CN104817519A - 一类ca-4的衍生物、其制法及其医药用途 - Google Patents

一类ca-4的衍生物、其制法及其医药用途 Download PDF

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Publication number
CN104817519A
CN104817519A CN 201510235806 CN201510235806A CN104817519A CN 104817519 A CN104817519 A CN 104817519A CN 201510235806 CN201510235806 CN 201510235806 CN 201510235806 A CN201510235806 A CN 201510235806A CN 104817519 A CN104817519 A CN 104817519A
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acid
arh
2h
1h
ethyl acetate
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CN 201510235806
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English (en)
Chinese (zh)
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CN104817519B (zh )
Inventor
徐云根
刘坤
宋晓翰
陈泓竹
张宏波
张灵芝
朱启华
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中国药科大学
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/38Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
CN 201510235806 2015-05-11 2015-05-11 一类ca-4的衍生物、其制法及其医药用途 CN104817519B (zh)

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CN 201510235806 CN104817519B (zh) 2015-05-11 2015-05-11 一类ca-4的衍生物、其制法及其医药用途

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CN 201510235806 CN104817519B (zh) 2015-05-11 2015-05-11 一类ca-4的衍生物、其制法及其医药用途

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CN104817519A true true CN104817519A (zh) 2015-08-05
CN104817519B CN104817519B (zh) 2016-11-16

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Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006138427A2 (en) * 2005-06-14 2006-12-28 Baylor University Combretastatin analogs with tubulin binding activity
WO2009118474A1 (fr) * 2008-02-28 2009-10-01 Sanofi-Aventis Procede de preparation de combretastatine
EP2338877A1 (en) * 2009-12-15 2011-06-29 The Provost, Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth near Dublin Combretastatin Derivatives and Uses Therefor
CN102219811A (zh) * 2011-04-14 2011-10-19 中国药科大学 Ca-4衍生物、其制法及其医药用途
CN102249987A (zh) * 2011-05-06 2011-11-23 兰州大学 一种考布他汀类化合物及其制备方法和用途
CN102863472A (zh) * 2012-10-15 2013-01-09 中国海洋大学 考布他汀a-4类似物及其制备方法和在制备抗肿瘤药物中的应用
CN102906076A (zh) * 2009-12-03 2013-01-30 赛诺菲 考布他汀衍生物制备方法
WO2013026942A1 (en) * 2011-08-25 2013-02-28 The Provost, Fellows, Foundation Scholars, And The Other Members Of Board, Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth, Near Dublin Tubulin binding agents
CN102985410A (zh) * 2010-05-05 2013-03-20 拜罗伊特大学 在癌症的治疗中使用的考布他汀类似物
CN103421057A (zh) * 2013-08-14 2013-12-04 合肥医工医药有限公司 康普瑞汀氨基糖缀合物、其制法及其医药用途
CN103524349A (zh) * 2013-10-19 2014-01-22 山东大学 Ca-4碳酸酯类衍生物、其制备方法、药物组合物与医药用途
WO2014181085A1 (en) * 2013-05-09 2014-11-13 Kenneth Dawson Bagshawe Tumour therapy

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006138427A2 (en) * 2005-06-14 2006-12-28 Baylor University Combretastatin analogs with tubulin binding activity
WO2009118474A1 (fr) * 2008-02-28 2009-10-01 Sanofi-Aventis Procede de preparation de combretastatine
CN102906076A (zh) * 2009-12-03 2013-01-30 赛诺菲 考布他汀衍生物制备方法
EP2338877A1 (en) * 2009-12-15 2011-06-29 The Provost, Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth near Dublin Combretastatin Derivatives and Uses Therefor
CN102985410A (zh) * 2010-05-05 2013-03-20 拜罗伊特大学 在癌症的治疗中使用的考布他汀类似物
CN102219811A (zh) * 2011-04-14 2011-10-19 中国药科大学 Ca-4衍生物、其制法及其医药用途
CN102249987A (zh) * 2011-05-06 2011-11-23 兰州大学 一种考布他汀类化合物及其制备方法和用途
WO2013026942A1 (en) * 2011-08-25 2013-02-28 The Provost, Fellows, Foundation Scholars, And The Other Members Of Board, Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth, Near Dublin Tubulin binding agents
CN102863472A (zh) * 2012-10-15 2013-01-09 中国海洋大学 考布他汀a-4类似物及其制备方法和在制备抗肿瘤药物中的应用
WO2014181085A1 (en) * 2013-05-09 2014-11-13 Kenneth Dawson Bagshawe Tumour therapy
CN103421057A (zh) * 2013-08-14 2013-12-04 合肥医工医药有限公司 康普瑞汀氨基糖缀合物、其制法及其医药用途
CN103524349A (zh) * 2013-10-19 2014-01-22 山东大学 Ca-4碳酸酯类衍生物、其制备方法、药物组合物与医药用途

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
何书英,等: "考布他汀A-4衍生物CPU-XT-006对人脐静脉内皮细胞增殖、凋亡及VEGF、bFGF表达的影响", 《中国药科大学学报》 *

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