CN105055242A - Gardenoside antipruritic skin care essence and preparation method thereof - Google Patents
Gardenoside antipruritic skin care essence and preparation method thereof Download PDFInfo
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Abstract
The invention discloses gardenoside antipruritic skin care essence and a preparation method thereof. The gardenoside antipruritic skin care essence is prepared from the following raw materials in weight percentage: 0.7-1% of gardenoside, 25-30% of towel gourd stem juice, 1-3% of propylene glycol, 0.5-1% of PEG-40 hydrogenated castor oil, 1.5-2% of L-menthol, 0.3-0.5% of borneol, 0.1-0.3% of thymol, 1.0-1.5% of gardenia essence, 0.1-0.3% of sodium citrate and the balance of ethanol. According to the invention, towel gourd stem juice and gardenoside are adopted as the principal raw materials, have the skin care functions of anti-allergy and antiphlogosis, mosquito repellent and itching relief, refreshment, skin cytothesis promotion and anti-aging, and fully express the characteristics of green and natural plants, so that the gardenoside antipruritic skin care essence is safe to use and free of toxic or side effect.
Description
Technical field
The present invention relates to plant type floral water technical field, more specifically refer to that a kind of gardenoside itching-relieve skin-care reveals and preparation method thereof.
Background technology
Floral water and perfume, GULONG water etc. belong to perfume class cosmetics, and to be only its spice different with ethanol content from both differences rear.Floral water is generally used as the summertime hygienic article of Eradicates except fetid sweat, develop at present the floral water that many Chinese herbal medicine or animal organ's (as Fel Serpentis) are body material, outside the original effect of floral water, expanded anophelifuge, antibacterial, kill the function such as demodicid mite, children special-purpose.Although, now floral water is commercially more, but be no lack of the nutritional labeling of artificial chemistry synthesis in its composition, also containing some zests, additive, unsafe composition, as anophelifuge amine (DEET), indalone (Indalon) etc., these compound life-time service, can damage skin, and easily cause irritated grade for untoward reaction.Therefore, need to develop a kind of novel floral water, can play antiallergic antiinflammatory, mosquito-expelling and antipruritic, refreshment, the regeneration of promotion Skin Cell and anti-ageing skin-protecting function of waiting for a long time, and give full play to its green natural plant characteristic, use safety, has no side effect.
Chinese medicine classical documents record, Gardenia Ellis Rubiaceae, it is cold in nature, the micro-acid of taste and bitter, nontoxic, begins to be loaded among Shennong's Herbal; Cure mainly clearing away heat-damp and promoting diuresis, the removing toxic substances of Cool blood, aphtha of the mouth and tongue, pathogenic fire,toxin and furuncles, sprain and swell and ache.In traditional therapy, except it is decocted soup for oral administration except, in addition it is smashed to pieces, is in harmonious proportion external application with Oleum Sesami, treatment scald; Mix external application with Herba Taraxaci, Flos Lonicerae etc., treatment skin infection swells and ache; Be in harmonious proportion containing it with whitish honey, treatment aphtha, laryngopharynx swelling and pain; External application is in harmonious proportion, treatment erysipelas poison etc. with water.
More deep research is had in recent years to the pharmacological action of gardenoside.Gardenoside belongs to iridoid glycoside, and it can clearing away heat-fire, hepatic cholagogic, anti-inflammation.Be widely used in fields such as plant promoter, biological detection agent and bio-carriers (Li Baohua: the research overview [J] of Fructus Gardeniae, time precious traditional Chinese medical science traditional Chinese medicines, 2004.1.5. (6): 370-371).Gardenoside also has significant antiinflammatory, anti-allergic effects, it can suppress various dermatophytes, kill leptospira and schistosomicide, anti-herpesvirus (HSV), norfloxacin (that Sha etc. are better than to the treatment of staphylococcus aureus keratitis, Fructus Gardeniae and effective ingredient pharmacological research progress thereof, Chinese Chinese medicine information magazine, 2005.1 (12): 90-92).Test display in addition, the mice auricular concha swelling that gardenoside can suppress dimethylbenzene to cause and formaldehyde-caused toes swelling, to mice, rabbit soft tissue injury, there are obvious therapeutical effect (Cheng Heli, Zhao new people simultaneously, the antiinflammatory action experimentation [J] of gardenoside, Anhui medicine, 2004,8 (3): 167-168).The glycoside unit of gardenoside can suppress the growth of rat leukemia P388 cell, effectively can treat malignant melanoma and benzopyrene, the microbial skin carcinoma of Aspergillus flavus and to skin normal structure fanout free region (Fu Chunsheng etc., the chemical composition of Fructus Gardeniae and pharmacological action, [J], external medicine (plant amedica fascicle), 2004.19 (4): 152-156).Gardenoside can also raise the expression of paddy Guang glycoside peptide peroxidase in the tissue of acute ischemia; good antagonism is played to because of the radical damage in ischemia damaged tissues; gardenoside has good protective effect (Zhang Zhanjun etc. to ultrastructures such as blood capillary, endotheliocyte, neurogliocytes; gardenoside and compatibility thereof treat focal cerebral ischemia rats evaluating drug effect and study on mechanism; [J]; CHINA JOURNAL OF CHINESE MATERIA MEDICA, 2006.3.1 (11): 907-910).With gardenoside as functional raw material, there is the functions such as inhibiting bacteria and diminishing inflammation, antiallergic, anti-Skin Cell sudden change.
The propagation of towel gourd stem juice to people's immortalization epidermis cell has significant facilitation.If it is mixed with cosmetics, the elasticity of skin (contain beautiful, Li Chengbin etc., loofah bleeding sap is studied the active function of human epidermal cell, Chinese Chinese medicine science and technology, 2010,17 (5): 412-413) can be kept.Containing abundant phytohemagglutinin, polysaccharide compound and peroxidase etc. in towel gourd stem juice, these compositions all have anophelifuge, antibacterial, the anti-ageing effect (Liu Hui that waits for a long time, the little equality of Zhu, the Preliminary Determination of antibacterial Related Component in loofah bleeding sap, Hebei Science & Technology Normal College's journal, 2009,23 (3): 24-28).Above-mentioned result of study display, the effect that towel gourd stem juice can play inhibiting bacteria and diminishing inflammation, repair damaging cells, promotes skin metabolism.
The floral water kind of current listing is a lot, and the raw material preparing floral water is numerous, but up to now, there is no a kind of floral water adopting gardenoside and towel gourd stem juice mixed preparing.
Summary of the invention
Object of the present invention will provide a kind of gardenoside itching-relieve skin-care to reveal and preparation method thereof exactly.This itching-relieve skin-care dew adopts towel gourd stem juice and gardenoside as primary raw material, antiallergic antiinflammatory, mosquito-expelling and antipruritic, refreshment, the regeneration of promotion Skin Cell and anti-ageing skin-protecting function of waiting for a long time can be played, and giving full play to its green natural plant characteristic, use safety, has no side effect.
For achieving the above object, a kind of gardenoside itching-relieve skin-care dew provided by the invention, be made up of according to percentage by weight following raw material: gardenoside 0.7 ~ 1%, towel gourd stem juice 25 ~ 30%, propylene glycol 1 ~ 3%, Cremophor RH40 0.5 ~ 1%, MENTHOL 1.5 ~ 2%, Borneolum Syntheticum 0.3 ~ 0.5%, thymol 0.1 ~ 0.3%, Flos Gardeniae essence 1.0 ~ 1.5%, sodium citrate 0.1 ~ 0.3%, surplus is ethanol.
Preferably, a gardenoside itching-relieve skin-care dew, is made up of according to percentage by weight following raw material: gardenoside 0.8%, towel gourd stem juice 30%, propylene glycol 1%, Cremophor RH40 1%, MENTHOL 2%, Borneolum Syntheticum 0.3%, thymol 0.2%, Flos Gardeniae essence 1.5%, sodium citrate 0.2%, ethanol 63%.
Further, described gardenoside adopts fine separation technology to purify.
Further, the concentration of described ethanol is 95%.
Preparation method of the present invention, comprises the steps:
(1) first by towel gourd stem juice with the speed of 1200ml/h respectively by after ultraviolet ray sterilizer and filter, be placed in disinfecting container stand-by;
(2) gardenoside, propylene glycol are dissolved in towel gourd stem juice, stir, obtain solution I;
(3) by Cremophor RH40, MENTHOL, Borneolum Syntheticum, thymol, gardenia compound, add in ethanol in proper amount, stir, obtain solution II;
(4) solution I is slowly added in solution II, constantly stir, complete Homogeneous phase mixing, obtain solution III;
(5) sodium citrate and remaining ethanol are added in solution III, mix homogeneously, regulate pH to be 6.0 ~ 6.5, obtain solution IV;
(6) solution IV is sealed, still aging more than 48h, be refrigerated to less than 10 DEG C, filter;
(7) quality inspection, subpackage.
Further, in described step (1), the preparation method of towel gourd stem juice is: choose thick strong large Ramulus Luffae, cut off in liftoff 0.8 ~ 1.2 meter of, after the rattan fracture of near end is carried out clean, insert in clean container bottle, obtain from Ramulus Luffae, ooze drop juice out, be towel gourd stem juice.
Further, the filter element aperture of described step (1) middle filtrator is 0.2 ~ 0.5 μm.
The invention has the advantages that:
1, the present invention adopts gardenoside and towel gourd stem juice as main function raw material, can give full play to its green natural characteristic, its antiallergic antiinflammatory outstanding, mosquito-expelling and antipruritic, refreshment, the regeneration of promotion Skin Cell and anti-ageing skin-protecting function of waiting for a long time.
2, do not adopt other water sources as water-soluble solvent in the present invention, cost-saved, decreasing pollution link and preparation technology's procedure links.
3, the Cremophor RH40 that the present invention selects is the castor oil products of modification, easily decompose at nature, noresidue, it is as a kind of efficient solubilizing agents, the surface tension of the medium oil material of cream for skin care can be reduced, make the Homogeneous phase mixing such as the water-soluble substances in water miscible gardenoside and towel gourd stem juice and fat-soluble MENTHOL, essence, ensure that quality of the present invention.
4, the propylene glycol selected of the present invention, is efficient emulsifying agent, gardenoside and towel gourd stem juice can be made to be dispersed in the ethanol of high alcoholic degree; Meanwhile, propylene glycol is also efficient moisture-retention agent, when high alcoholic degree floral water uses, epidermis can be made to still have the water layer of thin layer to cover, and seems soft smooth, unlikely dry and astringent sluggish.
5, the MENTHOL selected of the present invention, can improve the sensory effects of floral water, make people have the sense of antipruritic relieving restlessness, refrigerant frankness after using; MENTHOL is fabulous cutaneous permeable agent simultaneously, and it acts on horny layer of epidermis, can impel cells of superficial layer gap enlargement, reduces skin to the retardation of external skin protection compound, promotes the Transdermal absorption of some active substances; Itself and propylene glycol with the use of, propylene glycol also has Penetration enhance, and it is subcutaneous that both can guide the active component in gardenoside and towel gourd stem juice to infiltrate better jointly, strengthens skin-protecting function.
6, the thymol selected of the present invention, its sterilizing ability is strong, and toxicity is low, can treat dermatophytosis, as component of the present invention, can strengthen the effects such as antibacterial, Eradicates pox.
7, the sodium citrate selected of the present invention, except for except regulating the pH of solution, itself or excellent chelating agent, in floral water, some metal ions can induce aromatic substance generation oxidation reaction, have a great impact the fragrance of product; And sodium citrate can generate stable sequestration thing with these metal ions, ensure that product fragrance is stablized.
8, the present invention contains ethanol, strong to the membrane permeability power of antibacterial, and ethanol can infiltrate among the cell membrane of antibacterial, protoplasm and nucleus, and its histone of quick solidification, plays the effect of kill bacteria.
9, the raw material that the present invention is used is all nontoxic, has no side effect, and safe and feasible meets cosmetics manufacture requirements completely.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is described in further detail:
Embodiment 1:
A gardenoside itching-relieve skin-care dew, is made up of according to percentage by weight following raw material: gardenoside 0.7%, towel gourd stem juice 25%, propylene glycol 1%, Cremophor RH40 0.5%, MENTHOL 1.5%, Borneolum Syntheticum 0.2%, thymol 0.1%, Flos Gardeniae essence 1%, sodium citrate 0.1%, ethanol 69.9%.
Preparation method of the present invention:
(1), after first the towel gourd stem juice of 25% being the filter of 0.2 μm with the speed of 1200ml/h respectively by ultraviolet ray sterilizer and filter element aperture, disinfecting container is placed in stand-by;
(2) gardenoside of 0.7%, the propylene glycol of 1% are dissolved in the towel gourd stem juice of 25%, stir, obtain solution I;
(3) by the Cremophor RH40 of 0.5%, the MENTHOL of 1.5%, Borneolum Syntheticum, the thymol of 0.1%, the gardenia compound of 1% of 0.2%, add in the ethanol of 10%, stir, obtain solution II;
(4) solution I is slowly added in solution II, constantly stir, complete Homogeneous phase mixing, obtain solution III;
(5) ethanol of the sodium citrate of 0.1% and remaining 59.9% is added in solution III, mix homogeneously, regulate pH to be 6.2, obtain solution IV;
(6) solution IV is sealed, still aging more than 48h, be refrigerated to less than 10 DEG C, filter;
(7) quality inspection, subpackage.
Cutaneous safety is tested: implement about Skin Irritation Test relevant regulations in this experimental evidence " safety evaluation of cosmetics progresses and methods " (GB7919-87).The healthy men and women 60 of Stochastic choice, experimenter to ethanol and medical proof fabric without allergies.First cleaning with clear water from ancon 4cm place forearm on the left of volunteer wipes dry, then gets that 2.5 × 2.5cm is foursquare fully to be soaked into this product but not descend that the gauze piece of drop of liquid is smooth to be spread on skin, covers with one deck oilpaper, then pastes with medical proof fabric and fix.Open gauze after 2h, observe change of skin, carry out assay according to table 1 skin wound repair evaluation criterion, result of the test is in table 2.
Table 1 skin wound repair evaluation criterion
| Diagram | |
| (1) erythema is formed | |
| Without erythema | - |
| Visible erythema reluctantly | ± |
| Obvious erythema | + |
| Moderate erythema | ++ |
| Aubergine erythema also has eschar to be formed | +++ |
| (2) edema is formed | |
| Without edema | - |
| Visible edema reluctantly | ± |
| Cutaneous protuberance profile is clear | + |
| Edema swells about 1mm | ++ |
| Edema is swelled more than 1mm, expanded range | +++ |
Table 2 gardenoside itch-stopping dew skin wound repair result
| Total tested number | - | ± | + | ++ | +++ | Positive rate % | |
| Erythema forms number | 60 | 57 | 2 | 1 | 0 | 0 | 5.0％ |
| Edema forms number | 60 | 58 | 2 | 0 | 0 | 0 | 3.3％ |
Above-mentioned result of the test shows, the safety of the present invention to skin is excellent.
Embodiment 2:
A gardenoside itching-relieve skin-care dew, is made up of according to percentage by weight following raw material: gardenoside 0.8%, towel gourd stem juice 30%, propylene glycol 1%, Cremophor RH40 1%, MENTHOL 2%, Borneolum Syntheticum 0.3%, thymol 0.2%, Flos Gardeniae essence 1.5%, sodium citrate 0.2%, ethanol 63%.
Preparation method of the present invention:
(1), after first the towel gourd stem juice of 30% being the filter of 0.2 μm with the speed of 1200ml/h respectively by ultraviolet ray sterilizer and filter element aperture, disinfecting container is placed in stand-by;
(2) gardenoside of 0.8%, the propylene glycol of 1% are dissolved in the towel gourd stem juice of 30%, stir, obtain solution I;
(3) by the Cremophor RH40 of 1%, the MENTHOL of 2%, Borneolum Syntheticum, the thymol of 0.2%, the gardenia compound of 1.5% of 0.3%, add in the ethanol of 15%, stir, obtain solution II;
(4) solution I is slowly added in solution II, constantly stir, complete Homogeneous phase mixing, obtain solution III;
(5) ethanol of the sodium citrate of 0.2% and remaining 48% is added in solution III, mix homogeneously, regulate pH to be 6.5, obtain solution IV;
(6) solution IV is sealed, still aging more than 48h, be refrigerated to less than 10 DEG C, filter;
(7) quality inspection, subpackage.
Itching-relieving action is tested: get mice 50, and male female half and half, be divided into 5 groups at random, i.e. dosage group, gardenoside itch-stopping dew high dose group and essential balm group in matched group, gardenoside itch-stopping dew low dose group, gardenoside itch-stopping dew.This experiment normal saline reagent as a control group.The dosage of basic, normal, high dosage group gardenoside itch-stopping dew, is decided to be high dose concentration with concentration of the present invention (100%), then with normal saline two-fold dilution, produces 50% (middle dosage) and 25% (low dosage) isoconcentration.
First day by right back for mice instep unhairing, and evenly abrades instep with coarse sandpaper and shaves hair place 1cm
2.Within second day, embrocate various dose itch-stopping dew, normal saline or essential balm respectively at wound surface place, mice instep, the amount of embrocating is 0.5ml/ at every turn.Every day 3 times, embrocate 7 times altogether.After last embrocates 30min, drip histamine phosphate normal saline solution to mice instep wound surface, then increase progressively histamine phosphate normal saline solution concentration every 3min.Its concentration is respectively 0.01%, 0.02%, 0.03%, 0.04% and increases progressively successively, and concentration increases by 0.01% at every turn, each dripping quantity 0.05ml, to mice later licks right back foot.The total amount of computation organization's amine, causes as of the present invention valve of itching; Compare with blank group, carry out group difference analysis, itching-relieving action result of the test is in table 3.
Table 3 gardenoside itch-stopping dew on histamine to the impact of mice pruritus
| Group | Embrocate dosage (ml/ time) | Mice quantity/only | Histamine causes the valve dosage/μ g that itches |
| Matched group | 0.5×7 | 10 | 25.42±7.33 |
| Low dosage gardenoside itch-stopping dew group | 0.5×7 | 10 | 40.75±3.24＊ |
| Middle dosage gardenoside itch-stopping dew group | 0.5×7 | 10 | 60.98±9.92＊＊ |
| High dose gardenoside itch-stopping dew group | 0.5×7 | 10 | 84.44±17.74＊＊ |
| Essential balm group | 0.5×7 | 10 | 74.28±15.73＊＊ |
Compare with matched group: * is P < 0.05, * * is P < 0.01
Research shows, histamine is a kind of important mediator that can cause skin pruritus.Mice is in normal circumstances by after antigenic stimulus, and the feature of its skin lesion, pathology and immunity etc. is consistent with mankind's dystopy skin lesion.Above-mentioned experimental result shows, the skin pruritus that essential balm and itch-stopping dew of the present invention all can suppress histamine phosphate to cause effectively, and the present invention is more better than the itching-relieving action of essential balm.
Embodiment 3:
A gardenoside itching-relieve skin-care dew, is made up of according to percentage by weight following raw material: gardenoside 1%, towel gourd stem juice 28%, propylene glycol 3%, Cremophor RH40 0.5%, MENTHOL 1.5%, Borneolum Syntheticum 0.5%, thymol 0.3%, Flos Gardeniae essence 1%, sodium citrate 0.3%, ethanol 63.9%.
Preparation method of the present invention:
(1), after first the towel gourd stem juice of 28% being the filter of 0.5 μm with the speed of 1200ml/h respectively by ultraviolet ray sterilizer and filter element aperture, disinfecting container is placed in stand-by;
(2) gardenoside of 1%, the propylene glycol of 3% are dissolved in the towel gourd stem juice of 28%, stir, obtain solution I;
(3) by the Cremophor RH40 of 0.5%, the MENTHOL of 1.5%, Borneolum Syntheticum, the thymol of 0.3%, the gardenia compound of 1% of 0.5%, add in the ethanol of 20%, stir, obtain solution II;
(4) solution I is slowly added in solution II, constantly stir, complete Homogeneous phase mixing, obtain solution III;
(5) ethanol of the sodium citrate of 0.3% and remaining 43.9% is added in solution III, mix homogeneously, regulate pH to be 6.2, obtain solution IV;
(6) solution IV is sealed, still aging more than 48h, be refrigerated to less than 10 DEG C, filter;
(7) quality inspection, subpackage.
Quality inspection measures:
1, Determination of Gardenoside Content measures: by the Pharmacopoeia of the People's Republic of China, version I portion in 2010 measures Determination of Gardenoside Content of the present invention about technology of Gardenoside from Gardenia jasminoides content assaying method, and measurement result is labelled amount ± 5%.
2, physical behavior inspection: product colour of the present invention is light yellow, and clear liquid is homogeneous, has Flos Gardeniae delicate fragrance.Be coated on skin and have nice and cool brisk sense.
3, health chemical testing: lead, hydrargyrum, arsenic are no more than " cosmetics health specification " required standard that Ministry of Public Health is issued.
Embodiment 4:
A gardenoside itching-relieve skin-care dew, is made up of according to percentage by weight following raw material: gardenoside 0.7%, towel gourd stem juice 28%, propylene glycol 1%, Cremophor RH40 0.8%, MENTHOL 2%, Borneolum Syntheticum 0.3%, thymol 0.2%, Flos Gardeniae essence 1.2%, sodium citrate 0.1%, ethanol 65.7%.
Preparation method of the present invention:
(1), after first the towel gourd stem juice of 28% being the filter of 0.2 μm with the speed of 1200ml/h respectively by ultraviolet ray sterilizer and filter element aperture, disinfecting container is placed in stand-by;
(2) gardenoside of 0.7%, the propylene glycol of 1% are dissolved in the towel gourd stem juice of 28%, stir, obtain solution I;
(3) by the Cremophor RH40 of 0.8%, the MENTHOL of 2%, Borneolum Syntheticum, the thymol of 0.2%, the gardenia compound of 1.2% of 0.3%, add in the ethanol of 25%, stir, obtain solution II;
(4) solution I is slowly added in solution II, constantly stir, complete Homogeneous phase mixing, obtain solution III;
(5) ethanol of the sodium citrate of 0.1% and remaining 40.7% is added in solution III, mix homogeneously, regulate pH to be 6.2, obtain solution IV;
(6) solution IV is sealed, still aging more than 48h, be refrigerated to less than 10 DEG C, filter;
(7) quality inspection, subpackage.
Quality inspection measures:
1, toxicology test: repeatedly Skin Irritation Test, acute ocular irritation test meet national standard;
2, packing instructions: meet country about the relevant regulations such as " cosmetics inspection rule (QB/T1684) ", " cosmetic product packaging external appearance requires (QB/T1685) " and " Metrolgy Inspection of Products in Prepackages rule (JJF1070-2000) ", the packaging material of direct contact product are accomplished nontoxic, aseptic.
The content that this description is not described in detail belongs to the known prior art of professional and technical personnel in the field.
Claims (7)
1. a gardenoside itching-relieve skin-care dew, it is characterized in that, be made up of according to percentage by weight following raw material: gardenoside 0.7 ~ 1%, towel gourd stem juice 25 ~ 30%, propylene glycol 1 ~ 3%, Cremophor RH40 0.5 ~ 1%, MENTHOL 1.5 ~ 2%, Borneolum Syntheticum 0.3 ~ 0.5%, thymol 0.1 ~ 0.3%, Flos Gardeniae essence 1.0 ~ 1.5%, sodium citrate 0.1 ~ 0.3%, surplus is ethanol.
2. gardenoside itching-relieve skin-care dew according to claim 1, it is characterized in that, be made up of according to percentage by weight following raw material: gardenoside 0.8%, towel gourd stem juice 30%, propylene glycol 1%, Cremophor RH40 1%, MENTHOL 2%, Borneolum Syntheticum 0.3%, thymol 0.2%, Flos Gardeniae essence 1.5%, sodium citrate 0.2%, ethanol 63%.
3. gardenoside itching-relieve skin-care dew according to claim 1 and 2, is characterized in that, described gardenoside adopts fine separation technology to purify.
4. gardenoside itching-relieve skin-care dew according to claim 1 and 2, it is characterized in that, the concentration of described ethanol is 95%.
5. prepare a method for gardenoside itching-relieve skin-care according to claim 1 dew, it is characterized in that, comprise the steps:
(1) first by towel gourd stem juice with the speed of 1200ml/h respectively by after ultraviolet ray sterilizer and filter, be placed in disinfecting container stand-by;
(2) gardenoside, propylene glycol are dissolved in towel gourd stem juice, stir, obtain solution I;
(3) by Cremophor RH40, MENTHOL, Borneolum Syntheticum, thymol, gardenia compound, add in ethanol in proper amount, stir, obtain solution II;
(4) solution I is slowly added in solution II, constantly stir, complete Homogeneous phase mixing, obtain solution III;
(5) sodium citrate and remaining ethanol are added in solution III, mix homogeneously, regulate pH to be 6.0 ~ 6.5, obtain solution IV;
(6) solution IV is sealed, still aging more than 48h, be refrigerated to less than 10 DEG C, filter;
(7) quality inspection, subpackage.
6. the method preparing gardenoside itching-relieve skin-care dew according to claim 5, it is characterized in that, in described step (1), the preparation method of towel gourd stem juice is: choose thick strong large Ramulus Luffae, cut off in liftoff 0.8 ~ 1.2 meter of, after the rattan fracture of near end is carried out clean, insert in clean container bottle, obtain and ooze drop juice out from Ramulus Luffae, be towel gourd stem juice.
7. the method preparing gardenoside itching-relieve skin-care dew according to claim 5, it is characterized in that, the filter element aperture of described step (1) middle filtrator is 0.2 ~ 0.5 μm.
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| CN105411900A (en) * | 2015-11-26 | 2016-03-23 | 澳宝化妆品（惠州）有限公司 | Leontopodium-alpinum-extract-containing skin caring essence and preparing method thereof |
| CN120142533A (en) * | 2025-05-14 | 2025-06-13 | 山东省食品药品检验研究院 | A polycyclic aromatic hydrocarbons detection method based on deep eutectic solvent extraction |
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