CN104984368A - Medical ultrasonic coupling agent and preparation method thereof - Google Patents
Medical ultrasonic coupling agent and preparation method thereof Download PDFInfo
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- CN104984368A CN104984368A CN201510372219.9A CN201510372219A CN104984368A CN 104984368 A CN104984368 A CN 104984368A CN 201510372219 A CN201510372219 A CN 201510372219A CN 104984368 A CN104984368 A CN 104984368A
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Abstract
The invention discloses a medical ultrasonic coupling agent and a preparation method thereof. The ultrasonic coupling agent comprises the following raw materials in parts by weight: 5-20 parts of glycerinum, 20-28 parts of lemongrass leaves, 12-18 parts of vitamin E, 0.2-0.7 part of glycerine, 3-14 parts of dendrobium officinale, 0.1-0.5 part of garlic, and 15-28 parts of distilled water. The preparation method comprises the following steps: 1, weighing the raw materials, peeling garlic, cutting the peeled garlic into garlic slices, and cutting the lemongrass leaves into lemongrass sections; 2, mixing the garlic slices, lemongrass sections and dendrobium officinale, crushing and sieving the mixture, so as to obtain a filtrate for standby; adding distilled water of which the weight is 1.5-2 times of the mixture into mixture in the step 2, distilling for 10-15 min to obtain distillate, and pouring the distillate into the filtrate to obtain a first mixed liquor; heating the first mixed liquor to the temperature of 30-40 DEG C, then, adding the glycerinum and glycerine, stirring, spraying the vitamin E, and then, adjusting the pH value to be 7, so as to obtain the medical ultrasonic coupling agent. The medical ultrasonic coupling agent is strong in bactericidal power, good in water solubility and easy to prepare.
Description
Technical field
The invention belongs to medical products field, be specifically related to a kind of medical ultrasonic coupling agent and preparation method thereof.
Background technology
Medical ultrasonic coupling agent is a kind of curable product be made up of aqueous high molecular gel of new generation, it is the entrant sound intermediary medium of extensive use in a kind of medical ultrasonic diagnosis and treatment, promote the coupling between probe and human body skin, isolated air between ultrasonic probe and detected portion skin, acoustic transmission is not decayed, to reach the check result of accurately cleaning by the impact of air.Its pH value is neutral, harmless to human non-toxic, not easily dry, and not easily become sour, toughness is suitable for, and without greasy, probe is easy to slide, wettable skin, and eliminate skin surface air, lubricity is good, is easy to launch, to ultrasonic probe non-corrosiveness, not damaged.
At present, the medical ultrasonic coupling agent with sterilization formulation is of less types, and composition mostly is chemicals, large to the zest of health, antibacterial persistency and poorly water-soluble, urgent need to research and develop a kind of natural, sterilizing power strong, water-soluble good medical ultrasonic coupling agent.
Summary of the invention
For the deficiencies in the prior art, the object of the present invention is to provide a kind of medical ultrasonic coupling agent and preparation method thereof, this couplant sterilizing ability is strong, and coupling is good, applied range.
For solving prior art problem, the technical scheme that the present invention takes is:
A kind of medical ultrasonic coupling agent, comprises the following raw material counted by weight: glycerol 5-20 part, Herba Cymbopogonis Citrari blade of grass 20-28 part, vitamin E 12-18 part, glycerol 0.2-0.7 part, Herba Dendrobii 3-14 part, Bulbus Allii 0.1-0.5 part, distilled water 15-28 part.
As preferably, above-mentioned medical ultrasonic coupling agent, comprises the following raw material counted by weight: glycerol 12-18 part, Herba Cymbopogonis Citrari blade of grass 22-27 part, vitamin E 15-17 part, glycerol 0.4-0.7 part, Herba Dendrobii 5-12 part, Bulbus Allii 0.2-0.4 part, distilled water 20-26 part.
As the thing improved, above-mentioned medical ultrasonic coupling agent also comprises Radix Scutellariae 12-17 part.
The preparation method of above-mentioned medical ultrasonic coupling agent, comprises the following steps:
Step 1, takes raw material, after garlic peeling, is cut into the Bulbus Allii piece that 1-2cm is thick, and Herba Cymbopogonis Citrari blade of grass is cut into the Herba Cymbopogonis Citrari section of 1-2cm;
Step 2, fragmentation after the mixing of Bulbus Allii piece, Herba Cymbopogonis Citrari section and Herba Dendrobii sieved, filtrate is for subsequent use;
Step 3, adds its weight 1.5-2 distilled water doubly in step 2, and distillation 10-15min obtains distillate, is incorporated in filtrate and obtains the first mixed liquor;
Step 4, is heated to 30-40 DEG C by the first mixed liquor, then adds glycerol and glycerol, stirs 2-5min, after spraying vitamin E, regulates pH to 7 to obtain medical ultrasonic coupling agent.
As preferably, step 3 in the preparation method of above-mentioned medical ultrasonic coupling agent, distills for distilling under reduced pressure.
As preferably, step 4 in the preparation method of above-mentioned medical ultrasonic coupling agent, mixing speed is 340-480rpm.
beneficial effect
Compared with prior art, the medical ultrasonic coupling agent coupling transparency of the present invention is good, has stronger sterilizing ability, good antimicrobial effect, good water solubility, even if account on clothes, easily cleans.In addition, in preparation process, adopt distilling under reduced pressure, effectively protect the antipathogenic composition of couplant, therefore there is good market prospect.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described.Following examples just for performance of the present invention is clearly described, and only can not be confined to the following examples.
embodiment 1
A kind of medical ultrasonic coupling agent, comprises the following raw material counted by weight: glycerol 5 parts, 20 parts, Herba Cymbopogonis Citrari blade of grass, vitamin E 12 parts, glycerol 0.2 part, Herba Dendrobii 3 parts, 0.1 part, Bulbus Allii, distilled water 15 parts.
The preparation method of above-mentioned medical ultrasonic coupling agent, comprises the following steps:
Step 1, takes raw material, after garlic peeling, is cut into the Bulbus Allii piece that 1cm is thick, and Herba Cymbopogonis Citrari blade of grass is cut into the Herba Cymbopogonis Citrari section of 1cm;
Step 2, fragmentation after the mixing of Bulbus Allii piece, Herba Cymbopogonis Citrari section and Herba Dendrobii sieved, filtrate is for subsequent use;
Step 3, adds the distilled water of its weight 1.5 times in step 2, and distillation 10min obtains distillate, is incorporated in filtrate and obtains the first mixed liquor;
Step 4, is heated to 30 DEG C by the first mixed liquor, then adds glycerol and glycerol, stirs 2min with 340rpm, after spraying vitamin E, regulates pH to 7 to obtain medical ultrasonic coupling agent.
embodiment 2
A kind of medical ultrasonic coupling agent, comprises the following raw material counted by weight: glycerol 12-18 part, Herba Cymbopogonis Citrari blade of grass 22-27 part, vitamin E 15-17 part, glycerol 0.4-0.7 part, Herba Dendrobii 5-12 part, Bulbus Allii 0.2-0.4 part, distilled water 20-26 part.
The preparation method of above-mentioned medical ultrasonic coupling agent, comprises the following steps:
Step 1, takes raw material, after garlic peeling, is cut into the Bulbus Allii piece that 1-2cm is thick, and Herba Cymbopogonis Citrari blade of grass is cut into the Herba Cymbopogonis Citrari section of 1-2cm;
Step 2, fragmentation after the mixing of Bulbus Allii piece, Herba Cymbopogonis Citrari section and Herba Dendrobii sieved, filtrate is for subsequent use;
Step 3, in step 2, add its weight 1.5-2 distilled water doubly, distilling under reduced pressure 10-15min obtains distillate, is incorporated in filtrate and obtains the first mixed liquor;
Step 4, is heated to 30-40 DEG C by the first mixed liquor, then adds glycerol and glycerol, and 400rpm stirs 2-5min, after spraying vitamin E, regulates pH to 7 to obtain medical ultrasonic coupling agent.
embodiment 3
A kind of medical ultrasonic coupling agent, comprises the following raw material counted by weight: glycerol 20 parts, 28 parts, Herba Cymbopogonis Citrari blade of grass, vitamin E 18 parts, glycerol 0.7 part, Herba Dendrobii 14 parts, 0.5 part, Bulbus Allii, distilled water 28 parts.
The preparation method of above-mentioned medical ultrasonic coupling agent, comprises the following steps:
Step 1, takes raw material, after garlic peeling, is cut into the Bulbus Allii piece that 2cm is thick, and Herba Cymbopogonis Citrari blade of grass is cut into the Herba Cymbopogonis Citrari section of 2cm;
Step 2, fragmentation after the mixing of Bulbus Allii piece, Herba Cymbopogonis Citrari section and Herba Dendrobii sieved, filtrate is for subsequent use;
Step 3, in step 2, add the distilled water of its weight 2 times, distilling under reduced pressure 15min obtains distillate, is incorporated in filtrate and obtains the first mixed liquor;
Step 4, is heated to 40 DEG C by the first mixed liquor, then adds glycerol and glycerol, stirs 5min with 480rpm, after spraying vitamin E, regulates pH to 7 to obtain medical ultrasonic coupling agent.
embodiment 4
A kind of medical ultrasonic coupling agent, comprises the following raw material counted by weight: glycerol 12-18 part, Herba Cymbopogonis Citrari blade of grass 22-27 part, vitamin E 15-17 part, glycerol 0.4-0.7 part, Herba Dendrobii 5-12 part, Bulbus Allii 0.2-0.4 part, distilled water 20-26 part, Radix Scutellariae 12-17 part.
The preparation method of above-mentioned medical ultrasonic coupling agent, comprises the following steps:
Step 1, takes raw material, after garlic peeling, is cut into the Bulbus Allii piece that 1-2cm is thick, and Herba Cymbopogonis Citrari blade of grass is cut into the Herba Cymbopogonis Citrari section of 1-2cm;
Step 2, fragmentation after the mixing of Bulbus Allii piece, Herba Cymbopogonis Citrari section and Herba Dendrobii sieved, filtrate is for subsequent use;
Step 3, in step 2, add its weight 1.5-2 distilled water doubly, distilling under reduced pressure 10-15min obtains distillate, is incorporated in filtrate and obtains the first mixed liquor;
Step 4, is heated to 30-40 DEG C by the first mixed liquor, then adds glycerol and glycerol, and 400rpm stirs 2-5min, after spraying vitamin E, regulates pH to 7 to obtain medical ultrasonic coupling agent.
comparative example 1
A kind of medical ultrasonic coupling agent, comprises the following raw material counted by weight: glycerol 12-18 part, Herba Cymbopogonis Citrari blade of grass 22-27 part, vitamin E 15-17 part, glycerol 0.4-0.7 part, Herba Dendrobii 5-12 part, Bulbus Allii 0.2-0.4 part, distilled water 20-26 part.
The preparation method of above-mentioned medical ultrasonic coupling agent, comprises the following steps:
Step 1, takes raw material, after garlic peeling, is cut into the Bulbus Allii piece that 1-2cm is thick, and Herba Cymbopogonis Citrari blade of grass is cut into the Herba Cymbopogonis Citrari section of 1-2cm;
Step 2, fragmentation after the mixing of Bulbus Allii piece, Herba Cymbopogonis Citrari section and Herba Dendrobii sieved, filtrate is for subsequent use;
Step 3, adds its weight 1.5-2 distilled water doubly in step 2, and distillation 10-15min obtains distillate, is incorporated in filtrate and obtains the first mixed liquor;
Step 4, is heated to 30-40 DEG C by the first mixed liquor, then adds glycerol and glycerol, and 400rpm stirs 2-5min, after spraying vitamin E, regulates pH to 7 to obtain medical ultrasonic coupling agent.
performance test
Tested by the medical ultrasonic coupling agent of embodiment of the present invention 1-4 and comparative example 1, the data obtained is as shown in the table:
From upper table data, medical ultrasonic coupling agent bactericidal effect of the present invention, the antibacterial time is long, and during Clinical practice, coupling effect is good, and during detection, clear picture is accurate, is applicable to industrialization.
Claims (6)
1. a medical ultrasonic coupling agent, is characterized in that, comprises the following raw material counted by weight: glycerol 5-20 part, Herba Cymbopogonis Citrari blade of grass 20-28 part, vitamin E 12-18 part, glycerol 0.2-0.7 part, Herba Dendrobii 3-14 part, Bulbus Allii 0.1-0.5 part, distilled water 15-28 part.
2. medical ultrasonic coupling agent according to claim 1, is characterized in that, comprises the following raw material counted by weight: glycerol 12-18 part, Herba Cymbopogonis Citrari blade of grass 22-27 part, vitamin E 15-17 part, glycerol 0.4-0.7 part, Herba Dendrobii 5-12 part, Bulbus Allii 0.2-0.4 part, distilled water 20-26 part.
3. medical ultrasonic coupling agent according to claim 1, is characterized in that: also comprise Radix Scutellariae 12-17 part.
4. the preparation method of medical ultrasonic coupling agent according to claim 1, is characterized in that, comprises the following steps:
Step 1, takes raw material, after garlic peeling, is cut into the Bulbus Allii piece that 1-2cm is thick, and Herba Cymbopogonis Citrari blade of grass is cut into the Herba Cymbopogonis Citrari section of 1-2cm;
Step 2, fragmentation after the mixing of Bulbus Allii piece, Herba Cymbopogonis Citrari section and Herba Dendrobii sieved, filtrate is for subsequent use;
Step 3, adds its weight 1.5-2 distilled water doubly in step 2, and distillation 10-15min obtains distillate, is incorporated in filtrate and obtains the first mixed liquor;
Step 4, is heated to 30-40 DEG C by the first mixed liquor, then adds glycerol and glycerol, stirs 2-5min, after spraying vitamin E, regulates pH to 7 to obtain medical ultrasonic coupling agent.
5. the preparation method of medical ultrasonic coupling agent according to claim 4, is characterized in that: step 3, distills for distilling under reduced pressure.
6. the preparation method of medical ultrasonic coupling agent according to claim 4, is characterized in that: step 4, and mixing speed is 340-480rpm.
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| CN201510372219.9A CN104984368A (en) | 2015-06-30 | 2015-06-30 | Medical ultrasonic coupling agent and preparation method thereof |
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| CN201510372219.9A CN104984368A (en) | 2015-06-30 | 2015-06-30 | Medical ultrasonic coupling agent and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105457044A (en) * | 2015-12-23 | 2016-04-06 | 江瑞平 | Coupling agent for B ultrasound |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4886068A (en) * | 1985-07-29 | 1989-12-12 | Kabushiki Kaisha Toshiba | Ultrasonic coupling agent |
| CN102807517A (en) * | 2011-06-02 | 2012-12-05 | 上海科材生物科技有限公司 | Synthesis of garlicin derivatives and preparation method for medical ultrasonic couplant with efficient disinfection function using garlicin derivatives |
| CN103933585A (en) * | 2014-04-24 | 2014-07-23 | 王庆华 | Medical disinfecting ultrasonic couplant and preparation method thereof |
| CN103961327A (en) * | 2013-01-30 | 2014-08-06 | 中国石油天然气股份有限公司 | Medical ultrasonic coupling agent |
-
2015
- 2015-06-30 CN CN201510372219.9A patent/CN104984368A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4886068A (en) * | 1985-07-29 | 1989-12-12 | Kabushiki Kaisha Toshiba | Ultrasonic coupling agent |
| CN102807517A (en) * | 2011-06-02 | 2012-12-05 | 上海科材生物科技有限公司 | Synthesis of garlicin derivatives and preparation method for medical ultrasonic couplant with efficient disinfection function using garlicin derivatives |
| CN103961327A (en) * | 2013-01-30 | 2014-08-06 | 中国石油天然气股份有限公司 | Medical ultrasonic coupling agent |
| CN103933585A (en) * | 2014-04-24 | 2014-07-23 | 王庆华 | Medical disinfecting ultrasonic couplant and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 何伯伟: "《铁皮石斛100问》", 28 February 2015, 中国农业科学技术出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105457044A (en) * | 2015-12-23 | 2016-04-06 | 江瑞平 | Coupling agent for B ultrasound |
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Application publication date: 20151021 |