CN104957777A - Effervescent tablet containing nicotine matter and preparation method of effervescent tablet - Google Patents
Effervescent tablet containing nicotine matter and preparation method of effervescent tablet Download PDFInfo
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- CN104957777A CN104957777A CN201510418426.3A CN201510418426A CN104957777A CN 104957777 A CN104957777 A CN 104957777A CN 201510418426 A CN201510418426 A CN 201510418426A CN 104957777 A CN104957777 A CN 104957777A
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- China
- Prior art keywords
- nicotine
- effervescent tablet
- extract
- mixture
- tablet containing
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- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F47/00—Smokers' requisites not otherwise provided for
Abstract
The invention provides an effervescent tablet containing nicotine matter and a preparation method of the effervescent tablet. The effervescent tablet containing the nicotine matter comprises an inclusion compound of active ingredient nicotine extract, an effervescent mixture and auxiliary materials. The nicotine extract is tobacco extract or/and a nicotine active ingredient composition. The effervescent mixture is a mixture of acidic ingredient matter and alkaline ingredient matter. The auxiliary materials include but not limited to a binding agent and a lubricating agent. The inclusion compound of the active ingredient nicotine extract and the auxiliary materials are mixed with the acidic ingredient matter and the alkaline ingredient matter respectively to form soft materials, the soft materials are granulated and dried, acidic mixture particles and mixture ingredient particles are obtained, and then the acidic mixture particles and the mixture ingredient particles are evenly mixed and then pressed into tablets and formed.
Description
Technical field
The present invention relates to a kind of effervescent tablet and preparation method thereof technical field.
Background technology
In recent years; sales volume along with conventional tobacco products occurs that stagnation even declines; in addition many states public places in Nan Chong ban on opium-smoking and the opium trade the continuing to increase of dynamics, traditional cigarette market faces larger crisis, not needing to burn and suck and can reduce the substitute of tobacco to human injury in the urgent need to development of new.
Summary of the invention
The object of this invention is to provide a kind ofly does not need to burn and suck, can effectively reduce smoker's injury, can not produce the second-hand-cigarette to surrounding population injury, the effervescent tablet containing nicotine material can alleviating smoker's craving for tobacco and preparation method thereof yet.
Object of the present invention is achieved through the following technical solutions:
Containing the effervescent tablet of nicotine material, it contains the inclusion compound of active component nicotine extract, effervescent mixture and auxiliary material, and described nicotine extract refers to tobacco extract or/and nicotine active component composition; Described effervescent mixture refers to the mixture of acid ingredient material and alkaline components material; Described auxiliary material includes but not limited to adhesive, lubricant.
The inclusion compound of nicotine extract of the present invention to be weight ratio be 0.5% ~ 5% nicotine extract and the inclusion compound that formed of cyclodextrin or resin material inclusion.
Effervescent tablet of the present invention by weight, at least includes bag and thing 8% ~ 10%, acid ingredient material 15% ~ 30%, alkaline components material 20% ~ 40%, appropriate adhesive, the appropriate lubricant of nicotine extract.
The present invention is also added with appropriate excipient in effervescent tablet; Described excipient is one or more in sweetener, aromatic, colouring agent, buffer, diluent, solubilizer, wetting agent.
Alkaline components material of the present invention is one or more the mixture in sodium acid carbonate, sodium carbonate, potash.Described acid ingredient material is one or more the mixture in citric acid, tartaric acid, fumaric acid, malic acid.
Adhesive of the present invention is absolute ethyl alcohol or ethanolic solution.Described lubricant is one or more in microcrystalline cellulose, starch, Macrogol 6000, Macrogol 4000, Sodium Benzoate, alanine, glycine, sodium acetate, dolomol.
The preparation method of the effervescent tablet containing nicotine material of the present invention, that the inclusion compound of tobacco extract and auxiliary material are mixed and made into softwood with acid ingredient material and alkaline components material respectively, granulation respectively, drying, obtain acidic mixed composition granule and alkaline mixt particle, then compression molding after acidic mixed composition granule is mixed with alkaline mixt uniform particles.
The inventive method, in preparation acidic mixed composition granule, alkaline mixt particle and acidic mixed composition granule and alkaline mixt particle mixed process, all can add excipient.
The present invention is suitable for water-soluble drinking, and effervescent tablet is when being added to the water, and the gas of effervesce produces and generates transparent solution, tobacco extract and nicotine along with the disintegration rapid solution of disintegrant in water.Effervescent tablet of the present invention can rapid recovery smoker ban on opium-smoking and the opium trade environment under craving for tobacco, the hobby of tobacco consumer can be met to a certain extent, also reduce some carcinogens of discharging in burning cigarette process to the injury of human body, can also result of combustion of tobacco be reduced and the second-hand-cigarette brought to the harm of unnecessary crowd, there is features such as conveniently drinking, be easy to carry, be novel, and solve the volatile characteristic of nicotine, the portion of energy of needed by human body can also be supplemented.Effervescent tablet uses not by the impact of water temperature, without residue.Effervescent tablet of the present invention is the once change that smoker alleviates craving for tobacco, and market prospects are good.
Detailed description of the invention
The effervescent tablet that the present invention contains nicotine material is in effervescent tablet, be added with nicotine extract bag and thing.Concrete, effervescent tablet of the present invention by weight, at least includes bag and thing 8% ~ 10%, acid ingredient material 15% ~ 30%, alkaline components material 20% ~ 40%, appropriate adhesive, the appropriate lubricant of nicotine extract.Nicotine extract refers to the mixture of tobacco extract or nicotine active component composition or tobacco extract and nicotine active component composition.Tobacco extract can directly be purchased from market or prepare voluntarily according to prior art.Nicotine active component composition directly can be purchased from market, as: tobacco extract, nicotine sterling.The inclusion compound of nicotine extract to be weight ratio be 0.5% ~ 5% nicotine extract and weight ratio be 95% ~ 99.5% cyclodextrin or the resin material such as polacrilin, polacrilin potassium carry out inclusion after the mixture of powders that formed.
According to demand, can also add appropriate excipient in effervescent tablet, as one or more in sweetener, aromatic, colouring agent, buffer, diluent, solubilizer, wetting agent, these excipient all can be bought from Market Selection.Described alkaline components is normally used is carbonate, as the mixture of one or more in sodium acid carbonate, sodium carbonate, potash.The selection of carbonate is extremely important, except the effervesce providing effervescent tablet in disintegrating procedue, can also affect the stability of effervescent tablet.Wherein sodium acid carbonate is because soluble in water and cost is lower, and comparatively sodium carbonate is stablized, and the most often uses.As acid ingredient, one or more the mixture that comparatively conventional is in the citric acid, tartaric acid, fumaric acid, malic acid etc. of hydration and anhydrous form.In manufacturing process, fast with citric acid moisture absorption, replace citric acid with tartaric acid, moisture absorption can reduce, but mouthfeel is good not as citric acid, regulates mouthfeel usually through adding the flavourings such as honey element.Bronsted lowry acids and bases bronsted lowry is neccessary composition, can cause the disintegration of effervesce and tablet when effervescent tablet contacts with water, targeted activity composition and nicotine also can thereupon rapid solution in water.Adhesive can be good at pressed powder inclusion together, to facilitate granulation, usually selects absolute ethyl alcohol or ethanolic solution (PVP K30).Lubricant is microcrystalline cellulose or starch.Lubricant is selected from the compound being dissolved in water completely, to form the clear and bright aqueous solution, often selects one or more in Macrogol 6000, Macrogol 4000, Sodium Benzoate, alanine, glycine, sodium acetate dolomol.
Embodiment 1
The effervescent tablet that the present embodiment contains nicotine material is made up of the raw material of following mass parts: take the inclusion compound containing nicotine extract of effervescent tablet gross weight 10% and be equally divided into two parts, malic acid, the potash of 30%, the appropriate starch of 20%.Inclusion compound containing nicotine extract to be weight ratio be 0.5% nicotine sterling and weight ratio be the inclusion compound of the cyclodextrin encapsulated formation of 99.5%.Get a inclusion compound containing nicotine extract to mix with malic acid and starch, use absolute ethyl alcohol wet granulation, drying obtains acidic mixed composition granule; Get the inclusion compound of another part containing nicotine extract to mix with potash and starch, use absolute ethyl alcohol wet granulation, drying obtains alkaline mixt particle; Compression molding after finally being mixed with alkaline mixt uniform particles by acidic mixed composition granule, namely obtains the effervescent tablet containing nicotine.
Embodiment 2
The effervescent tablet that the present embodiment contains nicotine material is made up of the raw material of following mass parts: take the inclusion compound containing nicotine extract of effervescent tablet gross weight 8%, 15% citric acid, 30% potash, the sodium acid carbonate of 20%, appropriate dolomol, appropriate microcrystalline cellulose, appropriate excipient (lactose and sucrose) and flavouring (honey element).Inclusion compound containing nicotine extract to be weight ratio be 3% tobacco extract and weight ratio be 97% the inclusion compound that formed of polacrilin inclusion.Get 1/3rd inclusion compounds containing nicotine extract to mix with citric acid, colouring agent, lactose and sucrose, microcrystalline cellulose, honey element, with absolute ethyl alcohol or PVPK30 ethanolic solution wet granulation, drying obtains acidic mixed composition granule; Under remainder 2/3rds inclusion compounds containing nicotine extract mix with sodium acid carbonate and dolomol, and with absolute ethyl alcohol or PVPK30 ethanolic solution wet granulation, drying obtains alkaline mixt particle; Compression molding after finally being mixed with alkaline mixt uniform particles by acidic mixed composition granule, namely obtains the effervescent tablet containing nicotine.
Embodiment 3
The effervescent tablet that the present embodiment contains nicotine material is made up of the raw material of following mass parts: take the inclusion compound containing nicotine extract of effervescent tablet gross weight 10%, 30% tartaric acid, the sodium acid carbonate of 40%, appropriate Macrogol 6000, Macrogol 4000, appropriate excipient (lactose and sucrose) and flavouring (acesulfame potassium).Inclusion compound containing nicotine extract to be weight ratio be 5% leaf tobacco extract and weight ratio be the inclusion compound that the cyclodextrin of 90% and the polacrilin potassium inclusion of 5% are formed.Get the only about half of inclusion compound containing nicotine extract to mix with tartaric acid, part Macrogol 6000, part Macrogol 4000, with PVPK30 solution wet granulation, drying obtains acidic mixed composition granule; The inclusion compound containing nicotine extract under remainder mixes with sodium acid carbonate, remaining Macrogol 6000 and Macrogol 4000, lactose, sucrose, acesulfame potassium, and with PVPK30 solution wet granulation, drying obtains alkaline mixt particle; Compression molding after finally being mixed with alkaline mixt uniform particles by acidic mixed composition granule, namely obtains the effervescent tablet containing nicotine.
Embodiment 4
The effervescent tablet that the present embodiment contains nicotine material is made up of the raw material of following mass parts: take effervescent tablet gross weight 9% the inclusion compound containing nicotine extract and be equally divided into two parts, the fumaric acid of 20%, 25% potash, the sodium carbonate of 15%, appropriate microcrystalline cellulose, appropriate excipient (fruity flavor) and flavouring (acesulfame potassium), appropriate amino acid and sodium chloride.Inclusion compound containing nicotine extract to be weight ratio the be nicotine sterling of 0.5% and the tobacco extract of 1% and weight ratio are the inclusion compound of the cyclodextrin encapsulated formation of 98.5%.Get the inclusion compound that half contains nicotine extract to mix with fumaric acid, fruity flavor, acesulfame potassium, amino acid, use absolute ethyl alcohol wet granulation, drying obtains acidic mixed composition granule; Get second half inclusion compound containing nicotine extract to mix with potash and sodium carbonate, microcrystalline cellulose, sodium chloride, use absolute ethyl alcohol wet granulation, drying obtains alkaline mixt particle; Compression molding after finally being mixed with alkaline mixt uniform particles by acidic mixed composition granule, namely obtains the effervescent tablet containing nicotine.In the present embodiment, amino acid adds as nutriment, the effect that sodium chloride can play and regulate mouthfeel, reduction nicotine stimulates.
Embodiment 5
The effervescent tablet that the present embodiment contains nicotine material is made up of the raw material of following mass parts: take the inclusion compound containing nicotine extract of effervescent tablet gross weight 10%, 15% tartaric acid, 10% malic acid, the sodium carbonate of 30%, appropriate Sodium Benzoate, alanine, glycine, sodium acetate, appropriate buffer, appropriate diluent or solubilizer or wetting agent.Inclusion compound containing nicotine extract to be weight ratio be 4% cabo extractive and weight ratio be 96% the inclusion compound that formed of polacrilin potassium inclusion.Get the only about half of inclusion compound containing nicotine extract to mix with tartaric acid, malic acid, Sodium Benzoate, alanine, buffer, with PVPK30 solution wet granulation, drying obtains acidic mixed composition granule; The inclusion compound containing nicotine extract under remainder mixes with glycine, sodium acetate, diluent or solubilizer or wetting agent with sodium acid carbonate, and with PVPK30 solution wet granulation, drying obtains alkaline mixt particle; Compression molding after finally being mixed with alkaline mixt uniform particles by acidic mixed composition granule, namely obtains the effervescent tablet containing nicotine.
Claims (10)
1. containing the effervescent tablet of nicotine material, it is characterized in that, it contains the inclusion compound of active component nicotine extract, effervescent mixture and auxiliary material, and described nicotine extract refers to tobacco extract or/and nicotine active component composition; Described effervescent mixture refers to the mixture of acid ingredient material and alkaline components material; Described auxiliary material includes but not limited to adhesive, lubricant.
2. a kind of effervescent tablet containing nicotine material according to claim 1, is characterized in that, the inclusion compound of described nicotine extract to be weight ratio be 0.5% ~ 5% nicotine extract and the inclusion compound that formed of cyclodextrin or resin material inclusion.
3. a kind of effervescent tablet containing nicotine material according to claim 1, it is characterized in that, described effervescent tablet by weight, at least includes bag and thing 8% ~ 10%, acid ingredient material 15% ~ 30%, alkaline components material 20% ~ 40%, appropriate adhesive, the appropriate lubricant of nicotine extract.
4. a kind of effervescent tablet containing nicotine material according to claim 3, is characterized in that, in effervescent tablet, be also added with appropriate excipient; Described excipient is one or more in sweetener, aromatic, colouring agent, buffer, diluent, solubilizer, wetting agent.
5. a kind of effervescent tablet containing nicotine material according to claim 1, it is characterized in that, described alkaline components is one or more the mixture in sodium acid carbonate, sodium carbonate, potash.
6. a kind of effervescent tablet containing nicotine material according to claim 1, it is characterized in that, described acid ingredient is one or more the mixture in citric acid, tartaric acid, fumaric acid, malic acid.
7. a kind of effervescent tablet containing nicotine material according to claim 1, it is characterized in that, described adhesive is absolute ethyl alcohol or ethanolic solution.
8. a kind of effervescent tablet containing nicotine material according to claim 1, it is characterized in that, described lubricant is one or more in microcrystalline cellulose, starch, Macrogol 6000, Macrogol 4000, Sodium Benzoate, alanine, glycine, sodium acetate, dolomol.
9. the preparation method of a kind of effervescent tablet containing nicotine material as described in any one of claim 1-8, it is characterized in that, the inclusion compound of tobacco extract and auxiliary material are mixed and made into softwood with acid ingredient material and alkaline components material respectively, granulation respectively, drying, obtain acidic mixed composition granule and mix ingredients particle, then compression molding after being divided by acidic mixture particle to mix with alkaline mixt uniform particles.
10. the preparation method of a kind of effervescent tablet containing nicotine material according to claim 9; it is characterized in that; in preparation acidic mixed composition granule, alkaline mixt particle and acidic mixed composition granule and alkaline mixt particle mixed process, all excipient can be added.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510418426.3A CN104957777A (en) | 2015-07-16 | 2015-07-16 | Effervescent tablet containing nicotine matter and preparation method of effervescent tablet |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510418426.3A CN104957777A (en) | 2015-07-16 | 2015-07-16 | Effervescent tablet containing nicotine matter and preparation method of effervescent tablet |
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| CN104957777A true CN104957777A (en) | 2015-10-07 |
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| CN201510418426.3A Pending CN104957777A (en) | 2015-07-16 | 2015-07-16 | Effervescent tablet containing nicotine matter and preparation method of effervescent tablet |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105581378A (en) * | 2016-03-17 | 2016-05-18 | 云南中烟工业有限责任公司 | Ultrasonic atomization electronic cigarette smoke transmission system capable of automatically generating gas |
| CN106847298A (en) * | 2017-02-24 | 2017-06-13 | 海信集团有限公司 | A kind of sound pick-up method and device based on diffused interactive voice |
| CN114568736A (en) * | 2020-11-30 | 2022-06-03 | 上海烟草集团有限责任公司 | Buccal cigarette and preparation method thereof |
| US11844374B2 (en) | 2017-10-12 | 2023-12-19 | Nicoventures Trading Limited | Aerosol provision systems |
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| CN101919825A (en) * | 2009-07-14 | 2010-12-22 | 无锡健而乐医药科技有限公司 | The buccal absorption solid effervescent mixture |
| CN103153099A (en) * | 2010-09-07 | 2013-06-12 | R.J.雷诺兹烟草公司 | Smokeless tobacco product comprising effervescent composition |
| CN104039178A (en) * | 2011-12-14 | 2014-09-10 | R.J.雷诺兹烟草公司 | Smokeless tobacco product comprising effervescent composition |
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2015
- 2015-07-16 CN CN201510418426.3A patent/CN104957777A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101919825A (en) * | 2009-07-14 | 2010-12-22 | 无锡健而乐医药科技有限公司 | The buccal absorption solid effervescent mixture |
| CN103153099A (en) * | 2010-09-07 | 2013-06-12 | R.J.雷诺兹烟草公司 | Smokeless tobacco product comprising effervescent composition |
| CN104039178A (en) * | 2011-12-14 | 2014-09-10 | R.J.雷诺兹烟草公司 | Smokeless tobacco product comprising effervescent composition |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105581378A (en) * | 2016-03-17 | 2016-05-18 | 云南中烟工业有限责任公司 | Ultrasonic atomization electronic cigarette smoke transmission system capable of automatically generating gas |
| CN105581378B (en) * | 2016-03-17 | 2018-05-18 | 云南中烟工业有限责任公司 | A kind of self generating gas ultrasonic atomizatio electronics flue gas Transmission system |
| CN106847298A (en) * | 2017-02-24 | 2017-06-13 | 海信集团有限公司 | A kind of sound pick-up method and device based on diffused interactive voice |
| CN106847298B (en) * | 2017-02-24 | 2020-07-21 | 海信集团有限公司 | Pickup method and device based on diffuse type voice interaction |
| US11844374B2 (en) | 2017-10-12 | 2023-12-19 | Nicoventures Trading Limited | Aerosol provision systems |
| CN114568736A (en) * | 2020-11-30 | 2022-06-03 | 上海烟草集团有限责任公司 | Buccal cigarette and preparation method thereof |
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Application publication date: 20151007 |