CN105055080A - Corneal endothelial cell scraper - Google Patents
Corneal endothelial cell scraper Download PDFInfo
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- CN105055080A CN105055080A CN201510483963.6A CN201510483963A CN105055080A CN 105055080 A CN105055080 A CN 105055080A CN 201510483963 A CN201510483963 A CN 201510483963A CN 105055080 A CN105055080 A CN 105055080A
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- endothelial cell
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- cell scraper
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Abstract
The invention discloses a corneal endothelial cell scraper. The corneal endothelial cell scraper comprises a scraping scoop, a handle and a plurality of channels. The scraping scoop comprises a scoop body and a scoop tip which are connected. The scoop body is connected with the head of the handle. The scoop tip is provided with an outlet and a microscopy scraping table. The microscopy scraping table is used for scraping corneal endothelial cells. The channels are formed inside the handle and the scraping scoop, the head ends of the channels are communicated with the outlet of the scoop tip, and inlets are formed in the tail ends of the channels. According to the corneal endothelial cell scraper, as the more than one channel is formed inside the handle and the scraping scoop, and gas or liquid required by scraping the corneal endothelial cells can be injected through the channels when the corneal endothelial cells are scraped through the scraper, gas adding or liquid adding assisting apparatuses are omitted, and the operation complexity is reduced.
Description
Technical field
The present invention relates to medical instruments field, particularly a kind of endothelial cell scraper.
Background technology
Human corneal can be divided into 5 layers, and innermost layer is corneal endothelial layer, is made up of the hexagon endothelial cell of monolayer.The physiological function of endothelial cell has: (1), by the effect of sodiumpotassium pump, maintains corneal osmosis pressure; (2) by the composite joint between endothelial cell, the barrier action between corneal stroma and aqueous humor is served.
Because the active liquid pump effect of endothelial cell and barrier function ensure that the transparency of cornea and normal thickness, therefore once endothelial cell is impaired, or density declines, and will cause irreversible disease.The disease of these corneal endotheliums infringement comprises: the endothelium that the Endotheliitis of the congenital corneal endothelial lesions such as corneal endothelial dystrophy, recurrent exerbation, glaucoma durative intraocular hypertension, endophthalmitis and multiple intraocular surgery cause loses compensatory.
For keratopathy, at present at drug treatment, ROCK signal transduction pathway may be used to suppress.ROCK signal transduction pathway inhibitor is a kind of serine/threonine kinases, has the effect of repairing endotheliocyte in rabbit, monkey corneal injury model.Before use ROCK signal transduction pathway inhibitor for treating, need the endothelial cell removing disease damage, vacate position and be beneficial to normal cell regeneration, then repair lesional area.
The method for building up of current modal corneal endothelium damage model has: cornea cryolesion, supersound method, scrape division etc.When division is scraped in use, due in current prior art, there is no the apparatus being exclusively used in and striking off endothelial cell.And existing Tweezers for eye surgery need coordinate other instrumentations when for striking off endothelial cell, and the tweezer nose part of Tweezers for eye surgery also not with the form fit of corneal endothelium, therefore have and strike off inefficiency, strike off inconvenience, the shortcomings such as other parts of easy damaged ophthalmic.
Summary of the invention
The object of the present invention is to provide a kind of endothelial cell scraper, this endothelial cell scraper be easy to use, handling safety, simultaneously corneal endothelial is little, can also save auxiliary aerating or liquid feeding apparatus, reduces operation complexity.
For solving the problems of the technologies described above, embodiments of the present invention provide a kind of endothelial cell scraper, comprise and strike off spoon, handle and some passages.Strike off spoon and comprise interconnective spoon body and spoon point, spoon body is connected with the head of handle, and spoon point is provided with and exports and micro-ly strike off platform, and the micro-platform that strikes off is for striking off endothelial cell; Handle inner and strike off spoon inside formed passage, the head end of passage and the outlet of spoon point, afterbody end formed import.
In terms of existing technologies, the present invention passes through at handle inner and strikes off at least one passage of spoon inside formation, when using this scraper to strike off endothelial cell, this passage may be used for injecting and strikes off gas needed for endothelial cell or liquid, and then save auxiliary aerating or liquid feeding apparatus, reduce operation complexity.
As preferably, passage is two or more, at least comprises an air guide channel and a liquid-conveying ducts; The afterbody end of air guide channel forms air inlet, and the afterbody end of liquid-conveying ducts forms inlet.The gas that air guide channel passes into is for maintaining anterior chamber depth when striking off; The endothelial cell chip that the liquid that liquid-conveying ducts passes into strikes off for auxiliary flush.
Further, as preferably, endothelial cell scraper also comprises airway, and the head end of airway is connected with air inlet; The afterbody end of airway forms two intake interfaces, is respectively the first intake interface and the second intake interface; First intake interface is used for passing into disinfecting air, and the second intake interface is used for passing into noble gas, and inlet is used for passing into balanced salt solution or heparin suspension.The gas that air guide channel passes into is for while maintaining anterior chamber depth when striking off, and corneal endothelium carries out disinfection, and avoids the infection to the endothelial cell struck off in operating process.
In addition, as preferably, spoon point comprises upper surface and lower surface, and the micro-platform that strikes off is positioned at upper surface, and spoon body bends towards the direction of court of upper surface institute.Bending spoon body is for straight spoon body, and spoon point is easier touches endothelial cell layer after stretching into ophthalmic.
Further, as preferably, spoon body bends to arc.The flowing of the fluid in its inner passage is more unobstructed, and the pressure at each position is also more balanced, therefore more difficultly injures eye.
In addition, as preferably, export identical with the quantity of passage, and each outlet and each passage one_to_one corresponding.Respectively for the outlet that different channel settings is different, can cross-contamination in an efficient way between passage.
Further, as preferably, when outlet is identical with the quantity of passage, and when each outlet and each passage one_to_one corresponding, an air guide channel and a liquid-conveying ducts can in passage, at least be comprised.The afterbody end of air guide channel forms air inlet, and the afterbody end of liquid-conveying ducts forms inlet.Outlet at least comprises a gas outlet and liquid outlet, and gas outlet is communicated with the head end of air guide channel, and liquid outlet is communicated with the head end of liquid-conveying ducts.Now, liquid outlet is positioned at the upper surface of spoon point, and liquid outlet is positioned at and micro-ly strikes off the avris of platform near handle orientations, and gas outlet is then positioned at lower surface.The gas that air guide channel passes into for maintaining anterior chamber depth when striking off, the corneal endothelium chip that the liquid that liquid-conveying ducts passes into strikes off for auxiliary flush.
As preferably, micro-ly strike off the outwardly protruding of platform.The protruding micro-platform that strikes off can contact with endothelial cell more fully, and prevents other positions and the Corneal Contact of spoon part, causes scuffing.
As preferably, in passage, be provided with one-way cock.One-way cock can prevent inner fluid passage from flowing backwards, thus keeps intraocular pressure.
As preferably, the micro-surface-coated striking off platform has nano coating, utilizes nano coating can strengthen coating effect.
Accompanying drawing explanation
Fig. 1 is schematic diagram when establishing a passage in endothelial cell scraper of the present invention;
Fig. 2 be endothelial cell scraper of the present invention strike off spoon spoon point upper surface schematic diagram;
Fig. 3 is schematic diagram when establishing two passes in endothelial cell scraper of the present invention;
Fig. 4 be endothelial cell scraper of the present invention strike off spoon spoon point lower surface schematic diagram;
Fig. 5 is the schematic diagram that endothelial cell scraper of the present invention strikes off spoon.
Wherein, 1 is spoon point, and 2 is spoon body, and 3 is handle, and 4 is passage, and 41 is liquid-conveying ducts, and 42 is air guide channel, and 5 is import, and 51 is inlet, and 52 is the first intake interface, and 53 is the second intake interface, and 6 is the micro-platform that strikes off, and 7 is liquid outlet, and 8 is gas outlet.
Detailed description of the invention
For making the object, technical solutions and advantages of the present invention clearly, below in conjunction with accompanying drawing, the embodiments of the present invention are explained in detail.But, persons of ordinary skill in the art may appreciate that in each embodiment of the present invention, proposing many ins and outs to make reader understand the application better.But, even without these ins and outs with based on the many variations of following embodiment and amendment, each claim of the application technical scheme required for protection also can be realized.
First embodiment of the present invention relates to a kind of endothelial cell scraper, and shown in composition graphs 1, this endothelial cell scraper comprises and strikes off spoon, handle 3 and a passage 4; Strike off spoon and comprise interconnective spoon body 2 and spoon point 1, spoon body 2 is connected with the head of handle 3, and shown in composition graphs 2, spoon point 1 is provided with outlet and micro-ly strikes off platform 6, and the micro-platform 6 that strikes off is for striking off endothelial cell; Handle 3 is inner and strike off spoon inside formation passage 4, and the head end of passage 4 and the outlet of spoon point 1, afterbody end forms import 5.
In present embodiment, when using this scraper to strike off endothelial cell, passage 4 may be used for injecting and strikes off gas required for endothelial cell or liquid, and then saves auxiliary aerating or liquid feeding apparatus, reduces operation complexity.
Specifically, hereafter will be used for for this passage 4 annotating gas the situation applied in Rhizoma Atractylodis Macrocephalae, and the actual application of this scraper is described:
In the scraping operation of endothelial cell, following flow process can be had:
(1) eyeball is done to the cut-out of limbus corneae of 1.5mm, then the part of this endothelial cell scraper spoon point 1 is stretched into anterior chamber.
(2) pass into disinfecting air by passage 4 to corneal endothelium region, keep a period of time (being usually about 10 minutes), now, generation loosens by endothelial cell.Meanwhile, reverse headgear pipe can be utilized in anterior chamber, to inject appropriate liquid (can be balanced salt solution or heparin suspension) to maintain intraocular pressure.
(3) by spoon point 1, endotheliocyte is struck off.When striking off endothelial cell, because endothelial cell layer loosens, therefore not easily scrape entocornea by mistake, thus after cornea, substrate bed extends when preventing endothelial cell from regenerating.
After endothelial cell loosens, also this passage 4 can be converted as fluid passage 4, thus save reverse headgear pipe, the liquid passed into is also for washing away by the endothelial cell that scrapes and chip thereof.
In the present embodiment, one-way cock (one-way cock does not illustrate in the drawings) is provided with in passage 4.One-way cock can prevent ocular fluids from flowing backwards, thus keeps intraocular pressure.Wherein, it is inner that one-way cock can be arranged on passage 4, and also can be located at import 5 place of passage 4, furthermore, when passage 4 extension has conduit, this one-way cock also can be located in conduit.Its concrete setting position does not affect the realization of the basic object of the present invention.
In the present embodiment, the micro-surface-coated striking off platform 6 has nano coating.This nano coating can be metal nano coating, also can be ceramic nano coating.Select metal nano coating to have to be easy to and manufacture and the advantage of processing, and during Ceramics nano coating, its human body affinity is better, and there is better stability.The size of nano coating can variation near 0.8 × 0.6 millimeter, can select different specifications according to different operation demands.
In the present embodiment, the size striking off spoon is advisable with 30G, for curettage, selects the spoon utensil of striking off of 30G to have good matching.
In the present embodiment, the outer surface of handle 3 forms roughness, and roughness, for increasing frictional force during gripping handle 3, because frictional force is less when avoiding gripping handle 3, grips and tightly do not make handle 3 skid, impact operation.Specifically, this roughness can adopt screw thread, also can adopt rough rough surface.
Second embodiment of the present invention relates to a kind of endothelial cell scraper.Second embodiment is the further improvement based on the first embodiment, and main improvements are: in second embodiment of the invention, and spoon point 1 comprises upper surface and lower surface.Shown in composition graphs 2 and Fig. 5, the micro-platform 6 that strikes off is positioned at upper surface, and spoon body 2 bends towards the direction of court of upper surface institute.
Because the direction of spoon body 2 towards court of upper surface institute bends, therefore for straight spoon body 2, spoon point 1 is easier touches endothelial cell layer after stretching into ophthalmic.Now, the micro-platform 6 that strikes off being positioned at spoon point 1 upper surface more easily touches cornea inwall, and its abrading process is more laborsaving.
In the present embodiment, this bending shape can be L shape, and its manufacturing process is simple, strikes off also very convenient.But further, spoon body 2 also can bend to arc.Strike off spoon relative to L shape, the flowing of the fluid in its inner passage 4 is more unobstructed, and the pressure at each position is also more balanced, therefore more difficultly injures eye, and, to the cleaning of curved channel 4 also more for convenience.Specifically, the radian of this arc between 115 ° to 125 °, can most preferably be 120 °.The spoon body 2 of this arc range can more convenient spoon point 1 and cornea contact internal walls.
3rd embodiment of the present invention relates to a kind of endothelial cell scraper.3rd embodiment is on the basis of the second embodiment, done further improvement, and main improvements are: in third embodiment of the invention, have at least 3 passages.These three passages comprise two air guide channels and a liquid-conveying ducts.The afterbody end of this air guide channel forms two air inlets respectively, and the afterbody end of liquid-conveying ducts forms an inlet; This air inlet is respectively used to pass into disinfecting air and noble gas, and inlet is then for passing into balanced salt solution or heparin suspension.
In the present embodiment, these passages can converge to an outlet jointly, also can be respectively equipped with corresponding outlet.Relative to only arranging for an outlet, respectively for the outlet that different channel settings is different, can cross-contamination in an efficient way between passage.Therefore, in the present embodiment, outlet is also 3, and each outlet and each passage one_to_one corresponding.
Specifically, in the present embodiment, the liquid-conveying ducts outlet for passing into liquid is positioned at the upper surface of spoon point 1, and the air guide channel that the air guide channel for passing into noble gas exported and passed into disinfecting air exports the lower surface being then positioned at spoon point 1.
In the scraping operation of endothelial cell, following flow process can be had:
(1) eyeball is done to the cut-out of limbus corneae of 1.5mm, then the part of this endothelial cell scraper spoon point 1 is stretched into anterior chamber, wherein, the upper surface of spoon point 1 is towards corneal endothelium region.
(2) pass into disinfecting air by exporting the air guide channel being positioned at spoon point 1 lower surface to anterior chamber, keep a period of time (being usually about 10 minutes), now, generation loosens by endothelial cell.Then, the air guide channel being positioned at spoon point 1 lower surface by outlet passes into noble gas to camera oculi anterior, passes into balanced salt solution or heparin suspension, to maintain anterior chamber depth and intraocular pressure by liquid-conveying ducts in camera oculi anterior.
(3) by spoon point 1, endotheliocyte is struck off.When striking off endothelial cell, because endothelial cell layer loosens, therefore not easily scrape entocornea by mistake, thus after cornea, substrate bed extends when preventing endothelial cell from regenerating.Further, when striking off endothelial cell, the liquid utilizing liquid-conveying ducts to pass in camera oculi anterior also can simultaneously for washing away by the cell that scrapes and chip thereof.
Thus, according to different user demands, make the outlet of the passage passing into different material all be positioned at desired position, therefore strike off spoon without the need to adjustment in art or upset.Therefore, present embodiment, for the endothelial cell scraper of single channel, eliminates the use of reverse headgear head, reduces operating difficulty, has simplified operating theater instruments, and can effectively prevent from overturning the secondary injury striking off spoon and cause eye.
It is worth mentioning that, in the middle of present embodiment, noble gas can be the rare gas such as helium, argon, can be more perfluoropropane gas, is wherein good with the perfluoropropane gas of 18%.
4th embodiment of the present invention relates to a kind of endothelial cell scraper.4th embodiment is on the basis of the 3rd embodiment, done further improvement, and main improvements are: in the 4th embodiment of the present invention, passage is two.Shown in composition graphs 3, wherein, comprise an air guide channel 42 and a liquid-conveying ducts 41, the afterbody end of air guide channel 42 forms air inlet, and the afterbody end of liquid-conveying ducts 41 forms inlet 51.
Relative to three or more quantity passage endothelial cell scraper for, the endothelial cell scraper that present embodiment provides is owing to decreasing number of channels, and the space therefore taken is less, and its volume can be less.Particularly, less in the size at spoon body 2 position of striking off spoon, when carrying out scraping operation, the required wound opened at eyeball surface is also less, therefore lower to the injury of patient.
In the present embodiment, endothelial cell scraper also comprises airway, and the head end of airway is connected with air inlet; The afterbody end of airway forms two intake interfaces, is respectively the first intake interface 52 and the second intake interface 53; First intake interface 52 is for passing into disinfecting air, and the second intake interface 53 is for passing into noble gas, and inlet 51 is for passing into balanced salt solution or heparin suspension.Owing to make use of the airway with two air inlets, although therefore present embodiment only has two passes, still can realize diversion function during three passages simultaneously.
Such as, the first intake interface 52 can pass into disinfecting air, for carrying out disinfection to the endothelial cell struck off.The noble gas that second intake interface 53 passes into, for maintaining the anterior chamber depth of endothelial cell.The balanced salt solution that inlet 51 passes into or heparin suspension, loosen for making endothelial cell and corneal endothelium chip that auxiliary flush is struck off.The first intake interface 52 and the second intake interface 53 that airway is formed, and inlet 51 all adapts to the head of clinical general transfusion and syringe, make by more convenient to operate to injected gas in each passage or liquid of the first intake interface 52 or the second intake interface 53 or inlet 51.
In the respective embodiments described above, the diameter being in air guide channel 42 in spoon body 2 and liquid-conveying ducts 41 can be all 0.3 millimeter.Handle 3 length gripped can reach 8.0 centimetres, and diameter can be 1.0 cm.The diameter being in air guide channel 42 in spoon body 2 and liquid-conveying ducts 41 can be all 3.0 millimeter.Each concrete size slightly can adjust according to the practical situation of different patient above.
5th embodiment of the present invention relates to a kind of endothelial cell scraper.5th embodiment is on the basis of the 4th embodiment, done further improvement, and main improvements are: in fifth embodiment of the invention, shown in composition graphs 2, and the micro-outwardly projection striking off platform 6.The protruding micro-platform 6 that strikes off can contact with endothelial cell more fully, and prevents other positions and Corneal Contact, causes scuffing.
In the present embodiment, the micro-shape striking off platform 6 can be oval plate shape.Also can be the surface of waveform or other shapes.The micro-platform 6 that strikes off of oval dish type is selected to have larger contact area, strike off efficiency higher, and select corrugated surface, the endotheliocyte scraped and chip thereof can be stuck in wave trough position, and shift out ophthalmic along with endothelial cell scraper and be pulled away, and then simplify cleaning course.Obviously, other micro-platform 6 shape of striking off also can realize technical purpose of the present invention substantially.
Furthermore, in the present embodiment, liquid outlet 7 is positioned at the upper surface of spoon point 1, and is positioned at and micro-ly strikes off the avris of platform 6 near handle 3 direction.Shown in composition graphs 4, gas outlet 8 is then positioned at lower surface.
Strike off the injury of spoon to eye to alleviate, spoon point 1 should get over Bao Yuehao.But micro-ly strike off the avris of platform 6 away from handle 3 direction if to be directly arranged at by liquid outlet 7 on spoon point 1 and to make liquid outlet 7 be positioned at, then liquid-conveying ducts 41 necessarily passes spoon point 1, and this increases causing the thickness of spoon point 1.Therefore, preferably, liquid outlet 7 is arranged at this position, has both been convenient to wash away the endothelial cell and chip thereof that come off, can help again to maintain anterior chamber depth.
In addition, can also arrange capillary tube in spoon point 1, be arranged on the micro-table top striking off platform 6 by liquid outlet 7 with the form of multiple little micropore, one end of these capillary tubies is communicated with liquid outlet 7, and the other end is communicated with liquid-conveying ducts.Thus, flushing liquid directly can spray from the micro-platform 6 that strikes off, and its scouring effect is better.
More with furthermore, crumb loading groove can also being set micro-striking off below platform 6, for collecting the cell debris be washed down, thus reducing clean difficulty.
Persons of ordinary skill in the art may appreciate that the respective embodiments described above realize specific embodiments of the invention, and in actual applications, various change can be done to it in the form and details, and without departing from the spirit and scope of the present invention.
Claims (10)
1. an endothelial cell scraper, is characterized in that: comprise and strike off spoon, handle and N bar passage, described N be more than or equal to 1 natural number;
The described spoon that strikes off comprises interconnective spoon body and spoon point, and described spoon body is connected with the head of described handle, and described spoon point is provided with and exports and micro-ly strike off platform, and the described micro-platform that strikes off is for striking off endothelial cell;
Described handle inner and described spoon inside of striking off form passage, the head end of described passage and the outlet of described spoon point, and afterbody end forms import.
2. endothelial cell scraper according to claim 1, is characterized in that: described N is more than or equal to 2;
Described passage at least comprises an air guide channel and a liquid-conveying ducts; The afterbody end of described air guide channel forms air inlet, and the afterbody end of described liquid-conveying ducts forms inlet.
3. endothelial cell scraper according to claim 2, is characterized in that: described endothelial cell scraper also comprises airway, and the head end of described airway is connected with described air inlet;
The afterbody end of described airway forms two intake interfaces, is respectively the first intake interface and the second intake interface;
Described first intake interface is used for passing into disinfecting air, and described second intake interface is used for passing into noble gas, and described inlet is used for passing into balanced salt solution or heparin suspension.
4. endothelial cell scraper according to claim 1, is characterized in that: described outlet is M, and described M equals described N, and each outlet and each passage one_to_one corresponding.
5. endothelial cell scraper according to claim 1, is characterized in that: described spoon point comprises upper surface and lower surface, and the described micro-platform that strikes off is positioned at described upper surface, and described spoon body bends towards the direction of court of described upper surface institute.
6. endothelial cell scraper according to claim 5, is characterized in that: described spoon body bends to arc.
7. endothelial cell scraper according to claim 5, is characterized in that: described outlet is M, and described M equals described N, and each outlet and each passage one_to_one corresponding;
Described N is more than or equal to 2, and described passage at least comprises an air guide channel and a liquid-conveying ducts; The afterbody end of described air guide channel forms air inlet, and the afterbody end of described liquid-conveying ducts forms inlet;
Described outlet at least comprises a gas outlet and liquid outlet, and described gas outlet is communicated with the head end of described air guide channel, and described liquid outlet is communicated with the head end of described liquid-conveying ducts;
Described liquid outlet is positioned at described upper surface, and described liquid outlet is positioned at and describedly micro-ly strikes off the avris of platform near described handle orientations; Described gas outlet is positioned at described lower surface.
8. endothelial cell scraper according to claim 1, is characterized in that: the described micro-outwardly projection striking off platform.
9. endothelial cell scraper according to claim 1, is characterized in that: be provided with one-way cock in described passage.
10. endothelial cell scraper according to claim 1, is characterized in that: the described micro-surface-coated striking off platform has nano coating.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510483963.6A CN105055080B (en) | 2015-08-07 | 2015-08-07 | Endothelial cell scaler |
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| CN201510483963.6A CN105055080B (en) | 2015-08-07 | 2015-08-07 | Endothelial cell scaler |
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| CN105055080B CN105055080B (en) | 2017-09-22 |
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| CN201168115Y (en) * | 2008-01-18 | 2008-12-24 | 夏美华 | Remover for foreign body in eye |
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| CN202724100U (en) * | 2012-08-09 | 2013-02-13 | 天津市滨海新区大港医院 | Curette used for ophthalmology |
| CN202724099U (en) * | 2012-08-09 | 2013-02-13 | 天津市滨海新区大港医院 | Curette used for ophthalmology |
| CN204971834U (en) * | 2015-08-07 | 2016-01-20 | 上海市同济医院 | Cornea endothelial cells scaler |
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2015
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5154694A (en) * | 1989-06-06 | 1992-10-13 | Kelman Charles D | Tissue scraper device for medical use |
| CN2933355Y (en) * | 2006-06-02 | 2007-08-15 | 苏州六六视觉科技股份有限公司 | Corneal epithelium dissector |
| EP2005923A1 (en) * | 2007-06-19 | 2008-12-24 | Alcon, Inc. | Apparatus, system and method for illuminated membrane manipulator |
| CN201168115Y (en) * | 2008-01-18 | 2008-12-24 | 夏美华 | Remover for foreign body in eye |
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| CN202724100U (en) * | 2012-08-09 | 2013-02-13 | 天津市滨海新区大港医院 | Curette used for ophthalmology |
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