New! View global litigation for patent families

CN105092680A - Cassette device used for capillary electrophoresis apparatus - Google Patents

Cassette device used for capillary electrophoresis apparatus Download PDF

Info

Publication number
CN105092680A
CN105092680A CN 201510506948 CN201510506948A CN105092680A CN 105092680 A CN105092680 A CN 105092680A CN 201510506948 CN201510506948 CN 201510506948 CN 201510506948 A CN201510506948 A CN 201510506948A CN 105092680 A CN105092680 A CN 105092680A
Authority
CN
Grant status
Application
Patent type
Prior art keywords
capillary
cassette
needle
mounting
body
Prior art date
Application number
CN 201510506948
Other languages
Chinese (zh)
Other versions
CN105092680B (en )
Inventor
余丁
鲍志伟
徐礼友
颜进
吴勇
Original Assignee
宁波海尔施基因科技有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Abstract

The invention discloses a cassette device used for a capillary electrophoresis apparatus. The device comprises a cassette body and a gel storage pipe arranged on the cassette body; the cassette body is provided with a capillary mounting hole and a capillary chamber communicated with the capillary mounting hole, a needle mounting part is arranged on the cassette body, a sampling needle is arranged in the needle mounting part, the sampling needle extends out of the cassette body, the capillary is mounted in the capillary mounting hole, one end of the capillary extends into the sampling needle, the other end of the capillary extends into the gel storage pipe, and the middle of the capillary is wound in the capillary chamber. According to the invention, due to the arrangement of the capillary chamber, the capillary is wound in the capillary chamber, so that capillaries with different lengths can be mounted on the cassette device to adapt to the analysis and detection of different samples.

Description

应用于毛细管电泳仪的卡匣装置 Capillary electrophoresis apparatus is applied to the cassette

技术领域 FIELD

[0001] 本发明涉及毛细管电泳仪领域,具体涉及一种应用于毛细管电泳仪的卡匣装置。 [0001] The present invention relates to capillary electrophoresis, and in particular relates to a device applied to the cassette capillary electrophoresis instrument.

背景技术 Background technique

[0002] 生物分析,例如DNA分析,正在进行从追求精确的纯粹科学探索到具有更大的及已证实的可靠性的常规程序的快速转变。 [0002] biological analysis, such as DNA analysis, ongoing exploration from the pursuit of purely scientific precision to quickly change the reliability of conventional programs with greater and proven. 毛细管电泳(capillary electrophoresis,CE)是一类以毛细管为分离通道、以高压直流电场为驱动力的新型液相分离技术,通常采用毛细管电泳仪进行DNA检测分析和蛋白质分离分析。 Capillary electrophoresis (capillary electrophoresis, CE) is a new type of liquid phase separation techniques to capillary as separation channel, to the field of high voltage direct current driving force, usually separated by capillary electrophoresis analysis apparatus for DNA analysis and protein detection. 但现有的毛细管电泳仪的卡匣装置包括匣体,该匣体上开设有安装毛细管的毛细管安装孔,该毛细管的长度取决于匣体的长度,因此需要更换检测样品时,可能需要移动至另一毛细管电泳仪进行检测,这就造成了工作效率低下,需要投入多台毛细管电泳仪,造成投入成本提高。 However, when the conventional cassette apparatus comprising a capillary electrophoresis device of the cartridge, the capillary tube defines a capillary mounted on the cassette body mounting holes, the length of the capillary tube depend on the length of the cartridge, it is necessary to replace the test sample, it may be required to move another capillary electrophoresis to detect, which resulted in inefficiency, requires a multiple capillary electrophoresis instrument, resulting in higher input costs. 而且现有的毛细管电泳仪的分离通道,检测窗口,电极和凝胶存储罐装均是相互独立的部分,造成仪器结构复杂,制造成本高,不利于日常的维护,也使得更换毛细管及凝胶的操作人员需要有较高的技术能力。 And the existing separation channel capillary electrophoresis apparatus, the detection window, the electrodes and the gel storage cans are independent parts, resulting in complicated apparatus structure, high manufacturing costs, is not conducive to routine maintenance, and also makes replacement of the capillary gel operators need to have high technical ability.

发明内容 SUMMARY

[0003]( 一)要解决的技术问题 [0003] (a) To solve technical problems

[0004] 本发明要解决的技术问题是提供一种结构简单,可配置不同长度毛细管,适用于不同毛细管电泳的卡匣装置。 [0004] The present invention is to solve the technical problem to provide a simple structure, it can be configured with different length of the capillary for capillary electrophoresis cassettes of different means.

[0005] ( 二)技术方案 [0005] (ii) Technical Solution

[0006] 为解决上述技术问题,本发明提供一种应用于毛细管电泳仪的卡匣装置,其包括匣体,以及安装在匣体上的凝胶储存管;匣体上设置有毛细管安装孔以及与毛细管安装孔相连通的毛细管腔,匣体上设置有针头安装部,针头安装部内安装有抽样针头,该抽样针头伸出匣体外,毛细管安装于毛细管安装孔内,毛细管的一端伸入抽样针头内,另一端伸入凝胶储存管内,毛细管的中部缠绕于毛细管腔内。 [0006] To solve the above problems, the present invention provides an apparatus applied to the cassette capillary electrophoresis device comprising the cartridge, and the gel storage tube is mounted on the cartridge; a capillary tube is provided on the cartridge mounting holes and capillary mounting hole communicating the capillary cavity, the cartridge is provided on the mounting portion with a needle, the needle mounting portion of a needle attached to the sample, the sampling needle extending cartridge body, the capillary is attached to the mounting hole of the capillary, the end of the capillary extends into the sample needle the other end extending into the reservoir within the gel tube, the capillary tube is wound around the middle of the capillary cavity.

[0007] 其中,匣体上位于毛细管安装孔处开设有检测窗口。 [0007] wherein the mounting hole on the cartridge defines a capillary with a detection window.

[0008] 其中,匣体内位于检测窗口的两端分别设置有遮光套,毛细管依次穿过遮光套。 [0008] wherein the detection window is located at both ends of the body are provided with a light-shielding cartridge sleeve, capillary tube passes through the light shielding sleeve.

[0009] 其中,凝胶储存管上开设有环形槽,凝胶储存管通过环形槽卡扣在匣体上。 [0009] wherein the gel storage tube defines an annular groove, the annular groove by gel storage tube snap on the cartridge.

[0010] 其中,匣体由上、下两个半匣体对合后连接而成。 [0010] wherein the cartridge by the upper and lower half of the box rear are linked together.

[0011] 其中,至少一个半匣体的边缘开设有开口。 [0011] wherein the at least one edge of the cassette half body defines an opening.

[0012] 其中,每个半匣体内都均匀设置有多个加强筋。 [0012] wherein, each cartridge body half provided with a plurality of uniformly bead.

[0013] 其中,加强筋上开设有开槽。 [0013] wherein the reinforcing defines a slot on the tendons.

[0014] 其中,卡匣装置还包括金属电极P (即正极,P为英文positive的简称)和金属电极N(即负极,P为英文negative的简称),金属电极P安装于凝胶储存管的第一安装孔内,金属电极N套装于针头安装部的第二安装孔内。 [0014] wherein the apparatus further comprises a metal electrode cassette P (i.e., positive electrode, positive for the English abbreviation P) and a metal electrode N (i.e., a negative electrode, the negative English abbreviation P), P is mounted on the metal electrode gel containing tube a first mounting hole, a second set of metal electrodes N mounting hole in the needle mounting portion.

[0015] 其中,第一安装孔与凝胶储存管上存储凝胶的空腔相连通。 [0015] wherein the first mounting hole and the gel reservoir tube storage cavity communicating gel.

[0016](三)有益效果 [0016] (c) beneficial effect

[0017] 与现有技术相比,本发明具有如下特点: [0017] Compared with the prior art, the present invention has the following characteristics:

[0018] (I)通过设置毛细管腔,毛细管缠绕于毛细管腔内,使卡匣装置能安装不同长度的毛细管,以适应不同样品的分析检测; [0018] (I) provided by the capillary cavity, the capillary tube is wound in a capillary cavity, and the device can be installed the capillary cassette of different lengths to accommodate different samples of analytical testing;

[0019] (2)将毛细管电泳装置中的毛细管、检测窗口、电极和凝胶存储四个关键部分整合为一个整体,简化了仪器结构,减少了故障率,便于日常的维护,便于操作人员的操作; [0019] (2) the capillary capillary electrophoresis apparatus, the detection window, and a gel electrode key store four partial integration as a whole, simplifying the structure of equipment, reducing the failure rate, easy routine maintenance, easy for the operator to operating;

[0020] (3)本发明独立于仪器主机部分,成为一种专用耗材,可根据不同的应用目的,配备不同配方的凝胶或特定规格的毛细管(例如毛细管的口径,长度,涂层等),而且更换方便; [0020] (3) The present invention is independent of the main part of the instrument become a special supplies, according to different application purposes, gel or capillary with different formulations of a particular size (e.g., capillary caliber, length, coating, etc.) and easy to replace;

[0021] (4)本发明内不含有光学装置,其分离通道无需与侦测区域进行光学精对准。 [0021] (4) does not contain optical device of the present invention within which the separation channel without fine alignment with the optical detection area.

附图说明 BRIEF DESCRIPTION

[0022] 图1是本发明应用于毛细管电泳仪的卡匣装置的立体结构示意图。 [0022] FIG. 1 is a perspective schematic structural view of a cassette device of the present invention is applied to a capillary electrophoresis device.

[0023] 图2是本发明应用于毛细管电泳仪的卡匣装置去掉半匣体后的立体结构示意图。 [0023] FIG. 2 is a perspective schematic structural diagram of the present invention is applied after half the cartridge capillary electrophoresis apparatus to remove the cassette.

[0024] 图3是本发明应用于毛细管电泳仪的卡匣装置的半匣体的立体结构示意图。 [0024] FIG. 3 is a perspective schematic view of a cassette device of the present invention is applied to a semi-capillary electrophoresis device of the cartridge.

[0025] 图中,1-匣体;2_凝胶储存管;3_抽样针头;4_毛细管;5_遮光套;11_毛细管安装孔;12-毛细管腔;13-检测窗口; 14-开槽;15-开口; 16-加强筋;17-安装槽;18-针头安装部;19_第二安装孔;21_环形槽;22_管盖;23_管体;24_第一安装孔;51_台阶。 [0025] FIG, 1 the cartridge; 2_ gel reservoir tube; 3_ sampling needle; 4_ capillary; 5_ shielding cover; 11_ capillary attachment hole; 12- capillary cavity; 13- detection window; 14- slot; opening 15; 16- rib; 17- mounting groove; 18 needle mounting portion; 19_ second mounting hole; 21_ annular groove; a 22-tube cap; 23_ tubular body; a first mounting 24_ aperture; 51_ step.

具体实施方式 detailed description

[0026] 下面结合附图和实施例,对本发明的具体实施方式作进一步详细描述。 [0026] The following embodiments and the accompanying drawings, specific embodiments of the present invention will be further described in detail. 以下实施例用于说明本发明,但不能用来限制本发明的范围。 The following examples serve to illustrate embodiments of the present invention, but not to limit the scope of the present invention.

[0027] 本发明应用于毛细管电泳仪的卡匣装置的立体结构如图1和图2所示,该卡匣装置包括匣体1,安装在匣体I的凝胶储存管2,匣体I上设置有毛细管安装孔11以及毛细管安装孔11相连通的毛细管腔12,匣体I上设置有安装抽样针头3的针头安装部18,该抽样针头3伸出上述匣体I外,毛细管4安装于上述毛细管安装孔11内,该毛细管4的一端伸入上述抽样针头3内,另一端伸入上述凝胶储存管2内,该毛细管4的中部缠绕于毛细管腔12内。 [0027] The present invention is applied to three-dimensional structure of the capillary electrophoresis instrument cassette apparatus shown in FIGS. 1 and 2, the cassette means comprises a cassette body 1, 2 is mounted in the cartridge, the cartridge storage pipe I I gels the mounting hole 11 is provided with a capillary tube and the capillary attachment hole 11 communicating the capillary cavity 12, is provided on the cartridge mounting sampling needle I of the needle mounting portion 183 of the sampling needle above the cartridge 3 protrudes outside I, the capillary tube 4 is mounted mounting hole in the capillary tube 11, one end of the capillary tube 4 extending into said sampling needle 3, and the other end extending into the reservoir 2 above the gel tube, the capillary tube is wound around the central chamber 124 of the capillary.

[0028] 上述匣体I上开设有检测窗口13,该检测窗口13正对于毛细管安装孔11,使毛细管外露,检测窗口13外安装有激光激发装置和光信号接收装置,该激光激发装置发出的光纤方向与毛细管的流向呈45°,光信号接收装置方向与与毛细管的流向也呈45°,可避免光纤直接射入光信号接收装置上,避免过强光的影响。 [0028] defines the I above the cartridge has a detection window 13, the detection window 13 n For capillary attachment hole 11, the capillary exposed, the detection window 13 outer mounting laser excitation means and the optical signal receiving apparatus, a fiber optic device emits the laser excitation capillary flow direction was 45 °, light receiving means and the capillary flow direction signal and also was 45 °, the optical fiber can be avoided directly incident on the light signal receiving means, avoiding excessive influence of light.

[0029] 匣体I内位于检测窗口13的两端分别设置有遮光套5,毛细管4依次穿过遮光套5,可调整检测窗口的大小。 [0029] I within the cartridge detection window 13 located at both ends are provided with a shielding sleeve 5, the capillary tube 4 passes through the light-shielding cover 5, the detection window is resizable.

[0030] 上述匣体I内开设有安装槽17,上述遮光套5的台阶51卡扣在安装槽17内,保证遮光套固定安装在匣体内。 [0030] I within the mounting groove 17 is defined above the cartridge, the light-shielding stepped sleeve 51 is mounted within the buckle 5 of the groove 17, to ensure the light shielding sleeve fixedly mounted cartridge body.

[0031] 凝胶储存管2上开设有环形槽21,凝胶储存管2通过环形槽21卡扣在匣体I上,简化了凝胶储存管与匣体的连接方式,而且结构简单、安装方便。 [0031] The gel reservoir tube 2 defines an annular groove 21, the gel reservoir pipe 2 through the annular groove 21 on snap the cartridge I, simplifies the connection with the cartridge gel reservoir tube, and the structure is simple, the installation Convenience.

[0032] 上述凝胶储存管2包括管体23和安装在管体23上的管盖22,管体23上开设有安装凝胶的空腔,上述环形槽开设在管体23上,便于凝胶储存管的安装,可拆卸式管盖的设置便于凝胶装入空腔内或者更换空腔内的凝胶。 [0032] The gel tube 2 comprises a storage tube 23 and the tubular body 23 is mounted on the pipe cover 22, defines a cavity 23 mounted on a tubular body of a gel, said annular groove opened in the tubular body 23, to facilitate condensate installation plastic storage tubes, removable tube cap is provided to facilitate the replacement of gel loading cavity or cavities of the gel.

[0033] 上述毛细管通过固定件(图中未示出)固定安装在凝胶储存管内,并浸没在凝胶之中,而且毛细管与固定件之间设置有密封件,避免凝胶泄漏。 [0033] The gel capillary leak by a fixing member (not shown) fixedly mounted within the gel reservoir tube, and immersed in the gel, and a seal member disposed between the capillary tube and fixed, to avoid.

[0034] 匣体I由上、下两个半匣体对合后连接而成,半匣体的结构如图3所示,这样可以便于凝胶储存管和毛细管的安装。 [0034] I the cartridge by the upper and lower half of the box rear are linked together, the structure of the cartridge half 3, which can facilitate to store the gel and capillary tube mounting.

[0035] 至少一个半匣体的边缘开设有开口15,开口可以开设在一个半匣体上,也可以在两个半匣体上都开设开口,拆卸时,便于手或其他物体伸入而跷开上下半匣体,便于毛细管的更换。 [0035] The edge of at least a half of the box 15 defines an opening, the opening can be opened in a cassette half body, may be on the cartridge are two half defines the opening, disassembly, easy hand or other object projects into the Rocker upper and lower halves open the cartridge for easy replacement of the capillary.

[0036] 每个半匣体内都均匀设置有多个加强筋16,提高匣体的结构强度;该加强筋16上开设有开槽14,用于定位毛细管。 [0036] Each cartridge body half provided with a plurality of uniformly rib 16, to improve the structural strength of the box; the reinforcement 14 defines a slotted rib 16 for positioning the capillary.

[0037] 上述卡匣装置还包括金属电极P和金属电极N,金属电极P安装于凝胶储存管2的第一安装孔24内,第一安装孔24与凝胶储存管2上存储凝胶的空腔相连通,该金属电极P的一端暴露在外,另一端与空腔内的凝胶直接接触;金属电极N套装于针头安装部18的第二安装孔19内,金属电极N形如一根钢针,套在第二安装孔内,既可以保护毛细管又可以实现电极的作用。 [0037] The cassette means further include a metal electrode and a metal electrode P N, P metal electrode 2 is mounted in the first mounting hole gel reservoir tube 24, a first mounting hole 24 on the second storage reservoir with the gel tube gel a cavity communicating, at one end of the metal electrode P is exposed, in direct contact with the other end of the cavity gel; N set of metal electrodes in the second mounting hole 18 of the needle mounting portion 19, shaped like a metal electrode N needle, set in a second mounting hole, both to protect the capillary and the working electrode can be achieved.

[0038] 工作时,先在凝胶储存管内施加一定压力,使凝胶流入毛细管内,再将抽样针头放置于样品内,再放置于缓冲液中,并在两端施加电压,此时样品在毛细管内电泳,在凝胶的作用下,样本分子产生分离,样本分子在激光的激发下发生荧光反应,并由接收装置采集并对其进行分析。 [0038] In operation, to exert a certain pressure storage pipe in the gel, the gel flows into the capillary, the sample needle is then placed in the sample buffer then be enclosed, and a voltage is applied across the sample at this point in capillary electrophoresis, under the action of the gel, the sample molecules separated, fluorescent molecules in the reaction sample excitation laser light, by the receiving apparatus can be collected and analyzed. 本发明通过设置毛细管腔,毛细管缠绕于毛细管腔内,使同一中卡匣装置能安装多种不同长度的毛细管,以适应不同样品的检测,检测不同样品时只需更换不同毛细管长度的卡匣装置即可;而且将毛细管电泳装置中的毛细管、检测窗口、电极和凝胶存储四个关键部分整合为一个整体,简化了仪器结构,减少了故障率,并使之独立于仪器主机部分,成为一种专用耗材,便于日常的维护,便于操作人员的操作。 Simply replacing cassettes of different means by setting the length of the capillary when the capillary cavity of the present invention, the capillary tube is wound in a capillary cavity, and the same apparatus can be installed in the cassette plurality of capillaries of different lengths, to accommodate the detection of different samples, different samples detected can; and the capillary capillary electrophoresis apparatus, the detection window, and a gel electrode key store four partial integration as a whole, simplifying the structure of equipment, reducing the failure rate, and the instrument independent host part, into a special kinds of supplies, to facilitate routine maintenance, easy to operate operator.

[0039] 以上仅为本发明的优选实施方式,应当指出,对于本技术领域的普通技术人员来说,在不脱离本发明技术原理的前提下,还可以做出若干改进和润饰,这些改进和润饰也应视为本发明的保护范围。 [0039] The above description is only preferred embodiments of the present invention, it should be noted that those of ordinary skill in the art, in the art without departing from the principles of the present invention, can make various improvements and modifications, such modifications and modifications should be the scope of the present invention.

Claims (10)

  1. 1.一种应用于毛细管电泳仪的卡匣装置,其特征在于:所述卡匣装置包括匣体(I),以及安装在所述匣体⑴上的凝胶储存管⑵;所述匣体⑴上设置有毛细管安装孔(11)以及与所述毛细管安装孔(11)相连通的毛细管腔(12),所述匣体(I)上设置有针头安装部(18),所述针头安装部(18)内安装有抽样针头(3),该抽样针头(3)伸出所述匣体(I)夕卜,毛细管(4)安装于所述毛细管安装孔(11)内,所述毛细管(4)的一端伸入所述抽样针头(3)内,另一端伸入所述凝胶储存管(2)内,所述毛细管(4)的中部缠绕于所述毛细管腔(12)内。 A cassette apparatus is applied to a capillary electrophoresis device, characterized in that: said cassette means comprises a cassette body (the I), and gel ⑵ storage tube mounted on said cassette body ⑴; said cartridge body a capillary tube is provided ⑴ mounting hole (11) and a mounting hole of the capillary (11) is connected through a capillary chamber (12), said cassette body (I) is provided with a needle mounting portion (18) on said needle mounting the inner portion (18) is attached to the sampling needle (3), the sampling needle (3) extending out of said cassette body (I) Bu Xi, the capillary tube (4) mounted in said capillary attachment hole (11), said capillary (4) into said one end of the sampling needle (3), and the other end extending into said reservoir gel tube (2), the middle of the capillary tube (4) is wound around said capillary chamber (12).
  2. 2.根据权利要求1所述的应用于毛细管电泳仪的卡匣装置,其特征在于:所述匣体(I)上位于所述毛细管安装孔(11)处开设有检测窗口(13)。 2. The apparatus of claim 1 applied to the cassette capillary electrophoresis device according to claim, wherein: said cartridge body positioned in the mounting hole capillary (11) (I), the detection window is opened (13).
  3. 3.根据权利要求2所述的应用于毛细管电泳仪的卡匣装置,其特征在于:所述匣体(I)内位于所述检测窗口(13)的两端分别设置有遮光套(5),所述毛细管(4)依次穿过所述遮光套(5)。 3. The apparatus of claim 2 is applied to the cassette capillary electrophoresis device according to claim, wherein: said inner box (I) is located at both ends of the detection window (13) are provided with a shielding sleeve (5) the capillary tube (4) passes through the shielding sleeve (5).
  4. 4.根据权利要求1所述的应用于毛细管电泳仪的卡匣装置,其特征在于:所述凝胶储存管(2)上开设有环形槽(21),所述凝胶储存管(2)通过所述环形槽(21)卡扣在所述匣体(I)上。 The cassette device according to claim 1, applied to capillary electrophoresis device claims, characterized in that: defines an annular groove (21) on the gel reservoir pipe (2), the gel reservoir tube (2) (21) snap onto the cassette body (I) by the annular groove.
  5. 5.根据权利要求1至4任一项所述的应用于毛细管电泳仪的卡匣装置,其特征在于:所述匣体(I)由上、下两个半匣体对合后连接而成。 The apparatus 1 is applied to cassette according to any one of claims 4 to capillary electrophoresis device, as claimed in claim wherein: said cassette body (I) by the upper and lower half of the cartridge are linked together after .
  6. 6.根据权利要求5所述的应用于毛细管电泳仪的卡匣装置,其特征在于:至少一个所述半匣体的边缘开设有开口(15)。 6. The cassette 5 is applied to the capillary electrophoresis device according to claim, wherein: said at least one edge of the cassette half body defines an opening (15).
  7. 7.根据权利要求5所述的应用于毛细管电泳仪的卡匣装置,其特征在于:每个所述半匣体内都均匀设置有多个加强筋(16)。 7. The cassette 5 is applied to the capillary electrophoresis device as claimed in claim wherein: each said cartridge body half provided with a plurality of uniformly rib (16).
  8. 8.根据权利要求7所述的应用于毛细管电泳仪的卡匣装置,其特征在于:所述加强筋(16)上开设有开槽(14)。 8. The apparatus of claim 7 is applied to the cassette capillary electrophoresis device according to claim, wherein: said reinforcing defines a slot (14) on the rib (16).
  9. 9.根据权利要求1所述的应用于毛细管电泳仪的卡匣装置,其特征在于:所述卡匣装置还包括金属电极P和金属电极N,所述金属电极P安装于所述凝胶储存管(2)的第一安装孔(24)内,所述金属电极N套装于所述针头安装部(18)的第二安装孔(19)内。 9. The apparatus of claim 1 applied to the cassette capillary electrophoresis device according to claim, wherein: said cassette means further comprises a metal electrode and a metal electrode P N, P of the metal electrode is attached to the gel reservoir the inner tube (2) of the first mounting hole (24), the metal electrode of the N set (19) in the second mounting hole of the needle mounting portion (18).
  10. 10.根据权利要求9所述的应用于毛细管电泳仪的卡匣装置,其特征在于:所述第一安装孔(24)与所述凝胶储存管(2)上存储凝胶的空腔相连通。 10. The apparatus of claim 9 applied to the cassette capillary electrophoresis device according to claim, wherein: the storage chamber is connected to a gel on the first mounting hole (24) and the gel reservoir tube (2) through.
CN 201510506948 2015-08-18 2015-08-18 Capillary electrophoresis apparatus is applied to the cassette CN105092680B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN 201510506948 CN105092680B (en) 2015-08-18 2015-08-18 Capillary electrophoresis apparatus is applied to the cassette

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN 201510506948 CN105092680B (en) 2015-08-18 2015-08-18 Capillary electrophoresis apparatus is applied to the cassette

Publications (2)

Publication Number Publication Date
CN105092680A true true CN105092680A (en) 2015-11-25
CN105092680B CN105092680B (en) 2018-03-27

Family

ID=54573588

Family Applications (1)

Application Number Title Priority Date Filing Date
CN 201510506948 CN105092680B (en) 2015-08-18 2015-08-18 Capillary electrophoresis apparatus is applied to the cassette

Country Status (1)

Country Link
CN (1) CN105092680B (en)

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4911807A (en) * 1989-09-05 1990-03-27 Bio-Rad Laboratories, Inc. Fractionation and sample loading by cassette in capillary electrophoresis
DE4230355A1 (en) * 1991-09-10 1993-03-11 Hitachi Ltd DNA measuring process and appts. - using fluorescent marker at end of mol. which is straightened and passed through zone to detect interval between markers
JP2002139475A (en) * 1985-09-18 2002-05-17 Univ Leland Stanford Jr Fluorescence detection and interface electrokinetic separation method and device
CN1485614A (en) * 2002-09-24 2004-03-31 财团法人工业技术研究院 Card box for electrophoresis checking apparatus and method for manufacturing the same
CN1494654A (en) * 2001-01-26 2004-05-05 比奥卡尔技术公司 Multi-channel bio-separation cartridge
US6870165B2 (en) * 2001-10-19 2005-03-22 Biocal Technology, Inc. Multi-color multiplexed analysis in a bio-separation system
US20060113191A1 (en) * 1998-02-16 2006-06-01 The Institute Of Physical And Chemical Research Capillary cassette and method of manufacturing the same
US20060194306A1 (en) * 2003-08-25 2006-08-31 Herr Amy E System for gel electrophoretic immunoassay
CN101165472A (en) * 2006-10-20 2008-04-23 中国科学院大连化学物理研究所 Multiple-pass mode capillary tube electrophoresis device
CN103328963A (en) * 2010-08-24 2013-09-25 光鼎生物科技股份有限公司 Disposible bio-analysis cartridge and instrument for conducting bio-analysis using same
CN103868970A (en) * 2014-03-21 2014-06-18 上海通微分析技术有限公司 Full-automatic high-precision capillary electrophoresis apparatus
CN203732553U (en) * 2013-12-30 2014-07-23 深圳市理邦精密仪器股份有限公司 Medical capillary adapter, test card component and blood gas analyzer

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002139475A (en) * 1985-09-18 2002-05-17 Univ Leland Stanford Jr Fluorescence detection and interface electrokinetic separation method and device
US4911807A (en) * 1989-09-05 1990-03-27 Bio-Rad Laboratories, Inc. Fractionation and sample loading by cassette in capillary electrophoresis
DE4230355A1 (en) * 1991-09-10 1993-03-11 Hitachi Ltd DNA measuring process and appts. - using fluorescent marker at end of mol. which is straightened and passed through zone to detect interval between markers
US20060113191A1 (en) * 1998-02-16 2006-06-01 The Institute Of Physical And Chemical Research Capillary cassette and method of manufacturing the same
CN1494654A (en) * 2001-01-26 2004-05-05 比奥卡尔技术公司 Multi-channel bio-separation cartridge
US6870165B2 (en) * 2001-10-19 2005-03-22 Biocal Technology, Inc. Multi-color multiplexed analysis in a bio-separation system
CN1485614A (en) * 2002-09-24 2004-03-31 财团法人工业技术研究院 Card box for electrophoresis checking apparatus and method for manufacturing the same
US20060194306A1 (en) * 2003-08-25 2006-08-31 Herr Amy E System for gel electrophoretic immunoassay
CN101165472A (en) * 2006-10-20 2008-04-23 中国科学院大连化学物理研究所 Multiple-pass mode capillary tube electrophoresis device
CN103328963A (en) * 2010-08-24 2013-09-25 光鼎生物科技股份有限公司 Disposible bio-analysis cartridge and instrument for conducting bio-analysis using same
CN203732553U (en) * 2013-12-30 2014-07-23 深圳市理邦精密仪器股份有限公司 Medical capillary adapter, test card component and blood gas analyzer
CN103868970A (en) * 2014-03-21 2014-06-18 上海通微分析技术有限公司 Full-automatic high-precision capillary electrophoresis apparatus

Also Published As

Publication number Publication date Type
CN105092680B (en) 2018-03-27 grant

Similar Documents

Publication Publication Date Title
Renzi et al. Hand-held microanalytical instrument for chip-based electrophoretic separations of proteins
US6353475B1 (en) Light source power modulation for use with chemical and biochemical analysis
Zhang et al. Microfabricated devices for capillary electrophoresis− electrospray mass spectrometry
Pumera et al. New materials for electrochemical sensing VII. Microfluidic chip platforms
Mellors et al. Fully integrated glass microfluidic device for performing high-efficiency capillary electrophoresis and electrospray ionization mass spectrometry
Yin et al. Microfluidic chip for peptide analysis with an integrated HPLC column, sample enrichment column, and nanoelectrospray tip
US4816123A (en) Method of fabricating capillary electrophoresis separation channels
US5636017A (en) Optical detection arrangement for small volume chemical analysis of fluid samples
Deng et al. Chip-based capillary electrophoresis/mass spectrometry determination of carnitines in human urine
Mellors et al. Integrated microfluidic device for automated single cell analysis using electrophoretic separation and electrospray ionization mass spectrometry
US3049118A (en) Ion electrode assembly
Liu et al. Determination of sulpiride by capillary electrophoresis with end-column electrogenerated chemiluminescence detection
US20050148063A1 (en) Disposable reaction vessel with integrated optical elements
US5985121A (en) Fast sampling device and sampling method for capillary electrophoresis
US5110431A (en) On-capillary gap junction for fluorescence detection in capillary electrophoresis
US5571398A (en) Precise capillary electrophoretic interface for sample collection or analysis
US5770029A (en) Integrated electrophoretic microdevices
Meng et al. Interfacing a polymer-based micromachined device to a nanoelectrospray ionization Fourier transform ion cyclotron resonance mass spectrometer
Holland et al. Highlight. Capillary electrophoresis coupled to electrochemical detection: a review of recent advances
US6162341A (en) Multi-channel capillary electrophoresis device including sheath-flow cuvette and replacable capillary array
US3619068A (en) Refractometer
US20080182136A1 (en) Microscale Electrochemical Cell And Methods Incorporating The Cell
Ling et al. Simultaneous determination of glutathione and reactive oxygen species in individual cells by microchip electrophoresis
Liu et al. Capillary isoelectric focusing of proteins with liquid core waveguide laser-induced fluorescence whole column imaging detection
Fu et al. Laser-induced fluorescence detection system for microfluidic chips based on an orthogonal optical arrangement

Legal Events

Date Code Title Description
C06 Publication
C10 Entry into substantive examination