CN104856967A - Encased tamper resistant controlled release dosage forms - Google Patents

Encased tamper resistant controlled release dosage forms Download PDF

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Publication number
CN104856967A
CN104856967A CN201510201680.8A CN201510201680A CN104856967A CN 104856967 A CN104856967 A CN 104856967A CN 201510201680 A CN201510201680 A CN 201510201680A CN 104856967 A CN104856967 A CN 104856967A
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dosage form
controlled release
hours
solid
release dosage
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CN201510201680.8A
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Chinese (zh)
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黄海涌
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普渡制药公司
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Priority to CN2011800615405A priority patent/CN103370058A/en
Publication of CN104856967A publication Critical patent/CN104856967A/en

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Abstract

The present invention relates to encased tamper resistant controlled release dosage forms. In certain embodiments, the present invention relates to a solid controlled release dosage form comprising: a core comprising a first portion of an opioid analgesic dispersed in a first matrix material; and a shell encasing the core and comprising a second portion of the opioid analgesic dispersed in a second matrix material; wherein the amount of opioid analgesic released from the dosage form is proportional within 20% to elapsed time from 8 to 24 hours, as measured by an in-vitro dissolution in a USP Apparatus 1 (basket) at 100 rpm in 900 ml simulated gastric fluid without enzymes (SGF) at 37 DEG C.

Description

包覆的抗篡改控制释放剂型 Tamper resistant coated controlled release dosage form

[0001] 本申请是申请日为2011年12月21日、申请号为"201180061540.5"、发明名称为"包覆的抗篡改控制释放剂型"的中国专利申请的分案申请,原申请是国际申请PCT/ IB2011/003152的中国国家阶段申请。 [0001] This application is filed on December 21, 2011, application number "201180061540.5" divisional application entitled "tamper resistant coated controlled release dosage form," the Chinese patent application, the original application is an international application PCT / Chinese national phase application IB2011 / 003152 of.

技术领域 FIELD

[0002] 本发明涉及抗篡改(tamper-resistant)的多层药物剂型并且优选地提供其中所包含活性剂的基本零级释放。 [0002] The present invention relates to a multilayer pharmaceutical dosage form an anti-tamper (tamper-resistant) and preferably provides substantially zero order release in which the active agent contained therein.

背景技术 Background technique

[0003] 药品有时是滥用的对象。 [0003] drugs are sometimes the object of abuse. 例如,与口服施用相同剂量相比,胃肠外施用时特定剂量的阿片样激动剂可更有效。 For example, compared to the same dose administered orally, parenteral administration of a particular dose of opioid agonist may be more effective. 一些制剂可被篡改以提供其中所包含的阿片样激动剂,用于非法使用。 Some formulations can be tampered with to provide the opioid agonist contained therein for illicit use. 控制释放阿片样激动剂制剂有时被药物滥用者压碎,或用溶剂(例如,乙醇)进行提取以提供其中所包含的阿片样物质用于在口服或胃肠外施用时立即释放。 Controlled release opioid agonist formulation are sometimes crushed by drug abusers, or extraction with a solvent (e.g., ethanol) to provide the opioid contained therein for immediate release upon oral or parenteral administration in.

[0004] 控制释放阿片样激动剂剂型可在接触乙醇时释放部分阿片样物质,如果患者无视使用说明书并且同时使用乙醇和所述剂型,则还可导致患者比预期更迅速地获得剂量。 [0004] The controlled release opioid agonist dosage forms part of the releasable opioid upon exposure to ethanol, and instructions for use if the patient simultaneously ignoring the ethanol and the dosage form, the patient may also result in more rapid access than the dose expected.

[0005] 美国专利申请公开No. 2009/0081290公开了抗篡改剂型,在某些实施方案中,其涉及包含片剂或多颗粒形式之延长释放基质制剂的固体口服延长释放药物剂型。 [0005] U.S. Patent Application Publication No. 2009/0081290 discloses a tamper resistant dosage forms, in certain embodiments, it relates to a particulate form of a tablet or extended release matrix formulation in the solid oral extended release pharmaceutical dosage form. 片剂或单个多颗粒可至少被压扁而不破碎,其特征在于被压扁后所述片剂或单个多颗粒的厚度相当于被压扁前所述片剂或单个多颗粒厚度的不超过约60%,并且其中,当在USP装置1 (篮) 中以IOOrpm在37°C下于900ml不含酶的模拟胃液(simulated gastric fluid,SGF)中测量时,对于溶出〇. 5小时时所释放活性剂的百分量,所述被压扁的片剂或被压扁的多颗粒提供的体外溶出速率与相应的未被压扁的参比片剂或参比多颗粒的体外溶出速率相比偏差不超过约20%点。 Tablet or the individual multi particulates can at least be flattened without breaking, characterized in that the flattening of the tablets or the individual multi particulates thickness before flattening, corresponds to the thickness of the tablet or the individual multi particulates is not more than about 60%, and wherein, when measured in a USP apparatus 1 (basket) at IOOrpm at 37 ° C for 900ml simulated gastric fluid without enzymes (simulated gastric fluid, SGF), for dissolution square. 5 hour period percent amount of active agent released in vitro dissolution rate of the plurality of particles flattened tablet or the flattened not provided with a corresponding flattened compared to a reference tablet or reference multi-vitro dissolution rate of the particles deviation of less than about 20% points.

[0006] 在本领域中有持续存在对抗篡改药物口服剂型的需要,其中所述剂型优选地提供基本为零级的活性剂的释放曲线。 [0006] There are continuing need exists against tampering oral dosage forms in the pharmaceutical art, wherein the dosage form preferably provides substantially zero order release profile of the active agent.

[0007] 就所有目的而言,本文中引用的所有参考文献和出版物通过引用整体并入。 [0007] for all purposes, all references and publications cited herein are entirely incorporated by reference.

发明内容 SUMMARY

[0008] 本发明的某些实施方案的一个目的是提供包含活性剂(例如,阿片样镇痛剂(opioid analgesic))的抗篡改的固体控制释放剂型(solid controlled release dosage form)〇 [0008] It is an object of certain embodiments of the present invention is provided comprising an active agent (e.g., opioid analgesic (opioid analgesic)) anti-tampering solid controlled release dosage form (solid controlled release dosage form) square

[0009] 本发明的某些实施方案的一个目的是提供包含活性剂(例如,阿片样镇痛剂)的抗压碎的固体控制释放剂型。 [0009] It is an object of certain embodiments of the present invention is provided comprising an active agent (e.g., opioid analgesic) anti crushed solid controlled release dosage form.

[0010] 本发明的某些实施方案的一个目的是提供包含阿片样镇痛剂的固体控制释放剂型,其比其他剂型更少地被肠胃外滥用。 [0010] It is an object of certain embodiments of the present invention to provide an opioid analgesic comprising a solid controlled release dosage form, which is less than the parenteral abuse of other dosage forms.

[0011] 本发明的某些实施方案的一个目的是提供包含阿片样镇痛剂的固体控制释放剂型,其比其他剂型更少地被鼻内滥用。 Solid [0011] It is an object of certain embodiments of the present invention to provide an opioid analgesic comprising a controlled release dosage form, which is less intranasal abuse than other dosage forms.

[0012] 本发明的某些实施方案的一个目的是提供包含阿片样镇痛剂的固体控制释放剂型,其比其他剂型更少地被口服滥用。 Solid [0012] It is an object of certain embodiments of the present invention to provide an opioid analgesic comprising a controlled release dosage form, which is less oral abuse than other dosage forms.

[0013] 本发明的某些实施方案的另一个目的是提供包含阿片样镇痛剂的固体控制释放剂型,其比其他剂型更少地被转移(diversion)。 Solid [0013] Another object of certain embodiments of the present invention to provide an opioid analgesic comprising a controlled release dosage form, which is less transferred (Diversion) than other dosage forms.

[0014] 本发明的某些实施方案的另一个目的是提供一种在人患者中用包含阿片样镇痛剂的固体控制释放剂型治疗疼痛同时降低所述剂型之滥用潜力的方法。 [0014] Another object of certain embodiments of the present invention is to provide a solid comprising an opioid analgesic in a human patient with controlled release dosage form for treating pain while reducing the abuse potential of the dosage form.

[0015] 本发明的某些实施方案的另一个目的是通过向有此需要的患者施用本文中公开的固体控制释放剂型来治疗疾病或病症(例如,疼痛)。 [0015] Another object of certain embodiments of the present invention is treated by administration of a controlled release solid dosage forms disclosed herein to a patient in need thereof a disease or condition (e.g., pain).

[0016] 本发明的某些实施方案的另一个目的是提供一种制备本文中公开的活性剂(例如,阿片样镇痛剂)之口服剂型的方法。 [0016] Another object of certain embodiments of the present invention is to provide an active agent (e.g., opioid analgesic) disclosed herein, the method of preparing an oral dosage form.

[0017] 本发明的某些实施方案的另一个目的是提供药物(例如,阿片样镇痛剂)在制备用于治疗疾病状态(例如,疼痛)之剂型中的用途。 [0017] Another object of certain embodiments of the present invention is the use to provide a drug (e.g., opioid analgesic) in preparation for treating a disease state (e.g., pain) of the dosage form.

[0018] 通过本发明完成了这些目的和另一些目的,在某些实施方案中,本发明涉及包含核心(core)和壳(shell)的固体控制释放剂型,所述核心包含分散在第一基质材料中的第一部分活性剂(例如,阿片样镇痛剂),所述壳包覆(encase)所述核心并且包含分散在第二基质材料中的第二部分所述活性剂;其中,如通过在USP装置1(篮)中以IOOrpm在37°C 下于900ml不含酶的模拟胃液(SGF)中体外溶(SGF)中体外溶出所测量的,从所述剂型释放的活性剂的量在8至24小时与经过时间(elapsed time)在20%内成比例。 [0018] The present invention is accomplished by these objects and other objects, in certain embodiments, the present invention relates to a solid core (Core) and the shell (the shell) a controlled release dosage form, the core comprises a first dispersed in a matrix a first portion of the active material in the agent (e.g., opioid analgesic), a housing cover (EnCase) comprising a second portion of the core and the active agent dispersed in a second matrix material; wherein, e.g., by in a USP apparatus 1 (basket) at IOOrpm at 37 ° C for 900ml simulated gastric fluid without enzymes (SGF) in vitro was dissolved (SGF) measured in vitro dissolution, releases an amount of active agent from the dosage form in 8-24 hours elapsed time (elapsed time) is proportional to within 20%.

[0019] 在某些其他的实施方案中,如通过在USP装置1(篮)中以IOOrpm在37 °C下于900ml不含酶的模拟胃液(SGF)中体外溶出所测量的,从所述剂型释放的活性剂的量在(i)4至24小时、(ii)8至24小时、(iii) 12至24小时、(iv) 18至24小时、(v)4至8小时、 (vi)4至12小时、(vii)4至18小时、(viii)8至12小时、(ix)8至18小时或(X) 12至18 小时中至少一个与经过时间在30%内成比例。 [0019] In certain other embodiments, such as by the USP Apparatus 1 (basket) at IOOrpm at 37 ° C for 900ml simulated gastric fluid without enzymes (SGF) measured in vitro dissolution, from the the amount of active agent in the dosage form released in the (i) 4 to 24 hours, (ii) 8 to 24 hours, (iii) 12 to 24 hours, (iv) 18 to 24 hours, (v) 4 to. 8 hours, (vi ) from 4 to 12 hours, (VII) the 4- to 18 is hours, (viii) 8 to 12 is hours, (ix) 8 to 18 is hours, or (X) 12 to 18 is hours at least one of elapsed time of 30% by proportional. 在一些替代实施方案中,如通过在USP装置1(篮)中以IOOrpm在37°C下于900ml不含酶的模拟胃液(SGF)中体外溶出所测量的,从所述剂型释放的活性剂的量在(i)8至24小时、(ii)8至12小时和(iii)8至18小时与经过时间均在30 %内成比例。 In alternative embodiments, such as by the USP Apparatus 1 (basket) at IOOrpm at 37 ° C for 900ml simulated gastric fluid without enzymes (SGF) as measured in vitro dissolution, release of active agent from the dosage form the amount of (i) 8 to 24 hours, (ii) 8 12.0 hour, (iii) 8 to 18 is the clock and the elapsed time was within 30% of the proportional.

[0020] 在某些其他的实施方案中,如通过在USP装置1(篮)中以IOOrpm在37 °C下于900ml不含酶的模拟胃液(SGF)中体外溶出所测量的,从所述剂型释放的活性剂的量在(i)4至24小时、(ii)8至24小时、(iii) 12至24小时、(iv) 18至24小时、(v)4至8小时、 (vi)4至12小时、(vii)4至18小时、(viii)8至12小时、(ix)8至18小时或(X) 12至18 小时中至少一个与经过时间在25%内成比例。 [0020] In certain other embodiments, such as by the USP Apparatus 1 (basket) at IOOrpm at 37 ° C for 900ml simulated gastric fluid without enzymes (SGF) measured in vitro dissolution, from the the amount of active agent in the dosage form released in the (i) 4 to 24 hours, (ii) 8 to 24 hours, (iii) 12 to 24 hours, (iv) 18 to 24 hours, (v) 4 to. 8 hours, (vi ) from 4 to 12 hours, (VII) the 4- to 18 is hours, (viii) 8 to 12 is hours, (ix) 8 to 18 is hours, or (X) 12 to 18 is hours at least one of elapsed time to within 25% of the proportion. 在一些替代实施方案中,如通过在USP装置1(篮)中以IOOrpm在37°C下于900ml不含酶的模拟胃液(SGF)中体外溶出所测量的,从所述剂型释放的活性剂的量在(i)8至24小时、(ii)8至12小时和(iii)8至18小时与经过时间均在25%内成比例。 In alternative embodiments, such as by the USP Apparatus 1 (basket) at IOOrpm at 37 ° C for 900ml simulated gastric fluid without enzymes (SGF) as measured in vitro dissolution, release of active agent from the dosage form the amount of (i) 8 to 24 hours, (ii) 8 12.0 hour, (iii) 8 to 18 is the clock and the elapsed time was within 25% of the proportional.

[0021] 在某些其他的实施方案中,如通过在USP装置1(篮)中以IOOrpm在37 °C下于900ml不含酶的模拟胃液(SGF)中体外溶出所测量的,从所述剂型释放的活性剂的量在(i)4至24小时、(ii)8至24小时、(iii) 12至24小时、(iv) 18至24小时、(v)4至8小时、 (vi)4至12小时、(vii)4至18小时、(viii)8至12小时、(ix)8至18小时或(X) 12至18 小时中至少一个与经过时间在20%内成比例。 [0021] In certain other embodiments, such as by the USP Apparatus 1 (basket) at IOOrpm at 37 ° C for 900ml simulated gastric fluid without enzymes (SGF) measured in vitro dissolution, from the the amount of active agent in the dosage form released in the (i) 4 to 24 hours, (ii) 8 to 24 hours, (iii) 12 to 24 hours, (iv) 18 to 24 hours, (v) 4 to. 8 hours, (vi ) from 4 to 12 hours, (VII) the 4- to 18 is hours, (viii) 8 to 12 is hours, (ix) 8 to 18 is hours, or (X) 12 to 18 is hours at least one of elapsed time within 20% in proportion. 在一些替代实施方案中,如通过在USP装置1(篮)中以IOOrpm在37°C下于900ml不含酶的模拟胃液(SGF)中体外溶出所测量的,从所述剂型释放的活性剂的量在(i)8至24小时、(ii)8至12小时和(iii)8至18小时与经过时间均在20 %内成比例。 In alternative embodiments, such as by the USP Apparatus 1 (basket) at IOOrpm at 37 ° C for 900ml simulated gastric fluid without enzymes (SGF) as measured in vitro dissolution, release of active agent from the dosage form the amount of (i) 8 to 24 hours, (ii) 8 12.0 hour, (iii) 8 to 18 is the clock and the elapsed time was within 20% proportional.

[0022] 在某些其他的实施方案中,如通过在USP装置1(篮)中以IOOrpm在37 °C下于900ml不含酶的模拟胃液(SGF)中体外溶出所测量的,从所述剂型释放的活性剂的量在(i)4至24小时、(ii)8至24小时、(iii) 12至24小时、(iv) 18至24小时、(v)4至8小时、 (vi)4至12小时、(vii)4至18小时、(viii)8至12小时、(ix)8至18小时或(X) 12至18 小时中至少一个与经过时间在10%内成比例。 [0022] In certain other embodiments, such as by the USP Apparatus 1 (basket) at IOOrpm at 37 ° C for 900ml simulated gastric fluid without enzymes (SGF) measured in vitro dissolution, from the the amount of active agent in the dosage form released in the (i) 4 to 24 hours, (ii) 8 to 24 hours, (iii) 12 to 24 hours, (iv) 18 to 24 hours, (v) 4 to. 8 hours, (vi ) from 4 to 12 hours, (VII) the 4- to 18 is hours, (viii) 8 to 12 is hours, (ix) 8 to 18 is hours, or (X) 12 to 18 is hours at least one of elapsed time to within 10% of the proportion. 在一些替代实施方案中,如通过在USP装置1(篮)中以IOOrpm在37°C下于900ml不含酶的模拟胃液(SGF)中体外溶出所测量的,从所述剂型释放的活性剂的量在(i)8至24小时、(ii)8至12小时和(iii)8至18小时与经过时间均在10 %内成比例。 In alternative embodiments, such as by the USP Apparatus 1 (basket) at IOOrpm at 37 ° C for 900ml simulated gastric fluid without enzymes (SGF) as measured in vitro dissolution, release of active agent from the dosage form the amount of (i) 8 to 24 hours, (ii) 8 12.0 hour, (iii) 8 to 18 is the clock and the elapsed time was within 10% proportional.

[0023] 在某些其他的实施方案中,如通过在USP装置1(篮)中以IOOrpm在37 °C下于900ml不含酶的模拟胃液(SGF)中体外溶出所测量的,从所述剂型释放的活性剂的量在(i)4至24小时、(ii)8至24小时、(iii) 12至24小时、(iv) 18至24小时、(v)4至8小时、 (vi)4至12小时、(vii)4至18小时、(viii)8至12小时、(ix)8至18小时或(X) 12至18 小时中至少一个与经过时间存在5%的比例关系。 [0023] In certain other embodiments, such as by the USP Apparatus 1 (basket) at IOOrpm at 37 ° C for 900ml simulated gastric fluid without enzymes (SGF) measured in vitro dissolution, from the the amount of active agent in the dosage form released in the (i) 4 to 24 hours, (ii) 8 to 24 hours, (iii) 12 to 24 hours, (iv) 18 to 24 hours, (v) 4 to. 8 hours, (vi at least one proportional to the elapsed time presence of 5%) of 4-12 hours, (VII) the 4- to 18 is hours, (viii) 8 to 12 is hours, (ix) 8 to 18 is hours, or (X) 12 to 18 is hours. 在一些替代实施方案中,如通过在USP装置1(篮)中以IOOrpm在37°C下于900ml不含酶的模拟胃液(SGF)中体外溶出所测量的, 从所述剂型释放的活性剂的量在(i)8至24小时、(ii)8至12小时和(iii)8至18小时与经过时间均在5 %内成比例。 In alternative embodiments, such as by the USP Apparatus 1 (basket) at IOOrpm at 37 ° C for 900ml simulated gastric fluid without enzymes (SGF) as measured in vitro dissolution, release of active agent from the dosage form the amount of (i) 8 to 24 hours, (ii) 8 12.0 hour, (iii) 8 to 18 is the clock and the elapsed time was within 5% in proportion.

[0024] 在某些实施方案中,本发明涉及包含核心和壳的固体控制释放剂型,所述核心包含分散在包含聚环氧乙烷之第一基质材料中的第一部分活性剂(例如,阿片样镇痛剂),所述壳包覆所述核心并且包含分散在包含聚环氧乙烷之第二基质材料中的第二部分所述活性剂。 [0024] In certain embodiments, the present invention relates to a solid comprising a core and a shell of controlled release dosage form, dispersed in said core comprises an active agent comprising a first portion of the first matrix material is polyethylene oxide (e.g., opioid comp analgesic), the shell covering the core and comprising a second portion of the active agent is dispersed in a second matrix material comprises polyethylene oxide in. 在一些替代实施方案中,仅所述第一基质材料包含聚环氧乙烷或仅所述第二基质材料包含聚环氧乙烷。 In alternative embodiments, only the first matrix material comprises polyethylene oxide or only the second matrix material comprises polyethylene oxide.

[0025] 在某些实施方案中,本发明涉及包含压制核心(compressed core)和压制包衣(compression coating)的固体控制释放剂型,所述核心包含分散在包含聚环氧乙烧之第一基质材料中的第一部分活性剂(例如,阿片样镇痛剂),所述包衣包覆所述核心并且包含分散在包含聚环氧乙烷之第二基质材料中的第二部分所述活性剂。 [0025] In certain embodiments, the present invention relates to a press comprising a core (compressed core) and pressing the solid coating (compression coating) a controlled release dosage form, the core comprises a first dispersed in a matrix comprising polyethylene oxide of burning B a first portion of the active material in the agent (e.g., opioid analgesic), the coating covering the core and comprising a second portion of the active agent is dispersed in a second matrix material comprising a polyethylene oxide in the .

[0026] 在某些实施方案中,本发明涉及包含核心和壳的固体控制释放剂型,所述核心包含分散在第一基质材料中的第一部分活性剂(例如,阿片样镇痛剂),所述壳包覆所述核心并且包含分散在第二基质材料中的第二部分所述活性剂;其中,如通过在USP装置1 (篮) 中以IOOrpm在37°C下于900ml不含酶的模拟胃液(SGF)中体外溶出所测量的,在2小时时从所述剂型释放的活性剂的量小于约25% ;在4小时时从所述剂型释放的活性剂的量为约10%至约30% ;在8小时时从所述剂型释放的活性剂的量为约20%至约60% ;在12小时时从所述剂型释放的活性剂的量为约40%至约90% ;并且在18小时时从所述剂型释放的活性剂的量大于约70%。 [0026] In certain embodiments, the present invention relates to a solid comprising a core and a shell of controlled release dosage form, the core comprises a first portion of the first active agent is dispersed in the matrix material (e.g., opioid analgesic), the said shell covering the core and comprising a second portion of the active agent is dispersed in a second matrix material; wherein, as measured by the USP apparatus 1 (basket) at 37 ° C for at IOOrpm in 900ml without enzymes simulated gastric fluid (SGF) as measured in vitro dissolution at 2 hours from the dosage form release an amount of the active agent is less than about 25%; 4 hours the amount of released active agent from the dosage form from about 10% to about 30%; 8 hours in an amount of release of active agent from the dosage form is from about 20% to about 60%; at 12 hours the amount of release of active agent from the dosage form is from about 40% to about 90%; at 18 hours and the amount of released active agent from the dosage form in about 70%.

[0027] 在某些实施方案中,本发明涉及包含核心和壳的固体控制释放剂型,所述核心包含分散在第一基质材料中的第一部分活性剂(例如,阿片样镇痛剂),所述壳包覆所述核心并且包含分散在第二基质材料中的第二部分所述活性剂;其中,如通过在USP装置I (篮) 中以IOOrpm在37°C下于900ml不含酶的模拟胃液(SGF)中体外溶出所测量的,在2小时时从所述剂型释放的活性剂的量小于约20% ;在4小时时从所述剂型释放的活性剂的量为约10%至约30% ;在8小时时从所述剂型释放的活性剂的量为约30%至约60% ;在12小时时从所述剂型释放的活性剂的量为约50%至约90% ;并且在18小时时从所述剂型释放的活性剂的量大于约80%。 [0027] In certain embodiments, the present invention relates to a solid comprising a core and a shell of controlled release dosage form, the core comprises a first portion of the first active agent is dispersed in the matrix material (e.g., opioid analgesic), the said shell covering the core and comprising a second portion of the active agent is dispersed in a second matrix material; wherein, as measured by the USP apparatus I (basket) to IOOrpm at 37 ° C for at 900ml without enzymes simulated gastric fluid (SGF) as measured in vitro dissolution, the amount released at 2 hours from the dosage form of the active agent is less than about 20%; 4 hours the amount of released active agent from the dosage form from about 10% to about 30%; 8 hours in an amount of release of active agent from the dosage form is from about 30% to about 60%; at 12 hours the amount of release of active agent from the dosage form is from about 50% to about 90%; and the amount of active agent released at 18 hours from the dosage form at about 80%.

[0028] 在某些实施方案中,本发明涉及包含核心和壳的固体控制释放剂型,所述核心包含分散在第一基质材料中的第一部分活性剂(例如,阿片样镇痛剂),所述壳包覆所述核心并且包含分散在第二基质材料中的第二部分所述活性剂;其中,如通过在USP装置1 (篮) 中以IOOrpm在37°C下于900ml不含酶的模拟胃液(SGF)中体外溶出所测量的,在2小时时从所述剂型释放的活性剂的量小于约15% ;在4小时时从所述剂型释放的活性剂的量为约8%至约20% ;在8小时时从所述剂型释放的活性剂的量为约20%至约50% ;在12小时时从所述剂型释放的活性剂的量为约40%至约70% ;在18小时时从所述剂型释放的活性剂的量大于约70% ;并且在24小时时从所述剂型释放的活性剂的量大于约90%。 [0028] In certain embodiments, the present invention relates to a solid comprising a core and a shell of controlled release dosage form, the core comprises a first portion of the first active agent is dispersed in the matrix material (e.g., opioid analgesic), the said shell covering the core and comprising a second portion of the active agent is dispersed in a second matrix material; wherein, as measured by the USP apparatus 1 (basket) at 37 ° C for at IOOrpm in 900ml without enzymes simulated gastric fluid (SGF) as measured in vitro dissolution, the amount released at 2 hours from the dosage form of the active agent is less than about 15%; 4 hours the amount of released active agent from the dosage form is from about 8% to about 20%; 8 hours in an amount of release of active agent from the dosage form is from about 20% to about 50%; at 12 hours the amount of release of active agent from the dosage form is from about 40% to about 70%; released at 18 hours amount of the active agent from the dosage form in about 70%; at 24 hours and the amount of released active agent from the dosage form in about 90%. 在某些实施方案中,本发明涉及包含治疗有效量的氢可酮或其可药用盐和控制释放赋形剂的固体控制释放剂型;其中,如通过在USP装置1(篮)中以IOOrpm在37°C下于900ml不含酶的模拟胃液(SGF)中体外溶出所测量的,从所述剂型释放的阿片样镇痛剂的量在8至24小时与经过时间在20%内成比例;并且所述剂型可被压扁而不破碎,其中被压扁后所述剂型的厚度相当于被压扁前所述剂型厚度的不超过约20% ;如通过在USP装置1(篮)中以IOOrpm 在37°C下于900ml不含酶的模拟胃液(SGF)中体外溶出所测量的,在0. 5小时时从被压扁剂型释放的氢可酮或其盐的量与未被压扁剂型相比偏差不超过约20%点。 In certain embodiments, the present invention relates to a therapeutically effective amount of hydrocodone or a pharmaceutically acceptable salt thereof and controlled release solid excipient controlled release dosage form; wherein, as by in a USP Apparatus 1 (basket) IOOrpm at 37 ° C for at 900ml simulated gastric fluid without enzymes (SGF) measured in vitro dissolution, the amount of opioid analgesic released from the dosage form at 8 to 24 hours elapsed time and 20% in proportion to the ; and the dosage form can be flattened without breaking, wherein a thickness of the dosage form after the flattening which corresponds to no more than about 20% of the dosage form before flattening thickness; as measured by the USP apparatus (basket) 1 in IOOrpm at 37 ° C for at 900ml simulated gastric fluid without enzymes (SGF) as measured in vitro dissolution, at 0.5 hours from the dosage form releases flattened hydrocodone or a salt thereof in an amount of not pressed flat dosage form as compared to deviation of less than about 20% points.

[0029] 在某一个实施方案中,本发明涉及包含治疗有效量的氢可酮或其可药用盐和控制释放赋形剂的固体控制释放剂型;其中,如通过在USP装置1 (篮)中以IOOrpm在37°C下于900ml不含酶的模拟胃液(SGF)中体外溶出所测量的,在2小时时从所述剂型释放的氢可酮或其盐的量小于约25%;在4小时时从所述剂型释放的氢可酮或其盐的量为约10%至约30%;在8小时时从所述剂型释放的氢可酮或其盐的量为约20%至约60%;在12小时时从所述剂型释放的氢可酮或其盐的量为约40%至约90% ;并且在18小时时从所述剂型释放的氢可酮或其盐的量大于约70% ;并且所述剂型可被压扁而不破碎,其中被压扁后所述剂型的厚度相当于被压扁前所述剂型厚度的不超过约20%;并且如通过在USP装置1 (篮) 中以IOOrpm在37°C下于900ml不含酶的模拟胃液(SGF)中体外溶出所测量的,在0. 5小时时从被压扁剂型释放的 [0029] In one embodiment, the present invention relates to a therapeutically effective amount of hydrocodone or a pharmaceutically acceptable salt thereof and controlled release solid dosage form of controlled release excipient; wherein, as measured by the USP Apparatus 1 (basket) to IOOrpm at 37 ° C for 900ml simulated gastric fluid without enzymes (SGF) measured in vitro dissolution, the amount released at 2 hours from the dosage form of hydrocodone or a salt thereof is less than about 25%; in 4 hours from the dosage form the amount of oxycodone released hydrogen or a salt thereof is from about 10% to about 30%; released at 8 hours from the dosage form of hydrocodone or a salt thereof in an amount of from about 20% to about 60%; 12 hours the amount released from the dosage form of hydrocodone or salt thereof from about 40% to about 90%; at 18 hours and released from the dosage form of hydrocodone or a salt thereof is greater than about 70%; and the dosage form can be flattened without breaking, wherein a thickness of the dosage form after the flattening which corresponds to the dosage form before flattening a thickness no more than about 20%; and such as by USP apparatus 1 (basket) to IOOrpm at 37 ° C for 900ml simulated gastric fluid without enzymes (SGF) as measured in vitro dissolution, at 0.5 hours released from the dosage form is crushed 氢可酮或其盐的量与未被压扁剂型相比偏差不超过约20%点。 Amount of hydrocodone or a salt thereof as compared to the non-compressed dosage form deviation of less than about 20% points.

[0030] 在某些实施方案中,本发明涉及包含分散在控制释放赋形剂中的治疗有效量的氢可酮或其可药用盐的固体控制释放剂型;其中所述剂型的内部60%包含至少80%的氢可酮或其盐;其中,如通过在USP装置1(篮)中以IOOrpm在37°C下于900ml不含酶的模拟胃液(SGF)中体外溶出所测量的,从所述剂型释放的氢可酮或其盐的量在8至24小时与经过时间在20%内成比例。 [0030] In certain embodiments, the present invention relates to a controlled release excipient dispersed in the treatment of an effective amount of hydrocodone or a pharmaceutically acceptable salt thereof solid controlled release dosage form; wherein the interior of the dosage form 60% hydrogen comprising at least 80% of oxycodone or a salt thereof; wherein, as in USP apparatus 1 (basket) at IOOrpm at 37 ° C for 900ml simulated gastric fluid without enzymes (SGF) in-vitro dissolution as measured by, from the dosage form releases an amount of hydrocodone or salt thereof and from 8 to 24 hours elapsed time is proportional to within 20%.

[0031] 在某些实施方案中,本发明涉及制备固体控制释放剂型的方法,其包括:制备核心,其包含分散在第一基质材料中的第一部分活性剂(例如,阿片样镇痛剂);以及将所述核心包覆在壳中,所述壳包含分散在第二基质材料中的第二部分所述活性剂;其中,如通过在USP装置1(篮)中以IOOrpm在37°C下于900ml不含酶的模拟胃液(SGF)中体外溶出所测量的,从所述剂型释放的活性剂的量在8至24小时与经过时间在20%内成比例。 [0031] In certain embodiments, the present invention relates to a method for preparing a solid controlled release dosage form, comprising: preparing a core, a first portion comprising an active agent dispersed in a first matrix material (e.g., opioid analgesic) ; and coating the core in the shell, said shell comprising a second portion of the active agent dispersed in a second matrix material; wherein, as by IOOrpm at 37 ° C in a USP apparatus 1 (basket) simulated gastric fluid (SGF) under a 900ml without enzymes in vitro dissolution measured, the elapsed time is within 20% in proportion to the amount of the dosage form of active agent released in 8-24 hours.

[0032] 在某些实施方案中,本发明涉及制备固体控制释放剂型的方法,其包括:制备核心,其包含分散在包含聚环氧乙烷之第一基质材料中的第一部分活性剂(例如,阿片样镇痛剂);以及将所述核心包覆在壳中,所述壳包含分散在包含聚环氧乙烷之第二基质材料中的第二部分所述活性剂。 [0032] In certain embodiments, the present invention relates to a method for preparing a solid controlled release dosage form, comprising: preparing a core, a first portion comprising an active agent dispersed in a first matrix material comprising polyethylene oxide (e.g. , opioid analgesic); and coating the core in the shell, said shell comprising a second portion of the active agent dispersed in a second matrix material comprises polyethylene oxide in. 在一些替代实施方案中,制备相应的剂型,使得仅所述第一基质材料包含聚环氧乙烷或仅所述第二基质材料包含聚环氧乙烷。 In alternative embodiments, to prepare the corresponding dosage form, such that only the first matrix material comprises polyethylene oxide or only the second matrix material comprises polyethylene oxide.

[0033] 在某些实施方案中,本发明涉及制备固体控制释放剂型的方法,其包括:制备压制核心,其包含分散在包含聚环氧乙烷之第一基质材料中的第一部分活性剂(例如,阿片样镇痛剂);以及通过在所述核心上以包含分散在包含聚环氧乙烷之第二基质材料中的第二部分所述活性剂压制包衣来包覆所述核心。 [0033] In certain embodiments, the present invention relates to a method for preparing a solid controlled release dosage form, comprising: preparing a compressed core comprising a first part comprising a dispersion of an active agent in a first matrix material is polyethylene oxide ( e.g., opioid analgesic); and by the core to comprise dispersed in a second matrix material comprises polyethylene oxide in the second portion of the active agent to coat said core press-coated. 在一些替代实施方案中,制备相应的压制包衣剂型,使得仅所述第一基质材料包含聚环氧乙烷或仅所述第二基质材料包含聚环氧乙烷。 In alternative embodiments, to prepare the corresponding press-coated dosage forms, such that only the first matrix material comprises polyethylene oxide or only the second matrix material comprises polyethylene oxide. [0034] 在某些实施方案中,本发明涉及制备固体控制释放剂型的方法,包括:制备核心, 其包含分散在第一基质材料中的第一部分活性剂(例如,阿片样镇痛剂);以及将所述核心包覆在壳中,所述壳包含分散在所述核心上第二基质材料中的第二部分所述活性剂;其中, 如通过在USP装置1(篮)中以IOOrpm在37°C下于900ml不含酶的模拟胃液(SGF)中体外溶出所测量的,在2小时时从所述剂型释放的活性剂的量小于约25% ;在4小时时从所述剂型释放的活性剂的量为约10%至约30%;在8小时时从所述剂型释放的活性剂的量为约20%至约60% ;在12小时时从所述剂型释放的活性剂的量为约40%至约90% ;并且在18 小时时从所述剂型释放的活性剂的量大于约70 %。 [0034] In certain embodiments, the present invention relates to a method for preparing a solid controlled release dosage form, comprising: preparing a core, a first portion comprising an active agent dispersed in a first matrix material (e.g., opioid analgesic); and coating the core in the shell, the shell comprises a second portion of the active agent is dispersed in the matrix material of the second core; wherein, as measured by the USP apparatus (basket) at 1 to IOOrpm in 900ml of simulated gastric fluid without enzymes at 37 ° C (SGF) measured in vitro dissolution, the amount released at 2 hours from the dosage form of the active agent is less than about 25%; released from the dosage form at 4 hours amount of the active agent is from about 10% to about 30%; 8 hours in an amount of release of active agent from the dosage form is from about 20% to about 60%; at 12 hour release of active agent from the dosage form in an amount of from about 40% to about 90%; at 18 hours and the amount of released active agent from the dosage form in about 70%.

[0035] 在某些实施方案中,本发明涉及制备固体控制释放剂型的方法,其包括将治疗有效量的氢可酮或其可药用盐与控制释放赋形剂相组合;其中,如通过在USP装置1 (篮)中以IOOrpm在37°C下于900ml不含酶的模拟胃液(SGF)中体外溶出所测量的,在2小时时从所述剂型释放的氢可酮或其盐的量小于约25% ;在4小时时从所述剂型释放的氢可酮或其盐的量为约10%至约30% ;在8小时时从所述剂型释放的氢可酮或其盐的量为约20% 至约60% ;在12小时时从所述剂型释放的氢可酮或其盐的量为约40%至约90% ;并且在18小时时从所述剂型释放的氢可酮或其盐的量大于约70 %;并且所述剂型可被压扁而不破碎,其中被压扁后所述剂型的厚度相当于被压扁前所述剂型厚度的不超过约20% ;并且,如通过在USP装置1(篮)中以IOOrpm在37°C下于900ml不含酶的模拟胃液(SGF)中体外溶出所测量的,在〇. 5 [0035] In certain embodiments, the present invention relates to a method for preparing a solid controlled release dosage form, which comprises a therapeutically effective amount of hydrocodone or a pharmaceutically acceptable salt thereof in combination with the controlled release excipient; wherein, e.g., by in a USP apparatus 1 (basket) at IOOrpm at 37 ° C for 900ml simulated gastric fluid without enzymes (SGF) as measured in vitro dissolution at 2 hours is released from the dosage form of hydrocodone or a salt thereof less than about 25%; the amount released at 4 hours from the dosage form of hydrocodone or salt thereof from about 10% to about 30%; released at 8 hours from the dosage form of hydrocodone or a salt thereof in an amount of from about 20% to about 60%; at 12 hours released from the dosage form of hydrocodone or salt thereof from about 40% to about 90%; at 18 hours and released from the dosage form of hydrocodone -one or salts is greater than about 70%; and the dosage form can be flattened without breaking, wherein a thickness of the dosage form after the flattening which corresponds to the dosage form before flattening a thickness no more than about 20%; Further, as by the USP apparatus 1 (basket) at IOOrpm at 37 ° C for 900ml simulated gastric fluid without enzymes (SGF) as measured in vitro dissolution, in the square. 5 时时从被压扁剂型释放的氢可酮或其盐的量与未被压扁剂型相比偏差不超过约20%点。 Always released from the dosage form is crushed hydrocodone or a salt thereof in an amount dosage compared to the non flattening deviation is less than about 20% points.

[0036] 在某一个实施方案中,本发明涉及制备固体控制释放剂型的方法,其包括将治疗有效量的氢可酮或其可药用盐与控制释放赋形剂相组合;其中,如通过在USP装置1 (篮) 中以IOOrpm在37°C下于900ml不含酶的模拟胃液(SGF)中体外溶出所测量的,从所述剂型释放的氢可酮或其盐的量在8至24小时中任意两个时间点与经过时间在20%内成比例; 并且所述剂型可被压扁而不破碎,其中被压扁后所述剂型的厚度相当于被压扁前所述剂型厚度的不超过约20% ;并且,如通过在USP装置1(篮)中以IOOrpm在37°C下于900ml不含酶的模拟胃液(SGF)中体外溶出所测量的,在0.5小时时从被压扁剂型释放的氢可酮或其盐的量与未被压扁剂型相比偏差不超过约20 %点。 [0036] In one embodiment, the present invention relates to a method for preparing a solid controlled release dosage form, which comprises a therapeutically effective amount of hydrocodone or a pharmaceutically acceptable salt thereof in combination with the controlled release excipient; wherein, e.g., by in a USP apparatus 1 (basket) at 37 ° C for at IOOrpm in 900ml of simulated gastric fluid without enzymes (SGF) as measured in vitro dissolution, release from the dosage form of hydrocodone or a salt thereof in an amount of 8 to 24 hours at any two points in time and the elapsed time is proportional to within 20%; and the dosage form can be flattened without breaking, wherein a thickness of the dosage form after the flattening which corresponds to the thickness of the dosage form before flattening, no more than about 20%; and, as by IOOrpm at 37 ° C for 900ml simulated gastric fluid without enzymes (SGF) as measured in vitro dissolution in a USP apparatus 1 (basket), and at 0.5 hours from the flattening release dosage form of hydrocodone or a salt thereof in an amount dosage compared to the non flattening deviation is less than about 20% points.

[0037] 在某些实施方案中,本发明涉及制备固体控制释放剂型的方法,其包括将治疗有效量的氢可酮或其可药用盐分散到控制释放赋形剂中;其中所述剂型的内部60%包含至少80 %的所述氢可酮或其盐;其中,如通过在USP装置1(篮)中以IOOrpm在37°C下于900ml不含酶的模拟胃液(SGF)中体外溶出所测量的,从所述剂型释放的氢可酮或其盐的量在8至24小时与经过时间在20%内成比例。 [0037] In certain embodiments, the present invention relates to a method for preparing a solid controlled release dosage form, which comprises a therapeutically effective amount of hydrocodone or a pharmaceutically acceptable salt thereof dispersed in a controlled release excipient; wherein said dosage form 60% of the interior of the hydrogen containing at least 80% of oxycodone or a salt thereof; wherein, e.g., by in vitro 1 (basket) to the USP apparatus IOOrpm 37 ° C for 900ml simulated gastric fluid without enzymes (SGF) the dissolution measured, the amount of oxycodone released hydrogen from the dosage form or its salt in 8-24 hours and in 20% of the elapsed time is proportional.

[0038] 在某些实施方案中,本发明涉及在患者或对象中治疗疼痛的方法,其包括施用包含本文中公开的阿片样镇痛剂的固体控制释放剂型。 [0038] In certain embodiments, the present invention relates to a method of treating pain in a patient or a subject, comprising administering a solid comprising an opioid analgesic disclosed herein, controlled release dosage form.

[0039] 在一些优选的实施方案中,本发明涉及在向患者或对象施用之后展现出基本零级释放速率的本发明剂型。 [0039] In some preferred embodiments, the present invention relates to exhibit substantially zero order release rate after administration of the dosage form to a patient or subject of the present invention.

[0040] 术语"零级释放速率"指来自剂型之活性剂释放的速率,其不依赖于在所述剂型中的剩余活性剂浓度,使得所述速率在一段时间中相对恒定。 [0040] The term "zero order release rate" refers to the rate of release of an active agent from the dosage form, which is not dependent on the residual concentration of active agent in the dosage form such that the rate is relatively constant over time. 展现零级释放速率的剂型在释放活性剂百分比对时间的图示中展现出相对直的线。 Show zero-order release dosage forms release rate of the active agent percentage in the illustrated time exhibit a relatively straight line. 在本发明的某些实施方案中,将基本零级释放定义为这样的剂型,如通过在USP装置1 (篮)中以IOOrpm在37°C下于900ml不含酶的模拟胃液(SGF)中体外溶出所测量的,所述剂型具有的所释放活性剂的量在8至24 小时或4至12小时与经过时间在20%内成比例。 In certain embodiments of the invention, a substantially zero order release is defined as a dosage form such as by 1 (basket) to the USP apparatus IOOrpm 37 ° C for 900ml simulated gastric fluid without enzymes (SGF) vitro dissolution measured, the dosage form having an amount of active agent released in 8-24 hours or 4-12 hours elapsed time and within 20% in proportion. 例如,体外在8小时时从剂型释放20% 的量和在24小时时释放60 (± 12) %的量字面上满足8至24小时与经过时间在20%内成比例的定义。 For example, in vitro release at 8 hours 20% of the amount released from the dosage form and the amount (± 12)% at 24 hours of 60 literally meet 8-24 hours elapsed time and the defined proportion of 20%. 这已经通过后者经过时间(24小时)和后者释放(60% )是前者时间(8小时)和前者释放(20% )的相同倍数(3)而证明。 This latter has passed the elapsed time (24 hours) and releases the latter (60%) the same multiple of the former time (8 hours) and releases the former (20%) (3) proof. 为了满足在8至24小时(或任何其他时间段)与经过时间在20%内成比例的定义,仅需要考虑数值的端点,但是该定义不排除端点内的其他时间点也可以是成比例的。 In order to meet the 8 to 24 hours (or any other period of time) and the elapsed time is within 20% in proportion to the definition, only necessary to consider the value of the end point, but this definition does not exclude other time points within an endpoint may be proportional .

[0041] 在本发明的另一些实施方案中,将基本零级释放定义为这样的剂型,其中,如通过在USP装置1(篮)中以IOOrpm在37°C下于900ml不含酶的模拟胃液(SGF)中体外溶出所测量的,在2小时时释放的活性剂的量为小于约25% ;在4小时时从所述剂型释放的活性剂的量为约10%至约30% ;在8小时时从所述剂型释放的活性剂的量为约20%至约60% ; 在12小时时从所述剂型释放的活性剂的量为约40%至约90%;并且在18小时时从所述剂型释放的活性剂的量为大于约70%。 [0041] In other embodiments of the present invention, a substantially zero order release is defined as a dosage form, wherein, as measured by the USP Apparatus 1 (basket) at IOOrpm at 37 ° C for simulation to 900ml without enzymes gastric fluid (SGF) as measured in vitro dissolution, the amount released at 2 hours active agent is less than about 25%; 4 hours the amount of released active agent from the dosage form from about 10% to about 30%; at 8 hours from the dosage form releases an amount of active agent is from about 20% to about 60%; at 12 hours the amount of release of active agent from the dosage form is from about 40% to about 90%; and 18 hours when the dosage form is released from an amount of active agent is greater than about 70%.

[0042] 对于本发明的目的而言,将术语"聚环氧乙烷"定义为分子量为至少25, 000(如本领域中常规测量的)(并且优选分子量为至少1〇〇, 〇〇〇)的聚环氧乙烷(polyethylene oxide,ΡΕ0)的组合物。 [0042] For the purposes of the present invention, the term "polyethylene oxide" is defined as a molecular weight of at least 25, 000 (as measured in conventional in the art) (and preferably a molecular weight of at least 1〇〇, 〇〇〇 ) polyethylene oxide (polyethylene oxide, ΡΕ0) composition. 一般将具有较低分子量的组合物称作聚乙二醇。 The composition will generally have a lower molecular weight polyethylene glycol is referred to.

[0043] 对于本发明的目的而言,基于流变学测量,将术语"高分子量聚环氧乙烷(PEO) "定义为近似分子量为至少1,〇〇〇, 000。 [0043] For the purposes of the present invention, based on rheological measurements, the term "high molecular weight polyethylene oxide (the PEO)" is defined as an approximate molecular weight of at least 1, 〇〇〇, 000.

[0044] 对于本发明的目的而言,基于流变学测量,将术语"低分子量聚环氧乙烷(PEO) "定义为近似分子量为低于1,〇〇〇, 000。 [0044] For the purposes of the present invention, based on rheological measurements, the term "low molecular weight polyethylene oxide (the PEO)" is defined as the approximate molecular weight of less than 1, 〇〇〇, 000.

[0045] 对于本发明的目的而言,将术语"直接压制"定义为指这样的方法,其中通过包括将成分共混并将共混物压制形成剂型之步骤的方法(例如通过利用扩散共混和/或对流混合法)来制备剂型(例如Guidance for Industry,SUPAC_IR/MR:Immediate Release and Modified Release Solid Oral Dosage Forms,Manufacturing Equipment Addendum)〇 The method (e.g. by using a diffusion blend and [0045] For the purposes of the present invention, the term "direct compression" is defined to mean a method which comprises blending the components by compressing the blend and the step of forming the dosage form of / or convection mixing process) of preparing dosage forms (e.g. Guidance for Industry, SUPAC_IR / MR: Immediate Release and Modified Release Solid Oral dosage Forms, Manufacturing Equipment Addendum) square

[0046] 在根据本发明的压扁剂型的上下文中使用的术语"压扁"或相关术语意指所述剂型经受当形状为除球形之外时从基本与所述剂型之最小直径(即,厚度)一致的方向上以及当所述剂型形状为球形时从任何方向上施加的力。 [0046] The terms used in the context of the present invention, the dosage form flattening the "flattening" or related term is meant when the dosage form is subjected to a spherical shape is other than the minimum diameter from the base of the dosage form (i.e., thickness) and force a uniform direction when the shape is spherical dosage form is applied from any direction.

[0047] 对于本发明某些实施方案的目的而言,将术语"抗压碎"定义为这样的剂型,其用本文中描述的台式压机(bench press)可至少被压扁而不破碎。 [0047] For the purposes of certain embodiments of the present invention, the term "resistant to crushing" is defined as a dosage form, bench press (bench press) which was described herein can at least be flattened without breaking.

[0048] 对于本发明的目的而言,术语"阿片样镇痛剂"意指选自以下的一种或更多种化合物:基础阿片样激动剂(base opioid agonist)、混合阿片样激动剂-诘抗剂、部分阿片样激动剂,其可药用盐、复合物、立体异构体、醚、酯、水合物和溶剂合物,及其混合物。 [0048] For the purposes of the present invention, the term "opioid analgesic" means selected from one or more of the compounds: the opioid agonist base (base opioid agonist), mixed opioid agonist - interrogate antagonist, partial agonist opioid, pharmaceutically acceptable salts, complexes, stereoisomers thereof, ethers, esters, hydrates and solvates thereof, and mixtures thereof.

[0049] 本文中使用的术语"模拟胃液"或"SGF"指在溶出测试中用于模仿胃的条件的水溶液(例如,〇· IN HCl的溶液)。 The term [0049] As used herein, 'simulated gastric fluid' or 'the SGF "refers to an aqueous solution used to mimic the dissolution test in gastric conditions (e.g., square · IN HCl solution).

[0050] 在例如"在0. 5小时时从被压扁剂型释放的活性剂的量与未被压扁剂型相比偏差不超过约20%点"的上下文中的术语"百分点"意指在压扁前之释放%与压扁后之释放% 的差异不超过20 ( 即,20或更少)。 [0050] In the context of, for example, "at 0.5 hours from the dosage form releases the active agent flattening amount dosage compared to the non flattening deviation of less than about 20% points" in the term "percent" means before the release and after the release of compressed% difference of not more than 20% by collapsing (i.e., 20 or less). 例如,来自被压扁剂型的60 %释放不超过来自未被压扁剂型的40 %释放的约20 %点。 For example, from a flattened dosage form releases not more than about 60% 20% 40% point of release from the dosage form has not been flattened.

[0051] 与"百分率(或% )点"无关的术语"百分数"或使用"%"是通常意义的百分比。 [0051] and "percent (or%) of the" irrelevant term "percent" or "%" is the percentage of the usual sense. 例如,48%释放在60%释放的20%内,而40%在字面上可能不在60%释放的20%内。 For example, 48% is released within 20% to 60% release, while 40% may not literally 20% 60% release.

[0052] 术语"患者"意指这样的对象(优选地为人),其已经呈现出建议需要治疗的特定症状的临床表现,对所述对象预防性地或预防地治疗病症,或者所述对象被诊断为患有待治疗的病症。 [0052] The term "patient" means a subject (preferably a human), which has shown clinical manifestations specific recommendations to be treated of the symptoms, the subject prophylactically treat or prevent a disorder, or the object is diagnosis of disease infestation to be treated.

[0053] 术语"对象"包括术语"患者"的定义并且包括术语"健康对象"(即,个体(例如, 人)),所述健康对象在所有方面中或对于特定病症而言是完全正常的。 [0053] The term "subject" includes a definition of the term "patient" and includes the term "healthy subject" (i.e., the individual (e.g., human)), the healthy subjects or in all respects is completely normal in terms for a particular condition .

[0054] 本文中使用的术语"立体异构体"是对仅原子空间定位不同的单个分子的所有异构体的通称。 [0054] The term used herein "stereoisomers" is positioned just atoms in space different term for all isomers of individual molecules. 它包括对映体和具有多于一个手性中心的彼此不成镜像的化合物的异构体(非对映体)。 It comprises (diastereomers) enantiomers and isomers of compounds with each other are not mirror images of more than one chiral center has.

[0055] 术语"手性中心"指与四个不同基团相连的碳原子。 [0055] The term "chiral center" refers to a carbon atom to which four different groups are attached.

[0056] 术语"对映体"或"对映体的"指其镜像不可重叠并且因此具有光学活性的分子, 其中对映体使偏振光平面向一个方向偏转,而其镜像则使偏振光平面向相反的方向偏转。 [0056] The term "enantiomer" or "enantiomeric" refers to its mirror image molecule can not overlap and thus have an optically active wherein the enantiomer deflecting plane of polarized light in one direction and its mirror image of the plane of polarized light deflected in the opposite direction.

[0057] 术语"外消旋"指对映体的混合物。 [0057] The term "racemic" refers to a mixture of enantiomers.

[0058] 术语"拆分"指分子之两个对映体形式中的一个的分离或浓缩或消耗。 [0058] The term "split" refers to a molecule of two enantiomeric forms of a separation or concentration or depletion.

[0059] 对于本发明的目的而言,将"氢可酮"定义为包括氢可酮游离碱,以及其可药用盐、 复合物、立体异构体、醚、酯、水合物和溶剂合物,及其混合物。 [0059] For the purposes of the present invention, the "Hydrocodone" is defined as including hydrocodone free base and pharmaceutically acceptable salts, complexes, stereoisomers thereof, ethers, esters, hydrates and solvates , and mixtures thereof.

[0060] 术语"USP桨法或篮法"是例如在US Pharmacopoeia XII (1990)中描述的桨法和篮法。 [0060] The term "or the USP Paddle Method Basket Method" is the Paddle and Basket Method methods such as described in US Pharmacopoeia XII (1990) in.

[0061] 对于本发明的目的而言,将术语"pH依赖性"定义为具有根据环境pH而变化的特征(例如,溶出)。 [0061] For the purposes of the present invention, the term "pH-dependent" is defined as having characteristics vary according to environmental pH (e.g., dissolution).

[0062] 对于本发明的目的而言,将术语"pH独立性"定义为具有基本不受pH影响的特征(例如,溶出)。 [0062] For the purposes of the present invention, the term "pH independent" is defined as having a characteristic substantially regardless of the pH (e.g., dissolution).

[0063] 对于本发明的目的而言,将术语"生物利用度"定义为从单位剂型吸收药物(例如,氢可酮)的相关程度。 [0063] For the purposes of the present invention, the term "bioavailability" is defined as the absorption of the drug from the dosage unit (e.g., hydrocodone) the degree of correlation. 也将生物利用度称为AUC(即,血浆浓度/时间曲线下面积)。 Also called bioavailability AUC (i.e., plasma concentration / time area under the curve). [0064] 对于本发明的目的而言,术语"控制释放"、"延长释放"或"持续释放"可互换并将其定义为以这样的速率释放药物(例如,氢可酮):在至少约12小时或更长或者至少24小时或更长的一段时间中使血液(例如,血浆)浓度维持在治疗范围内但是低于毒性浓度。 [0064] For the purposes of the present invention, the term "controlled release", "prolonged release" or "sustained release" are used interchangeably and defined as the release of the drug at such a rate (e.g., hydrocodone): at least about 12 hours or more, or at least 24 hours or longer period of time manipulation of the blood (e.g., plasma) concentration is maintained within the therapeutic range but below toxic concentrations. 优选地,控制释放剂型可提供每天一次或每天两次给药。 Preferably, the controlled release dosage form once or twice daily may be provided daily.

[0065] 术语" Cmax "表示在给药间隔期间获得的最大血浆浓度。 [0065] The term "Cmax" denotes the maximum plasma concentration obtained during the dosing interval.

[0066] 本文中使用的术语"C24"是在施用后24小时时药物的血浆浓度。 [0066] The term used herein, "C24" is the plasma concentration of the drug at 24 hours after administration.

[0067] 术语"Tmax"表示达到最大血浆浓度(Cmax)的时间。 [0067] The term "Tmax" denotes the maximum plasma concentration (Cmax) of time.

[0068] 对于本发明的目的而言,将术语"C24/Cmax比率"定义为在施用后24小时时药物的血浆浓度与在给药间隔内达到的药物最高血浆浓度的比率。 [0068] For the purposes of the present invention, the term "C24 / Cmax ratio" is defined as the ratio of the drug concentration in plasma and the highest plasma concentration within the dosing interval of the drug reaches at 24 hours after administration.

[0069] 术语"Tlag "表示在紧邻首次可测量的血浆浓度之前的时间点。 [0069] The term "Tlag" indicates a time point immediately before the first measurable plasma concentration.

[0070] 术语"T1/2 "表示终末相的血浆半衰期。 [0070] The term "T1 / 2" represents the terminal phase plasma half-life. 这是对于终末相中任何浓度降低一半所花费的时间。 This is the terminal phase for any concentration decreased the time it takes for half. 对于阿片样物质(例如氢可酮)的浓度,术语"最小有效镇痛浓度(minimum effective analgesic concentration)"或"MEAC"非常难以定量。 For opioid (e.g., hydrocodone) concentrations, the term "minimum effective analgesic concentration (minimum effective analgesic concentration)" or "MEAC" it is very difficult to quantify. 然而,通常存在血衆氢可酮的最小有效镇痛浓度,低于该浓度则不提供镇痛。 Typically, however, the presence of all the minimum effective analgesic hydrocodone serum concentration below which the concentration is not provided analgesia. 然而,例如血浆氢可酮水平与镇痛之间有间接关系,而较高和延长的血浆水平通常与优秀的疼痛缓解相关。 However, there is an indirect relationship between the plasma hydrocodone levels and analgesia, for example, the higher and prolonged plasma levels are generally associated with superior pain relief. 峰血浆氢可酮水平的时间与峰药物作用的时间之间有延迟(或滞后)。 Peak plasma hydrocodone levels between the peak time of drug action and the time delay (or lag). 通常,这适用于采用阿片样镇痛剂治疗疼痛。 Typically, this applies to the use of opioid analgesics for the treatment of pain.

[0071] 对于本发明的目的而言,除非另有详细指明,否则术语"患者"或"对象"意指讨论(或权利要求)涉及个体患者或对象的药物代谢动力学参数。 [0071] For the purposes of the present invention, unless otherwise specified in detail, otherwise, the term "patient" or "subject" is meant discussion relates pharmacokinetic parameters of an individual patient or subject (or claim).

[0072] 术语"患者群体"或"对象群体"或"健康对象群体"意指讨论(或权利要求)涉及至少两位患者、对象或健康对象,至少六位患者、对象或健康对象,或者至少十二位患者、对象或健康对象的平均药物代谢动力学参数。 [0072] The term "population of patients" or "subject groups" or "healthy subject group" means a discussion (or claim) relates to at least two patients, healthy subjects or objects, at least six patients, healthy subjects or objects, or at least twelve patients, average drug metabolism healthy subjects or objects of kinetic parameters.

[0073] 对于本发明的目的而言,本文中公开的控制释放制剂优选地是与剂量成比例的。 [0073] For the purposes of the present invention, disclosed herein are controlled release formulations are preferably dose proportional. 在与剂量成比例的制剂中,药物代谢动力学参数(例如,AUC和Cmax)和/或体外释放从一个剂量强度线性地提高至另一个。 In the dose-proportional formulation, the metabolism pharmacokinetic parameters (e.g., the AUC and Cmax) and / or to improve the in vitro release linearly from one dosage strength to another. 因此,可从同一制剂的不同剂量的参数中推断特定剂量的药物代谢动力学参数和体外参数。 Therefore, pharmacokinetic parameters can be inferred and the in vitro specific dose parameters from the parameter different doses of the same formulation.

[0074] 术语"首次施用"意指在向个体对象、患者或健康对象或者对象群体、患者群体或健康对象群体开始治疗时的本发明的单一剂量。 [0074] The term "first administration" means a single dose of the present invention, when the individual subject, patient or healthy subject or subject population, patient population or population of healthy subjects began treatment.

[0075] 术语"稳态"意指药物到达系统的量与药物离开系统的量大致相同。 [0075] The term "steady state" is meant an amount of the drug reaching the system and the amount of the drug leaving the system is substantially the same. 因此,在"稳态"时,患者的机体以药物通过吸收到血流中而成为对患者之系统可用的近似相同速率消除药物。 Thus, when the "steady state", the patient's body through the drug to be absorbed into the bloodstream to be approximately the same rate as the system of the patient to eliminate the available drugs.

附图说明 BRIEF DESCRIPTION

[0076] 图1是描述实施例1~4的组合物之溶出的图。 [0076] FIG. 1 is a graph depicting the dissolution of the composition of Examples 1 to 4 embodiment.

[0077] 图2是描述实施例5和6的组合物之溶出的图。 [0077] FIG. 2 is a graph depicting the dissolution of the compositions of Examples 5 and 6 embodiment.

[0078] 图3是描述实施例7~12的组合物之溶出的图。 [0078] FIG. 3 is a graph depicting the dissolution of the compositions of Examples 7 to 12 embodiment.

[0079] 图4是描述实施例13迭代(Iteration) 1之平均血浆浓度时间曲线的图。 [0079] FIG. 4 is described in Example 13 iterations (the Iteration) of the mean plasma concentration time curve of FIG. 1 embodiment.

[0080] 图5是描述实施例13迭代2之平均血浆浓度时间曲线的图。 [0080] FIG. 5 is a description of FIG. 13 iterations mean plasma concentration time curve 2 embodiment.

[0081] 图6是描述实施例13迭代3之平均血浆浓度时间曲线的图。 [0081] FIG 6 is described with FIG. 13 iterations of the mean plasma concentration-time curve of Example 3.

[0082] 图7是描述实施例14~20的组合物之血浆浓度的图。 [0082] Figure 7 is a plasma concentration of the composition of Examples 14 to 20. FIG embodiment.

具体实施方式 Detailed ways

[0083] 本发明涉及控制释放药物制剂,在某些实施方案中,与外部区域相比,所述制剂在剂型的内部区域包含更高浓度的药物。 [0083] The present invention relates to controlled release pharmaceutical formulation, in certain embodiments, as compared to the outer region, the inner region of the dosage form in a pharmaceutical formulation containing a higher concentration. 优选地,将内部区域和外部区域配置成内部核心(例如,压制片)和包覆所述核心的壳(例如,压制包衣)。 Preferably, the inner and outer core region configured as an internal (e.g., compressed tablets) and a shell covering the core (e.g., press-coating). 活性剂可仅包含在核心中或均包含在核心和壳二者中。 It may contain only the active agent in the core or are contained in both the core and shell. 在一些优选的实施方案中,活性剂从剂型的释放基本是零级,这与一些替代治疗(例如,立即释放剂型)相比提供了给药确定性和降低的血浆波动。 In some preferred embodiments, the active agent is released from the dosage form is substantially zero order, which compared to some alternative therapy (e.g., an immediate release dosage form) and provides certainty administration reduced plasma fluctuations.

[0084] 本发明的剂型优选地为抗篡改的,因它们难以压碎或研磨(例如,根据本文中公开的压扁标准)。 Dosage forms of the present invention is [0084] preferably tamper-resistant, because they are difficult to crush or grind (e.g., in accordance with standard compressed disclosed herein). 该特征使得它们尤其适合用于控制释放阿片样镇痛剂产品,其具有旨在经一段时间从每个剂量单位释放的大剂量阿片样镇痛剂。 This feature makes them particularly suitable for controlled release opioid analgesic products, which have a large dose of opioid analgesic released is intended a period of time from each dosage unit. 药物滥用者通常可取得控制释放产品,并将所述产品压碎、剪切、研磨、咀嚼、溶出、加热、提取或以其他方式损坏,使得剂型的大部分或全部内含物变成可用于通过注射、吸入和/或口服消耗而立即吸收。 Drug abusers may generally obtain controlled release products, and the crushed product, shearing, grinding, chewing, dissolution, heating, extraction, or otherwise damaged, such that most or all of the dosage form become available for inclusion by injection, inhalation, and / or oral consumption immediately absorbed.

[0085] 本发明剂型的壳优选地难以与核心物理性地分开。 [0085] Preferably the dosage forms of the shell of the present invention is difficult to separate the core physically. 在与壳相比在核心中具有提高量之活性剂的实施方案中尤其有用,因为滥用者将难以获得核心的较大药物有效荷载。 In particularly useful embodiments, compared with the case of having to increase the amount of active agent in the core, it will be difficult due to abuse of the drug core of a larger payload. [0086] 在某些实施方案中,本发明涉及固体控制释放剂型,其包含:核心,所述核心包含分散在第一基质材料中的第一部分阿片样镇痛剂;和壳,所述壳包覆核心并且包含分散在第二基质材料中的第二部分阿片样镇痛剂。 [0086] In certain embodiments, the present invention relates to a solid controlled release dosage form comprising: a core, said core comprising a first portion opioid analgesic dispersed in a first matrix material; and a shell package a second portion covering the core and comprising an opioid analgesic dispersed in a second matrix material.

[0087] 可例如通过直接压制、挤出或模制(molding)来形成剂型的核心。 [0087] for example, by direct compression, extrusion or molding (Molding) forming a dosage form core. 优选地,内部核心提供了控制释放赋形剂并且是压制片剂的形式。 Preferably, the inner core and provide a controlled release excipient is in the form of compressed tablets.

[0088] 可例如通过压制包衣、模制、将一个或更多个层喷涂在核心上、将一个或更多个层浸渍在核心上或者其组合来形成剂型的壳。 [0088] The coating may be, for example, by compression molding, one or more coating layers on the core, one or more layers on the core is impregnated, or a combination dosage form of a shell. 优选地,壳包含控制释放赋形剂并且是压制包衣。 Preferably, the controlled release excipient comprising a shell and a compression coating.

[0089] 在一些优选的实施方案中,本文中描述的剂型的核心与壳的重量比为约1 : 0. 5 至约1 : 5;约1 : 0. 5至约1 : 2;约1 : 0. 6至约1 : 1.5;或约1 : 0. 8至约1 : 1.2。 [0089] In some preferred embodiments, the weight of the core and the shell of the dosage form described herein is from about 1: 0.5 to about 1: 5; about 1: 0.5 to about 1: 2; about 1 : 0.6 to about 1: 1.5; or from about 1: 0.8 to about 1: 1.2.

[0090] 在一些优选的实施方案中,核心和壳在视觉上不可区分(例如,通过颜色)并且每种组分之间没有清楚的界限。 [0090] In some preferred embodiments, the core and the shell can not be visually distinguished (e.g., by a color) and there is no clear distinction between each component. 这通过阻碍获得核心的努力而有助于剂型的抗篡改,在某些实施方案中,所述核心将包含大多数活性剂。 This is accomplished by hindering efforts to obtain the core of the dosage form and contribute to the tamper resistance, in certain embodiments, the core will contain most of the active agent. 为了评价壳和核心的颜色,可使用的一种测量是CIE L * A * B *值。 To evaluate the color of the core and the shell, it may be used for measuring the CIE L * A * B * values. 优选地,核心和壳的CIE L * A * B *值在彼此的10%之内。 Preferably, the core and the shell of the CIE L * A * B * values ​​within 10% of each other. 用于评价颜色的另一种测量是使用RYB或RGB色轮(color wheel),其中核心和壳优选地对应于同一色调或临近色调。 Another measure is to use for evaluating color RYB or RGB color wheel (color wheel), wherein the core and the shell preferably corresponds to or near the same tone color tone.

[0091] 在某些实施方案中,第一基质材料包含ΡΕ0。 [0091] In certain embodiments, the first matrix material comprises ΡΕ0. 在另一些实施方案中,第二基质材料包含ΡΕ0。 In other embodiments, the second matrix material comprises ΡΕ0. 在另一些实施方案中,第一基质材料包含PEO并且第二基质材料包含ΡΕ0。 In other embodiments, the matrix material comprises a first and a second matrix material comprises PEO ΡΕ0. 优选地,聚环氧乙烷均包含在两种组分中。 Preferably, the polyethylene oxide are contained in both components. 在这样的一些实施方案中,第一基质材料中PEO的分子量与第二基质材料中的平均分子量相同或不同。 In some such embodiments, the first matrix material, the molecular weight of PEO in the second matrix material is the same or different average molecular weights. 在某些实施方案中,在两种组分中均包含的PEO的分子量在彼此的20%内、10%内或5%内。 In certain embodiments, the molecular weight of PEO in both components are contained within 20% of each other, within 10% or within 5%.

[0092] 在本发明的一些优选的实施方案中,当在第一和第二基质二者中均存在聚环氧乙烷时,在第一基质中(在核心中)使用的聚环氧乙烷的分子量低于在第二基质材料中(在壳中)使用的聚环氧乙烷的分子量。 [0092] In some preferred embodiments of the present invention, when a polyethylene oxide are present in both the first and second matrix, the first matrix (the core) of the poly ethylene alkoxy of molecular weight below the molecular weight of polyethylene oxide (in shell) used in the second matrix material. 例如,在一些优选的实施方案中,第一基质材料中的聚环氧乙烷可具有约300, 000至约10, 000, 000的分子量并且第二基质材料中的聚环氧乙烷可具有约1,〇〇〇, 000至约10, 〇〇〇, 000的分子量。 For example, in some preferred embodiments, the first matrix material can be polyethylene oxide having about 300, about 000 to 10, 000, 000 and the molecular weight of the second matrix material may have a polyethylene oxide about 1, 〇〇〇, about 10 to 000, 〇〇〇 molecular weight of 000. 在另一些优选的实施方案中,第一基质材料中的聚环氧乙烷可具有约300, OOO至约3, 000, OOO的分子量并且第二基质材料中的聚环氧乙烷可具有约4, 000, 000至约10, 000, 000的分子量。 In other preferred embodiments, the first matrix material can be polyethylene oxide having about 300, OOO to about 3, 000, OOO molecular weight and a second matrix material may have a polyethylene oxide of about 4, 000, 000 to about 10, 000, 000 molecular weight. 在另一些优选的实施方案中,第一基质材料中的聚环氧乙烷可具有约500, 000至约1,000, 000的分子量并且第二基质材料中的聚环氧乙烷可具有约6, 000, 000至约8, 000, 000的分子量。 In other preferred embodiments, the first matrix material can be polyethylene oxide having about 500, 000 to about 1,000, 000 molecular weight and a second matrix material may have a polyethylene oxide of about 6, 000, 000 to about 8,000, 000 molecular weight.

[0093] 在某些实施方案中,第一部分中(核心中)的活性剂(例如,阿片样镇痛剂)与第二部分中(壳中)的活性剂相同。 [0093] In certain embodiments, the first portion (core) of the active agent (e.g., opioid analgesic) and a second portion (shell) of the same active agent. 在另一些实施方案中,第一部分中的活性剂与第二部分中的活性剂不同。 In other embodiments, the active agent in the first portion and the second portion of the different active agents.

[0094] 在某些实施方案中,在核心中活性剂(例如,阿片样镇痛剂)与在壳中活性剂的比率为约I : 1至约10 : 1;约2 : 1至约8 : 1;约2 : 1至约5 : 1或约4 : 1。 [0094] In certain embodiments, the ratio of the core active agent (e.g., opioid analgesic) and in the shell about the I active agent: 1 to about 10: 1; from about 2: 1 to about 8 : 1; from about 2: 1 to about 5: 1 or about 4: 1.

[0095] 在某些实施方案中,在第一基质材料中第一部分活性剂(例如,阿片样镇痛剂)与聚环氧乙烷的重量比为约1 : 0.25至约1 : 30;约1 : 0.5至约1 : 100;约1 : 0.5至约1 : 20 ;约I : 1 至约I : 10 ;约1 : 15 至约1 : 20 ;约I : 1. 5 至约1 : 4 ;约1 : 18 或约1 : 2。 [0095] In certain embodiments, the first matrix material by weight of the first portion of active agent (e.g., opioid analgesic) to polyethylene oxide ratio of about 1: 0.25 to about 1:30; about 1: 0.5 to about 1: 100; from about 1: 0.5 to about 1:20; about the I: 1 to about I: 10; from about 1:15 to about 1:20; about I: 1. 5 to about 1: 4 ; from about 1: 18 or about 1: 2.

[0096] 在一些替代实施方案中,在第二基质材料中第二部分活性剂(例如,阿片样镇痛剂)与聚环氧乙烷的重量比为约I : 1至约1 : 200 ;约I : 1至约1 : 125 ;约1 : 2至约1 : 100 ;约1 : 5 至约1 : 50 ;约1 : 12 至约1 : 25 ;约1 : 98 或约1 : 15。 [0096] In alternative embodiments, the second matrix material by weight of the second portion of the active agent (e.g., opioid analgesic) and polyethylene oxide is about the I: 1 to about 1: 200; about the I: 1 to about 1: 125; from about 1: 2 to about 1: 100; from about 1: 5 to about 1:50; about 1: 12 to about 1:25; about 1: 98 or about 1:15.

[0097] 在某些实施方案中,如通过在USP装置1(篮)中以IOOrpm在37 °C下于900ml不含酶的模拟胃液(SGF)中体外溶出所测量的,从剂型释放的活性剂(例如,阿片样镇痛剂) 的量在8至24小时与经过时间在20%内、或10%内、或5%内成比例。 [0097] In certain embodiments, such as by the USP Apparatus 1 (basket) at IOOrpm at 37 ° C for 900ml simulated gastric fluid without enzymes (SGF) as measured in vitro dissolution, release of the active from the dosage form the amount of agent (e.g., opioid analgesic) is from 8 to 24 hours elapsed time and within 20%, or 10%, or 5% by proportional.

[0098] 在某些实施方案中,如通过在USP装置1(篮)中以IOOrpm在37 °C下于900ml不含酶的模拟胃液(SGF)中体外溶出所测量的,从剂型释放的活性剂(例如,阿片样镇痛剂) 的量在8至18小时与经过时间在20%内、或10%内、或5%内成比例。 [0098] In certain embodiments, such as by the USP Apparatus 1 (basket) at IOOrpm at 37 ° C for 900ml simulated gastric fluid without enzymes (SGF) as measured in vitro dissolution, release of the active from the dosage form the amount of agent (e.g., opioid analgesic) at 8 to 18 hours elapsed time and within 20%, or 10%, or 5% by proportional.

[0099] 在某些实施方案中,如通过在USP装置1(篮)中以IOOrpm在37 °C下于900ml不含酶的模拟胃液(SGF)中体外溶出所测量的,从剂型释放的活性剂(例如,阿片样镇痛剂) 的量在8至12小时与经过时间在20%内、或10%内、或5%内成比例。 [0099] In certain embodiments, such as by the USP Apparatus 1 (basket) at IOOrpm at 37 ° C for 900ml simulated gastric fluid without enzymes (SGF) as measured in vitro dissolution, release of the active from the dosage form the amount of agent (e.g., opioid analgesic) at 8 to 12 hours and the elapsed time to within 20%, or 10%, or the proportion of 5%.

[0100] 在某些实施方案中,如通过在USP装置1(篮)中以IOOrpm在37 °C下于900ml不含酶的模拟胃液(SGF)中体外溶出所测量的,从剂型释放的活性剂(例如,阿片样镇痛剂) 的量在12至24小时与经过时间在20%内、或10%内、或5%内成比例。 [0100] In certain embodiments, such as by the USP Apparatus 1 (basket) at IOOrpm at 37 ° C for 900ml simulated gastric fluid without enzymes (SGF) as measured in vitro dissolution, release of the active from the dosage form the amount of agent (e.g., opioid analgesic) at 12 to 24 hours elapsed time and within 20%, or 10%, or 5% by proportional.

[0101] 在某些实施方案中,如通过在USP装置1(篮)中以IOOrpm在37°C下于900ml不含酶的模拟胃液(SGF)中体外溶出所测量的,从剂型释放的活性剂(例如,阿片样镇痛剂) 的量在12至18小时与经过时间在20%内、或10%内、或5%内成比例。 [0101] In certain embodiments, such as by the USP Apparatus 1 (basket) at IOOrpm at 37 ° C for 900ml simulated gastric fluid without enzymes (SGF) as measured in vitro dissolution, release of the active from the dosage form the amount of agent (e.g., opioid analgesic) at 12 to 18 hours elapsed time and within 20%, or 10%, or 5% by proportional.

[0102] 在某些实施方案中,如通过在USP装置1(篮)中以IOOrpm在37 °C下于900ml不含酶的模拟胃液(SGF)中体外溶出所测量的,从剂型释放的活性剂(例如,阿片样镇痛剂) 的量在4至20小时与经过时间在20%内、或10%内、或5%内成比例。 [0102] In certain embodiments, such as by the USP Apparatus 1 (basket) at IOOrpm at 37 ° C for 900ml simulated gastric fluid without enzymes (SGF) as measured in vitro dissolution, release of the active from the dosage form the amount of agent (e.g., opioid analgesic) at 4-20 hours and elapsed time to within 20%, or 10%, or the proportion of 5%.

[0103] 在某些实施方案中,如通过在USP装置1(篮)中以IOOrpm在37 °C下于900ml不含酶的模拟胃液(SGF)中体外溶出所测量的,从剂型释放的活性剂(例如,阿片样镇痛剂) 的量在4至15小时与经过时间在20%内、或10%内、或5%内成比例。 [0103] In certain embodiments, such as by the USP Apparatus 1 (basket) at IOOrpm at 37 ° C for 900ml simulated gastric fluid without enzymes (SGF) as measured in vitro dissolution, release of the active from the dosage form the amount of agent (e.g., opioid analgesic) is 4-15 hours are proportional to the elapsed time within 20%, or 10%, or 5%.

[0104] 在某些实施方案中,如通过在USP装置1(篮)中以IOOrpm在37 °C下于900ml不含酶的模拟胃液(SGF)中体外溶出所测量的,从剂型释放的活性剂(例如,阿片样镇痛剂) 的量在4至10小时与经过时间在20%内、或10%内、或5%内成比例。 [0104] In certain embodiments, such as by the USP Apparatus 1 (basket) at IOOrpm at 37 ° C for 900ml simulated gastric fluid without enzymes (SGF) as measured in vitro dissolution, release of the active from the dosage form the amount of agent (e.g., opioid analgesic) at 4 to 10 hours elapsed time and within 20%, or 10%, or 5% by proportional.

[0105] 在某些实施方案中,如通过在USP装置1(篮)中以IOOrpm在37 °C下于900ml不含酶的模拟胃液(SGF)中体外溶出所测量的,从剂型释放的活性剂(例如,阿片样镇痛剂) 的量在8至20小时与经过时间在20%内、或10%内、或5%内成比例。 [0105] In certain embodiments, such as by the USP Apparatus 1 (basket) at IOOrpm at 37 ° C for 900ml simulated gastric fluid without enzymes (SGF) as measured in vitro dissolution, release of the active from the dosage form the amount of agent (e.g., opioid analgesic) at 8 to 20 hours elapsed time and within 20%, or 10%, or 5% by proportional.

[0106] 在某些实施方案中,如通过在USP装置1(篮)中以IOOrpm在37 °C下于900ml不含酶的模拟胃液(SGF)中体外溶出所测量的,从剂型释放的活性剂(例如,阿片样镇痛剂) 的量在10至15小时与经过时间在20%内、或10%内、或5%内成比例。 [0106] In certain embodiments, such as by the USP Apparatus 1 (basket) at IOOrpm at 37 ° C for 900ml simulated gastric fluid without enzymes (SGF) as measured in vitro dissolution, release of the active from the dosage form the amount of agent (e.g., opioid analgesic) at 10 to 15 hours elapsed time to within 20%, or 10%, or the proportion of 5%.

[0107] 在某些实施方案中,如通过在USP装置1(篮)中以IOOrpm在37 °C下于900ml不含酶的模拟胃液(SGF)中体外溶出所测量的,在2小时时释放的活性剂(例如,阿片样镇痛剂)的量小于约25% ;在4小时时从剂型释放的活性剂的量为约10%至约30% ;在8小时时从剂型释放的活性剂的量为约20%至约60% ;在12小时时从剂型释放的活性剂的量为约40%至约90% ;并且在18小时时从剂型释放的活性剂的量大于约70%。 [0107] In certain embodiments, such as by the USP Apparatus 1 (basket) at IOOrpm at 37 ° C for 900ml simulated gastric fluid without enzymes (SGF) as measured in vitro dissolution release at 2 hours amount of the active agent (e.g., opioid analgesic) is less than about 25%; 4 hours the amount of release of active agent from the dosage form from about 10% to about 30%; at 8 hours from the dosage form releases the active agent in an amount of from about 20% to about 60%; an amount at 12 hours released from the dosage form of active agent is from about 40% to about 90%; amount and at 18 hours released from the dosage form of active agent than about 70%.

[0108] 在某些实施方案中,如通过在USP装置1(篮)中以IOOrpm在37 °C下于900ml不含酶的模拟胃液(SGF)中体外溶出所测量的,在2小时时释放的活性剂(例如,阿片样镇痛剂)的量小于约15% ;在4小时时从剂型释放的活性剂的量为约10%至约20% ;在8小时时从剂型释放的活性剂的量为约30%至约45% ;在12小时时从剂型释放的活性剂的量为约50%至约70% ;并且在18小时时从剂型释放的活性剂的量大于约90%。 [0108] In certain embodiments, such as by the USP Apparatus 1 (basket) at IOOrpm at 37 ° C for 900ml simulated gastric fluid without enzymes (SGF) as measured in vitro dissolution release at 2 hours amount of the active agent (e.g., opioid analgesic) is less than about 15%; 4 hours the amount of release of active agent from the dosage form from about 10% to about 20%; at 8 hours from the dosage form releases the active agent in an amount of from about 30% to about 45%; an amount at 12 hours released from the dosage form of active agent is from about 50% to about 70%; amount and at 18 hours released from the dosage form of active agent than about 90%.

[0109] 在某些实施方案中,如通过在USP装置1(篮)中以IOOrpm在37 °C下于900ml不含酶的模拟胃液(SGF)中体外溶出所测量的,在2小时时释放的活性剂(例如,阿片样镇痛剂)的量小于约10% ;在4小时时从剂型释放的活性剂的量为约20%至约30% ;在8小时时从剂型释放的活性剂的量为约45%至约60% ;在12小时时从剂型释放的活性剂的量为约70%至约90% ;并且在18小时时从剂型释放的活性剂的量大于约95%。 [0109] In certain embodiments, such as by the USP Apparatus 1 (basket) at IOOrpm at 37 ° C for 900ml simulated gastric fluid without enzymes (SGF) as measured in vitro dissolution release at 2 hours amount of the active agent (e.g., opioid analgesic) is less than about 10%; 4 hours the amount of release of active agent from the dosage form is from about 20% to about 30%; at 8 hours from the dosage form releases the active agent in an amount of from about 45% to about 60%; an amount at 12 hours released from the dosage form of active agent is from about 70% to about 90%; amount and at 18 hours released from the dosage form of active agent than about 95%.

[0110] 在某些实施方案中,如通过在USP装置1(篮)中以IOOrpm在37 °C下于900ml不含酶的模拟胃液(SGF)中体外溶出所测量的,从剂型释放的活性剂(例如,阿片样镇痛剂) 的量在8至24小时与经过时间在20%内成比例,并且展现出以下中的至少一个:(i)在2 小时时所释放阿片样镇痛剂的量小于约20%,(ii)在4小时时所释放阿片样镇痛剂的量为约10%至约30%,(iii)在8小时时所释放阿片样镇痛剂的量为约30%至约60%,(iv)在12小时时所释放阿片样镇痛剂的量为约50%至约90%,或(V)在18小时时所释放阿片样镇痛剂的量大于约80%。 [0110] In certain embodiments, such as by the USP Apparatus 1 (basket) at IOOrpm at 37 ° C for 900ml simulated gastric fluid without enzymes (SGF) as measured in vitro dissolution, release of the active from the dosage form the amount of agent (e.g., opioid analgesic) at 8 to 24 hours elapsed time and within 20% proportional, and exhibits at least one of the following: (i) the released at 2 hours opioid analgesic the amount of opioid analgesic released at 8 hours is less than about 20%, (ii) the amount of opioid analgesic released at 4 hours from about 10% to about 30%, (iii) from about an amount of 30% to about 60%, (iv) opioid analgesic released at 12 hours from about 50% to about 90%, or (V) opioid analgesic released at 18 hours is greater than about 80%.

[0111] 在某些实施方案中,如通过在USP装置1(篮)中以IOOrpm在37 °C下于900ml不含酶的模拟胃液(SGF)中体外溶出所测量的,从剂型释放的活性剂(例如,阿片样镇痛剂) 的量在8至24小时与经过时间在20%内成比例,并且展现出以下中的至少一个:(i)在2 小时时所释放阿片样镇痛剂的量小于约15%,(ii)在4小时时所释放阿片样镇痛剂的量为约10%至约20%,(iii)在8小时时所释放阿片样镇痛剂的量为约30%至约45%,(iv)在12小时时所释放阿片样镇痛剂的量为约50%至约70%,或(V)在18小时时所释放阿片样镇痛剂的量大于约90%。 [0111] In certain embodiments, such as by the USP Apparatus 1 (basket) at IOOrpm at 37 ° C for 900ml simulated gastric fluid without enzymes (SGF) as measured in vitro dissolution, release of the active from the dosage form the amount of agent (e.g., opioid analgesic) at 8 to 24 hours elapsed time and within 20% proportional, and exhibits at least one of the following: (i) the released at 2 hours opioid analgesic the amount of opioid analgesic released at 8 hours is less than about 15%, (ii) the amount of opioid analgesic released at 4 hours from about 10% to about 20%, (iii) from about an amount of 30% to about 45%, (iv) opioid analgesic released at 12 hours from about 50% to about 70%, or (V) opioid analgesic released at 18 hours is greater than about 90%.

[0112] 在某些实施方案中,如通过在USP装置1(篮)中以IOOrpm在37 °C下于900ml不含酶的模拟胃液(SGF)中体外溶出所测量的,从剂型释放的活性剂(例如,阿片样镇痛剂) 的量在8至24小时与经过时间在20%内成比例,并且展现出以下中的至少一个:(i)在2 小时时所释放阿片样镇痛剂的量小于约10%,(ii)在4小时时所释放阿片样镇痛剂的量为约20%至约30%,(iii)在8小时时所释放阿片样镇痛剂的量为约45%至约60%,(iv)在12小时时所释放阿片样镇痛剂的量为约70%至约90%,或(V)在18小时时所释放阿片样镇痛剂的量大于约95%。 [0112] In certain embodiments, such as by the USP Apparatus 1 (basket) at IOOrpm at 37 ° C for 900ml simulated gastric fluid without enzymes (SGF) as measured in vitro dissolution, release of the active from the dosage form the amount of agent (e.g., opioid analgesic) at 8 to 24 hours elapsed time and within 20% proportional, and exhibits at least one of the following: (i) the released at 2 hours opioid analgesic the amount of opioid analgesic released at 8 hours is less than about 10%, (ii) the amount of opioid analgesic released at 4 hours is from about 20% to about 30%, (iii) from about an amount of 45% to about 60%, (iv) opioid analgesic released at 12 hours was about 70% to about 90%, or (V) opioid analgesic released at 18 hours is greater than about 95%.

[0113] 在某些实施方案中,如通过在USP装置1(篮)中以IOOrpm在37 °C下于900ml不含酶的模拟胃液(SGF)中体外溶出所测量的,从剂型释放的活性剂(例如,阿片样镇痛剂) 的量在8至24小时与经过时间在20%内成比例,并且展现出以下中的至少一个:(i)在2 小时时所释放阿片样镇痛剂的量小于约15%,(ii)在4小时时所释放阿片样镇痛剂的量为约8%至约20%,(iii)在8小时时所释放阿片样镇痛剂的量为约20%至约50%,(iv)在12小时时所释放阿片样镇痛剂的量为约40%至约70%,(V)在18小时时所释放阿片样镇痛剂的量大于约70%,或(vi)在24小时时从剂型释放的阿片样镇痛剂的量大于约90%。 [0113] In certain embodiments, such as by the USP Apparatus 1 (basket) at IOOrpm at 37 ° C for 900ml simulated gastric fluid without enzymes (SGF) as measured in vitro dissolution, release of the active from the dosage form the amount of agent (e.g., opioid analgesic) at 8 to 24 hours elapsed time and within 20% proportional, and exhibits at least one of the following: (i) the released at 2 hours opioid analgesic the amount of opioid analgesic released at 8 hours is less than about 15%, (ii) the amount of opioid analgesic released at 4 hours is from about 8% to about 20%, (iii) from about an amount of 20% to about 50%, (iv) opioid analgesic released at 12 hours about 40% to about 70%, (V) at 18 hours of the opioid analgesic released is greater than about 70%, or (vi) opioid analgesic released at 24 hours from the dosage form is greater than about 90%.

[0114] 剂型 [0114] formulations

[0115] 在某些实施方案中,可通过以下来制备核心,将控制释放材料、活性剂和任选地另一些赋形剂干共混,然后将混合物制粒直到获得适当的颗粒。 [0115] In certain embodiments, the core can be prepared by the controlled release material, dry blending the active agent and optionally other excipients, then granulating the mixture until the appropriate particle. 可通过干法制粒或湿法制粒方法进行该过程。 The process may be carried out by a dry granulation or a wet granulation process. 通常采用湿法制粒,将湿颗粒在流化床干燥器中干燥,然后筛分并研磨成适当大小。 Usually wet granulation, the wet granules in a fluid bed drier, sieved and then milled to the appropriate size. 通常将润滑剂与颗粒混合以得到最终核心制剂。 Typically the lubricant is mixed with the core particles to obtain the final formulation.

[0116] 可用于包含于根据本发明的制剂而选择的合适控制释放材料的非限制性列表包括亲水性和疏水性材料,例如缓释聚合物、树胶、丙烯酸树脂、蛋白质来源的材料、蜡、虫胶和油(例如氢化蓖麻油和氢化植物油)。 [0116] useful for inclusion in the non-limiting list of suitable controlled-release formulation of the material according to the present invention is selected include hydrophilic and hydrophobic materials, such as a slow release polymer materials, gums, acrylic resins, protein derived wax , shellac, and oils (e.g. hydrogenated castor oil and hydrogenated vegetable oil). 更具体地,控制释放材料可以是例如烷基纤维素如乙基纤维素、丙烯酸和甲基丙烯酸聚合物及共聚物,以及纤维素醚如羟烷基纤维素(例如, 羟丙基甲基纤维素)和羧烷基纤维素。 More specifically, the control release material may be, for example alkylcelluloses such as ethylcellulose, acrylic and methacrylic acid polymers and copolymers, and cellulose ethers such as hydroxyalkyl celluloses (e.g., hydroxypropyl methylcellulose hormone) and carboxyalkylcelluloses. 蜡包括例如天然和合成蜡、脂肪酸、脂肪醇及其混合物(例如,蜂蜡、巴西棕榈蜡、硬脂酸和硬脂醇)。 Include waxes such as natural and synthetic waxes, fatty acids, fatty alcohols and mixtures thereof (e.g., beeswax, carnauba wax, stearic acid and stearyl alcohol). 某些实施方案在核心的基质中使用两种或更多种前述控制释放材料的混合物。 Certain embodiments of the aforementioned mixture of two or more kinds of material in a controlled release matrix core. 然而,可根据本发明使用能够赋予活性剂之控制释放的任何可药用疏水性或亲水性控制释放材料。 However, it may be capable of imparting controlled release of the active agent can be any pharmaceutically acceptable hydrophobic or hydrophilic controlled-release material in accordance with the present invention.

[0117] 核心还可包含合适量的另外的赋形剂,例如,润滑油、黏合剂、制粒助剂、稀释剂、 着色剂、调味剂(例如,苦味剂)和助流剂,其在药学领域中均是常规的。 [0117] The core may further comprise a suitable amount of additional excipients, e.g., lubricants, binders, granulating aids, diluents, coloring agents, flavoring agents (e.g., a bittering agent) and a glidant, in which pharmaceutical field are conventional.

[0118] 在Handbook of Pharmaceutical Excipients, American Pharmaceutical Association (1986)中描述了可用于配制核心的可药用稀释剂和赋形剂的具体实例,其通过引用并入本文中。 [0118] of Pharmaceutical Excipients, American Pharmaceutical Association (1986) describes specific examples of a pharmaceutically acceptable diluent and excipients used in formulating the core Handbook, which is incorporated by reference herein.

[0119] 在一些优选的实施方案中,本发明剂型的基质合并了聚环氧乙烷(例如,高和/或低分子量ΡΕ0)。 [0119] In some preferred embodiments, the dosage form of the present invention incorporating a matrix of polyethylene oxide (e.g., high and / or low molecular weight ΡΕ0).

[0120] 当使用布氏黏度计(Brookfield viscometer)RVF 型和转子(spindle)No. 1 以IOrpm在25°C下测量的PEO的2% (按重量计)水溶液示出400至800mPa-s (cP)的黏度范围时,认为聚环氧乙烷具有1,〇〇〇, 〇〇〇的近似分子量。 [0120] When using a Brookfield viscometer (Brookfield viscometer) RVF type and a rotor (spindle) No. 1 to 2% IOrpm measured at 25 ° C PEO (by weight) aqueous solution shows 400 to 800mPa-s ( when cP) viscosity range, that has a polyethylene oxide, 〇〇〇, an approximate molecular weight of 〇〇〇.

[0121] 当使用布氏黏度计RVF型和转子No. 3以IOrpm在25°C下测量的PEO的2% (按重量计)水溶液示出2000至4000mPa-s (cP)的黏度范围时,认为聚环氧乙烷具有2, 000, 000 的近似分子量。 When [0121] When using a Brookfield RVF viscometer and a rotor No. 3 type to 2% IOrpm measured at 25 ° C PEO (by weight) aqueous solution to 2000 shown 4000mPa-s (cP) viscosity range, that polyethylene oxide having a 2,000, an approximate molecular weight of 000.

[0122] 当使用布氏黏度计RVF型和转子No.2以2rpm在25°C下测量的聚环氧乙烷的1% (按重量计)水溶液示出1650至5500mPa-s(cP)的黏度范围时,认为聚环氧乙烷具有4,000,000的近似分子量。 [0122] When using a Brookfield viscometer model RVF and No.2 rotor at 1% 2rpm measured at 25 ° C for the polyethylene oxide (by weight) aqueous solution to 1650 shown 5500mPa-s (cP) of when the viscosity range of polyethylene oxide having an approximate molecular weight of 4,000,000.

[0123] 当使用布氏黏度计RVF型和转子No.2以2rpm在25°C下测量的聚环氧乙烷的1% (按重量计)水溶液示出5500至7500mPa-s(cP)的黏度范围时,认为聚环氧乙烷具有5, 000, 000的近似分子量。 [0123] When using a Brookfield viscometer model RVF and No.2 rotor at 1% 2rpm measured at 25 ° C for the polyethylene oxide (by weight) aqueous solution to 5500 shown 7500mPa-s (cP) of when the viscosity range of polyethylene oxide having a 5,000, an approximate molecular weight of 000.

[0124] 当使用布氏黏度计RVF型和转子No. 2以2rpm在25°C下测量的聚环氧乙烷的1% (按重量计)水溶液示出7500至10, OOOmPa-S(CP)的黏度范围时,认为聚环氧乙烷具有7, 000, 000的近似分子量。 [0124] When using a Brookfield RVF viscometer rotor No. 2 type and in 1% 2rpm measured at 25 ° C for the polyethylene oxide (by weight) aqueous solution shows 7500 to 10, OOOmPa-S (CP ) when the viscosity range of polyethylene oxide having a 7,000, an approximate molecular weight of 000.

[0125] 当使用布氏黏度计RVF型和转子No. 2以2rpm在25°C下测量的聚环氧乙烷的1% (按重量计)水溶液示出10, 〇〇〇至15, OOOmPa-S(CP)的黏度范围时,认为聚环氧乙烷具有8, 000, 000的近似分子量。 [0125] When using a Brookfield RVF viscometer rotor No. 2 type and in 1% 2rpm measured at 25 ° C for the polyethylene oxide (by weight) aqueous 10 shows, 〇〇〇 to 15, OOOmPa when -S (CP) viscosity range, that having 8 polyethylene oxide, molecular weight approximately 000, 000.

[0126] 关于较低分子量聚环氧乙烷,当使用布氏黏度计RVT型和转子No. 1以50rpm和25°C下测量的聚环氧乙烷的5% (按重量计)水溶液示出30至50mPa-s (cP)的黏度范围时,认为聚环氧乙烧具有100,000的近似分子量。 [0126] For low molecular weight polyethylene oxide, when using a Brookfield RVT type viscometer and rotor No. 5% 1 following 50rpm, 25 ° C measured polyethylene oxide (by weight) aqueous solution shows when the 30 to 50mPa-s (cP) viscosity range, that polyethylene oxide having an approximate molecular weight of 100,000 to burn.

[0127] 当使用布氏黏度计RVF型和转子No. 2以2rpm在25°C下测量的聚环氧乙烷的5% (按重量计)水溶液示出8800至17,600mPa-s(cP)的黏度范围时,认为聚环氧乙烷具有900,000的近似分子量。 [0127] When using a Brookfield RVF viscometer rotor No. 2 type and in 5% 2rpm measured at 25 ° C for the polyethylene oxide (by weight) aqueous solution shows 8800 to 17,600mPa-s (cP) when the viscosity range of polyethylene oxide having an approximate molecular weight of 900,000.

[0128] 压制包衣剂型 [0128] press-coated dosage forms

[0129] 在利用压制包衣的一些实施方案中,优选地是,包衣中可药用赋形剂的全部或部分应赋予足够的压缩性以提供可药用产品。 [0129] In some embodiments, using a press-coated, it is preferable that the coating of all or a part of a pharmaceutically acceptable excipient should be sufficient to impart compressibility to provide a pharmaceutical product. 在预形成核心上的压制包衣部分取决于所选赋形剂和活性剂例如在聚合物溶解性、流动性、玻璃化转变温度等方面的单个特征。 Compression coating on a preformed core portion depends on the individual characteristics of the selected excipients and the active agent in a polymer, for example, solubility, fluidity, glass transition temperature and the like.

[0130] 可例如通过利用预制造的核心或在包衣前制备核心(例如,通过压制)来制备压制包衣剂型。 [0130] The core may be prepared for example by the use of the core prior to coating, or a pre-manufactured (e.g., by pressing) to prepare press-coated dosage forms. 可通过以下来制备内部核心:将活性剂与可药用赋形一起进行湿法制粒或干法制粒;然后干燥并且必要时磨碎以获得颗粒;添加任选的额外颗粒赋形剂和/或活性剂并适当共混;需要时添加润滑剂;以及采用压片机压制颗粒。 It can be prepared by the following inner core: the active agent together with a pharmaceutically acceptable excipient wet granulation or dry granulation; then dried and if necessary milled to obtain granules; adding optionally additional intragranular excipients and / or blending the active agent and appropriate; adding a lubricant when necessary; and employing particles tablet press. 在压制包衣之前,可任选地用功能性包衣或膜包衣对所得压制核心进行包衣。 Before compression coating, optionally resulting core press-coated with a functional coating or a film coating.

[0131] 可通过利用上文公开的任何控制释放材料与用于核心的共混物类似的方法制备用于压制包衣的共混物。 [0131] by using any controlled release material disclosed hereinabove for the blends prepared analogously core press-coated blend is used. 优选地,压制包衣包含聚环氧乙烷。 Preferably, compression coating comprises polyethylene oxide. 可通过压制将共混物包衣到核心上。 The blend can be compressed by coating to the core. 核心和/或包衣的压制可利用Killion或Fette旋转式压机以例如约1至约20 千牛顿的压制力进行。 The core and / or coating may be utilized Killion press or Fette rotary press pressing force, for example from about 1 to about 20 kN performed.

[0132] 在某些实施方案中,可利用Manesty Dry-Cota压机(例如,900型)。 [0132] In certain embodiments, it may be utilized Manesty Dry-Cota press (e.g., 900). 该装置由两台并排的相互连接的片压机组成,其中用一台压机制得核心,之后机械性地转移至下一个压机用于压制包衣。 The device consists of two press sheets interconnected side by side, where the pressure mechanism using a core obtained after mechanically transferred to the next press for compression coating. 每台压机具有独立的粉末进料机制,使得用一台机器加载核心共混物,另一台机器加载包衣共混物。 Each has a separate press powder feed mechanism, such that the core is loaded with a blend of the machine, the other machine loading coating blend. 机械转移臂在机器之间旋转以将核心从核心压机移除并将它们转移至包衣压机。 A robotic transfer arm to rotate between the machine and remove the core from the core press-coated transfer them to the press. 可用于制备本发明的剂型的其他压机包括Elizabeth Hata HT-AP44-MSU-C、Killian RLUD、和Fette PT 4090,其各自具有用于包衣共混物和预制核心的双进料系统。 Other presses may be used for the preparation of dosage forms of the present invention include Elizabeth Hata HT-AP44-MSU-C, Killian RLUD, and Fette PT 4090, each having a dual feed system for a pre-blend and coating the core. 利用这些压机使得通过回收已经压制包衣的片来实现多个压制包衣层。 With these presses that have been recovered by the sheet to achieve a plurality of press-coated press-coated layer. 所有这些压机均具有这样的机制,将片剂垂直地和放射状地置于包衣共混物内的中心。 All of these presses have such a mechanism, the tablets vertically and radially at the center of the coating blend.

[0133] 在某些实施方案中,在围绕内部核心的所有点上不以同一厚度施加压制包衣,而是以围绕内部核心的不同厚度施加。 [0133] In certain embodiments, compression coating is not applied at the same thickness at all points around the inner core, but with a different thickness is applied around the inner core. 包衣的较薄区域将产生将比其他区域更早从内部核心释放药物的压制剂型的区域。 Coated thinner region than other areas of the region generated earlier release of the drug from the dosage form compressed inner core. 这可例如通过在包衣时不将施加压制包衣的核心置于压机中心来简单地实现。 This can be simply achieved, for example, placed in a press center by not applying the core press-coated at a coating.

[0134] 在某些实施方案中,还可采用疏水性或肠溶性包衣材料对压制包衣剂型进行外包衣(overcoat)。 [0134] In certain embodiments, it may be a hydrophobic or enteric coating material to the press-coated dosage forms overcoated (overcoat). 在另一些实施方案中,可采用除了疏水性或肠溶性包衣之外的或者替代疏水性或肠溶性包衣的亲水性包衣对压制包衣剂型进行包衣。 In other embodiments, may be employed in addition to the hydrophobic or enteric coating, or alternatively a hydrophobic or enteric coating of a hydrophilic coating on coated press-coated dosage forms.

[0135] 在另一些实施方案中,可将任选的包衣(例如,疏水性、亲水性或肠溶性)可替换地或额外地施加为核心与压制包衣之间的中间层。 [0135] In other embodiments, an optional coating (e.g., hydrophobicity, hydrophilicity or enteric) may alternatively or additionally be applied as an intermediate layer between the core and the coating press.

[0136] 活性剂 [0136] The active agent

[0137] 用于本发明的阿片样镇痛剂包括,但不限于,阿芬太尼、烯丙罗定、阿法罗定、阿尼利定、苄吗啡、贝齐米特、丁丙诺啡、布托啡诺、氯尼他秦、可待因、地索吗啡、右吗拉胺、 地佐辛、地恩丙胺、二醋吗啡(diamorphone)、双氢可待因、双氢吗啡、地美沙朵、地美庚醇、 二甲噻丁、吗苯丁酯、地匹哌酮、依他佐辛、依索庚嗪、乙甲噻丁、乙基吗啡、依托尼秦、埃托啡、二氢埃托啡、芬太尼及衍生物、氢可酮、氢吗啡酮、羟哌替啶、异美沙酮、凯托米酮、左啡诺、左芬啡烷、洛芬太尼、哌替啶、美普他酚、美他佐辛、美沙酮、美托酮、吗啡、麦罗啡、那碎因(narceine)、尼可吗啡、去甲左啡诺、去甲美沙酮、稀丙吗啡、纳布啡(nalbuphene)、去甲吗啡、诺匹哌酮、阿片、轻考酮、轻吗啡酮、阿片全碱(papaveretum)、喷他佐辛、苯吗庚酮、非诺啡烧、非 [0137] opioid analgesic for the present invention include, but are not limited to, alfentanil, allyl Luoding, alphaprodine, anileridine, benzyl morphine, Beiqimite, buprenorphine , butorphanol, clonitazene, codeine, desomorphine, dextromoramide pull amines, dezocine, diampromide, diamorphine (diamorphone), dihydrocodeine, dihydroergotamine, morphine, Methadone duo, the United States heptanol, dimethenamid-butoxy, butyl benzene, to horses, risperidone, eptazocine, heptyl cable according oxazine, thiazole methyl acetate butyrate, ethylmorphine, etonitazene, etorphine, dihydroetorphine, fentanyl and derivatives, hydrocodone, hydromorphone, meperidine hydroxyalkyl, isobutyl methadone, ketobemidone, levorphanol, morphine left Fen alkoxy, lofentanil, for piperazine pyridine, meptazinol-, United States pentazocine, methadone, metopon, morphine, myrophine, narceine (narceine), Nicole morphine, norepinephrine levorphanol, norepinephrine methadone, morphine dilute propionate, sodium nalbuphine (nalbuphene), normorphine, norpipanone, opium, oxycodone light, light oxymorphone, papaveretum (papaveretum), pentazocine, benzene it heptanone, buprenorphine non-burning, non- 佐辛、苯哌利定、匹米诺定、哌腈米特、普罗庚嘆(propheptazine)、普鲁米多(promedol)、丙哌利定、丙氧芬、舒芬太尼、替利定、曲马多,其可药用盐、复合物(例如,与环糊精)、立体异构体、醚、酯、水合物、溶剂合物、以及混合物。 Metazocine, benzene piperazine vinzolidine, horses set minoxidil, piritramide, propheptazine sigh (propheptazine), multiple promethazine (promedol), prop-piperazine vinzolidine, propoxyphene, sufentanil, tilidine, , tramadol, pharmaceutically acceptable salts, complexes (e.g., cyclodextrin), stereoisomers thereof, ethers, esters, hydrates, solvates, and mixtures thereof.

[0138] 优选地,阿片样镇痛剂选自可待因、氢可酮、氢吗啡酮、吗啡、羟考酮、羟吗啡酮、曲马多,其可药用盐、复合物、立体异构体、醚、酯、水合物、溶剂合物、以及混合物。 [0138] Preferably, the opioid analgesic is selected from codeine, hydrocodone, hydromorphone, morphine, oxycodone, oxymorphone, tramadol, pharmaceutically acceptable salts, complexes, stereoisomers isomers, ethers, esters, hydrates, solvates, and mixtures thereof.

[0139] 在某些实施方案中,阿片样镇痛剂选自氢可酮,其可药用盐、复合物、立体异构体、醚、酯、水合物、溶剂合物、以及混合物。 [0139] In certain embodiments, the opioid analgesic is selected from hydrocodone, pharmaceutically acceptable salts, complexes, stereoisomers thereof, ethers, esters, hydrates, solvates, and mixtures thereof. 优选地,阿片样镇痛剂为重酒石酸氢可酮(hydrocodone bitartrate)〇 Preferably, the opioid analgesic is hydrocodone bitartrate (hydrocodone bitartrate) square

[0140] 根据本发明使用的阿片样物质可包含一个或多更个不对称中心,并且可产生对映体、非对映体或其他立体异构体形式。 [0140] may contain one or more asymmetric centers according to the present invention, the opioid used, and may give rise to enantiomers, a non-stereoisomeric forms, or other enantiomer. 本发明意指涵盖所有这种可能形式及其外消旋和拆分形式以及其组合物。 The present invention is intended to encompass all such possible forms as their racemic and resolved forms and compositions thereof. 当本文中描述的化合物包含烯双键或其他几何不对称性中心时,其旨在包括E和Z型的几何异构体二者。 When the compounds described herein contain olefinic double bonds or other centers of geometric asymmetry, it is intended to include both E and Z geometric isomers. 本发明还旨在包括所有的互变异构体。 The present invention is further intended to include all tautomers thereof.

[0141] 可药用盐包括,但不限于无机酸盐,例如盐酸盐、氢溴酸盐、硫酸盐、磷酸盐等;有机酸盐,例如甲酸盐、乙酸盐、三氟乙酸盐、马来酸盐、酒石酸盐等;磺酸盐,例如甲磺酸盐、 苯磺酸盐、对甲苯磺酸盐等;氨基酸盐,例如精氨酸盐、天冬酰胺盐、谷氨酸盐等;金属盐, 例如钠盐、钾盐、铯盐等;碱土金属盐,例如钙盐、镁盐等;以及有机胺盐,例如三乙胺盐、吡啶盐、甲基吡啶盐、乙醇胺盐、三乙醇胺盐、二环己胺盐、Ν,Ν' -双苄基乙二胺盐等。 [0141] Pharmaceutically acceptable salts include, but are not limited to, inorganic acid salts such as hydrochloride, hydrobromide, sulfate, phosphate and the like; organic acid salts such as formate, acetate, trifluoroacetate , maleate, tartrate and the like; sulfonates such as methanesulfonate, benzenesulfonate, p-toluenesulfonate and the like; amino acid salts such as arginine salt, asparagine, glutamate salts; metal salts such as sodium salt, potassium salt, cesium salt and the like; alkaline earth metal salts, such as calcium, magnesium and the like; and organic amine salts such as triethylamine salt, pyridine salt, picoline salt, ethanolamine salt , triethanolamine salt, dicyclohexylamine salt, Ν, Ν '- bis-dibenzylethylenediamine salt and the like.

[0142] 另外,根据本发明,可使用除了阿片样镇痛剂之外可能被滥用的活性剂。 [0142] Further, according to the present invention may be used in addition to the opioid analgesic active agent may be abused. 这样的活性剂包括例如安定剂(tranquilizer)、CNS抑制剂、CNS兴奋剂、镇静剂、催眠剂、兴奋剂(包括食欲抑制剂如苯丙醇胺)和大麻素类(cannabinoids)等。 Such agents include, for example, stabilizers (Tranquilizer), CNS inhibitors, CNS stimulants, sedatives, hypnotic agents, stimulants (including appetite suppressants such as phenylpropanolamine) and cannabinoids (of cannabinoids) and the like. 更具体地,活性剂可选自巴比妥类,例如苯巴比妥、司可巴比妥、戊巴比妥、仲丁比妥、他布比妥、阿普比妥、甲苯比妥、布他比妥,其可药用盐,等;苯二氮萆类,例如地西泮、氯氮萆、阿普唑仑、三唑仑、艾司唑仑、氯硝西泮、氟硝西泮,其可药用盐,等;兴奋剂,例如γ-羟基丁酸酯/盐(gamma-hydroxybutyrate)、右旋苯丙胺、哌甲醋、西布曲明、亚甲基二氧基甲基苯丙胺,其可药用盐,等;其他物质,例如屈大麻酚(marinol)、甲丙氨酯和卡立普多;及所有的其可药用盐、复合物、立体异构体、醚、酯、水合物、溶剂合物、以及混合物。 More specifically, the active agent may be selected from the barbiturates, e.g. phenobarbital, secobarbital, pentobarbital, sec-ratio properly, he duly cloth ratio, aprobarbital, mephobarbital, butalbital, pharmaceutically acceptable salts thereof, and the like; benzodiazepines castor type, e.g. diazepam, chlordiazepoxide castor seed, alprazolam, triazolam, estazolam, clonazepam, flunitrazepam West Pan, pharmaceutically acceptable salts thereof, and the like; stimulants, e.g. γ- hydroxybutyrate / salt (gamma-hydroxybutyrate), dextroamphetamine, methylphenidate piperazine, sibutramine, methylenedioxy methamphetamine , pharmaceutically acceptable salts thereof, and the like; other substances, for example, dronabinol (Marinol), meprobamate, and carisoprodol; and all pharmaceutically acceptable salts, complexes, stereoisomers thereof, ethers, esters , hydrates, solvates, and mixtures thereof.

[0143] 在另一些实施方案中,根据本发明,可单独或与阿片样物质组合使用另一些治疗性活性剂。 [0143] In other embodiments in accordance with the present invention, the opioid may be used alone or in combination with other therapeutically active agents. 这样的治疗性活性剂的实例包括抗组胺剂(例如,茶苯海明、苯海拉明、氯苯那敏和马来酸右氯苯那敏)、非留体抗炎剂(例如,萘普生、双氯芬酸、吲哚美辛、布洛芬、舒林酸、Cox-2抑制剂)、对乙酰氨基酚、镇吐剂(例如,甲氧氯普胺、甲基纳曲酮)、抗癫痫剂(例如,苯妥英(Phenyloin)、甲丙胺脂和硝西泮)、血管舒张剂(例如,硝苯地平、罂粟碱(papaverine)、地尔硫罩和尼卡地平)、镇咳剂和祛痰剂、平喘剂(例如茶碱)、抗酸剂、解痉剂(例如,阿托品、东莨菪碱)、抗糖尿病剂(例如,胰岛素)、利尿剂(例如,依他尼酸、苄氟噻嘆(bendrofluthiazide))、抗低血压药(例如,普萘洛尔、可乐定)、降压药(例如,可乐定、甲基多巴)、支气管扩张药(例如,沙丁胺醇)、类固醇类(例如,氢化可的松、曲安西龙、 泼尼松)、抗生素(例如,四 Examples of such therapeutically active agents include antihistamines (e.g., dimenhydrinate, diphenhydramine, chlorpheniramine and dexchlorpheniramine maleate), non-steroidal anti-inflammatory agents (e.g., naphthyl Poor Health, diclofenac, indomethacin, ibuprofen, sulindac, Cox-2 inhibitors), acetaminophen, antiemetic agents (e.g., metoclopramide, methylnaltrexone), anti- epilepsy agents (e.g., phenytoin (Phenyloin), lipid A propylamine and nitrazepam), vasodilators (e.g., nifedipine, papaverine (papaverine), diltiazem and nicardipine cover), antitussive agents and cured expectorant, antiasthmatic agents (e.g. theophylline), antacids, antispasmodics (e.g. atropine, scopolamine), antidiabetics (e.g., insulin), diuretics (e.g., ethacrynic acid, benzyl flufenacet sigh (bendrofluthiazide)), an anti-hypotensive agent (e.g., propranolol, clonidine), antihypertensive drugs (e.g., clonidine, methyldopa), bronchodilators (e.g., albuterol), steroids (e.g., hydrocortisone, triamcinolone, prednisone), antibiotics (e.g., tetrakis 素)、抗痔疮剂、精神药物(psychotropic)、止泻药、黏液溶解剂、减充血剂(例如,伪麻黄碱)、轻泻剂、维生素,及其可药用盐、复合物、立体异构体、醚、 酯、水合物、溶剂合物、以及混合物。 Hormone), an anti-hemorrhoid agents, psychotropic drugs (psychotropic), antidiarrheals, mucolytics, decongestants (e.g., pseudoephedrine), laxatives, vitamins, and their pharmaceutically acceptable salts, complexes, stereoisomers, ethers, esters, hydrates, solvates, and mixtures thereof.

[0144] 氢可酮实施方案 [0144] Hydrocodone embodiment

[0145] 本发明的控制释放口服剂型优选地包含约0. 5mg至约1250mg氢可酮或等价量的其可药用盐。 [0145] Oral controlled release dosage forms of the present invention preferably comprise from about 0. 5mg to about 1250mg hydrocodone or an equivalent amount of a pharmaceutically acceptable salt thereof. 在另一些实施方案中,所述剂型包含约2mg至约200mg氢可酮或等价量的其可药用盐,或者约16mg至约120mg氢可酮或等价量的其可药用盐。 In other embodiments, the dosage form comprising from about 2mg to about 200mg hydrocodone or an equivalent amount of a pharmaceutically acceptable salt thereof, or from about 16mg to about 120mg hydrocodone or an equivalent amount of a pharmaceutically acceptable salt thereof. 在某些优选的实施方案中,所述剂型包含约20mg、约30mg、约40mg、约60mg、约80mg、约IOOmg或约120mg重酒石酸氢可酮。 In certain preferred embodiments, the dosage form comprises about 20mg, about 30mg, about 40mg, about 60mg, about 80mg, about 120mg, or about IOOmg hydrocodone bitartrate.

[0146] 合适的氢可酮可药用盐包括重酒石酸氢可酮、重酒石酸氢可酮水合物、 盐酸氢可酮、对甲苯磺酸氢可酮、磷酸氢可酮、氢可酮缩氨基硫脲(hydrocodone thiosemicarbazone)、硫酸氢可酮、三氟乙酸氢可酮、氢可酮半五水合物、五氟丙酸氢可酮、氢可酮对硝基苯腙、氢可酮邻甲基肟、氢可酮缩胺基脲、氢溴酸氢可酮、黏酸氢可酮、 油酸氢可酮、氢可酮磷酸氢盐(hydrocodone phosphate dibasic)、氢可酮磷酸二氢盐(hydrocodone phosphate monobasic)、氢可酮无机盐、氢可酮有机盐、乙酸氢可酮三水合物、双(七氟丁酸)氢可酮、双(甲基氨基甲酸)氢可酮、双(五氟丙酸)氢可酮、双(吡啶羧酸)氢可酮、双(三氟乙酸)氢可酮、盐酸氢可酮水合物和硫酸氢可酮五水合物。 [0146] Suitable pharmaceutically acceptable salts of hydrocodone include hydrocodone bitartrate, hydrocodone bitartrate hydrate, hydrocodone hydrochloride hydrogen, hydrocodone p-toluenesulfonic acid, hydrogen phosphate, hydrocodone, hydrocodone ylideneamino thiourea (hydrocodone thiosemicarbazone), hydrocodone hydrogen sulfate, hydrogen trifluoroacetic acid hydrocodone, hydrocodone hemipentahydrate, hydrocodone pentafluoropropionate, hydrocodone p-nitrophenyl hydrazone, hydrocodone o- oxime, hydrocodone semicarbazone, hydrocodone hydrobromide, hydrocodone mucic, hydrocodone oleate, hydrocodone hydrogen phosphate (hydrocodone phosphate dibasic), hydrocodone dihydrogen phosphate (hydrocodone phosphate monobasic), hydrocodone inorganic salt, hydrocodone organic salt, hydrocodone acetate trihydrate hydrogen, bis (heptafluoro butyrate) hydrocodone bis (methylcarbamate) hydrocodone bis (pentafluoro propionic acid) hydrocodone bis (pyridine carboxylate) hydrocodone bis (trifluoroacetate) hydrocodone, hydrocodone hydrochloride monohydrate and potassium hydrogen sulfate pentahydrate hydrocodone. 优选地, 氢可酮以重酒石酸盐存在。 Preferably, to hydrocodone bitartrate salt.

[0147] 本发明的氢可酮剂型还可包含一种或更多种另外的药物,其可能或可能不与其中包含的氢可酮协同作用。 Hydrogen [0147] The present invention may be one dosage forms may contain one or more additional drugs or, which may or may not be hydrogen and one may be contained therein synergistically. 此类另外的药物的实例包括非留体抗炎剂,包括布洛芬、双氯芬酸、萘普生、苯.恶洛芬、氟比洛芬、非诺洛芬、氟布芬、酮洛芬、吲哚洛芬、吡洛芬、卡洛芬、奥沙普秦、普拉洛芬(pramoprofen)、莫罗洛芬(muroprofen)、三ρ恶洛芬(trioxaprofen)、舒洛芬、阿明洛芬(aminoprofen)、噻洛芬酸、氟洛芬、布氯酸、吲哚美辛、舒林酸、托美丁、佐美酸、硫平酸、齐多美辛、阿西美辛、芬替酸、环氯茚酸、oxpinac、甲芬那酸、甲氯芬那酸、氟芬那酸、尼氟酸、托芬那酸、二氟尼柳(diflurisal)、氟苯柳、吡罗昔康、舒多昔康、伊索昔康, 及其可药用盐、复合物、立体异构体、醚、酯、水合物、溶剂合物、以及混合物。 Examples of such additional drugs include non-steroidal anti-inflammatory agents, including ibuprofen, diclofenac, naproxen, benzene. Evil ketoprofen, flurbiprofen, fenoprofen, fluoro Bufen, ketoprofen, indoprofen, pirprofen, carprofen, oxaprozin, pranoprofen (pramoprofen), Morrow ibuprofen (muroprofen), three ρ evil ibuprofen (trioxaprofen), suprofen, alminoprofen (aminoprofen) , tiaprofenic acid, fluprofen, bucloxic acid, indomethacin, sulindac, tolmetin, zomepirac, quetiapine acid, indomethacin multi Qi, acemetacin, fentiazac acid, ring-chloro Sulindac, oxpinac, mefenamic acid, meclofenamic acid, flufenamic acid, niflumic acid, tolfenamic acid, diflunisal (diflurisal), flufenisal, piroxicam, sudoxicam, isoxicam, and pharmaceutically acceptable salts, complexes, stereoisomers thereof, ethers, esters, hydrates, solvates, and mixtures thereof. 这样的非甾体抗炎剂还包括环氧合酶抑制剂,例如塞来昔布(celecoxib)、美洛昔康、萘丁美酮、尼美舒利,及其可药用盐、复合物、立体异构体、醚、酯、水合物、溶剂合物、以及混合物。 Such non-steroidal anti-inflammatory agents also include cyclooxygenase inhibitors such as celecoxib (, celecoxib), meloxicam, nabumetone, nimesulide, and their pharmaceutically acceptable salts, complexes , stereoisomers thereof, ethers, esters, hydrates, solvates, and mixtures thereof.

[0148] 可与氢可酮共配制的另一些药物包括NMDA受体拮抗剂,例如右啡烷、右美沙芬、 3-(1-萘基)-5-(膦酰甲基)-L-苯丙氨酸、3-(1-萘基)-5-(膦酰甲基)-DL-苯丙氨酸、 1-(3,5_二甲基苯基)萘、2-(3,5_二甲基苯基)萘、2SR,4RS-4_(((1H-四唑-5-基)甲基) 氧基)哌啶-2_羧酸、251?,41«-4-((((1!1-四唑-5-基)甲基)氧基)甲基)哌啶-2-羧酸、E和Z 2SR-4-(0-(lH-四唑-5-基)甲基)酮肟基)哌啶-2-羧酸、2SR,4RS-4_((1H-四唑-5-基)硫基)哌啶-2-羧酸、2SR,4RS-4-((1H-四唑-5-基)硫基)哌啶-2-羧酸、2SR,4RS-4-(5-巯基-IH-四唑-1-基)哌啶-2-羧酸、2SR,4RS-4-(5-巯基-2H-四唑-2-基)哌啶-2-羧酸、2SR,4RS-4-(5-巯基-IH-四唑-1-基)哌啶-2-羧酸、2SR, 4RS-4-(5-巯基-2H-四唑-2-基)哌啶-2-羧酸、2SR,4RS-4_(((1H-四唑-5-基)硫基) 甲基)哌啶-2-羧酸、2SR,4RS-4-((5-巯基-IH-四唑-1-基)甲基)哌啶-2-羧酸、2SR, 4R Other drugs [0148] can be co-formulated with hydrocodone include NMDA receptor antagonists, e.g. dextrorphan, dextromethorphan, 3- (1-naphthyl) -5- (phosphonomethyl) -L- phenylalanine, 3- (1-naphthyl) -5- (phosphonomethyl) -DL-phenylalanine, 1- (3,5_ dimethylphenyl) naphthalene, 2- (3, 5_-dimethylphenyl) naphthalene, 2SR, 4RS-4 _ (((1H- tetrazol-5-yl) methyl) oxy) piperidine -2_ acid, 251?, 41 «4- ( (((1! 1- tetrazol-5-yl) methyl) oxy) methyl) piperidine-2-carboxylic acid, E and Z 2SR-4- (0- (lH- tetrazol-5-yl ) methyl) ketoximino) piperidine-2-carboxylic acid, 2SR, 4RS-4 _ ((1H- tetrazol-5-yl) thio) piperidine-2-carboxylic acid, 2SR, 4RS-4- ( (lH-tetrazol-5-yl) thio) piperidine-2-carboxylic acid, 2SR, 4RS-4- (5- mercapto -IH- tetrazol-1-yl) piperidine-2-carboxylic acid, 2SR , 4RS-4- (5- mercapto -2H- tetrazol-2-yl) piperidine-2-carboxylic acid, 2SR, 4RS-4- (5- mercapto -IH- tetrazol-1-yl) piperidine - 2- carboxylic acid, 2SR, 4RS-4- (5- mercapto -2H- tetrazol-2-yl) piperidine-2-carboxylic acid, 2SR, 4RS-4 _ (((1H- tetrazol-5-yl) thio) methyl) piperidine-2-carboxylic acid, 2SR, 4RS-4 - ((5- mercapto -IH- tetrazol-1-yl) methyl) piperidine-2-carboxylic acid, 2SR, 4R S-4-((5-巯基-2H-四唑-2-基)甲基)哌啶-2-羧酸,及其可药用盐、复合物、立体异构体、醚、酯、水合物、溶剂合物、以及混合物。 S-4 - ((5- mercapto -2H- tetrazol-2-yl) methyl) piperidine-2-carboxylic acid, and pharmaceutically acceptable salts, complexes, stereoisomers thereof, ethers, esters, hydrated solvates, and mixtures thereof.

[0149] 可包含在本发明氢可酮剂型中的其他合适的药物包括对乙酰氨基酚和阿司匹林。 Other suitable pharmaceutical [0149] may be included in the present invention, hydrocodone dosage form include acetaminophen, and aspirin.

[0150] 在一些优选的实施方案中,本发明的氢可酮制剂适合用于每天一次施用并且提供相对平直的血浆曲线,这意味着施用之后氢可酮的血浆水平提供约0. 55至约I. 0的C24/Cmax比率。 [0150] In some preferred embodiments, the present invention may be one of hydrogen formulation suitable for once-daily administration and provide a relatively flat plasma profile, which means that after administration of hydrocodone plasma levels to provide from about 0.55 about I. C24 / Cmax ratio of 0. 在某些实施方案中,施用所述剂型之后C24/Cmax比率为约0. 55至约0. 85、约0. 55至约0. 75或约0. 60至约0. 70。 In certain embodiments, C24 / Cmax ratio after administration of the dosage form is from about 0.55 to about 0.85, from about 0.55 to about 0.75, or about 0.60 to about 0.70.

[0151] 在一些优选的实施方案中,施用之后本发明的氢可酮制剂提供约4至约20小时的氢可酮的Tmax(h)。 [0151] In some preferred embodiments, the present invention after administration of the hydrogen hydrocodone formulation to provide from about 4 to about 20 hours hydrocodone Tmax (h). 在某些实施方案中,施用所述剂型之后T_x为约6至约12小时、约8至约10小时、约4至约10小时、约8至约14小时或约14至约20小时。 T_x of from about 6 to about 12 hours, from about 8 to about 10 hours, from about 4 to about 10 hours, from about 8 to about 14 hours, or from about 14 to about 20 hours after In certain embodiments, the dosage form is administered.

[0152] 在另一些实施方案中,施用之后本发明的固体控制释放剂型每20mg在剂型中包含的氢可酮或其可药用盐提供约200至450或约250至400的AUC (ng * h/mL)。 [0152] In other embodiments, the administration after the solid controlled release dosage form of the present invention, each of 20mg of hydrogen contained in the dosage form of oxycodone or a pharmaceutically acceptable salt thereof provides AUC of about 200 to 450 or about 250 to 400 (ng * h / mL).

[0153] 在某些实施方案中,施用之后包含20mg氢可酮或其可药用盐的固体控制释放剂型提供约200至约450、约250至约400、约275至约350、约300至330或约280至约320 的AUC(ng * h/mL)。 [0153] In certain embodiments, after administration of 20mg comprising hydrocodone or a pharmaceutically acceptable salt thereof solid controlled release dosage form to provide from about 200 to about 450, from about 250 to about 400, from about 275 to about 350, from about 300 to about 330 or about 280 to 320 AUC (ng * h / mL).

[0154] 在某些实施方案中,施用之后包含120mg氢可酮或其可药用盐的固体控制释放剂型提供约1000至约3000、约1500至约2400、约1700至约2200、约1800至约2100或约1900 至约2100 的AUC(ng * h/mL)。 [0154] In certain embodiments, after administration of 120mg comprises hydrocodone or a pharmaceutically acceptable salt thereof in solid controlled release dosage form to provide from about 1000 to about 3000, from about 1500 to about 2400, from about 1700 to about 2200, from about 1800 to about 2100 or from about 1900 to about 2100 AUC (ng * h / mL).

[0155] 在另一些实施方案中,施用之后本发明的固体控制释放剂型每20mg在剂型中包含的氢可酮提供约5至约40、约10至约30的Cniax (ng/mL)。 [0155] In other embodiments, the present invention after administering the solid controlled release dosage form hydrogen 20mg per dosage form may be contained in one to provide from about 5 to about 40, from about 10 to Cniax (ng / mL) of about 30.

[0156] 在某些实施方案中,施用之后包含20mg氢可酮或其可药用盐的固体控制释放剂型提供约5至约40、约10至约30、约12至约25、约14至约18或约12至约17的Cniax (ng/ mL)。 [0156] In certain embodiments, after administration of 20mg comprising hydrocodone or a pharmaceutically acceptable salt thereof solid controlled release dosage form to provide from about 5 to about 40, from about 10 to about 30, from about 12 to about 25, from about 14 to Cniax about 18, or about 12 to about 17 (ng / mL).

[0157] 在某些实施方案中,施用之后包含120mg氢可酮或其可药用盐的固体控制释放剂型提供约30至约120、约60至约180、约100至约160、约110至约150或约100至约140 的Cmax (ng/mL)。 [0157] In certain embodiments, after administration of 120mg comprises hydrocodone or a pharmaceutically acceptable salt thereof in solid controlled release dosage form to provide from about 30 to about 120, from about 60 to about 180, from about 100 to about 160, from about 110 to Cmax of about 150 or about 100 to about 140 (ng / mL).

[0158] 在某些实施方案中,施用之后本发明的固体控制释放剂型提供的约7至约22、10 至约20、约12至约18、约13至约17或约14至约16氢可酮的Imax(h)。 [0158] In certain embodiments, after administration of the solid controlled release dosage form of the present invention provide from about 7 to about 22, 10 to about 20, from about 12 to about 18, from about 13 to about 17, or about 14 to about 16 hydrogen oxycodone Imax (h).

[0159] 在另一些实施方案中,施用之后本发明的固体控制释放剂型提供约5至约10、约6 至约9、约7或约8的氢可酮的T1/2 (h)。 [0159] In other embodiments, the present invention after administration of the solid controlled release dosage form to provide from about 5 to about 10, from about 6 to about 9, about 7, or about 8 hydrogen may be one of T1 / 2 (h).

[0160] 在另一些实施方案中,施用之后本发明的固体控制释放剂型提供约0.01至约0. 2、约0. 1至约0. 18、约0. 3至约0. 17或约0. 06至约0. 15的氢可酮的TlagQi)。 [0160] In other embodiments, the present invention after administering the solid controlled release dosage form to provide from about 0.01 to about 0.2, from about 0.1 to about 0.18, from about 0.3 to about 0.17, or about 0 hydrogen 06 to about 0.15 may ketone TlagQi).

[0161] 在另一些实施方案中,本发明的固体控制释放剂型提供约0. 2至约0. 8、约0. 3至约0. 7或约0. 4至约0. 6的氢可酮的C24/C_比率。 [0161] In other embodiments, the present invention is a solid controlled release dosage form to provide from about 0.2 to about 0.8, from about 0.3 to about hydrogen 0.7, or about 0.4 to about 0.6 may be ketones C24 / C_ ratio.

[0162] 在某些实施方案中,在禁食状态(fasted state)下施用后达到上述平均体内参数中的任一种或全部。 [0162] In certain embodiments, after administration in the fasted state (fasted state) reaches any one or all of the above average vivo parameters.

[0163] 在某些实施方案中,在进食状态(fed state)下施用后氢可酮的平均AUC(ng * h/mL)比在禁食状态下施用后氢可酮的AUC (ng * h/mL)高出不到20%、不到16 %或不到12%〇 [0163] In certain embodiments, in the fed state mean AUC (ng * h / mL) after administration of the hydrocodone (fed state) of hydrogen than in the fasted state after administration of oxycodone AUC (ng * h / mL) higher than 20%, less than 16%, or less than 12% square

[0164] 在某些实施方案中,在进食状态下施用后氢可酮的平均Cmax (ng/mL)比在禁食状态下施用后氢可酮的Cmax高出不到80%、不到70%或不到60%。 [0164] In certain embodiments, the mean Cmax in the fed state after administration of hydrocodone (ng / mL) than after administration in the fasted state Cmax of hydrocodone higher than 80%, less than 70 % or less than 60%.

[0165] 在某些实施方案中,在进食状态下施用后氢可酮的平均TmaxQi)为在禁食状态下施用后氢可酮的Tmax的25%以内、20%以内或15%以内。 [0165] In certain embodiments, after administration in the fed state hydrocodone average TmaxQi) ​​is within 25% after administration in the fasted state Tmax of hydrocodone, within 20% or 15% or less.

[0166] 在某些实施方案中,在进食状态下施用后氢可酮的平均T1/2(h)为在禁食状态下施用后T1/2的8%以内、5%以内或2%以内。 In certain embodiments, within in the fed state after administration of hydrocodone average T1 / 2 (h) of 8% T1 / 2 is in the fasted state after administration, less than 5% or less [0166] or 2% .

[0167] 在某些实施方案中,在进食状态下施用后氢可酮的平均Tlag比在禁食状态下施用后的Τ1/2高出不到150%、不到125%或不到100%。 [0167] In certain embodiments, the average Tlag after administration in the fed state hydrocodone is less than 150% higher than Τ1 / 2 after administration in the fasted state, is less than 125%, or less than 100% .

[0168] 在某些实施方案中,在向人对象、患者或健康对象(个体数据)或者人对象、患者或健康对象的群体(平均数据)首次施用所述剂型后达到上述体内参数中的任一种或全部。 [0168] In certain embodiments, when the human subject, patient or healthy subject (individual data) or human subjects, group (mean data) patients or healthy subject is administered a first dosage form as in any one of the above parameters in vivo one or all of them.

[0169] 在某些替代实施方案中,在向人对象、患者或健康对象或者人对象、患者或健康对象的群体稳态施用所述剂型后达到上述体内参数中的任一种或全部。 [0169] In certain alternative embodiments, to the human subject, patient or healthy subjects or human subject, after steady state administration of the dosage form the patient or population of healthy subjects achieve any or all of the above parameters in vivo.

[0170] 熟化制剂 [0170] curing agents

[0171] 在某些实施方案中,本发明的方法还包括使最终剂型熟化(curing)的步骤。 [0171] In certain embodiments, the present invention further comprises a method of making the final dosage form is cured (Curing) steps.

[0172] 对于在控制释放制剂中包含聚环氧乙烷的实施方案,熟化步骤可包括至少部分地熔化制剂中的聚环氧乙烷。 [0172] For the embodiment comprises polyethylene oxide in a controlled release formulation, the curing step may include polyethylene oxide at least partially melts formulation. 在某些实施方案中,制剂中的至少约20%或至少约30%的聚环氧乙烷发生熔化。 In certain embodiments, at least about 20% of the formulation or at least about 30% polyethylene oxide melts. 优选地,在熟化步骤期间,制剂中的至少约40%、或至少约50%、或至少约60 %、或至少约75 %、或至少约90 %的聚环氧乙烷发生熔化。 Preferably, during the curing step, the formulation is at least about 40%, or at least about 50%, or at least about 60%, or at least about 75%, or at least about 90% polyethylene oxide melts. 在一个优选的实施方案中, 约100%的聚环氧乙烷发生熔化。 In a preferred embodiment, about 100% polyethylene oxide melts.

[0173] 在另一些实施方案中,熟化步骤包括使制剂经受一段时间升高的温度。 [0173] In other embodiments, the curing step includes subjecting the formulation elevated temperatures over time. 在这样的一些实施方案中,熟化温度至少与聚环氧乙烷的软化温度一样高。 In some such embodiments, the curing temperature is at least as high as the softening temperature of the polyethylene oxide. 根据某些实施方案,熟化温度为至少约60°C、至少约62°C,约62°C至约90°C、约62°C至约85°C、约62°C至约80°C、 约65 °C至约90 °C、约65 °C至约85°C或约65 °C至约80 °C。 According to certain embodiments, the curing temperature is at least about 60 ° C, at least about 62 ° C, about 62 ° C to about 90 ° C, about 62 ° C to about 85 ° C, about 62 ° C to about 80 ° C , about 65 ° C to about 90 ° C, about 65 ° C to about 85 ° C or about 65 ° C to about 80 ° C. 熟化温度优选地为约68°C至约90°C、约68°C至约85°C、约68°C至约80°C、约70°C至约90°C、约70°C至约85°C、约70°C至约80°C、约72°C至约90°C、约72°C至约85°C或约72°C至约80°C。 Aging temperature is preferably from about 68 ° C to about 90 ° C, about 68 ° C to about 85 ° C, about 68 ° C to about 80 ° C, about 70 ° C and about 90 ° C, about 70 ° C and about 85 ° C, about 70 ° C and about 80 ° C, about 72 ° C to about 90 ° C, about 72 ° C to about 85 ° C or about 72 ° C to about 80 ° C. 熟化温度可以为至少约60°C、至少约62°C、低于约90°C或低于约80°C。 Curing temperature of at least about 60 ° C, at least about 62 ° C, below about 90 ° C or less than about 80 ° C. 优选地,其在约62°C至约72°C或约68°C至约72°C的范围中。 Preferably, it is at about 62 ° C to about 72 ° C or about 68 ° C to a range of about 72 ° C. 优选地,熟化温度至少与聚环氧乙烷之软化温度范围的下限一样高,或者为至少约62°C或至少约68°C。 Preferably, the curing temperature is at least as high as the lower limit of the softening temperature range of the polyethylene oxide or at least about 62 ° C or at least about 68 ° C. 更优选地,熟化温度在聚环氧乙烷的软化温度范围内或为至少约70°C。 More preferably, the curing temperature is within the softening temperature range of the polyethylene oxide or at least about 70 ° C. 在另一些实施方案中,熟化温度至少与聚环氧乙烷之软化温度范围的上限一样高或为至少约72°C。 In other embodiments, the curing temperature is at least as high as the upper limit of the softening temperature range of the polyethylene oxide or at least about 72 ° C. 在另一些实施方案中,熟化温度高于聚环氧乙烷之软化温度范围的上限,或者为至少约75°C或至少约80°C。 In other embodiments, the curing temperature is higher than the upper limit of the softening temperature range of the polyethylene oxide or at least about 75 ° C or at least about 80 ° C.

[0174] 在那些其中熟化步骤涉及使制剂经受一段时间升高的温度的实施方案中,该段时间在后文中称为熟化时间(curing time)。 Embodiment [0174] In those wherein the formulation is subjected to the curing step involves raising the temperature in a period of time, the period of time hereinafter referred to as the curing time (curing time). 为了测量熟化时间,定义了熟化步骤的起始点(starting point)和结束点(end point)。 In order to measure the curing time, the curing step defines the starting point (starting point) and end point (end point). 对于本发明的目的而言,将熟化步骤的起始点定义为达到熟化温度时的时间点。 For the purposes of the present invention, the starting point of the curing step is defined as the point in time when the curing temperature is reached.

[0175] 在某些实施方案中,熟化步骤期间的温度曲线显示熟化起始点和结束点之间为平台样形式(plateau-like form)。 [0175] In certain embodiments, the temperature profile during the curing step of curing between the display start and end points for the plateau-like form (plateau-like form). 在这样的实施方案中,将熟化步骤的结束点定义为当加热结束或至少降低(例如通过结束或降低加热和/或通过开始随后的冷却步骤)并且温度随后降至比熟化温度低超过约KTC和/或降至聚环氧乙烷之软化温度范围的下限以下(例如低于约62°C)时的时间点。 In such embodiments, the end point of the curing step is defined or at least reduced when the end of heating (e.g. by terminating or reducing the heating and / or by starting a subsequent cooling step) and the temperature subsequently drops below the curing temperature by more than about KTC the point in time when the lower limit of the softening and / or polyethylene oxide fell below the temperature range (e.g., below about 62 ° C). 当达到熟化温度并因此开始熟化步骤时,在熟化步骤过程中可出现熟化温度的偏差。 When the curing temperature is reached and thus the start of the curing step, curing can be variation in the temperature occurs during the curing step. 只要这些偏差值不超过约±l〇°C、优选约±6°C并且更优选约±3°C,这样的偏差是可以忍受的。 As long as the deviation does not exceed about ± l〇 ° C, preferably about ± 6 ° C and more preferably about ± 3 ° C, such deviations can be tolerated. 例如,如果维持至少约75°C的熟化温度,则所测温度可以暂时升高至约85°C、约81°C或约78°C的值,以及所测温度也可以暂时降低至约65°C、 约69°C或约72°C的值。 For example, if the curing temperature is maintained at least about 75 ° C, the measured temperature may temporarily rise to about 85 ° C, or a value of about 81 ° C to about 78 ° C, and the measured temperature may also be temporarily reduced to about 65 ° C, or a value of about 69 ° C to about 72 ° C. 在温度降低更大和/或在温度降低至聚环氧乙烷之软化温度范围的下限以下(例如约62°C以下)的情况中,熟化步骤被中断,即达到结束点。 Greater reduction in the temperature and / or reduced to a case where the lower limit of the softening temperature of polyethylene oxide is less temperature range (e.g., about 62 ° C or less), the curing step is interrupted, i.e. end point is reached. 可通过再次达到熟化温度来重新开始熟化。 By curing temperature is reached again to re-start ripening.

[0176] 在另一些实施方案中,熟化步骤期间的温度曲线显示熟化起始点和结束点之间为抛物线形式或三角形形式。 [0176] In other embodiments, the temperature profile during the curing step shows a parabolic or triangular form between the starting point and end point of ripening. 这意味着起始点(即达到熟化温度时的时间点)之后温度进一步升高至达到最大值,然后下降。 This means that after the starting point (i.e., point in time when the curing temperature is reached) the temperature is further increased to reach a maximum, and then decreases. 在这样的一些实施方案中,将熟化步骤的结束点定义为温度降至熟化温度以下时的时间点。 In some such embodiments, the end point of the curing step is defined as the point in time when the temperature dropped below the curing temperature.

[0177] 取决于熟化所用的设备(即,熟化装置),可测量熟化装置内的不同温度以表征熟化温度。 Device (i.e., curing apparatus) [0177] used depending on the maturing be measured at different temperatures within the curing device to characterize the curing temperature.

[0178] 在某些实施方案中,可在烘箱中进行熟化步骤。 [0178] In certain embodiments, the curing step may be carried out in an oven. 在这样的一些实施方案中,测量烘箱内部温度。 In some such embodiments, the oven internal temperature measurement. 基于此,当熟化步骤在烘箱中发生时,将熟化温度定义为烘箱的目标内部温度,并且将熟化步骤的起始点定义为烘箱内部温度达到熟化温度时的时间点。 Based on this, when the curing step takes place in an oven, the curing temperature is defined as the target internal temperature of the oven and the starting point of the curing step is defined as the internal temperature of the oven reaches the point in time when the curing temperature. 将熟化步骤的结束点定义为(1)在平台样温度曲线中,当停止或至少降低加热并且随后烘箱内部温度降至比熟化温度低超过约KTC和/或降至高分子量聚环氧乙烷之软化温度范围的下限以下(例如约62°C以下)时的时间点,或者(2)在抛物线形或三角形温度曲线中,当烘箱内部温度降至熟化温度以下时的时间点。 The end point of the curing step is defined as (1) in a plateau-like temperature profile, when the heating is stopped or at least reduced and the temperature subsequently drops below the curing oven internal temperature lower than about KTC and / or reduced high molecular weight polyethylene oxide below the lower limit of the softening temperature range (e.g., about 62 ° C or less) at a time point, or (2) in a parabolic or triangular temperature profile, when the internal temperature drops below the curing oven temperature point in time. 优选地,当烘箱内部温度达到至少约62°C、至少约68°C、至少约70°C、至少约72°C或至少约75°C的熟化温度时开始熟化步骤。 Preferably, when the oven internal temperature of at least about 62 ° C, at least about 68 ° C, at least about 70 ° C, the aging temperature is at least about 72 ° C or at least about 75 ° C curing step starts. 在一些优选实施方案中,熟化步骤期间的温度曲线显示了平台样形式,其中熟化温度(即烘箱的内部温度)为至少约68°C、约70°C、约72°C、约73°C,或处于约70°C至约75°C的范围内,并且熟化时间优选地为约30分钟至约20小时、约30分钟至约15小时、约30分钟至约4小时或约30分钟至约2小时。 In some preferred embodiments, the temperature profile during the curing step shows a plateau-like form, wherein the curing temperature (i.e., the internal temperature of the oven) is at least about 68 ° C, about 70 ° C, about 72 ° C, about 73 ° C , or at about 70 ° C and in the range of about 75 ° C, and the curing time is preferably about 30 minutes to about 20 hours, about 30 minutes to about 15 hours, about 30 minutes to about 4 hours or from about 30 minutes to about 2 hours. 在某些实施方案中,熟化时间为约30分钟至约90分钟。 In certain embodiments, the curing time is about 30 minutes to about 90 minutes.

[0179] 在另一些的实施方案中,熟化发生在通过气流加热并且包含热空气供给(入口) 和排气口(exhaust)的熟化装置中,例如包衣锅或流化床。 [0179] In other embodiments, the curing takes place in the gas flow and is heated by hot air supply (inlet) and an exhaust port comprising (Exhaust) of the curing unit, for example a coating pan or fluidized bed. 下文中将这种熟化装置称为对流式熟化装置。 Such curing devices will hereinafter be called convection curing devices. 在这样的熟化装置中,可测量入口空气温度(即进入对流式熟化装置的加热空气的温度)和/或排气口空气温度(即离开对流式熟化装置的空气的温度)。 In such curing devices, measure the inlet air temperature (i.e. the temperature of the heated air entering the convection curing device) and / or exhaust air outlet temperature (i.e. the temperature of the air leaving the convection curing device). 还可在熟化步骤期间测量或至少估计对流式熟化装置内部的制剂温度,例如通过使用红外测温仪(例如IR枪(IR gun))或使用置于熟化装置内部的位于制剂附近的温度探针测量温度。 At least formulations may also be measured or estimated temperature inside the convection curing device during the curing step, for example by using an infrared thermometer (such as an IR gun (Gun IR)) or using the temperature probe was placed inside the curing device near the formulation is located measure temperature. 基于此,当熟化步骤在对流式熟化装置中发生时,可如下定义熟化温度和测量熟化时间。 Based on this, when the curing step takes place in a convection curing device, the curing temperature can be defined as follows and the curing time is measured.

[0180] 在一个实施方案中(方法1),将熟化温度定义为目标入口空气温度,并且将熟化步骤的起始点定义为入口空气温度达到熟化温度时的时间点。 [0180] In one embodiment (Method 1), the curing temperature is defined as a target inlet air temperature and the starting point of the curing step is defined as the inlet air temperature reaches the point in time when the curing temperature. 将熟化步骤的结束点定义为(1)在平台样温度曲线中,当停止或至少降低加热并且随后入口空气温度降至比熟化温度低超过约10°c和/或降至高分子量聚环氧乙烷之软化温度范围的下限以下(例如约62°C 以下)时的时间点,或者(2)在抛物线形式或三角形形式的温度曲线中,当入口空气温度降至熟化温度以下时的时间点。 The end point of the curing step is defined as (1) in a plateau-like temperature profile, when the heating is stopped or at least reduced and the inlet air temperature subsequently drops below the curing temperature by more than about 10 ° c and / or reduced high molecular weight polyethylene oxide the lower limit of the softening temperature range alkoxy or less (e.g., about 62 ° C or less) at a time point, or (2) in the form of a parabolic or triangular temperature profile form, when the inlet air temperature drops below the curing temperature point in time. 优选地,当入口空气温度达到至少约62°C、至少约68°C、至少约70°C、至少约72°C或至少约75°C的熟化温度时,根据方法1开始熟化步骤。 Preferably, when the inlet air temperature reaches at least about 62 ° C, at least about 68 ° C, the aging temperature is at least about 70 ° C, at least about 72 ° C or at least about 75 ° C, the curing step starts according to method 1. 在一个优选实施方案中,熟化步骤期间的温度曲线显示了平台样形式,其中熟化温度(即目标入口空气温度)优选地为至少约72°C,例如约75°C,并且根据方法1测量的熟化时间优选地为约15分钟至约2小时,例如约30分钟或约1小时。 In a preferred embodiment, the temperature profile during the curing step shows a plateau-like form, wherein the curing temperature (i.e. the target inlet air temperature) is preferably at least about 72 ° C, for example about 75 ° C, and a measurement according to the method the curing time is preferably from about 15 minutes to about 2 hours, for example about 30 minutes or about 1 hour.

[0181] 在另一个实施方案中(方法2),将熟化温度定义为目标排气口空气温度,并且将熟化步骤的起始点定义为排气口空气温度达到熟化温度时的时间点。 [0181] In another embodiment (Method 2), the curing temperature is defined as a target temperature air exhaust port, and the starting point of the curing step is defined as the point in time when the exhaust port air temperature reaches the curing temperature. 将熟化步骤的结束点定义为(1)在平台样温度曲线中,当停止或至少降低加热并且随后排气口空气温度降至比熟化温度低超过约10°c和/或降至高分子量聚环氧乙烷之软化温度范围的下限以下(例如约62°C以下)时的时间点,或者(2)在抛物线形式或三角形形式的温度曲线中,当排气口空气温度降至熟化温度以下时的时间点。 The end point of the curing step is defined as (1) in a plateau-like temperature profile, when the heating is stopped or at least reduced and the exhaust port subsequently drops below the curing temperature of the air temperature by more than about 10 ° c and / or reduced high molecular weight polyethylene ring the lower limit of the softening temperature range of ethylene oxide or less (e.g., about 62 ° C or less) at a time point, or (2) in the form of a parabolic or triangular temperature profile form, when the air vent when the temperature drops below the curing temperature the point in time. 优选地,当排气口空气温度达到至少约62°C、 至少约68°C、至少约70°C、至少约72°C或至少约75°C的熟化温度时根据方法2开始熟化步骤。 Preferably, the air vent when the temperature reaches at least about 62 ° C, at least about 68 ° C, at least about 70 ° C, according to the method of the aging temperature is at least about 72 ° C or at least about 75 ° C the curing step 2 begins. 在一些优选的实施方案中,熟化步骤期间的温度曲线显示了平台样形式,其中熟化温度(即目标排气口空气温度)优选地为至少约68°C、至少约70°C或至少约72°C,例如目标排气口空气温度为约68°C、约70°C、约72°C、约75°C或约78°C,并且根据方法2测量的熟化时间优选地为约1分钟至约2小时或约5分钟至约90分钟,例如熟化时间为约5分钟、约10 分钟、约15分钟、约30分钟、约60分钟、约70分钟、约75分钟或约90分钟。 In some preferred embodiments, the temperature profile during the curing step shows a plateau-like form, wherein the curing temperature (i.e. the target exhaust air outlet temperature) is preferably at least about 68 ° C, at least about 70 ° C or at least about 72 ° C, for example the target exhaust air outlet temperature of about 68 ° C, about 70 ° C, about 72 ° C, or from about 75 ° C to about 78 ° C, and for about 1 minute. the method of measuring the curing time is preferably 2 to about 2 hours or from about 5 minutes to about 90 minutes, for example the curing time is about 5 minutes, about 10 minutes, about 15 minutes, about 30 minutes, about 60 minutes, about 70 minutes, about 75 minutes or about 90 minutes. 在一个更优选的实施方案中,根据方法2测量的熟化时间为约15分钟至约1小时。 In a more preferred embodiment, the method according to the curing time is measured about 15 minutes to about 1 hour.

[0182] 在另一个实施方案中(方法3),将熟化温度定义为制剂的目标温度,并且将熟化步骤的起始点定义为制剂的温度(可例如通过IR枪测量)达到熟化温度时的时间点。 [0182] In another embodiment (Method 3), the curing temperature is defined as a target temperature of the formulation, and the starting point of the curing step is defined as the temperature of the formulation (for example, by measuring the IR gun) reaches the time when the curing temperature point. 将熟化步骤的结束点定义为(1)在平台样温度曲线中,当停止或至少降低加热并且随后制剂的温度降至比熟化温度低超过约l〇°C和/或降至高分子量聚环氧乙烷之软化温度范围的下限以下(例如约62°C以下)时的时间点,或者(2)在抛物线形式或三角形式的温度曲线中,当制剂的温度降至熟化温度以下时的时间点。 The end point of the curing step is defined as (1) in a plateau-like temperature profile, when the heating is stopped or at least reduced and the temperature subsequently drops below the curing temperature of the formulation is lower than about l〇 ° C and / or reduced high molecular weight polyethylene the lower limit of the softening temperature range of ethane or less (e.g. about 62 ° C or less) at a time point, or (2) at a temperature profile of a parabolic or triangular form in the formulation when the temperature drops below the curing temperature of the time point . 优选地,当制剂的温度达到至少约62°C、 至少约68°C、至少约70°C、至少约72°C或至少约75°C的熟化温度时根据方法3开始熟化步骤。 Preferably, when the temperature of the formulation is at least about 62 ° C, at least about 68 ° C, according to the method of the aging temperature is at least about 70 ° C, at least about 72 ° C or at least about 75 ° C the curing step 3 begins.

[0183] 在另一个实施方案中(方法4),将熟化温度定义为使用置于熟化装置内部的位于制剂附近的温度探针(例如金属线热电偶(wire thermocouple))测量的目标温度,并且将熟化步骤的起始点定义为使用温度探针测量的温度达到熟化温度时的时间点。 [0183] In another embodiment (Method 4), the curing temperature is defined as the use of the device placed inside the curing temperature probe located in the vicinity of the formulation (e.g., wire thermocouple (wire thermocouple)) measured target temperature, and the starting point of the curing step is defined as the temperature measured using the temperature probe reaches a point in time when the curing temperature. 将熟化步骤的结束点定义为(1)在平台样温度曲线中,当停止或至少降低加热并且随后使用温度探针测量的温度降至比熟化温度低超过约10°c和/或降至聚环氧乙烷之软化温度范围的下限以下(例如约62°c以下)时的时间点,或者(2)在抛物线形式或三角形形式的温度曲线中,当使用温度探针测量的温度降至熟化温度以下时的时间点。 The end point of the curing step is defined as (1) in a plateau-like temperature profile, when the heating is stopped or at least reduced and then measured using the temperature probe drops below the curing temperature by more than about 10 ° c and / or reduced poly the lower limit of the softening temperature range of ethylene oxide or less (e.g., about 62 ° c or less) at a time point, or (2) in the form of a parabolic or triangular temperature profile form, when the temperature measured using the temperature probe drops below the curing point in time when the temperature. 优选地,当使用温度探针测量的温度在熟化装置中达到至少约62°C、至少约68°C、至少约70°C、至少约72°C或至少约75°C的温度,开始熟化步骤。 Preferably, when the temperature measured using the temperature probe reaches the curing means at least about 62 ° C, at least about 68 ° C, at least about 70 ° C, a temperature of at least about 72 ° C or at least about 75 ° C and start maturation step. 在一个优选的实施方案中,熟化步骤期间的温度曲线显示了平台样形式,其中熟化温度为至少约68°C,例如约70°C,并且根据方法4测量的熟化时间优选地为约15分钟至约2小时或者约60分钟或约90分钟。 In a preferred embodiment, the temperature profile during the curing step shows a plateau-like form, wherein the curing temperature is at least about 68 ° C, for example about 70 ° C, and according to method 4 measuring the curing time is preferably from about 15 minutes to about 2 hours, or about 60 minutes or about 90 minutes.

[0184] 如果熟化发生在对流式熟化装置中,则可通过上述方法中的任何一种测量熟化时间。 [0184] If curing takes place in a convection curing device, the curing time can be measured by any of the methods described above.

[0185] 在某些实施方案中,将熟化温度定义为目标温度范围,例如将熟化温度定义为目标入口空气温度范围或目标排气口空气温度范围。 [0185] In certain embodiments, the curing temperature is defined as a target temperature range, for example the curing temperature is defined as a target inlet air temperature range or a target exhaust air temperature range port. 在这样的实施方案中,将熟化步骤的起始点定义为达到目标温度范围之下限时的时间点,将熟化步骤的结束点定义为当停止或至少降低加热并且随后温度降至比目标温度范围的下限低超过约l〇°C和/或降至聚环氧乙烷之软化温度范围的下限以下(例如约62°C以下)时的时间点。 In such embodiments, the starting point of the curing step is defined as a point in time to reach the target temperature range below the limit, the end point of the curing step is defined as when the heating is stopped or at least reduced and the temperature subsequently drops below the target temperature range the lower limit of the time point by more than about l〇 ° C, and the softening / polyethylene oxide or falls below the lower limit of the temperature range (e.g., about 62 ° C or less) when.

[0186] 可例如根据上述方法测量的熟化时间(即制剂经受熟化温度的一段时间)为至少约1分钟或至少约5分钟。 [0186] The aging time can be measured, for example, the method described above (i.e., the curing temperature of the formulation is subjected to a period of time) of at least about 1 minute or at least about 5 minutes. 取决于具体的制剂和熟化温度,熟化时间可为约1分钟至约24 小时、约5分钟至约20小时、约10分钟至约15小时、约15分钟至约10小时或约30分钟至约5小时不等。 Depending upon the particular formulation and the curing temperature, the curing time can be from about 1 minute to about 24 hours, from about 5 minutes to about 20 hours, about 10 minutes to about 15 hours, about 15 minutes to about 10 hours, or from about 30 minutes to about 5 hours vary. 根据某些实施方案,熟化时间为约15分钟至约30分钟不等。 According to certain embodiments the curing time varies from about 15 minutes to about 30 minutes. 根据其中熟化温度为至少约60°C、至少约62°C、至少约68°C、至少约70°C、至少约72°C或至少约75°C 或者从约62°C至约85°C或从约65°C至约85°C变化的另一些实施方案中,熟化时间优选地为至少约15分钟、至少约30分钟、至少约60分钟、至少约75分钟、至少约90分钟或至少约120分钟。 According wherein the curing temperature is at least about 60 ° C, at least about 62 ° C, at least about 68 ° C, at least about 70 ° C, at least about 72 ° C or at least about 75 ° C or from about 62 ° C to about 85 ° C or from about 65 ° C to about 85 ° C change in other embodiments, the curing time is preferably at least about 15 minutes, at least about 30 minutes, at least about 60 minutes, at least about 75 minutes, at least about 90 minutes, or at least about 120 minutes. 在其中熟化温度为例如至少约62°C、至少约68°C、至少约70°C、至少约72°C 或至少约75°C或者为约62°C至约80°C、约65°C至约80°C、约68°C至约80°C、约70°C至约80°C或约72°C至约80°C的一些优选实施方案中,熟化时间优选地为至少约1分钟、至少约5分钟、至少约10分钟、至少约15分钟或至少约30分钟。 Wherein the curing temperature is for example at least about 62 ° C, at least about 68 ° C, at least about 70 ° C, at least about 72 ° C or at least about 75 ° C or about 62 ° C to about 80 ° C, about 65 ° C to about 80 ° C, about 68 ° C to about 80 ° C, about 70 ° C and about 80 ° C or about 72 ° C to some preferred embodiments from about to 80 ° C, the curing time is preferably at least about 1 minute, at least about 5 minutes, at least about 10 minutes, at least about 15 minutes or at least about 30 minutes. 在某些这样的实施方案中,可选择熟化时间使得其尽可能短,同时还实现期望的结果(例如,提高的抗篡改)。 In some such embodiments, the curing time be selected so that it is as short as possible, while still achieving the desired result (e.g., improved tamper resistant). 例如,熟化时间优选地不超过约5小时,不超过约3小时或不超过约2小时。 For example, the curing time preferably does not exceed about 5 hours, no more than about 3 hours, or no more than about 2 hours. 优选地,熟化时间为约1分钟至约5小时、约5分钟至约3小时、约15分钟至约2小时或约15分钟至约1小时。 Preferably, the curing time is about 1 minute to about 5 hours, from about 5 minutes to about 3 hours, about 15 minutes to about 2 hours, or from about 15 minutes to about 1 hour. 本文中公开的熟化温度和熟化时间的任何组合均落在本发明的范围内。 Disclosed herein, any combination of curing temperature and curing time are within the scope of the present invention.

[0187] 在某些实施方案中,组合物仅在制剂中存在的聚环氧乙烷已经达到其软化温度和/或至少部分地熔化时才经受熟化温度。 [0187] In certain embodiments, the composition is only present in the polyethylene oxide formulation has reached its softening temperature and / or melt at least partially when subjected to the curing temperature. 在某些这样的实施方案中,熟化时间可小于约5分钟,例如熟化时间可为大于〇分钟至约3小时、约1分钟至约2小时或约2分钟至约1小时。 In some such embodiments, the curing time may be less than about 5 minutes, for example the curing time may be greater than the square minutes to about 3 hours, about 1 minute to about 2 hours or from about 2 minutes to about 1 hour. 通过选择能将制剂中的聚环氧乙烷立即加热到至少其软化温度使得高分子量聚环氧乙烷至少部分地熔化的熟化装置,可进行即时熟化。 By selecting heating the formulation can immediately polyethylene oxide to at least its softening temperature such that the high molecular weight polyethylene oxide at least partially melts curing means may be made instantly curing. 这样的熟化装置是例如微波炉、超声装置、 光辐照装置(例如UV辐照装置)、超高频(UHF)场或本领域技术人员公知的任何其他装置。 Such curing devices are for example microwave ovens, ultrasound devices, light irradiation apparatus (e.g., UV irradiation device), any other means ultra-high frequency (UHF) fields or known to those skilled in the art.

[0188] 制剂的大小可决定实现期望的抗篡改所需的熟化时间和熟化温度。 [0188] The size of the formulation may be determined to achieve the desired tamper resistance required curing time and curing temperature.

[0189] 在某些实施方案中,熟化步骤导致制剂的密度降低,使得经熟化制剂的密度低于进行熟化步骤之前的制剂的密度。 [0189] In certain embodiments, the curing step results in decreasing the density of the formulation, such that the density after curing is lower than the density of the formulation prior to the curing step formulation. 优选地,熟化的制剂的密度与未熟化的制剂的密度相比降低至少约0. 5%。 Preferably, the density density cured and uncured formulations formulation decreases by at least about 0.5% compared. 更优选地,熟化的制剂的密度与未熟化的制剂的密度相比降低至少约0. 7%、至少约0. 8%、至少约1. 0%、至少约2. 0%或至少约2. 5%。 More preferably, the density of the uncured formulation and the density of the cured formulation is reduced compared with at least about 0.7%, at least about 0.8%, at least about 1.0%, at least about 2.0%, or at least about 2 5%.

[0190] 在某些实施方案中,在至少聚环氧乙烷之软化点的温度下使固体控制释放剂型熟化至少1分钟、至少5分钟或至少15分钟。 [0190] In certain embodiments, the solid controlled release dosage form was aged for at least 1 minute, at least 5 minutes or at least 15 minutes at least the softening point of polyethylene oxide of temperature.

[0191] 在另一些实施方案中,在至少聚环氧乙烷之软化点的温度下使固体控制释放剂型熟化约1分钟至约48小时、约5分钟至约24小时、约15分钟至约1小时或约30分钟。 [0191] In other embodiments, so that at least the softening point of polyethylene oxide of the curing temperature of the solid controlled release dosage form from about 1 minute to about 48 hours, from about 5 minutes to about 24 hours, about 15 minutes to about 1 hour, or about 30 minutes.

[0192] 可例如在至少约60°C、至少约65°C、至少约70°C、至少约75°C的温度下或在约72°C的温度下使固体控制释放剂型熟化。 [0192] may be, for example, at least about 60 ° C, at least about 65 ° C, at least about 70 ° C, at a temperature of at least about 75 ° C or aging the solid controlled release dosage form at a temperature of about 72 ° C.

[0193] 在一些替代实施方案中,可在约60°C至约90°C、约62°C至约72°C、约65°C至约85°C、约70°C至约80°C、约75°C至约80°C或约70°C至约75°C的温度下使固体控制释放剂型熟化。 [0193] In alternative embodiments, it may range from about 60 ° C to about 90 ° C, about 62 ° C to about 72 ° C, about 65 ° C to about 85 ° C, about 70 ° C and about 80 ° C, about 75 ° C to about 80 ° C or about 70 ° C and at a temperature of about 75 ° C the solid was aged controlled release dosage form.

[0194] 压扁操作 [0194] flattening operation

[0195] 在某些实施方案中,本发明的剂型可被压扁而基本不损害活性剂的释放或剂型的完整性。 [0195] In certain embodiments, the dosage form of the present invention may be flattened without substantially compromising the integrity of the dosage form or release of the active agent. 与非被压扁形状之最小直径的厚度相比,扁平是针对被压扁形状之最小直径的厚度的描述。 The thickness of the smallest diameter of the non flattened shape compared to the thickness of the flat is a description of the smallest diameter of the flattened shape. 基于(i)当初始形状为非球形时未被压扁形状之最小直径的厚度,或(ii)当初始形状为球形时直径的厚度,该比较表示为厚度%。 Based on the minimum diameter (i) non-spherical shape when the initial shape of the non flattened thickness, or (ii) when the initial shape is spherical diameter, thickness, thickness of the comparison indicates%. 使用测厚仪(例如,数字测厚仪或数字卡尺)测量厚度。 Using thickness gauge (e.g., digital thickness gauge or digital caliper) thickness. 可通过任何可能的方法施加压扁力。 Flattening force may be applied by any possible method. 就测试本发明剂型的目的而言,可使用carver型台式压机(除非另外指明)从而实现目标压扁度/降低的厚度。 For purposes of testing dosage forms of the present invention, may be used type carver bench press (unless otherwise indicated) so as to achieve the target degree of flattening / reduced thickness. 根据本发明的某些实施方案,压扁不导致剂型破碎成碎块;但是可能出现边缘裂缝和开裂。 According to certain embodiments of the invention, the flattening does not result in a dosage form broken into pieces; however, edge cracking and fracture may occur.

[0196] 在本发明的某些实施方案中,可将锤子用于压扁剂型。 [0196] In certain embodiments of the invention, the hammer can be used for flattening dosage forms. 在这样的压扁方法中,从与剂型之最厚尺寸基本垂直的方向上手动地施加锤击。 In such a flattening process applied to the hammer from the dosage form with the thickest dimension substantially perpendicular to a direction manually. 之后如上文公开的相同方式描述扁度。 After the same manner as disclosed above described flat degrees.

[0197] 在另一些实施方案中,可使用Schleuniger设备相对于如Remington ' s Pharmaceutical Sciences,第18 版,1990 年,第89 章"Oral Solid Dosage Forms" 第1633-1665页中描述的破碎强度(breaking strength)或硬度测试来测量压扁。 [0197] In other embodiments, the apparatus may be used with respect to Schleuniger as Remington 's Pharmaceutical Sciences, 18th Edition, 1990, Chapter 89 "Oral Solid Dosage Forms" breaking strength page 1633-1665 described in ( breaking strength) and hardness test to measure compressed. 在这样的一个实施方案中,在平行排列的一对平板之间挤压剂型,使得从与剂型之最厚尺寸基本垂直的方向上施加力,从而压扁剂型。 In such an embodiment, the dosage form pressing between a pair of parallel plates arranged such that a force is applied from the dosage form with the thickest dimension substantially perpendicular direction, thereby flattening the dosage form. 根据基于进行破碎强度测试之前被压扁的尺寸之厚度, 可以以术语压扁%来描述剂型的压扁。 The thickness prior to breaking strength test based on the dimensions of the flattened, the term may be flattened% flattening described dosage form. 将破碎强度(或硬度)定义为使所测试剂型破碎时的力。 The crushing strength (or hardness) defined as the force at the tested dosage broken. 不破碎但由于所施加的力而变形的剂型被认为在此特定的力下是抗破碎的。 However, not broken due to the force applied by the deformed dosage form is considered in this particular anti-crushing force.

[0198] 定量剂型强度的另一种测试是使用质构仪(Texture Analyzer)如TA-XT2质构仪(Texture Technologies Corp.,18Fairview Road,Scarsdale,NY 10583)的压痕试验(indentation test)。 [0198] Another test is to quantify the strength of the dosage form using a texture analyzer (Texture Analyzer) The TA-XT2 Texture Analyzer (Texture Technologies Corp., 18Fairview Road, Scarsdale, NY 10583) of the indentation test (indentation test). 在该方法中,将剂型置于具有轻微凹面的不锈钢支架顶部,然后通过质构仪的下行探针刺入,例如TA-8A的1/8英寸直径的不锈钢球形探针。 In this process, the dosage form is placed a stainless steel stent with a slightly concave top, then piercing by the descending probe of the Texture Analyzer, such as 1/8 inch diameter stainless steel ball probe of TA-8A. 开始测量之前,使剂型直接对准在探针下,使得下行探针将中心性地刺入片剂中(即剂型的中央),并且使得从与剂型之直径基本上垂直并且与其厚度基本上成一直线的方向上施加下行探针的力。 Before starting the measurement, the dosage form so aligned directly under the probe, such that the descending probe will penetrate the center of the tablet (i.e. the center of the dosage form), and so that the diameter from the dosage form and its thickness is substantially perpendicular to a substantially force of the descending probe is applied to the linear direction. 首先,开始以测试前速度使质构仪的探针移向剂型样品。 First, before beginning to test the speed of the probe toward the sample dosage Texture Analyzer. 当探针与剂型表面相接触时,达到所设定的触发力,探针继续以测试速度移动并且刺入剂型。 When the probe is in contact with the surface of the dosage form, reaches the set trigger force, the probe continues to test the speed of the moving and puncturing dosage form. 对于探针的每个刺入深度或距离,测量对应的力。 For each penetration depth or distance of the probe, measuring the corresponding forces. 当探针已经达到所期望的最大刺入深度时,其改变方向并且以测试后速度往回移动,同时进一步采集测量值。 When the probe has reached the desired maximum penetration depth, it changes direction and moves back at the test speed, while further measured values ​​are acquired. 将开裂力(cracking force)定义为在相应的力/ 距离图中达到的第一局部最大的力,并且使用例如质构仪软件"Texture Expert Exceed, Version 2.64English"进行计算。 The force cracking (cracking force) defined as the first local maximum force reached in the corresponding force / distance map, and for example the Texture Analyzer software "Texture Expert Exceed, Version 2.64English" is calculated.

[0199] 对于本发明某些实施方案的目的而言,将术语"抗压碎"定义为指可采用上述台式压机将其至少压扁为下述厚度而不破碎的剂型:不超过约60%厚度、优选不超过约50%厚度、更优选不超过约40 %厚度、甚至更优选不超过约30 %厚度并且最优选不超过约20 %厚度、10%厚度或5%厚度。 [0199] For the purposes of certain embodiments of the present invention, the term "resistant to crushing" is defined above may be used to refer to a bench press to a thickness of flattened without breaking at least the following dosage form: not more than about 60 % of the thickness, preferably no more than about 50% thickness, preferably no more than about 40% thickness, even more preferably no more than about 30% thickness and most preferably no more than about 20% thickness, 10% thickness or 5% of the thickness.

[0200] 在某些实施方案中,如通过在USP装置1(篮)中以IOOrpm在37°C下于900ml不含酶的模拟胃液(SGF)中体外溶出所测量的,在0. 5小时时从被压扁剂型释放的活性剂(例如,阿片样镇痛剂)的量与在〇. 5小时时从未被压扁剂型释放的量相比偏差不超过约10% 点、15%点或20%点。 [0200] In certain embodiments, such as by the USP Apparatus 1 (basket) at IOOrpm at 37 ° C for 900ml simulated gastric fluid without enzymes (SGF) as measured in vitro dissolution, in 0.5 hours when released from the dosage form flattened active agent (e.g., opioid analgesic) amount when compared to the amount billion. 5 hours flattened dosage form releases never deviates no more than about 10% points, 15 points or 20% of the points.

[0201] 在一些替代实施方案中,固体控制释放剂型可被压扁而不破碎,其中被压扁后剂型的厚度相当于被压扁前剂型厚度的不超过约60%,被压扁前剂型厚度的不超过约50%, 被压扁前剂型厚度的约不超过40%,被压扁前剂型厚度的不超过约30%或被压扁前剂型厚度的不超过约20%。 [0201] In alternative embodiments, the solid controlled release dosage form can be flattened without breaking, wherein the dosage form after the flattening which corresponds to the thickness of the dosage form before flattening thickness no more than about 60% of the dosage form before flattening the thickness of no more than about 50%, the dosage form before flattening a thickness of about not more than 40%, is not more than about 30% of the thickness before flattening dosage or dosage form before flattening a thickness no more than about 20%.

[0202] 阐述以下实施例用于帮助理解本发明而不应被理解为具体地限制本文中描述的和要求保护的本发明。 [0202] The following examples are set forth to assist in understanding the present invention and should not be construed as specifically limiting the invention described herein and claimed. 认为可在本领域技术人员视界内的这样的本发明变化形式(包括现在已知或随后发展的所有等同物的替代)以及制剂的变化或实验设计的最小变化落在本文中并入的本发明的范围内。 Variations of the invention may be considered within the purview of one skilled in this art (including all equivalents, alternatives now known or later developed) and minimum variations or changes in experimental design, fall within the invention formulations herein incorporated In the range.

[0203] 实施例 [0203] Example

[0204] 现在参照所附的实施例更全面地描述本发明。 [0204] Embodiment Referring now to the accompanying present invention will be described more fully. 然而,应理解,以下说明仅是举例说明性的,而不应以任何方式视为对本发明的限制。 However, it should be understood that the following description is illustrative only, and should in no way be considered as limiting the present invention.

[0205] 实施例1 [0205] Example 1

[0206] 使用高分子量聚环氧乙烷(PEO 303-MW 7, 000, 000)制备了包含20mg重酒石酸氢可酮的400mg片剂(片剂A),如以下表1所示。 [0206] high molecular weight polyethylene oxide 400mg tablets (Tablet A) comprises 20mg of hydrocodone bitartrate (PEO 303-MW 7, 000, 000) were prepared as shown in Table 1.

[0207] 表1 (片剂A) [0207] Table 1 (Tablet A)

[0208] [0208]

Figure CN104856967AD00271

[0209] 为了制备核心,将Manesty F3 型单站压片机(single station Manesty Type F 3tablet press)配置7.94mm圆形标准凹面工具(concave plain tooling)。 [0209] To prepare the core, a Manesty F3 single station tablet press (single station Manesty Type F 3tablet press) round, standard concave plain tooling configuration 7.94mm (concave plain tooling). 如上文表1 中所示,称出200mg的目标重量的粉末状核心共混物的等量份,装入冲模,然后压制以形成片剂A的核心。 As shown in Table 1 above, it was weighed out powdered aliquot of the core blend target weight of 200mg, charged into the die and then compressed to form the core of the tablet A.

[0210] 为了制备壳,将Manesty F3型单站压片机配置10. 32mm圆形标准凹面工具。 [0210] To prepare the shell, single station Manesty F3 type tabletting machine 10. 32mm round standard concave configuration tool. 将如表1所示IOOmg壳共混物装入冲模中。 The case shown in Table 1 blend IOOmg loaded die. 将上述制备的片剂核心手动地集中在冲模中心(在粉末床的顶部),将另外的IOOmg壳共混物置于冲模中片剂的顶部。 The tablet cores prepared above was manually centered in the die (on top of the powder bed), an additional shell IOOmg blend was placed on top of the tablet in the die. 之后通过旋转压轮手动地压制材料以形成压制包衣片剂A。 After passing through the rotating pressure wheel manually pressed material to form the press-coated tablets A.

[0211] 将上所述制备的数个压制包衣片剂A片剂放置在置于目标温度为72°C的Hotpack 435304型烘箱中的托盘上30分钟以熟化。 [0211] The number of pressing the prepared coated tablets A tablet was placed on a target placed Hotpack 435304 type oven temperature 72 ° C in 30 minutes to cure the tray.

[0212] 之后在USP装置1(篮)中以IOOrpm在37°C下于900ml不含酶的模拟胃液(SGF) 中测试经熟化的片剂A片剂的溶出。 After [0212] In IOOrpm in 900ml of simulated gastric fluid without enzymes (SGF) Tablet A tablet was tested it is cured at 37 ° C for dissolution in a USP Apparatus 1 (basket). 图1中针对实施例2~4之制剂的结果示出结果。 The results in FIG. 1 for the preparation of Examples 2 to 4 show the results.

[0213] 实施例2 [0213] Example 2

[0214] 使用高分子量聚环氧乙烷(PEO 303-MW 7, 000, 000)制备了包含20mg重酒石酸氢可酮的500mg片剂(片剂B),如以下表2所示。 [0214] high molecular weight polyethylene oxide 500mg tablets (Tablet B) contains 20mg of hydrocodone bitartrate (PEO 303-MW 7, 000, 000) were prepared as shown below in Table 2.

[0215] 表2 (片剂B) [0215] Table 2 (Tablet B)

[0216] [0216]

Figure CN104856967AD00281

[0217] 为了制备核心,将Manesty F3型单站压片机配置8. 73mm圆形标准凹面工具。 [0217] To prepare the core, a Manesty F3 single station tablet press 8. 73mm round standard concave configuration tool. 如上文表2所示,称出300mg的目标重量的粉末状核心共混物的等量份,装入冲模,然后压制以形成片剂B的核心。 As shown in Table 2, an aliquot of said powder blend core target weight of 300mg, charged into the die and then compressed to form the core of the tablet B.

[0218] 为了制备壳,将Manesty F3型单站压片机配置11. Ilmm圆形标准凹面工具。 [0218] To prepare the shell, single station Manesty F3 type tabletting machine 11. Ilmm arranged round standard concave plain tooling. 如表2所示,将200mg壳共混物的第一部分置于冲模中。 As shown in Table 2, the first housing part 200mg blend placed in the die. 将上述制备的片剂核心手动地集中在冲模中心(在粉末床的顶部),将200mg壳共混物的剩余部分置于冲模中片剂的顶部。 The tablet cores prepared above was manually centered in the die (on top of the powder bed), the remaining portion of the shell 200mg blend was placed on top of the tablet in the die. 之后通过旋转压轮手动地压制材料以形成压制包衣片剂B。 After passing through the rotating pressure wheel manually pressed material to form the press-coated tablets B.

[0219] 将如上所述制备的数个压制包衣片剂B片剂放置在置于目标温度为72°C的Hotpack 435304型烘箱中的托盘上30分钟以熟化。 The [0219] prepared as described above a number of press-coated tablet is placed in a Hotpack 435304 B tablets placed in the target type oven temperature of 72 ° C in 30 minutes to cure the tray.

[0220] 之后在USP装置1 (篮)中以IOOrpm在37°C下于900ml不含酶的模拟胃液(SGF) 中测试经熟化的片剂B片剂的溶出。 After [0220] In IOOrpm in 900ml of simulated gastric fluid without enzymes (SGF) was tested tablet Tablet B is cured at 37 ° C for dissolution in a USP Apparatus 1 (basket). 图1中针对实施例1和3~4之制剂的结果示出结果。 FIG. 1 and the results of Examples 1 to 4 of formulation 3 shows the results.

[0221] 实施例3 [0221] Example 3

[0222] 使用高分子量聚环氧乙烷(PEO 303-MW 7, 000, 000)制备了含有20mg重酒石酸氢可酮的500mg片剂(片剂C),如以下表3所示。 [0222] high molecular weight polyethylene oxide 500mg tablet (tablet C) contains 20mg of hydrocodone bitartrate (PEO 303-MW 7, 000, 000) were prepared as shown below in Table 3.

[0223] 表3 (片剂C) [0223] Table 3 (tablet C)

[0224] [0224]

Figure CN104856967AD00291

[0225] 为了制备核心,将Manesty F3型单站压片机配置9. 53mm圆形标准凹面工具。 [0225] To prepare the core, a Manesty F3 single station tablet press 9. 53mm round standard concave configuration tool. 如上文表3所示,称出300mg的目标重量的粉末状核心共混物的等量份,装入冲模,然后压制以形成片剂C的核心。 As shown in Table 3, an aliquot of said powder blend core target weight of 300mg, charged into the die and then compressed to form the core tablet C.

[0226] 为了制备壳,将Manesty F3型单站压片机配置11. Ilmm圆形标准凹面工具。 [0226] To prepare the shell, single station Manesty F3 type tabletting machine 11. Ilmm arranged round standard concave plain tooling. 如表3所示,将200mg壳共混物的第一部分置于冲模中。 As shown in Table 3, the first housing part 200mg blend placed in the die. 将上述制备的片剂核心手动地集中在冲模中心(在粉末床的顶部),将200mg壳共混物的剩余部分置于冲模中片剂的顶部。 The tablet cores prepared above was manually centered in the die (on top of the powder bed), the remaining portion of the shell 200mg blend was placed on top of the tablet in the die. 之后通过旋转压轮手动地压制材料以形成压制包衣片剂C。 After passing through the rotating pressure wheel manually pressed material to form the press-coated tablets C.

[0227] 将如上所述制备的数个压制包衣片剂C片剂放置在置于目标温度为72°C的Hotpack 435304型烘箱中的托盘上30分钟以熟化。 The [0227] prepared as described above a number of press-coated tablet is placed in a Hotpack 435304 C tablets placed in the target type oven temperature of 72 ° C in 30 minutes to cure the tray.

[0228] 之后在USP装置1(篮)中以IOOrpm在37°C下于900ml不含酶的模拟胃液(SGF) 中测试经熟化的片剂C片剂的溶出。 After [0228] In IOOrpm in 900ml of simulated gastric fluid without enzymes (SGF) C tablets was tested Dissolution of the tablets were cured at 37 ° C for in a USP Apparatus 1 (basket). 图1中针对实施例1~2和4之制剂的结果示出结果。 Results in FIG. 1 for the preparation of Examples 1 and 2 and 4 shows the results of the embodiment.

[0229] 实施例4 [0229] Example 4

[0230] 使用高分子量聚环氧乙烷(PEO 303-MW 7, 000, 000)制备了包含20mg重酒石酸氢可酮的475mg片剂(片剂D),如以下表4所示。 [0230] high molecular weight polyethylene oxide 475mg tablets (Tablet D) contains 20mg of hydrocodone bitartrate (PEO 303-MW 7, 000, 000) were prepared as shown below in Table 4.

[0231] 表4 (片剂D) [0231] Table 4 (Tablet D)

[0232] [0232]

Figure CN104856967AD00292

[0233] 为了制备核心,将Manesty F3型单站压片机配置7. 94mm圆形标准凹面工具。 [0233] To prepare the core, a Manesty F3 single station tablet press 7. 94mm round standard concave configuration tool. 如上文表4所示,称出175mg的目标重量的粉末状核心共混物的等量份,装入冲模,然后压制以形成片剂D的核心。 As shown in Table 4, an aliquot of said powder blend core target weight of 175mg, charged into the die and then compressed to form the core of the tablet D.

[0234] 为了制备壳,将Manesty F3型单站压片机配置11. Ilmm圆形标准凹面工具。 [0234] To prepare the shell, single station Manesty F3 type tabletting machine 11. Ilmm arranged round standard concave plain tooling. 如表4所示,将300mg壳共混物的第一部分置于冲模中。 As shown in Table 4, the first housing part 300mg blend placed in the die. 将上述制备的片剂核心手动地集中在冲模中心(在粉末床的顶部),将300mg壳共混物的剩余部分置于冲模中片剂的顶部。 The tablet cores prepared above was manually centered in the die (on top of the powder bed), the remaining portion of the shell 300mg blend was placed on top of the tablet in the die. 之后通过旋转压轮手动地压制材料以形成压制包衣片剂D。 After passing through the rotating pressure wheel manually pressed material to form the press-coated tablets D.

[0235] 之后将如上所述制备的数个压制包衣片剂D片剂放置在置于目标温度为72°C的Hotpack 435304型烘箱中的托盘上30分钟以熟化。 After the [0235] prepared as described above a number of press-coated tablet is placed in a Hotpack 435304 D-type tablets placed in an oven at a target temperature of 72 ° C in 30 minutes to cure the tray.

[0236] 之后在USP装置1(篮)中以IOOrpm在37°C下于900ml不含酶的模拟胃液(SGF) 中测试经熟化的片剂D片剂的溶出。 After [0236] In IOOrpm in 900ml of simulated gastric fluid without enzymes (SGF) Tablet D was tested Dissolution of the tablets were cured at 37 ° C for in a USP Apparatus 1 (basket). 图1中针对实施例1~3之制剂的结果示出结果。 The results in FIG. 1 for the preparation of Examples 1 to 3 shows the results.

[0237] 实施例5 [0237] Example 5

[0238] 将低分子量聚环氧乙烷(PEO 205-MW 600,000)用于核心并且将高分子量聚环氧乙烷(PEO 303-MW 7,000,000)用于壳来制备含有120mg氢可酮的500mg片剂(片剂E),如以下表5所示。 [0238] The low molecular weight polyethylene oxide (PEO 205-MW 600,000) for the core and the high molecular weight polyethylene oxide (PEO 303-MW 7,000,000) for the shell was prepared containing 120mg 500mg tablets of hydrocodone agent (tablets E), as shown in table 5 below.

[0239] 表5 (片剂E) [0239] Table 5 (Tablet E)

[0240] [0240]

Figure CN104856967AD00301

[0241] 为了制备核心,将Manesty F3型单站压片机配置8. 73mm圆形标准凹面工具。 [0241] To prepare the core, a Manesty F3 single station tablet press 8. 73mm round standard concave configuration tool. 如上文表5所示,称出300mg的目标重量的粉末状核心共混物的等量份,装入冲模,然后压制以形成片剂E的核心。 As shown in Table 5 above, was weighed out powdered aliquot of the core blend target weight of 300mg, charged into the die and then compressed to form a tablet core of E.

[0242] 为了制备壳,将Manesty F3型单站压片机配置11. Ilmm圆形标准凹面工具。 [0242] To prepare the shell, single station Manesty F3 type tabletting machine 11. Ilmm arranged round standard concave plain tooling. 如表5所示,将200mg壳共混物的第一部分置于冲模中。 As shown in Table 5, the first housing part 200mg blend placed in the die. 将上述制备的片剂核心手动地集中在冲模中心(在粉末床的顶部),将200mg壳共混物的剩余部分置于冲模中片剂的顶部。 The tablet cores prepared above was manually centered in the die (on top of the powder bed), the remaining portion of the shell 200mg blend was placed on top of the tablet in the die. 通过旋转压轮手动地压制材料以形成压制包衣片剂E。 By rotating the pinch roller pressing the material to form a manually press-coated tablets E.

[0243] 之后将如上所述制备的数个压制包衣片剂E片剂放置在置于目标温度为72°C的Hotpack 435304型烘箱中的托盘上30分钟以熟化。 After the [0243] prepared as described above a number of press-coated tablet is placed in a Hotpack 435304 E tablet placed in the target type oven temperature 72 ° C in 30 minutes to cure the tray.

[0244] 之后在USP装置1 (篮)中以IOOrpm在37°C下于900ml不含酶的模拟胃液(SGF) 中测试经熟化的片剂E片剂的溶出。 After [0244] In IOOrpm in 900ml of simulated gastric fluid without enzymes (SGF) Cured tablets were tested by the E tablets at 37 ° C for dissolution in a USP Apparatus 1 (basket). 图2中针对实施例5和6之制剂的结果示出结果。 FIG 2 Results for Formulation Examples 5 and 6 shows the results of the embodiment.

[0245] 实施例6 [0245] Example 6

[0246] 使用高分子量聚环氧乙烷(PEO 303-MW 7,000,000)制备了含有120mg氢可酮的500mg片剂(片剂F),如以下表6所示。 [0246] high molecular weight polyethylene oxide (PEO 303-MW 7,000,000) the 500mg tablets (Tablet F) containing 120mg hydrocodone prepared as shown below in Table 6.

[0247] 表6 (片剂F) [0247] Table 6 (Tablet F)

[0248] [0248]

Figure CN104856967AD00302

[0249] 为了制备核心,将Manesty F3型单站压片机配置8. 73mm圆形标准凹面工具。 [0249] To prepare the core, a Manesty F3 single station tablet press 8. 73mm round standard concave configuration tool. 如上文表6所示,称出300mg的目标重量的粉末状核心共混物的等份量,装入冲模,然后压制以形成片剂F的核心。 As shown in Table 6, aliquots weighed out powdered blend core target weight of 300mg, charged into the die and then compressed to form the core of the tablet F.

[0250] 为了制备壳,将Manesty F3型单站压片机配置11. Ilmm圆形标准凹面工具。 [0250] To prepare the shell, single station Manesty F3 type tabletting machine 11. Ilmm arranged round standard concave plain tooling. 如表6所示,将200mg壳共混物的第一部分置于冲模中。 As shown in Table 6, the blend of the first housing part 200mg placed in the die. 将上述制备的片剂核心手动地集中在冲模中心(在粉末床的顶部),将200mg壳共混物的剩余部分置于冲模中片剂的顶部。 The tablet cores prepared above was manually centered in the die (on top of the powder bed), the remaining portion of the shell 200mg blend was placed on top of the tablet in the die. 通过旋转压轮手动地压制材料以形成压制包衣片剂F。 By rotating the pinch roller pressing the material to form a manually press-coated tablets F.

[0251] 之后将如上所述制备的数个压制包衣片剂F片剂放置在置于目标温度为72°C的Hotpack 435304型烘箱中的托盘上30分钟以熟化。 After several press [0251] The tablets prepared as described above coated tablet was placed on the F-type oven Hotpack 435304 is placed in the target temperature of 72 ° C in 30 minutes to cure the tray.

[0252] 之后在USP装置1(篮)中以IOOrpm在37°C下于900ml不含酶的模拟胃液(SGF) 中测试片剂F片剂的溶出。 1 (basket) to IOOrpm F tablets The tablets were tested in at 37 ° C for 900ml simulated gastric fluid without enzymes (SGF) After dissolution USP apparatus [0252]. 图2中针对实施例5和6之制剂的结果示出结果。 FIG 2 Results for Formulation Examples 5 and 6 shows the results of the embodiment.

[0253] 实施例7~12 [0253] Examples 7 to 12

[0254] 根据以下表7(20mg)或表8(120mg)制备了包含20mg重酒石酸氢可酮(片剂G、 H和I)或120mg重酒石酸氢可酮(片剂J、K和L)的六种不同压制包衣片剂(称为片G~ L) 〇 [0254] According to the following Table. 7 (20mg) or Table. 8 (120mg) containing 20mg of hydrocodone bitartrate (Tablets G, H and I) or hydrocodone bitartrate 120mg (tablet J, K and L) Preparation of six different coated tablet (referred to as sheet G ~ L) square

[0255] 表7 (片剂G、H、I) [0255] Table 7 (Tablet G, H, I)

[0256] [0256]

Figure CN104856967AD00311

[0257] 表8 (片剂J、K、L) [0257] Table 8 (tablet J, K, L)

[0258] [0258]

Figure CN104856967AD00321

[0259] 用重酒石酸氢可酮、微晶纤维素和羟丙基纤维素填装高剪切制粒机(Collette 75L)。 [0259] by weight hydrocodone bitartrate, microcrystalline cellulose and hydroxypropyl cellulose filled high shear granulator (Collette 75L). 在桨和切碎机(chopper)打开的情况下将水添加至混合物中(例如,8~15% )。 In the case where the propeller and the chopper (Chopper) will open to the mixture was added water (e.g., 8 to 15%). 使湿颗粒通过Quadro Comil磨碎装置的粗筛。 The wet granules through a coarse screen Quadro Comil mill work. 将筛过的湿颗粒在Vector VFC-3流化床干燥器中进行干燥。 The wet sieved granules were dried in a Vector VFC-3 fluid bed dryer. 使干燥的颗粒通过Quadro Comil磨碎装置的细筛。 The dried granules were passed through a fine sieve Quadro Comil mill work.

[0260] 用PEO POLYOX WSR 205和磨碎的颗粒填装16Q "V"形共混机并共混5分钟。 [0260] with PEO POLYOX WSR 205 and ground particles of filled 16Q "V" shaped blender and blended for 5 minutes. 将筛过的硬脂酸镁添加至混合物中并共混1分钟以制备核心共混物。 The screened magnesium stearate was added to the mixture and blended for 1 minute to blend preparation of the core.

[0261] 用PEO POLYOX WSR 303、D&C红色No. 30铝色淀和磨碎的颗粒填装16Q "V"形共混机并共混5分钟。 [0261] with PEO POLYOX WSR 303, D & C Red No. 30 aluminum lake and ground particles packed 16Q "V" shaped blender and blended for 5 minutes. 将筛过的硬脂酸镁添加至混合物中并共混1分钟以制备干包衣共混物。 The screened magnesium stearate was added to the mixture and blended for one minute to prepare dry coated blend.

[0262] 采用DryCota压机将核心共混物和干包衣共混物压制成干包衣片剂。 [0262] The core press DryCota blend and the dry blend is compressed into a coating dry coated tablet. 将核心共混物加载至一侧料斗(hopper)中并将核心重量调节至目标300mg。 The blend was loaded to one side of the core hopper (Hopper) in the core and the weight adjusted to the target 300mg. 之后,将干包衣共混物加载至两侧料斗中并将总片剂重量调节至目标。 Thereafter, the dry blend was loaded to both sides of the coating hopper and adjusted to the target total tablet weight. 重量调节之后,开始压制运行并以例如6rpm 运行压机。 After adjusting the weight, start running and pressing the press operation, for example 6rpm.

[0263] 称量约IOkg压制包衣片剂并在多孔24英寸的Compu-Lab包衣锅中用欧巴代(Opadry)包衣悬液进行喷雾包衣至约1.0% (按重量计)的目标重量增长。 [0263] weighing about IOkg coated tablet and a porous spray-coating a 24 inch Compu-Lab coating pan with Opadry (Opadry) coating suspension to about 1.0% (by weight) target weight gain. 如下进行喷雾包衣。 As spray coating. 通过将入口空气温度设定至55°C来使片床升温。 By setting the inlet air temperature to 55 ° C to the sheet raised bed. 一旦排气口温度达到39°C,那么以12rpm的锅速和约44mL/分钟的喷雾速率开始膜包衣。 Once the exhaust temperature reached 39 ° C, then the pan speed to 12rpm spray rate of about 44mL / min film coating was started. 持续膜包衣直到实现目标重量增长1% (这在步骤X中熟化之前为部分包衣,因为在步骤xii中4%重量增长的最终包衣在熟化期间变得黏稠)。 Continued until a film coating target weight gain of 1% (before curing in step X is partially coated, as in step xii 4% weight gain of final coating becomes sticky during ripening).

[0264] 经部分包衣的片剂在多孔包衣锅中熟化。 [0264] curing the partially coated tablets in a perforated coating pan. 将入口空气温度设定为85°C,锅速设定为约lOrpm。 The inlet air temperature was set to 85 ° C, the pan speed was set to approximately lOrpm. 在72°C的排气口温度下将片剂熟化约30分钟。 In the exhaust temperature of 72 ° C tablets were cured for about 30 minutes.

[0265] 熟化后,在旋转的锅中通过将入口温度设定为22°C来使片剂冷却。 [0265] After aging, to make the rotating pan tablets cooled by the inlet temperature was set to 22 ° C. 持续冷却直到排气口温度低于28 °C。 Continuing cooling until the exhaust temperature is below 28 ° C.

[0266] 之后,在多孔包衣锅中以12rpm的锅速和约44mL/分钟的喷雾速率将经熟化的片剂用额外的包衣悬液喷雾包衣以得到4. 0%的目标最终重量增长(按重量计,包括之前的1%包衣在内)。 After [0266], in a perforated coating pan at a pan speed of about 12rpm 44mL / min spray rate of the coating with additional coating suspension was sprayed to give a cured tablets were 4.0% of the final target weight gain (by weight, 1% prior to the inner coating).

[0267] 将膜包衣片剂转移到配衡的(tared)聚乙烯内衬滚筒(drum)中。 [0267] The film-coated tablet was transferred to a tared (tared) polyethylene lined drum (Drum) In.

[0268] 对于这些压制包衣的20mg和120mg片剂而言,溶出结果(经时间释放活性物的% )在图3以及以下表9和10中示出。 [0268] For these press-coated tablets 20mg and 120mg, the results of the dissolution (% release of active over time) in FIG. 3 and the following Table 9 and 10 is shown.

[0269] [0269]

Figure CN104856967AD00331

[0270] 如上述实施例的溶出所示,影响活性剂从剂型溶出的因素是核心:壳重量比和片剂重量。 Factors [0270] As shown in the above embodiments dissolution effects of the active agent from the dosage form is dissolution of the core: shell weight ratio and the tablet weight. 另外,以上示出的溶出数据证明,本发明的制剂展现出如本文中公开的基本零级的释放。 Further, the dissolution data shown above demonstrate, the formulations of the present invention exhibit substantially zero order release as disclosed herein.

[0271] 实施例13 [0271] Example 13

[0272] 用实施例7~12的氢可酮制剂(HYD)进行健康成年男性和女性对象中的随机开放标签交叉研宄。 [0272] with hydrogen in Examples 7 to 12 may be one formulation (HYD) randomized, open-label healthy adult male and female subjects in the crossover study based. 该研宄由迭代(Iteration)(每次用经历一组预定治疗的独特对象组重复研宄设计的方法)构成。 The study based (Method study based on design experience with each repetition of a set of predetermined unique object treated group) by the iteration (the Iteration) configuration. 进行以下迭代: The following iterations:

[0273] 诛代1 : [0273] Generation punish 1:

[0274] N = 36 [0274] N = 36

[0275] 随机、单次剂量、3种治疗、3阶段交叉。 [0275] A randomized, single dose, 3 treatments, cross-phase 3.

[0276] · HYD 20mg,慢速释放片剂,禁食状态(片剂G) [0276] · HYD 20mg, slow release tablet, fasted state (Tablet G)

[0277] · HYD 20mg,中速释放片剂,禁食状态(片剂H) [0277] · HYD 20mg, medium release tablet, fasted state (Tablet H)

[0278] · HYD 20mg,快速释放片剂,禁食状态(片剂I) [0278] · HYD 20mg, rapid release tablet, fasted state (Tablet I)

[0279] 诛代2 : [0279] Generation punish 2:

[0280] N = 36 [0280] N = 36

[0281] 随机、单次剂量、3种治疗、3阶段交叉。 [0281] A randomized, single dose, 3 treatments, cross-phase 3.

[0282] · HYD 120mg,慢速释放片剂,禁食状态(片剂J) [0282] · HYD 120mg, slow release tablet, fasted state (Tablet J)

[0283] · HYD 120mg,中速释放片剂,禁食状态(片剂K) [0283] · HYD 120mg, medium release tablet, fasted state (Tablet K)

[0284] · HYD 120mg,快速释放片剂,禁食状态(片剂L) [0284] · HYD 120mg, rapid release tablet, fasted state (Tablet L)

[0285] 诛代3 : [0285] Generation punish 3:

[0286] N = 16 [0286] N = 16

[0287] 随机、单次剂量、2种治疗、2阶段交叉。 [0287] A randomized, single-dose, two kinds of treatment, two-period crossover.

[0288] · HYD 120mg,慢速释放片剂,禁食状态(片剂J) [0288] · HYD 120mg, slow release tablet, fasted state (Tablet J)

[0289] · HYD 120mg,慢速释放片剂,进食状态(片剂J) [0289] · HYD 120mg, slow release tablet, fed state (Tablet J)

[0290] 在如所指定的禁食或进食状态下,将制剂各自单次剂量用8盎斯(oz. ) (240mL)水口服施用。 [0290] As specified in the fasted or fed state, each with a single dose formulation 8 ounces (oz.) (240mL) water for oral administration.

[0291] 因为该研宄是在健康人对象中进行的,施用阿片样拮抗剂纳曲酮盐酸盐以将与阿片样物质相关的不良事件降至最低。 [0291] Since this study based was conducted in healthy human subjects, the administration of the opioid antagonist naltrexone hydrochloride adverse events associated with the opioid to a minimum.

[0292] 筛选流程 [0292] screening process

[0293] 在施用首次剂量之前28天内进行的筛选访视(screening visit)时对所有可能的对象进行下述筛选流程: [0293] screening visit within 28 days were subjected to the following screening process for all possible objects prior to administration of the first dose (screening visit):

[0294] -知情同意。 [0294] - informed consent.

[0295] -任选药物基因组采样的知情同意。 [0295] - optionally pharmacogenomic samples informed consent.

[0296] -任选毛发采样的知情同意。 [0296] - optionally a hair sample informed consent.

[0297] -体重、身高、身体质量指数(BMI)和人口统计学数据。 [0297] - weight, height, body mass index (BMI), and demographic data.

[0298] -纳入/排除标准的评价。 [0298] - inclusion / exclusion criteria evaluation.

[0299] -病史和用药史,包括伴随用药。 [0299] - medical and medication history, including concomitant medication.

[0300] -坐下约5分钟之后的生命体征(收缩/舒张血压、脉搏率、呼吸速率、口腔温度) 和SpO2。 [0300] - after vital signs sit for about 5 minutes (systolic / diastolic blood pressure, pulse rate, respiratory rate, oral temperature) and SpO2.

[0301] -站立约2分钟之后的另一些生命体征(收缩/舒张血压和脉搏率)。 [0301] - stand other vital signs (systolic / diastolic blood pressure and pulse rate) after about 2 minutes.

[0302] -HDYF ?在测量生命体征的同时进行询问。 [0302] -HDYF? Interrogated in the measurement of vital signs at the same time.

[0303] -常规体检。 [0303] - routine physical examination.

[0304] -至少4小时禁食后的临床实验室评价(包括生物化学、血液学和尿分析)。 [0304] - Clinical laboratory evaluations at least 4 hours after fasting (including biochemistry, hematology, and urinalysis).

[0305] -12导联心电图(ECG)。 [0305] -12-lead electrocardiogram (ECG). QTcF不超过450晕秒(msec)。 Halo QTcF does not exceed 450 seconds (msec).

[0306] -肝炎筛查(包括乙型肝炎表面抗原[HBsAg]、丙型肝炎抗体[抗HCV])。 [0306] - Screening hepatitis (including hepatitis B surface antigen [HBsAg], hepatitis C antibody [anti-HCV]).

[0307] -酒精、可替宁(cotinine)和所选滥用药物的筛查。 [0307] - alcohol and cotinine (cotinine), and selected drugs of abuse screening.

[0308] -血清妊娠测试,仅女性对象;血清促卵泡刺激激素(FSH),仅绝经后女性。 [0308] - serum pregnancy test, females only objects; serum follicle stimulating hormone (FSH), postmenopausal females only.

[0309] -血清妊娠测试(仅女性对象)。 [0309] - serum pregnancy test (female subjects only).

[0310] -血清卵泡刺激素(FSH)测试(仅绝经后女性) [0310] - serum follicle stimulating hormone (FSH) test (postmenopausal females only)

[0311] 纳入标准 [0311] inclusion criteria

[0312] -符合下述标准的对象被纳入到本研宄中。 [0312] - Object met the following criteria were included in the study based on this.

[0313] -提供书面知情同意。 [0313] - providing written informed consent.

[0314] -年龄在18至50岁(包括端值)的男性和女性。 [0314] - men and women aged 18-50 years of age (inclusive) of.

[0315] -体重在50 至IOOkg(IK)至220 镑(Ib))并且BMI 在18 至34(kg/m2)(包括端值)。 [0315] - weighing 50 to IOOkg (IK) to 220 pounds (Ib)) and a BMI of 18 to 34 (kg / m2) (inclusive).

[0316] -病史、体检、生命体征和ECG确认为健康并且无显著异常发现。 [0316] - medical history, physical examination, vital signs and ECG recognized as healthy and free of significant abnormal findings.

[0317] -育龄女性必须使用充分且可靠的避孕法(例如含有另外的杀精子剂泡沫剂或胶冻剂的屏障、宫内避孕器、激素避孕)。 [0317] - Women of childbearing age must be adequate and reliable method of contraception (e.g., barrier containing additional spermicide foam or jelly, the intrauterine device, hormonal contraception). 绝经后女性必须已经绝经多1年并且具有升高的血清FSH。 Postmenopausal women with postmenopausal must have been more than a year and have elevated serum FSH.

[0318] -在研宄期间愿意食用提供的食物。 [0318] - willing to eat the food supplied during the study based on.

[0319] -在整个研宄期间避免剧烈运动。 [0319] - Avoid strenuous exercise during the entire study based on. 对象将不开始新的运动计划或参与任何非常剧烈的强体力活动。 Object will not begin a new exercise program or participate in any very strenuous physical exertion.

[0320] 排除标准 [0320] Exclusion Criteria

[0321] 下述标准将可能的对象排除在本研宄之外。 [0321] The following criteria excluded potential objects of the present study based.

[0322] -处于妊娠期(β人绒毛膜促性腺激素测试为阳性)或哺乳期的女性。 [0322] - or women in pregnancy (β human chorionic gonadotropin test positive) breast-feeding.

[0323] -当前或最近(5年内)药物或酒精滥用史。 [0323] - current or recent (within 5 years) history of drug or alcohol abuse.

[0324] -可能干扰药物吸收、分布、代谢或排泄的病史或任何当前病症。 [0324] - might interfere with drug absorption, distribution, metabolism or excretion history or any current condition.

[0325] -在本研宄初始给药之前30天内使用含有阿片样物质的药物。 [0325] - 30 days of use containing an opioid drugs prior to the present study based on the initial dose.

[0326] -已知对氢可酮、纳曲酮或相关化合物的过敏史。 [0326] - Known hydrocodone, naltrexone, or allergies related compounds.

[0327] -无论何种病因的任何频发恶心或呕吐的病史。 [0327] - whether any of frequent nausea or vomiting history of what the cause is.

[0328] -伴有后遗症的任何癫痫或头部外伤病史。 [0328] - Any history of seizures or head trauma with sequelae.

[0329] -在本研宄开始给药之前30天内参加了临床药物研宄。 [0329] - Before the start of this study based on the administration 30 days to participate in a clinical drug study based on.

[0330] -在本研宄开始给药之前30天内的任何重大疾病。 [0330] - any major illness before the start of this study based on administration within 30 days.

[0331] -在开始给药之前7天内使用任何药物,包括甲状腺激素治疗(激素避孕是允许的)、维生素、草药和/或矿物质补充剂。 [0331] - in 7 days before the start of administration of any medication including thyroid hormone therapy (hormonal contraception is allowed), vitamins, herbal, and / or mineral supplements.

[0332] -包括任何以下状况的异常心脏病症 [0332] - include any of the following conditions of abnormal cardiac disorders

[0333] •在筛查时QTc间期^ 450毫秒(使用Fridericia校正计算)。 [0333] • ^ 450 ms (using Fridericia correction calculation) at screening QTc interval.

[0334] •在治疗期间QTc间期彡480毫秒(使用Fridericia校正计算)。 [0334] • QTc interval of 480 ms during treatment San (using Fridericia correction calculation).

[0335] -在施用所研宄药物之前10小时和之后4小时拒绝解除食物以及在每个限制期内拒绝完全解除含有咖啡因或黄嘌呤的饮料。 [0335] - 4 hours and 10 hours after the refusal before the administration of the drug release study based foods and reject completely released caffeinated beverages or xanthine restriction in each period.

[0336] -在开始施用所研宄药物(第1天)之前48小时或在研宄期间的任何时间拒绝解除消费酒精饮料。 [0336] - At the beginning of the study based on the drug administration (Day 1) 48 hours prior to release or reject the consumption of alcoholic beverages at any time during the study based.

[0337] -吸烟史或在施用所研宄药物45天内使用烟碱产品或尿可替宁测试为阳性。 [0337] - a history of smoking or administration of the drug within 45 days of the study based on the use of nicotine products or urine cotinine test positive.

[0338] -在施用所研宄药物之前60天内或本研宄期间的任何时间以及完成本研宄之后30天捐献血液或血液制品,本方案所需的除外。 [0338] - 60 days, or at any time during and after completion of this study based on the present study based on 30 days of donated blood or blood products prior to administration of the study based drugs required by this protocol excluded.

[0339] -施用所研宄药物之前14天内或本研宄期间的任何时间捐献血浆,本方案所需的除外。 [0339] - 14 days of administration or at any time during the present study based plasma donations earlier study based drugs, except for the program desired.

[0340] -尿药物筛查或酒精筛查为阳性结果。 [0340] - urine drug or alcohol screen positive screening results.

[0341] -HBsAg、抗HCV为阳性结果。 [0341] -HBsAg, anti-HCV positive results.

[0342] -纳洛酮HCl激发测试为阳性。 [0342] - Naloxone HCl challenge test was positive.

[0343] -存在吉尔伯综合征(Gilbert' s Syndrome)或任何已知的肝胆异常。 [0343] - presence of Gilbert syndrome (Gilbert 's Syndrome) or any known hepatobiliary abnormalities.

[0344] -仅对于本研宄的任选毛发采样部分,头发(scalp hair)量不足以提供足够的样本。 [0344] - optionally only for part of the study based on the hair samples, the hair (scalp hair) an amount insufficient to provide an adequate sample.

[0345] -研宄人员认为对象由于本排除标准中未具体指出的一种或更多种原因而不适合。 [0345] - a Subsidiary believe objects for one or more reasons not specifically pointed out that the standard of this exclusion is not suitable.

[0346] 将符合所有纳入标准并且无任何排除标准的对象随机化进入到本研宄中。 [0346] meeting all the inclusion criteria and no exclusion criteria were randomized into objects present in a Subsidiary.

[0347] 在筛查时为各对象分配独特的对象号码。 [0347] assigned a unique number for the target objects at screening. 对象号码的分配为升序并且没有号码遗漏。 Assignment numbers in ascending order and no missing numbers. 将对象号码用于所有研宄文件。 The target number for all study based on documents.

[0348] 检入流程 [0348] check-in process

[0349] 仅在阶段1的第-1天,接纳对象到研宄单位(study unit)并接受纳洛酮HCl激发测试。 [0349] in the first stage only 1 day -1, the study based on the object receiving unit (study unit) and receiving Naloxone HCl challenge test. 对于在本研宄中继续的对象而言,测试的结果必须为阴性。 For continue in this study based on the object, the result of the test must be negative. 在接受纳洛酮HCl之前和之后测量生命体征和SPO2。 Before accepting Naloxone HCl and after measurement of vital signs and SPO2.

[0350] 在每个阶段检入时还对所有对象进行以下流程: [0350] The following process for all objects at each stage checked Shihai:

[0351] -核实纳入/排除标准,包括核实遵从咖啡因和黄嘌呤限制标准的意愿。 [0351] - Verification of inclusion / exclusion criteria, including verification of compliance with caffeine and xanthine restriction criteria will.

[0352] -生命体征(坐下约5分钟之后)和SpO2。 [0352] - Vital signs (after being seated for approximately 5 minutes) and SpO2.

[0353] -HDYF(你感觉如何(How do you feel))?在测量生命体征的同时进行询问。 [0353] -HDYF (How do you feel (How do you feel))? Interrogated in the measurement of vital signs at the same time.

[0354] -在测量生命体征和SpO2之后收集临床实验室评价(仅阶段1的第-1天),包括生物化学(禁食至少4小时)、血液学和尿分析。 [0354] - Clinical laboratory evaluations collected (only stage 1, day -1) and after Sp02 measuring vital signs, including biochemistry (fasted at least 4 hours), hematology, and urinalysis.

[0355] -酒精(通过尿或血液酒精或酒精检测仪检查)、可替宁和所选的滥用药物(通过尿检)筛查。 [0355] - alcohol (blood alcohol or urine or via breathalyzer test), cotinine, and selected drugs of abuse (by urine) screening.

[0356] -尿妊娠测试(对于所有女性对象)。 [0356] - urine pregnancy test (for all female subjects).

[0357] -伴随用药的监测和记录。 [0357] - monitoring and recording of concomitant medication.

[0358] -AE监测和记录。 [0358] -AE monitored and recorded.

[0359] 对于继续参加本研宄的对象而言,在给药之前,药物筛选(包括酒精和可替宁)的结果必须可得到并且是阴性的。 [0359] For the object to continue to participate in this study based on, prior to administration, drug screen (including alcohol and cotinine) results to be available and negative. 此外,在检入时和整个本研宄中对伴随用药和其他限制的持续顺从性进行核实并记录在适当的源文件(source documentation)中。 Further, on check and verify this study based on the whole sustained compliance concomitant medication and other restrictions and recorded in the appropriate source files (source documentation) in.

[0360] 治疗阶段流程 [0360] treatment stage of the process

[0361] 对于每个迭代预先确定待研宄的治疗。 [0361] Treatment of a Subsidiary to be determined in advance for each iteration. 在迭代内,随着数据变得可用,治疗从队列(cohort)中撤出。 In the iteration, as data becomes available, the queue is withdrawn from the treatment (cohort). 撤出的治疗被其余治疗的重复所替换。 Treatment of withdrawal is replaced by repeated treatment of the rest.

[0362] -在阶段1的首次给药之前,将对象随机化至治疗顺序。 [0362] - prior to the first dose of stage 1, the target randomized to a treatment sequence.

[0363] -在所研宄药物给药之前-12小时,对象用240mL水接受纳曲酮HCl片剂(50mg)。 [0363] - 12 hours, the subject received naltrexone HCl tablet (50mg) with 240mL water prior to the study based on drug administration.

[0364] -在所研宄药物施用之前(除了阶段1),对对象进行化学(禁食至少4小时)、血液学和尿分析测试。 [0364] - (except that in stage 1), chemically object (fasted at least 4 hours), hematology, and urinalysis test before the study based on drug administration.

[0365] -对象如下用240mL水施用所研宄药物: [0365] - an object with 240mL of water as the study based on the drug administration:

[0366] ·对于禁畲治疗: [0366] · For Ban She treatment:

[0367] 10小时过夜禁食之后,对象用240mL水施用所研宄药物。 [0367] 10 hours after an overnight fast, with the object of administration of the study based on water 240mL drugs. 接受禁食治疗的对象在给药后4小时继续禁食。 Fasting subject receiving fasted treatments continued 4 hours after dosing.

[0368] ·对于讲畲治疗: [0368] · She speaks for the treatment of:

[0369] 10小时过夜禁食之后,对象在用240mL水施用所研宄药物之前30分钟食用标准餐(FDA高脂肪早餐)。 [0369] 10 hours after an overnight fast, the study based on the object before the drug is administered 30 minutes with 240mL of water were fed a standard meal (FDA high-fat breakfast). 给药后至少4小时不允许进食。 Eating at least 4 hours after dosing allowed. 让对象很清楚,所有膳食都应在指定的时限内食用。 Let the object is very clear, all meals should be eaten within a specified time limit.

[0370] •对象在站立或处于垂直式坐姿时接受所研宄药物剂量。 [0370] • Subjects received while standing or in an upright sitting position of the study based on the dose.

[0371] •非给药研宄日不需要禁食。 [0371] • Non-dosing study based on daily fasting is not required.

[0372] -在相对于每种所研宄药物给药的第_12、0、12、24和36小时时,对象用240mL水接受纳曲酮HCl 50mg片剂。 [0372] - during the study based on each of _12,0,12,24 drug administration, and 36 hours relative to the subject received naltrexone HCl 50mg tablets with 240mL water.

[0373] -对于接受60mg或更多的氢可酮剂量的对象,在开始给药之前和给药后持续整个24小时内连续监测SpO2。 [0373] - for receiving 60mg or more hydrogen objects one dose, continuously monitored continuously throughout the 24 hours before the start of dosing and SpO2.

[0374] -对每个阶段而言,于给药前和给药后1、2、4、6、8、12、24、36、48和72小时获得生命体征(坐下约5分钟之后)和SpO2。 [0374] - for each phase, and prior to administration 1,2,4,6,8,12,24,36,48 and 72 hours post-dose vital signs is obtained (after about 5 minutes to sit down) and SpO2.

[0375] -HDYF(你感觉如何)? [0375] -HDYF (how you feel)? 在测量生命体征的同时进行询问。 For questioning in simultaneous measurement of vital signs.

[0376] -给药后24小时对对象进行生物化学(禁食至少4小时)、血液学和尿分析测试。 [0376] - 24 hours after administration to the object biochemical (fasting for at least 4 hours), hematology, and urinalysis test.

[0377] -另外,给药前和给药后约12、24和48小时对每位对象进行12导联ECG。 [0377] - In addition, about 12, 24 and 48 hours before and after administration of each object 12 lead ECG. 如果QTcF超过480毫秒,则该对象因不良事件的原因而终止。 If QTcF more than 480 milliseconds, the object for reasons of adverse events was terminated.

[0378] -对每个阶段而言,于给药前和给药后0. 5、1、1. 5、2、2. 5、3、3. 5、4、5、6、8、10、12、 14、18、24、36、48和72小时从每位对象获得用于测定氢可酮血浆浓度的血液样品。 [0378] -... For each phase, before and after administration of 0. 5,4,5,6,8,10 5,1,1 5,2,2 5,3,3 , 12, 14,18,24,36,48 and 72 hours obtained from each subject for determination of hydrogen concentration in a blood sample can be plasma ketone.

[0379] -在给药之前一天,对象被限定在单元(从检入到单元)直到其48小时流程完成的时间。 [0379] - one day, the object is defined in the completed unit (from the sample into the cell) flow time until 48 hours prior to administration. 对象返回到单元进行72小时流程。 Object is returned to the flow cell for 72 hours.

[0380] -在研宄期间,记录AE和伴随用药。 [0380] - during the study based on record AE and concomitant medication.

[0381] 另外,使对象知道,研宄工作人员立即记录任何/全部呕吐发作是非常重要的并且该信息对试验的适当进行和结果是至关重要的。 [0381] In addition, the object knows, a Subsidiary staff immediately record any / all of emetic episodes and this is very important information for the proper conduct and the results of tests is critical. 使对象知道,它们不会因报告呕吐的情况而以任何方式受处罚。 The target know that they will not report vomiting and punished in any way. 指示研宄工作人员仔细地记录任何/全部呕吐情况。 Indicating a Subsidiary staff carefully record any / all of the vomiting.

[0382] 研宄完成流程 [0382] study based on complete process

[0383] 在研宄结束(研宄完成)时、接受他们所研宄药物的最后剂量之后7至10天或在早期中止研宄时在研宄地点对所有对象均进行以下流程。 [0383] at the end of a Subsidiary (a Subsidiary completed), after receiving their last dose of study based on drug 7-10 days or on all the objects in the study based on the following process abort study based on location early.

[0384] -伴随用药评价。 [0384] - concomitant medication evaluation.

[0385] -生命体征(坐下约5分钟之后)和SpO2。 [0385] - Vital signs (after being seated for approximately 5 minutes) and SpO2.

[0386] -HDYF ?在测量生命体征的同时进行询问。 [0386] -HDYF? Interrogated in the measurement of vital signs at the same time.

[0387] -体检。 [0387] - a medical examination.

[0388] -12 导联ECG。 [0388] -12-lead ECG.

[0389] -临床实验室评价(包括生物化学[禁食至少4小时]、血液学和尿分析)。 [0389] - Clinical laboratory evaluations (including biochemistry [fasted at least 4 hours], hematology, and urinalysis).

[0390] -AE 评价。 [0390] -AE evaluation.

[0391] -血清妊娠测试(仅对于女性对象而言)。 [0391] - serum pregnancy test (for female subjects only).

[0392] 本研宄的初步结果(draft result)如图4~6和以下表13所示: [0392] Preliminary results of this study based on the (draft result) FIGS. 4 to 6 and shown in Table 13:

[0393] 表13初步血浆氢可酮药物代谢动力学参数的总结 [0393] Table 13 summarizes the initial plasma hydrocodone metabolite pharmacokinetic parameters

[0394] [0394]

Figure CN104856967AD00381

[0396] 实施例14~20 [0396] Examples 14 to 20

[0397] 根据以下表14 (片剂M、N、0、P)和表15 (片剂Q、R、S)分别制备了包含总计20、 30、40、60、80、100或12011^重酒石酸氢可酮的七种不同的压制包衣片剂(称为片剂1~5)。 [0397] According to Table 14 (Tablet M, N, 0, P) and Table 15 (Tablet Q, R, S) each comprising a total of 20, 30,40,60,80,100 or prepared ^ weight 12011 different pressing hydrocodone bitartrate seven-coated tablets (referred to as 1-5 tablets).

[0398] 表14 (片剂Μ、Ν、0、Ρ) [0398] Table 14 (tablet Μ, Ν, 0, Ρ)

[0399] [0399]

Figure CN104856967AD00391

[0400] 表15 (片剂Q、R、S) [0400] Table 15 (Tablet Q, R, S)

[0401] [0401]

Figure CN104856967AD00401

[0402] 将重酒石酸氢可酮、微晶纤维素和羟丙基纤维素装入高剪切混合器中。 [0402] The hydrocodone bitartrate, microcrystalline cellulose and hydroxypropyl cellulose was charged in a high shear mixer.

[0403] 以低速并关闭切碎器使干混混合物混合1分钟,之后以高速并打开切碎器下进行混合。 [0403] In a low speed and chopper off enables dry-blended mixture was mixed for 1 minute at high speed and the chopper open mixing. 将水添加至混合物中直到添加了期望量的水,从而产生湿颗粒。 Water was added to the mixture until the desired amount of water is added to produce wet granules.

[0404] 之后将湿颗粒通过筛选磨碎机以去结块,并转移至流化床干燥器用于干燥。 [0404] After the wet granules through a screening mill to remove lumps and transferred to a fluid bed dryer for drying.

[0405] 之后将干混合物通过细孔筛直到获得目标颗粒大小范围(< 1. 0% )。 After [0405] The dry mixture through a fine screen until the target particle size range (<1.0%).

[0406] 之后将干燥的经筛过的颗粒通过筛选磨碎机,将有效颗粒收集在不锈钢容器中。 After [0406] The dried granules was sieved through a screening mill, an effective particle collection in a stainless steel vessel. 使V形共混机填装约一半的聚环氧乙烷(P0LY0X WSR-205);适当量的有效颗粒(经调整用于测定);铝色淀;以及剩余的聚环氧乙烷(P0LY0X WSR-205),然后使混合物共混10分钟。 The V-shaped blender for about half filled polyethylene oxide (P0LY0X WSR-205); an effective amount of a suitable particle (adjusted for assay); aluminum lakes; and the remaining polyethylene oxide (P0LY0X WSR-205), and then the mixture was blended for 10 minutes.

[0407] 之后使V形共混机填装硬脂酸镁并使混合物共混2分钟,然后排放到不锈钢滚筒(drum)中。 After [0407] the V-shaped blender and magnesium stearate are blended filling mixture for 2 minutes, and then discharged into a stainless steel drum (Drum) In.

[0408] 使V形搅拌器填装约一半的聚环氧乙烷(P0LY0X WSR-303);适当量的有效颗粒(经调整用于测定);以及剩余的聚环氧乙烷(P0LY0X WSR-303),然后使混合物共混10分钟。 [0408] the V-shaped blender for about half filled polyethylene oxide (P0LY0X WSR-303); an effective amount of a suitable particle (adjusted for assay); and the remaining polyethylene oxide (P0LY0X WSR- 303), and then the mixture was blended for 10 minutes.

[0409] 之后使V形共混机填装硬脂酸镁;共混2分钟,然后排放到不锈钢滚筒中。 After [0409] the V-shaped blender filled magnesium stearate; blended for 2 minutes and then discharged into a stainless steel drum.

[0410] 用8. 75mm圆形浅凹工具(shallow concave tooling)设置压机的左侧,用12mm 圆形浅凹倒角边工具(shallow concave bevel edge tooling)设置压机的右侧。 [0410] disposed on the left side with the press tool 8. 75mm circular dimples (shallow concave tooling), disposed on the right side of the press with bevelled edges 12mm circular dimples tool (shallow concave bevel edge tooling).

[0411] 之后,将核心共混物(经着色)填装至左侧料斗(重力进料系统)中以开始核心压制。 After [0411] the core blend (pigmented) left filled to a hopper (gravity feed system) to initiate pressing the core.

[0412] 将核心重量调节至目标重量(300mg,+/-5% )。 [0412] The core weight was adjusted to target weight (300mg, + / - 5%).

[0413] 之后,将干包衣共混物(白色至灰白色)填装至右侧料斗(重力进料系统)中以开始片剂压制。 After [0413] the dry coating blend (gray to white) to the right filling hopper (gravity feed system) to start tablet compression.

[0414] 在核心布置之后,将初始干包衣填料和随后的干包衣填料调节至700mg的目标总片剂重量(300mg核心+400mg干包衣)。 [0414] After the core arrangement, the initial and subsequent dry coated filler dry coated filler was adjusted to the target total tablet weight of 700mg (300mg + 400mg dry coated core).

[0415] 对于欧巴代颜色分散体(目标20%固体),使混合器皿填装适当量的纯化水,调节混合器速度以形成涡流。 [0415] For the Color Opadry dispersion (20% solids target), mixing the appropriate amount of filling containers of purified water, adjusting the mixer speed to form a vortex. 经2~5分钟将欧巴代颜色粉末添加至器皿中,并混合直到产生均匀的分散体(最少1小时)。 2 to 5 minutes after adding Opadry color powder to the vessel and mixed until a homogenous dispersion (less than 1 hour).

[0416] 对于欧巴代透明分散体(目标7.5%固体),使分开的混合器皿填装适当量的纯化水,并调节混合器速度以形成涡流。 [0416] For the Opadry clear dispersion (solids 7.5% certain), separate mixing vessel filling an appropriate amount of purified water, and adjusting the mixer speed to form a vortex. 经2~5分钟(目标3分钟)将欧巴代透明粉末添加至器皿中,并混合直到产生均匀的分散体(最少1小时)。 (Goal 3 minutes) was added over 2 to 5 minutes Opadry clear powder to the vessel and mixed until a homogenous dispersion (less than 1 hour).

[0417] 之后,将压制包衣片剂转移至多孔的包衣锅并用欧巴代颜色分散体进行薄膜包衣,直到目标重量增长0. 7%~1. 5%。 After [0417] the press-coated tablets were transferred to perforated coating pan and film coated with Opadry color dispersion, until the target weight gain of 0.7% to 1.5%.

[0418] 将加热温度提高,然后对于72°C的目标排气口温度,将片剂熟化约30分钟,之后冷却。 [0418] The heating temperature is increased, then the target exhaust temperature of 72 ° C, the tablets were cured for about 30 minutes, then cooled.

[0419] 用欧巴代颜色分散体继续进行片剂包衣,直到目标重量增长为3 % (包括来自之前包衣的重量增长)。 [0419] to proceed with tablet coating Opadry color dispersion, until the target weight gain of 3% (including the weight of the coating from the previous growth).

[0420] 之后,用欧巴代透明分散体对片剂进行膜包衣,直到最终目标重量增长为5%。 After [0420], tablets were film coated with Opadry clear dispersion, until the final target weight gain of 5%.

[0421] 对于这些压制包衣的20mg、30mg、40mg、60mg、80mg、IOOmg和120mg片剂,溶出结果(经时间释放的活性物% )示于以下表16中。 [0421] For the press-coated 20mg, 30mg, 40mg, 60mg, 80mg, IOOmg and 120mg tablets, the dissolution results (time-release of the active substance%) shown in Table 16 below.

[0422] 表16 [0422] Table 16

[0423] 压制包衣的20、40、60、80、120mg片剂的溶出结果(SGF,η = 12) [0423] Dissolution results 20,40,60,80,120mg press-coated tablets (SGF, η = 12)

[0424] [0424]

Figure CN104856967AD00421

[0425] 实施例21 [0425] Example 21

[0426] 用实施例14~20的氢可酮制剂(HYD)进行健康成年男性和女性对象中的随机、 开放标签、单剂量、5种治疗、4阶段交叉的不完全模块研宄(incomplete block study)。 [0426] with hydrogen in Examples 14 to 20 may be one formulation (HYD) for healthy adult male and female subjects in a randomized, open-label, single-dose, 5-treatment, 4-period crossover incomplete block study based on (incomplete block study). 本研宄由最多5种治疗、交叉4阶段构成。 This study based on the treatment of a maximum of 5, 4 stage cross configuration.

[0427] 研宄的HYD片剂强度或剂量为: [0427] HYD study based on the dose or tablet strength:

[0428] .IX2Omg HYD 片剂 [0428] .IX2Omg HYD tablet

[0429] .lX40mgHYD 片剂 [0429] .lX40mgHYD tablets

[0430] .lX60mgHYD 片剂 [0430] .lX60mgHYD tablets

[0431] .IXSOmg HYD 片剂 [0431] .IXSOmg HYD tablet

[0432] · lX120mg HYD 片剂 [0432] · lX120mg HYD tablet

[0433] 在禁食状态下用8盎斯(240mL)水分别作为单次剂量经口施用治疗。 [0433] with 8 oz. (240 mL) water as a single dose were administered orally in the fasted state treatment.

[0434] 因为该研宄是在健康人对象中进行的,所以施用阿片样拮抗剂纳曲酮盐酸盐以将与阿片样物质相关的不良事件降至最低。 [0434] Since this study based was conducted in healthy human subjects, the administration of the opioid antagonist naltrexone hydrochloride adverse events associated with the opioid to a minimum.

[0435] 对象选择 [0435] Object Selection

[0436] 筛选流程 [0436] screening process

[0437] 在施用首次剂量之前28天内进行的筛选访视时对所有可能的对象进行下述筛选流程: [0437] The following screening process carried out on all possible objects prior to administration of the first dose when the screening visit conducted within 28 days:

[0438] -知情同意。 [0438] - informed consent.

[0439] -任选药物基因组采样的知情同意。 [0439] - optionally pharmacogenomic samples informed consent.

[0440] -任选毛发采样的知情同意。 [0440] - optionally a hair sample informed consent.

[0441] -体重、身高、身体质量指数(BMI)和人口统计学数据。 [0441] - weight, height, body mass index (BMI), and demographic data.

[0442] -纳入/排除标准的评价。 [0442] - inclusion / exclusion criteria evaluation.

[0443] -病史和用药史,包括伴随用药。 [0443] - medical and medication history, including concomitant medication.

[0444] -坐下约5分钟之后的生命体征(收缩/舒张血压、脉搏率、呼吸速率、口腔温度) 和SpO2。 [0444] - after vital signs sit for about 5 minutes (systolic / diastolic blood pressure, pulse rate, respiratory rate, oral temperature) and SpO2.

[0445] -站立约2分钟之后的另一些生命体征(收缩/舒张血压和脉搏率)。 [0445] - stand other vital signs (systolic / diastolic blood pressure and pulse rate) after about 2 minutes.

[0446] -HDYF ?在测量生命体征的同时进行询问。 [0446] -HDYF? Interrogated in the measurement of vital signs at the same time.

[0447] -常规体检。 [0447] - routine physical examination.

[0448] -至少4小时禁食后的临床实验室评价(包括生物化学、血液学和尿分析)。 [0448] - Clinical laboratory evaluations at least 4 hours after fasting (including biochemistry, hematology, and urinalysis).

[0449] -12导联ECG。 [0449] -12-lead ECG. QTcF不超过450毫秒。 QTcF does not exceed 450 milliseconds.

[0450] -肝炎筛查(包括乙型肝炎表面抗原[HBsAg]、丙型肝炎抗体[抗HCV])。 [0450] - Screening hepatitis (including hepatitis B surface antigen [HBsAg], hepatitis C antibody [anti-HCV]).

[0451] -酒精、可替宁和所选滥用药物的筛查。 [0451] - alcohol, abusable drug cotinine screening and selection.

[0452] -血清妊娠测试,仅女性对象;血清促卵泡刺激激素(FSH),仅绝经后女性。 [0452] - serum pregnancy test, females only objects; serum follicle stimulating hormone (FSH), postmenopausal females only.

[0453] -血清妊娠测试(仅女性对象)。 [0453] - serum pregnancy test (female subjects only).

[0454] -血清卵泡刺激素(FSH)测试(仅绝经后女性) [0454] - serum follicle stimulating hormone (FSH) test (postmenopausal females only)

[0455] 纳入标准 [0455] inclusion criteria

[0456] 符合下述标准的对象被纳入到本研宄中。 [0456] subject met the following criteria were included in the study based on this.

[0457] -提供书面知情同意。 [0457] - providing written informed consent.

[0458] -年龄在18至50岁(包括端值)的男性和女性。 [0458] - men and women aged 18-50 years of age (inclusive) of.

[0459] -在研宄期间愿意食用提供的食物。 [0459] - willing to eat the food supplied during the study based on.

[0460] -体重在50至IOOkg(IK)至220镑)和BMI在18至30 (kg/m2)(包括端值)。 [0460] - weighing 50 to IOOkg (IK) to 220 pounds) and a BMI of 18 to 30 (kg / m2) (inclusive).

[0461] -直到研宄访问结束愿意避免剧烈运动。 [0461] - until the end of the study based on access are willing to avoid strenuous exercise. 对象将不开始新的运动计划或参与任何非常剧烈的强体力活动。 Object will not begin a new exercise program or participate in any very strenuous physical exertion.

[0462] -通过病史、体检、临床实验室值、生命体征和ECG确认为健康并且无显著异常发现。 [0462] - by history, physical examination, clinical laboratory values, vital signs and ECG recognized as healthy and free of significant abnormal findings.

[0463] -育龄女性必须使用充分且可靠的避孕法(例如含有另外的杀精子剂泡沫剂或胶冻剂的屏障、宫内避孕器、激素避孕)。 [0463] - Women of childbearing age must be adequate and reliable method of contraception (e.g., barrier containing additional spermicide foam or jelly, the intrauterine device, hormonal contraception). 绝经后女性必须已经绝经多1年并且具有升高的血清FSH。 Postmenopausal women with postmenopausal must have been more than a year and have elevated serum FSH.

[0464] 排除标准 [0464] Exclusion Criteria

[0465] 下述标准将可能的对象排除在本研宄之外。 [0465] The following criteria excluded potential objects of the present study based.

[0466] -处于妊娠期(β人绒毛膜促性腺激素测试为阳性)或哺乳期的女性。 [0466] - or women in pregnancy (β human chorionic gonadotropin test positive) breast-feeding.

[0467] -当前或最近(5年内)药物或酒精滥用史。 [0467] - current or recent (within 5 years) history of drug or alcohol abuse.

[0468] -可能干扰药物吸收、分布、代谢或排泄的病史或任何当前病症。 [0468] - might interfere with drug absorption, distribution, metabolism or excretion history or any current condition.

[0469] -在本研宄中所研宄药物的开始给药之前的过去30天内使用含有阿片样物质的药物。 [0469] - the use of drugs containing the last 30 days prior to opioid administration of drug began the study based on the present study based.

[0470] -已知对氢可酮、纳曲酮或相关化合物的过敏史。 [0470] - Known hydrocodone, naltrexone, or allergies related compounds.

[0471] -无论何种病因的任何频发恶心或呕吐的病史。 [0471] - whether any of frequent nausea or vomiting history of what the cause is.

[0472] -伴有后遗症的任何癫痫或头部外伤病史。 [0472] - Any history of seizures or head trauma with sequelae.

[0473] -在本研宄中所研宄药物的开始给药之前30天内参加了临床药物研宄。 [0473] - In this study based on the administration before the start of the study based on drug within 30 days to participate in a clinical drug study based on.

[0474] -在本研宄中所研宄药物的开始给药之前30天内的任何重大疾病。 [0474] - any major disease 30 days before the start of administration of the drug in this study based on research in the traitor.

[0475] -在所研宄药物的开始给药之前7天内使用任何药物,包括甲状腺激素治疗(激素避孕和在具有或没有孕激素下以雌激素形式的激素替代治疗是允许的)、维生素、草药和/ 或矿物质补充剂。 [0475] - 7 days before the start of use of any drug in the study based on the administration of drugs comprising thyroid hormone therapy (hormonal contraception and with or without the estrogen-progestin hormone replacement therapy form is allowed), vitamins, herbs and / or mineral supplements.

[0476] -任何延长的QT间期或心律疾病的个人或家族病史 [0476] - between any prolonged QT personal or family history of the disease or heart rhythm

[0477] -包括任何以下状况的异常心脏病症 [0477] - include any of the following conditions of abnormal cardiac disorders

[0478] •在筛查时QTc间期^ 450毫秒(使用Fridericia校正计算)。 [0478] • ^ 450 ms (using Fridericia correction calculation) at screening QTc interval.

[0479] •在治疗期间QTc间期彡480毫秒(使用Fridericia校正计算)。 [0479] • QTc interval of 480 ms during treatment San (using Fridericia correction calculation).

[0480] -在施用所研宄药物之前10小时和之后4小时拒绝解除食物以及在每个限制期内拒绝完全解除含有咖啡因或黄嘌呤的饮料。 [0480] - 4 hours and 10 hours after the refusal before the administration of the drug release study based foods and reject completely released caffeinated beverages or xanthine restriction in each period.

[0481] -在开始施用所研宄药物(第1天)之前48小时和直到研宄访视结束的任何时间拒绝解除消费酒精饮料。 [0481] - At the beginning of the study based on administration of the drug (Day 1) and at any time prior to 48 hours until the end of the study based on visits refusal to lift consumption of alcoholic beverages.

[0482] -在开始施用所研宄药物之前30天内或直到研宄询问结束的任何时间捐献血液或血液产品,本方案所需的除外。 [0482] - or until the end of the study based on the inquiry at any time of donated blood or blood products, with the exception of the program required before the start of the study based on administration of the drug within 30 days.

[0483] -吸烟史或在开始施用所研宄药物45天内使用烟碱产品或尿可替宁测试为阳性。 [0483] - a history of smoking or at the onset of administration of the drug within 45 days of the study based on the use of nicotine products or urine cotinine test positive.

[0484] -尿药物筛查或酒精筛查为阳性结果。 [0484] - urine drug or alcohol screen positive screening results.

[0485] -HBsAg、抗HCV为阳性结果。 [0485] -HBsAg, anti-HCV positive results.

[0486] -纳洛酮HCl激发测试为阳性。 [0486] - Naloxone HCl challenge test was positive.

[0487] -存在吉尔伯综合征或任何已知的肝胆异常。 [0487] - presence of Gilbert's Syndrome or any known hepatobiliary abnormalities.

[0488] -研宄人员认为对象由于本排除标准中未具体指出的一种或更多种原因而不适合。 [0488] - a Subsidiary believe objects for one or more reasons not specifically pointed out that the standard of this exclusion is not suitable.

[0489] 将符合所有纳入标准并且无任何排除标准的对象随机化进入到本研宄中。 [0489] meeting all the inclusion criteria and no exclusion criteria were randomized into objects present in a Subsidiary.

[0490] 在筛查时将为对象分配独特的对象号码。 [0490] will be assigned a unique number in the subject screening object. 对象号码的分配为升序并且没有号码遗漏。 Assignment numbers in ascending order and no missing numbers. 将对象号码用于所有研宄文件。 The target number for all study based on documents.

[0491] 检入流程 [0491] check-in process

[0492] 仅在阶段1的第-1天,接纳对象到研宄单元并接受纳洛酮HCl激发测试。 [0492] in the first stage only 1 day -1, admission to the study based on the object and receiving unit Naloxone HCl challenge test. 对于继续本研宄的对象而言,测试的结果必须为阴性。 For continue this study based on the object, the result of the test must be negative. 在接受纳洛酮HCl之前和之后测量生命体征和SPO2。 Before accepting Naloxone HCl and after measurement of vital signs and SPO2.

[0493] 在每个阶段检入时还对所有对象进行以下流程: [0493] The following process for all objects at each stage checked Shihai:

[0494] -核实纳入/排除标准,包括核实遵从咖啡因和黄嘌呤限制标准的意愿。 [0494] - Verification of inclusion / exclusion criteria, including verification of compliance with caffeine and xanthine restriction criteria will.

[0495] -生命体征(坐下约5分钟之后)和SpO2。 [0495] - Vital signs (after being seated for approximately 5 minutes) and SpO2.

[0496] -HDYF(你感觉如何)? [0496] -HDYF (how you feel)? 在测量生命体征的同时进行询问。 For questioning in simultaneous measurement of vital signs.

[0497] -在测量生命体征和SpO2之后收集临床实验室评价(仅阶段1的第-1天),包括生物化学(禁食至少4小时)、血液学和尿分析。 [0497] - Clinical laboratory evaluations collected (only stage 1, day -1) and after Sp02 measuring vital signs, including biochemistry (fasted at least 4 hours), hematology, and urinalysis.

[0498] -酒精(通过尿或血液酒精或酒精检测仪检查)、可替宁和所选的滥用药物(通过尿检)筛查。 [0498] - alcohol (blood alcohol or urine or via breathalyzer test), cotinine, and selected drugs of abuse (by urine) screening.

[0499] -尿妊娠测试(对于所有女性对象)。 [0499] - urine pregnancy test (for all female subjects).

[0500] -伴随用药的监测和记录。 [0500] - monitoring and recording of concomitant medication.

[0501] -AE监测和记录。 [0501] -AE monitored and recorded.

[0502] 对于继续参加本研宄的对象而言,在给药之前,药物筛选(包括酒精和可替宁)的结果必须可得到并且是阴性的。 [0502] For the object to continue to participate in this study based on, prior to administration, drug screen (including alcohol and cotinine) results to be available and negative. 此外,在检入时和整个本研宄中对伴随用药和其他限制的持续顺从性进行核实并记录在适当的源文件中。 In addition, verification on check-in and throughout this study based on the continued compliance concomitant medication and other restrictions and recorded in the appropriate source file.

[0503] 治疗阶段流程 [0503] treatment stage of the process

[0504] 对于每个迭代预先确定待研宄的治疗。 [0504] Treatment of a Subsidiary to be determined in advance for each iteration. 在迭代内,随着数据变得可用,治疗从队列中撤出。 In the iteration, as data becomes available, the treatment of withdrawal from the queue. 撤出的治疗被其余治疗的重复所替换。 Treatment of withdrawal is replaced by repeated treatment of the rest.

[0505] -在阶段1的首次给药之前,将对象随机化至治疗顺序。 [0505] - prior to the first dose of stage 1, the target randomized to a treatment sequence.

[0506] -在所研宄药物给药之前-12小时,对象用240mL水接受纳曲酮HCl片剂(50mg)。 [0506] - 12 hours, the subject received naltrexone HCl tablet (50mg) with 240mL water prior to the study based on drug administration.

[0507] -10小时过夜禁食之后,对象用240mL水施用所研宄药物。 [0507] 10 hours after an overnight fast, with the object of administration of the study based on water 240mL drugs. 对象在给药后4小时继续禁食。 Object continued fasting from food 4 hours after dosing.

[0508] •对象在站立或处于垂直式坐姿时接受所研宄药物给药。 [0508] • subject receives drug administration in the study based on standing or in an upright sitting position.

[0509] •非给药研宄日不需要禁食。 [0509] • Non-dosing study based on daily fasting is not required.

[0510] -在相对于每种所研宄药物给药的第_12、0、12、24和36小时时,对象用240mL水接受纳曲酮HCl 50mg片剂。 [0510] - during the study based on each of _12,0,12,24 drug administration, and 36 hours relative to the subject received naltrexone HCl 50mg tablets with 240mL water.

[0511] -对于接受60mg或更多的氢可酮剂量的对象,在开始给药之前和给药后持续整个24小时内连续监测SpO2。 [0511] - for receiving 60mg or more hydrogen objects one dose, continuously monitored continuously throughout the 24 hours before the start of dosing and SpO2.

[0512] -对每个阶段而言,于给药前和给药后1、2. 5、4、6、8、12、24、36、48和72小时获得生命体征(坐下约5分钟之后)和SpO2。 [0512] - For each subject at predose and 1, 2, and 72 hours after dosing 5,4,6,8,12,24,36,48 obtained vital signs (sit for about 5 minutes after) and SpO2.

[0513] -HDYF(你感觉如何)? [0513] -HDYF (how you feel)? 在测量生命体征的同时进行询问。 For questioning in simultaneous measurement of vital signs.

[0514] -给药前和给药后约12、24和48小时对每位对象进行12导联ECG。 [0514] - about 12, 24 and 48 hours after dosing and for 12-lead ECG for every subject prior to administration.

[0515] -对每个阶段而言,于给药前和给药后0. 5、1、2. 5、4、6、8、10、12、14、16、18、24、 36、48和72小时从每位对象获得用于测定氢可酮血浆浓度的血液样品。 [0515] - For each phase, before and after administration 0. 5,1,2 5,4,6,8,10,12,14,16,18,24, 36,48 and 72 hours obtained from each subject for determination of hydrogen concentration in a blood sample can be plasma ketone.

[0516] -在给药之前一天,对象被限定在单元(从检入到单元)直到其72小时流程完成的时间。 [0516] - one day, the object is defined in the completed unit (from the sample into the cell) flow time until 72 hours prior to administration.

[0517] -在研宄期间,记录AE和伴随药物。 [0517] - during the study based on record AE and concomitant medications.

[0518] 另外,使对象知道,研宄工作人员立即记录任何/全部呕吐发作是非常重要的并且该信息对试验的适当进行和结果是至关重要的。 [0518] In addition, the object knows, a Subsidiary staff immediately record any / all of emetic episodes and this is very important information for the proper conduct and the results of tests is critical. 使对象知道,它们不会因报告呕吐的情况而以任何方式受处罚。 The target know that they will not report vomiting and punished in any way. 指示研宄工作人员仔细地记录任何/全部呕吐情况。 Indicating a Subsidiary staff carefully record any / all of the vomiting.

[0519] 研宄完成流程 [0519] study based on complete process

[0520] 在研宄结束(研宄完成)时、接受他们所研宄药物的最后剂量之后7至10天或在早期中止研宄时在研宄地点对所有对象均进行以下流程。 [0520] at the end of a Subsidiary (a Subsidiary completed), after receiving their last dose of study based on drug 7-10 days or on all the objects in the study based on the following process abort study based on location early.

[0521] -伴随用药评价。 [0521] - concomitant medication evaluation.

[0522] -生命体征(坐下约5分钟之后)和SpO2。 [0522] - Vital signs (after being seated for approximately 5 minutes) and SpO2.

[0523] -HDYF ?在测量生命体征的同时进行询问。 [0523] -HDYF? Interrogated in the measurement of vital signs at the same time.

[0524] -体检。 [0524] - a medical examination.

[0525] -12 导联ECG。 [0525] -12-lead ECG.

[0526] -临床实验室评价(包括生物化学[禁食至少4小时]、血液学和尿分析)。 [0526] - Clinical laboratory evaluations (including biochemistry [fasted at least 4 hours], hematology, and urinalysis).

[0527] -AE 评价。 [0527] -AE evaluation.

[0528] -血清妊娠测试(仅对于女性对象而言)。 [0528] - serum pregnancy test (for female subjects only).

[0529] 初步结果如图7和以下表17所示: [0529] Preliminary results are shown in Table 7 and 17:

[0530] 表17初步血浆氢可酮药物代谢动力学参数的总结 [0530] Table 17 summarizes the initial plasma hydrocodone metabolite pharmacokinetic parameters

[0531] [0531]

Figure CN104856967AD00461

[0532] 本实施例中公开的具体实施方案并不是限制本发明的范围,所述实施例旨在举例说明本发明的一些方面,功能上等价的任何实施方案均落在本发明的范围内。 [0532] Specific embodiments of the present embodiment disclosed in the examples are not limiting the scope of the present invention, the described embodiments are intended to illustrate the scope of some aspects of the invention, any functionally equivalent embodiments of the present invention all fall . 实际上,除了本文中所示和所述的以外,对本发明的多种改动对于本领域技术人员而言是显而易见,并且旨在落在所附权利要求的范围内。 In fact, in addition to the illustrated and described herein, various modifications of the invention to those skilled in the art it will be apparent, and are intended to fall within the scope of the appended claims.

[0533] 本申请要求2010年12月22日提交的美国临时申请序列号61/426, 306的优先权, 其公开内容通过引用并入本文。 [0533] This application claims the United States December 22, 2010 Provisional Application Serial Number Priority 61/426, 306, the disclosure of which is incorporated herein by reference.

[0534] 本发明的另一些实施方案涉及: [0534] Other embodiments of the present invention relates to:

[0535] 1. -种固体控制释放剂型,其包含: [0535] 1 - one solid controlled release dosage form, comprising:

[0536] 核心,其包含分散在第一基质材料中的第一部分阿片样镇痛剂;和 [0536] core, the first portion comprising an opioid analgesic dispersed in a first matrix material; and

[0537] 壳,其包覆所述核心并且包含分散在第二基质材料中的第二部分所述阿片样镇痛剂; [0537] shell, which covers the core and comprising a second portion of the opioid analgesic dispersed in a second matrix material;

[0538] 其中,如通过在USP装置1(篮)中以IOOrpm在37°C下于900ml不含酶的模拟胃液(SGF)中体外溶出所测量的,从所述剂型释放的阿片样镇痛剂的量在8至24小时与经过时间在20%内成比例。 [0538] wherein, as measured by the USP Apparatus 1 (basket) at IOOrpm at 37 ° C for 900ml simulated gastric fluid without enzymes (SGF) as measured in vitro dissolution, releases the opioid analgesic from the dosage form agent in an amount of from 8 to 24 hours elapsed time and to be in a proportion of 20%.

[0539] 2.实施方案1的固体控制释放剂型,其中所述核心是压制片剂。 [0539] 2. The embodiment 1 of the solid controlled release dosage form, wherein the core is a compressed tablet.

[0540] 3.实施方案1或2的固体控制释放剂型,其中所述壳是压制包衣。 [0540] 3. The embodiment 1 or 2 of a solid controlled release dosage form, wherein the housing is a compression coating.

[0541] 4.实施方案1至3中任一项的固体控制释放剂型,其中所述第一基质材料包含聚环氧乙烷。 [0541] 4. The embodiments 1 to 3 of any one of the solid controlled release dosage form, wherein the first matrix material comprises polyethylene oxide.

[0542] 5.实施方案1至4中任一项的固体控制释放剂型,其中所述第二基质材料包含聚环氧乙烷。 [0542] The embodiments 1 to 4 of any one of a solid controlled release dosage form, wherein the second matrix material comprises polyethylene oxide.

[0543] 6.实施方案1至3中任一项的固体控制释放剂型,其中所述第一基质材料和所述第二基质材料均包含聚环氧乙烷。 [0543] 6. The embodiments 1 to 3 of any one of a solid controlled release dosage form, wherein the first matrix material and the second matrix material contains polyethylene oxide.

[0544] 7.实施方案6的固体控制释放剂型,其中所述第二基质材料中的所述聚环氧乙烷具有比所述第一基质材料中的所述聚环氧乙烷更高的黏度。 [0544] 7. The embodiment 6 of the solid controlled release dosage form, wherein the said second matrix material having polyethylene oxide is higher than the first matrix material is polyethylene oxide viscosity.

[0545] 8.实施方案4的固体控制释放剂型,其中所述第一基质材料包含平均分子量为约300, 000至约10, 000, 000的聚环氧乙烷。 [0545] 8. The embodiment 4 of the solid controlled release dosage form, wherein the first matrix material comprising an average molecular weight of about 300, about 000 to 10, 000, 000 polyethylene oxide.

[0546] 9.实施方案8的固体控制释放剂型,其中所述第一基质材料包含平均分子量为约500, 000至约1,000, 000的聚环氧乙烷。 [0546] 9. The embodiment 8 of a solid controlled release dosage form, wherein the first matrix material comprising an average molecular weight of about 500, 000 to about 1,000, 000 polyethylene oxide.

[0547] 10.实施方案5的固体控制释放剂型,其中所述第二基质材料包含平均分子量为约1,000, 000至约10, 000, 000的聚环氧乙烷。 [0547] 10. The embodiment 5 of the solid controlled release dosage form, wherein the second matrix material comprises an average molecular weight of about 000, about 000 to 10, 000, 000 polyethylene oxide.

[0548] 11.实施方案10的固体控制释放剂型,其中所述第二基质材料包含平均分子量为约6, 000, 000至约8, 000, 000的聚环氧乙烷。 [0548] Embodiment 11. The solid controlled release dosage form of embodiment 10, wherein the second matrix material comprises an average molecular weight of about 6,000, about 000 to 8, 000, 000 polyethylene oxide.

[0549] 12.实施方案6的固体控制释放剂型,其中所述第二基质材料中的所述聚环氧乙烷的平均分子量为约4, 000, 000至约10, 000, 000并且所述第一基质材料中的所述聚环氧乙烷的平均分子量为约300, 000至约3, 000, 000。 [0549] 12. The embodiment 6 of the solid controlled release dosage form, wherein the matrix material of the second polyethylene oxide average molecular weight of about 4,000, about 000 to 10, 000, 000 and the the first matrix material is polyethylene oxide average molecular weight of about 300, about 000 to 3, 000, 000.

[0550] 13.实施方案6的固体控制释放剂型,其中所述第二基质材料中的所述聚环氧乙烷的平均分子量为约6, 000, 000至约8, 000, 000并且所述第一基质材料中的所述聚环氧乙烷的平均分子量为约500, 000至约1,000, 000。 [0550] 13. The embodiment 6 of the solid controlled release dosage form, wherein the matrix material of the second polyethylene oxide average molecular weight of about 6,000, about 000 to 8, 000, 000 and the the first matrix material is polyethylene oxide of an average molecular weight of about 500, 000 to about 1,000, 000.

[0551] 14.实施方案1至13中任一项的固体控制释放剂型,其中所述核心与所述壳的重量比为约1 : 0. 5至约1 : 5。 [0551] 14. A solid embodiments 1 to 13 of a controlled release dosage form, wherein the weight ratio of core to the shell is from about 1: 0.5 to about 1: 5.

[0552] 15.实施方案14的固体控制释放剂型,其中所述核心与所述壳的重量比为约1 : 0· 6 至约I : L 5。 Solid [0552] Embodiment 15. A controlled release dosage form of embodiment 14, wherein the weight ratio of core to the shell is from about 1: 0.6 to about I: L 5.

[0553] 16.实施方案15的固体控制释放剂型,其中所述核心与所述壳的重量比为约1 : 0· 8 至约I : L 2。 [0553] 16. The embodiment 15 is solid controlled release dosage form, wherein the weight ratio of core to the shell is from about 1: 0.8 to about I: L 2.

[0554] 17.实施方案4的固体控制释放剂型,其中在所述第一基质材料中所述第一部分阿片样镇痛剂与聚环氧乙烷的重量比为约1 : 0.5至约1 : 100。 [0554] 17. The embodiment of the controlled release dosage form solid 4, wherein said first weight matrix material in the first portion of the opioid analgesic to polyethylene oxide ratio of about 1: 0.5 to about 1: 100.

[0555] 18.实施方案17的固体控制释放剂型,其中在所述第一基质材料中所述第一部分阿片样镇痛剂与聚环氧乙烷的重量比为约1 : 1至约1 : 10。 Solid [0555] Embodiment 18. The controlled release dosage form of embodiment 17, wherein said first weight matrix material in the first portion of the opioid analgesic to polyethylene oxide ratio of about 1: 1 to about 1: 10.

[0556] 19.实施方案18的固体控制释放剂型,其中在所述第一基质材料中所述第一部分阿片样镇痛剂与聚环氧乙烷的重量比为约1 : 1.5至约1 : 4。 [0556] Embodiment 19. The solid controlled release dosage form of embodiment 18, wherein said first weight matrix material in the first portion of the opioid analgesic to polyethylene oxide ratio of about 1: 1.5 to about 1: 4.

[0557] 20.实施方案5的固体控制释放剂型,其中在所述第二基质材料中所述第二部分阿片样镇痛剂与聚环氧乙烷的重量比为约1 : 2至约1 : 200。 [0557] 20. The embodiment 5 of the solid controlled release dosage form, wherein said second weight matrix material in the second portion of the opioid analgesic to polyethylene oxide ratio of about 1: 2 to about 1 : 200.

[0558] 21.实施方案20的固体控制释放剂型,其中在所述第二基质材料中所述第二部分阿片样镇痛剂与聚环氧乙烷的重量比为约1 : 5至约1 : 50。 [0558] Embodiment 21. The solid controlled release dosage form of embodiment 20, wherein said second weight matrix material in the second portion of the opioid analgesic to polyethylene oxide ratio of about 1: 5 to about 1 : 50.

[0559] 22.实施方案21的固体控制释放剂型,其中在所述第二基质材料中所述第二部分阿片样镇痛剂与聚环氧乙烷的重量比为约1 : 12至约1 : 25。 [0559] Embodiment 22. The solid controlled release dosage form of embodiment 21, wherein said second weight matrix material in the second portion of the opioid analgesic to polyethylene oxide ratio of about 1: 12 to about 1 : 25.

[0560] 23.实施方案1至22中任一项的固体控制释放剂型,其中所述第一部分中的所述阿片样镇痛剂与所述第二部分中的所述阿片样镇痛剂相同。 [0560] 23. A solid embodiments 1 to 22 of a controlled release dosage form, wherein the opioid same as in the first portion of said opioid analgesic and said second sample portion analgesic comp .

[0561] 24.实施方案1至22中任一项的固体控制释放剂型,其中所述第一部分中的阿片样镇痛剂与所述第二部分中的阿片样镇痛剂不同。 [0561] 24. A solid embodiments 1 to 22 of a controlled release dosage form, wherein the opioid analgesic in the first portion and the second portion of the opioid analgesic different.

[0562] 25.实施方案1至24中任一项的固体控制释放剂型,其中所述核心中阿片样镇痛剂与所述壳中阿片样镇痛剂的比率为约1 : 1至约10 : 1。 [0562] 25. A solid according to any one of embodiments 1 to 24 controls release dosage form, wherein the ratio of the opioid analgesic in the core and the shell opioid analgesic is from about 1: 1 to about 10 : 1.

[0563] 26.实施方案25的固体控制释放剂型,其中所述核心中阿片样镇痛剂与所述壳中阿片样镇痛剂的比率为约2 : 1至约8 : 1。 [0563] 26. The embodiment 25 is solid controlled release dosage form, wherein the ratio of the opioid analgesic in the core and the shell opioid analgesic is from about 2: 1 to about 8: 1.

[0564] 27.实施方案25的固体控制释放剂型,其中所述核心中阿片样镇痛剂与所述壳中阿片样镇痛剂的比率为约2 : 1至约5 : 1。 [0564] 27. The embodiment 25 is solid controlled release dosage form, wherein the ratio of the opioid analgesic in the core and the shell opioid analgesic is from about 2: 1 to about 5: 1.

[0565] 28.实施方案1至27中任一项的固体控制释放剂型,其中所述阿片样镇痛剂选自阿芬太尼、烯丙罗定、阿法罗定、阿尼利定、苄吗啡、贝齐米特、丁丙诺啡、布托啡诺、氯尼他秦、可待因、地索吗啡、右吗拉胺、地佐辛、地恩丙胺、二醋吗啡、双氢可待因、双氢吗啡、地美沙朵、地美庚醇、二甲噻丁、吗苯丁酯、地匹哌酮、依他佐辛、依索庚嗪、乙甲噻丁、乙基吗啡、依托尼秦、埃托啡、二氢埃托啡、芬太尼及衍生物、氢可酮、氢吗啡酮、羟哌替啶、异美沙酮、凯托米酮、左啡诺、左芬啡烷、洛芬太尼、哌替啶、美普他酚、美他佐辛、美沙酮、美托酮、 吗啡、麦罗啡、那碎因、尼可吗啡、去甲左啡诺、去甲美沙酮、烯丙吗啡、纳布啡、去甲吗啡、诺匹哌酮、阿片、羟考酮、羟吗啡酮、阿片全碱、喷他佐辛、苯吗庚酮、非诺啡烷、非那佐辛、苯哌 [0565] 28. A solid according to any one of embodiments 1-27 controlled release dosage form, wherein the opioid analgesic is selected from alfentanil, allyl Luoding, alphaprodine, anileridine, benzyl morphine, Beiqimite, buprenorphine, butorphanol, clonitazene, codeine, desomorphine, dextromoramide pull amines, dezocine, diampromide, diamorphine, dihydrocodeine may codeine, dihydrocodeine morphine, Methadone duo, the United States heptanol, dimethenamid-butoxy, it butyl benzene, to horses, risperidone, eptazocine, heptyl cable according oxazine, thiazole methyl acetate butyrate, ethyl morphine, etonitazene, etorphine, dihydroetorphine, fentanyl and derivatives, hydrocodone, hydromorphone, meperidine hydroxyalkyl, isobutyl methadone, ketobemidone, levorphanol, morphine left alkoxy Fen Los fentanyl, meperidine, meptazinol-, United States pentazocine, methadone, metopon, morphine, myrophine, narceine Nicole morphine, norepinephrine levorphanol, methadone norepinephrine, nalorphine, nalbuphine, normorphine, norpipanone, opium, oxycodone, oxymorphone, papaveretum, pentazocine, benzene it heptanone, non buprenorphine alkoxy, phenazocine benzene piperazine 定、匹米诺定、哌腈米特、普罗庚嘆、普鲁米多、丙哌利定、丙氧芬、舒芬太尼、替利定、曲马多、其可药用盐、其水合物、其溶剂合物、及其混合物。 Set, set horse minoxidil, piritramide, propheptazine sigh, multi promethazine, propyl piperazine vinzolidine, propoxyphene, sufentanil, tilidine, tramadol, pharmaceutically acceptable salts thereof, hydrates, solvates thereof, and mixtures thereof.

[0566] 29.实施方案28的固体控制释放剂型,其中所述阿片样镇痛剂选自可待因、氢可酮、氢吗啡酮、吗啡、羟考酮、羟吗啡酮、曲马多、其可药用盐、其水合物、其溶剂合物、及其混合物。 [0566] Embodiment 29. The solid controlled release dosage form of embodiment 28, wherein the opioid analgesic is selected from codeine, hydrocodone, hydromorphone, morphine, oxycodone, oxymorphone, tramadol, pharmaceutically acceptable salts, hydrates, solvates, and mixtures thereof.

[0567] 30.实施方案29的固体控制释放剂型,其中所述阿片样镇痛剂选自氢可酮、其可药用盐、其水合物、其溶剂合物、及其混合物。 [0567] 30. The embodiment 29 is solid controlled release dosage form, wherein the opioid analgesic is selected from hydrocodone, pharmaceutically acceptable salts, hydrates, solvates, and mixtures thereof.

[0568] 31.实施方案30的固体控制释放剂型,其中所述阿片样镇痛剂为重酒石酸氢可酮。 [0568] Embodiment 31. A solid controlled release dosage form of embodiment 30, wherein the opioid analgesic is hydrocodone bitartrate.

[0569] 32.实施方案31的固体控制释放剂型,其中重酒石酸氢可酮在所述剂型中的总量为约0· 5mg至约1250mg。 [0569] Embodiment 32. The solid controlled release dosage form of embodiment 31, wherein the hydrocodone bitartrate in the dosage form in total amount of about 0 · 5mg to about 1250mg.

[0570] 33.实施方案31的固体控制释放剂型,其中重酒石酸氢可酮在所述剂型中的总量为约2mg至约200mg。 [0570] Embodiment 33. A solid controlled release dosage form of embodiment 31, wherein the hydrocodone bitartrate in the total amount of the dosage form is from about 2mg to about 200mg.

[0571] 34.实施方案31的固体控制释放剂型,其中重酒石酸氢可酮在所述剂型中的总量为约16mg至约120mg。 [0571] Embodiment 34. A solid controlled release dosage form of embodiment 31, wherein the hydrocodone bitartrate in the total amount of the dosage form is from about 16mg to about 120mg.

[0572] 35.实施方案1至34中任一项的固体控制释放剂型,其中释放的阿片样镇痛剂的量在8至24小时与经过时间在10%内成比例。 The amount of opioid analgesic [0572] 35. The embodiments 1 to a solid controlled release dosage form of any one of 34, released at 8 to 24 hours elapsed time and to be in a ratio of 10%.

[0573] 36.实施方案35的固体控制释放剂型,其中释放的阿片样镇痛剂的量在8至24小时与经过时间在5%内成比例。 The amount of opioid analgesic [0573] 36. The embodiment 35 is solid controlled release dosage form, released at 8 to 24 hours elapsed time and to be in a proportion of 5%.

[0574] 37.实施方案1至34中任一项的固体控制释放剂型,其中释放的阿片样镇痛剂的量在8至18小时与经过时间在20%内成比例。 The amount of opioid analgesic [0574] 37. The embodiments 1 to a solid controlled release dosage form of any one of 34, released at 8 to 18 hours elapsed time and proportional to within 20%.

[0575] 38.实施方案1至34中任一项的固体控制释放剂型,其中释放的阿片样镇痛剂的量在8至12小时与经过时间在20%内成比例。 The amount of opioid analgesic [0575] 38. The embodiments 1 to a solid controlled release dosage form of any one of 34, released at 8 to 12 hours elapsed time and proportional to within 20%.

[0576] 39.实施方案1至34中任一项的固体控制释放剂型,其中释放的阿片样镇痛剂的量在12至24小时与经过时间在20%内成比例。 [0576] 39. The embodiments 1 to 34 in solid controlled release dosage form of any one of the amount of opioid analgesic released at 12 to 24 hours and is proportional to the elapsed time of 20%.

[0577] 40.实施方案1至34中任一项的固体控制释放剂型,其中释放的阿片样镇痛剂的量在12至18小时与经过时间在20%内成比例。 The amount of opioid analgesic [0577] 40. The embodiments 1 to a solid controlled release dosage form of any one of 34, released at 12 to 18 hours elapsed time and proportional to within 20%.

[0578] 41.实施方案37的固体控制释放剂型,其中释放的阿片样镇痛剂的量在8至18小时与经过时间在10%内成比例。 The amount of opioid analgesic [0578] 41. The embodiment 37 is solid controlled release dosage form, released at 8 to 18 hours elapsed time and to be in a ratio of 10%.

[0579] 42.实施方案38的固体控制释放剂型,其中释放的阿片样镇痛剂的量在8至12小时与经过时间在10%内成比例。 The amount of opioid analgesic [0579] 42. The embodiment 38 is solid controlled release dosage form, released at 8 to 12 hours elapsed time and to be in a ratio of 10%.

[0580] 43.实施方案39的固体控制释放剂型,其中释放的阿片样镇痛剂的量在12至24 小时与经过时间在10%内成比例。 The amount of opioid analgesic [0580] 43. The embodiment 39 is solid controlled release dosage form, released at 12 to 24 hours elapsed time and to be in a ratio of 10%.

[0581] 44.实施方案40的固体控制释放剂型,其中释放的阿片样镇痛剂的量在12至18 小时与经过时间在10%内成比例。 Solid [0581] Embodiment 44. The controlled release dosage form of embodiment 40, the amount of opioid analgesic released at 12 to 18 hours elapsed time and to be in a ratio of 10%.

[0582] 45.实施方案37的固体控制释放剂型,其中释放的阿片样镇痛剂的量在8至18小时与经过时间在5%内成比例。 The amount of opioid analgesic [0582] 45. The embodiment 37 is solid controlled release dosage form, released at 8 to 18 hours elapsed time and to be in a proportion of 5%.

[0583] 46.实施方案38的固体控制释放剂型,其中释放的阿片样镇痛剂的量在8至12小时与经过时间在5%内成比例。 The amount of opioid analgesic [0583] 46. The embodiment 38 is solid controlled release dosage form, released at 8 to 12 hours elapsed time and to be in a proportion of 5%.

[0584] 47.实施方案39的固体控制释放剂型,其中释放的阿片样镇痛剂的量在12至24 小时与经过时间在5%内成比例。 The amount of opioid analgesic [0584] 47. The embodiment 39 is solid controlled release dosage form, released at 12 to 24 hours elapsed time and to be in a proportion of 5%.

[0585] 48.实施方案40的固体控制释放剂型,其中释放的阿片样镇痛剂的量在12至18 小时与经过时间在5%内成比例。 Solid [0585] Embodiment 48. The controlled release dosage form of embodiment 40, the amount of opioid analgesic released at 12 to 18 hours elapsed time and to be in a proportion of 5%.

[0586] 49.实施方案1至48中任一项的固体控制释放剂型,其中在2小时时释放的阿片样镇痛剂的量小于约25%。 [0586] 49. The embodiments 1 to 48 in solid controlled release dosage form of any one of the amount of opioid analgesic released at 2 hours is less than about 25%.

[0587] 50.实施方案1至49中任一项的固体控制释放剂型,其中在4小时时释放的阿片样镇痛剂的量为约10 %至约30%。 [0587] 50. The embodiments 1 to 49 in solid controlled release dosage form according to any one of the amount of opioid analgesic released at 4 hours from about 10% to about 30%.

[0588] 51.实施方案1至50中任一项的固体控制释放剂型,其中在8小时时释放的阿片样镇痛剂的量为约20 %至约60%。 [0588] 51. The embodiments 1 to 50 in solid controlled release dosage form according to any one of the amount of opioid analgesic released at 8 hours about 20% to about 60%.

[0589] 52.实施方案1至51中任一项的固体控制释放剂型,其中在12小时时释放的阿片样镇痛剂的量为约40 %至约90%。 [0589] 52. The embodiments 1 to 51 in solid controlled release dosage form according to any one of the amount of opioid analgesic released at 12 hours from about 40% to about 90%.

[0590] 53.实施方案1至52中任一项的固体控制释放剂型,其中在18小时时释放的阿片样镇痛剂的量大于约70%。 [0590] 53. Solid embodiments 1 to 52 in any one of the controlled release dosage form, the amount of opioid analgesic released at 18 hours about 70%.

[0591] 54.实施方案1至53中任一项的固体控制释放剂型,其中在2小时时释放的阿片样镇痛剂的量小于约20%。 [0591] 54. The embodiments 1 to 53 in solid controlled release dosage form of any one of the amount of opioid analgesic released at 2 hours is less than about 20%.

[0592] 55.实施方案1至54中任一项的固体控制释放剂型,其中在4小时时释放的阿片样镇痛剂的量为约10 %至约20%。 [0592] 55. The solid of embodiments 1 to 54 in any one of the controlled release dosage form, the amount of opioid analgesic released at 4 hours from about 10% to about 20%.

[0593] 56.实施方案1至55中任一项的固体控制释放剂型,其中在8小时时释放的阿片样镇痛剂的量为约20 %至约40%。 [0593] 56. The embodiments 1 to 55 in solid controlled release dosage form according to any one of the amount of opioid analgesic released at 8 hours about 20% to about 40%.

[0594] 57.实施方案1至56中任一项的固体控制释放剂型,其中在12小时时释放的阿片样镇痛剂的量为约40 %至约65%。 [0594] 57. The embodiments 1 to 56 in solid controlled release dosage form according to any one of the amount of opioid analgesic released at 12 hours from about 40% to about 65%.

[0595] 58.实施方案1至57中任一项的固体控制释放剂型,其中在18小时时释放的阿片样镇痛剂的量大于约80%。 [0595] 58. A solid embodiment 1-57 of any one controlled release dosage form, the amount of opioid analgesic released at 18 hours about 80%.

[0596] 59.实施方案1至58中任一项的固体控制释放剂型,其中在2小时时释放的阿片样镇痛剂的量小于约15%。 [0596] 59. A solid embodiment 1-58 of any one controlled release dosage form, the amount of opioid analgesic released at 2 hours is less than about 15%.

[0597] 60.实施方案1至59中任一项的固体控制释放剂型,其中在4小时时释放的阿片样镇痛剂的量为约20 %至约30%。 [0597] 60. The embodiments 1 to 59 in solid controlled release dosage form according to any one of the amount of opioid analgesic released at 4 hours from about 20% to about 30%.

[0598] 61.实施方案1至60中任一项的固体控制释放剂型,其中在8小时时释放的阿片样镇痛剂的量为约45 %至约60%。 [0598] 61. The embodiments according to the solid controlled release dosage form of 1 to 60, the amount of opioid analgesic released at 8 hours about 45% to about 60%.

[0599] 62.实施方案1至61中任一项的固体控制释放剂型,其中在12小时时释放的阿片样镇痛剂的量为约70 %至约90%。 [0599] 62. The embodiments 1 to 61 in solid controlled release dosage form according to any one of the amount of opioid analgesic released at 12 hours was about 70% to about 90%.

[0600] 63.实施方案1至62中任一项的固体控制释放剂型,其中在18小时时释放的阿片样镇痛剂的量大于约90%。 [0600] 63. The embodiments 1 to 62 in solid controlled release dosage form of any one of, a large amount of opioid analgesic released at 18 hours is about 90%.

[0601] 64.实施方案6的固体控制释放剂型,其中在至少所述聚环氧乙烷之软化点的温度下所述剂型熟化至少1分钟。 [0601] 64. The embodiment 6 of the solid controlled release dosage form, wherein the dosage form is cured at a softening point of said polyethylene oxide at least a temperature of at least 1 minute.

[0602] 65.实施方案6的固体控制释放剂型,其中在至少所述聚环氧乙烷之软化点的温度下所述剂型熟化至少5分钟。 [0602] 65. The embodiment 6 of the solid controlled release dosage form, wherein the dosage form is cured at a softening point of said polyethylene oxide at least a temperature of at least 5 minutes.

[0603] 66.实施方案6的固体控制释放剂型,其中在至少所述聚环氧乙烷之软化点的温度下所述剂型熟化至少15分钟。 [0603] 66. The embodiment 6 of the solid controlled release dosage form, wherein the dosage form is cured at a softening point of said polyethylene oxide at least a temperature of at least 15 minutes.

[0604] 67.实施方案6的固体控制释放剂型,其中在至少所述聚环氧乙烷之软化点的温度下所述剂型熟化约1分钟至约48小时。 [0604] 67. The embodiment 6 of the solid controlled release dosage form, wherein the dosage form is cured at a softening point of said polyethylene oxide at least a temperature of from about 1 minute to about 48 hours.

[0605] 68.实施方案6的固体控制释放剂型,其中在至少所述聚环氧乙烷之软化点的温度下所述剂型熟化约5分钟至约24小时。 [0605] 68. The embodiment 6 of the solid controlled release dosage form, wherein the dosage form is cured at a softening point of said polyethylene oxide at least a temperature of about 5 minutes to about 24 hours.

[0606] 69.实施方案6的固体控制释放剂型,其中在至少所述聚环氧乙烷之软化点的温度下所述剂型熟化约15分钟至约1小时。 [0606] 69. The embodiment 6 of the solid controlled release dosage form, wherein the dosage form is cured at a softening point of said polyethylene oxide at least a temperature of from about 15 minutes to about 1 hour.

[0607] 70.实施方案64至69中任一项的固体控制释放剂型,其中在至少约60°C的温度下所述剂型熟化。 [0607] 70. The solid 64-69 embodiment of any one controlled release dosage form, wherein at least at a temperature of 60 ° C to about the dosage form is cured.

[0608] 71.实施方案64至69中任一项的固体控制释放剂型,其中在至少约65°C的温度下所述剂型熟化。 [0608] 71. A solid 64-69 embodiment of any one controlled release dosage form, wherein the temperature of at least about 65 ° C in the dosage form is cured.

[0609] 72.实施方案64至69中任一项的固体控制释放剂型,其中在至少约70°C的温度下所述剂型熟化。 [0609] 72. A solid 64-69 embodiment of any one controlled release dosage form, wherein the temperature of at least about 70 ° C in the dosage form is cured.

[0610] 73.实施方案64至69中任一项的固体控制释放剂型,其中在至少约75°C的温度下所述剂型熟化。 [0610] 73. The solid 64-69 embodiment of any one controlled release dosage form, wherein the temperature of at least about 75 ° C in the dosage form is cured.

[0611] 74.实施方案64至69中任一项的固体控制释放剂型,其中在约72°C的温度下所述剂型熟化。 [0611] 74. The solid 64-69 embodiment of any one controlled release dosage form, wherein at a temperature of about 72 ° C in the dosage form is cured.

[0612] 75.实施方案64至69中任一项的固体控制释放剂型,其中在约60°C至约90°C的温度下所述剂型熟化。 [0612] 75. A solid 64-69 embodiment of any one controlled release dosage form, wherein at about 60 ° C to about the dosage form is cured at a temperature of 90 ° C.

[0613] 76.实施方案64至69中任一项的固体控制释放剂型,其中在约65°C至约85°C的温度下所述剂型熟化。 [0613] 76. A solid 64-69 embodiment of any one controlled release dosage form, wherein about 65 ° C to about the dosage form is cured at a temperature of 85 ° C.

[0614] 77.实施方案64至69中任一项的固体控制释放剂型,其中在约70°C至约80°C的温度下所述剂型熟化。 [0614] 77. The solid 64-69 embodiment of any one controlled release dosage form, wherein at about 70 ° C and the dosage form is cured at a temperature of about to 80 ° C.

[0615] 78.实施方案64至69中任一项的固体控制释放剂型,其中在约75°C至约80°C的温度下所述剂型熟化。 [0615] 78. The solid 64-69 embodiment of any one controlled release dosage form, wherein about 75 ° C to about the dosage form is cured at a temperature to 80 ° C.

[0616] 79.实施方案64至69中任一项的固体控制释放剂型,其中在约70°C至约75°C的温度下所述剂型熟化。 [0616] 79. The solid 64-69 embodiment of any one controlled release dosage form, wherein at about 70 ° C and the dosage form is cured at a temperature of about 75 ° C.

[0617] 80.实施方案1至79中任一项的固体控制释放剂型,其中所述核心和所述壳在视觉上不可区分。 [0617] 80. A solid embodiment 1-79 of any one controlled release dosage form, wherein the core and the shell is indistinguishable visually.

[0618] 81.实施方案1至79中任一项的固体控制释放剂型,其中所述核心和所述壳具有彼此10%以内的CIE L * A * B *值。 [0618] 81. A solid embodiment 1-79 of any one controlled release dosage form, wherein the core and the shell having a CIE L * A * B * values ​​within 10% of each other.

[0619] 82.实施方案1至81中任一项的固体控制释放剂型,其中所述剂型可被压扁而不破碎,其中被压扁后所述剂型的厚度相当于被压扁前所述剂型厚度的不超过约60%。 [0619] 82. The embodiments 1 to 81 in solid controlled release dosage form of any one, wherein the dosage form can be flattened without breaking, wherein after the flattening which corresponds to the thickness of the dosage form before flattening the the thickness of the dosage form does not exceed about 60%.

[0620] 83.实施方案82的固体控制释放剂型,其中所述剂型可被压扁而不破碎,其中被压扁后所述剂型的厚度相当于被压扁前所述剂型厚度的不超过约50%。 [0620] 83. The embodiment 82 is solid controlled release dosage form, wherein the dosage form can be flattened without breaking, wherein a thickness of the dosage form after the flattening which corresponds to no more than the dosage form before flattening, a thickness of about 50%.

[0621] 84.实施方案82的固体控制释放剂型,其中所述剂型可被压扁而不破碎,其中被压扁后所述剂型的厚度相当于被压扁前所述剂型厚度的不超过约40%。 [0621] 84. The embodiment 82 is solid controlled release dosage form, wherein the dosage form can be flattened without breaking, wherein a thickness of the dosage form after the flattening which corresponds to no more than the dosage form before flattening, a thickness of about 40%.

[0622] 85.实施方案82的固体控制释放剂型,其中所述剂型可被压扁而不破碎,其中被压扁后所述剂型的厚度相当于被压扁前所述剂型厚度的不超过约30%。 [0622] 85. The embodiment 82 is solid controlled release dosage form, wherein the dosage form can be flattened without breaking, wherein a thickness of the dosage form after the flattening which corresponds to the dosage form before flattening a thickness no more than about 30%.

[0623] 86.实施方案82的固体控制释放剂型,其中所述剂型可被压扁而不破碎,其中被压扁后所述剂型的厚度相当于被压扁前所述剂型厚度的不超过约20%。 [0623] 86. The embodiment 82 is solid controlled release dosage form, wherein the dosage form can be flattened without breaking, wherein a thickness of the dosage form after the flattening which corresponds to no more than the dosage form before flattening, a thickness of about 20%.

[0624] 87.实施方案82至86中任一项的固体控制释放剂型,其中,如通过在USP装置1(篮)中以IOOrpm在37°C下于900ml不含酶的模拟胃液(SGF)中体外溶出所测量的, 在0. 5小时时从被压扁剂型释放的阿片样镇痛剂的量与未被压扁剂型相比偏差不超过约20% 点。 [0624] 87. The solid embodiments 82 to 86 of any one controlled release dosage form, wherein, as measured by (the basket) to IOOrpm 900ml simulated gastric fluid without enzymes at 37 ° C for at in a USP Apparatus 1 (SGF) in vitro dissolution is measured at 0.5 hours from the flattened release opioid analgesic dosage amount dosage compared to the non flattening deviation of less than about 20% points.

[0625] 88.实施方案82至86中任一项的固体控制释放剂型,其中,如通过在USP装置1(篮)中以IOOrpm在37°C下于900ml不含酶的模拟胃液(SGF)中体外溶出所测量的, 在0. 5小时时从被压扁剂型释放的阿片样镇痛剂的量与未被压扁剂型相比偏差不超过约15% 点。 [0625] 88. A solid embodiment 86 embodiment 82 according to the controlled release dosage form, wherein, as measured by (the basket) to IOOrpm 900ml simulated gastric fluid without enzymes at 37 ° C for at in a USP Apparatus 1 (SGF) in vitro dissolution is measured at 0.5 hours from the flattened release opioid analgesic dosage amount dosage compared to the non flattening deviation does not exceed about 15% points.

[0626] 89.实施方案82至86中任一项的固体控制释放剂型,其中,如通过在USP装置1(篮)中以IOOrpm在37°C下于900ml不含酶的模拟胃液(SGF)中体外溶出所测量的, 在0. 5小时时从被压扁剂型释放的阿片样镇痛剂的量与未被压扁剂型相比偏差不超过约10% 点。 [0626] 89. A solid embodiment 86 embodiment 82 according to the controlled release dosage form, wherein, as measured by (the basket) to IOOrpm 900ml simulated gastric fluid without enzymes at 37 ° C for at in a USP Apparatus 1 (SGF) in vitro dissolution is measured at 0.5 hours from the flattened release opioid analgesic dosage amount dosage compared to the non flattening deviation does not exceed about 10% points.

[0627] 90.实施方案30的固体控制释放剂型,其在施用后提供约0. 55至约I. 0的氢可酮的cM/cmax比率。 [0627] 90. The embodiment 30 is solid controlled release dosage form, which provides cM / cmax ratio of from about 0.55 to about 0. I. hydrogen oxycodone after administration.

[0628] 91.实施方案90的固体控制释放剂型,其中所述C24/Cmax比率为约0. 55至约0. 85。 [0628] 91. The embodiment 90 is solid controlled release dosage form, wherein the C24 / Cmax ratio of from about 0.55 to about 0.85.

[0629] 92.实施方案90的固体控制释放剂型,其中所述C24/Cmax比率为约0. 55至约0. 75。 [0629] 92. The embodiment 90 is solid controlled release dosage form, wherein the C24 / Cmax ratio of from about 0.55 to about 0.75.

[0630] 93.实施方案90的固体控制释放剂型,其中所述C24/Cmax比率为约0. 60至约0. 70。 [0630] 93. The embodiment 90 is solid controlled release dosage form, wherein the C24 / Cmax ratio of from about 0.60 to about 0.70.

[0631] 94.实施方案30的固体控制释放剂型,其在施用后提供约4至约20小时的氢可酮的Tmax(h)。 [0631] 94. The embodiment 30 is solid controlled release dosage form, which provides a Tmax (h) from about 4 to about 20 hours hydrocodone after administration.

[0632] 95.实施方案94的固体控制释放剂型,其中所述Tmax (h)为约6至约12小时。 [0632] 95. The embodiment 94 is solid controlled release dosage form, wherein the Tmax (h) is from about 6 to about 12 hours.

[0633] 96.实施方案94的固体控制释放剂型,其中所述Tmax (h)为约8至约10小时。 [0633] 96. The embodiment 94 is solid controlled release dosage form, wherein the Tmax (h) is from about 8 to about 10 hours.

[0634] 97.实施方案94的固体控制释放剂型,其中所述Tmax (h)为约4至约10小时。 [0634] 97. The embodiment 94 is solid controlled release dosage form, wherein the Tmax (h) is from about 4 to about 10 hours.

[0635] 98.实施方案94的固体控制释放剂型,其中所述Tmax (h)为约8至约14小时。 [0635] 98. The embodiment 94 is solid controlled release dosage form, wherein the Tmax (h) is from about 8 to about 14 hours.

[0636] 99.实施方案94的固体控制释放剂型,其中,在施用所述剂型后,所述TmmaxQi)为约14至约20小时。 [0636] 99. The embodiment 94 is solid controlled release dosage form, wherein the dosage form after administration, the TmmaxQi) ​​is from about 14 to about 20 hours.

[0637] 100.实施方案90至99中任一项的固体控制释放剂型,其中所述施用为向健康对象的首次施用。 [0637] 100. The embodiments 90 to 99 in solid controlled release dosage form of any one of, wherein the administration is a first administration to healthy subjects.

[0638] 101.实施方案90至99中任一项的固体控制释放剂型,其中所述施用为向健康对象之群体的首次施用。 [0638] 101. The embodiments 90 to 99 in solid controlled release dosage form of any one of, wherein the administration is a first administration to a population of healthy subjects.

[0639] 102.实施方案90至99中任一项的固体控制释放剂型,其中所述施用为向健康对象的稳态施用。 [0639] 102. The embodiments 90 to 99 in solid controlled release dosage form of any one of, wherein said administration is steady state administration to healthy subjects.

[0640] 103.实施方案90至99中任一项的固体控制释放剂型,其中所述施用为向健康对象之群体的稳态施用。 [0640] 103. The embodiments 90 to 99 in solid controlled release dosage form of any one of, wherein said administration is steady state administration to healthy subjects of the population.

[0641] 104.实施方案30的固体控制释放剂型,其含有约20mg氢可酮或其可药用盐。 [0641] Embodiment 30. 104. The solid controlled release dosage form containing from about 20mg hydrocodone or a pharmaceutically acceptable salt thereof.

[0642] 105.实施方案30的固体控制释放剂型,其含有约120mg氢可酮或其可药用盐。 [0642] 105. The embodiment 30 is solid controlled release dosage form, comprising from about 120mg hydrocodone or a pharmaceutically acceptable salt thereof.

[0643] 106.实施方案30的固体控制释放剂型,其在施用后每20mg包含在所述剂型中的氢可酮提供约250至400的平均AUC(ng * h/mL)。 [0643] 106. The embodiment 30 is solid controlled release dosage form, each of 20mg of the hydrogen contained in the dosage form provides a mean AUC may be one of about 250 to 400 (ng * h / mL) after administration.

[0644] 107.实施方案104的固体控制释放剂型,其在施用后提供约250至约400、约275 至约350、约300至330或约280至约320的平均AUC (ng * h/mL)。 [0644] 107. The embodiment 104 of a solid controlled release dosage form which provides from about 250 to about 400 after administration, from about 275 to about 350, an average AUC of about 300 to 330 or about 280 to about 320 (ng * h / mL ).

[0645] 108.实施方案105的固体控制释放剂型,其在施用后提供约1500至约2400、约1700 至约2200、约1800 至约2100 或约1900 至约2100 的平均AUC (ng * h/mL)。 [0645] 108. The embodiment 105 of a solid controlled release dosage form to provide from about 1500 to about 2400 after administration, from about 1700 to about 2200, an average AUC of about 1800 to about 2100 or from about 1900 to about 2100 (ng * h / mL).

[0646] 109.实施方案30的固体控制释放剂型,其在施用后每20mg包含在所述剂型中的氢可酮提供约10至约30的平均Cniax (ng/mL)。 [0646] Embodiment 30. 109. The solid controlled release dosage form, each of 20mg of the hydrogen contained in the dosage form may provide one Cniax average of from about 10 to about 30 (ng / mL) after administration.

[0647] 110.实施方案104的固体控制释放剂型,其在施用后提供约10至约30、约12至约25、约14至约18或约12至约17的平均Cniax (ng/mL)。 [0647] 110. The embodiment 104 of a solid controlled release dosage form which provides from about 10 to about 30 after administration, about 12 to about 25, from about 14 to about 18, or about 12 to about an average of 17 Cniax (ng / mL) .

[0648] 111.实施方案105的固体控制释放剂型,其在施用后提供约60至约180、约100 至约160、约110至约150或约100至约140的平均Cniax (ng/mL)。 [0648] 111. The embodiment 105 of a solid controlled release dosage form which provides from about 60 to about 180 after administration, from about 100 to about 160, from about 110 to about 150, or from about 100 to about Cniax an average of 140 (ng / mL) .

[0649] 112.实施方案30的固体控制释放剂型,其在施用后提供约10至约20、约12至约18、约13至约17或约14至约16的平均T_(h)。 [0649] Embodiment 30. 112. The solid controlled release dosage form to provide from about 10 to about 20 after administration, about 12 to about 18, an average T_ (h) from about 13 to about 17, or about 14 to about 16.

[0650] 113.实施方案30的固体控制释放剂型,其在施用后提供约5至约10、约6至约9、 约7或约8的平均T1/2 (h)。 [0650] 113. The embodiment 30 is solid controlled release dosage form which provides from about 5 to about 10, from about 6 to about 9 after administration, the average T1 of about 7, or about 8/2 (h).

[0651] 114.实施方案30的固体控制释放剂型,其在施用后提供约0. 01至约0. 2、约0. 1 至约0· 18、约0· 3至约0· 17或约0· 06至约0· 15的平均TlagQi)。 [0651] Embodiment 30. 114. The solid controlled release dosage form to provide from about 0.01 to about 0.2 after administration, about 0.1 to 18 about 0.5, from about 0.5 to about 3, or from about 0 · 17 the average TlagQi 0 · 06 to about 0 · 15).

[0652] 115.实施方案30的固体控制释放剂型,其中所述平均C24/Cmax比率为约0. 2至约0. 8、约0. 3至约0. 7或约0. 4至约0. 6。 [0652] Embodiment 30. 115. The solid controlled release dosage form, wherein the mean C24 / Cmax ratio of from about 0.2 to about 0.8, from about 0.3 to about 0.7, or about 0.4 to about 0 6.

[0653] 116.实施方案106至115中任一项的固体控制释放剂型,其中在禁食状态下进行施用。 [0653] 116. The embodiment 106 to 115 solid controlled release dosage form of any one, which is administered in the fasted state.

[0654] 117.实施方案30的固体控制释放剂型,其中在进食状态下施用后所述平均AUC(ng * h/mL)比在禁食状态下施用后所述AUC(ng * h/mL)高出不到20%、不到16%或不到12%。 [0654] Embodiment 117. The solid controlled release dosage form of embodiment 30, wherein said after administration in the fed state mean AUC (ng * h / mL) than after administration in the fasted state AUC (ng * h / mL) higher than 20%, less than 16% or less than 12%.

[0655] 118.实施方案30的固体控制释放剂型,其中在进食状态下施用后所述平均Cmax (ng/mL)比在禁食状态下施用后所述Cmax (ng/mL)高出不到80 %、不到70 %或不到60 %。 [0655] Embodiment 30. 118. The solid controlled release dosage form, wherein the mean Cmax (ng / mL) after administration in the fed state than after administration in the fasted state Cmax (ng / mL) than higher 80%, less than 70%, or less than 60%.

[0656] 119.实施方案30的固体控制释放剂型,其中在进食状态下施用后所述平均TmaxOi)为在禁食状态下施用后所述TmaxOO的25%以内、20%以内或15%以内。 [0656] Embodiment 119. The solid controlled release dosage form of embodiment 30, wherein the average TmaxOi after administration in the fed state) is within 25% in the fasted state after administration of the TmaxOO, within 20% or within 15%.

[0657] 120.实施方案30的固体控制释放剂型,其中在进食状态下施用后所述平均T1/2(h)为在禁食状态下施用后所述T1/2(h)的8%以内、5%以内或2%以内。 [0657] Embodiment 30. 120. The solid controlled release dosage form, wherein after administration in the fed state average T1 / 2 (h) is within in the fasted state after administration of the T1 / 2 (h) of 8% , within 5% or within 2%.

[0658] 121.实施方案30的固体控制释放剂型,其中在进食状态下施用后所述平均TlagQi)比在禁食状态下施用后所述T1/2高出不到150%、不到125%或不到100%。 [0658] Embodiment 30. 121. The solid controlled release dosage form, wherein after administration in the fed state the average TlagQi) is less than 150% higher than the T1 / 2 after administration in the fasted state, is less than 125% or less than 100%.

[0659] 122. -种固体控制释放剂型,其包含: [0659] 122. - one solid controlled release dosage form, comprising:

[0660] 核心,其包含分散在包含聚环氧乙烧之第一基质材料中的第一部分阿片样镇痛剂;和 [0660] core, the first portion comprising an opioid analgesic dispersed in a first matrix material comprises polyethylene oxide in the burning; and

[0661] 壳,其包覆所述核心并且包含分散在包含聚环氧乙烷之第二基质材料中的第二部分所述阿片样镇痛剂。 [0661] shell, which covers the core and comprising a second portion of the opioid analgesic dispersed in a second matrix material comprises polyethylene oxide in.

[0662] 123. -种固体控制释放剂型,其包含: [0662] 123. - one solid controlled release dosage form, comprising:

[0663] 压制核心,其包含分散在包含聚环氧乙烧之第一基质材料中的第一部分阿片样镇痛剂;和 [0663] compressed core comprising a first portion opioid analgesic dispersed in a first matrix material comprises polyethylene oxide in the burning; and

[0664] 压制包衣,其包覆所述核心并且包含分散在包含聚环氧乙烷之第二基质材料中的第二部分所述阿片样镇痛剂。 [0664] compression coating, which covers the core and comprising a second portion of the opioid analgesic dispersed in a second matrix material comprises polyethylene oxide in.

[0665] 124. -种固体控制释放剂型,其包含: [0665] 124. - one solid controlled release dosage form, comprising:

[0666] 核心,其包含分散在第一基质材料中的第一部分阿片样镇痛剂;和 [0666] core, the first portion comprising an opioid analgesic dispersed in a first matrix material; and

[0667] 壳,其包覆所述核心并且包含分散在第二基质材料中的第二部分所述阿片样镇痛剂; [0667] shell, which covers the core and comprising a second portion of the opioid analgesic dispersed in a second matrix material;

[0668] 其中,如通过在USP装置1(篮)中以IOOrpm在37°C下于900ml不含酶的模拟胃液(SGF)中体外溶出所测量的, [0668] wherein, as measured by the USP Apparatus 1 (basket) at IOOrpm at 37 ° C for 900ml simulated gastric fluid without enzymes (SGF) measured in vitro dissolution,

[0669] 在2小时时从所述剂型释放的阿片样镇痛剂的量小于约25% ; [0669] 2 hours in an amount of opioid analgesic from the dosage form releases less than about 25%;

[0670] 在4小时时从所述剂型释放的阿片样镇痛剂的量为约10%至约30% ; Amount [0670] of opioid analgesic released at 4 hours from the dosage form is from about 10% to about 30%;

[0671] 在8小时时从所述剂型释放的阿片样镇痛剂的量为约20%至约60% ; Amount [0671] of opioid analgesic released at 8 hours from the dosage form is from about 20% to about 60%;

[0672] 在12小时时从所述剂型释放的阿片样镇痛剂的量为约40%至约90% ;并且 Amount [0672] of opioid analgesic released at 12 hours from the dosage form is from about 40% to about 90%; and

[0673] 在18小时时从所述剂型释放的阿片样镇痛剂的量大于约70%。 [0673] amount of opioid analgesic released at 18 hours from the dosage form in about 70%.

[0674] 125. -种固体控制释放剂型,其包含: [0674] 125. - one solid controlled release dosage form, comprising:

[0675] 治疗有效量的氢可酮或其可药用盐,和控制释放赋形剂; [0675] a therapeutically effective amount of hydrocodone or a pharmaceutically acceptable salt thereof, and controlled release excipient;

[0676] 其中,如通过在USP装置1(篮)中以IOOrpm在37°C下于900ml不含酶的模拟胃液(SGF)中体外溶出所测量的,从所述剂型释放的氢可酮或其盐的量在8至24小时与经过时间在20%内成比例;并且 [0676] wherein, as measured by USP Apparatus 1 (basket) to IOOrpm at 37 ° C for 900ml simulated gastric fluid without enzymes (SGF) as measured in vitro dissolution, release from the dosage form in or hydrocodone a salt thereof in an amount of from 8 to 24 hours elapsed time and 20% by proportional; and

[0677] 所述剂型可被压扁而不破碎,其中被压扁后所述剂型的厚度相当于被压扁前所述剂型厚度的不超过约20% ;并且 [0677] The dosage form can be flattened without breaking, wherein a thickness of the dosage form after the flattening which corresponds to no more than about 20% of the thickness before flattening the dosage form; and

[0678] 如通过在USP装置1(篮)中以IOOrpm在37°C下于900ml不含酶的模拟胃液(SGF) 中体外溶出所测量的,在〇. 5小时时从被压扁剂型释放的氢可酮或其盐的量与未被压扁剂型相比偏差不超过约20%点。 [0678] The IOOrpm by 900ml simulated gastric fluid without enzymes (SGF) as dissolution in vitro at 37 ° C for measured in a USP Apparatus 1 (basket), and when the square. 5 hours released from the dosage form is crushed the hydrocodone or salt thereof and the amount of dosage form as compared to non-flattening deviation of less than about 20% points.

[0679] 126. -种固体控制释放剂型,其包含: [0679] 126. - one solid controlled release dosage form, comprising:

[0680] 治疗有效量的氢可酮或其可药用盐,和控制释放赋形剂; [0680] a therapeutically effective amount of hydrocodone or a pharmaceutically acceptable salt thereof, and controlled release excipient;

[0681] 其中,如通过在USP装置1(篮)中以IOOrpm在37°C下于900ml不含酶的模拟胃液(SGF)中体外溶出所测量的, [0681] wherein, as measured by the USP Apparatus 1 (basket) at IOOrpm at 37 ° C for 900ml simulated gastric fluid without enzymes (SGF) measured in vitro dissolution,

[0682] 在2小时时从所述剂型释放的氢可酮或其盐的量小于约25% ; [0682] at 2 hours is released from the dosage form of hydrocodone or salt thereof is less than about 25%;

[0683] 在4小时时从所述剂型释放的氢可酮或其盐的量为约10%至约30% ; [0683] at 4 hours released from the dosage form of hydrocodone or salt thereof from about 10% to about 30%;

[0684] 在8小时时从所述剂型释放的氢可酮或其盐的量为约20%至约60% ; The amount of [0684] is released at 8 hours from the dosage form of hydrocodone or a salt thereof is from about 20% to about 60%;

[0685] 在12小时时从所述剂型释放的氢可酮或其盐的量为约40%至约90% ;和 [0685] at 12 hours released from the dosage form of hydrocodone or salt thereof from about 40% to about 90%; and

[0686] 在18小时时从所述剂型释放的氢可酮或其盐的量大于约70% ; [0686] at 18 hours released from the dosage form of hydrocodone or a salt thereof is greater than about 70%;

[0687] 并且 [0687] and

[0688] 所述剂型可被压扁而不破碎,其中被压扁后所述剂型的厚度相当于被压扁前所述剂型厚度的不超过约20% ;并且 [0688] The dosage form can be flattened without breaking, wherein a thickness of the dosage form after the flattening which corresponds to no more than about 20% of the thickness before flattening the dosage form; and

[0689] 如通过在USP装置1(篮)中以IOOrpm在37°C下于900ml不含酶的模拟胃液(SGF) 中体外溶出所测量的,在〇. 5小时时从被压扁剂型释放的氢可酮或其盐的量与未被压扁剂型相比偏差不超过约20%点。 [0689] The IOOrpm by 900ml simulated gastric fluid without enzymes (SGF) as dissolution in vitro at 37 ° C for measured in a USP Apparatus 1 (basket), and when the square. 5 hours released from the dosage form is crushed the hydrocodone or salt thereof and the amount of dosage form as compared to non-flattening deviation of less than about 20% points.

[0690] 127. -种固体控制释放剂型,其包含: [0690] 127. - one solid controlled release dosage form, comprising:

[0691] 分散在控制释放赋形剂中的治疗有效量的氢可酮或其可药用盐;其中所述剂型的内部60 %含有至少80 %的所述氢可酮或其盐; [0691] dispersed in a controlled release excipient therapeutically effective amount of hydrocodone or a pharmaceutically acceptable salt thereof; wherein the interior of the dosage form comprises at least 80% to 60% of the hydrocodone or salt thereof;

[0692] 其中,如通过在USP装置1(篮)中以IOOrpm在37°C下于900ml不含酶的模拟胃液(SGF)中体外溶出所测量的,从所述剂型释放的氢可酮或其盐的量在8至24小时与经过时间在20%内成比例。 [0692] wherein, as measured by USP Apparatus 1 (basket) to IOOrpm at 37 ° C for 900ml simulated gastric fluid without enzymes (SGF) as measured in vitro dissolution, release from the dosage form in or hydrocodone a salt thereof in an amount of from 8 to 24 hours elapsed time and within 20% in proportion.

[0693] 128.实施方案127的固体控制释放剂型,其中所述剂型的内部50%含有至少80% 的所述氢可酮或其盐。 [0693] 128. The embodiment 127 of a solid controlled release dosage form, wherein the interior of the dosage form comprises at least 80% to 50% of the hydrocodone or salt thereof.

[0694] 129. -种在有此需要的对象中治疗疼痛的方法,其包括向所述对象施用根据实施方案1至128中任一项的固体控制释放剂型。 [0694] 129. - methods of treating pain in a subject in need thereof, which comprises administering a solid 1-128 any of controlled release dosage form according to the subject embodiment.

[0695] 130. -种制备固体控制释放剂型的方法,其包括: [0695] 130. - The method of preparing a solid kind of controlled release dosage form, comprising:

[0696] 制备核心,所述核心包含分散在第一基质材料中的第一部分阿片样镇痛剂;和 [0696] Preparation of the core, the core comprising a first portion opioid analgesic dispersed in a first matrix material; and

[0697] 用壳包覆所述核心,所述壳包含分散在第二基质材料中的第二部分所述阿片样镇痛剂; [0697] coating the core with a shell, said shell comprising a second portion of the opioid analgesic dispersed in a second matrix material;

[0698] 其中,如通过在USP装置1(篮)中以IOOrpm在37°C下于900ml不含酶的模拟胃液(SGF)中体外溶出所测量的,从所述剂型释放的阿片样镇痛剂的量在8至24小时与经过时间在20%内成比例。 [0698] wherein, as measured by the USP Apparatus 1 (basket) at IOOrpm at 37 ° C for 900ml simulated gastric fluid without enzymes (SGF) as measured in vitro dissolution, releases the opioid analgesic from the dosage form agent in an amount of from 8 to 24 hours elapsed time and to be in a proportion of 20%.

[0699] 131. -种制备固体控制释放剂型的方法,其包括: [0699] 131. - The method of preparing a solid kind of controlled release dosage form, comprising:

[0700] 制备核心,所述核心包含分散在包含聚环氧乙烷之第一基质材料中的第一部分阿片样镇痛剂;和 [0700] Preparation of the core, the core comprising a first portion opioid analgesic dispersed in a first matrix material comprising a polyethylene oxide in; and

[0701] 将所述核心包覆在壳中,所述壳包含分散在包含聚环氧乙烷之第二基质材料中的第二部分所述阿片样镇痛剂。 [0701] The coated core shell, said shell comprising a second portion of the opioid analgesic dispersed in a second matrix material comprises polyethylene oxide in.

[0702] 132. -种制备固体控制释放剂型的方法,其包括: [0702] 132. - The method of preparing a solid kind of controlled release dosage form, comprising:

[0703] 制备压制核心,所述核心包含分散在包含聚环氧乙烷之第一基质材料中的第一部分阿片样镇痛剂;和 [0703] Preparation of compressed core, the core comprising a first portion opioid analgesic dispersed in a first matrix material comprising a polyethylene oxide in; and

[0704] 通过在所述核心上以分散在包含聚环氧乙烷之第二基质材料中的第二部分所述阿片样镇痛剂压制包衣来包覆所述核心。 [0704] By the core comprises polyethylene dispersed in the matrix material of the second portion of the second ethane in the opioid analgesic coated press-coated to the core.

[0705] 133. -种制备固体控制释放剂型的方法,其包括: [0705] 133. - The method of preparing a solid kind of controlled release dosage form, comprising:

[0706] 制备核心,所述核心包含分散在第一基质材料中的第一部分阿片样镇痛剂;和 [0706] Preparation of the core, the core comprising a first portion opioid analgesic dispersed in a first matrix material; and

[0707] 将所述核心包覆在壳中,所述壳包含分散在所述核心上之第二基质材料中的第二部分所述阿片样镇痛剂; [0707] The coated core shell, said shell comprising a second portion of the second material is dispersed in the matrix of the core of the opioid analgesic;

[0708] 其中,如通过在USP装置1(篮)中以IOOrpm在37°C下于900ml不含酶的模拟胃液(SGF)中体外溶出所测量的, [0708] wherein, as measured by the USP Apparatus 1 (basket) at IOOrpm at 37 ° C for 900ml simulated gastric fluid without enzymes (SGF) measured in vitro dissolution,

[0709] 在2小时时从所述剂型释放的阿片样镇痛剂的量小于约25% ; [0709] 2 hours in an amount of opioid analgesic from the dosage form releases less than about 25%;

[0710] 在4小时时从所述剂型释放的阿片样镇痛剂的量为约10%至约30% ; Amount [0710] of opioid analgesic released at 4 hours from the dosage form is from about 10% to about 30%;

[0711] 在8小时时从所述剂型释放的阿片样镇痛剂的量为约20%至约60% ; Amount [0711] of opioid analgesic released at 8 hours from the dosage form is from about 20% to about 60%;

[0712] 在12小时时从所述剂型释放的阿片样镇痛剂的量为约40%至约90% ;和 [0712] The amount of opioid analgesic released at 12 hours from the dosage form is from about 40% to about 90%; and

[0713] 在18小时时从所述剂型释放的阿片样镇痛剂的量大于约70%。 [0713] amount of opioid analgesic released at 18 hours from the dosage form in about 70%.

[0714] 134. -种制备固体控制释放剂型的方法,其包括: [0714] 134. - The method of preparing a solid kind of controlled release dosage form, comprising:

[0715] 将治疗有效量的氢可酮或其可药用盐与控制释放赋形剂相组合; [0715] A therapeutically effective amount of hydrocodone or a pharmaceutically acceptable salt thereof in combination with the controlled release excipient;

[0716] 其中,如通过在USP装置1(篮)中以IOOrpm在37°C下于900ml不含酶的模拟胃液(SGF)中体外溶出所测量的,从所述剂型释放的氢可酮或其盐的量在8至24小时的任意两个时间点与经过时间在20%内成比例;并且 [0716] wherein, as measured by USP Apparatus 1 (basket) to IOOrpm at 37 ° C for 900ml simulated gastric fluid without enzymes (SGF) as measured in vitro dissolution, release from the dosage form in or hydrocodone a salt thereof in an amount of 8-24 hours in any two time points and the elapsed time is proportional to 20%; and

[0717] 所述剂型可被压扁而不破碎,其中被压扁后所述剂型的厚度相当于被压扁前所述剂型厚度的不超过约20% ;并且 [0717] The dosage form can be flattened without breaking, wherein a thickness of the dosage form after the flattening which corresponds to no more than about 20% of the thickness before flattening the dosage form; and

[0718] 如通过在USP装置1(篮)中以IOOrpm在37°C下于900ml不含酶的模拟胃液(SGF) 中体外溶出所测量的,在〇. 5小时时从被压扁剂型释放的氢可酮或其盐的量与未被压扁剂型相比偏差不超过约20%点。 [0718] The IOOrpm by 900ml simulated gastric fluid without enzymes (SGF) as dissolution in vitro at 37 ° C for measured in a USP Apparatus 1 (basket), and when the square. 5 hours released from the dosage form is crushed the hydrocodone or salt thereof and the amount of dosage form as compared to non-flattening deviation of less than about 20% points.

[0719] 135. -种制备固体控制释放剂型的方法,其包括: [0719] 135. - The method of preparing a solid kind of controlled release dosage form, comprising:

[0720] 将治疗有效量的氢可酮或其可药用盐与控制释放赋形剂相组合; [0720] A therapeutically effective amount of hydrocodone or a pharmaceutically acceptable salt thereof in combination with the controlled release excipient;

[0721] 其中,如通过在USP装置1(篮)中以IOOrpm在37°C下于900ml不含酶的模拟胃液(SGF)中体外溶出所测量的, [0721] wherein, as measured by the USP Apparatus 1 (basket) at IOOrpm at 37 ° C for 900ml simulated gastric fluid without enzymes (SGF) measured in vitro dissolution,

[0722] 在2小时时从所述剂型释放的氢可酮或其盐的量小于约25% ; [0722] at 2 hours is released from the dosage form of hydrocodone or salt thereof is less than about 25%;

[0723] 在4小时时从所述剂型释放的氢可酮或其盐的量为约10%至约30% ; [0723] at 4 hours released from the dosage form of hydrocodone or salt thereof from about 10% to about 30%;

[0724] 在8小时时从所述剂型释放的氢可酮或其盐的量为约20%至约60% ; The amount of [0724] is released at 8 hours from the dosage form of hydrocodone or a salt thereof is from about 20% to about 60%;

[0725] 在12小时时从所述剂型释放的氢可酮或其盐的量为约40%至约90% ;并且 The amount of [0725] at 12 hours released from the dosage form of hydrocodone or salt thereof from about 40% to about 90%; and

[0726] 在18小时时从所述剂型释放的氢可酮或其盐的量大于约70% ; [0726] at 18 hours released from the dosage form of hydrocodone or a salt thereof is greater than about 70%;

[0727] 并且 [0727] and

[0728] 所述剂型可被压扁而不破碎,其中被压扁后所述剂型的厚度相当于被压扁前所述剂型厚度的不超过约20% ;并且 [0728] The dosage form can be flattened without breaking, wherein a thickness of the dosage form after the flattening which corresponds to no more than about 20% of the thickness before flattening the dosage form; and

[0729] 如通过在USP装置1(篮)中以IOOrpm在37°C下于900ml不含酶的模拟胃液(SGF) 中体外溶出所测量的,在〇. 5小时时从被压扁剂型释放的氢可酮或其盐的量与未被压扁剂型相比偏差不超过约20%点。 [0729] The IOOrpm by 900ml simulated gastric fluid without enzymes (SGF) as dissolution in vitro at 37 ° C for measured in a USP Apparatus 1 (basket), and when the square. 5 hours released from the dosage form is crushed the hydrocodone or salt thereof and the amount of dosage form as compared to non-flattening deviation of less than about 20% points.

[0730] 136. -种制备固体控制释放剂型的方法,其包括: [0730] 136. - The method of preparing a solid kind of controlled release dosage form, comprising:

[0731] 将治疗有效量的氢可酮或其可药用盐分散到控制释放赋形剂中;其中所述剂型的内部60 %含有至少80 %的所述氢可酮或其盐; [0731] A therapeutically effective amount of hydrocodone or a pharmaceutically acceptable salt thereof dispersed in a controlled release excipient; wherein the interior of the dosage form comprises at least 80% to 60% of the hydrocodone or salt thereof;

[0732] 其中,如通过在USP装置1(篮)中以IOOrpm在37°C下于900ml不含酶的模拟胃液(SGF)中体外溶出所测量的,从所述剂型释放的氢可酮或其盐的量在8至24小时与经过时间在20%内成比例。 [0732] wherein, as measured by USP Apparatus 1 (basket) to IOOrpm at 37 ° C for 900ml simulated gastric fluid without enzymes (SGF) as measured in vitro dissolution, release from the dosage form in or hydrocodone a salt thereof in an amount of from 8 to 24 hours elapsed time and within 20% in proportion.

Claims (44)

1. 一种固体控制释放剂型,其包含: 核心,其包含分散在第一基质材料中的第一部分阿片样镇痛剂;和壳,其包覆所述核心并且包含分散在第二基质材料中的第二部分所述阿片样镇痛剂; 其中所述阿片样镇痛剂选自氢可酮、其可药用盐、其水合物、其溶剂合物、及其混合物; 其中,如通过在USP装置1(篮)中以IOOrpm在37°C下于900ml不含酶的模拟胃液(SGF)中体外溶出所测量的,从所述剂型释放的阿片样镇痛剂的量在8至24小时与经过时间在20%内成比例。 A solid controlled release dosage form comprising: a core, a first portion comprising an opioid analgesic dispersed in a first matrix material; and a shell that covers the core and comprising dispersed in a second matrix material said second portion of opioid analgesic; wherein the opioid analgesic is selected from hydrocodone, pharmaceutically acceptable salts, hydrates, solvates, and mixtures thereof; wherein, e.g., by the USP apparatus 1 (basket) to IOOrpm at 37 ° C for 900ml simulated gastric fluid without enzymes (SGF) measured in vitro dissolution, the amount of opioid analgesic released from the dosage form at 8-24 hours proportional to elapsed time within 20%.
2. 权利要求1的固体控制释放剂型,其中所述核心是压制片剂。 2. The solid controlled release dosage form as claimed in claim, wherein said core is a compressed tablet.
3. 权利要求1或2的固体控制释放剂型,其中所述壳是压制包衣。 The solid 1 or claim 2 controlled release dosage form, wherein the housing is a compression coating.
4. 权利要求1至3中任一项的固体控制释放剂型,其中所述第一基质材料包含聚环氧乙烧。 The solid according to any one of claims 1 to 3, 4. The controlled release dosage form, wherein the first matrix material comprises polyethylene oxide burn.
5. 权利要求1至4中任一项的固体控制释放剂型,其中所述第二基质材料包含聚环氧乙烧。 1 to 4 of any one solid controlled release dosage form, wherein the second matrix material comprises polyethylene oxide burn claim.
6. 权利要求1至3中任一项的固体控制释放剂型,其中所述第一基质材料和所述第二基质材料均包含聚环氧乙烷,其中优选地所述第二基质材料中的所述聚环氧乙烷具有比所述第一基质材料中的所述聚环氧乙烷更高的黏度。 The solid according to any one of claims 1 to 3, 6. The controlled release dosage form, wherein the first matrix material and the second matrix material contains polyethylene oxide, preferably wherein the second matrix material the polyethylene oxide having a higher viscosity than the polyethylene oxide of the first material of the matrix.
7. 权利要求4的固体控制释放剂型,其中所述第一基质材料包含平均分子量为约300, 000至约10, 000, 000、优选约500, 000至约1,000, 000的聚环氧乙烷。 4 solid controlled release dosage form of claim 1, wherein the first matrix material comprising an average molecular weight of about 300, about 000 to 10, 000, 000, preferably about 500, 000 to about 1,000, 000 polyepoxy ethane.
8. 权利要求5的固体控制释放剂型,其中所述第二基质材料包含平均分子量为约1,000, 000至约10, 000, 000、优选约6, 000, 000至约8, 000, 000的聚环氧乙烷。 The solid of claim 5 controlled release dosage form, wherein the second matrix material comprises an average molecular weight of about 000, about 000 to 10, 000, 000, preferably from about 6, 000, 000 to about 8, 000, 000 polyethylene oxide.
9. 权利要求6的固体控制释放剂型,其中所述第二基质材料中的所述聚环氧乙烷的平均分子量为约4, 000, 000至约10, 000, 000并且所述第一基质材料中的所述聚环氧乙烷的平均分子量为约300, 000至约3, 000, 000,或者其中所述第二基质材料中的所述聚环氧乙烷的平均分子量为约6, 000, 000至约8, 000, 000并且所述第一基质材料中的所述聚环氧乙烷的平均分子量为约500, 000至约1,000, 000。 The solid 6 000, about 000 to 10, 000, 000 and the first matrix controlled release dosage form of claim 9, wherein the second matrix material is polyethylene oxide of average molecular weight of about 4, material of said polyethylene oxide average molecular weight of about 300, about 000 to 3, 000, 000, or wherein the second matrix material is polyethylene oxide of average molecular weight of about 6, 000, 000 to about 8, 000, 000 and the first matrix material is polyethylene oxide of average molecular weight of about 500, 000 to about 1,000, 000.
10. 权利要求1至9中任一项的固体控制释放剂型,其中所述核心与所述壳的重量比为约1 : 0. 5至约1 : 5,优选为约1 : 0. 6至约1 : 1.5,更优选为约1 : 0. 8至约1 : 1.2。 10. The solid of claims 1 to 9 in a controlled release dosage form of any one, wherein the weight ratio of core to the shell is from about 1: 0.5 to about 1: 5, preferably from about 1: 0.6 to from about 1: 1.5, more preferably from about 1: 0.8 to about 1: 1.2.
11. 权利要求4的固体控制释放剂型,其中在所述第一基质材料中所述第一部分阿片样镇痛剂与聚环氧乙烷的重量比为约1 : 0.5至约1 : 100,优选为约I : 1至约1 : 10, 更优选为约I : 1. 5至约1 : 4。 4 11. The solid controlled release dosage form as claimed in claim, wherein said first weight matrix material in the first portion of the opioid analgesic to polyethylene oxide ratio of about 1: 0.5 to about 1: 100, preferably about the I: 1 to about 1: 10, more preferably from about I: 1. 5 to about 1: 4.
12. 权利要求5的固体控制释放剂型,其中在所述第二基质材料中所述第二部分阿片样镇痛剂与聚环氧乙烷的重量比为约1 : 2至约1 : 200,优选为约1 : 5至约1 : 50,更优选为约1 : 12至约1 : 25。 5 12. The solid controlled release dosage form as claimed in claim, wherein the second portion of the weight of opioid analgesic polyethylene oxide in the ratio of about 1 second matrix material: 2 to about 1: 200, preferably from about 1: 5 to about 1: 50, more preferably from about 1: 12 to about 1:25.
13. 权利要求1至12中任一项的固体控制释放剂型,其中所述核心中阿片样镇痛剂与所述壳中阿片样镇痛剂的比率为约I : 1至约10 : 1,优选为约2 : 1至约8 : 1,更优选为约2 : 1至约5 : 1。 13. The solid 1 to 12 of a controlled release dosage form as claimed in claim, wherein the ratio of the opioid analgesic in the core and the shell opioid analgesic is about the I: 1 to about 10: 1, preferably from about 2: 1 to about 8: 1, more preferably from about 2: 1 to about 5: 1.
14. 权利要求1至13中任一项的固体控制释放剂型,其中所述阿片样镇痛剂为重酒石酸氢可酮。 14. The solid 1 to 13 of a controlled release dosage form as claimed in claim, wherein said opioid analgesic is hydrocodone bitartrate.
15. 权利要求14的固体控制释放剂型,其中重酒石酸氢可酮在所述剂型中的总量为约0• 5mg至约1250mg,或约2mg至约200mg,或约16mg至约120mg。 14 15. The solid controlled release dosage form as claimed in claim, wherein the hydrocodone bitartrate in the dosage form in total amount of about 0 • 5mg to about 1250 mg, or from about 2mg to about 200mg, or about 16mg to about 120mg.
16. 权利要求1至15中任一项的固体控制释放剂型,其中释放的阿片样镇痛剂的量在8至24小时与经过时间在10 %内,优选在5 %内成比例。 Opioid analgesic amount of 1 to 15 solid controlled release dosage form of any one, which is released in claim 16. 8-24 hours elapsed time within 10%, preferably to within 5% of the proportion.
17. 权利要求1至15中任一项的固体控制释放剂型,其中释放的阿片样镇痛剂的量在8至18小时与经过时间在20%内,优选在10%内或在5%内成比例。 17. The solid 1 to 15 of a controlled release dosage form as claimed in claim, the amount of opioid analgesic released at 8 to 18 hours elapsed time and within 20%, preferably within 10% or within 5% proportional.
18. 权利要求1至15中任一项的固体控制释放剂型,其中释放的阿片样镇痛剂的量在8至12小时与经过时间在20%内,优选在10%内或在5%内成比例。 18. The solid 1 to 15 of a controlled release dosage form as claimed in claim, the amount of opioid analgesic released at 8 to 12 hours elapsed time and within 20%, preferably within 10% or within 5% proportional.
19. 权利要求1至15中任一项的固体控制释放剂型,其中释放的阿片样镇痛剂的量在12至24小时与经过时间在20 %内,优选在10 %内或在5 %内成比例。 19. The solid 1 to 15 of a controlled release dosage form as claimed in claim, the amount of opioid analgesic released at 12 to 24 hours elapsed time and within 20%, preferably within 10% or within 5% proportional.
20. 权利要求1至15中任一项的固体控制释放剂型,其中释放的阿片样镇痛剂的量在12至18小时与经过时间在20%内,优选在10%内或在5%内成比例。 20. The solid 1 to 15 of a controlled release dosage form as claimed in claim, the amount of opioid analgesic released at 12 to 18 hours elapsed time and within 20%, preferably within 10% or within 5% proportional.
21. 权利要求1至20中任一项的固体控制释放剂型,其中在2小时时释放的阿片样镇痛剂的量小于约25%,和/或其中在4小时时释放的阿片样镇痛剂的量为约10%至约30%,和/或其中在8小时时释放的阿片样镇痛剂的量为约20%至约60%,和/或其中在12小时时释放的阿片样镇痛剂的量为约40%至约90%,和/或其中在18小时时释放的阿片样镇痛剂的量大于约70%。 21. The solid of claims 1 to 20 in any one controlled release dosage form, the amount of opioid analgesic released at 2 hours is less than about 25% and / or released at 4 hours opioid analgesic dose is from about 10% to about 30%, and or the amount of opioid analgesic released at 8 hours / wherein from about 20% to about 60%, and / or wherein the opioid released at 12 hours analgesic amount is from about 40% to about 90%, and / or wherein the amount of opioid analgesic released at 18 hours about 70%.
22. 权利要求1至21中任一项的固体控制释放剂型,其中在2小时时释放的阿片样镇痛剂的量小于约20%,和/或其中在4小时时释放的阿片样镇痛剂的量为约10%至约20%,和/或其中在8小时时释放的阿片样镇痛剂的量为约20%至约40%,和/或其中在12小时时释放的阿片样镇痛剂的量为约40%至约65%,和/或其中在18小时时释放的阿片样镇痛剂的量大于约80%。 22. The solid of claims 1 to 21 in controlled release dosage form according to any one of the amount of opioid analgesic released at 2 hours is less than about 20%, and / or released at 4 hours opioid analgesic dose is from about 10% to about 20%, and / or wherein the amount of opioid analgesic released at 8 hours about 20% to about 40%, and / or wherein the opioid released at 12 hours analgesic amount is from about 40% to about 65%, and / or wherein the amount of opioid analgesic released at 18 hours about 80%.
23. 权利要求1至22中任一项的固体控制释放剂型,其中在2小时时释放的阿片样镇痛剂的量小于约15%,和/或其中在4小时时释放的阿片样镇痛剂的量为约20%至约30%,和/或其中在8小时时释放的阿片样镇痛剂的量为约45%至约60%,和/或其中在12小时时释放的阿片样镇痛剂的量为约70%至约90%,和/或其中在18小时时释放的阿片样镇痛剂的量大于约90%。 1 to 22. The solid controlled release dosage form according to any one of the amount of opioid analgesic released at 2 hours is less than about 15%, and / or released at 4 hours opioid analgesic claimed in claim 23 dose is from about 20% to about 30%, and / or wherein the amount of opioid analgesic released at 8 hours from about 45% to about 60%, and / or wherein the opioid released at 12 hours analgesic amount of from about 70% to about 90%, and / or wherein the amount of opioid analgesic released at 18 hours about 90%.
24. 权利要求6的固体控制释放剂型,其中可通过在至少所述聚环氧乙烷之软化点的温度下熟化所述剂型至少1分钟,至少5分钟,或至少15分钟得到所述固体控制释放剂型。 6 24. The solid controlled release dosage form as claimed in claim, wherein the dosage form by aging at a temperature of at least the polyethylene oxide of the softening point of at least 1 minute, at least 5 minutes, or at least 15 minutes to obtain a solid control release dosage forms.
25. 权利要求6的固体控制释放剂型,其中可通过在至少所述聚环氧乙烷之软化点的温度下熟化所述剂型约1分钟至约48小时,或约5分钟至约24小时,或约15分钟至约1 小时得到所述固体控制释放剂型。 6 25. The solid controlled release dosage form as claimed in claim, wherein the temperature of at least by the polyethylene oxide of the softening point of the curing dosage from about 1 minute to about 48 hours, or from about 5 minutes to about 24 hours, or from about 15 minutes to about 1 hour to obtain a solid controlled release dosage form.
26. 权利要求24或25的固体控制释放剂型,其中可通过在至少约60°C、至少约65°C、 至少约70°C、至少约75°C、或约72°C的温度下熟化所述剂型得到所述固体控制释放剂型。 24 26. The solid of claim 25 or controlled release dosage form, wherein the at least by about 60 ° C, at least about 65 ° C, at least about 70 ° C, curing temperature of at least about 75 ° C, or from about 72 ° C to the solid dosage form to obtain the controlled release dosage form.
27. 权利要求24或25的固体控制释放剂型,其中可通过在约60°C至约90°C、或约65°C 至约85°C、或约70°C至约80°C、或约75°C至约80°C、或约70°C至约75°C的温度下熟化所述剂型得到所述固体控制释放剂型。 24 27. The solid of claim 25 or controlled release dosage form, which can be obtained by about 60 ° C to about 90 ° C, or from about 65 ° C to about 85 ° C, or from about 70 ° C and about 80 ° C, or about 75 ° C to about 80 ° C, or from about 70 ° C and at a temperature of about 75 ° C to give the dosage form of the solid curing controlled release dosage form.
28. 权利要求1至27中任一项的固体控制释放剂型,其中所述核心和所述壳在视觉上不可区分,或者其中所述核心和所述壳具有彼此10%以内的CIE L * A * B *值。 28. The solid of claims 1 to 27 in controlled release dosage form of any one of, wherein the core and the shell is indistinguishable visually, or wherein said core and said housing having within 10% of each other CIE L * A * B * values.
29. 权利要求1至28中任一项的固体控制释放剂型,其中所述剂型可被压扁而不破碎, 其中被压扁后所述剂型的厚度相当于被压扁前所述剂型厚度的不超过约60%,优选地被压扁后所述剂型的厚度相当于被压扁前所述剂型厚度的不超过约50%,或不超过约40%,或不超过约30 %,或不超过约20 %。 The solid in any one of 1 to 28 29. The controlled release dosage form as claimed in claim, wherein said dosage form can be flattened without breaking, wherein a thickness of the dosage form after the flattening which corresponds to the thickness of the dosage form before flattening no more than about 60%, preferably after the flattening corresponds to the thickness of the dosage form before the dosage form flattening a thickness no more than about 50%, or no more than about 40%, or no more than about 30%, or more than about 20%.
30. 权利要求29的固体控制释放剂型,其中,如通过在USP装置1(篮)中以IOOrpm在37°C下于900ml不含酶的模拟胃液(SGF)中体外溶出所测量的,在0. 5小时时从被压扁剂型释放的阿片样镇痛剂的量与未被压扁剂型相比偏差不超过约20%点,或不超过约15% 点,或不超过约10%点。 29 30. The solid controlled release dosage form as claimed in claim, wherein, as in USP Apparatus 1 (basket) at IOOrpm at 37 ° C for 900ml simulated gastric fluid without enzymes (SGF) in-vitro dissolution as measured by, at 0 from the flattened opioid analgesic when the dosage form releases After 5 hours the dosage amount compared to the non flattening deviation of less than about 20% points or no more than about 15% points or no more than about 10% points.
31. 权利要求1至30中任一项的固体控制释放剂型,其在施用后提供约0. 55至约I. 0 的氢可酮的C24/Cmax比率,优选地所述C24/C max比率为约0. 55至约0. 85,或约0. 55至约0. 75, 或约0. 60至约0. 70。 31. The solid of claims 1 to 30 in any one of the controlled release dosage form to provide C24 / Cmax ratio of from about 0.55 to about 0. I. hydrogen oxycodone after administration, preferably the C24 / C max ratio from about 0.55 to about 0.85, or from about 0.55 to about 0.75, or from about 0.60 to about 0.70.
32. 权利要求1至31中任一项的固体控制释放剂型,其在施用后提供约4至约20小时的氢可酮的Tmax (h),优选地在施用所述剂型之后所述Tmax(h)为约6至约12小时,或约8 至约10小时,或约4至约10小时,或约8至约14小时,或约14至约20小时。 After solid. 1 to 31 according to claim 32. The controlled release dosage form, which provides a Tmax from about 4 to about 20 hours hydrocodone (h) after administration, the dosage form is preferably administered at the Tmax ( h) from about 6 to about 12 hours, or from about 8 to about 10 hours, or from about 4 to about 10 hours, or from about 8 to about 14 hours, or from about 14 to about 20 hours.
33. 权利要求31或32的固体控制释放剂型,其中所述施用为向健康对象或健康对象之群体的首次施用,或者其中所述施用为向健康对象或健康对象之群体的稳态施用。 31 or 33. The solid of claim 32 controlled release dosage form, wherein the administration is a first administration to a healthy subject or population of healthy subjects, or wherein the administration is steady state administration to a healthy subject population of healthy subjects or of.
34. 权利要求1至13中任一项的固体控制释放剂型,其含有约20mg氢可酮或其可药用盐。 1 to 13, any one of a solid controlled release dosage form containing from about 20mg hydrocodone or a pharmaceutically acceptable salt thereof as claimed in claim 34.
35. 权利要求1至13中任一项的固体控制释放剂型,其含有约120mg氢可酮或其可药用盐。 1 to 13, any one of a solid controlled release dosage form comprising about 120mg hydrocodone or a pharmaceutically acceptable salt thereof as claimed in claim 35.
36. 权利要求1至13中任一项的固体控制释放剂型,其在施用后每20mg包含在所述剂型中的氢可酮提供约250至400的平均AUC (ng * h/mL),和/或其在施用后每20mg包含在所述剂型中的氢可酮提供约10至约30的平均Cniax (ng/mL)。 1 to 13 to a solid controlled release dosage form as claimed in claim 36, in which the hydrogen contained 20mg per dosage form provides a mean AUC may be one of about 250 to 400 (ng * h / mL) after administration, and / or after administration each containing 20mg of hydrogen in the dosage form 10 may provide about one to about 30. the average Cniax (ng / mL).
37. 权利要求34的固体控制释放剂型,其在施用后提供约250至约400、约275至约350、约300至330或约280至约320的平均AUC (ng * h/mL),和/或其在施用后提供约10 至约30、约12至约25、约14至约18或约12至约17的平均C niax (ng/mL)。 The solid controlled release dosage form as claimed in claim 37. 34, which provides about 250 to about 400 after administration, from about 275 to about 350, an average AUC of about 300 to 330 or about 280 to about 320 (ng * h / mL), and / or provides from about 10 to about 30 after administration of the average C niax (ng / mL) from about 12 to about 25, from about 14 to about 18, or about 12 to about 17.
38. 权利要求35的固体控制释放剂型,其在施用后提供约1500至约2400、约1700至约2200、约1800至约2100或约1900至约2100的平均AUC (ng * h/mL),和/或其在施用后提供约60至约180、约100至约160、约110至约150或约100至约140的平均C niax (ng/ mL)。 35 38. The solid controlled release dosage form as claimed in claim, in which the administration provides from about 1500 to about 2400, from about 1700 to about 2200, from about 1800 to about 2100, or a mean AUC from about 1900 to about 2100 (ng * h / mL), and / or to provide about 60 to about 180 after administration, from about 100 to about 160, an average C niax about 110 to about 150, or about 100 to about 140 (ng / mL).
39. 权利要求1至13中任一项的固体控制释放剂型,其在施用后提供约10至约20、约12至约18、约13至约17或约14至约16的平均T_(h),和/或其在施用后提供约5至约10、约6至约9、约7或约8的平均T1/2 (h),和/或其在施用后提供约0. 01至约0. 2、约0. 1 至约0. 18、约0. 3至约0. 17或约0. 06至约0. 15的平均TlagQi),和/或其中所述平均C24/ (:_比率为约0. 2至约0. 8、约0. 3至约0. 7或约0. 4至约0. 6。 The solid 1 to 13 according to claim 39. The controlled release dosage form, after administration provides from about 10 to about 20, from about 12 to about 18, an average of from about 13 to about 17 T_, or from about 14 to about 16, (h ), and / or to provide from about 5 to about 10, from about 6 to about 9, or after administration of about 7 to about 8, an average T1 / 2 (h), and / or after administration to provide from about 0.01 to about 0.2, from about 0.1 to about 0.18, an average TlagQi about 0.3 to about 0.17, or about 0.06 to about 0.15 in), and / or wherein the mean C24 / (: _ ratio of about 0.2 to about 0.8, from about 0.3 to about 0.7, or about 0.4 to about 0.6.
40. 权利要求36至40中任一项的固体控制释放剂型,其中在禁食状态下进行施用。 The solid 36-40 of any one of claim 40. A controlled release dosage form, which is administered in the fasted state.
41. 权利要求1至13中任一项的固体控制释放剂型,其中在进食状态下施用后的平均AUC(ng * h/mL)比在禁食状态下施用后的AUC(ng * h/mL)高出不到20%、不到16%或不到12%,和/或其中在进食状态下施用后的平均Cmax(ng/mL)比在禁食状态下施用后的C max (ng/mL)高出不到80%、不到70 %或不到60%。 41. The solid of claims 1 to 13 in controlled release dosage form of any one of, wherein the mean AUC after administration in the fed state (ng * h / mL) than the AUC after administration in the fasted state (ng * h / mL ) higher than 20%, less than 16%, or less than 12% and / or wherein the mean Cmax (ng / mL) after administration in the fed state than the C max after administration in the fasted state (ng / mL) higher than 80%, less than 70%, or less than 60%.
42. 权利要求1至13中任一项的固体控制释放剂型,其中在进食状态下施用后的平均Tmax (h)为在禁食状态下施用后的Tmax (h)的25 %以内、20 %以内或15 %以内,和/或其中在进食状态下施用后的平均T1/2(h)为在禁食状态下施用后的T1/2(h)的8%以内、5%以内或2%以内,和/或其中在进食状态下施用后的平均T lag(h)比在禁食状态下施用后的T1/2高出不到150%、不到125 %或不到100%。 42. The solid of claims 1 to 13 in controlled release dosage form of any one of, wherein the mean Tmax after administration in the fed state (h) is within 25% Tmax (h) after administration in the fasted state, 20% within 15%, within or within and / or wherein the average T1 after administration in the fed state / 2 (h) for the T1 / 2 after administration in the fasted state (h), 8%, 5%, or less than 2% or less, and / or wherein the average T lag (h) after administration in the fed state is less than 150% higher than the T1 / 2 after administration in the fasted state, is less than 125%, or less than 100%.
43. 权利要求1至42中任一项的固体控制释放剂型,其用于在有此需要的对象中治疗疼痛的方法。 Solid. 1 to 42 according to claim 43. The controlled release dosage form, method of treating pain in a subject in need thereof used.
44. 一种制备固体控制释放剂型的方法,其包括: 制备核心,所述核心包含分散在第一基质材料中的第一部分阿片样镇痛剂;和用壳包覆所述核心,所述壳包含分散在第二基质材料中的第二部分所述阿片样镇痛剂; 其中所述阿片样镇痛剂选自氢可酮、其可药用盐、其水合物、其溶剂合物、及其混合物; 其中,如通过在USP装置1(篮)中以IOOrpm在37°C下于900ml不合酶的模拟胃液(SGF)中体外溶出所测量的,从所述剂型释放的阿片样镇痛剂的量在8至24小时与经过时间在20%内成比例。 44. A method of preparing a solid controlled release dosage form, comprising: preparing a core, said core comprising a first portion opioid analgesic dispersed in a first matrix material; and coating the core with a shell comprising a second portion of the opioid analgesic dispersed in a second matrix material; wherein the opioid analgesic is selected from hydrocodone, pharmaceutically acceptable salts, hydrates, solvates thereof, and mixtures thereof; wherein, as measured by USP apparatus 1 (basket) at IOOrpm to simulated gastric fluid at 37 ° C for not 900ml synthase (SGF) as measured in vitro dissolution, release from the dosage form an opioid analgesic in the in an amount of from 8 to 24 hours elapsed time and within 20% in proportion.
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