CN104888012A - Traditional Chinese medicine tincture for treating psoriasis and preparation method of traditional Chinese medicine tincture - Google Patents

Abstract

The invention provides a traditional Chinese medicine tincture for treating psoriasis and a preparation method of the traditional Chinese medicine tincture and relates to the technical field of treatment of psoriasis. The traditional Chinese medicine tincture takes effect quickly and is high in cure rate. The prepared tincture comprises effective ingredients of raw materials in parts by mass as follows: 20-35 parts of rhubarb, 9-21 parts of oriental stephania roots, 14-28 parts of Hemigraphis procumbens (Lour.) Merr., 10-25 parts of indigowoad leaves, 6-18 parts of Chinese hibisci rosae-sinensis flowers, 17-29 parts of lotus seeds, 8-26 parts of Avena fatua L., 10-21 parts of roots of rice paper plant, 7-22 parts of millet, 12-27 parts of roots of cherry elaeagnus, 10-24 parts of peach leaves, 15-35 parts of chrysanthemum, 5-25 parts of cicada slough, 10-30 parts of belvedere fruit, 5-25 parts of platycodon roots, 8-26 parts of dandelion, 17-31 parts of plantain herb, 7-22 parts of drug sweetflag rhizomes, 10-25 parts of parslane herb and 12-27 parts of liquorice. The traditional Chinese medicine tincture can promote cure of psoriasis, and the total effective cure rate is up to 98% and higher.

Description

One treats psoriasic Traditional Chinese medicine tincture preparation and preparation method thereof

Technical field

The present invention relates to treatment psoriasis technical field, specifically one treats psoriasic Traditional Chinese medicine tincture preparation and preparation method thereof.

Background technology

Psoriasis is as dermatosis, and morbidity does not have regularity, and be easy to recurrence, some patient loses confidence because of the recurrent exerbation of the state of an illness to treatment.Psoriasis is often divided into three types by the traditional Chinese medical science: rheumatism pattern of fever, often show as damp and hot heap soil or fertilizer over and around the roots and contain, venation is obstructed; Blood-heat type often shows as scorchingly hot penting up, strongly fragrant in blood system; Septic often shows as retention of damp-heat in the interior, scorchingly hot flourishing.Rheumatism pattern of fever common manifestation symptom is general of erythema, desquamation, fold place have humidity, erosion, joint congestion and swelling pain, body abdominal distention, indigestion and loss of appetite, yellow and greasy fur, red tongue, slippery and rapid pulse; Blood-heat type is more common in the phase of carrying out, and reveal any symptoms is that erythra occurs and develops rapidly, local flushing, newborn erythra constantly occurs, squama can not cover erythema, conscious pruritus, and has the diseases such as susceptible to lose temper due to restlessness, dry mouth and tougue, laryngopharynx swelling and pain, constipation, oliguria with reddish urine, red tongue with yellow fur; Septicopyemia type type can be periodic flare, and reveal any symptoms often occurs together heat, vexed xerostomia, constipation, oliguria with reddish urine, red tongue or in furrowed tongue, slippery and rapid pulse.Dialectical: retention of damp-heat in the interior, scorchingly hot flourishing.The psoriasic method of western medical treatment often adopts steroid hormone method, suppresses DNA class medicine, phototherapy, antitumor drug, can treat general hair style or the obstinate type in local psoriasis skin lesion, but these medicines increase in the side effect for the treatment of psoriasis disease life-time service, but drug withdrawal is easily recurred, cure low and cannot effect a radical cure.

Summary of the invention

The object of the invention is to overcome the above problems, and provide and treat psoriasic Traditional Chinese medicine tincture preparation and preparation method thereof in the one of responding well to treatment to skin soon, cure rate is high.

The technical solution used in the present invention is: one treats psoriasic Traditional Chinese medicine tincture preparation, the crude drug effective ingredient mass fraction making tincture comprises: Radix Et Rhizoma Rhei 20 ~ 35 parts, Radix Stephaniae Cepharanthae 9 ~ 21 parts, attached column spends 14 ~ 28 parts, Folium Isatidis 10 ~ 25 parts, Flos Hibisci Rosae-Sinensis 6 ~ 18 parts, 17 ~ 29 parts, Semen Nelumbinis, Herba avenae fatuae 8 ~ 26 parts, Radix tetrapanacis Koch 10 ~ 21 parts, Semen setariae 7 ~ 22 parts, Radix Elaeagni Multiflorae 12 ~ 27 parts, Folium Persicae 10 ~ 24 parts, Flos Chrysanthemi 15 ~ 35 parts, Periostracum Cicadae 5 ~ 25 parts, the Fructus Kochiae 10 ~ 30 parts, Radix Platycodonis 5 ~ 25 parts, Herba Taraxaci 8 ~ 26 parts, Herba Plantaginis 17 ~ 31 parts, Rhizoma Acori Graminei 7 ~ 22 parts, Herba Portulacae 10 ~ 25 parts, 12 ~ 27 parts, Radix Glycyrrhizae.

Further, one treats psoriasic Traditional Chinese medicine tincture preparation, the crude drug effective ingredient mass fraction making tincture comprises: Radix Et Rhizoma Rhei 25 ~ 30 parts, Radix Stephaniae Cepharanthae 13 ~ 18 parts, attached column spends 17 ~ 25 parts, Folium Isatidis 15 ~ 20 parts, Flos Hibisci Rosae-Sinensis 11 ~ 14 parts, 20 ~ 25 parts, Semen Nelumbinis, Herba avenae fatuae 13 ~ 21 parts, Radix tetrapanacis Koch 14 ~ 17 parts, Semen setariae 12 ~ 17 parts, Radix Elaeagni Multiflorae 17 ~ 22 parts, Folium Persicae 15 ~ 19 parts, Flos Chrysanthemi 19 ~ 26 parts, Periostracum Cicadae 10 ~ 20 parts, the Fructus Kochiae 15 ~ 25 parts, Radix Platycodonis 10 ~ 20 parts, Herba Taraxaci 13 ~ 21 parts, Herba Plantaginis 21 ~ 26 parts, Rhizoma Acori Graminei 12 ~ 17 parts, Herba Portulacae 15 ~ 20 parts, 17 ~ 22 parts, Radix Glycyrrhizae.

Further; one treats psoriasic Traditional Chinese medicine tincture preparation, and the crude drug effective ingredient mass fraction making tincture comprises: Radix Et Rhizoma Rhei 28 parts, Radix Stephaniae Cepharanthae 15 parts, attached column spend 20 parts, Folium Isatidis 17 parts, Flos Hibisci Rosae-Sinensis 13 parts, 22 parts, Semen Nelumbinis, Herba avenae fatuae 18 parts, Radix tetrapanacis Koch 16 parts, Semen setariae 14 parts, Radix Elaeagni Multiflorae 20 parts, Folium Persicae 17 parts, Flos Chrysanthemi 20 parts, Periostracum Cicadae 15 parts, the Fructus Kochiae 20 parts, Radix Platycodonis 15 parts, Herba Taraxaci 16 parts, Herba Plantaginis 24 parts, Rhizoma Acori Graminei 14 parts, Herba Portulacae 17 parts, 20 parts, Radix Glycyrrhizae.

Further, a kind of preparation method for the treatment of psoriasic Traditional Chinese medicine tincture preparation, preparation method is as follows:

(1) soak: take each raw material by above-mentioned mass fraction, gross weight is designated as 1 part, adds 6 parts of purified water, 40-50 DEG C is soaked 1h, obtains soak;

(2) decoct: after the soak that step (1) obtains being heated to boiling, boil 2h, be separated and take out fried liquid, continue the purified water adding 4 parts in medical material, continue to boil 1.5h after being heated to boiling, merge twice fried liquid and be extracting solution;

(3) supercritical extraction: the extracting solution that step (2) obtains is positioned in the extraction kettle in supercritical extraction instrument, carbon dioxide is utilized to extract as medium, extraction kettle pressure is 40Mpa, extraction temperature is 45 DEG C, separator pressure 12Mpa, separator temperature is 70 DEG C, extracts 2 hours, is extracted liquid;

(4) concentrated: extract step (3) obtained concentrates at outer circulation concentrator, and concentrated condition is: pressure 0.03Mpa, temperature 70 C, is concentrated into the extractum that relative density is 1.13 ~ 1.14;

(5) by extractum obtained for step (4) and the starch or the Icing Sugar Homogeneous phase mixing that account for extractum gross mass 10%, cross 16 mesh sieves and make wet grain, grain will be wet in 50 DEG C of dryings, with 16 mesh sieve granulate, add the magnesium stearate accounting for medicine gross mass 1%, mixing, is pressed into tablet with tablet machine, every sheet 0.8 gram.

Instructions of taking: every day three times 10 days is a course for the treatment of.

Medical material effect of the present invention is resolved as follows:

Radix Et Rhizoma Rhei bitter in the mouth, cold in nature, effect purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation, for excess-heat constipation, stagnant stomachache, dysentery is not well, jaundice due to damp-heat, and heat in blood tells nosebleed, conjunctival congestion, pharyngeal swelling, abdominalgia with intestinal abscess, carbuncle furuncle, blood stasis amenorrhea, traumatic injury, burn due to hot liquid or fire; Upper gastrointestinal hemorrhage.Radix Stephaniae Cepharanthae bitter in the mouth is pungent, cool in nature, has effect of heat-clearing and toxic substances removing, wind-expelling pain-stopping, cooling blood for hemostasis, main laryngopharynx swelling and pain; Pyretic toxicity carbuncle; Rheumatic arthralgia; Stomachache; Dysentery; Spit blood; Epistaxis; Traumatic hemorrhage.Attached column flower mildly bitter flavor; Pungent; Cool in nature, have that heat-clearing and toxic substances removing, dampness removing are antipruritic, effect of reducing swelling and alleviating pain.Main dysentery, skin infection, eczema, skin pruritus, caterpillar are stabbed, traumatic injury.Folium Isatidis bitter in the mouth, cold in nature, there is heat-clearing and toxic substances removing, effect of blood cooling and ecchymoses removing, for the high hot excessive thirst of calentura; Coma; Macule; Spit blood; Epistaxis; Jaundice; Dysentery; Erysipelas; Sore throat; Aphtha; Mumps.Flos Hibisci Rosae-Sinensis sweet in the mouth, cold in nature, function is lung heat clearing, reduces phlegm, removing heat from blood, and removing toxic substances, mainly controls phlegm-fire cough, epistaxis, dysentery, reddish and whitish turbid urine, carbuncle, skin infection.Semen Nelumbinis sweet in the mouth, puckery, property is put down, and has spleen reinforcing antidiarrheal, leukorrhagia stopping, kidney tonifying arresting seminal emission, effect of tranquilizing by nourishing the heart, is mainly used in treating diarrhea due to hypofunction of the spleen, leukorrhagia, seminal emission, palpitation and insomnia.Herba avenae fatuae sweet in the mouth, property is put down, astringing to arrest bleeding, strengthening superficial resistance to stop perspiration, and for spitting blood, metrorrhagia, leucorrhea, has blood in stool, spontaneous perspiration, night sweat.Radix tetrapanacis Koch taste is scorching; Micro-hardship; Cold nature, main main edema; Stranguria; Food stagnation drink is swollen; Mass in the abdomen; Rheumatic arthralgia; Menoxenia; Agalactia.Semen setariae is cool in nature, sweet-salty, takes a tonic or nourishing food to build up one's health kidney qi, removes spleen pathogenic heat in the stomach, QI invigorating.Old person's bitter in the mouth.Gastric heat can be controlled, quench one's thirst, diuresis, stopping leak dysentery, separate borax and Semen Tritici aestivi poison.Radix Elaeagni Multiflorae, puckery, micro-sweet, property is put down, and has promoting flow of QI and blood, antidiarrheal, the function of sore, main traumatic injury, weak strain, dysentery, hepatitis, malignant boil mange.Folium Persicae bitter in the mouth, property are flat, have wind-damp dispelling, heat clearing away, effect of parasite killing, control wind syndrome of head, headache, migratory arthralgia, malaria, eczema, skin infection, tinea skin ulcer.Flos Chrysanthemi bitter in the mouth, cool in nature, have dispelling wind, heat clearing away, improving eyesight, effect of removing toxic substances, controls headache, dizzy, conjunctival congestion, irritable feverish sensation of chest and heart, furuncle, toxic swelling.Periostracum Cicadae sweet in the mouth, salty, cool in nature, dispelling wind and heat pathogens, relieving sore throat to recover voice, rash, improving acuity of vision and removing nebula, endogenous wind stopping relieving convulsion.Fructus Kochiae acrid in the mouth, hardship, cold in nature, there is clearing away heat-damp and promoting diuresis, effect of dispelling wind for relieving itching, for difficulty and pain in micturition, pudendal pruritus leukorrhagia, rubella, eczema, skin pruritus.Radix Platycodonis lung qi dispersing, sore-throat relieving, eliminates the phlegm, evacuation of pus.For cough with copious phlegm, uncomfortable in chest not smooth, pharyngalgia, hoarseness, lung abscess vomiting pus, skin infection difficulty in discharging of pus.Herba Taraxaci bitter but sweet flavor, cold in nature, have heat-clearing and toxic substances removing, effect of diuresis eliminating stagnation, controls acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, urinary tract infection.Herba Plantaginis sweet in the mouth, cold in nature, there is heat clearing away, diuresis, eliminate the phlegm, removing heat from blood, effect of removing toxic substances, for edema oliguria, the puckery pain of pyretic stranguria, heat-damp in summer dysentery, phlegm-heat cough, hematemesis and epistaxis, carbuncle sore tumefacting virus.Rhizoma Acori Graminei is bitter, pungent, temperature.Have and reduce phlegm, have one's ideas straightened out, spleen invigorating, effect of dampness removing, for epilepsy, palpitate with fear forgetful, obnubilation, humidity hysteresis painful abdominal mass is swollen, dysentery, rheumatalgia, carbuncle scabies.Herba Portulacae sour in the mouth, cold in nature, have heat-clearing and toxic substances removing, cooling blood for hemostasis, effect of dysentery relieving, cures mainly toxic-heat and blood stasis, carbuncle furuncle, eczema, erysipelas, and snake bite and insect sting, has blood in stool, hemorrhoidal bleeding, metrostaxis.Radix Glycyrrhizae sweet in the mouth, property are flat, and it contains number of chemical composition, and effect is replenishing QI to invigorate the spleen, expelling phlegm for arresting cough, heat-clearing and toxic substances removing, relieving spasm to stop pain.

The present invention has following beneficial effect:

(1) Radix Et Rhizoma Rhei purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation is monarch drug, Radix Stephaniae Cepharanthae heat-clearing and toxic substances removing, wind-expelling pain-stopping, cooling blood for hemostasis, attached column flower heat-clearing and toxic substances removing, dampness removing are antipruritic, reducing swelling and alleviating pain, Folium Isatidis heat-clearing and toxic substances removing, blood cooling and ecchymoses removing, Flos Hibisci Rosae-Sinensis lung heat clearing, reduce phlegm, removing heat from blood, removing toxic substances, Radix Stephaniae Cepharanthae, attached column flower, Folium Isatidis, Flos Hibisci Rosae-Sinensis are that ministerial drug heat-clearing and toxic substances removing assists monarch drug clearing away heat and cooling blood, purify the blood dry; Semen Nelumbinis spleen reinforcing antidiarrheal, leukorrhagia stopping, kidney tonifying arresting seminal emission, tranquilizing by nourishing the heart, Herba avenae fatuae astringing to arrest bleeding, strengthening superficial resistance to stop perspiration, Radix tetrapanacis Koch edema stranguria, kidney qi taken a tonic or nourishing food to build up one's health by Semen setariae, removes spleen pathogenic heat in the stomach, QI invigorating, Radix Elaeagni Multiflorae promoting flow of QI and blood, antidiarrheal, sore, Semen Nelumbinis, Herba avenae fatuae, Radix tetrapanacis Koch, Semen setariae, Radix Elaeagni Multiflorae are adjuvant drug, can effectively lose by tonify deficiency, kidney tonifying arresting seminal emission.Folium Persicae wind-damp dispelling, heat clearing away, Flos Chrysanthemi dispelling wind, heat clearing away, improving eyesight, removing toxic substances, Periostracum Cicadae dispelling wind and heat pathogens, relieving sore throat to recover voice, rash, improving acuity of vision and removing nebula, endogenous wind stopping relieving convulsion, Fructus Kochiae clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching, Radix Platycodonis lung qi dispersing, sore-throat relieving, eliminate the phlegm, evacuation of pus, Herba Taraxaci bitter in the mouth heat-clearing and toxic substances removing, diuresis eliminating stagnation, Herba Plantaginis heat clearing away, diuresis, eliminate the phlegm, removing heat from blood, removing toxic substances, Rhizoma Acori Graminei is reduced phlegm, have one's ideas straightened out, spleen invigorating, dampness removing, Herba Portulacae heat-clearing and toxic substances removing, cooling blood for hemostasis, dysentery relieving, Radix Glycyrrhizae replenishing QI to invigorate the spleen, expelling phlegm for arresting cough, heat-clearing and toxic substances removing, relieving spasm to stop pain, Folium Persicae, Flos Chrysanthemi, Periostracum Cicadae, the Fructus Kochiae, Radix Platycodonis, Herba Taraxaci, Herba Plantaginis, Rhizoma Acori Graminei, Herba Portulacae, Radix Glycyrrhizae is for making medicine, replenishing QI to invigorate the spleen can be had, heat-clearing and toxic substances removing.

(2) first a period of time is soaked by purified water, medical material deliquescing, cell expansion before decoction, effective ingredient is easily fried, and medical material contains starch, protein, after soaking, prevent when decocting, the starch gelatinization on medical material surface, protein coagulating, the capillary channel on blocking medical material surface, makes the moisture when decocting enter not go, effective ingredient is not easily fried, affects curative effect of medication; Decoction can change the irritation effect of medicine, relatively mildly acts on skin, promotes the absorption of medicine; Supercritical extraction, immersion, concentration step retain the effective ingredient in Chinese medicine of the present invention to greatest extent, thus the quality improving tincture reaches refining object.

Detailed description of the invention

Below in conjunction with embodiment, the present invention is further elaborated.

Embodiment 1:

One treats psoriasic Traditional Chinese medicine tincture preparation, and the crude drug effective ingredient mass fraction making tincture comprises: Radix Et Rhizoma Rhei 20 parts, Radix Stephaniae Cepharanthae 9 parts, attached column spend 14 parts, Folium Isatidis 10 parts, Flos Hibisci Rosae-Sinensis 6 parts, 17 parts, Semen Nelumbinis, Herba avenae fatuae 8 parts, Radix tetrapanacis Koch 10 parts, Semen setariae 7 parts, Radix Elaeagni Multiflorae 12 parts, Folium Persicae 10 parts, Flos Chrysanthemi 15 parts, Periostracum Cicadae 5 parts, the Fructus Kochiae 10 parts, Radix Platycodonis 5 parts, Herba Taraxaci 8 parts, Herba Plantaginis 17 parts, Rhizoma Acori Graminei 7 parts, Herba Portulacae 10 parts, 12 parts, Radix Glycyrrhizae.

A kind of preparation method for the treatment of psoriasic Traditional Chinese medicine tincture preparation:

(1) soak: take each raw material by above-mentioned mass fraction, gross weight is designated as 1 part, adds 6 parts of purified water, 40 DEG C are soaked 1h, obtain soak;

(2) decoct: after the soak that step (1) obtains being heated to boiling, boil 2h, be separated and take out fried liquid, continue the purified water adding 4 parts in medical material, continue to boil 1.5h after being heated to boiling, merge twice fried liquid and be extracting solution;

(3) supercritical extraction: the extracting solution that step (2) obtains is positioned in the extraction kettle in supercritical extraction instrument, carbon dioxide is utilized to extract as medium, extraction kettle pressure is 40Mpa, extraction temperature is 45 DEG C, separator pressure 12Mpa, separator temperature is 70 DEG C, extracts 2 hours, is extracted liquid;

(4) concentrated: extract step (3) obtained concentrates at outer circulation concentrator, and concentrated condition is: pressure 0.03Mpa, temperature 70 C, is concentrated into the extractum that relative density is 1.13;

(5) add in the extractum obtained to step (4) mass fraction be 75% ethanol to the weight of feed liquid be 800 parts and carry out homogenizing, after high temperature sterilization, obtain the psoriasic tincture of described treatment.

Embodiment 2:

One treats psoriasic Traditional Chinese medicine tincture preparation, and the crude drug effective ingredient mass fraction making tincture comprises: Radix Et Rhizoma Rhei 35 parts, Radix Stephaniae Cepharanthae 21 parts, attached column spend 28 parts, Folium Isatidis 25 parts, Flos Hibisci Rosae-Sinensis 18 parts, 29 parts, Semen Nelumbinis, Herba avenae fatuae 26 parts, Radix tetrapanacis Koch 21 parts, Semen setariae 22 parts, Radix Elaeagni Multiflorae 27 parts, Folium Persicae 24 parts, Flos Chrysanthemi 35 parts, Periostracum Cicadae 25 parts, the Fructus Kochiae 30 parts, Radix Platycodonis 25 parts, Herba Taraxaci 26 parts, Herba Plantaginis 31 parts, Rhizoma Acori Graminei 22 parts, Herba Portulacae 25 parts, 27 parts, Radix Glycyrrhizae.

A kind of preparation method for the treatment of psoriasic Traditional Chinese medicine tincture preparation:

(1) soak: take each raw material by above-mentioned mass fraction, gross weight is designated as 1 part, adds 6 parts of purified water, 45 DEG C are soaked 1h, obtain soak;

(2) decoct: after the soak that step (1) obtains being heated to boiling, boil 2h, be separated and take out fried liquid, continue the purified water adding 4 parts in medical material, continue to boil 1.5h after being heated to boiling, merge twice fried liquid and be extracting solution;

(3) supercritical extraction: the extracting solution that step (2) obtains is positioned in the extraction kettle in supercritical extraction instrument, carbon dioxide is utilized to extract as medium, extraction kettle pressure is 40Mpa, extraction temperature is 45 DEG C, separator pressure 12Mpa, separator temperature is 70 DEG C, extracts 2 hours, is extracted liquid;

(4) concentrated: extract step (3) obtained concentrates at outer circulation concentrator, and concentrated condition is: pressure 0.03Mpa, temperature 70 C, is concentrated into the extractum that relative density is 1.13 ~ 1.14;

(5) add in the extractum obtained to step (4) mass fraction be 75% ethanol to the weight of feed liquid be 800 parts and carry out homogenizing, after high temperature sterilization, obtain the psoriasic tincture of described treatment.

Embodiment 3:

One treats psoriasic Traditional Chinese medicine tincture preparation, and the crude drug effective ingredient mass fraction making tincture comprises: Radix Et Rhizoma Rhei 25 parts, Radix Stephaniae Cepharanthae 13 parts, attached column spend 17 parts, Folium Isatidis 15 parts, Flos Hibisci Rosae-Sinensis 11 parts, 20 parts, Semen Nelumbinis, Herba avenae fatuae 13 parts, Radix tetrapanacis Koch 14 parts, Semen setariae 12 parts, Radix Elaeagni Multiflorae 17 parts, Folium Persicae 15 parts, Flos Chrysanthemi 19 parts, Periostracum Cicadae 10 parts, the Fructus Kochiae 15 parts, Radix Platycodonis 10 parts, Herba Taraxaci 13 parts, Herba Plantaginis 21 parts, Rhizoma Acori Graminei 12 parts, Herba Portulacae 15 parts, 17 parts, Radix Glycyrrhizae.

A kind of preparation method for the treatment of psoriasic Traditional Chinese medicine tincture preparation:

(1) soak: take each raw material by above-mentioned mass fraction, gross weight is designated as 1 part, adds 6 parts of purified water, 50 DEG C are soaked 1h, obtain soak;

(2) decoct: after the soak that step (1) obtains being heated to boiling, boil 2h, be separated and take out fried liquid, continue the purified water adding 4 parts in medical material, continue to boil 1.5h after being heated to boiling, merge twice fried liquid and be extracting solution;

(3) supercritical extraction: the extracting solution that step (2) obtains is positioned in the extraction kettle in supercritical extraction instrument, carbon dioxide is utilized to extract as medium, extraction kettle pressure is 40Mpa, extraction temperature is 45 DEG C, separator pressure 12Mpa, separator temperature is 70 DEG C, extracts 2 hours, is extracted liquid;

(4) concentrated: extract step (3) obtained concentrates at outer circulation concentrator, and concentrated condition is: pressure 0.03Mpa, temperature 70 C, is concentrated into the extractum that relative density is 1.13;

(5) add in the extractum obtained to step (4) mass fraction be 75% ethanol to the weight of feed liquid be 800 parts and carry out homogenizing, after high temperature sterilization, obtain the psoriasic tincture of described treatment.

Embodiment 4:

One treats psoriasic Traditional Chinese medicine tincture preparation, and the crude drug effective ingredient mass fraction making tincture comprises: Radix Et Rhizoma Rhei 30 parts, Radix Stephaniae Cepharanthae 18 parts, attached column spend 25 parts, Folium Isatidis 20 parts, Flos Hibisci Rosae-Sinensis 14 parts, 25 parts, Semen Nelumbinis, Herba avenae fatuae 21 parts, Radix tetrapanacis Koch 17 parts, Semen setariae 17 parts, Radix Elaeagni Multiflorae 22 parts, Folium Persicae 19 parts, Flos Chrysanthemi 26 parts, Periostracum Cicadae 20 parts, the Fructus Kochiae 25 parts, Radix Platycodonis 20 parts, Herba Taraxaci 21 parts, Herba Plantaginis 26 parts, Rhizoma Acori Graminei 17 parts, Herba Portulacae 20 parts, 22 parts, Radix Glycyrrhizae.

A kind of preparation method for the treatment of psoriasic Traditional Chinese medicine tincture preparation:

(1) soak: take each raw material by above-mentioned mass fraction, gross weight is designated as 1 part, adds 6 parts of purified water, 40 DEG C are soaked 1h, obtain soak;

(2) decoct: after the soak that step (1) obtains being heated to boiling, boil 2h, be separated and take out fried liquid, continue the purified water adding 4 parts in medical material, continue to boil 1.5h after being heated to boiling, merge twice fried liquid and be extracting solution;

(3) supercritical extraction: the extracting solution that step (2) obtains is positioned in the extraction kettle in supercritical extraction instrument, carbon dioxide is utilized to extract as medium, extraction kettle pressure is 40Mpa, extraction temperature is 45 DEG C, separator pressure 12Mpa, separator temperature is 70 DEG C, extracts 2 hours, is extracted liquid;

(4) concentrated: extract step (3) obtained concentrates at outer circulation concentrator, and concentrated condition is: pressure 0.03Mpa, temperature 70 C, is concentrated into the extractum that relative density is 1.14;

(5) add in the extractum obtained to step (4) mass fraction be 75% ethanol to the weight of feed liquid be 800 parts and carry out homogenizing, after high temperature sterilization, obtain the psoriasic tincture of described treatment.

Embodiment 5:

One treats psoriasic Traditional Chinese medicine tincture preparation, and the crude drug effective ingredient mass fraction making tincture comprises: Radix Et Rhizoma Rhei 28 parts, Radix Stephaniae Cepharanthae 15 parts, attached column spend 20 parts, Folium Isatidis 17 parts, Flos Hibisci Rosae-Sinensis 13 parts, 22 parts, Semen Nelumbinis, Herba avenae fatuae 18 parts, Radix tetrapanacis Koch 16 parts, Semen setariae 14 parts, Radix Elaeagni Multiflorae 20 parts, Folium Persicae 17 parts, Flos Chrysanthemi 20 parts, Periostracum Cicadae 15 parts, the Fructus Kochiae 20 parts, Radix Platycodonis 15 parts, Herba Taraxaci 16 parts, Herba Plantaginis 24 parts, Rhizoma Acori Graminei 14 parts, Herba Portulacae 17 parts, 20 parts, Radix Glycyrrhizae.

A kind of preparation method for the treatment of psoriasic Traditional Chinese medicine tincture preparation:

(1) soak: take each raw material by above-mentioned mass fraction, gross weight is designated as 1 part, adds 6 parts of purified water, 40 DEG C are soaked 1h, obtain soak;

(2) decoct: after the soak that step (1) obtains being heated to boiling, boil 2h, be separated and take out fried liquid, continue the purified water adding 4 parts in medical material, continue to boil 1.5h after being heated to boiling, merge twice fried liquid and be extracting solution;

(3) supercritical extraction: the extracting solution that step (2) obtains is positioned in the extraction kettle in supercritical extraction instrument, carbon dioxide is utilized to extract as medium, extraction kettle pressure is 40Mpa, extraction temperature is 45 DEG C, separator pressure 12Mpa, separator temperature is 70 DEG C, extracts 2 hours, is extracted liquid;

(4) concentrated: extract step (3) obtained concentrates at outer circulation concentrator, and concentrated condition is: pressure 0.03Mpa, temperature 70 C, is concentrated into the extractum that relative density is 1.14;

(5) add in the extractum obtained to step (4) mass fraction be 75% ethanol to the weight of feed liquid be 800 parts and carry out homogenizing, after high temperature sterilization, obtain the psoriasic tincture of described treatment.

Embodiment 6:

One treats psoriasic Traditional Chinese medicine tincture preparation, and the crude drug effective ingredient mass fraction making tincture comprises: Radix Et Rhizoma Rhei 25 parts, Radix Stephaniae Cepharanthae 16 parts, attached column spend 21 parts, Folium Isatidis 17 parts, Flos Hibisci Rosae-Sinensis 9 parts, 17 parts, Semen Nelumbinis, Herba avenae fatuae 8 parts, Radix tetrapanacis Koch 10 parts, Semen setariae 9 parts, Radix Elaeagni Multiflorae 16 parts, Folium Persicae 15 parts, Flos Chrysanthemi 20 parts, Periostracum Cicadae 10 parts, the Fructus Kochiae 15 parts, Radix Platycodonis 13 parts, Herba Taraxaci 16 parts, Herba Plantaginis 19 parts, Rhizoma Acori Graminei 15 parts, Herba Portulacae 15 parts, 18 parts, Radix Glycyrrhizae.

A kind of preparation method for the treatment of psoriasic Traditional Chinese medicine tincture preparation:

(1) soak: take each raw material by above-mentioned mass fraction, gross weight is designated as 1 part, adds 6 parts of purified water, 50 DEG C are soaked 1h, obtain soak;

(2) decoct: after the soak that step (1) obtains being heated to boiling, boil 2h, be separated and take out fried liquid, continue the purified water adding 4 parts in medical material, continue to boil 1.5h after being heated to boiling, merge twice fried liquid and be extracting solution;

(3) supercritical extraction: the extracting solution that step (2) obtains is positioned in the extraction kettle in supercritical extraction instrument, carbon dioxide is utilized to extract as medium, extraction kettle pressure is 40Mpa, extraction temperature is 45 DEG C, separator pressure 12Mpa, separator temperature is 70 DEG C, extracts 2 hours, is extracted liquid;

(4) concentrated: extract step (3) obtained concentrates at outer circulation concentrator, and concentrated condition is: pressure 0.03Mpa, temperature 70 C, is concentrated into the extractum that relative density is 1.14;

(5) add in the extractum obtained to step (4) mass fraction be 75% ethanol to the weight of feed liquid be 800 parts and carry out homogenizing, after high temperature sterilization, obtain the psoriasic tincture of described treatment.

Medicine of the present invention has carried out zoopery and clinical research, and its result is described below:

1, zoopery

Animal acute toxicity experiment, selects white mice 40, each 20 of male and female, sodium carboxymethyl cellulose solution with 1% makes the suspension of 50mg/ml, gavage body 0.56ml/10g, every day three times, observe animal activity after gavage 15 days, diet, feces, hair color and death condition, the results are shown in Table 1.

Animal acute toxicity experiment result:

Table 1

After experimental result gavage, the diet of animal, feces, none example of hair are abnormal, and after second, third gavage, much more slightly animal moves, and within about 10 minutes, the many emotionally conditions of animal disappear, and none example was dead on 15th.

Conclusion: maximum tolerated dose is ﹥ 7.35mg/kg is 147 times of the clinical maximal dose of people.

2, clinical data and case:

In order to show therapeutic effect of the present invention, system clinical observation treatment being carried out to 100 routine psoriatics, in the process of above-mentioned clinical observation, record being carried out to the medical history of above-mentioned patient, the state of an illness and curative effect.

Clinical therapeutic efficacy criterion is:

Cure: general of common symptom erythema, desquamation, fold place have humidity, erosion, susceptible to lose temper due to restlessness, dry mouth and tougue, laryngopharynx swelling and pain, constipation, oliguria with reddish urine, red tongue with yellow fur etc. all to disappear.

Take a turn for the better: general of common sympton erythema, desquamation, fold place have humidity, erosion, susceptible to lose temper due to restlessness, dry mouth and tougue, laryngopharynx swelling and pain, constipation, oliguria with reddish urine, red tongue with yellow fur etc. substantially to disappear.

Invalid: symptom is not improved.

Therapeutic effect: the present invention is through treating 100 routine psoriatics, and 98 examples take a turn for the better, and 2 examples are invalid, and total effective rate reaches 98%, and nobody occurs side effect.

Model case:

Case 1: patient Jiang so-and-so, man, 29 years old, general of patient's erythema, desquamation, fold place have humidity, erosion, susceptible to lose temper due to restlessness, dry mouth and tougue, laryngopharynx swelling and pain, constipation, oliguria with reddish urine, red tongue with yellow fur, after using 1 course for the treatment of of Traditional Chinese medicine tincture preparation of the present invention, symptom obviously alleviates, and continue 1 course for the treatment of of use, symptom all disappears.

Case 2: patient Lee, man, 48 years old, patient's erosion, susceptible to lose temper due to restlessness, dry mouth and tougue, laryngopharynx swelling and pain, constipation, oliguria with reddish urine, red tongue with yellow fur, after using 2 courses for the treatment of of Traditional Chinese medicine tincture preparation of the present invention, symptom is obviously improved, continue 2 courses for the treatment of of use, symptom all disappears.

Case 3: patient Jiang, female, 37 years old, general of patient's erythema, desquamation, fold place have humidity, erosion, susceptible to lose temper due to restlessness, dry mouth and tougue, laryngopharynx swelling and pain, constipation, oliguria with reddish urine, red tongue with yellow fur, after using 1 course for the treatment of of Traditional Chinese medicine tincture preparation of the present invention, symptom is clearly better, and after continuing to use 2 courses for the treatment of of Traditional Chinese medicine tincture preparation of the present invention, symptom all disappears.

The above is the preferred embodiment of the present invention; its object is to allow person skilled in the art understand content of the present invention and to be implemented; should be understood that; for those skilled in the art; under the premise without departing from the principles of the invention; can also make some improvements and modifications, these improvements and modifications are also considered as protection scope of the present invention.

Claims (4)

1. the psoriasic Traditional Chinese medicine tincture preparation for the treatment of, it is characterized in that, the effective ingredient mass fraction making tincture comprises: Radix Et Rhizoma Rhei 20 ~ 35 parts, Radix Stephaniae Cepharanthae 9 ~ 21 parts, attached column spends 14 ~ 28 parts, Folium Isatidis 10 ~ 25 parts, Hibiscus rosasinensis 6 ~ 18 parts, 17 ~ 29 parts, Semen Nelumbinis, Herba avenae fatuae 8 ~ 26 parts, Radix tetrapanacis Koch 10 ~ 21 parts, Semen setariae 7 ~ 22 parts, Radix Elaeagni Multiflorae 12 ~ 27 parts, Folium Persicae 10 ~ 24 parts, Flos Chrysanthemi 15 ~ 35 parts, Periostracum Cicadae 5 ~ 25 parts, the Fructus Kochiae 10 ~ 30 parts, Radix Platycodonis 5 ~ 25 parts, Herba Taraxaci 8 ~ 26 parts, Herba Plantaginis 17 ~ 31 parts, Rhizoma Acori Graminei 7 ~ 22 parts, Herba Portulacae 10 ~ 25 parts, 12 ~ 27 parts, Radix Glycyrrhizae.

2. one according to claim 1 treats psoriasic Traditional Chinese medicine tincture preparation, it is characterized in that, the effective ingredient mass fraction making tincture comprises: Radix Et Rhizoma Rhei 25 ~ 30 parts, Radix Stephaniae Cepharanthae 13 ~ 18 parts, attached column spends 17 ~ 25 parts, Folium Isatidis 15 ~ 20 parts, Hibiscus rosasinensis 11 ~ 14 parts, 20 ~ 25 parts, Semen Nelumbinis, Herba avenae fatuae 13 ~ 21 parts, Radix tetrapanacis Koch 14 ~ 17 parts, Semen setariae 12 ~ 17 parts, Radix Elaeagni Multiflorae 17 ~ 22 parts, Folium Persicae 15 ~ 19 parts, Flos Chrysanthemi 19 ~ 26 parts, Periostracum Cicadae 10 ~ 20 parts, the Fructus Kochiae 15 ~ 25 parts, Radix Platycodonis 10 ~ 20 parts, Herba Taraxaci 13 ~ 21 parts, Herba Plantaginis 21 ~ 26 parts, Rhizoma Acori Graminei 12 ~ 17 parts, Herba Portulacae 15 ~ 20 parts, 17 ~ 22 parts, Radix Glycyrrhizae.

3. one according to claim 1 treats psoriasic Traditional Chinese medicine tincture preparation, it is characterized in that, the effective ingredient mass fraction making tincture comprises: Radix Et Rhizoma Rhei 28 parts, Radix Stephaniae Cepharanthae 15 parts, attached column spend 20 parts, Folium Isatidis 17 parts, Hibiscus rosasinensis 13 parts, 22 parts, Semen Nelumbinis, Herba avenae fatuae 18 parts, Radix tetrapanacis Koch 16 parts, Semen setariae 14 parts, Radix Elaeagni Multiflorae 20 parts, Folium Persicae 17 parts, Flos Chrysanthemi 20 parts, Periostracum Cicadae 15 parts, the Fructus Kochiae 20 parts, Radix Platycodonis 15 parts, Herba Taraxaci 16 parts, Herba Plantaginis 24 parts, Rhizoma Acori Graminei 14 parts, Herba Portulacae 17 parts, 20 parts, Radix Glycyrrhizae.

4. treat a preparation method for psoriasic Traditional Chinese medicine tincture preparation, it is characterized in that, described preparation method concrete steps are as follows:

(1) soak: take each raw material by above-mentioned mass fraction, gross weight is designated as 1 part, adds 6 parts of purified water, 40-50 DEG C is soaked 1h, obtains soak;

(2) decoct: after the soak that step (1) obtains being heated to boiling, boil 2h, be separated and take out fried liquid, continue the purified water adding 4 parts in medical material, continue to boil 1.5h after being heated to boiling, merge twice fried liquid and be extracting solution;

(3) supercritical extraction: the extracting solution that step (2) obtains is positioned in the extraction kettle in supercritical extraction instrument, carbon dioxide is utilized to extract as medium, extraction kettle pressure is 40Mpa, extraction temperature is 45 DEG C, separator pressure 12Mpa, separator temperature is 70 DEG C, extracts 2 hours, is extracted liquid;

(4) concentrated: extract step (3) obtained concentrates at outer circulation concentrator, and concentrated condition is: pressure 0.03Mpa, temperature 70 C, is concentrated into the extractum that relative density is 1.13 ~ 1.14;

(5) add in the extractum obtained to step (4) mass fraction be 75% ethanol to the weight of feed liquid be 800 parts and carry out homogenizing, after high temperature sterilization, obtain the psoriasic tincture of described treatment.