CN104857171A - Medicine composition for treating epigastric pain and application thereof - Google Patents

Abstract

The invention discloses a medicine composition for treating epigastric pain and application thereof. The medicine composition is prepared by traditional Chinese medicinal materials including, by mass, 30-45 parts of sweet potato vines, 19-28 parts of portulaca oleracea, 10-17 parts of chastetree fruits, 1.5-3 parts of garden balsams and 5-10 parts of polygala tenuifolia through water decoction and extraction. The medicine composition has remarkable treating effect on epigastric pain, all clinical symptoms are eliminated after a patient takes the medicine composition for 1-3 treatment courses, abdominal palpation is soft, resistance feeling and pressing pain are eliminated, percussion tympanic resonance is reduced and is gentle, coated tongue is thin and white, and pulse manifestation is moderate.

Description

A kind of pharmaceutical composition and application thereof for the treatment of abdominal pain

Technical field

The invention belongs to technical field of Chinese medicine, in particular to a kind of pharmaceutical composition and application thereof for the treatment of abdominal pain.

Background technology

Taste are hinges of human five internal organs's six internal organs ascending or descending movement of vital Qi, the reservoir of food and drink being also energy and blood of human body the source of vital function He depending on for existence.Abdominal distention great majority are gastropathy, belong to the de-pain of stomach, noisy, acid regurgitation category in the traditional Chinese medical science, and its pathogenesis is because liver stomach is become estranged, caused by weakness of the spleen and stomach, stagnation of liver-QI and stomach-QI, qi depression to blood stasis.Incoordination between the spleen and stomach, transport is uncomfortable often easily causes the symptoms such as stomachache, abdominal distention, loss of appetite, limbs asthenia, spiritlessness and weakness, cause the existing diet in life of these reason irregular, also have because operating pressure is large, the complicated psychological burden caused of inter personal contact is overweight, emotional lability etc.In recent years, the clinical onset rate of the spleen-stomach disease has the trend constantly risen.If do not added conditioning, also the symptoms such as gastric ulcer, gastric perforation, gastrorrhagia and chronic gastritis may be caused further.The Chinese patent medicine of current treatment gastropathy mainly contains WENWEISHU, YANGWEISHU, SANJIU WEITAI etc., although have certain curative effect to gastritis, all thoroughly can not cure targetedly gastropathy, is not suitable for the requirement that present stage treats this type of disease.

Summary of the invention

In view of the deficiencies in the prior art, the object of the present invention is to provide a kind of pharmaceutical composition and application thereof for the treatment of abdominal pain.In order to realize object of the present invention, inventor is studied by lot of experiments, finally obtains following technical scheme:

Treat a pharmaceutical composition for abdominal pain, be prepared from through water boiling and extraction by the Chinese crude drug of following mass parts: Caulis et Folium fici Tikouae 30-45 part, Herba portulacae 19-28 part, Fructus Viticis 10-17 part, Flos Impatientis 1.5-3 part, Radix Polygalae 5-10 part.

Preferably, the pharmaceutical composition of described treatment abdominal pain, is prepared from through water boiling and extraction by the Chinese crude drug of following mass parts: Caulis et Folium fici Tikouae 36-40 part, Herba portulacae 22-25 part, Fructus Viticis 12-15 part, Flos Impatientis 2-3 part, Radix Polygalae 6-8 part.

Further preferably, the pharmaceutical composition of described treatment abdominal pain, is prepared from through water boiling and extraction by the Chinese crude drug of following mass parts: Caulis et Folium fici Tikouae 38 parts, Herba portulacae 23 parts, Fructus Viticis 14 parts, Flos Impatientis 3 parts, Radix Polygalae 7 parts.

The pharmaceutical composition of any one treatment abdominal pain above-mentioned, it is made into oral formulations, comprises oral liquid, tablet, capsule and granule.

Compared with prior art, the medicine composite for curing abdominal pain that the present invention relates to evident in efficacy, after patient consumes 1-3 course for the treatment of, its clinical symptoms all disappears, abdominal touch is soft, and opposing sense disappears, and tenderness disappears, percussive tympany weakens and soft, thin white fur of tongue, and pulse condition eases up.In addition, this medicine also has advantages such as having no side effect, expense is lower.

Detailed description of the invention

Be below specific embodiments of the invention, technical scheme of the present invention is done to describing further, but protection scope of the present invention be not limited to these embodiments.Every do not deviate from the present invention's design change or equivalent substituting include within protection scope of the present invention.

It should be noted that, following examples of the present invention adopt the source of traditional Chinese medicinal material raw materials as follows: Caulis et Folium fici Tikouae selects the dry stem into moraceae plants Radix Pachyrhizi Erosi banyan Ficus tikoua Bur..Herba portulacae selects the dry herb of portulacaceous plant Herba Portulacae Portulaca oleracea L..Fructus Viticis selects the dry mature fruit of Verbenaceae Vitex rotundifolia Vitex trifolia L.var.simplicifolia Cham..Flos Impatientis selects the dry petal of Balsaminaceae plant Flos Impatientis Impatiens balsamina L..Radix Polygalae selects the dry root of milk wort ovum leaf Radix Polygalae Polygala sibirica L..

The preparation of embodiment 1 Chinese medicine oral liquid

Crude drug prescription: Caulis et Folium fici Tikouae 3.8kg, Herba portulacae 2.3kg, Fructus Viticis 1.4kg, Flos Impatientis 0.3kg, Radix Polygalae 0.7kg.

Preparation technology: the above-mentioned Chinese crude drug taking recipe quantity, merges, and pulverizes, adds water and cover powder 2cm, soak 1-1.2h, pull medical material out and put in multi-function extractor and decoct with water twice, first time adds up the water of medical material 12 times amount, decoct 3h, get decocting liquid, filter, second time adds up the water of medical material 10 times amount, decocts 2h, gets twice decocting liquid and merges, filter, be concentrated into every milliliter containing 1g crude drug amount, stir, put 5 DEG C of deepfreeze 24h, cold preservation liquid is filtered, obtains oral liquid.

The preparation of embodiment 2 Chinese medicine oral liquid

Crude drug prescription: Caulis et Folium fici Tikouae 4.5kg, Herba portulacae 2.5kg, Fructus Viticis 1.5kg, Flos Impatientis 0.3kg, Radix Polygalae 1.0kg.

Preparation technology: the above-mentioned Chinese crude drug taking recipe quantity, merges, and pulverizes, adds water and cover powder 2cm, soak 1-1.2h, pull medical material out and put during multi-functional extractions is filled with and decoct with water twice, first time totalling medical material 12 times amount water, decoct 3h, get decocting liquid, filter, second time adds up the water of medical material 10 times amount, decocts 2h, gets twice decocting liquid and merges, filter, be concentrated into every milliliter containing 1g crude drug amount, stir, put 5 DEG C of deepfreeze 24h, cold preservation liquid is filtered, obtains oral liquid.

Embodiment 3: Chinese medicine oral liquid is to the effectiveness study of abdominal pain patient

Abdominal pain patient 54 example, main manifestations is that all distensions of upper abdomen or umbilicus are uncomfortable, indigestion and loss of appetite or poor appetite; Some patients stomachache indistinctly, is felt sick or large dry stool but not constipated; Also have in patient's mouth and have taste, vow that gas is smelly dirty, belch etc.; Have a medical check-up and see that abdomen is smooth, upper abdomen palpation has opposing sense or tenderness, and without rebound tenderness, percussion major part is in tympanitic resonance, and borborygmus weakens relatively; Picture of the tongue is with teeth-printed tongue, and HUANGBAI(sic) thin coating is main, and pulse condition is how now heavy weak.In 54 routine patients, male 23 example, women 31 example; Age 32-68 year, average 42.5 ± 5.9 years old; The course of disease 1 month to 20 years, average 3.2 ± 0.8 years; Be divided into test group 27 example and matched group 27 example at random.The situations such as two groups of Genders, age, courses of disease compare, and through statistical analysis process, there was no significant difference, has comparability.After treatment starts, test group patient stops using other gastrointestinal drugs, only takes traditional Chinese medicine, and prescription forms: Caulis et Folium fici Tikouae 38g, Herba portulacae 23g, Fructus Viticis 14g, Flos Impatientis 3g, Radix Polygalae 7g.Every day 1 dose, decocting, early, middle and late each decoction being taken warmly 1 time.Matched group patient every day oral domperidone tablet 3 times, each 1 (10mg), withdraws other gastrointestinal drugs.Two groups of 10d that all take medicine, all to avoid eating anything raw or cold greasy and maror at treatments period.After treatment terminates, by following curative effect determinate standard Estimating curative effect: cure as clinical symptoms after taking medicine all disappears, abdominal touch is soft, opposing sense disappears, and tenderness disappears, and percussive tympany weakens and soft, and thin white fur of tongue, pulse condition eases up.Effectively for abdominal distention after taking medicine obviously alleviates, remaining disease or alleviate or disappear, abdominal touch opposing sense alleviates, and tenderness has and alleviates, or without obvious tenderness, percussive tympany weakens, thin white fur of tongue, and pulse condition is gentle.Invalid for taking medicine 10 days, curative effect does not reach responder.

After test group treatment, the statistical result of two groups of clinical efficacies is in table 1.Can be found out by the experimental result of table 1, test group clinical cure 11 example, accounts for 40.7%, and effective 15 examples, account for 55.6%, and invalid 1 example, accounts for 3.7%, total effective rate 96.3%.After treatment of control group, clinical cure 6 example, accounts for 22.2%; Effective 10 examples, account for 37.1%, and invalid 11 examples, account for 40.7%, total effective rate, 59.3%.Compare clinical cure rate and the total effective rate of two groups, the therapeutic effect of test group is obviously better than matched group.

Table 1 liang group Clinical efficacy comparison (example)

Model case: Lee, female, 46 years old, first visit on November 20 in 2012: discontinuity is had a stomachache, glutted 3 years.Patient is recurrent exerbation vague epigastralgia over 3 years, or scorching hot pain, acid regurgitation water, and singultus, does not give attention.Nearly 1 month scorching hot pain of gastral cavilty, coerce swollen, hypnalgia is very, glutted, lack of appetite, bitter taste, belch, time have acid regurgitation, red tongue with yellow fur, wiry and frequent pulse.Gastroscopy, is diagnosed as: gastric ulcer activity time.Take Chinese medicinal formulae of the present invention: Caulis et Folium fici Tikouae 38g, Herba portulacae 23g, Fructus Viticis 14g, Flos Impatientis 3g, Radix Polygalae 7g.10 doses, be decocted in water for oral dose, early, middle and late each decoction being taken warmly 1 time.Within 2012, December is examined for 03 day two: the scorching hot disappearance of gastral cavilty, and appetite increases, but diet satiety then accidental epigastric distending pain, have dull pain during night, still belch, tastelessness, red tongue has ecchymosis, white and thin fur, deep-thready pulse string.Card belong to hot and suffocating using pungent drugs for dispersion and bitter drugs for purgation, stagnation of QI-blood appears, gastric qi lose in fall.Continue to take Chinese medicinal formulae 10d of the present invention.Within 2012, December is examined for 18 days three: in high spirits turn of patient after clothes medicine-feeding, and appetite increases, and before sick, gastralgia, distension, all diseases of belch do not occur again.

Claims (5)

1. treat a pharmaceutical composition for abdominal pain, it is characterized in that described pharmaceutical composition is prepared from through water boiling and extraction by the Chinese crude drug of following mass parts: Caulis et Folium fici Tikouae 30-45 part, Herba portulacae 19-28 part, Fructus Viticis 10-17 part, Flos Impatientis 1.5-3 part, Radix Polygalae 5-10 part.

2. treat the pharmaceutical composition of abdominal pain according to claim 1, it is characterized in that described pharmaceutical composition is prepared from through water boiling and extraction by the Chinese crude drug of following mass parts: Caulis et Folium fici Tikouae 36-40 part, Herba portulacae 22-25 part, Fructus Viticis 12-15 part, Flos Impatientis 2-3 part, Radix Polygalae 6-8 part.

3. treat the pharmaceutical composition of abdominal pain according to claim 2, it is characterized in that described pharmaceutical composition is prepared from through water boiling and extraction by the Chinese crude drug of following mass parts: Caulis et Folium fici Tikouae 38 parts, Herba portulacae 23 parts, Fructus Viticis 14 parts, Flos Impatientis 3 parts, Radix Polygalae 7 parts.

4., according to the pharmaceutical composition of the arbitrary described treatment abdominal pain of claim 1-3, it is characterized in that: described pharmaceutical composition is made into oral formulations, comprise oral liquid, tablet, capsule and granule.

5. according to the application of the arbitrary described Chinese crude drug compositions of claim 1-3 in the medicine of preparation treatment abdominal distention abdominal pain.