CN105121447A - 长春碱类衍生物及其制备方法和应用 - Google Patents

长春碱类衍生物及其制备方法和应用 Download PDF

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Publication number
CN105121447A
CN105121447A CN201480022198.1A CN201480022198A CN105121447A CN 105121447 A CN105121447 A CN 105121447A CN 201480022198 A CN201480022198 A CN 201480022198A CN 105121447 A CN105121447 A CN 105121447A
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vinca
compound
hydrazinolysis
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CN105121447B (zh
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叶文才
陈河如
张冬梅
陈敏峰
许男徽
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Jinan University
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Jinan University
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Priority claimed from CN201310138241.8A external-priority patent/CN103275106B/zh
Priority claimed from CN201310738860.0A external-priority patent/CN104740602B/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

本发明提供一类新的长春碱类衍生物及其新应用和制备方法。所述长春碱类衍生物包括肼解长春碱类化合物和长春碱类二肽衍生物。所述的肼解长春碱类化合物为长春碱类化合物或其盐与水合肼反应所得到的化合物；所述的长春碱类二肽衍生物为肼解长春碱类化合物与N-苄氧羰基甘氨酰脯氨酸缩合所得的化合物。本发明提供了所述长春碱类衍生物或其药物组合在抗肿瘤、预防或治疗糖尿病性视网膜病变、类风湿关节炎以及作为血管生成抑制剂或者血管阻断剂中的用途。

Description

PCT国内申请，说明书已公开。

Claims (1)

  1. PCT国内申请，权利要求书已公开。
CN201480022198.1A 2013-04-19 2014-03-03 长春碱类衍生物及其制备方法和应用 Active CN105121447B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201480022198.1A CN105121447B (zh) 2013-04-19 2014-03-03 长春碱类衍生物及其制备方法和应用

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
CN201310138241.8A CN103275106B (zh) 2013-04-19 2013-04-19 一种吲哚生物碱加合物及其制备方法和在制备抗肿瘤药物中的应用
CN2013101382418 2013-04-19
CN2013107388600 2013-12-30
CN201310738860.0A CN104740602B (zh) 2013-12-30 2013-12-30 长春碱及其类似物的应用
PCT/CN2014/000192 WO2014169697A1 (zh) 2013-04-19 2014-03-03 长春碱类衍生物及其制备方法和应用
CN201480022198.1A CN105121447B (zh) 2013-04-19 2014-03-03 长春碱类衍生物及其制备方法和应用

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CN105121447A true CN105121447A (zh) 2015-12-02
CN105121447B CN105121447B (zh) 2018-02-02

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US (1) US10377774B2 (zh)
EP (1) EP2987794B1 (zh)
JP (1) JP6250710B2 (zh)
CN (1) CN105121447B (zh)
AU (1) AU2014253584B2 (zh)
WO (1) WO2014169697A1 (zh)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112603989A (zh) * 2017-07-18 2021-04-06 暨南大学 长春碱类衍生物在制备抑制肿瘤转移药物中的应用
CN113456797A (zh) * 2021-06-18 2021-10-01 暨南大学 长春碱类衍生物在制备治疗骨肉瘤和/或软组织肉瘤药物中的应用

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114894927B (zh) * 2022-04-28 2023-11-21 广西壮族自治区食品药品检验所 瑶药白背三七中吡咯里西啶生物碱的含量测定方法

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112603989A (zh) * 2017-07-18 2021-04-06 暨南大学 长春碱类衍生物在制备抑制肿瘤转移药物中的应用
CN113456797A (zh) * 2021-06-18 2021-10-01 暨南大学 长春碱类衍生物在制备治疗骨肉瘤和/或软组织肉瘤药物中的应用
CN113456797B (zh) * 2021-06-18 2024-03-08 暨南大学 长春碱类衍生物在制备治疗骨肉瘤和/或软组织肉瘤药物中的应用

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AU2014253584B2 (en) 2017-02-02
CN105121447B (zh) 2018-02-02
WO2014169697A1 (zh) 2014-10-23
US10377774B2 (en) 2019-08-13
US20160068552A1 (en) 2016-03-10
JP6250710B2 (ja) 2017-12-20
EP2987794B1 (en) 2018-05-30
EP2987794A1 (en) 2016-02-24
EP2987794A4 (en) 2016-11-30
JP2016511251A (ja) 2016-04-14
AU2014253584A1 (en) 2015-10-08

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