CN104877578A - Composite medical pressure-sensitive adhesive and preparation method thereof - Google Patents
Composite medical pressure-sensitive adhesive and preparation method thereof Download PDFInfo
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- CN104877578A CN104877578A CN201510254532.2A CN201510254532A CN104877578A CN 104877578 A CN104877578 A CN 104877578A CN 201510254532 A CN201510254532 A CN 201510254532A CN 104877578 A CN104877578 A CN 104877578A
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Abstract
The invention provides a composite medical pressure-sensitive adhesive and a preparation method thereof. The composite medical pressure-sensitive adhesive comprises the following components: alpha-cyan ethyl acrylate, dibutyl phthalate, methacrylic acid, alginate, a cissampelos pareira extract and sweetgum resin, wherein the cissampelos pareira extract is extracted by adding water into a crude cissampelos pareira material to extract, concentrating, adding ethanol until the volume concentration of ethanol is 40-60%, filtering to obtain the supernate, and by recycling the ethanol until the volume concentration of the ethanol is less than 2-5%. The preparation method comprises the following steps: mixing and smelting alpha-cyan ethyl acrylate, dibutyl phthalate and methacrylic acid in an open mill, adding alginate, the cissampelos pareira extract and the sweetgum resin, continuously smelting until the components are uniformly dispersed, and vulcanizing by using a press vulcanizer, thereby obtaining the composite medical pressure-sensitive adhesive of requested thickness. Compared with the prior art, the composite medical pressure-sensitive adhesive has the advantages of good mechanical property, good biocompatibility, good injury heal promotion effect and the like.
Description
Technical field
The present invention relates to pressure sensitive adhesive field, be specifically related to a kind of composite medical pressure sensitive adhesive and preparation method thereof.
Background technology
Pressure sensitive adhesive is that a class only need apply slight pressure, can bond firmly tackiness agent with adherend.Due to pressure sensitive adhesive, there is certain tack and hold viscosity, and can Reusability in free of contamination situation, to by the feature such as maxxaedium is pollution-free after stripping, it is made to be widely used in electronic isolation, electronic component processing, enlarged color photograph, militaryly to have detectd the numerous areas such as malicious goods, automotive trim and medical treatment.Wherein, medical pressure sensitive adhesive is high especially to the requirement of performance, demand fulfillment: (1) can be bonding very well to various skin type (dry, moistening); (2) can remove and not stay any resistates or do not cause skin injury; Not skin irritation.
Because it can the medical pressure sensitive adhesive of noticing property repeatedly, be therefore widely used at medical field.But pressure sensitive adhesive also also exists poor air permeability, life-time service causes on skin and has ponding generation, makes the problems such as skin whiting.In addition, conventional pressure sensitive adhesive can produce stimulation or toxic side effect to skin, reduces its biocompatibility.
Summary of the invention
goal of the invention:the object of the present invention is to provide a kind of good mechanical property, good biocompatibility and wound healing composite medical pressure sensitive adhesive and preparation method thereof can be promoted.
technical scheme of the present invention:
A kind of composite medical pressure sensitive adhesive, by weight, comprises following component: ethyl α-cyanoacrylate 50 ~ 70 parts, dibutyl phthalate 10 ~ 25 parts, methacrylic acid 10 ~ 25 parts, alginates 5 ~ 15 parts, Common Cissampelos Herb extract 15 ~ 30 parts, liquidambar resinoid 1 ~ 10 part.
Preferably, by weight, following component is comprised: ethyl α-cyanoacrylate 58 ~ 64 parts, dibutyl phthalate 15 ~ 18 parts, methacrylic acid 18 ~ 22 parts, alginates 8 ~ 12 parts, Common Cissampelos Herb extract 23 ~ 25 parts, liquidambar resinoid 4 ~ 7 parts.
More preferably, by weight, following component is comprised: ethyl α-cyanoacrylate 60 parts, dibutyl phthalate 16 parts, methacrylic acid 20 parts, alginates 10 parts, Common Cissampelos Herb extract 24 parts, liquidambar resinoid 6 parts.
The extracting method of described Common Cissampelos Herb extract is as follows: after Common Cissampelos Herb crude drug extracting in water, concentrated, and adding ethanol to the volumetric concentration ratio of ethanol is 40 ~ 60%, filters, gets supernatant liquor, reclaim ethanol to ethanol contend concentration ratio lower than 2 ~ 5%
Described alginates is potassium alginate.
Described liquidambar resinoid is Resina Liquidambaris wet distillation extract.
A preparation method for composite medical pressure sensitive adhesive, comprises the steps:
(1) each component is taken by weight;
(2) by ethyl α-cyanoacrylate, dibutyl phthalate, methacrylic acid in mill mixing 25 ~ 40 minutes, again by alginates, Common Cissampelos Herb extract, liquidambar resinoid adds and continues mixing 25 ~ 30 minutes, make it dispersed, then be 40 ~ 50 DEG C with vulcanizing press at curing temperature, curing time is 2 ~ 4s, and sulfuration pressure is the composite pressure-sensitive adhesive being hot pressed into desired thickness under the condition of 4 ~ 6MPa.
beneficial effect:
The present invention, based on ethyl α-cyanoacrylate, adds dibutyl phthalate, methacrylic acid and alginates and carries out modification to its mechanical property, and be added with help wound healing traditional Chinese medicine ingredients to improve its medical value.Compared with prior art, there is good mechanical property, good biocompatibility and can promote the advantages such as wound healing.
Embodiment
Below the specific embodiment of the present invention is described in detail.
embodiment 1
A kind of composite medical pressure sensitive adhesive, by weight, comprises following component: ethyl α-cyanoacrylate 50 parts, dibutyl phthalate 10 parts, methacrylic acid 10 parts, potassium alginate 5 parts, Common Cissampelos Herb extract 15 parts, liquidambar resinoid 1 part; Wherein, the extracting method of Common Cissampelos Herb extract is as follows: after Common Cissampelos Herb crude drug extracting in water, concentrated, and adding ethanol to the volumetric concentration ratio of ethanol is 40 ~ 60%, filters, gets supernatant liquor, reclaim ethanol to ethanol contend concentration ratio lower than 2 ~ 5%.
The preparation method of composite medical pressure sensitive adhesive is as follows:
(1) each component is taken by weight;
(2) by ethyl α-cyanoacrylate, dibutyl phthalate, methacrylic acid in mill mixing 25 minutes, again by alginates, Common Cissampelos Herb extract, liquidambar resinoid adds and continues mixing 25 minutes, make it dispersed, then be 50 DEG C with vulcanizing press at curing temperature, curing time is 4s, and sulfuration pressure is the composite pressure-sensitive adhesive being hot pressed into desired thickness under the condition of 6MPa.
embodiment 2
A kind of composite medical pressure sensitive adhesive, by weight, comprises following component: ethyl α-cyanoacrylate 58 parts, dibutyl phthalate 15 parts, methacrylic acid 18 parts, potassium alginate 8 parts, Common Cissampelos Herb extract 23 parts, liquidambar resinoid 4 parts; Wherein, the extracting method of Common Cissampelos Herb extract is as follows: after Common Cissampelos Herb crude drug extracting in water, concentrated, and adding ethanol to the volumetric concentration ratio of ethanol is 40 ~ 60%, filters, gets supernatant liquor, reclaim ethanol to ethanol contend concentration ratio lower than 2 ~ 5%.
The preparation method of composite medical pressure sensitive adhesive is as follows:
(1) each component is taken by weight;
(2) by ethyl α-cyanoacrylate, dibutyl phthalate, methacrylic acid in mill mixing 28 minutes, again by alginates, Common Cissampelos Herb extract, liquidambar resinoid adds and continues mixing 26 minutes, make it dispersed, then be 47 DEG C with vulcanizing press at curing temperature, curing time is 4s, and sulfuration pressure is the composite pressure-sensitive adhesive being hot pressed into desired thickness under the condition of 6MPa.
embodiment 3
A kind of composite medical pressure sensitive adhesive, by weight, comprises following component: ethyl α-cyanoacrylate 60 parts, dibutyl phthalate 16 parts, methacrylic acid 20 parts, potassium alginate 10 parts, Common Cissampelos Herb extract 24 parts, liquidambar resinoid 6 parts; Wherein, the extracting method of Common Cissampelos Herb extract is as follows: after Common Cissampelos Herb crude drug extracting in water, concentrated, and adding ethanol to the volumetric concentration ratio of ethanol is 40 ~ 60%, filters, gets supernatant liquor, reclaim ethanol to ethanol contend concentration ratio lower than 2 ~ 5%.
The preparation method of composite medical pressure sensitive adhesive is as follows:
(1) each component is taken by weight;
(2) by ethyl α-cyanoacrylate, dibutyl phthalate, methacrylic acid in mill mixing 32 minutes, again by alginates, Common Cissampelos Herb extract, liquidambar resinoid adds and continues mixing 28 minutes, make it dispersed, then be 45 DEG C with vulcanizing press at curing temperature, curing time is 3s, and sulfuration pressure is the composite pressure-sensitive adhesive being hot pressed into desired thickness under the condition of 5MPa.
embodiment 4
A kind of composite medical pressure sensitive adhesive, by weight, comprises following component: ethyl α-cyanoacrylate 64 parts, dibutyl phthalate 18 parts, methacrylic acid 22 parts, potassium alginate 12 parts, Common Cissampelos Herb extract 25 parts, liquidambar resinoid 7 parts; Wherein, the extracting method of Common Cissampelos Herb extract is as follows: after Common Cissampelos Herb crude drug extracting in water, concentrated, and adding ethanol to the volumetric concentration ratio of ethanol is 40 ~ 60%, filters, gets supernatant liquor, reclaim ethanol to ethanol contend concentration ratio lower than 2 ~ 5%.
The preparation method of composite medical pressure sensitive adhesive is as follows:
(1) each component is taken by weight;
(2) by ethyl α-cyanoacrylate, dibutyl phthalate, methacrylic acid in mill mixing 36 minutes, again by alginates, Common Cissampelos Herb extract, liquidambar resinoid adds and continues mixing 28 minutes, make it dispersed, then be 42 DEG C with vulcanizing press at curing temperature, curing time is 2s, and sulfuration pressure is the composite pressure-sensitive adhesive being hot pressed into desired thickness under the condition of 4MPa.
embodiment 5
A kind of composite medical pressure sensitive adhesive, by weight, comprises following component: ethyl α-cyanoacrylate 70 parts, dibutyl phthalate 25 parts, methacrylic acid 25 parts, potassium alginate 15 parts, Common Cissampelos Herb extract 30 parts, liquidambar resinoid 10 parts; Wherein, the extracting method of Common Cissampelos Herb extract is as follows: after Common Cissampelos Herb crude drug extracting in water, concentrated, and adding ethanol to the volumetric concentration ratio of ethanol is 40 ~ 60%, filters, gets supernatant liquor, reclaim ethanol to ethanol contend concentration ratio lower than 2 ~ 5%.
The preparation method of composite medical pressure sensitive adhesive is as follows:
(1) each component is taken by weight;
(2) by ethyl α-cyanoacrylate, dibutyl phthalate, methacrylic acid in mill mixing 40 minutes, again by alginates, Common Cissampelos Herb extract, liquidambar resinoid adds and continues mixing 30 minutes, make it dispersed, then be 40 DEG C with vulcanizing press at curing temperature, curing time is 2s, and sulfuration pressure is the composite pressure-sensitive adhesive being hot pressed into desired thickness under the condition of 4MPa.
performance test 1:
By pressure sensitive adhesive melt coating obtained for embodiment 1 ~ 5, make pressure sensitive adhesive adhesive tape, carry out performance test, comprise tack, hold viscosity and 180 ° of stripping strengths, the results are shown in Table 1.
Tack is tested: by GB4852-84 standard, adopts CZY-G tack tester to measure;
Hold viscosity test: by GB4851-84 standard, adopt CZY-S to hold adhesiveness tester and measure;
180 ° of peel strength tests: by GB2792-81 standard, adopt LANGUANG electron detachment trier to measure;
Table 1
。
performance test 2:
Hemostasis convergence experiment: leg scratch patient 64 example, male 36 people, female 28 people, age 16 ~ 56(36 ± 16) year, hinder in first 1 week all without anticoagulation and hemostatic drug medication history.Two groups are divided at random: hospital gauze group (control group) by medical order; Composite medical pressure sensitive adhesive group prepared by embodiment 1 ~ 5.Observe 1 every day, record wound healing time, the results are shown in Table 2.
Table 2 wound healing time compares
。
In above-mentioned experiment, trier does not have obvious pungency and sense of discomfort in the meantime, and skin surface change is not obvious, does not occur to flood phenomenon.
Although embodiment of the present invention are open as above, but it is not restricted to listed in specification sheets and embodiment utilization, it can be applied to various applicable the field of the invention completely, for those skilled in the art, can easily realize other amendment, therefore do not deviating under the universal that claim and equivalency range limit, the present invention is not limited to specific details.
Claims (7)
1. a composite medical pressure sensitive adhesive, is characterized in that, by weight, comprise following component: ethyl α-cyanoacrylate 50 ~ 70 parts, dibutyl phthalate 10 ~ 25 parts, methacrylic acid 10 ~ 25 parts, alginates 5 ~ 15 parts, Common Cissampelos Herb extract 15 ~ 30 parts, liquidambar resinoid 1 ~ 10 part.
2. a kind of composite medical pressure sensitive adhesive according to claim 1, it is characterized in that, by weight, comprise following component: ethyl α-cyanoacrylate 58 ~ 64 parts, dibutyl phthalate 15 ~ 18 parts, methacrylic acid 18 ~ 22 parts, alginates 8 ~ 12 parts, Common Cissampelos Herb extract 23 ~ 25 parts, liquidambar resinoid 4 ~ 7 parts.
3. a kind of composite medical pressure sensitive adhesive according to claim 1, is characterized in that, by weight, comprise following component: ethyl α-cyanoacrylate 60 parts, dibutyl phthalate 16 parts, methacrylic acid 20 parts, alginates 10 parts, Common Cissampelos Herb extract 24 parts, liquidambar resinoid 6 parts.
4. a kind of composite medical pressure sensitive adhesive according to any one of claim 1 ~ 3, it is characterized in that, the extracting method of described Common Cissampelos Herb extract is as follows: after Common Cissampelos Herb crude drug extracting in water, concentrated, adding ethanol to the volumetric concentration ratio of ethanol is 40 ~ 60%, filter, get supernatant liquor, reclaim ethanol to ethanol contend concentration ratio lower than 2 ~ 5%.
5. a kind of composite medical pressure sensitive adhesive according to any one of claim 1 ~ 3, is characterized in that, described alginates is potassium alginate.
6. a kind of composite medical pressure sensitive adhesive according to any one of claim 1 ~ 3, is characterized in that, described liquidambar resinoid is Resina Liquidambaris wet distillation extract.
7. the preparation method of a kind of composite medical pressure sensitive adhesive according to claim 1, is characterized in that, comprise the steps:
(1) each component is taken by weight;
(2) by ethyl α-cyanoacrylate, dibutyl phthalate, methacrylic acid in mill mixing 25 ~ 40 minutes, again by alginates, Common Cissampelos Herb extract, liquidambar resinoid adds and continues mixing 25 ~ 30 minutes, make it dispersed, then be 40 ~ 50 DEG C with vulcanizing press at curing temperature, curing time is 2 ~ 4s, and sulfuration pressure is the composite pressure-sensitive adhesive being hot pressed into desired thickness under the condition of 4 ~ 6MPa.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510254532.2A CN104877578A (en) | 2015-05-19 | 2015-05-19 | Composite medical pressure-sensitive adhesive and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510254532.2A CN104877578A (en) | 2015-05-19 | 2015-05-19 | Composite medical pressure-sensitive adhesive and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105617442A (en) * | 2016-03-01 | 2016-06-01 | 苏州市贝克生物科技有限公司 | Adhesive for adhesive bandage and preparation method of adhesive |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0855191A2 (en) * | 1997-01-10 | 1998-07-29 | MedLogic Global Corporation | Methods for treating non-suturable, superficial wounds by use of cyanoacrylate ester compositions comprising an antimicrobial agent |
| CN1362982A (en) * | 1999-06-30 | 2002-08-07 | 科乐医药有限公司 | Flavored cyanoacrylate compositions |
| CN1378463A (en) * | 1999-08-12 | 2002-11-06 | 科乐医药有限公司 | Sterilized cyanoacrylate solutions containing thickeners |
-
2015
- 2015-05-19 CN CN201510254532.2A patent/CN104877578A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0855191A2 (en) * | 1997-01-10 | 1998-07-29 | MedLogic Global Corporation | Methods for treating non-suturable, superficial wounds by use of cyanoacrylate ester compositions comprising an antimicrobial agent |
| CN1362982A (en) * | 1999-06-30 | 2002-08-07 | 科乐医药有限公司 | Flavored cyanoacrylate compositions |
| CN1378463A (en) * | 1999-08-12 | 2002-11-06 | 科乐医药有限公司 | Sterilized cyanoacrylate solutions containing thickeners |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105617442A (en) * | 2016-03-01 | 2016-06-01 | 苏州市贝克生物科技有限公司 | Adhesive for adhesive bandage and preparation method of adhesive |
| CN105617442B (en) * | 2016-03-01 | 2019-02-19 | 苏州市贝克生物科技有限公司 | Adhesive bandage adhesive and preparation method thereof |
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Application publication date: 20150902 |