable tomography apparatus according to the optical [0020] Figure 2 of the present invention;

[0021] 其中:110、光源;120、干涉仪;130参考臂;140、光谱仪;150、样品臂; [0021] wherein: 110, a light source; 120, interferometer; reference arm 130; 140 spectrometer; 150, sample arm;

[0022] 1、宽带光源(LED宽带光源);2、狭缝;3、准直透镜;4、分束镜;5、参考反射镜;6、物镜;7、待测对象;8、光栅;9、智能设备;91、相机透镜;92、相机。 [0022] 1, a broadband light source (LED broadband light source); 2, a slit; 3, a collimator lens; 4, beam splitter; 5, reference mirror; 6, an objective lens; 7, object to be measured; 8, a raster; 9, intelligent devices; 91, a camera lens; 92, a camera.

具体实施方式 Detailed ways

[0023]下面结合附图及具体实施例来对本发明的技术方案作进一步的阐述。 [0023] Specific examples of the further aspect of the present invention is described below in conjunction with the accompanying drawings and.

[0024]参见图2所示,一种便携式光学相干层析成像仪,包括宽带光源1,该宽带光源丄可发出具有不同波长的单束光;狭缝2,位于宽带光源1的出光路径上,该单束光经过该狭缝2 后形成线性光束;分束镜4,位于线性光束的出光路径上,将该线性光束分离成被导向参考反射镜5的参考光束、被导向待测对象7的测量光束;准直透镜3,位于狭缝2与分束镜4间,使经狭缝2后形成的线性光束准直;物镜6,位于分束镜4与待测对象7间,使测量光束准直地集中在待测对象7上;光栅8,该参考光束、测量光束分别经参考反射镜5、物镜6发射或散射后在分束镜4中合光形成干涉光束,该光栅8位于干涉光束的出光路径上,该干涉光束经该光栅8后发生色散,形成具有不同波长出射光,而后通过便携式或可穿戴的智能设备9进行检测。 [0024] Referring to Figure, a portable optical coherence tomography device 2, comprises a broadband light source 1, the broadband light source can emit a single beam Shang having different wavelengths; slit 2, it is located on the optical path of the broadband light source 1 the single beam through the slit to form a linear light beam 2; a beam splitter 4, is located on the optical path of the linear beam, separating the linear beam into a reference beam is guided to a reference mirror 5, the object to be measured is guided 7 the measuring beam; a collimator lens 3, the linear light beam is located a slit beam splitter 2 and 4, so that the slit formed by the collimator 2; objective lens 6, beam splitter 4 and located object to be measured 7, the measurement collimated light beam focused on the object to be measured 7; grating 8, the reference beam, the measuring beam through the reference mirror 5, respectively, after the objective lens 6 to form an interference light beam emitted or scattered by the light combined in the beam splitter 4, the grating 8 located on the optical path of the interference light, it disperses the interference light beam by the grating 8 after forming the outgoing light having different wavelengths, and then detected by the intelligent portable or wearable device 9. 在这里,该宽带光源1为LED宽带光源1,使用LED宽带光源1与点光源相比具有造价低、体积小、功耗低的优点,LED宽带光源1本身所发出的光束较为发散,经狭缝2后形成线性光束, 需通过增加准直透镜3才能变成一条方向性很强的近似准直光束。 Here, the broadband light source is a broadband source 1 is an LED 1, LED using a broadband light source 1 and a point light source as compared with low cost, small size, low power consumption advantages, the light beam itself emitted from the broadband light source LED 1 is more divergent, the narrow after formation of the linear slit beam 2, by increasing the required collimator lens 3 in order to become a strong directional approximately collimated light beam.

[0025]在这里,该成像仪的检测机构为便携式或可穿戴的智能设备9,在本实施例中,该智能设备9为手机,也可以是平板电脑。 [0025] Here, the imager detection means is a portable or wearable smart device 9, in the present embodiment, the smart phone device 9 may be a tablet. 该智能设备9包括相机透镜91、相机92、摄像头,出射光入射通过该相机透镜91聚焦后分别到达该相机92的光敏面上形成不同的线焦点,摄像头探测到该相机92输出的不同的像素信号后经傅里叶变换得到待测对象7的二维断层图。 The intelligent device 9 includes a camera lens 91, the camera 92, the camera, the outgoing light enters to form different line focus of the photosensitive surface 92 by the camera lens are reaching the camera after 91 focus, the camera detects different pixels 92 output from the camera after the object to be measured to obtain two-dimensional tomographic signal of FIG. 7 via the Fourier transform. 而如果是采用了手机作为智能设备9,则通过手机应用显示到手机屏幕上。 And if it is using the phone as an intelligent device 9, through mobile applications displayed on the phone screen. 在这里,通过该智能设备9替代了现有技术中的光谱仪,其价格便宜、结构简单、便于携带、操作方便,易于实现远程医疗和大数据分析。 Here, the smart device 9 by replacing the prior art spectrometer which is inexpensive, simple in structure, easy to carry, easy to operate, easy to implement large data analysis and telemedicine.

[0026] 在这里,该干涉光束经过光栅8色散后形成的具有不同波长的出射光中该出射光中具有与宽带光源1的中心波长相同的中心波长光束,该相机透镜91、相机92的中心均位于该出射光的出光路径上,通过计算光栅出射光的出射角来调整相机92、相机透镜91与光栅8 间的位置,该光栅出射光的出射角满足: [0026] Here, the interference output light having different wavelengths of light through the grating 8 dispersion formed the outgoing light having a center wavelength of the broadband source 1 is the same as the center wavelength of beam 91, the center of the camera lens camera 92 are located on the light path of the emitted light, the camera 92 is adjusted by calculating the grating angle of the emitted light 91 to the position 8 of a camera lens grating, which the light exit angle satisfies:

[0027] 关系式:nA=d (sin9+sin9'); [0027] relationship: nA = d (sin9 + sin9 ');

[0028] 其中X是中心波长光束的波长,即为宽带光源1的中心波长;n是光栅衍射级;d是光栅常数;9是光栅入射角,即为干涉光束与光栅法线间的夹角;e'是光栅出射角,即为出射光与光栅法线间的夹角。 [0028] where X is the wavelength of the center wavelength of the beam, i.e. the center wavelength of the broadband light source 1; n is the grating diffraction order; D is the grating constant; grating 9 is the angle of incidence, i.e. the angle between the interfering beams normal to the grating ; e 'is the grating output angle, i.e. the angle between the outgoing light and the normal to the grating.

[0029] 上述实施例只为说明本发明的技术构思及特点,其目的在于让熟悉此项技术的人士能够了解本发明的内容并据以实施,并不能以此限制本发明的保护范围。 [0029] The embodiment for explaining the technical concept and features of the invention, its object is to only allow those skilled in the art to understand the present invention and according to embodiments, and not limit the scope of this invention. 凡根据本发明精神实质所作的等效变化或修饰,都应涵盖在本发明的保护范围之内。 Where an equivalent changes or modifications made from the spirit of the present invention, shall fall within the scope of the present invention.

Claims (3)

1.一种便携式光学相干层析成像仪,其特征在于,包括: 宽带光源,可发出具有不同波长的单束光; 狭缝,位于所述宽带光源出光路径上,所述单束光经所述狭缝后形成线性光束; 分束镜,位于所述线性光束出光路径上,将所述线性光束分离成被导向参考反射镜的参考光束、被导向待测对象的测量光束; 准直透镜,位于所述狭缝与所述分束镜间,使经所述狭缝后形成的所述线性光束准直; 物镜,位于所述分束镜与所述待测对象间,使所述测量光束准直地集中在所述待测对象上; 光栅,所述参考光束、所述测量光束分别经所述参考反射镜、所述物镜反射或散射后在所述分束镜中合光形成干涉光束,所述光栅位于所述干涉光束的出光路径上,所述干涉光束经所述光栅后发生色散,形成具有不同波长的出射光; 便携式或可穿戴的智能设备,所述智能 A portable optical coherence tomograph, characterized by comprising: a broadband light source can emit a single beam having different wavelengths; slit, positioned on the optical path of the broadband light source, a single light by the later slit to form a linear beam; beam splitter is positioned on the linear path of the light beam, separating the linear beam is directed into a reference mirror reference beam, the measuring beam is guided to the object to be measured; collimator lens, located between the slit beam and the sub-mirror, so that through said slit after forming the linear beam collimator; an objective lens, a beam splitter located in the object to be measured between the points, the measuring beam collimated focused on the object to be measured; grating, the reference beam, the measuring light beams back through the reference mirror, the reflected or scattered by the objective lens in the optical beam splitter are combined to form an interference beam the grating is located on the optical path of the interference light beam, said interference light beam dispersion occurs after the grating forming the outgoing light having different wavelengths; intelligent portable or wearable device, the smart 备包括相机透镜、相机、摄像头,所述出射光入射通过所述相机透镜聚焦后分别到达所述相机的光敏面上形成不同的线焦点,所述摄像头探测到所述相机输出的不同像素信号后经傅里叶变换得到所述待测对象的二维断层图; 所述出射光中具有与所述宽带光源波长相同的中心波长光束,所述相机透镜、所述相机的中心点均位于所述出射光的出光路径上,通过计算所述光栅出射光的出射角来调整所述相机、所述相机透镜与所述光栅间的位置,所述光栅出射光的出射角满足: 关系式:nA=d (sin0+sinQ'); 其中A是所述中心波长光束的波长,B卩为所述宽带光源的中心波长;n是光栅衍射级;d 是光栅常数;9是光栅入射角,即为所述干涉光束与所述光栅法线间的夹角;0'是光栅出射角,即为所述出射光与所述光栅法线间的夹角。 Apparatus includes a camera lens, a camera, camera, respectively, after the arrival of the emitted light is incident through the focusing lens of the camera to form different focal line of the photosensitive surface of the camera, said camera to detect said different pixel signals output from the camera the object to be measured is obtained by Fourier transform of the two-dimensional tomographic; center point of the exit light from the broadband light source having a center wavelength beam of the same wavelength, the camera lens, the camera are located in the the light path of the emitted light is adjusted by calculating the angle of said grating light exiting the camera, the camera position between the lens and the grating, the grating output angle of the emitted light satisfies: relationship: nA = d (sin0 + sinQ '); wherein a is the center wavelength of the light beam, B Jie as the center wavelength of the broadband light source; n is the grating diffraction order; D is the grating constant; grating 9 is the angle of incidence, is the desired said interference light beam and the angle between the normal of said grating; 0 'is a grating angle, i.e. the angle between the emitted light and the grating normal. _ 、 _,
2. 根据权利要求1所述的便携式光学相千层析成像仪,其特征在于:所述光源为LED宽带光源〇 The phase of the portable optical tomograph as claimed in one thousand claims, characterized in that: the LED light source is a broadband source billion
3. 根据权利要求1所述的便携式光学相干层析成像仪,其特征在于:所述的智能设备为手机或平板电脑。 Claim 3. The portable optical coherence tomography instrument of claim 1, wherein: said device is a smart phone or tablet.
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